Title:
SYNTHESIS OF INHIBITORS OF P90RSK
Document Type and Number:
WIPO Patent Application WO2006086103
Kind Code:
A3
Abstract:
The synthesis of the naturally occurring kaempferol glycoside SLO1O1-1, as well as analogs thereof, has been accomplished, as has its biochemical evaluation. SLO1O1-1 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthetic scheme of the invention verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.
Inventors:
HECHT SIDNEY M (US)
MALONEY DAVID (US)
MALONEY DAVID (US)
Application Number:
PCT/US2006/000709
Publication Date:
September 28, 2006
Filing Date:
January 10, 2006
Export Citation:
Assignee:
UNIV VIRGINIA (US)
HECHT SIDNEY M (US)
MALONEY DAVID (US)
HECHT SIDNEY M (US)
MALONEY DAVID (US)
International Classes:
A01N43/04; A61K31/70; C07H15/00; C07H17/00
Domestic Patent References:
| WO2003105766A2 | 2003-12-24 |
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