Title:
SUBSTITUTED TRIAZINONES AS THYROID HORMONE RECEPTOR AGONISTS
Document Type and Number:
WIPO Patent Application WO/2021/143706
Kind Code:
A1
Abstract:
The application relates to a compound of Formula (I') or (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of thyroid hormone receptors, a pharmaceutical composition comprising a compound of Formula (I') or (I), and a method of treating or preventing a disease or disorder regulated by thyroid hormone.
Inventors:
ZHOU JINGYE (CN)
ZHU JIUXIANG (CN)
ZHENG MINGWEI (CN)
ZHU JIUXIANG (CN)
ZHENG MINGWEI (CN)
Application Number:
PCT/CN2021/071381
Publication Date:
July 22, 2021
Filing Date:
January 13, 2021
Export Citation:
Assignee:
ECCOGENE SHANGHAI CO LTD (CN)
International Classes:
C07D253/075; A61K31/53; A61P3/00; A61P5/00; A61P35/00; C07D401/12; C07D403/12; C07D405/12; C07D405/14
Domestic Patent References:
| WO2020169069A1 | 2020-08-27 |
Foreign References:
| JP2012106996A | 2012-06-07 | |||
| EP1088819A2 | 2001-04-04 | |||
| US4522811A | 1985-06-11 |
Other References:
AMIT A. JOHARAPURKAR ET AL: "Selective Thyromimetics Using Receptor and Tissue Selectivity Approaches: Prospects for Dyslipidemia", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 12, 1 May 2012 (2012-05-01), US, pages 5649 - 5675, XP055545391, ISSN: 0022-2623, DOI: 10.1021/jm2004706
DANZI S AND I KLEIN: "Cardiac specific effects of thyroid hormone analogues", HORMONE AND METABOLIC RESEARCH, THIEME-STRATTON, STUTTGART, DE, vol. 43, no. 11, 31 October 2011 (2011-10-31), pages 737 - 742, XP009524228, ISSN: 0018-5043, DOI: 10.1055/S-0031-1291177
LIU ET AL: "QSAR study of selective ligands for the thyroid hormone receptor @b", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 15, no. 15, 8 June 2007 (2007-06-08), pages 5251 - 5261, XP022110127, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2007.05.016
CAHN ET AL., ANGEW. CHEM. INTER. EDIT., vol. 5, 1966, pages 385
CAHN ET AL., ANGEW. CHEM., vol. 78, 1966, pages 413
CAHNINGOLD, J. CHEM. SOC., vol. 612, 1951
CAHN ET AL., EXPERIENTIA, vol. 12, 1956, pages 81
CAHN, J. CHEM. EDUC., vol. 41, 1964, pages 116
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY
E. L. ELIELS. H. WILENL. N. MANDER: "Stereochemistry of Organic Compounds", 1994, WILEY-LNTERSCIENCE
BUNDEGAARD, H.: "Design of Prodrugs", 1985, ELSEVIER, pages: 1 - 92
"Remington: the Science and Practice of Pharmacy", 1995, MACK PUBLISHING CO.
DANZI S AND I KLEIN: "Cardiac specific effects of thyroid hormone analogues", HORMONE AND METABOLIC RESEARCH, THIEME-STRATTON, STUTTGART, DE, vol. 43, no. 11, 31 October 2011 (2011-10-31), pages 737 - 742, XP009524228, ISSN: 0018-5043, DOI: 10.1055/S-0031-1291177
LIU ET AL: "QSAR study of selective ligands for the thyroid hormone receptor @b", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 15, no. 15, 8 June 2007 (2007-06-08), pages 5251 - 5261, XP022110127, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2007.05.016
CAHN ET AL., ANGEW. CHEM. INTER. EDIT., vol. 5, 1966, pages 385
CAHN ET AL., ANGEW. CHEM., vol. 78, 1966, pages 413
CAHNINGOLD, J. CHEM. SOC., vol. 612, 1951
CAHN ET AL., EXPERIENTIA, vol. 12, 1956, pages 81
CAHN, J. CHEM. EDUC., vol. 41, 1964, pages 116
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY
E. L. ELIELS. H. WILENL. N. MANDER: "Stereochemistry of Organic Compounds", 1994, WILEY-LNTERSCIENCE
BUNDEGAARD, H.: "Design of Prodrugs", 1985, ELSEVIER, pages: 1 - 92
"Remington: the Science and Practice of Pharmacy", 1995, MACK PUBLISHING CO.
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
Download PDF:
Previous Patent: METHOD AND APPARATUS FOR RANDOM ACCESS
Next Patent: DUAL-MODALITY MICROSCOPIC IMAGING SYSTEM AND METHOD
Next Patent: DUAL-MODALITY MICROSCOPIC IMAGING SYSTEM AND METHOD