Title:
SUCCINIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2003004460
Kind Code:
A3
Abstract:
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.
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Inventors:
ROELLE THOMAS (DE)
LEHMANN THOMAS (DE)
ALBERS MARKUS (DE)
MUELLER GERHARD (DE)
HESSLER GERHARD (DE)
FISCHER RUEDIGER (DE)
TAJIMI MASAOMI (JP)
ZIEGELBAUER KARL (DE)
BACON KEVIN (JP)
HASEGAWA HARUKI (JP)
OKIGAMI HIROMI (JP)
LEHMANN THOMAS (DE)
ALBERS MARKUS (DE)
MUELLER GERHARD (DE)
HESSLER GERHARD (DE)
FISCHER RUEDIGER (DE)
TAJIMI MASAOMI (JP)
ZIEGELBAUER KARL (DE)
BACON KEVIN (JP)
HASEGAWA HARUKI (JP)
OKIGAMI HIROMI (JP)
Application Number:
PCT/EP2002/006941
Publication Date:
December 11, 2003
Filing Date:
June 24, 2002
Export Citation:
Assignee:
BAYER HEALTHCARE AG (DE)
ROELLE THOMAS (DE)
LEHMANN THOMAS (DE)
ALBERS MARKUS (DE)
MUELLER GERHARD (DE)
HESSLER GERHARD (DE)
FISCHER RUEDIGER (DE)
TAJIMI MASAOMI (JP)
ZIEGELBAUER KARL (DE)
BACON KEVIN (JP)
HASEGAWA HARUKI (JP)
OKIGAMI HIROMI (JP)
ROELLE THOMAS (DE)
LEHMANN THOMAS (DE)
ALBERS MARKUS (DE)
MUELLER GERHARD (DE)
HESSLER GERHARD (DE)
FISCHER RUEDIGER (DE)
TAJIMI MASAOMI (JP)
ZIEGELBAUER KARL (DE)
BACON KEVIN (JP)
HASEGAWA HARUKI (JP)
OKIGAMI HIROMI (JP)
International Classes:
A61P9/10; A61P11/06; A61P29/00; A61P37/00; C07C233/55; C07C275/40; (IPC1-7): C07C275/40; A61K31/17; A61P9/10; C07C233/55
Domestic Patent References:
| WO1998004247A1 | 1998-02-05 |
Foreign References:
| AT205017B | 1959-08-25 | |||
| EP0125106A1 | 1984-11-14 |
Other References:
COOPER G H ET AL: "REDUCTIVE ACYLATION OF 5-NITROPYRIDINES WITH ANHYDRIDES OF ACETIC, PHTHALIC, AND SUCCINIC ACIDS", JOURNAL OF THE CHEMICAL SOCIETY, SECTION C: ORGANIC CHEMISTRY, CHEMICAL SOCIETY. LETCHWORTH, GB, no. 19, 1971, pages 3257 - 3260, XP000996536, ISSN: 0022-4952
NAVARRO H.A. ET AL.: "SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF [125IIODOMETHYLLYCACONITINE ([125I]IODO-MLA). A NEW LIGAND FOR THE ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR", J. MED. CHEM., vol. 43, no. 2, 2000, pages 142 - 145, XP002231242
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CHERNIKH, V. P. ET AL: "Synthesis of 1,1-dioxo-2H-1,2,4-benzothiadiazine-3-propionic acid", XP002231243, retrieved from STN Database accession no. 107:96683
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KONEV, V. F. ET AL: "A basis for the search for biologically active compounds among 4-sulfamylsuccinanilic acids", XP002231244, retrieved from STN Database accession no. 108:87582
FLITSCH W. ET AL.: "MITOMYCIN ANTIBIOTICS: SYNTHESIS OF 9A-FUNCTIONALIZED MITOSANES", HETEROCYCLES, vol. 22, no. 3, 1984, pages 541 - 544, XP008013927
NAVARRO H.A. ET AL.: "SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF [125IIODOMETHYLLYCACONITINE ([125I]IODO-MLA). A NEW LIGAND FOR THE ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR", J. MED. CHEM., vol. 43, no. 2, 2000, pages 142 - 145, XP002231242
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CHERNIKH, V. P. ET AL: "Synthesis of 1,1-dioxo-2H-1,2,4-benzothiadiazine-3-propionic acid", XP002231243, retrieved from STN Database accession no. 107:96683
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KONEV, V. F. ET AL: "A basis for the search for biologically active compounds among 4-sulfamylsuccinanilic acids", XP002231244, retrieved from STN Database accession no. 108:87582
FLITSCH W. ET AL.: "MITOMYCIN ANTIBIOTICS: SYNTHESIS OF 9A-FUNCTIONALIZED MITOSANES", HETEROCYCLES, vol. 22, no. 3, 1984, pages 541 - 544, XP008013927
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