Title:
SYNTHESIS OF 3-BROMO-5-(2-ETHYLIMIDAZO[1,2-α]PYRIDINE-3-CARBONYL)-2-HYDROXYBENZONITRILE
Document Type and Number:
WIPO Patent Application WO/2020/147803
Kind Code:
A1
Abstract:
Disclosed in the present invention is a synthesis method for 3-bromo-5-(2-ethylimidazo[1,2-α]pyridine-3-carbonyl)-2-hydroxybenzonitrile, relating in particular to a synthesis method for a compound represented by formula (III), which specifically involves step A or step B; step A comprises: a compound represented by formula (I) and a compound represented by formula (II) first reacting by means of heating in an organic solvent, and a resulting reaction product and a base are further being heated in the presence of water to continue reacting so as to obtain a compound represented by formula (III); Step B comprises: the compound represented by formula (I), the compound represented by formula (II) and a base first reacting by means of heating in an organic solvent, and a resulting reaction product then being heated in the presence of water to continue reacting so as to obtain the compound represented by formula (III).
Inventors:
SHI DONGFANG (CN)
FU CHANGJIN (CN)
GU JIE (CN)
ZHANG MIN (CN)
GONG WEIWEI (CN)
LI PENGFEI (CN)
FU CHANGJIN (CN)
GU JIE (CN)
ZHANG MIN (CN)
GONG WEIWEI (CN)
LI PENGFEI (CN)
Application Number:
PCT/CN2020/072582
Publication Date:
July 23, 2020
Filing Date:
January 17, 2020
Export Citation:
Assignee:
JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/04
Domestic Patent References:
| WO2018090921A1 | 2018-05-24 |
Foreign References:
| CN201610810990A | 2016-09-08 |
Other References:
See also references of EP 3915984A4
Attorney, Agent or Firm:
NANJING SITUO INTELLECTUAL PROPERTY AGENCY (GP) (CN)
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