Title:
STEROID COMPOUND, AND USE THEREOF AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/143640
Kind Code:
A1
Abstract:
The present invention relates to a steroid compound, and a use thereof and a preparation method therefor. It is expected that such compound can effectively treat mental and neurological diseases, and has good active efficacy, pharmacokinetic (PK) performance, oral bioavailability, stability, safety, clearance rate, and/or metabolic performance and the like.
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| JPS53133637 | PHARMACEUTICAL COMPOSITION |
Inventors:
KE XIAO (CN)
WANG YIQIAN (CN)
CHEN PEI (CN)
WANG YIQIAN (CN)
CHEN PEI (CN)
Application Number:
PCT/CN2020/070755
Publication Date:
July 16, 2020
Filing Date:
January 07, 2020
Export Citation:
Assignee:
CHENGDU KANGHONG PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/57; C07J63/00; A61P25/00; C07J61/00
Domestic Patent References:
| WO2019126761A1 | 2019-06-27 | |||
| WO2019154257A1 | 2019-08-15 | |||
| WO2019154247A1 | 2019-08-15 |
Foreign References:
| CN1190404A | 1998-08-12 | |||
| CN105339381A | 2016-02-17 | |||
| US4056633A | 1977-11-01 | |||
| CN103958540A | 2014-07-30 | |||
| CN1053928A | 1991-08-21 | |||
| CN105339381A | 2016-02-17 |
Other References:
WANG JUNCHENG ET AL., CHINA HEALTH SERVICE MANAGEMENT, vol. 2009, no. 5, pages 348 - 350
LAN, NC ET AL., NEUROCHEM. RES., vol. 16, 1991, pages 347 - 356
MAJEWSKA, M. D. ET AL., SCIENCE, vol. 232, 1986, pages 1004 - 1007
HARRISON, N. L. ET AL., J. PHARMACOL. EXP. THER., vol. 241, 1987, pages 346 - 353
BACKSTROM, T. ET AL., ACTA OBSTET. GYNECOL. SCAND., vol. 130, 1985, pages 19 - 24
PFAFF, D.WMCEWEN, B. S., SCIENCE, vol. 219, 1983, pages 808 - 814
GYERMEK ET AL., J MED CHEM., vol. 11, 1968, pages 117
LAMBERT, J. ET AL., TRENDS PHARMACOL. SCI., vol. 8, 1987, pages 224 - 227
DALTON, K.: "Premenstrual Syndrome and Progesterone Therapy", 1984, CHICAGO YEARBOOK
LAIDLAW, J., LANCET, 1956, pages 1235 - 1237
ROSCISZEWSKA ET AL., J. NEUROL. NEUROSURG. PSYCH., vol. 49, 1986, pages 47 - 51
BACKSTROM, T. ET AL., J. PSYCHOSOM. OBSTET. GYNAECOL., vol. 2, 1983, pages 8 - 20
AIRD, RB.GORDAN, G, J. AMER. MED. SOC., vol. 145, 1951, pages 715 - 719
"Activation of GABA(A) Receptors: Views from Outside the Synaptic Cleft", NEURON, vol. 56, 2007, pages 763 - 770
"Endogenous neurosteroids regulate GABA(A) receptors through two discrete transmembrane sites", NATURE, vol. 444, 23 November 2006 (2006-11-23), pages 486 - 489
BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
See also references of EP 3909967A4
LAN, NC ET AL., NEUROCHEM. RES., vol. 16, 1991, pages 347 - 356
MAJEWSKA, M. D. ET AL., SCIENCE, vol. 232, 1986, pages 1004 - 1007
HARRISON, N. L. ET AL., J. PHARMACOL. EXP. THER., vol. 241, 1987, pages 346 - 353
BACKSTROM, T. ET AL., ACTA OBSTET. GYNECOL. SCAND., vol. 130, 1985, pages 19 - 24
PFAFF, D.WMCEWEN, B. S., SCIENCE, vol. 219, 1983, pages 808 - 814
GYERMEK ET AL., J MED CHEM., vol. 11, 1968, pages 117
LAMBERT, J. ET AL., TRENDS PHARMACOL. SCI., vol. 8, 1987, pages 224 - 227
DALTON, K.: "Premenstrual Syndrome and Progesterone Therapy", 1984, CHICAGO YEARBOOK
LAIDLAW, J., LANCET, 1956, pages 1235 - 1237
ROSCISZEWSKA ET AL., J. NEUROL. NEUROSURG. PSYCH., vol. 49, 1986, pages 47 - 51
BACKSTROM, T. ET AL., J. PSYCHOSOM. OBSTET. GYNAECOL., vol. 2, 1983, pages 8 - 20
AIRD, RB.GORDAN, G, J. AMER. MED. SOC., vol. 145, 1951, pages 715 - 719
"Activation of GABA(A) Receptors: Views from Outside the Synaptic Cleft", NEURON, vol. 56, 2007, pages 763 - 770
"Endogenous neurosteroids regulate GABA(A) receptors through two discrete transmembrane sites", NATURE, vol. 444, 23 November 2006 (2006-11-23), pages 486 - 489
BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
See also references of EP 3909967A4
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