Title:
SYSTEM FOR THE DIRECT PRODUCTION OF THERAPEUTIC YTTRIUM-90 FOR CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO/2020/036627
Kind Code:
A3
Abstract:
Systems and methods including a material that emits high energy beta particles to destroy cancer cells contained in cancerous tumor or tissue. Electronic neutron generators produce neutrons with energies that have a high probability to interact with the material yttrium-89 to produce yttrium-90. Yttrium-90 emits beta radiation with a maximum energy of about 2.25 MeV and a half-life of about 64 hours, which decays to stable zirconium. Stable yttrium-89 can be directly placed in or around cancerous tissue and irradiated with neutrons in the 0.1-15 KeV energy range to produce significant amounts of yttrium-90. The beta radiation emitted by yttrium-90 will primarily destroy the more radiation sensitive cancer cells within the range of the beta particles. The resulting zirconium isotope is not radioactive such that no further radiation is released. A low probability gamma is also created that will assist in cancer cell destruction.
Inventors:
HEIBEL MICHAEL D (US)
Application Number:
PCT/US2019/017793
Publication Date:
June 04, 2020
Filing Date:
February 13, 2019
Export Citation:
Assignee:
WESTINGHOUSE ELECTRIC CO LLC (US)
International Classes:
A61K41/00; A61N5/10
Foreign References:
| US20020133220A1 | 2002-09-19 | |||
| KR20060057527A | 2006-05-26 | |||
| US20020103410A1 | 2002-08-01 | |||
| US20010005930A1 | 2001-07-05 | |||
| EP1232771A1 | 2002-08-21 | |||
| US20140179978A1 | 2014-06-26 |
Other References:
SETH A. HOEDL; W. DEREK UPDEGRAFF: "The Production of Medical Isotopes without Nuclear Reactors or Uranium Enrichment", SCIENCE & GLOBAL SECURITY, vol. 23, no. 2, 31 March 2015 (2015-03-31), pages 121 - 153, XP009522410, ISSN: 0892-9882, DOI: 10.1080/08929882.2015.1037123
KALABUCHI, TATSUYA ET AL.: "Neutron capture cross section and capture gamma-ray spectra of Y89", EPJ WEB OF CONFERENCES 122, vol. 122, no. 05002, 2016, pages 1 - 4, XP055724293, DOI: 10.1051/epjconf/20161220 CNR*15 5002
KALABUCHI, TATSUYA ET AL.: "Neutron capture cross section and capture gamma-ray spectra of Y89", EPJ WEB OF CONFERENCES 122, vol. 122, no. 05002, 2016, pages 1 - 4, XP055724293, DOI: 10.1051/epjconf/20161220 CNR*15 5002
Attorney, Agent or Firm:
CAPRIOTTI, Roberto et al. (US)
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