DURING SURGERY

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present application claims priority to U.S. Provisional Patent Application No. 62/685,485, filed June 15, 2018, and U.S. Provisional Patent Application No. 62/695,244, filed July 9, 2018, the disclosures of which are incorporated by reference herein in their entireties.

BACKGROUND

[0002] Many conventional medical monitors require attachment of a sensor to a patient in order to detect physiologic signals from the patient and to transmit detected signals through a cable to the monitor. These monitors process the received signals and determine vital signs such as the patient's pulse rate, respiration rate, and arterial oxygen saturation. For example, a pulse oximeter is a finger sensor that may include two light emitters and a photodetector. The sensor emits light into the patient’s finger and transmits the detected light signal to a monitor. The monitor includes a processor that processes the signal, determines vital signs (e.g., pulse rate, respiration rate, arterial oxygen saturation), and displays the vital signs on a display.

[0003] Other monitoring systems include other types of monitors and sensors, such as electroencephalogram (EEG) sensors, blood pressure cuffs, temperature probes, air flow measurement devices (e.g., spirometer), and others. Some wireless, wearable sensors have been developed, such as wireless EEG patches and wireless pulse oximetry sensors.

[0004] Video-based monitoring is a field of patient monitoring that uses one or more remote video cameras to detect physical attributes of the patient. This type of monitoring may also be called “non-contact” monitoring in reference to the remote video sensor(s), which does/do not contact the patient. The remainder of this disclosure offers solutions and improvements in this field.

BRIEF DESCRIPTION OF THE DRAWINGS

[0005] FIG. 1 is a schematic view of a video-based patient monitoring system according to various embodiments described herein. [0006] FIG. 2 is a block diagram illustrating a video-based patient monitoring system having a computing device, a server, and one or more image capture devices according to various embodiments described herein.

[0007] FIG. 3 is a sequence of pulsation images generated from red, green, and blue (RGB) images captured using an image capture device of a video-based patient monitoring system according to various embodiments described herein.

[0008] FIG. 4 is a sequence of pulsation strength images generated from RGB images captured using an image capture device of a video-based patient monitoring system according to various embodiments described herein.

[0009] FIG. 5 is a flowchart of a method for generating and displaying a physiological strength field data across a field of view of an image capture device according to various embodiments described herein.

[0010] FIGS. 6A and 6B are schematic views of a region of interest (ROI) within a field of view of an image capture device according to various embodiments described herein.

[0011] FIG. 7 is a diagram illustrating whole field views and active views of an image capture device according to various embodiments described herein.

[0012] FIG. 8 is a flowchart of a method for determining low perfusion regions in a region of interest according to various embodiments described herein.

[0013] FIGS. 9A and 9B are schematic diagrams of a perfusion region of interest according to various embodiments described herein.

[0014] FIG. 10 is an image of patient region of interest injected with indocyanine green (ICG) dye and captured using an image capture device according to various embodiments described herein.

[0015] FIG. 11 is a flowchart of a method for obtaining and displaying pulsation and/or blood flow in a region of interest according to various embodiments described herein.

[0016] FIG. 12 is a schematic image of a region of interest illustrating pulsation contours plotted on top of an ICG image according to embodiments described herein.

[0017] FIG. 13 is a schematic image of a region of interest illustrating ICG contours plotted on top of an RGB-based pulsation image according to embodiments described herein. [0018] FIG. 14 is a table illustrating possible ICG and RGB information combinations and corresponding interpretations according to embodiments described herein.

DETAILED DESCRIPTION

[0019] The following disclosure describes video-based patient monitoring systems and associated methods for monitoring and/or assessing blood flow in a region of a patient during surgery. As described in greater detail below, systems and/or methods configured in accordance with embodiments of the present technology are configured to capture indocyanine green (ICG) images of a region of a patient to track ICG dye injected into the patient as an indication of blood flow in the region. Additionally, or alternatively, the systems and/or methods can be configured to capture RGB images of the region and/or to generate information pertaining to one or more parameters of blood flow in the region. In particular, the system and/or methods can be configured to generate an indication of pulsation, pulsation strength, and/or perfusion in the region as pixels in a sequence of RGB images change color. In these and other embodiments, the systems and/or methods can be configured to overlay the generated information onto the ICG images, for example, to provide a clinician a more complete indication of blood flow in the region.

[0020] ICG dye can be used to assess blood flow within a patient, such as to assess perfusion in a patient’s organ, or to assess the return of proper blood flow to a region after surgery. In some systems and methods, blood flow in a region of a patient can be monitored by injecting ICG dye into the patient and using a tuned infrared light source and an IR camera to visually track the ICG dye. In particular, ICG dye can be injected upstream from the region, and blood can transport the ICG dye to and/or through the region. The presence of ICG dye in a part of the region indicates that the part is receiving blood flow from the site at which the ICG dye was injected. In this manner, the systems and methods can use the ICG dye to identify possible occlusions within the region by identifying parts of the region where no ICG dye is present.

[0021] There are, however, several limitations to use of ICG dye as an indication of blood flow within a patient. For example, ICG dye has a relatively short half-life in humans (e.g., three to four minutes depending on metabolic rates), meaning that more than one dosage is often required. Yet ICG dye dosage limits apply for humans (typically one or two dosages per session depending on body weight). In addition, ICG dye trapped at a site within a patient where blood flow is cut off takes longer to metabolize. Thus, ICG dye injected as a second dosage may not provide a good indication that blood flow has ceased at the site if ICG dye from a first dosage is still present and visible. Moreover, ICG equipment is expensive, and the costs of the ICG equipment are often passed to patients requiring its use. These costs are often exacerbated as the patient requires multiple ICG dye injections and/or sessions.

[0022] Video-based patient monitoring systems and associated methods in accordance with embodiments of the present technology are configured to monitor one or more parameters of blood flow (e.g., pulsation, pulsation strength, perfusion, etc.) in a region of the patient. In some embodiments, the systems and methods are configured to use these parameters to indicate sites in the region where blood flow has decreased and/or ceased. For example, the systems and methods can be used prior to injection of ICG dye to indicate sites in the region where blood flow has decreased and/or ceased. The systems and methods can then be configured to interrogate these sites with ICG dye to further assess whether occlusions are present at the sites. This can reduce the number of ICG dye injections required as a clinician can use a first injection of ICG dye to interrogate a specific site rather than search for potential occlusion sites.

[0023] In these and other embodiments, the systems and methods can be employed after the injection of ICG dye to use the one or more parameters of blood flow to indicate sites in the region where blood flow has decreased and''or ceased. For example, the systems and methods can indicate whether blood flow has decreased and/or ceased at a site where ICG dye from a first injection is still present. This can decrease the likelihood that the presence of ICG dye at a site (such as a site with slowed metabolism of ICG dye) leads a clinician to incorrectly conclude that there is blood flow to the site. In turn, with the present systems and methods, subsequent injections of ICG dye can provide a better indication of blood flow to and/or within a region. Thus, the video-based patient monitoring systems and associated methods disclosed herein have the potential to improve recordkeeping, improve patient care, reduce errors in vital sign measurements, increase frequency and accuracy of blood flow monitoring, help healthcare providers better characterize and respond to adverse medical conditions indicated by a decrease and/or cessation in blood flow, and generally improve monitoring of patients, along with many other potential advantages discussed below.

[0024] Specific details of several embodiments of the present technology are described herein with reference to FIGS. 1-14. Although many of the embodiments are described with respect to devices, systems, and methods for video-based patient monitoring of a human during surgery, other applications and other embodiments in addition to those described herein are within the scope of the present technology. For example, at least some embodiments of the present technology may be useful for video-based patient monitoring of other animals and/or for video-based patient monitoring outside of surgery, such as pre-surgery and/or post-surgery. It should be noted that other embodiments in addition to those disclosed herein are within the scope of the present technology. Further, embodiments of the present technology can have different configurations, components, and-'or procedures than those shown or described herein. Moreover, a person of ordinary skill in the art will understand that embodiments of the present technology can have configurations, components, and/or procedures in addition to those shown or described herein and that these and other embodiments can be without several of the configurations, components, and/or procedures shown or described herein without deviating from the present technology.

[0025] FIG. 1 is a schematic view of a video-based patient monitoring system 100 and a patient 112 according to an embodiment of the invention. The system 100 includes a non-contact detector 110 placed remote from the patient 112. In some embodiments, the detector 110 can include one or more image capture devices, such as one or more video cameras. In the illustrated embodiment, the non-contact detector 110 includes a video camera 114 and a video camera 115. The cameras 1 14 and 115 are remote from the patient 112 in that they are spaced apart from and do not contact the patient 112. The cameras 114 and 115 each include a detector exposed to a field of view 116 and 117, respectively, that encompasses at least a portion of the patient 112.

[0026] The cameras 114 and 115 can capture a sequence of images over time. The cameras 114 and-'or 115 can be a standard or scientific red, green, and blue (RGB) camera capable of capturing images with a specified (e.g., 8, 12, 16, etc.) bit depth per pixel. As described in greater detail below, color variations in the pixels of images captured by the cameras 114 and/or 115 can be used to generate pulsation and/or perfusion information of a region of interest. The cameras 114 and/or 1 15 can additionally or alternatively be infrared cameras configured to detect (e.g., via use of a filter) infrared (IR) light projected from a tuned IR light source and/or reflected off the patient 112. As described in greater detail below, the IR light can illuminate indocyanine green (ICG) dye injected into the patient 112. The presence of and/or variations in the ICG dye in images captured by the cameras 114 and/or 115 can be used to determine characteristics of blood flow in a region of interest. Although the cameras 114 and 115 are illustrated as separate image capture devices, the cameras 114 and 115 can be combined into a single image capture device in other embodiments of the present technology.

[0027] The detected images can be sent to a computing device through a wired or wireless connection 120. The computing device can include a processor 1 18 (e.g., a microprocessor), a display 122, and/or hardware memory 126 for storing software and computer instructions. Sequential image frames of the patient are recorded by the video camera(s) 114 and ^/ or 115 and sent to the processor 1 18 for analysis. The display 122 may be remote from the camera(s) 114 and/or 115, such as a video screen positioned separately from the processor and memory. As described in greater detail below, the display 122 can be a display, such as a goggle headset, configured for augmented, virtual, and/or mixed reality. Other embodiments of the computing device may have different, fewer, or additional components than shown in FIG. 1. In some embodiments, the computing device may be a server. In other embodiments, the computing device of FIG. 1 may be additionally connected to a server (e.g., as shown in FIG. 2 and discussed in greater detail below). The captured images/video can be processed or analyzed at the computing device and/or a server to determine a variety of parameters (e.g., pulsation, pulsation strength, perfusion, etc.) of the patient 112, as disclosed herein.

[00281 FIG. 2 is a block diagram illustrating a video-based patient monitoring system 200 having a computing device 210, a server 225, and one or more image capture devices 285 according to various embodiments of the invention. In various embodiments, fewer, additional, and/or different components may be used in the system 200. The computing device 210 includes a processor 215 that is coupled to a memory 205. The processor 215 can store and recall data and applications in the memory 205, including applications that process information and send commands/signals according to any of the methods disclosed herein. The processor 215 may also (i) display objects, applications, data, etc. on an interface/display 207 and/or (ii) receive inputs through the interface/display 207. As shown, the processor 215 is also coupled to a transceiver 220.

[0029] The computing device 210 can communicate with other devices, such as the server 225 and/or the image capture device(s) 285 via (e.g., wired or wireless) connections 270 and/or 280, respectively. For example, the computing device 210 can send to the server 225 information determined about a patient from images captured by the image capture device(s) 285. The computing device 210 may be the computing device of FIG. 1. Accordingly, the computing device 210 may be located remotely from the image capture device(s) 285, or it may be local and close to the image capture device(s) 285 (e.g., in the same room). In various embodiments disclosed herein, the processor 215 of the computing device 210 may perform the steps disclosed herein. In other embodiments, the steps may be performed on a processor 235 of the server 225. In some embodiments, the various steps and methods disclosed herein may be performed by both of the processors 215 and 235. In some embodiments, certain steps may be performed by the processor 215 while others are performed by the processor 235. In some embodiments, information determined by the processor 215 may be sent to the server 225 for storage and/or further processing.

[0030] In some embodiments, the image capture device(s) 285 are remote sensing device(s), such as video camera(s) as described above with respect to FIG. 1. In some embodiments, the image capture device(s) 285 may be or include some other type(s) of device(s), such as proximity sensors or proximity sensor arrays, heat or infrared sensors/cameras, sound/acoustic or radiowave emitters/detectors, or other devices that include a field of view and may be used to monitor the location and/or characteristics of a patient or a region of interest (ROI) of a patient. Body imaging technology may also be utilized according to the methods disclosed herein. For example, backscatter x-ray or millimeter wave scanning technology may be utilized to scan a patient, which can be used to define and/or monitor a ROI. Advantageously, such technologies may be able to“see” through clothing, bedding, or other materials while giving an accurate representation of the patient’s skin. This may allow for more accurate measurements, particularly if the patient is wearing baggy clothing or is under bedding. The image capture device(s) 285 can be described as local because they are relatively close in proximity to a patient such that at least a part of a patient is within the field of view of the image capture deviee(s) 285. In some embodiments, the image capture deviee(s) 285 can be adjustable to ensure that the patient is captured in the field of view. For example, the image capture device(s) 285 may be physically movable, may have a changeable orientation (such as by rotating or panning), and/or may be capable of changing a focus, zoom, or other characteristic to allow die image capture device(s) 285 to adequately capture images of a patient and/or a ROI of the patient. In various embodiments, for example, the image capture device(s) 285 may focus on a ROI, zoom in on the ROI, center the ROI within a field of view by moving die image capture device(s) 285, or otherwise adjust the field(s) of view to allow for better and/or more accurate tracking/measurement of the ROI. [00311 The server 225 includes a processor 235 that is coupled to a memory 230. The processor

235 can store and recall data and applications in the memory 230. The processor 235 is also coupled to a transceiver 240. In some embodiments, the processor 235, and subsequently the server 225, can communicate with other devices, such as the computing device 210 through the connection 270.

[0032] The devices shown in the illustrative embodiment may be utilized in various ways. For example, any of the connections 270 and 280 may be varied. Any of the connections 270 and 280 may be a hard-wired connection. A hard-wired connection may involve connecting the devices through a universal serial bus (USB) port, serial port, parallel port, or other type of wired connection that can facilitate the transfer of data and information between a processor of a device and a second processor of a second device. In another embodiment, any of the connections 270 and 280 may be a dock where one device may plug into another device. In other embodiments, any of the connections 270 and 280 may be a wireless connection. These connections may take the form of any sort of wireless connection, including, but not limited to, Bluetooth connectivity, Wi-Fi connectivity, infrared, visible light, radio frequency (RF) signals, or other wireless protocols/methods. For example, other possible modes of wireless communication may include near-field communications, such as passive radio-frequency identification (RFID) and active RFID technologies. RFID and similar near-field communications may allow the various devices to communicate in short range when they are placed proximate to one another. In yet another embodiment, the various devices may connect through an internet (or other network) connection. That is, any of the connections 270 and 280 may represent several different computing devices and network components that allow the various devices to communicate through the internet, either through a hard-wired or wireless connection. Any of the connections 270 and 280 may also be a combination of several modes of connection.

[0033] The configuration of the devices in FIG. 2 is merely one physical system 200 on which the disclosed embodiments may be executed. Other configurations of the devices shown may exist to practice the disclosed embodiments. Further, configurations of additional or few'er devices than the ones shown in FIG. 2 may exist to practice the disclosed embodiments. Additionally, the devices shown in FIG. 2 may be combined to allow for fewer devices than shown or separated such that more than the three devices exist in a system. It will be appreciated that many various combinations of computing devices may execute the methods and systems disclosed herein. Examples of such computing devices may include other types of medical devices and sensors, infrared cameras/detectors, night vision cameras/detectors, other types of cameras, augmented reality goggles, virtual reality goggles, mixed reality goggle, radio frequency transmitters/receivers, smart phones, personal computers, servers, laptop computers, tablets, blackberries, RFID enabled devices, smart watch or wearables, or any combinations of such devices.

[0034] FIG. 3 is a sequence 310 of pulsation images 311-315 generated from RGB images captured using an image capture device (e.g., the RGB video camera 1 14 and/or 1 15 shown in FIG. 1 and/or an image capture device 285 shown in FIG. 2) of a video-based patient monitoring system. In particular, the sequence 310 of pulsation images 311-315 illustrates pulsation in a hand 308 of a patient (e.g., in real time) over a period of the patient’s heartbeat (e.g., over approximately 1 second). In some embodiments, the system can generate the pulsation images 311 -315 by directing the image capture device toward a region of the patient (e.g., the patient’s hand 308) and capturing a sequence of standard RGB images as a video-photoplethysmogram signal. The system can then calculate a pulsation field from subtle color changes in the pixels of the RGB images over time. For example, the system can compute a difference between a first color value of a pixel in a first RGB image and a second color value of the same pixel in a second RGB image. The system can assign the pixel a color from a predetermined color scheme corresponding to the computed difference (e.g., corresponding to the sign and/or magnitude of the difference). The assigned color can then be displayed over the respective RGB image to visually depict pulsation at that site in a pulsation image (e.g., in real time). In an embodiment, the assigned colors (from the predetermined color scheme) exaggerate or emphasize the subtle changes detected by the system, to make the detected changes easier to see visually in real time.

[0035] As shown in FIG. 3, the backgrounds of the pulsation images 311-315 (i.e., the nonskin regions) are black because the corresponding pixels in the RGB images do not change color from one RGB image to the next and have been excluded with an image mask. The hand 308 varies in color across the field of view of the image capture device and across the sequence 310 of pulsation images 311-315. This variation in color indicates the pulsation information captured by and generated from color changes in the corresponding pixels of the RGB images. Thus, by assigning colors from a predetermined color scheme to the subtle color changes in the RGB images, the system can depict pulsation information of the hand 308 to a clinician in the pulsation images 311-315. [0036] In some embodiments, the generated pulsation images (e.g., the images 311-315) and/or the corresponding RGB images can be used to determine the patient’s heart rate. For example, the pulsation image 311 is generally identical to the pulsation image 315, indicating that the patient’s heart was in a similar phase (e.g., a diastole phase or a systole phase) at the time the standard RGB images underlaying the pulsation images 311 and 315 were captured. Using the time elapsed between the two RGB images, the system can calculate a period of the patient’s heartbeat and, in turn, the patient’s heart rate. In these and other embodiments, the system can use a second signal of different colors in combination with the generated pulsation information to calculate oxygen saturation in the region of the patient. For example, two signals from the RGB camera (or multiple signals from any combination of monochrome cameras and filters) may be used to provide an indication of oxygen saturation using the standard ratio-of-ratio technique used in pulse oximetry (as described in more detail in co-pending Application Serial No. 15/432,057).

[0037] In some embodiments, the video-based patient monitoring system can be configured to generate an indication of the strength of one or more physiological parameters within the field of view of the image capture device. For example, FIG. 4 is a sequence 420 of pulsation strength images 425- 427 generated from RGB images captured using an image capture device (e.g., the camera 114 and/or 115 shown in FIG. 1 and/or the image capture device 285 shown in FIG. 2) of the video-based patient monitoring system. In particular, the sequence 420 of the pulsation strength images 425-427 illustrates reperfusion in a hand 408 of a patient over approximately 40 seconds. In some embodiments, the system can generate tire pulsation strength images 425-427 by directing the image capture device toward a region of the patient (e.g., the patient’s hand 408), capturing a sequence of standard RGB images as a video-photoplethysmogram signal, generating pulsation information in accordance with the discussion above, and averaging the pulsation information (e.g., the amplitudes and/or other measures of strength of the pulsation signals) over multiple RGB images and/or multiple heart beats.

[0038] The pulsation strength image 425, for example, corresponds to an RGB image captured when blood flow to the hand 408 of the patient is cut off (e.g., via a blood pressure cuff). As shown, little to no pulsation strength information is available in the pulsation strength image 425 because little to no underlying pulsation information is available (as there is little to no blood flow to the hand 408). As a result, the hand 408 is indistinguishable from the background of the pulsation strength image 425, and the colors depicted in the pulsation strength image 425 can largely be attributable to noise detected from the environment.

[0039] A pulsation strength image similar to the pulsation strength image 425 can also be generated when not enough underlying pulsation information is available. For example, a similar pulsation strength image can be generated when this feature of the video-based patient monitoring system is first activated, when a region of the patient visible in the field of view of the image capture device changes position within the field of view, and/or when the image capture device is moved.

[0040] In contrast, as blood begins to flow into the hand 408 and/or as underlying pulsation information becomes available, the system can generate pulsation strength information by averaging the pulsation information over multiple images and/or heart beats. For example, the hand 408 in the pulsation strength images 426 and 427 becomes distinguishable from the backgrounds of the pulsation strength images 426 and 427 as blood flow is restored to the hand 408 and as an increasing amount of underlying pulsation information becomes available. In this manner, the video-based patient monitoring system can depict pulsation strength information of the hand 408 to a clinician in the pulsation strength images 425-427. Although the sequence 420 of images illustrated in FIG. 4 depicts pulsation strength across the field of view of the image capture device, the video-based patient monitoring system can be configured to generate an indication of the strength of one or more other physiological parameters (e.g., perfusion index, oxygen saturation, respiratory rate, heart rate, etc.) in addition to or in lieu of pulsation strength.

[0041] Fig. 5 is a flowchart of a method 530 for generating and displaying a physiological strength field across a field of view of an image capture according to various embodiments described herein. All or a subset of the steps of the method 530 can be executed by various components of a video-based patient monitoring system and/or an operator of the system (e.g., a clinician). For example, all or a subset of the steps of the method 530 can be executed by (i) components of the video-based patient monitoring system 100 shown in FIG. 1 and/or (ii) components of the video- based patient monitoring system 200 shown in FIG. 2.

[0042] The method 530 can begin at block 531 by activating the physiological strength field feature. In some embodiments, the method 530 can activate the physiological strength field feature via a set feature option of the video-based patient monitoring system. For example, a clinician can enable the physiological strength field feature by (i) actuating a hardware button or switch on the system, (ii) pressing a corresponding software button option (e.g., on a touchscreen display of the system), and/or (iii) otherwise instructing (e.g., via voice command) the system to enable the physiological strength field feature. In these and other embodiments, the method 530 can automatically activate the physiological strength field feature. For example, the method 530 can activate the physiological strength field feature (i) when the system is powered on and/or (ii) when the mage capture device or a region of the patient within the field of view of the image capture device is stationary (e.g., for a predetermined amount of time).

[0043] At block 532, the method 530 can lock the position of the image capture device. In some embodiments, the method 530 can lock the position of the image capture device when the method 530 enables the physiological strength field feature (at block 531). In these and other embodiments, the method 530 can lock the position of the image capture device after the physiological strength field feature is enabled and in response to instructions received from the clinician (e.g., via a voice command or other action) and/or the system.

[0044] FIG. 6A is a schematic view of an example ROI 640 within a field of view 650 of an image capture device of the video-based patient monitoring system. Using the embedment illustrated in FIG. 6A as an example, the method 530 (FIG. 5), in some embodiments, can be configured to lock the image capture device in position to hold the ROI 640 stationary within the field of view 650 for a predetermined amount of time (e.g., 10 seconds). For example, the predetermined amount of time can be a period of time sufficient to acquire enough spatial information of one or more physiological parameters of the ROI 640 to generate a robust aggregated physiological strength field view, as discussed in greater detail below with respect to block 533-535 of the method 530. In these and other embodiments, the method 530 can be configured to lock the image capture device in position to hold the ROI 640 within the field of view 650 until a certain number of events have occurred. For example, the method 530 can be configured to lock the image capture device in position until the method 530 determines a certain number of cardiac pulses (e.g., 10 cardiac pulses) and/or a certain number of respiratory cycles (e.g., 3-5 respiratory cycles) have occurred. In these and still other embodiments, the method 530 can lock the image capture device in position for another amount of time (e.g., an amount of time defined within a voice command or other input received from the clinician, an amount of time corresponding to a particular surgical operation, an amount of time corresponding to a particular region of interest, etc.). In some embodiments, the video-based patient monitoring system and/or the image capture device(s) can include an on-board stabilization element that is configured to keep the cameras (e.g., the cameras 114 and/or 115) of the patient monitoring system and/or the image capture device(s) still spatially.

[0045] At block 533, the method 530 can acquire physiological information over a period of time. Examples of physiological parameters that the method 530 can acquire include pulsation, perfusion index, oxygen saturation, respiratory rate, and/or heart rate, among others (as described in more detail in co-pending Application Serial Nos. 15/432,057 and 15/432,063). In some embodiments, the method can acquire physiological information over a period of time equivalent to the amount of time the method 530 locks the position of the image capture device (at block 532). In these and other embodiments, the method can acquire physiological information over a period of time greater or lesser than the amount of time the method 530 locks the position of the image capture device. For example, if the position of the image capture device remains unchanged after the method 530 locks the position of the image capture device for an amount of time (at block 532), the method 530 can continue to acquire physiological information (e.g., until the position of the image capture device is changed). In a preferred embodiment, the method 530 can acquire physiological information over a period of time sufficient to acquire enough spatial information of one or more physiological parameters of the ROI 640 (FIG. 6A) to generate a robust aggregated physiological strength field view, as described in greater detail below with respect to blocks 534-535 of the method 530.

[0046] In some embodiments, the method 530 can acquire physiological information across all or a subset of the field of view 650 (FIG. 6A) of the image capture device. For example, FIG. 7 is a diagram illustrating a whole field of view 760 of an image capture device at different locations A’ and B’ and an active field of view 770 of an image capture device at different locations A and B according to various embodiments described herein. The field of view 650 (FIG. 6A) in some embodiments can be a whole field of view equivalent to the whole field of view 760 shown in FIG. 7. In these embodiments, the method 530 can be configured to acquire physiological information across the entirety of the whole field of view 650 and/or 760. In these and other embodiments, the method 530 can be configured to acquire physiological information across a subset of the whole field of view 650 and/or 760. For example, the method 530 can be configured to acquire physiological information across only the active field of view 770 shown within the whole field of view 760 in FIG. 7. In some embodiments, the active field of view 770 can correspond to a subset of the whole field of view 760 and/or can correspond with a region of interest (e.g., ROI 640 shown in FIG. 6A) of a patient. In these and other embodiments, the method 530 can define the active field of view 770 within the whole field of view 650 and/or 760. For example, a clinician can define the active field of view 770 as an input into the system. Additionally, or alternatively, the video-based patient monitoring system can define the active field of view 770 (e.g., by setting the active field of view 770 equivalent to an ROI 640 (FIG. 6A) identified within the whole fields of view 650 and/or 760). Although the active field of view 770 is illustrated having a generally rectangular shape, the active field of view 770 in other embodiments can have a different shape (e.g., the shape of the identified ROI 640).

[0047] At block 534, the method 530 can calculate a physiological strength field of one or more physiological parameters of the ROI 640 (FIG. 6A). In some embodiments, the method 530 can calculate a physiological strength field of one or more physiological parameters in accordance with the discussion above with respect to FIGS. 3 and 4. Using pulsation as an example, the method 530 can generate pulsation information pertaining to the ROI 640 from a video-photoplethysmogram signal (e.g., by computing subtle color changes in pixels of RGB images) acquired by the method 530 of the ROI 640 at block 533. This can provide an indication of each pulsation at each site in the ROI 640 in real time. The method 530 can then average the pulsation information (e.g., the amplitudes and/or other measures of strength of the pulsation signals) across multiple RGB images and/or across multiple events (e.g., cardiac pulses, respiratory cycles, etc.) in order to produce a robust estimate of the pulsation strength across the ROI 640. This can provide an indication of perfusion to each site in the ROI 640 over a period of time rather than an instantaneous indication of pulsation at each site, which in turn can help to identify sites within the ROI 640 where blood flow is weak and/or nonexistent.

[0048] In some embodiments, the method 530 can calculate a physiological strength field across only the active field of view 650 and/or 770 (FIGS. 6A and 7). In other embodiments, the method 530 can calculate a physiological strength field across a subset of the whole field of view 650 and/or 760 shown in FIGS. 6A and 7 (e.g., a subset corresponding to an identified ROI 640 within the whole fields of view 650 and/or 760). In still other embodiments, the methods 530 can calculate a physiological strength field across the entirety of the whole field of view 650 and/or 760.

[0049] At block 535, the method 530 can display the physiological strength field. In some embodiments, the method 530 can superimpose the physiological strength field on the image of the ROI 640 within the field of view 650 of the image capture device. For example, FIG. 6B is a schematic view of the ROI 640 within the field of view 650 shown in FIG. 6A having a physiological strength field 654 superimposed onto the original image (e.g., onto the entirety of the field of view 650 and/or onto only the ROI 640). In these and other embodiments, the method 530 can (e.g., temporarily) replace the image of the ROI 640 within the field of view 650 of the image capture device with a generated physiological strength field image. The physiological strength field 654 can be colored and/or shaded according to the strength or value of the physiological field.

[0050] In some embodiments, the method 530 can be configured to display to a clinician all or a subset of the calculated physiological strength field across the whole field of view 650 and/or 760 and/or across the active field of view 650 and/or 770. In these embodiments, the whole field of view 650 and/or 760 can correspond to an entire area visible to the image capture device and/or the active field of views 650 and/or 770 can correspond to a subset of the entire area that is displayed to a clinician. For example, in embodiments where the field of view 650 (FIGS. 6A and 6B) is equivalent to the whole field of view 760 (FIG. 7) and the method 530 calculates a physiological strength field across the entirety of the whole field of view 760 (at block 534), the method 530 can be configured to display to the clinician only the portion(s) of the calculated physiological strength field corresponding to the active field of view 770. This allows the method 530 to instantly and/or automatically display the physiological strength field within the active field of view 770 when a clinician moves the image capture device (and thereby moves the whole field of view 760 and the active field of view 770) to a new position without first having to wait for the method 530 to calculate the physiological strength field (at blocks 531-534) at the new location.

[0051] Using the embodiment illustrated in FIG. 7 as an example, the method 530 can acquire physiological information (at block 533) and can calculate a physiological strength field (at block 534) across a whole field of view 760 of an image capture device while the whole field of view 760 is at location A’. Although the method 530 has acquired physiological information and calculated the physiological strength field across the entire whole field of view 760, the method 530 can display only a portion of the physiological information and/or of the physiological strength field that corresponds to the active field of view 770 at location A (e.g., only the portion of the physiological information and/or of the physiological strength field at the center of the whole field of view 760 at location A’). Because the method 530 has acquired physiological information and/or has calculated a physiological strength field across the entirety of the whole field of view 760, the method 530 can instantly and/or automatically display a portion of the physiological information and/or of the physiological strength field at different locations within the whole field of view 760 when the image capture device is moved (e.g., shifted, changed, etc.). For example, a clinician can subsequently move the image capture device such that the active field of view 770 shifts (e.g., moves, changes, etc.) from location A to location B. Because the active field of view at location B is still within the whole field of view 760 at location A’ (i.e., because the method 530 has already acquired physiological information and/or has already calculated a physiological strength field at location B), the method 530 can instantly and/or automatically display the portion of the physiological information and/or of the physiological strength field corresponding to the active field of view 770 at location B. As a result, the method 530 (e.g., the clinician) is not required to wait for the method 530 to acquire the physiological information and/or to calculate the physiological strength field at this new location B before the method 530 can display the physiological information and/or the physiological strength field at this new location B,

[0052] In some embodiments, when the image capture device and/or the active field of view 770 is shifted (e.g., moved, changed, etc.), the method 530 can be configured to (e.g., automatically and/or in response to received instructions) shift (e.g., change, move, etc.) the whole field of view 760. For example, when the image capture device is shifted such that the active field of view 770 is shifted from location A to location B, the method 530 can be configured to shift the whole field of view 760 from location A’ to location B’. In these embodiments, the method 530 can be configured to (e,g., automatically and/or in response to received instructions) acquire physiological information and/or to calculate a physiological strength field across the whole field of view 760 at the new location B’. Thus, when a clinician subsequently shifts the image capture device such that the active field of view 770 is shifted to a new location within the whole field of view 760 at location B’, the method 530 can instantly and/or automatically display an updated portion of the physiological information and/or of the physiological strength field corresponding to the active field of view 770 at the new location. Although the active field of view 770 is illustrated at the center of the whole field of view 760, the active field of view 770 in other embodiments can be positioned at other locations within the whole field of view 760 of the image capture device. [0053| As discussed above, a clinician display in some embodiments can be virtual, augmented, and/or mixed reality goggles. In these embodiments, the active field of view 770 can be a portion of the whole field of view 760 displayed on the goggles. Thus, as a clinician moves and the position and/or orientation of the goggles changes, the method 530 can instantly and/or automatically display physiological information and/or physiological strength information corresponding to the active field of view 770 at the new position.

[0054] In this manner, the method 530 can provide a robust estimate of the physiological strength field across an ROI 640 even despite the frequently changing location of the fields of view 650 of the image capture device during surgery. As a result, a clinician can quickly identify potential problem sites 647 (FIG. 6B) in the ROI 640 from the visual indication of the physiological strength field across the ROI 640. For example, the problem site 647 shown in FIG. 6B within the ROI 640 can represent a region of low perfusion if the depicted physiological strength field were a perfusion index strength field. Alternatively, the problem site 647 within the ROI 640 can represent a region of hypoxia if the depicted physiological strength field were an oxygen saturation strength field.

[0055] Although the steps of the method 530 are discussed and illustrated in a particular order, the method 530 in FIG. 5 is not so limited. In other embodiments, the method 530 can be performed in a different order. In these and other embodiments, any of the steps of the method 530 can be performed before, during, and/or after any of the other steps of the method 530. Moreover, a person of ordinary skill in the relevant art will readily recognize that the illustrated method can be altered and still remain within these and other embodiments of the present technology. For example, one or more steps of the method 530 illustrated in FIG. 5 can be omitted and/or repeated in some embodiments.

[0056] As discussed above, video-based patient monitoring systems configured in accordance with various embodiments of the present technology can be configured to indicate and/or identify potential problem sites within a region of interest monitored by an image capture device of the systems. For example, in some embodiments, the systems can be configured to indicate and/or identify regions of poor perfusion that may be susceptible to hypoxia. In particular, the systems can monitor a region of interest before and after blood supply is cut off from (or returned to) the region of interest. Cutting off or returning blood supply to a region should result in a noticeable change in light intensity and/or color in the region, such as disappearance or reappearance of pulsatile changes in light and/or color. Parts of the region of interest that do not markedly change in light intensity and/or color may be identified as abnormally low perfusion regions.

|0057] FIG. 8 is a flowchart of a method 880 for determining low perfusion regions in a region of interest according to various embodiments described herein. All or a subset of the steps of the method 880 can be executed by various components of a video-based patient monitoring system and/or an operator of the system (e.g., a clinician). For example, all or a subset of the steps of the method 880 can be executed by (i) components of the video-based patient monitoring system 100 shown in FIG. 1 and/or (ii) components of the video-based patient monitoring system 200 shown in FIG. 2.

|0058] FIG. 9A is a schematic diagram of a perfusion ROI 990. Using the embodiment illustrated in FIG. 9A as an example, the method 880 illustrated in FIG. 8 can begin at block 881 to calibrate the video-based patient monitoring system. In some embodiments, the method 880 can calibrate the video-based patient monitoring system using a pulse oximeter 980 (FIG. 9A). In particular, the method 880 can attach the pulse oximeter 980 to the ROI 990 and can take a point measure of the ROI 990 using the pulse oximeter 980 to calculate a perfusion index that can be used to calibrate the video-based patient monitoring system to the ROI 990 (e.g., across the whole and/or active field of view of the image capture device). Calibrating the video-based patient monitoring system to the ROI 990 can allow the method 880 to calculate an absolute value of perfusion and/or another measure of perfusion at the surface of the ROI 990, as described in greater detail below with respect to blocks 884 and 885 of the method 880. In some embodiments, the method 880 can proceed to block 882 after calibrating the video-based patient monitoring system.

[0059] Alternatively, the method 880 in some embodiments can begin at block 882. For example, the method 880 can begin at block 882 if the method 880 has previously calibrated the video-based patient monitoring system to the ROI 990 (e.g., in a previous iteration of the method 880). In other embodiments, the method 880 can begin at block 882 without calibrating the video- based patient monitoring system. For example, the method 880 in some embodiments can calculate a relative change in light intensity and/or color at the surface of the ROI 990, as described in greater detail below with respect to block 884-885 of the method 880, regardless of whether the video-based patient monitoring system has been calibrated to the ROI 990. [0060] At block 882, the method 880 can capture a video sequence of the ROI 990 before blood flow to the region is cut off (this can be referred to as a pre-cut off video sequence). In some embodiments, the method 880 can capture a pre-cut off sequence of RGB images of the ROI 990 in accordance with the discussion above with respect to FIGS. 3-7. For example, tile method 880 can capture a pre-cut off sequence of RGB images as a video-photoplethysmogram signal using an RGB camera (e.g., the RGB camera 1 14 shown in FIG. 1) of the video-based patient monitoring system.

[0061] At block 883, the method 880 can cut off blood supply to the ROl 990. In some embodiments, the method 880 can cut off blood supply to the ROI 990 automatically after capturing a pre-cut off video sequence of the ROI 990 at block 882. In other embodiments, the method 880 can wait to cut off blood supply to the ROI 990 until instructed to do so (e.g., via a voice command and/or an input into the video-based patient monitoring system).

[0062] ln some embodiments, the method 880 can cut off blood supply to the ROI 990 using a blood pressure cuff, one or more tourniquets, and/or by pressing on the ROI 990 (e.g., the skin at the ROI 990). For example, a clinician can manually cut off blood supply to the ROI 990 using the blood pressure cuff, the one or more tourniquets, and/or by pressing on (e.g., squeezing) the ROI 990. In these embodiments, the clinician can inform the video-based patient monitoring system whether blood supply has been cut off to the ROI 990. In these and other embodiments, the blood pressure cuff can be coupled to the image capture device of the video-based patient monitoring system. In these embodiments, the before and after blood supply cut-off periods can be determined automatically. For example, the method 880 can instruct the blood pressure cuff to cut off blood supply to the ROI 990. Because the blood pressure cuff is coupled to the image capture device of the video-based patient monitoring system, the image capture device can be aware of when blood supply is cut off to (lie ROI 990 and/or can automatically begin capturing pre- and/or post-cut off video sequences of the ROI 990 (at blocks 882 and/or 884).

[0063] At block 884, the method 880 can capture a post-cut off video sequence of the ROI 990 after the mechanism to cut off blood supply is discontinued. In some embodiments, the method 880 can capture a post-cut off sequence of RGB images of the ROI 990 in accordance with the discussion above with respect to FIGS. 3-7. For example, the method 880 can capture a post-cut off sequence of RGB images using an RGB camera (e.g., the RGB camera 1 14 shown in FIG. 1) of the video-based patient monitoring system as a video-photoplethysmogram signal. [0064] At block 885, the method 880 can compare the pre-cut off video sequence to the postcut off video sequence. In some embodiments, the method 880 can compare the relative change in pixel intensities (e.g., light intensity) and/or color between the pixels in the pre-cut off video sequence and the corresponding pixels in the post-cut off video sequence. In these and other embodiments, the method 880 can compare the absolute values of perfusion index and other measure of perfusion between the pixels in the pre-cut off video sequence and the corresponding pixels in the post-cut off video sequence. For example, the method 880 can compare pixel intensities and/or colors in one RGB image of the pre-cut off video sequence to the pixel intensities and/or colors in (e.g., a corresponding) one of the RGB images of the post-cut off video sequence. In these and other embodiments, the method 880 can compare average pixel intensities and/or colors in the pre-cut off video sequence to corresponding average pixel intensities and/or colors in the post-cut off video sequence.

[0065] As discussed above, parts of the ROI 990 that do not markedly change in light intensity and/or color may be identified to a clinician as abnormally low perfusion regions because cutting off blood supply to the ROI 990 should result in a significant change in the video-perfusion measure of all parts of the ROI 990. Thus, at block 886, the method 880 can determine whether a threshold number (e.g., two or more) of adjacent pixels in parts of the ROI 990 maintain light intensity and/or color levels within a specified range (e.g., 1%, 2%, 5%, 10%, etc.) between the pre-cut off video sequence and the post-cut off video sequence. For example, the method 880 can determine a part of the ROI 990 is an abnormally low perfusion region if adjacent pixels in that region maintain light intensity and/or color levels within a specified range of light intensity and/or color levels in the precut off and post-cut off video sequences. The specified range of light intensity and/or color levels can be tailored to an individual patient and/or surgical procedure (e.g., to different skin colors, to different organ colors, etc.). If the method 880 determines that a total number of adjacent pixels in a part of the ROI 990 greater than the threshold number maintained light intensity and/or color levels within the specified range between the pre-cut off video sequence and the post-cut off video sequence, the method 880 can proceed to block 887 to indicate the part as a region of concern. Otherwise, the method 880 can proceed to block 888 to not indicate the part as a region of concern.

[0066] In these and other embodiments, the method 880 can determine that a part of the ROI 990 is an abnormally low perfusion region if a gradient change in light intensity and/or color level is sufficiently different in one group of pixels compared to another group of pixels. For example, if the method 880 determines that a gradient change in light intensities and/or color levels across adjacent pixels in a first group of pixels differs from the gradient change in a second group of pixels by more than a specified threshold value (e.g., 50%), this can indicate that one of those two groups of pixels is changing while the other is not. For example, if the gradient in the first group of pixels is high, and the gradient in the second is low, this can identify the first group of pixels as a well-perfused region (losing perfusion when the blood supply is cut off) and the second group of pixels as a poorly perfused region (not experiencing a change when the blood supply is cut off). The specified threshold value can be tailored to an individual patient and/or procedure (e.g., to different skin colors, to different organ colors, etc,). If the method 880 determines that the gradient change in light intensity and/or color level is greater than the specified threshold, the method 880 can proceed to block 887 to indicate a corresponding group of adjacent pixels as a region of concern. Otherwise, the method 880 can proceed to block 888 to not indicate the part as a region of concern.

[0067] FIG. 9B is a schematic diagram of a region of concern 995 within the perfusion ROI 990 shown in FIG. 9 A. In some embodiments, the region of concern 995 can correspond to a part of the ROI 990 exhibiting signs of abnormally low perfusion. Using the embodiment illustrated in FIG. 9B as an example, the method 880 can indicate a region of concern 995 on a displayed video image at block 887. In some embodiments, the method 880 can indicate the region of concern 995 by highlighting the corresponding part of the ROI 990 on the video image (e.g., displayed to a clinician). In these and other embodiments, the method 880 can indicate the region of concern 995 by activating an audio and/or visual alarm to, for example, alert a clinician of the region of concern 995. Although the region of concern 995 corresponds to only a part of the ROI 990 in the embodiment illustrated in FIG. 9B, the method 880 in other embodiments can indicate the entire ROI 990 as a region of concern.

[0068] At block 888, the method 880 does not indicate a region of concern within the ROI 990. For example, the method 880 does not indicate a region of concern within the ROI 990 where the method 880 (at block 886) has determined there is not a number of adjacent pixels (that maintained light intensities and/or color levels within the specified range between the pre-cut off video sequence and the post-cut off video sequence) greater than the threshold number.

[0069] In some embodiments, several iterations of the method 880 can be executed. For example, several iterations of the method 880 can be executed to determine and/or monitor the progress of the ROT 990 and/or of a region of concern over time (e.g., during the progression of a disease state, during reperfusion of a ROI, and/or during recovery). In these and other embodiments, the method 880 can be configured to activate an audio and/or visual alann if a deterioration is detected. For example, if the perfusion index within the ROI 990 and/or within the region of concern 995 falls below a specified threshold, such as 50 percent reduction in the perfusion index compared to the normal state or a known acceptable norm, the method 880 can activate the audio and/or visual alarm. In some embodiments, a threshold value may be used in addition to or in lieu of a relative percentage reduction. For example, an alarm may sound if the perfusion index falls below 1%, 0.1%, 0.01%, etc. The threshold value can be dependent on an individual patient and/or his/her health status. For example, a patient may have low perfusion issues, and the normal range of perfusion index may not be applicable to them. As such, the relative percentage reduction and/or the threshold value can be specified and/or tailored to a specific patient. Therefore, all or a subset of the steps of the method 880 can be useful in an operating room, an intensive care unit, within a home environment, and/or in a number of use cases (e.g., reperfusion, hypoxia, deteriorating patient conditions, etc.).

[0070] Although the steps of the method 880 are discussed and illustrated in a particular order, the method 880 in FIG. 8 is not so limited. In other embodiments, the method 880 can be performed in a different order. For example, the order of block 882-884 of the method 880 can be reversed in some embodiments. In these and other embodiments, any of the steps of the method 880 can be performed before, during, and/or after any of the other steps of the method 880. Moreover, a person of ordinary skill in the relevant art will readily recognize that the illustrated method can be altered and still remain within these and other embodiments of the present technology. For example, one or more steps of the method 880 illustrated in FIG, 8 can be omitted and/or repeated in some embodiments.

[0071] FIG. 10 is an image 1000 of ROl 1007 (e.g., an organ) injected with ICG dye 1005 and captured using an image capture device of a video-based patient monitoring system according to various embodiments described herein. For example, the image 1000 can be captured by (i) the cameras 114 and/or 115 of the video-based patient monitoring system 100 illustrated in FIG. 1 and/or (ii) by the image capture device(s) 285 of the video-based patient monitoring system 200 illustrated in FIG, 2. The ROI 1007 illustrated in the image 1000 is a colon within a patient. As discussed above, blood flow in the ROI 1007 can be monitored by injecting the ICG dye 1005 into the patient and using a tuned infrared light source and an IR camera (or an RGB camera with an IR filter) to visually track tlie ICG dye 1005. In particular, the ICG dye 1005 can be injected upstream from the ROI 1007, and blood can transport the ICG dye 1005 to and/or through ROI 1007.

[0072] As shown in FIG. 10, the part of the ROI 1007 illustrated in the left half of the image 1000 is illuminated with the ICG dye 1005. Presence of the ICG dye 1005 in this part of the ROI 1007 indicates that the part is receiving blood flow from the site at which the ICG dye 1005 was injected (e.g., via an IV or a syringe). In contrast, the part of the ROI 1007 illustrated in the right half of the image 1000 is not illuminated with the ICG dye 1005. The lack of ICG dye 1005 in this part of the ROI 1007 indicates that there is less perfusion, which may indicate an occlusion 1008 between the part of the ROI 1007 on the left and the part of the ROI 1007 on the right that is inhibiting and/or preventing blood flow into the part of the ROI 1007 on the right from the part of the ROI 1007 on the left. In this manner, the video-based patient monitoring system can use the ICG dye 1005 to identify potential sites (e.g., of occlusions 1008) where blood flow has decreased and/or ceased within the ROI 1007 by identifying parts of the ROI 1007 where none of the ICG dye 1005 is present.

[0073] As discussed above, there are, however, several limitations to use of the ICG dye 1005 as the sole indication of blood flow within an ROI 1007. Thus, systems, device, and/or methods configured in accordance with embodiments of the present technology are configured to combine RGB-derived pulsation information with ICG-derived information to overcome one or more of the shortcomings outlined above (among others), as described in greater detail below.

[0074] FIG. 11 is a flowchart of a method 1110 for obtaining and displaying pulsation and/or blood flow in a region of interest according to various embodiments described herein. All or a subset of the steps of the method 1110 can be executed by various components of a video-based patient monitoring system and/or an operator of the system (e.g., a clinician). For example, all or a subset of the steps of the method 1110 can be executed by (i) components of the video-based patient monitoring system 100 shown in FIG. 1 and/or (ii) components of the video-based patient monitoring system 200 shown in FIG. 2.

[0075] The method 1110 can begin at blocks 1111 and 1112 to capture an RGB video sequence of a region of interest (ROI) to produce an RGB view. In some embodiments, the method 1110 can capture an RGB video sequence using a non-contact detector, such as an image capture device and/or video camera (e.g., the video camera(s) 114 and/or 115 of the non-contact detector 110 shown in FIG. 1 and/or the image capture device(s) 285 shown in FIG. 2). For example, the method 1110 can capture an RGB video sequence of the ROI using a standard or scientific RGB camera.

[0076] At blocks 1113 and 1114, the method 1110 can capture an ICG video sequence of the ROI to produce an ICG view. In some embodiments, the method 1110 can capture an ICG video sequence using a non-contact detector, such as an image capture device and/or video camera (e.g., the video camera(s) 1 14 and/or 1 15 of the non-contact detector 1 10 shown in FIG. 1 and/or the image capture device(s) 285 shown in FIG. 2). For example, the method 1110 can capture an ICG video sequence of the ROI using a tuned IR light source and a video camera with an IR filter or using other, more sophisticated lighting methods, such as sequential lighting and background subtraction.

[0077] At blocks 1115 and 1116, the method 1110 can compute a pulsation field and/or a pulsation strength field to produce a pulsation field view. In some embodiments, the method 1 1 10 can compute a pulsation field across the field of view of the RGB video sequence in accordance with the discussion above with respect to FIG, 3. For example, the method 1110 can compute a pulsation field from the subtle color changes and/or changes in light intensities in pixels of RGB images in the RGB video sequence to provide an indication of the state of perfusion within the ROI. In these and other embodiments, the method 1110 can compute the pulsation field in real time. In these and still other embodiments, the method 1110 can compute a pulsation strength field across the field of view of the RGB video sequence in accordance with the discussion above with respect to FIGS. 4-7. For example, the method 1110 can compute a pulsation strength field by averaging the (e.g., amplitudes) of the subtle color changes over several RGB images in the RGB video sequence and ^/ or over a period of time to provide an indication of perfusion (perfusion index) within the ROI. In these and still other embodiments, the method 1110 can compute a pulsation field and-'or a pulsation strength field using an ICG fluorescent region of the ICG view as a mask to perform the pulsation field and/or pulsation strength field calculations. In this manner, the pulsation signal quality can be improved by removing background noise from the overall computation.

(0078] At blocks 1 1 17 and 1 1 18, the method 11 10 can compute a standard ICG overlay. In some embodiments, the method 1110 can compute a standard ICG overlay by superimposing the RGB video sequence onto the ICG video sequence. In these and other embodiments, the method 1110 can compute a standard ICG overlay by superimposing the ICG video sequence onto the RGB video sequence. As discussed above, the standard ICG overlay can provide an indication of the parts of a ROI that are receiving blood flow and/or an indication of potential poorly perfused sites within the ROI where blood flow has decreased and/or ceased. The poorly perfused sites may be due to an occlusion or significant vasoconstriction.

[0079] At blocks 1119 and 1120, the method 1110 can compute an enhanced ICG overlay. In some embodiments, the method 1110 can compute an enhanced ICG overlay by superimposing and/or blending the pulsation field computed at blocks 1115 and 1 1 16 with the ICG view. This can provide an indication of pulsatile flow within the ROI. In this manner, if blood flow decreases and/or ceases at a site within the ROI, the enhanced ICG overlay can indicate that pulsations have decreased and/or ceased at the site even though ICG dye is still present at the site. The blending method used to combine ICG overlay and pulsation field overlay can be optimized to make these clinical regions visibly highlighted such as by exaggerating the color changes on the graphical screen to the user.

[0080] In these and other embodiments, the method 1110 can compute an enhanced ICG overlay by superimposing the pulsation strength field computed at blocks 1115 and 1116 onto the ICG video sequence. In some embodiments, the method 1110 can quantify the state of perfusion within an ROI using the enhanced ICG overlay. For example, in embodiments where (i) blood flow has been cut off to a ROI using a clamp and (ii) ICG dye had been injected into the patient upstream from the ROI but has not yet been introduced into the ROI, the enhanced ICG overlay can quantify the state of perfusion within the ROI as the clamp is released and blood flow is restored to the ROI. The method 1110 will detect ICG dye that is introduced into the ROI via the reperfusion flow, and the enhanced ICG overlay can quantify the state of perfusion within the ROI before the ICG dye causes image saturation within the ROI. In these and other embodiments, the method 1110 can average the amplitude (or another measure of strength of the signal) at a site within the ROI over a period of time (e.g., 3-5 seconds) to compute an indication of perfusion (e.g., a perfusion index) at the site. In this manner, the average strength of the pulsations at a site within the ROI can be assessed as a measure of local perfusion as the clamp is released and blood flow is restored to the ROI.

[0081] In these and still other embodiments, the method 1110 can compute an enhanced ICG overlay with percentage intensity contours derived from the RGB video sequence and/or the ICG video sequence. For example, FIG. 12 is a schematic image 1230 of a region of interest (ROI) 1237 illustrating pulsation contours 1239 plotted on top of the ICG view (produced at block 1114 of the method 1110) showing the ICG dye 1235 according to embodiments described herein. The method 1 1 10 can derive the pulsation contours 1239 from the RGB video sequence by iteratively applying a threshold(s) to the generated pulsation strength field and extracting boundaries from the resulting non-zero regions. In some embodiments, the threshold(s) can be predetermined and/or fixed. In these and other embodiments, the threshold(s) can be relative to a range of pulsation strength values present and/or calculated in the pulsation strength field. For example, the method 1110 can use a pulsation strength value with the largest magnitude in the pulsation strength field to define a 100% pulsation strength value. In these and other embodiments, the method 1110 can generate the pulsation contours 1239 by applying one or more threshold(s) at specific percentages (e.g., 20%, 40%, 60%, 80%, and/or one or more other percentages) of the 100% pulsation strength value to the generated pulsation strength field. As another example, FIG. 13 is a schematic image 1340 of a region of interest (ROI) 1347 illustrating ICG contours 1345 plotted on top of a pulsation field (computed at blocks 1115 and 1116 of tite method 1 110) according to embodiments described herein. The method 1110 can derive the ICG contours 1345 from the ICG video sequence in a manner similar to how the method 11 10 derives the pulsation contours 1239. For example, the method 1110 can derive the ICG contours 1345 by iteratively applying threshold(s) to the generated ICG view and extracting boundaries from the resulting non-zero regions. The threshold values can be predetermined, fixed, and/or relative to the range of ICG intensity values present and/or calculated in the generated ICG view.

[0082] At block 1121, the method 1110 can display one or more of the produced and/or computed views on a clinician display. For example, the method 1110 can display the RGB view, the ICG view, the computed pulsation field, the computed pulsation strength field, the standard ICG overlay, and/or the enhanced ICG overlay on the clinician display. In some embodiments, the method 11 10 can display one or more of the produced and/or computed views using various hues or colors to distinguish which view is currently displayed on the clinician display. For example, green can be used to indicate the presence of ICG dye within the ICG view, the standard ICG overlay, and/or the enhanced ICG overlay. In some embodiments, various hues of green and/or various colors can be used to indicate that other information (e.g., pulsation and/or pulsation strength) is currently displayed on the clinician display in addition to an indication of the presence of the ICG dye. For example, various hues of blue can be used to indicate pulsation strength. In these and other embodiments, various hues of red and/or yellow can be used to indicate pulsation. [0083] In some embodiments, the clinician display can be virtual, augmented, and/or mixed reality goggles. In these embodiments, a clinician can select a desired view from the one or more of the produced and/or computed views on the goggles. The method 1110 in some embodiments can update (e.g., adjust) a field of view of the desired view displayed on the goggles as the position and'or orientation of the goggles changes (e.g., as the clinician moves and-'or looks around).

[0084] FIG. 14 is a table 1450 illustrating possible ICG and RGB information combinations and corresponding interpretations according to embodiments described herein. In some embodiments, if the method 1110 displays strong ICG information and strong RGB information at a site within the ROI, the ROI likely has strong blood flow and perfusion at the site. Thus, the tissue at the site is likely viable. In these and other embodiments, if the method 1110 displays strong ICG information but weak or no RGB information at the site within the ROI, blood flow to the site (i) has likely been cut off subsequent to ICG dye injection and/or (ii) is likely very low. Thus, the tissue at the site is likely at risk of hypoxia. In these and still other embodiments, if the method 1 110 displays weak or no ICG information but strong RGB information at the site, the ROI likely has strong blood flow and perfusion at the site while the ICG dye has yet to be injected andfor was injected at the wrong site. In these and still other embodiments, if the method 1110 displays weak or no ICG information and weak or no RGB information at the site, the ROI likely does not have blood flow or perfusion at the site. Thus, the tissue at the site is likely at risk of hypoxia.

[0085] In some embodiments, the method 1110 can trigger an audio and/or visual alarm (e.g., on the clinician display) to indicate a concerning condition. For example, the method 1110 can trigger an audio and/or visual alarm if ICG dye is present at a site within the ROI and pulsations at the site cease or fall below a threshold value. This can indicate that there was blood flow to the site when the ICG dye was injected, but the site has become occluded and trapped ICG dye may not be metabolized. In these and other embodiments, the method 1110 can highlight the site on the clinician display. In these and still other embodiments, the method 1 110 can trigger different alarms for different events (e.g, the different combinations of information shown in the table 1450 in FIG. 14). For example, the method 1110 can trigger different alarms for the bottom three events illustrated in the table 1450, In these embodiments, the method 1 110 can trigger a fust audio and/or visual alarm when the method 1110 displays strong ICG information but weak or no RGB information, and a second audio and-'or visual alarm (e.g., different than the first audio and/or visual alarm) when the method 1 1 10 displays weak or no ICG information and weak or no RGB information. As a result, the method 1110 can alert a clinician that the site is at risk of hypoxia. In these and other embodiments, the method 1110 can trigger a third audio and/or visual alarm (e.g., an error alarm and/or an alarm different than the first and/or second alarms) when the method 11 10 displays weak or no ICG information but strong RGB information. As a result, the method 1110 can alert a clinician that ICG information is missing (e.g., due to a lack of ICG dye at a site within the ROI).

[0086] In this manner, the enhanced ICG overlay can decrease the likelihood that a clinician determines there is blood flow to the site when ICG dye is present only because a decrease and'or cessation in blood flow has slowed metabolism of the ICG dye at the site. In turn, subsequent injections of ICG dye can provide a better indication of blood flow to and/or within a region. Thus, the video-based patient monitoring systems and associated methods disclosed herein have the potential to improve recordkeeping, improve patient care, reduce errors in vital sign measurements, increase frequency and accuracy of blood flow monitoring, help healthcare providers better characterize and respond to adverse medical conditions indicated by a decrease and/or cessation in blood flow, and generally improve monitoring of patients, along with many other potential advantages discussed below.

[0087] Although the steps of the method 1 110 are discussed and illustrated in a particular order, the method 1110 in FIG. 11 is not so limited. In other embodiments, the method 1110 can be performed in a different order. In these and other embodiments, any of the steps of the method 1110 can be performed before, during, and/or after any of the other steps of the method 1110, Moreover, a person of ordinary skill in the relevant art will readily recognize that the illustrated method can be altered and still remain within these and other embodiments of the present technology. For example, one or more steps of the method 1110 illustrated in FIG. 11 can be omitted and/or repeated in some embodiments.

Additional Examples :

[0088] Several aspects of the present technology are set forth in the following examples.

1. A video-based patient monitoring system, comprising:

at least one processor; and

a non-contact detector having at least one video camera, wherein

the at least one video camera is configured to:

capture a red, green, blue (RGB) video sequence of a region of interest (ROl) to generate an RGB view of the ROI; and

capture an indocyanine green (ICG) video sequence of the ROI to generate an ICG view of the ROI, and

the at least one processor is configured to:

calculate color changes in pixels of RGB images within the RGB video sequence; and

assign one or more colors from a predetermined color scheme to Hie pixels of the RGB images based at least in part on the sign and/or magnitude of the color changes to generate a pulsation field.

2. The video-based patient monitoring system of example 1, wherein the at least one video camera includes an RGB video camera, an infrared (IR) video camera, and/or a monochrome camera with a filter.

3. The video-based patient monitoring system of example 1 further comprising a clinician display.

4. The video-based patient monitoring system of example 3, wherein the clinician display is an augmented, virtual, and/or mixed reality screen and/or goggle headset.

5. The video-based patient monitoring system of example 1, wherein the at least one processor is further configured to (i) superimpose the pulsation field onto the ICG view and/or (ii) blend the pulsation field with the ICG view to generate an enhanced ICG overlay view.

6. The video-based patient monitoring system of example 1, wherein the at least one processor is further configured to calculate percentage pulsation contours from the RGB video sequence and to superimpose the percentage pulsation contours onto the ICG view' to generate an enhanced ICG overlay view. 7. The video-based patient monitoring system of example 1, wherein the at least one processor is further configured to average magnitudes of the color changes to generate a pulsation strength field.

8. The video-based patient monitoring system of example 7, wherein the at least one processor is further configured to superimpose the pulsation strength field onto the ICG view to generate an enhanced ICG overlay view.

9. The video-based patient monitoring system of example 1, wherein the at least one processor is further configured to calculate percentage ICG contours from tire ICG video sequence and to superimpose the percentage ICG contours onto the RGB view to generate an enhanced ICG overlay view.

10. The video-based patient monitoring system of example 1, wherein the at least one video camera includes a filter, and/or wherein the video-based patient monitoring system further comprises a tuned IR light source configured to illuminate ICG dye within the ROI.

11. The video-based patient monitoring system of example 1, wherein the at least one video camera includes a stabilization element configured to hold the at least one video camera still spatially.

12. The video-based patient monitoring system of example 1 further comprising a blood pressure cuff configured to cut off blood supply to the ROl.

13. The video-based patient monitoring system of example 12 wherein the at least one processor, the at least one video camera, and the blood pressure cuff are coupled such that the at least one processor can automatically instruct the at least one video camera to capture the RGB video sequence and/or the ICG video sequence of the ROI when the blood pressure cuff cuts off blood supply to the ROI. 14. The video-based patient monitoring system of example 1 further comprising a pulse oximeter, wherein the at least one processor is further configured to calculate a perfusion index using the pulse oximeter to calibrate the video-based patient monitoring system to the ROI.

15. A method for assessing blood flow within a region of interest (ROI), the method comprising:

capturing a red, green, blue (RGB) video sequence of the ROI to generate an RGB view of the ROI, wherein the RGB video sequence of tire ROI comprises at least two RGB images of the ROI; and

generating a pulsation field across the ROI to indicate blood flow within the ROI.

16. The method of example 15, wherein generating a pulsation field across the ROI includes computing changes in colors of pixels in the at least two RGB images across the RGB video sequence and assigning one or more colors from a predetermined color scheme to the pixels based at least in part on the sign and/or magnitude of the color changes to generate a pulsation field.

17. The method of example 16, wherein computing the changes in the colors of the pixels in the at least two RGB images comprises computing the changes in the colors of the pixels in real time.

18. The method of example 16 further comprising (i) replacing the colors of the pixels in the RGB video sequence with the assigned one or more colors from the predetermined color scheme to generate a pulsation field view of the ROI and (ii) displaying the pulsation field view.

19. The method of example 15 further comprising generating a pulsation strength field across the ROI to indicate strength of pulsations within the ROI.

20. The method of example 19, wherein generating the pulsation strength field compnses—

averaging amplitudes of the changes in colors of the pixels across the RGB video sequence; and assigning one or more second colors from a second predetermined color scheme to the pixels based at least in part on magnitudes of the average amplitudes of the changes in the colors of the pixels.

21. The method of example 19 further comprising (i) superimposing the pulsation strength field onto the RGB video sequence to generate a pulsation strength field view and (ii) displaying the pulsation strength field view.

22. The method of example 20 further comprising (i) replacing the colors of the pixels in the RGB video sequence with the assigned one or more second colors from the second predetermined color scheme to generate a pulsation strength field view of the ROI and (ii) displaying the pulsation strength field view.

23, The method of example 15 further comprising capturing an indocyanine green (ICG) video sequence of the ROI to generate an ICG view of the ROI.

24. The method of examples 19 or 23 wherein generating the pulsation field and/or generating the pulsation strength field include using the ICG view of the ROI as a mask to remove background noise from the RGB view.

25. The method of example 23 further comprising generating a standard ICG overlay view by superimposing the RGB view onto the TCG view.

26. The method of example 23 further comprising generating a standard ICG overlay view by superimposing the ICG view onto the RGB view.

27. The method of example 23 further comprising generating an enhanced ICG overlay view. 28. The method of example 27, wherein generating the enhanced ICG overlay view includes (i) superimposing the pulsation field view and/or the pulsation strength field view onto the ICG view' and/or (ii) blending the pulsation field view and ^z or the pulsation strength field view with the ICG view.

29. The method of example 27, wherein generating the enhanced ICG overlay view includes calculating percentage pulsation contours from the RGB video sequence and superimposing the percentage pulsation contours onto the ICG view.

30. The method of example 27, wherein generating the enhanced ICG overlay view includes calculating percentage ICG contours from the ICG video sequence and superimposing the percentage ICG contours onto the pulsation field view'.

31. The method of examples 23, 24, 25, 26, 27, 28, 29, or 30 further comprising displaying tiie RGB view, the ICG view, the pulsation field view, the pulsation strength field view, the standard ICG overlay view, and/or the enhanced ICG overlay view on a clinician display.

32. The method of example 31, wherein the clinician display is an augmented, virtual, and/or mixed reality goggle headset and/or screen.

33. The method of examples 31 or 32, wherein displaying the RGB view, the ICG view, the pulsation field view, the pulsation strength field view, the standard ICG overlay view, and/or the enhanced ICG overlay view includes displaying the RGB view, the ICG view, the pulsation field view, the pulsation strength field view, the standard ICG overlay view, and ^z or the enhanced ICG overlay view in different colors and/or hues of colors from one another such that the different colors and/or hues indicate to a clinician a corresponding view that is currently displayed.

34, The method of example 15 further comprising triggering an audio and/or visual alarm when blood flow' at a site within the ROI is below' a predetermined threshold and/or when little to no RGB or ICG information is available and/or detected. 35. The method of example 34, wherein triggering an audio and/or visual alarm includes displaying the ROI and highlighting the site within the ROI.

36. The method of example 34, wherein triggering an audio and/or visual alarm includes triggering (i) a first audio and/or visual alarm when strong ICG information is detected at the site and little to no RGB information is detected at the site and (ii) a second audio and/or visual alarm when little to no ICG information and little to no RGB information is detected at the site.

37. The method of example 36, wherein triggering an audio and/or visual alarm further includes triggering a third audio and/or visual alarm when little to no ICG information is detected at the site and strong RGB information is detected at the site.

38. A method for assessing physiological parameter strength in a region of interest (ROI), the method comprising:

locking an image capture device in a first position;

capturing a red, green, blue (RGB) video sequence of the ROI using the image capture device; and

generating a physiological strength field of a physiological parameter of the ROI from the RGB video sequence.

39. The method of example 38 further comprising activating a physiological strength field feature of a video-based patient monitoring system.

40. The method of example 39, wherein activating the physiological strength field feature comprises actuating a hardware component on the video-based patient monitoring system, pressing a software button on a display of the video-based patient monitoring system, and/or instructing the video-based patient monitoring system to activate the physiological strength field feature via a voice command. 41. The method of example 38, wherein locking the image capture device in the first position includes locking the image capture device in the first position for a predetermined amount of time.

42. The method of example 41 , wherein capturing the RGB video sequence includes capturing the RGB video sequence for a period of time equivalent to the predetermined amount of time.

43. The method of example 38, wherein locking the image capture device in the first position includes locking the image capture device in the first position until a number of cardiac pulses and/or respiratory cycles have occurred.

44. The method of example 43, wherein capturing the RGB video sequence include capturing the RGB video sequence until the number of cardiac pulses and/or respiratory cycles have occurred.

45. The method of example 38, wherein the physiological parameter of the ROl includes pulsation, perfusion index, oxygen saturation, respiratory rate, and/or heart rate.

46. The method of example 38, wherein generating the physiological strength field of the physiological parameter includes assigning one or more colors and/or hues to pixels of the RGB video sequence corresponding to the ROl, wherein the one or more colors and/or hues correspond to magnitudes of the physiological parameters at the pixels corresponding to the ROl.

47. The method of example 38, wherein generating the physiological strength field includes generating the physiological strength field across a whole field of view of the image capture device, wherein the method further comprises displaying a first portion of the generated physiological strength field corresponding to an active field of view of the image capture device, and wherein the active field of view is a subset of the whole field of view. 48, The method of example 47 further comprising, when the image capture device is moved to a second position such that a second portion of the generated physiological strength field corresponds to the active field of view of the image capture device, instantly displaying the second portion of the generated physiological strength field.

49. The method of example 47, wherein the generated physiological strength field is a first physiological strength field, and wherein, when the image capture device is moved to a second position, the method further comprises—

generating a second physiological strength field across the whole field of view of the image capture device, and

displaying a first portion of the second generated physiological strength field corresponding to the active field of view of the image capture device.

50. A method for identifying one or more sites of low perfusion within a region of interest

(ROI), the method comprising:

capturing a pre-cut off video sequence of the ROI;

cutting off blood supply to the ROI;

capturing a post-cut off video sequence of the ROI; and

comparing the pre-cut off video sequence of the ROI to the post-cut off video sequence of the ROI to identify one or more sites of low perfusion within the ROI, wherein comparing the pre-cut off video sequence to the post-cut off video sequence includes determining whether at least a predetermined number of adjacent pixels and/or adjacent groups of pixels in the post-cut off video sequence corresponding to a site within the ROI maintained light intensity and/or color values within a predetermined range of light intensity and/or color values of corresponding pixels in the pre-cut off video sequence.

51. The method of example 50 further comprising, when at least the predetermined number of adjacent pixels and/or adjacent groups of pixels in the post-cut off video sequence corresponding to the site within the ROI maintained light intensity and/or color values within a predetermined range of light intensity and/or color values of corresponding pixels in the pre-cut off video sequence, indicating the site as a low perfusion site within the ROI. 52. The method of example 51, wherein indicating the site as a low perfusion site within the ROI include highlighting the site on a display of the ROI and/or triggering an audio and/or visual alarm.

53. The method of example 50 further comprising calibrating a video-based patient monitoring system to the ROI by measuring a perfusion index of the ROI with a pulse oximeter attached on or near the ROI.

54. The method of example 53, wherein comparing the pre-cut off video sequence of the ROI to the post-cut off video sequence of the ROI includes comparing absolute values of light intensities and/or colors of pixels in the post-cut off video sequence to absolute values of light intensities and/or colors of corresponding pixels in the pre-cut off video sequence.

55. The method of example 50, wherein comparing the pre-cut off video sequence of the ROI to the post-cut off video sequence of the ROI includes calculating a relative change in light intensities and/or colors of pixels in the post-cut off video sequence from light intensities and-'or colors of corresponding pixels in the pre-cut off video sequence.

56. The method of example 50, wherein capturing the pre-cut off and post-cut off video sequences includes capturing the pre-cut off and post-cut off video sequences using an image capture device, and wherein cutting off the blood supply to the ROI includes cutting off the blood supply to the ROI using a blood pressure cuff coupled to the image capture device.

57. The method of example 56, wherein capturing the post-cut off video sequence of the ROI includes automatically capturing the post-cut off video sequence after cutting off the blood supply to the ROI.

Conclusion

[0089] The above detailed descriptions of embodiments of the technology are not intended to be exhaustive or to limit the technology to the precise form disclosed above. Although specific embodiments of, and examples for, the technology are described above for illustrative purposes, various equivalent modifications are possible within the scope of the technology, as those skilled in the relevant art will recognize. For example, while steps are presented in a given order, alternative embodiments may perform steps in a different order. Furthermore, the various embodiments described herein may also be combined to provide further embodiments.

[00901 The systems and methods described here may be provided in the form of tangible and non-transitory machine-readable medium or media (such as a hard disk drive, hardware memory, etc.) having instructions recorded thereon for execution by a processor or computer. The set of instructions may include various commands that instruct the computer or processor to perform specific operations such as the methods and processes of the various embodiments described here. The set of instructions may be in the fomi of a software program or application. The computer storage media may include volatile and non-volatile media, and removable and non-removable media, for storage of information such as computer-readable instructions, data structures, program modules or other data. The computer storage media may include, but are not limited to, RAM, ROM, EPROM, EEPROM, flash memory or other solid-state memory technology, CD-ROM, DVD, or other optical storage, magnetic disk storage, or any other hardware medium which may be used to store desired information and that may be accessed by components of the system. Components of the system may communicate with each other via wired or wireless communication. The components may be separate from each other, or various combinations of components may be integrated together into a medical monitor or processor, or contained within a workstation with standard computer hardware (for example, processors, circuitry, logic circuits, memory, and the like). The system may include processing devices such as microprocessors, microcontrollers, integrated circuits, control units, storage media, and other hardware.

[0091] From the foregoing, it will be appreciated that specific embodiments of the technology have been described herein for purposes of illustration, but well-known structures and functions have not been shown or described in detail to avoid unnecessarily obscuring the description of the embodiments of the technology. To the extent any material incorporated herein by reference conflicts with the present disclosure, the present disclosure controls. Where the context permits, singular or plural terms may also include the plural or singular term, respectively. Moreover, unless the word "or" is expressly limited to mean only a single item exclusive from the other items in reference to a list of two or more items, then the use of "or" in such a list is to be interpreted as including (a) any single item in the list, (b) all of the items in the list, or (c) any combination of the items in the list. Where the context permits, singular or plural terms may also include the plural or singular term, respectively. Furthermore, as used herein, the phrase“and/or” as in“A and/or B” refers to A alone, B alone, and both A and B. Additionally, the terms "comprising,"“including,”“having” and“with” are used throughout to mean including at least the recited feature(s) such that any greater number of the same feature and/or additional types of other features are not precluded.

[0092] From the foregoing, it will also be appreciated that various modifications may be made without deviating from the technology. For example, various components of the technology can be further divided into subcomponents, or that various components and functions of the technology may be combined and/or integrated. Furthermore, although advantages associated with certain embodiments of the technology have been described in the context of those embodiments, other embodiments may also exhibit such advantages, and not all embodiments need necessarily exhibit such advantages to fall within the scope of the technology. Accordingly, the disclosure and associated technology can encompass other embodiments not expressly shown or described herein.