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Title:
SUBSTITUTED HETEROARYL COMPOUNDS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/078294
Kind Code:
A1
Abstract:
The present disclosure provides substituted heteroaryl compounds and use thereof, also provides compounds or pharmaceutically acceptable salts or solvates thereof as PAD inhibitors and their use in treatment of a disease or disorder.

Inventors:
WANG YANMING (CN)
XIA YAN (CN)
SUN JINQUAN (CN)
XIA MINGDE (CN)
Application Number:
PCT/CN2021/123088
Publication Date:
April 21, 2022
Filing Date:
October 11, 2021
Export Citation:
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Assignee:
HELIOS HUAMING BIOPHARMA CO LTD (CN)
International Classes:
A61K31/42; C07D263/32; A61P35/00
Domestic Patent References:
WO2015116896A12015-08-06
WO2018102262A12018-06-07
WO2017007405A12017-01-12
Foreign References:
CN108391432A2018-08-10
Other References:
SUBRAMANIAN VENKATARAMAN, KNIGHT JASON S., PARELKAR SANGRAM, ANGUISH LYNNE, COONROD SCOTT A., KAPLAN MARIANA J., THOMPSON PAUL R.: "Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of Cl-Amidine as Protein Arginine Deiminase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 58, no. 3, 12 February 2015 (2015-02-12), US , pages 1337 - 1344, XP055922617, ISSN: 0022-2623, DOI: 10.1021/jm501636x
MUTH AARON, SUBRAMANIAN VENKATARAMAN, BEAUMONT EDWARD, NAGAR MITESH, KERRY PHILIP, MCEWAN PAUL, SRINATH HEMA, CLANCY KATHLEEN, PAR: "Development of a Selective Inhibitor of Protein Arginine Deiminase 2", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 7, 13 April 2017 (2017-04-13), US , pages 3198 - 3211, XP055922621, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00274
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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