Title:
SULFO-SUBSTITUTED BIARYL COMPOUND OR SALT THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/063362
Kind Code:
A1
Abstract:
The present invention relates to a sulfo-substituted biaryl derivative compound or a salt thereof, a preparation method therefor, and a use thereof. In particular, the present invention relates to a compound of formula (I) or a stereoisomer, tautomer, stable isotopic derivative, pharmaceutically acceptable salt, or solvate thereof, where R 1, R 2, R 3, R 4, R 5, R 5', R 6, R 7, and X are as defined in the description. The present invention also relates to a preparation method for the compound, a pharmaceutical composition comprising same, and a use of the compound in preparing a drug for treating or preventing a disease related to RORγt.
Inventors:
CHENG YAOBANG (CN)
HUANG YAFEI (CN)
ZHOU JUAN (CN)
DONG ZHIQIANG (CN)
HUANG YAFEI (CN)
ZHOU JUAN (CN)
DONG ZHIQIANG (CN)
Application Number:
PCT/CN2020/118905
Publication Date:
April 08, 2021
Filing Date:
September 29, 2020
Export Citation:
Assignee:
SHANGHAI LITEDD CO LTD (CN)
International Classes:
C07C309/32; A61K31/167; A61K31/4412; A61P31/12; A61P35/00; A61P37/02; C07D213/71
Domestic Patent References:
| WO2013029338A1 | 2013-03-07 | |||
| WO2017157332A1 | 2017-09-21 | |||
| WO2019007382A1 | 2019-01-10 | |||
| WO2015171558A2 | 2015-11-12 | |||
| WO2016179343A1 | 2016-11-10 |
Foreign References:
| CN108863850A | 2018-11-23 | |||
| CA2572334A1 | 2006-01-19 |
Other References:
DONG CHEN, IMMUNITY, vol. 31, 2009, pages 787 - 798
ACS CHEM. BIOL., vol. 11, 2016, pages 1012 - 1018
J. MED. CHEM., vol. 61, 2018, pages 5794 - 5804
ONCOIMMUNOLOGY, vol. 5, no. 12, 2016, pages e1254854
KERNS, EDWARD H.DI LI: "Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization", 2008, ACADEMIC PRESS
DI, LI ET AL.: "Optimization of a Higher Throughput Microsomal Stability Screening Assay for Profiling Drug Discovery Candidates", J. BIOMOL. SCREEN., 2003
ACS CHEM. BIOL., vol. 11, 2016, pages 1012 - 1018
J. MED. CHEM., vol. 61, 2018, pages 5794 - 5804
ONCOIMMUNOLOGY, vol. 5, no. 12, 2016, pages e1254854
KERNS, EDWARD H.DI LI: "Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization", 2008, ACADEMIC PRESS
DI, LI ET AL.: "Optimization of a Higher Throughput Microsomal Stability Screening Assay for Profiling Drug Discovery Candidates", J. BIOMOL. SCREEN., 2003
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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