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Title:
STRUCTURAL COLOR MICROFIBER OF HETEROGENEOUS STRUCTURE, PREPARATION METHOD THEREFOR, AND CARDIOMYOCYTE DETECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2022/105869
Kind Code:
A1
Abstract:
A structural color microfiber of a heterogeneous structure, a preparation method therefor, and a cardiomyocyte detection method, the preparation method being: using capillaries to construct a microfluidic chip to be used as a preparation platform for the structural color micro-fiber of a heterogeneous structure, configuring prepolymer liquids as fiber components, and dividing the prepolymer liquids into two types, one type of prepolymer liquid being a biocompatible hydrogel solution (3), and the other type of prepolymer liquid being at least one concentration of a silicon dioxide, non-densely packed colloidal crystal pre-gel (2), a photoinitiator being added into each prepolymer liquid; and the two types of prepolymers being alternately injected in sequence by the microfluidic chip into a collection tube (4), and continuously irradiating the collection tube (4) part by means of ultraviolet light (5) to obtain the structural color microfiber of a heterogeneous structure. Preparation is controllable, costs are cheap, and visualized quantitative sensing of myocyte physiology is achieved.

Inventors:
ZHAO YUANJIN (CN)
CHEN ZHUOYUE (CN)
WANG YUETONG (CN)
CHI JUNJIE (CN)
ZHANG DAGAN (CN)
SHANG LUORAN (CN)
Application Number:
PCT/CN2021/131723
Publication Date:
May 27, 2022
Filing Date:
November 19, 2021
Export Citation:
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Assignee:
NANJING DRUM TOWER HOSPITAL (CN)
International Classes:
G01N21/78; D01F1/10; D01F6/44; G01B11/16
Foreign References:
CN112485247A2021-03-12
CN107907484A2018-04-13
CN107941678A2018-04-20
CN110542683A2019-12-06
CN110407163A2019-11-05
US20200024560A12020-01-23
Other References:
CHEN ZHUOYUE, YU YUNRU, GUO JIAHUI, SUN LINGYU, ZHAO YUANJIN: "Heterogeneous Structural Color Microfibers for Cardiomyocytes Tug‐of‐War", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 31, no. 9, 24 February 2021 (2021-02-24), DE , pages 2007527, XP055932614, ISSN: 1616-301X, DOI: 10.1002/adfm.202007527
YU YUNRU; SHANG LUORAN; GUO JIAHUI; WANG JIE; ZHAO YUANJIN: "Design of capillary microfluidics for spinning cell-laden microfibers", NATURE PROTOCOLS, NATURE PUBLISHING GROUP, GB, vol. 13, no. 11, 23 October 2018 (2018-10-23), GB , pages 2557 - 2579, XP036624840, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0051-4
YUE YU, WEI WENBO, WANG YAQING, XU CONG, GUO YAQIONG, QIN JIANHUA: "Simple Spinning of Heterogeneous Hollow Microfibers on Chip", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 28, no. 31, DE , pages 6649 - 6655, XP055295173, ISSN: 0935-9648, DOI: 10.1002/adma.201601504
Attorney, Agent or Firm:
NANJING ZHONGSHAN PATENT AGENT CO., LTD. (CN)
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