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Title:
SYNTHESIS OF EPOTHILONES INTERMEDIATES THERETO AND ANALOGUES THEREOF
Document Type and Number:
WIPO Patent Application WO2003022844
Kind Code:
A3
Abstract:
The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula(I).

Inventors:
DANISHEFSKY SAMUEL J (US)
BISWAS KAUSTAV (US)
CHAPELL MARK (US)
LIN HONG (US)
NJARDARSON JON T (US)
LEE CHULBOM (US)
RIVKIN ALEXEY (US)
CHOU TING-CHAO (US)
Application Number:
PCT/US2002/028425
Publication Date:
March 04, 2004
Filing Date:
September 06, 2002
Export Citation:
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Assignee:
SLOAN KETTERING INST CANCER (US)
DANISHEFSKY SAMUEL J (US)
BISWAS KAUSTAV (US)
CHAPELL MARK (US)
LIN HONG (US)
NJARDARSON JON T (US)
LEE CHULBOM (US)
RIVKIN ALEXEY (US)
CHOU TING-CHAO (US)
International Classes:
A61K31/365; A61K31/38; A61K31/427; A61K31/7048; A61P35/00; C07D413/06; C07D417/02; C07D417/06; C07D493/04; C07D493/08; C07H17/08; (IPC1-7): C07D419/06; C07D413/06; C07D493/04; A61K31/42; A61K31/425; A61P35/00
Domestic Patent References:
WO2002080846A22002-10-17
WO2001092255A22001-12-06
WO2001083800A22001-11-08
WO1999007692A21999-02-18
Foreign References:
DE19908767A12000-10-19
DE19826988A11999-12-23
DE19908760A12000-08-24
Other References:
HARDT, INGO H. ET AL: "New Natural Epothilones from Sorangium cellulosum, Strains So ce90/B2 and So ce90/D13: Isolation, Structure Elucidation, and SAR Studies", JOURNAL OF NATURAL PRODUCTS (2001), 64(7), 847-856, XP002220541
NICOLAOU K C ET AL: "Chemical Biology of Epothilones", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, VERLAG CHEMIE. WEINHEIM, DE, vol. 37, no. 15, August 1998 (1998-08-01), pages 2014 - 2045, XP002131418, ISSN: 0570-0833
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