Title:
SULFONYL BENZAMIDE DERIVATIVES AS BCL-2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2022/161496
Kind Code:
A1
Abstract:
The present disclosure provides compounds having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein variables are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition, particiularly Bcl-2 WT and/or Bcl-2 G101V.
Inventors:
LI DONGBO (CN)
CHEN JIANYONG (CN)
LIU FANG (CN)
CHEN HAO (CN)
ZHA XIANCHAN (CN)
CHEN JIANYONG (CN)
LIU FANG (CN)
CHEN HAO (CN)
ZHA XIANCHAN (CN)
Application Number:
PCT/CN2022/075239
Publication Date:
August 04, 2022
Filing Date:
January 30, 2022
Export Citation:
Assignee:
ASCENTAGE PHARMA SUZHOU CO LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/496; A61K31/635; A61P35/00; C07D405/12; C07D405/14; C07D407/14; C07D409/14
Domestic Patent References:
| WO2020088442A1 | 2020-05-07 | |||
| WO2020238785A1 | 2020-12-03 | |||
| WO2019185025A1 | 2019-10-03 |
Foreign References:
| CN113444078A | 2021-09-28 | |||
| CN108658983A | 2018-10-16 | |||
| CN1906183A | 2007-01-31 | |||
| CN102947283A | 2013-02-27 | |||
| CN102307872A | 2012-01-04 | |||
| CN105026394A | 2015-11-04 | |||
| CN110177788A | 2019-08-27 |
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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