Title:
SUBSTITUTED GUANIDINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/044186
Kind Code:
A1
Abstract:
Compounds of general formula (1), prodrugs of the same, or pharmaceutically acceptable salts of both are useful as preventive or therapeutic drugs for disease due to increased sodium/proton exchange: (1) wherein R is an optionally substituted benzene ring, a fused polycyclic carbo-ring which may be substituted, an optionally substituted monocyclic hetero-ring, or an optionally substituted polycyclic hetero-ring; A and E are each independently a single bond, lower alkylene, or the like; G is a single bond, oxygen, or the like; and Y is -SO¿3?H or the like.
Inventors:
KITANO MASAHUMI (JP)
YURI MASATOSHI (JP)
OHASHI NAOHITO (JP)
YURI MASATOSHI (JP)
OHASHI NAOHITO (JP)
Application Number:
PCT/JP2000/008669
Publication Date:
June 21, 2001
Filing Date:
December 07, 2000
Export Citation:
Assignee:
SUMITOMO PHARMA (JP)
KITANO MASAHUMI (JP)
YURI MASATOSHI (JP)
OHASHI NAOHITO (JP)
KITANO MASAHUMI (JP)
YURI MASATOSHI (JP)
OHASHI NAOHITO (JP)
International Classes:
A61P9/06; C07D209/42; C07F9/572; C07H17/02; (IPC1-7): C07D209/42; A61K31/403; A61K31/404; A61K31/407; A61K31/437; A61K31/5025; A61K31/5383; A61K31/55; A61K31/675; A61K31/7056; A61P3/10; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P43/00; C07D209/56; C07D209/90; C07D471/06; C07D487/06; C07D498/06; C07F9/572; C07H17/02
Domestic Patent References:
| WO1999055690A1 | 1999-11-04 | |||
| WO1997036859A1 | 1997-10-09 | |||
| WO1994026709A1 | 1994-11-24 |
Foreign References:
| US6169107B1 | 2001-01-02 | |||
| JPH10310582A | 1998-11-24 | |||
| EP0708091A1 | 1996-04-24 | |||
| EP0622356A1 | 1994-11-02 | |||
| EP0381033A1 | 1990-08-08 | |||
| EP0126587A1 | 1984-11-28 | |||
| GB1461948A | 1977-01-19 | |||
| US3154520A | 1964-10-27 |
Other References:
KITANO, MASAFUMI ET AL.: "Synthesis and biological activity of N-(aminoiminomethyl)-1H-indole carboxamide derivatives as Na+/H+ exchanger inhibitors", CHEM. PHARM. BULL., vol. 47, no. 11, 1999, pages 1538 - 1548, XP002937410
SCHMUCK, CARSTEN: "Side chain selective binding of N-acetyl-alpha-amino acid carboxylates by a 2-(guanidiniocarbonyl) pyrrole receptor in aqueous solvents", CHEM. COMMUN., no. 9, 1999, CAMBRIDGE, pages 843 - 844, XP002937411
CHEMICAL ABSTRACTS, vol. 108, 1988, Columbus, Ohio, US; abstract no. 179135W, PIWOWARSKA, B ET AL.: "Preparation and properties of benzoylguanidine and its application in spectrophotometric determination of indium ions" XP002956902
KAMIMURA, SHOJI ET AL.: "Metabolic studies on N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride(guanfacine), a new antihypertensive agent. 2. Metabolities in blood, liver and excreta of rats after signle and repeated oral administration", OYO YAKURI, vol. 20, no. 5, 1980, pages 745 - 751, XP002937412
CHEMICAL ABSTRACTS, vol. 95, Columbus, Ohio, US; abstract no. 99321, XP002944102
PROCACCINI, ROBERT L. ET AL.: "The subcellular distribution of 14C-lidamidine and its metabolites", DRUG METAB. DISPOS., vol. 9, no. 3, 1981, pages 202 - 206, XP002937413
CHEMICAL ABSTRACTS, vol. 55, 1961, Columbus, Ohio, US; SKOWRONSKA-SERAFIN ET AL. column 3480; XP002956903
See also references of EP 1238971A4
SCHMUCK, CARSTEN: "Side chain selective binding of N-acetyl-alpha-amino acid carboxylates by a 2-(guanidiniocarbonyl) pyrrole receptor in aqueous solvents", CHEM. COMMUN., no. 9, 1999, CAMBRIDGE, pages 843 - 844, XP002937411
CHEMICAL ABSTRACTS, vol. 108, 1988, Columbus, Ohio, US; abstract no. 179135W, PIWOWARSKA, B ET AL.: "Preparation and properties of benzoylguanidine and its application in spectrophotometric determination of indium ions" XP002956902
KAMIMURA, SHOJI ET AL.: "Metabolic studies on N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride(guanfacine), a new antihypertensive agent. 2. Metabolities in blood, liver and excreta of rats after signle and repeated oral administration", OYO YAKURI, vol. 20, no. 5, 1980, pages 745 - 751, XP002937412
CHEMICAL ABSTRACTS, vol. 95, Columbus, Ohio, US; abstract no. 99321, XP002944102
PROCACCINI, ROBERT L. ET AL.: "The subcellular distribution of 14C-lidamidine and its metabolites", DRUG METAB. DISPOS., vol. 9, no. 3, 1981, pages 202 - 206, XP002937413
CHEMICAL ABSTRACTS, vol. 55, 1961, Columbus, Ohio, US; SKOWRONSKA-SERAFIN ET AL. column 3480; XP002956903
See also references of EP 1238971A4
Attorney, Agent or Firm:
Asamura, Kiyoshi (New Ohtemachi Bldg. 2-, Ohtemachi 2-chome Chiyoda-ku Tokyo, JP)
Download PDF:
Previous Patent: CARBON MONOXIDE-BASED SYNTHESIS OF SPLA2 INHIBITORS
Next Patent: 4-AMINOPIPERIDINE DERIVATIVES AND THEIR USE AS MEDICINE
Next Patent: 4-AMINOPIPERIDINE DERIVATIVES AND THEIR USE AS MEDICINE