Title:
SYNTHETIC METHOD FOR NMN DERIVATIVE AND MEDICAL APPLICATIONS OF NMN AND ITS DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/098725
Kind Code:
A1
Abstract:
It relates to use of nicotinamide mononucleotide, in particular, relates to use of nicotinamide mononucleotide for the preparation of a medicament for preventing or alleviating liver injury or liver fibrosis in a subject, and a method for preventing liver injury or liver fibrosis in a subject. It also relates to a method of producing dihydronicotinamide mononucleotide (NMNH) and uses of NMNH.
Inventors:
DENG HAITENG (CN)
LIU YAN (CN)
ZONG ZHAOYUN (CN)
LI TING (CN)
LIU JING (CN)
ZHANG WENHAO (CN)
CHEN YULING (CN)
LIU XIAOHUI (CN)
LIU YAN (CN)
ZONG ZHAOYUN (CN)
LI TING (CN)
LIU JING (CN)
ZHANG WENHAO (CN)
CHEN YULING (CN)
LIU XIAOHUI (CN)
Application Number:
PCT/CN2020/129788
Publication Date:
May 27, 2021
Filing Date:
November 18, 2020
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C07H19/048; A61K31/706; A61P1/16; A61P3/04; A61P29/00; A61P35/00
Domestic Patent References:
| WO2017079195A1 | 2017-05-11 | |||
| WO2018236814A2 | 2018-12-27 |
Other References:
LIU YAN: "Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth", BIORVIX, 9 November 2020 (2020-11-09), pages 1 - 40
PLAPP BRYCE V, SOGIN DAVID C, DWORSCHACK ROBERT T, BOHLKEN DAVID P, WOENCKHAUS CHRISTOPH, JECK REINHARD: "Kinetics of Native and Modified Liver Alcohol Dehydrogenase with Coenzyme Analogues: Isomerization of Enzyme-Nicotinamide Adenine Dinucleotide Complex.", BIOCHEMISTRY, vol. 25, no. 19, 31 December 1986 (1986-12-31), pages 5396 - 5402, XP055814016, ISSN: 0006-2960
SHUTSUNG LAO , JOHN T DULANEY , H G WILLIAMS-ASHAMN: "Purification and Properties of a Flavoprotein Catalyzing the Oxidation of Reduced Ribosyl Nicotinamide", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 237, no. 9, 1 September 1962 (1962-09-01), pages 2981 - 2987, XP008034142, ISSN: 0021-9258
FELICIA YING-HSIUEH WU , ROBERT E MACKENZIE , DONALD B MCCORMICK: "Kinetics and Mechanism of Oxidation-Reduction Reactions between Pyridine Nucleotides and Flavins.", BIOCHEMISTRY, vol. 9, no. 11, 26 May 1970 (1970-05-26), pages 2219 - 2224, XP055814025, ISSN: 0006-2960, DOI: 10.1021/bi00813a001
SHASHOUA VICTOR E: "Formamidine Sulfinic Acid as a Biochemical Reducing Agent.", BIOCHEMISTRY, vol. 3, no. 11, 30 November 1964 (1964-11-30), pages 1719 - 1720, XP055814032
PLAPP BRYCE V, SOGIN DAVID C, DWORSCHACK ROBERT T, BOHLKEN DAVID P, WOENCKHAUS CHRISTOPH, JECK REINHARD: "Kinetics of Native and Modified Liver Alcohol Dehydrogenase with Coenzyme Analogues: Isomerization of Enzyme-Nicotinamide Adenine Dinucleotide Complex.", BIOCHEMISTRY, vol. 25, no. 19, 31 December 1986 (1986-12-31), pages 5396 - 5402, XP055814016, ISSN: 0006-2960
SHUTSUNG LAO , JOHN T DULANEY , H G WILLIAMS-ASHAMN: "Purification and Properties of a Flavoprotein Catalyzing the Oxidation of Reduced Ribosyl Nicotinamide", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 237, no. 9, 1 September 1962 (1962-09-01), pages 2981 - 2987, XP008034142, ISSN: 0021-9258
FELICIA YING-HSIUEH WU , ROBERT E MACKENZIE , DONALD B MCCORMICK: "Kinetics and Mechanism of Oxidation-Reduction Reactions between Pyridine Nucleotides and Flavins.", BIOCHEMISTRY, vol. 9, no. 11, 26 May 1970 (1970-05-26), pages 2219 - 2224, XP055814025, ISSN: 0006-2960, DOI: 10.1021/bi00813a001
SHASHOUA VICTOR E: "Formamidine Sulfinic Acid as a Biochemical Reducing Agent.", BIOCHEMISTRY, vol. 3, no. 11, 30 November 1964 (1964-11-30), pages 1719 - 1720, XP055814032
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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