Title:
SYNTHESIS AND USE OF 2'-SUBSTITUTED-N6-MODIFIED NUCLEOSIDES
Document Type and Number:
WIPO Patent Application WO2004065398
Kind Code:
A3
Abstract:
An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.
Inventors:
AN HAOYUN (US)
RAMASAMY KANDA (US)
SHAW STEPHANIE (US)
RAMASAMY KANDA (US)
SHAW STEPHANIE (US)
Application Number:
PCT/US2004/001125
Publication Date:
March 03, 2005
Filing Date:
January 15, 2004
Export Citation:
Assignee:
RIBAPHARM INC (US)
AN HAOYUN (US)
RAMASAMY KANDA (US)
SHAW STEPHANIE (US)
AN HAOYUN (US)
RAMASAMY KANDA (US)
SHAW STEPHANIE (US)
International Classes:
C07H19/16; (IPC1-7): A01N43/04; A61K31/70
Domestic Patent References:
| WO2004028841A1 | 2004-04-08 | |||
| WO2003062256A1 | 2003-07-31 | |||
| WO2004065398A2 | 2004-08-05 |
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