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Title:
STEROIDS AND ANTIBODY-CONJUGATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/136487
Kind Code:
A3
Abstract:
Described herein protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.

Inventors:
HAN AMY (US)
Application Number:
PCT/US2019/012786
Publication Date:
September 12, 2019
Filing Date:
January 08, 2019
Export Citation:
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Assignee:
REGENERON PHARMA (US)
International Classes:
A61K47/68; C07J71/00
Domestic Patent References:
WO2018089373A22018-05-17
WO2018213077A12018-11-22
WO1994015947A11994-07-21
WO2017132103A22017-08-03
WO2017210471A12017-12-07
WO2009002993A12008-12-31
WO1997041144A11997-11-06
WO2010132743A12010-11-18
WO1994022898A11994-10-13
Foreign References:
EP2407476A12012-01-18
GB1292269A1972-10-11
CN101397328A2009-04-01
DE1165595B1964-03-19
GB889766A1962-02-21
US20160279054A12016-09-29
Other References:
JEFFREY C. KERN ET AL: "Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, no. 4, 25 January 2016 (2016-01-25), pages 1430 - 1445, XP055577573, ISSN: 0002-7863, DOI: 10.1021/jacs.5b12547
JEFFREY C. KERN ET AL: "Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs", BIOCONJUGATE CHEMISTRY, vol. 27, no. 9, 28 July 2016 (2016-07-28), pages 2081 - 2088, XP055557206, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.6b00337
PIA SVENDSEN ET AL: "Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes", MOLECULAR THERAPY - METHODS & CLINICAL DEVELOP, vol. 4, March 2017 (2017-03-01), pages 50 - 61, XP055578466, ISSN: 2329-0501, DOI: 10.1016/j.omtm.2016.11.004
JONAS H GRAVERSEN ET AL: "Targeting the Hemoglobin Scavenger receptor CD163 in Macrophages Highly Increases the Anti-inflammatory Potency of Dexamethasone", MOLECULAR THERAPY, vol. 20, no. 8, August 2012 (2012-08-01), pages 1550 - 1558, XP055567958, ISSN: 1525-0016, DOI: 10.1038/mt.2012.103
AHERNE G W ET AL: "A sensitive radioimmunoassay for budesonide in plasma", JOURNAL OF STEROID BIOCHEMISTRY, vol. 17, no. 5, November 1982 (1982-11-01), pages 559 - 565, XP023414072, ISSN: 0022-4731, [retrieved on 19821101], DOI: 10.1016/0022-4731(82)90016-4
KRONKVIST K ET AL: "DETERMINATION OF DRUGS IN BIOSAMPLES AT PICOMOLAR CONCENTRATIONS USING COMPETITIVE ELISA WITH ELECTROCHEMICAL DETECTION: APPLICATION TO STEROIDS", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 11, no. 6, 1993, pages 459 - 463, XP000972921, ISSN: 0731-7085, DOI: 10.1016/0731-7085(93)80158-W
Attorney, Agent or Firm:
RICE, Janice et al. (US)
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