Title:
SUGAR-ADDED OSPEMIFENE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/031754
Kind Code:
A1
Abstract:
The present invention relates to a novel ospemifene derivative compound in which a sugar is added to ospemifene as one kind of selective estrogen receptor modulator (hereinafter, SERM), and to a preparation method for the compound. The ospemifene derivative compound has improved bioavailability compared with existing ospemifene, and also has partially improved bioavailability compared with the original compound ospemifene, which provides a disease treatment effect for dyspareunia, vaginal dryness, and the like appearing in menopausal women, and thus can be favorably used as a modified dosage form.
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Inventors:
PARK JE WON (KR)
Application Number:
PCT/KR2018/008662
Publication Date:
February 14, 2019
Filing Date:
July 31, 2018
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07H15/203; C12P19/18; C12P19/46
Domestic Patent References:
| WO1996007402A1 | 1996-03-14 |
Foreign References:
| KR20170011543A | 2017-02-02 | |||
| KR20080015924A | 2008-02-20 | |||
| KR20170011542A | 2017-02-02 |
Other References:
TOLONEN, A.: "Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations", DRUG METABOLISM AND PERSONALIZED THERAPY, vol. 28, no. 3, 2013, pages 153 - 161
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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