Title:
SUBSTITUTED MACROCYCLIC COMPOUNDS HAVING PROTEASOME INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2013/188750
Kind Code:
A3
Abstract:
The disclosure provides for novel compounds which have proteasome inhibitory activity, pharmaceutical compositions made thereof, and methods of use thereof to treat various disorders, including cancer and nonmalignant tumors.
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Inventors:
PIRRUNG MICHAEL C (US)
Application Number:
PCT/US2013/045854
Publication Date:
February 13, 2014
Filing Date:
June 14, 2013
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
C07D245/02; A61K31/395; A61P35/00
Domestic Patent References:
| WO2011069045A2 | 2011-06-09 |
Other References:
ANSHU, ASHISH ET AL.: "Novel proteasome-inhibitory syrbactin analogs inducing endoplasmic reticulum stress and apoptosis in hematological tumor cell lines", BIOCHEMICAL PHARMACOLOGY, vol. 82, no. 6, 2011, pages 600 - 609, XP028256403
ARCHER, CRYSTAL R. ET AL.: "Syrbactin class proteasome inhibitor-induced apoptosis and autophagy occurs in association with p53 accumulation and Akt/PKB activation in neuroblastoma", BIOCHEMICAL PHARMACOLOGY, vol. 80, no. 2, 2010, pages 170 - 178, XP055181771
See also references of EP 2861565A4
ARCHER, CRYSTAL R. ET AL.: "Syrbactin class proteasome inhibitor-induced apoptosis and autophagy occurs in association with p53 accumulation and Akt/PKB activation in neuroblastoma", BIOCHEMICAL PHARMACOLOGY, vol. 80, no. 2, 2010, pages 170 - 178, XP055181771
See also references of EP 2861565A4
Attorney, Agent or Firm:
BAKER, JR., Joseph, R. (Dodd & Lindsey LLP4660 La Jolla Village Drive, Suite 75, San Diego CA, US)
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