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Title:
SUBSTITUTED BIS-ARYL AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/098710
Kind Code:
A1
Abstract:
Provided in the present application are a substituted bis-aryl amide compound and a preparation method and an application therefor, the substituted bis-aryl amide compound or a pharmaceutically acceptable salt thereof having the structure of formula [1], R1 being independently selected from hydrogen or substituted or unsubstituted C1-12 linear alkyl, C3-12 branched alkyl, or C3-12 cycloalkyl, R2 being independently selected from -NO2, -NH2, -NHCOR5, -CF3, or -NHSO2NH2; R3 being independently selected from hydrogen, -CF3, -F, -CN, or -NH2; R4 being independently selected from hydrogen or substituted or unsubstituted heterocyclyl; and X being independently selected from hydrogen or nitrogen atoms. The substituted bis-aryl amide compound or pharmaceutically acceptable salt thereof provided in the present application have high anti-hepatitus C virus activity.

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Inventors:
HU LAIXING (CN)
LIU YONGHUA (CN)
PENG ZONGGEN (CN)
LI JIANRUI (CN)
TAN JIALI (CN)
WU YANBIN (CN)
Application Number:
PCT/CN2019/118109
Publication Date:
May 22, 2020
Filing Date:
November 13, 2019
Export Citation:
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Assignee:
INST OF MEDICINAL BIOTECHNOLOGY CHINESE ACADEMY OF MEDICAL SCIENCES & PEKING UNION MEDICAL COLLEGE (CN)
International Classes:
C07D295/135; A61K31/167; A61K31/40; A61K31/495; A61P31/14; C07C235/56; C07D205/04; C07D207/14; C07D213/75
Foreign References:
CN102206172A2011-10-05
CN101309902A2008-11-19
Other References:
DATABASE 0 16 January 2004 (2004-01-16), retrieved from STN Database accession no. 638153-96-5
DATABASE 0 16 January 2004 (2004-01-16), retrieved from STN Database accession no. 638153-92-1
DATABASE 0 9 August 2012 (2012-08-09), retrieved from STN Database accession no. 1388542-13-9
DATABASE 0 15 January 2004 (2004-01-15), retrieved from STN Database accession no. 637730-56-4
DATABASE 0 15 January 2004 (2004-01-15), retrieved from STN Database accession no. 637730-54-2
DATABASE 0 15 January 2004 (2004-01-15), retrieved from STN Database accession no. 637728-73-5
DATABASE 0 15 January 2004 (2004-01-15), retrieved from STN Database accession no. 637728-72-4
Attorney, Agent or Firm:
LEADER PATENT & TRADEMARK FIRM (CN)
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