Title:
STEM CELL-DERIVED EXOSOMES CONTAINING PAIN REGULATORS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/206459
Kind Code:
A1
Abstract:
The present invention relates to an exosome-based pharmaceutical composition for alleviating and treating pain. Exosomes according to the present invention contain various cytokines, genes, bioactive factors, proteins, and the like, related to regeneration of nerve cells and alleviation of pain, that are secreted in the process of cell proliferation and cell behavior, and thus may cure the underlying causes of pain.
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Inventors:
CHO YONG WOO (KR)
CHOI JI SUK (KR)
KIM WOO SUNG (KR)
WOO CHANG HEE (KR)
CHOI JI SUK (KR)
KIM WOO SUNG (KR)
WOO CHANG HEE (KR)
Application Number:
PCT/KR2021/004384
Publication Date:
October 14, 2021
Filing Date:
April 07, 2021
Export Citation:
Assignee:
EXOSTEMTECH CO LTD (KR)
International Classes:
A61K35/28; A61K9/00; A61P25/04; A61P29/00
Foreign References:
| US20180036348A1 | 2018-02-08 | |||
| KR20180016720A | 2018-02-19 | |||
| KR20190066885A | 2019-06-14 | |||
| KR102193175B1 | 2020-12-18 | |||
| KR20200042397A | 2020-04-23 | |||
| EP2010069426W | 2010-12-10 |
Other References:
SHIUE SHENG-JIE, RAU RUEY-HORNG, SHIUE HAN-SHIANG, HUNG YI-WEI, LI ZHI-XIANG, YANG KUENDER D., CHENG JEN-KUN: "Mesenchymal stem cell exosomes as a cell-free therapy for nerve injury–induced pain in rats", PAIN, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, vol. 160, no. 1, 1 January 2019 (2019-01-01), NL , pages 210 - 223, XP055856276, ISSN: 0304-3959, DOI: 10.1097/j.pain.0000000000001395
CHEN JING, REN SEN, DUSCHER DOMINIK, KANG YU, LIU YUTIAN, WANG CHENG, YUAN MENG, GUO GUOJUN, XIONG HEWEI, ZHAN PENG, WANG YANG, MA: "Exosomes from human adipose‐derived stem cells promote sciatic nerve regeneration via optimizing Schwann cell function", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., US, vol. 234, no. 12, 1 December 2019 (2019-12-01), US , pages 23097 - 23110, XP055856280, ISSN: 0021-9541, DOI: 10.1002/jcp.28873
CHEN JING, REN SEN, DUSCHER DOMINIK, KANG YU, LIU YUTIAN, WANG CHENG, YUAN MENG, GUO GUOJUN, XIONG HEWEI, ZHAN PENG, WANG YANG, MA: "Exosomes from human adipose‐derived stem cells promote sciatic nerve regeneration via optimizing Schwann cell function", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., US, vol. 234, no. 12, 1 December 2019 (2019-12-01), US , pages 23097 - 23110, XP055856280, ISSN: 0021-9541, DOI: 10.1002/jcp.28873
Attorney, Agent or Firm:
PHIL & ONZI INT'L PATENT & LAW FIRM (KR)
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