SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2

Title:

SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2

Document Type and Number:

WIPO Patent Application WO2003049698

Kind Code:

A8

Abstract:

Compounds useful as inhibitors of cyclooxygenase-2 activity have the formulae (I) or (Ia) as defined herein. In addition, Figure 2 compares the growth inhibitory activity fo the Example 4 compound 4-bromobenzaldehyde-4-sulfamylphenylhydrazone and celecoxib against the human colo-rectal tumor cell line HT29.

Inventors:

REDDY E PREMKUMAR
REDDY M V RAMANA

Application Number:

PCT/US2002/039343

Publication Date:

September 02, 2004

Filing Date:

December 10, 2002

Export Citation:

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Assignee:

UNIV TEMPLE (US)

International Classes:

A61K31/18; C07D333/22; A61K31/341; A61K31/381; A61K31/40; A61K31/4045; A61K31/44; A61K31/63; A61P9/00; A61P9/10; A61P25/28; A61P29/00; A61P43/00; C07C303/40; C07C311/37; C07C311/39; C07C311/49; C07D209/14; C07D307/52; G02B6/12; G02B6/124; G02B6/125; G02B6/28; G02B6/34; G02B6/35; H04Q11/00; (IPC1-7): A61K31/18

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