Title:
SURFACE LINKER OF SEMICONDUCTOR CHIP, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/022480
Kind Code:
A1
Abstract:
The present invention relates to the field of biochips, and provides a surface linker for a semiconductor chip, a preparation method therefor and an application thereof. The chip surface linker reacts with a chip surface by means of using silanized molecules as a solute and toluene as a solvent so as to form bonding molecules connected to the chip surface, and is prepared by reacting with functionalized molecules to modify a hydroxyl group and an ester group. The chip surface linker obtained by the present invention may be stably bonded to the chip surface, is stable under acidic and alkaline conditions, has good electrical conductivity, electrical stability and resistance to organic solvents required for nucleic acid synthesis, and is extremely advantageous for subsequent nucleic acid synthesis and other applications.
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Inventors:
HU FEICHI (CN)
LIU CHUNYAN (CN)
WU CHENG-HSIEN (CN)
LIN YONGLONG (CN)
LIU CHUNYAN (CN)
WU CHENG-HSIEN (CN)
LIN YONGLONG (CN)
Application Number:
PCT/CN2021/108534
Publication Date:
February 03, 2022
Filing Date:
July 27, 2021
Export Citation:
Assignee:
NANJING GENSCRIPT BIOTECH CO LTD (CN)
International Classes:
H01L21/00
Foreign References:
| US20070065834A1 | 2007-03-22 | |||
| US20110154648A1 | 2011-06-30 | |||
| CN103335984A | 2013-10-02 | |||
| CN1627069A | 2005-06-15 |
Other References:
HU WEIWEN, HU QIONG, LI LIANZHI, KONG JINMING, ZHANG XUEJI: "Detection of sequence-specific DNA with a morpholino-functionalized silicon chip", ANALYTICAL METHODS, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 7, no. 6, 1 January 2015 (2015-01-01), GB , pages 2406 - 2412, XP055892646, ISSN: 1759-9660, DOI: 10.1039/C4AY02780A
MALKI, MAAYAN ET AL.: "Thin electroless Co (W, P) film growth on titanium-nitride layer modified by self-assembled monolayer", SURFACE AND COATINGS TECHNOLOGY, vol. 252, 2014, pages 1 - 7, XP028849156, DOI: 10.1016/j.surfcoat.2014.04.041
ZEB, GUL ET AL.: "On the chemical grafting of titanium nitride by diazonium chemistry", RSC ADVANCES, vol. 5, no. 62, 2015, pages 50298 - 50305
QIU, GUANGYUSIU PANG NGCHI-MAN LAWRENCE WU.: "Label-free surface plasmon resonance biosensing with titanium nitride thin film", BIOSENSORS AND BIOELECTRONICS, vol. 106, 2018, pages 129 - 135
LONNBERG H: "Synthesis of oligonucleotides on a soluble support[J", BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 13, no. 1, 2017, pages 1368 - 1387, XP055798685, DOI: 10.3762/bjoc.13.134
MALKI, MAAYAN ET AL.: "Thin electroless Co (W, P) film growth on titanium-nitride layer modified by self-assembled monolayer", SURFACE AND COATINGS TECHNOLOGY, vol. 252, 2014, pages 1 - 7, XP028849156, DOI: 10.1016/j.surfcoat.2014.04.041
ZEB, GUL ET AL.: "On the chemical grafting of titanium nitride by diazonium chemistry", RSC ADVANCES, vol. 5, no. 62, 2015, pages 50298 - 50305
QIU, GUANGYUSIU PANG NGCHI-MAN LAWRENCE WU.: "Label-free surface plasmon resonance biosensing with titanium nitride thin film", BIOSENSORS AND BIOELECTRONICS, vol. 106, 2018, pages 129 - 135
LONNBERG H: "Synthesis of oligonucleotides on a soluble support[J", BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 13, no. 1, 2017, pages 1368 - 1387, XP055798685, DOI: 10.3762/bjoc.13.134
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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