Title:
STRUCTURAL COLOR MICROFIBER OF HETEROGENEOUS STRUCTURE, PREPARATION METHOD THEREFOR, AND CARDIOMYOCYTE DETECTION METHOD
Document Type and Number:
WIPO Patent Application WO/2022/105869
Kind Code:
A1
Abstract:
A structural color microfiber of a heterogeneous structure, a preparation method therefor, and a cardiomyocyte detection method, the preparation method being: using capillaries to construct a microfluidic chip to be used as a preparation platform for the structural color micro-fiber of a heterogeneous structure, configuring prepolymer liquids as fiber components, and dividing the prepolymer liquids into two types, one type of prepolymer liquid being a biocompatible hydrogel solution (3), and the other type of prepolymer liquid being at least one concentration of a silicon dioxide, non-densely packed colloidal crystal pre-gel (2), a photoinitiator being added into each prepolymer liquid; and the two types of prepolymers being alternately injected in sequence by the microfluidic chip into a collection tube (4), and continuously irradiating the collection tube (4) part by means of ultraviolet light (5) to obtain the structural color microfiber of a heterogeneous structure. Preparation is controllable, costs are cheap, and visualized quantitative sensing of myocyte physiology is achieved.
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Inventors:
ZHAO YUANJIN (CN)
CHEN ZHUOYUE (CN)
WANG YUETONG (CN)
CHI JUNJIE (CN)
ZHANG DAGAN (CN)
SHANG LUORAN (CN)
CHEN ZHUOYUE (CN)
WANG YUETONG (CN)
CHI JUNJIE (CN)
ZHANG DAGAN (CN)
SHANG LUORAN (CN)
Application Number:
PCT/CN2021/131723
Publication Date:
May 27, 2022
Filing Date:
November 19, 2021
Export Citation:
Assignee:
NANJING DRUM TOWER HOSPITAL (CN)
International Classes:
G01N21/78; D01F1/10; D01F6/44; G01B11/16
Foreign References:
CN112485247A | 2021-03-12 | |||
CN107907484A | 2018-04-13 | |||
CN107941678A | 2018-04-20 | |||
CN110542683A | 2019-12-06 | |||
CN110407163A | 2019-11-05 | |||
US20200024560A1 | 2020-01-23 |
Other References:
CHEN ZHUOYUE, YU YUNRU, GUO JIAHUI, SUN LINGYU, ZHAO YUANJIN: "Heterogeneous Structural Color Microfibers for Cardiomyocytes Tug‐of‐War", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 31, no. 9, 24 February 2021 (2021-02-24), DE , pages 2007527, XP055932614, ISSN: 1616-301X, DOI: 10.1002/adfm.202007527
YU YUNRU; SHANG LUORAN; GUO JIAHUI; WANG JIE; ZHAO YUANJIN: "Design of capillary microfluidics for spinning cell-laden microfibers", NATURE PROTOCOLS, NATURE PUBLISHING GROUP, GB, vol. 13, no. 11, 23 October 2018 (2018-10-23), GB , pages 2557 - 2579, XP036624840, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0051-4
YUE YU, WEI WENBO, WANG YAQING, XU CONG, GUO YAQIONG, QIN JIANHUA: "Simple Spinning of Heterogeneous Hollow Microfibers on Chip", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 28, no. 31, DE , pages 6649 - 6655, XP055295173, ISSN: 0935-9648, DOI: 10.1002/adma.201601504
YU YUNRU; SHANG LUORAN; GUO JIAHUI; WANG JIE; ZHAO YUANJIN: "Design of capillary microfluidics for spinning cell-laden microfibers", NATURE PROTOCOLS, NATURE PUBLISHING GROUP, GB, vol. 13, no. 11, 23 October 2018 (2018-10-23), GB , pages 2557 - 2579, XP036624840, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0051-4
YUE YU, WEI WENBO, WANG YAQING, XU CONG, GUO YAQIONG, QIN JIANHUA: "Simple Spinning of Heterogeneous Hollow Microfibers on Chip", ADVANCED MATERIALS, VCH PUBLISHERS, DE, vol. 28, no. 31, DE , pages 6649 - 6655, XP055295173, ISSN: 0935-9648, DOI: 10.1002/adma.201601504
Attorney, Agent or Firm:
NANJING ZHONGSHAN PATENT AGENT CO., LTD. (CN)
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