Title:
SYNTHETIC DERIVATIVES OF CHOLIC ACID 7-SULFATE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/117945
Kind Code:
A8
Abstract:
The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), or an inflammatory disease (e.g., Crohn's disease, inflammatory bowel disease, ulcerative colitis, pancreatitis, hepatitis, appendicitis, gastritis, diverticulitis, celiac disease, food intolerance, enteritis, ulcer, gastroesophageal reflux disease (GERD), psoriatic arthritis, psoriasis, and rheumatoid arthritis) in a subject in need thereof comprising administering to a subject a compound of Formulae (I)-(XVII).
Inventors:
DEVLIN ABIGAIL SLOAN (US)
CHAUDHARI SNEHAL (US)
SHEU ERIC GARLAND (US)
HARRIS DAVID A (US)
LEE JINBO (US)
CHAUDHARI SNEHAL (US)
SHEU ERIC GARLAND (US)
HARRIS DAVID A (US)
LEE JINBO (US)
Application Number:
PCT/US2019/064488
Publication Date:
July 02, 2020
Filing Date:
December 04, 2019
Export Citation:
Assignee:
HARVARD COLLEGE (US)
BRIGHAM & WOMENS HOSPITAL INC (US)
BRIGHAM & WOMENS HOSPITAL INC (US)
International Classes:
A61K31/575; C07J9/00
Attorney, Agent or Firm:
BAKER, C., Hunter et al. (US)
Download PDF:
Previous Patent: POWER EFFICIENT RADIO FREQUENCY (RF) MULTIPLIERS
Next Patent: GROUNDWATER ENHANCED GEOTHERMAL HEAT PUMP
Next Patent: GROUNDWATER ENHANCED GEOTHERMAL HEAT PUMP