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Title:
SUBSTITUTED TETRACYCLIC PYRIDOINDOLES AS SEROTONIN AGONISTS AND ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2002059129
Kind Code:
A3
Abstract:
The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R<1>, R<5>, R<6>, R<7>, R<8>, R<9>, X, b, k, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.

Inventors:
ROBICHAUD ALBERT J
FEVIG JOHN M
MITCHELL IAN S
LEE TAEKYU
CHEN WENTING
CACCIOLA JOSEPH
Application Number:
PCT/US2001/049371
Publication Date:
January 30, 2003
Filing Date:
December 19, 2001
Export Citation:
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Assignee:
SQUIBB BRISTOL MYERS CO (US)
International Classes:
C07D513/00; A61K31/551; A61K31/553; A61K31/554; A61P1/00; A61P3/04; A61P25/00; A61P25/06; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D471/16; C07D498/16; C07D513/16; (IPC1-7): C07D471/16; C07D513/16; C07D498/16; A61K31/55; A61P25/00
Domestic Patent References:
WO2000064899A12000-11-02
WO2000077001A12000-12-21
WO2000077010A22000-12-21
Foreign References:
US4238607A1980-12-09
US4183936A1980-01-15
US4115577A1978-09-19
US3914421A1975-10-21
US3299078A1967-01-17
US6407092B12002-06-18
Other References:
HOYER D ET AL: "VII. INTERNATIONAL UNION OF PHAMACOLOGY CLASSIFICATION OF RECEPTORS FOR 5-HYDROXYTRYPTAMINE (SEROTONIN)", PHARMACOLOGICAL REVIEWS, WILLIAMS AND WILKINS INC., BALTIMORE, MD,, US, vol. 46, no. 2, 1 June 1994 (1994-06-01), pages 157 - 203, XP000604197, ISSN: 0031-6997
JENCK,F. ET AL.: "The role of 5-HT2C receptors in affective disorders", EXP.OPIN.THER.PATENTS, vol. 7, no. 10, 1998, LONDON, pages 1587 - 1599, XP002210253
MARTIN,J.R. ET AL.: "5-HT2C Receptor Agonists : Pharmacological Characteristics and Therapeutic Potential", J.PHARMACOL.EXP.THER., vol. 286, no. 2, August 1996 (1996-08-01), BALTIMORE, pages 913 - 924, XP002210254
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