Title:
SYNTHETIC RNA-BASED AGONISTS OF TLR7
Document Type and Number:
WIPO Patent Application WO/2010/093705
Kind Code:
A3
Abstract:
The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability and that selectively induce immune modulatory activity through TLR7.
Inventors:
LAN TAO (US)
KANDIMALLA EKAMBAR R (US)
WANG DAQING (US)
AGRAWAL SUDHIR (US)
KANDIMALLA EKAMBAR R (US)
WANG DAQING (US)
AGRAWAL SUDHIR (US)
Application Number:
PCT/US2010/023769
Publication Date:
November 11, 2010
Filing Date:
February 10, 2010
Export Citation:
Assignee:
IDERA PHARMACEUTICALS INC (US)
LAN TAO (US)
KANDIMALLA EKAMBAR R (US)
WANG DAQING (US)
AGRAWAL SUDHIR (US)
LAN TAO (US)
KANDIMALLA EKAMBAR R (US)
WANG DAQING (US)
AGRAWAL SUDHIR (US)
International Classes:
C12N15/117; A61K39/39; A61K31/7115; A61K31/7125; C07H21/02
Domestic Patent References:
| WO2009014887A2 | 2009-01-29 | |||
| WO2008139262A2 | 2008-11-20 | |||
| WO2007117686A2 | 2007-10-18 |
Foreign References:
Other References:
LAN TAO ET AL: "Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), vol. 104, no. 34, 21 August 2007 (2007-08-21), pages 13750 - 13755, XP002494199, ISSN: 0027-8424
KANDIMALLA E R ET AL: "Divergent synthetic nucleotide motif recognition pattern: design and developmentof potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles", NUCLEIC ACIDS RESEARCH, vol. 31, no. 9, 1 January 2003 (2003-01-01), pages 2393 - 2400, XP002989074, ISSN: 0305-1048
LAN TAO ET AL: "Toll-like Receptor 7 Selective Synthetic Oligoribonucleotide Agonists: Synthesis and Structure-Activity Relationship Studies", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 21, November 2009 (2009-11-01), pages 6871 - 6879, XP002598928, ISSN: 0022-2623
KANDIMALLA E R ET AL: "Divergent synthetic nucleotide motif recognition pattern: design and developmentof potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles", NUCLEIC ACIDS RESEARCH, vol. 31, no. 9, 1 January 2003 (2003-01-01), pages 2393 - 2400, XP002989074, ISSN: 0305-1048
LAN TAO ET AL: "Toll-like Receptor 7 Selective Synthetic Oligoribonucleotide Agonists: Synthesis and Structure-Activity Relationship Studies", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 21, November 2009 (2009-11-01), pages 6871 - 6879, XP002598928, ISSN: 0022-2623
Attorney, Agent or Firm:
ZUHN, Donald, L., Jr. (300 S. Wacker DriveSuite 310, Chicago IL, US)
Download PDF:
Previous Patent: AGONISTS AND ANTAGONISTS OF THE S1P5 RECEPTOR, AND METHODS OF USES THEREOF
Next Patent: CHEMICALLY PROGRAMMED VACCINATION
Next Patent: CHEMICALLY PROGRAMMED VACCINATION