HERMANN JOHANNES (US)
WO2012037547A2 | 2012-03-22 |
US20170258741A1 | 2017-09-14 | |||
US20150250808A1 | 2015-09-10 | |||
US20190202801A1 | 2019-07-04 | |||
US20190290778A1 | 2019-09-26 |
WHAT IS CLAIMED IS: 1. A compound comprising a monovalent cellular component binder covalently bound to a monovalent targeted autophagy protein binder, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: , wherein z1 is an integer from 0-9; wherein z1 is an integer from 0-11; wherein z1 is an integer from 0-12; , wherein z1 is an integer from 0-10; wherein Z is O, S, or SO2, and z1 is an integer from 0-10; wherein W is O, NH, NR1, or CH2; n is 0 or 1; z1 is an integer from 0-11; and z3 is an integer from 0-5; wherein z1 is an integer from 0-2, and z3 is an integer from 0-5; R1 is independently oxo, halogen, -CX13, -CHX12, -CH2X1, -OCX13, -OCH2X1, -OCHX12, -CN, -SOn1R1D, -SOv1NR1AR1B, -NHC(O)NR1AR1B, -N(O)m1, -NR1AR1B, -C(O)R1C, -C(O)-OR1C, -C(O)NR1AR1B, -OR1D, -NR1ASO2R1D, -NR1AC(O)R1C, -NR1AC(O)OR1C, -NR1AOR1C, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or two R1 substituents are taken together to form a substituted or unsubstituted alkylene, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or one R1 substituent is taken together with R2 to form a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; R2 is independently H, oxo, halogen, -CX23, -CHX22, -CH2X2, -OCX23, -OCH2X2, -OCHX22, -CN, -SOn2R2D, -SOv2NR2AR2B, -NHC(O)NR2AR2B, -N(O)m2, -NR2AR2B, -C(O)R2C, -C(O)-OR2C, -C(O)NR2AR2B, -OR2D, -NR2ASO2R2D, -NR2AC(O)R2C, -NR2AC(O)OR2C,-NR2AOR2C, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or R2 is taken together with one R1 substituent to form a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; R3 is independently oxo, halogen, -CX33, -CHX32, -CH2X3, -OCX33, - OCH2X3, -OCHX32, -CN, -SOn3R3D, -SOv3NR3AR3B, -NHC(O)NR3AR3B, -N(O)m3, -NR3AR3B, -C(O)R3C, -C(O)-OR3C, -C(O)NR3AR3B, -OR3D, -NR3ASO2R3D, -NR3AC(O)R3C, -NR3AC(O)O R3C,-NR3AOR3C, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or two R3 substituents are taken together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L5 is a bond, -S(O)2-, -S(O)-, -NR5-, =N-, -O-, -S-, -C(O)-, -C(O)NR5-, -NR5C(O)-, -NR5C(O)NH-, -NHC(O)NR5-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; R5 is hydrogen, -CX53, -CHX52, -CH2X5, -OCX53, -OCH2X5, -OCHX52, -CN, -C(O)R5C, -C(O)-OR5C, -C(O)NR5AR5B, -OR5D, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; L6 is a bond, -S(O)2-, -S(O)-, -NR6-, =N-, -O-, -S-, -C(O)-, -C(O)NR6-, -NR6C(O)-, -NR6C(O)NH-, -NHC(O)NR6-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; R6 is hydrogen, -CX63, -CHX62, -CH2X6, -OCX63, -OCH2X6, -OCHX62, -CN, -C(O)R6C, -C(O)-OR6C, -C(O)NR6AR6B, -OR6D, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R1A, R1B, R1C, R1D, R2A, R2B, R2C, R2D, R3A, R3B, R3C, R3D, R5A, R5B, R5C, R5D, R6A, R6B, R6C, and R6D are independently hydrogen, -CX3, -CN, -COOH, -CONH2, -CHX2, -CH2X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R1A and R1B substituents bonded to the same nitrogen atom can be taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R2A and R2B substituents bonded to the same nitrogen atom can be taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R3A and R3B substituents bonded to the same nitrogen atom can be taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R5A and R5B substituents bonded to the same nitrogen atom can be taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R6A and R6B substituents bonded to the same nitrogen atom can be taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; X, X1, X2, X3, X5, and X6 are independently -F, -C1, -Br, or -I; n1, n2, and n3 are independently an integer from 0 to 4; and m1, m2, m3, v1, v2, and v3 are independently 1 or 2. 2. The compound of claim 1, wherein a divalent linker binds said monovalent cellular component binder to said monovalent targeted autophagy protein binder. 3. The compound of claim 1 or 2, wherein the cellular component is a protein, ion, lipid, nucleic acid, nucleotide, amino acid, particle, organelle, cellular compartment, microorganism, virus, lipid droplet, vesicle, small molecule, protein complex, protein aggregate, or macromolecule. 4. The compound of claim 3, wherein the cellular component is associated with a disease. 5. The compound of claim 4, wherein the disease is cancer, a neurodegenerative disease, a metabolic disease, an infectious disease, an autoimmune disease, or an inflammatory disease. 6. The compound of claim 2, wherein the divalent linker has the formula -L1-L2-L3-L4-, wherein: L1 is connected directly to said monovalent targeted autophagy protein binder; L1 is -S(O)2-, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; L2 is a bond, -S(O)2-, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; L3 is a bond, -S(O)2-, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; and L4 is a bond, -S(O)2-, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. 7. The compound of any one of claims 1-6, wherein the targeted autophagy protein binder is capable of contacting an amino acid corresponding to C26 of human p62/SQSTM1 protein. 8. The compound of any one of claims 1-6, wherein the targeted autophagy protein binder is capable of contacting an amino acid corresponding to C27 of human p62/SQSTM1protein. 9. The compound of any one of claims 1-6, wherein the targeted autophagy protein binder is capable of contacting an amino acid corresponding to C113 of human p62/SQSTM1protein. 10. The compound of any one of claims 7-9, wherein the targeted autophagy protein binder is capable of forming a covalent bond to the cysteine. 11. The compound of any one of claims 1-10, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: wherein z1 is an integer from 0-9. 12. The compound of claim 11, wherein z1 is 0, 1, or 2. 13. The compound of claim 11 or 12, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 14. The compound of any one of claims 11-13, wherein: R2 is H, -C(O)-OR2C, or substituted or unsubstituted alkyl; and R2C is substituted or unsubstituted alkyl. 15. The compound of claim 14, wherein: R2 is H or -C(O)OC(CH3)3. 16. The compound of any one of claims 11, 12, 14, and 15, wherein: each R1 is independently halogen, or substituted or unsubstituted alkyl. 17. The compound of claim 16, wherein: each R1 is independently -F, -C1, or -CH3. 18. The compound of any one of claims 11-17, wherein: R5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl. 19. The compound of claim 18, wherein: R5 20. The compound of any one of claims 11-19, wherein: L5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. 21. The compound of claim 20, wherein: L5 and L6 are each a bond. 22. The compound of any one of claims 11-21, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 23. The compound of any one of claims 1-10, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 24. The compound of claim 23, wherein z1 is 0, 1, or 2. 25. The compound of claim 23 or 24, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 26. The compound of any one of claims 23-25, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 27. The compound of any one of claims 23-26, wherein: R2 is H, -C(O)-OR2C, or substituted or unsubstituted alkyl; and R2C is substituted or unsubstituted alkyl. 28. The compound of claim 27, wherein: R2 is H or -C(O)OC(CH3)3. 29. The compound of any one of claims 23-28, wherein: R5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl. 30. The compound of claim 29, wherein: R5 is isopropyl. 31. The compound of any one of claims 23-30, wherein: L5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. 32. The compound of claim 31, wherein: L5 and L6 are each a bond. 33. The compound of any one of claims 23-32, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 34. The compound of any one of claims 1-10, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 35. The compound of claim 34, wherein z1 is 1, 2, or 3. 36. The compound of claim 34 or 35, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: (III-j) , wherein the Ring A moiety is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. 37. The compound of any one of claims 34-36, wherein: each R1 is independently oxo, halogen, -CX13, -CHX12, -CH2X1, -NR1AR1B, -C(O)-OR1C, -NR1AC(O)OR1C, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; or two R1 substituents are taken together to form a substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl; each R1A, R1B, and R1C is independently hydrogen, or substituted or unsubstituted alkyl; and each X1 is independently -F or -C1. 38. The compound of claim 37, wherein: each R1 is independently F, -CH3, -OH, -CF3, -CH2F, -C(O)OCH2CH3, -NH2, oxo, -CH2N(H)C(O)OCH2(C6H5), or -N(H)C(O)OC(CH3)3; O or two R1 groups are taken together to form 39. The compound of any one of claims 34-38, wherein: L5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. 40. The compound of claim 39, wherein: L5 and L6 are each a bond. 41. The compound of any one of claims 34-40, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 42. The compound of any one of claims 1-10, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 43. The compound of claim 42, wherein z1 is 0, 1, or 2. 44. The compound of claim 42 or 43, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: wherein the Ring A moiety is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. 45. The compound of any one of claims 42-44, wherein: each R1 is independently halogen, -CX13, -OR1D, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; or two R1 substituents are taken together to form a substituted or unsubstituted alkylene, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl; or one R1 substituent is taken together with R2 to form a substituted or unsubstituted heteroaryl; each R1D is independently hydrogen, or substituted or unsubstituted alkyl; and each X1 is independently -F or -C1. 46. The compound of claim 45, wherein: each R1 is independently -CH3 or -OH; or two R1 groups are taken together to form -CH2-, or R1 and R2 are taken together to form 47. The compound of any one of claims 42-46, wherein: each R2 is independently hydrogen, substituted or unsubstituted alkyl, -C(O)OR2C, or substituted or unsubstituted heteroaryl; or R2 is taken together with one R1 substituent to form a substituted or unsubstituted heteroaryl; and each R2C is independently substituted or unsubstituted alkyl. 48. The compound of claim 47, wherein: R2 is H, -CH2CH3, -C(O)OCH3, -C(O)OC(CH3)3, or or R2 and R1 are taken together to form 49. The compound of any one of claims 42-48, wherein: L5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. 50. The compound of claim 49, wherein: L5 and L6 are each a bond. 51. The compound of any one of claims 42-50, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: , , 52. The compound of any one of claims 1-10, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: . 53. The compound of claim 51, wherein z1 is 0-3. 54. The compound of claim 52 or 53, wherein Z is O. 55. The compound of claim 54, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 56. The compound of claim 52 or 53, wherein Z is S. 57. The compound of claim 56, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 58. The compound of claim 52 or 53, wherein Z is SO2. 59. The compound of claim 58, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 60. The compound of any one of claims 52-59, wherein: each R1 is independently halogen, -CX13, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; or two R1 substituents are taken together to form a substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl; and each X1 is independently -F or -C1. 61. The compound of claim 60, wherein: each R1 is independently -CH3 or F; or two R1 substituents are taken together to form 62. The compound of any one of claims 52-61, wherein: L5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. 63. The compound of claim 62, wherein: L5 and L6 are each a bond. 64. The compound of any one of claims 52-63, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 65. The compound of any one of claims 1-10, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 66. The compound of claim 65, wherein z1 is 0-3. 67. The compound of claim 65 or 66, wherein z3 is 0-2. 68. The compound of any one of claims 65-67, wherein n is 0. 69. The compound of any one of claims 65-67, wherein n is 1. 70. The compound of any one of claims 65-69, wherein W is CH2. 71. The compound of claim 70, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 72. The compound of any one of claims 65-69, wherein W is O. 73. The compound of claim 72, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 74. The compound of any one of claims 65-69, wherein W is NH or NR1. 75. The compound of claim 74, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: 76. The compound of claim 75, wherein: each R1 is independently oxo, halogen, -OR1D, or substituted or unsubstituted alkyl; and each R1D is independently hydrogen, or substituted or unsubstituted alkyl. 77. The compound of claim 76, wherein: each R1 is independently -CH2OH, -OH, oxo, or -CH2(C6H5). 78. The compound of any one of claims 65-77, wherein: L5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. 79. The compound of claim 78, wherein: L5 and L6 are each a bond. 80. The compound of any one of claims 65-79, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: , . 81. The compound of any one of claims 1-10, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: . 82. The compound of claim 81, wherein z1 is an integer from 0 or 1. 83. The compound of claim 81 or 82, where z3 is 0, 1, or 2. 84. The compound of any one of claims 81-83, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: . 85. The compound of any one of claims 81-83, wherein: each R1 is independently halogen, -CX13, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; and each X1 is independently -F or -C1. 86. The compound of claim 85, wherein: each R1 is independently -F or -CH3. 87. The compound of any one of claims 81-86, wherein: each R3 is independently halogen, -OR3D, or substituted or unsubstituted alkyl; and each R3D is independently hydrogen, or substituted or unsubstituted alkyl. 88. The compound of claim 87, wherein: each R3 is -OCH3. 89. The compound of any one of claims 81-88, wherein: L5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. 90. The compound of claim 89, wherein: L5 and L6 are each a bond. 91. The compound of any one of claims 81-90, wherein the monovalent targeted autophagy protein binder is a monovalent form of the formula: . 92. The compound of any one of claims 1-91, wherein the monovalent cellular component binder is a substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. 93. The compound of any one of claims 1-92, wherein the monovalent cellular component binder is capable of binding BRD4. 94. The compound of claim 93, wherein the monovalent cellular component binder has the formula: . 95. The compound of any one of claims 1-91, wherein the monovalent cellular component binder is capable of binding a protein aggregate. 96. The compound of claim 95, wherein the monovalent cellular component binder is capable of binding a huntingtin aggregate. 97. The compound of claim 96, wherein the monovalent cellular component binder is capable of binding a PolyQ huntingtin aggregate. 98. The compound of claim 95, wherein the monovalent cellular component binder is capable of binding an amyloid protein aggregate. 99. The compound of claim 95, wherein the monovalent cellular component binder is capable of binding a protein aggregate comprising a protein selected from the group consisting of amyloid precursor protein, beta amyloid, IAPP, alpha-synuclein, PrP, prion protein Sc, Huntingtin, calcitonin, atrial natriuretic factor, apolipoprotein A1, Serum amyloid A, medin, prolactin, transthyretin, lysozyme, beta-2 microglobulin, gelsolin, keratoepithelin, cystatin, immunoglobulin light chain AL, and S-IBM. 100. The compound of claim 95, wherein the monovalent cellular component binder is a monovalent form of thioflavin or a derivative thereof. 101. The compound of claim 95, wherein the monovalent cellular component binder is a 102. The compound of claim 95, wherein the monovalent cellular component binder is a monovalent form of the formula: . 103. The compound of claim 95, wherein the monovalent cellular component binder has the formula: 104. The compound of claim 95, wherein the monovalent cellular component binder has the formula: . 105. An autophagy adapter protein covalently bonded to a fragment of the compound of any one of claims 1-104. 106. The autophagy adapter protein of claim 105, wherein the autophagy adapter protein is p62 or a derivative, fragment, or homolog thereof. 107. A pharmaceutical composition comprising the compound of any one of claims 1-104 and a pharmaceutically acceptable excipient. 108. A method of reducing the level of a cellular component, said method comprising contacting the cellular component with a targeted autophagy degrader, wherein the targeted autophagy degrader is the compound of any one of claims 1-104. 109. The method of claim 108, further comprising: A) allowing formation of an autophagosome comprising the compound of claim 1; B) allowing the autophagosome to acidify; and C) allowing degradation of the cellular component. 110. A method of treating cancer, said method comprising contacting a cellular component associated with cancer with the compound of any one of claims 1-104. 111. A method of treating cancer, said method comprising administering to a subject in need thereof a therapeutically effective amount of the compound of any one of claims 1-104. 112. A method of treating neurodegenerative disease, said method comprising contacting a cellular component associated with the neurodegenerative disease with the compound of any one of claims 1-104. 113. A method of treating a neurodegenerative disease, said method comprising administering to a subject in need thereof a therapeutically effective amount of the compound of any one of claims 1-104. 114. The method of claim 113, wherein said neurodegenerative disease is Huntington Disease, Alzheimer Disease, or Parkinson’s Disease. 115. A method of treating a metabolic disease, said method comprising contacting a cellular component associated with the metabolic disease with the compound of any one of claims 1-104. 116. A method of treating a metabolic disease, said method comprising administering to a subject in need thereof a therapeutically effective amount of the compound of any one of claims 1-104. 117. A method of treating an infectious disease, said method comprising contacting a cellular component associated with the infectious disease with the compound of any one of claims 1-104. 118. A method of treating an infectious disease, said method comprising administering to a subject in need thereof a therapeutically effective amount of the compound of any one of claims 1-104. 119. A method of treating an autoimmune disease, said method comprising contacting a cellular component associated with the autoimmune disease with the compound of any one of claims 1-104. 120. A method of treating an autoimmune disease, said method comprising administering to a subject in need thereof a therapeutically effective amount of the compound of any one of claims 1-104. 121. A method of treating an inflammatory disease, said method comprising contacting a cellular component associated with the inflammatory disease with the compound of any one of claims 1-104. 122. A method of treating an inflammatory disease, said method comprising administering to a subject in need thereof a therapeutically effective amount of the compound of any one of claims 1-104. 123. The method of claim 108, wherein the cellular component binder is associated with a disease. 124. The method of claim 123, wherein the disease is cancer, a neurodegenerative disease, a metabolic disease, an infectious disease, an autoimmune disease, or an inflammatory disease. 125. The method of claim 108, wherein the cellular component is a protein, ion, lipid, nucleic acid, nucleotide, amino acid, particle, organelle, cellular compartment, microorganism, virus, vesicle, small molecule, protein complex, protein aggregate, or macromolecule. |
[0171] In some embodiments, formula (A) is formula (II) or any variation or embodiment thereof. [0172] In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: , wherein z1 is an integer from 0-12. In some embodiments, z1 is 1, 2, or 3. In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula:
wherein the Ring A moiety is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. [0173] In some embodiments or variations of formula (III) and (III-a)-(III-j), each R 1 is independently oxo, halogen, -CX 1 3 , -CHX 1 2 , -CH 2 X 1 , -NR 1A R 1B , -C(O)-OR 1C , -NR 1A C(O)OR 1C , substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; or two R 1 substituents are taken together to form a substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl; each R 1A , R 1B , and R 1C is independently hydrogen, or substituted or unsubstituted alkyl; and each X 1 is independently -F or -C1. In some embodiments, each R 1 is independently F, -CH 3 , -OH, -CF 3 , -CH 2 F, -C(O)OCH 2 CH 3 , -NH 2 , oxo, -CH 2 N(H)C(O)OCH 2 (C 6 H 5 ), or -N(H)C(O)OC(CH 3 ) 3 ; or two R 1 groups are taken together to form [0174] In some embodiments or variations of formula (III) and (III-a)-(III-j), L 5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L 6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. In some embodiments, L 5 and L 6 are each a bond. [0175] In some embodiments or variations of formula (III) and (III-a)-(III-j), the monovalent targeted autophagy protein binder is a monovalent form of the formula: ,
[0176] In some embodiments, formula (B) is formula (III) or any variation or embodiment thereof. [0177] In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: , wherein z1 is an integar from 0-10. In some embodiments, z1 is 0, 1, or 2. In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: wherein the Ring A moiety is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. [0178] In some embodiments or variations of formula (IV) and (IV-a)-(IV-i), each R 1 is independently halogen, -CX 1 3 , -OR 1D , substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; or two R 1 substituents are taken together to form a substituted or unsubstituted alkylene, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl; or one R 1 substituent is taken together with R 2 to form a substituted or unsubstituted heteroaryl; each R 1D is independently hydrogen, or substituted or unsubstituted alkyl; and each X 1 is independently -F or -C1. In some embodiments, each R 1 is independently -CH 3 or -OH; or two R 1 groups are taken together to form -CH 2 -, , are taken together to form [0179] In some embodiments or variations of formula (IV) and (IV-a)-(IV-i), each R 2 is independently hydrogen, substituted or unsubstituted alkyl, -C(O)OR 2C , or substituted or unsubstituted heteroaryl; or R 2 is taken together with one R 1 substituent to form a substituted or unsubstituted heteroaryl; and each R 2C is independently substituted or unsubstituted alkyl. In some embodiments, R 2 is H, -CH 2 CH 3 , -C(O)OCH 3 , -C(O)OC(CH 3 ) 3 , or or R 2 and R 1 are taken together to form [0180] In some embodiments or variations of formula (IV) and (IV-a)-(IV-i), L 5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L 6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. In some embodiments, L 5 and L 6 are each a bond. [0181] In some embodiments or variations of formula (IV) and (IV-a)-(IV-i), the monovalent targeted autophagy protein binder is a monovalent form of the formula: ,
[0182] In some embodiments, formula (B) is formula (IV) or any variation or embodiment thereof. [0183] In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: , wherein Z is O, S, or SO 2 , and z1 is an integer from 0-10. In some embodiments, z1 is 0-3. [0184] In some embodiments, Z is O. In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: (V-a), (V-b), (V-c), or (V-d) . [0185] In some embodiments, Z is S. In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: [0186] In some embodiments, Z is SO 2 . In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: [0187] In some embodiments or variations of formula (V) and (V-a)-(V-h), each R 1 is independently halogen, -CX 1 3, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; or two R 1 substituents are taken together to form a substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl; and each X 1 is independently -F or -C1. In some embodiments, each R 1 is independently -CH 3 or F; or two R 1 substituents are taken together to form [0188] In some embodiments or variations of formula (V) and (V-a)-(V-h), L 5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L 6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. In some embodiments, L 5 and L 6 are each a bond. [0189] In some embodiments or variations of formula (V) and (V-a)-(V-h), the monovalent targeted autophagy protein binder is a monovalent form of the formula: [0190] In some embodiments, formula (B) is formula (V) or any variation or embodiment thereof. [0191] In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: , wherein W is O, NH, NR 1 , or CH 2 ; n is 0 or 1; z1 is an integer from 0-11; and z3 is an integer from 0-5. In some embodiments, z1 is 0-3. In some embodiments, z3 is 0-2. In some embodiments, n is 0. In some embodiments, n is 1. [0192] In some embodiments of formula (VI), W is CH 2 . In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: [0193] In some embodiments of formula (VI), W is O. In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: [0194] In some embodiments of formula (VI), W is NH or NR 1 . In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: (VI-g) or (VI-h) . [0195] In some embodiments or variations of formula (VI) and (VI-a)-(VI-h), each R 1 is independently oxo, halogen, -OR 1D , or substituted or unsubstituted alkyl; and each R 1D is independently hydrogen, or substituted or unsubstituted alkyl. In some embodiments, each R 1 is independently -CH 2 OH, -OH, oxo, or -CH 2 (C 6 H 5 ). [0196] In some embodiments or variations of formula (VI) and (VI-a)-(VI-h), L 5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L 6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. In some embodiments, L 5 and L 6 are each a bond. [0197] In some embodiments or variations of formula (VI) and (VI-a)-(VI-h), the monovalent targeted autophagy protein binder is a monovalent form of the formula: , . [0198] In some embodiments, formula (C) is formula (VI) or any variation or embodiment thereof. [0199] In some embodiments, the monovalent targeted autophagy protein binder is a monovalent form of the formula: , wherein z1 is an integer from 0-2, and z3 is an integer from 0- 5. In some embodiments, z1 is an integer from 0 or 1. In some embodiments, z3 is 0, 1, or 2. [0200] In some embodiments of formula (VII), the monovalent targeted autophagy protein binder is a monovalent form of the formula: . [0201] In some embodiments or variations of formula (VII) and (VII-a), each R 1 is independently halogen, -CX 1 3, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; and each X 1 is independently -F or -C1. In some embodiments, each R 1 is independently -F or -CH 3 . [0202] In some embodiments or variations of formula (VII) and (VII-a), each R 3 is independently halogen, -OR 3D , or substituted or unsubstituted alkyl; and each R 3D is independently hydrogen, or substituted or unsubstituted alkyl. In some embodiments, each R 3 is -OCH 3 . [0203] In some embodiments or variations of formula (VII) and (VII-a), L 5 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene; and L 6 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene. In some embodiments, L 5 and L 6 are each a bond. [0204] In some embodiments or variations of formula (VII) and (VII-a), the monovalent targeted autophagy protein binder is a monovalent form of the formula: . [0205] It will be understood that floating R-substituents in the formulae described herein (such as R 1 and R 3 ) may be positioned on any ring in a fused or bridged ring system even though the formula may show the floating R-substituent on a single ring. [0206] In some embodiments, formula (C) is formula (VII) or any variation or embodiment thereof. [0207] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, R 1 is independently oxo, halogen, -CX 1 3 , -CHX 1 2 , -CH 2 X 1 , -OCX 1 3, -OCH 2 X 1 , -OCHX 1 2, -CN, -SOn1R 1D , -SOv1NR 1A R 1B , -NHC(O)NR 1A R 1B , -N(O)m1, -NR 1A R 1B , -C(O)R 1C , -C(O)-OR 1C , -C(O)NR 1A R 1B , -OR 1D , -NR 1A SO 2 R 1D , -NR 1A C(O)R 1C , -NR 1A C(O)OR 1C , -NR 1A OR 1C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. In some embodiments, two R 1 substituents are taken together to form a substituted or unsubstituted alkylene, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. In some embodiments, one R 1 substituent is taken together with R 2 to form a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl. [0208] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, R 2 is independently H, oxo, halogen, -CX 2 3, -CHX 2 2, -CH 2 X 2 , -OCX 2 3, -OCH 2 X 2 , -OCHX 2 2, -CN, -SOn2R 2D , -SOv2NR 2A R 2B , -NHC(O)NR 2A R 2B , -N(O) m2 , -NR 2A R 2B , -C(O)R 2C , -C(O)-OR 2C , -C(O)NR 2A R 2B , -OR 2D , -NR 2A SO 2 R 2D , -NR 2A C(O)R 2C , -NR 2A C(O)OR 2C , -NR 2A OR 2C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. In some embodiments, R 2 is taken together with one R 1 substituent to form a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl. [0209] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, R 3 is independently oxo, halogen, -CX 3 3, -CHX 3 2, -CH 2 X 3 , -OCX 3 3 , -OCH 2 X 3 , -OCHX 3 2 , -CN, -SO n3 R 3D , -SO v3 NR 3A R 3B , -NHC(O)NR 3A R 3B , -N(O) m3 , -NR 3A R 3B , -C(O)R 3C , -C(O)-OR 3C , -C(O)NR 3A R 3B , -OR 3D , -NR 3A SO 2 R 3D , -NR 3A C(O)R 3C , -NR 3A C(O)OR 3C , -NR 3A OR 3C , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. In some embodiments, two R 3 substituents are taken together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. [0210] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, . [0211] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, L 5 is a bond, -S(O) 2 -, -S(O)-, -NR 5 -, =N-, -O-, -S-, -C(O)-, -C(O)NR 5 -, -NR 5 C(O)-, -NR 5 C(O)NH-, -NHC(O)NR 5 -, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. It will be understood that selection of L 5 obeys standard rules of chemical valency known in the chemical arts and forms a chemical bond according to standard rules of chemical bonding. [0212] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, R 5 is hydrogen, -CX 5 3 , -CHX 5 2 , -CH 2 X 5 , -OCX 5 3 , -OCH 2 X 5 , -OCHX 5 2, -CN, -C(O)R 5C , -C(O)-OR 5C , -C(O)NR 5A R 5B , -OR 5D , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. [0213] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, L 6 is a bond, -S(O) 2 -, -S(O)-, -NR 6 -, =N-, -O-, -S-, -C(O)-, -C(O)NR 6 -, -NR 6 C(O)-, -NR 6 C(O)NH-, -NHC(O)NR 6 -, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. It will be understood that selection of L 6 obeys standard rules of chemical valency known in the chemical arts and forms a chemical bond according to standard rules of chemical bonding. [0214] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, R 6 is hydrogen, -CX 6 3 , -CHX 6 2 , -CH 2 X 6 , -OCX 6 3 , -OCH 2 X 6 , -OCHX 6 2, -CN, -C(O)R 6C , -C(O)-OR 6C , -C(O)NR 6A R 6B , -OR 6D , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. [0215] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, R 1A , R 1B , R 1C , R 1D , R 2A , R 2B , R 2C , R 2D , R 3A , R 3B , R 3C , R 3D , R 5A , R 5B , R 5C , R 5D , R 6A , R 6B , R 6C , and R 6D are independently hydrogen, -CX3, -CN, -COOH, -CONH 2 , -CHX 2 , -CH 2 X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl. In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl. In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl. In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl. In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are taken together to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl. [0216] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, X, X 1 , X 2 , X 3 , X 5 , and X 6 are independently -F, -C1, -Br, or -I. [0217] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, n1, n2, and n3 are independently an integer from 0 to 4; and m1, m2, m3, v1, v2, and v3 are independently 1 or 2. [0218] In some of the embodiments and variations of formula (I), (II), (III), (IV), (V), (VI), and (VII) described herein, each of L 5 and L 6 is a bond and –L 5 -L 6 -R 4 is –R 4 . In some embodiments, R 4 In some embodiments, –L 5 -L 6 -R 4 is [0219] In some embodiments, R 1 is independently halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -O C1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -N 3 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0220] In some embodiments, R 1 is independently substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1 is independently substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1 is independently substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1 is independently substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1 is independently substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1 is independently substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1 is independently an unsubstituted cycloalkyl (e.g., C 3 - C8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1 is independently substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1 is independently substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1 is independently substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1 is independently substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1 is independently substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1 is independently substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0221] In some embodiments, R 1 is independently halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , R 21 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 21 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 21 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 21 - substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 21 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1 is independently halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0222] In some embodiments, R 1 is independently R 21 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1 is independently R 21 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1 is independently R 21 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1 is independently R 21 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1 is independently R 21 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1 is independently R 21 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1 is independently an unsubstituted cycloalkyl (e.g., C 3 - C8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1 is independently R 21 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1 is independently R 21 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1 is independently R 21 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1 is independently R 21 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1 is independently R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1 is independently R 21 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0223] In some embodiments, R 1 is independently -CX 1 3 . In some embodiments, R 1 is independently -CHX 1 2. In some embodiments, R 1 is independently -CH 2 X 1 . In some embodiments, R 1 is independently -OCX 1 3. In some embodiments, R 1 is independently -OCH 2 X 1 . In some embodiments, R 1 is independently -OCHX 1 2 . In some embodiments, R 1 is independently -CN. In some embodiments, R 1 is independently -SR 1D . In some embodiments, R 1 is independently -SOR 1D . In some embodiments, R 1 is independently –SO 2 R 1D . In some embodiments, R 1 is independently –SO 3 R 1D . In some embodiments, R 1 is independently –SO 4 R 1D . In some embodiments, R 1 is independently -SONR 1A R 1B . In some embodiments, R 1 is independently –SO 2 NR 1A R 1B . In some embodiments, R 1 is independently -NHC(O)NR 1A R 1B . In some embodiments, R 1 is independently -N(O). In some embodiments, R 1 is independently -N(O) 2 . In some embodiments, R 1 is independently -NR 1A R 1B . In some embodiments, R 1 is independently -C(O)R 1C . In some embodiments, R 1 is independently -C(O)-OR 1C . In some embodiments, R 1 is independently -C(O)NR 1A R 1B . In some embodiments, R 1 is independently -OR 1D . In some embodiments, R 1 is independently -NR 1A SO 2 R 1D . In some embodiments, R 1 is independently -NR 1A C(O)R 1C . In some embodiments, R 1 is independently -NR 1A C(O)OR 1C . In some embodiments, R 1 is independently -NR 1A OR 1C . [0224] In some embodiments, R 1 is independently oxo. In some embodiments, R 1 is independently halogen. In some embodiments, R 1 is independently -CC1 3 . In some embodiments, R 1 is independently -CBr 3 . In some embodiments, R 1 is independently -CF 3 . In some embodiments, R 1 is independently -C1 3 . In some embodiments, R 1 is independently -CHC1 2 . In some embodiments, R 1 is independently -CHBr 2 . In some embodiments, R 1 is independently -CHF 2 . In some embodiments, R 1 is independently -CHI 2 . In some embodiments, R 1 is independently -CH 2 C1. In some embodiments, R 1 is independently -CH 2 Br. In some embodiments, R 1 is independently -CH 2 F. In some embodiments, R 1 is independently -CH 2 I. In some embodiments, R 1 is independently -CN. In some embodiments, R 1 is independently -OH. In some embodiments, R 1 is independently -NH 2 . In some embodiments, R 1 is independently -COOH. In some embodiments, R 1 is independently -CONH 2 . In some embodiments, R 1 is independently -NO 2 . In some embodiments, R 1 is independently -SH. In some embodiments, R 1 is independently -SO 3 H. In some embodiments, R 1 is independently -SO 4 H. In some embodiments, R 1 is independently -SO 2 NH 2 . In some embodiments, R 1 is independently -NHNH 2 . In some embodiments, R 1 is independently -ONH 2 . In some embodiments, R 1 is independently -NHC(O)NHNH 2 . In some embodiments, R 1 is independently -NHC(O)NH 2 . In some embodiments, R 1 is independently -NHSO 2 H. In some embodiments, R 1 is independently -NHC(O)H. In some embodiments, R 1 is independently -NHC(O)OH. In some embodiments, R 1 is independently -NHOH. In some embodiments, R 1 is independently -OCC1 3 . In some embodiments, R 1 is independently -OCF 3 . In some embodiments, R 1 is independently -OCBr 3 . In some embodiments, R 1 is independently -OC1 3 . In some embodiments, R 1 is independently -OCHC1 2 . In some embodiments, R 1 is independently -OCHBr 2 . In some embodiments, R 1 is independently -OCHI 2 . In some embodiments, R 1 is independently -OCHF 2 . In some embodiments, R 1 is independently -OCH 2 C1. In some embodiments, R 1 is independently -OCH 2 Br. In some embodiments, R 1 is independently -OCH 2 I. In some embodiments, R 1 is independently -OCH 2 F. In some embodiments, R 1 is independently -N 3 . In some embodiments, R 1 is independently –OCH 3 . In some embodiments, R 1 is independently –CH 3 . In some embodiments, R 1 is independently –CH 2 CH 3 . In some embodiments, R 1 is independently unsubstituted propyl. In some embodiments, R 1 is independently unsubstituted isopropyl. In some embodiments, R 1 is independently unsubstituted butyl. In some embodiments, R 1 is independently unsubstituted tert-butyl. In some embodiments, R 1 is independently –F. In some embodiments, R 1 is independently –C1. In some embodiments, R 1 is independently –Br. In some embodiments, R 1 is independently –I. [0225] In some embodiments, R 21 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 22 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 22 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 22 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 22 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 22 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 22 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 21 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0226] In some embodiments, R 21 is independently oxo. In some embodiments, R 21 is independently halogen. In some embodiments, R 21 is independently -CC1 3 . In some embodiments, R 21 is independently -CBr 3 . In some embodiments, R 21 is independently -CF 3 . In some embodiments, R 21 is independently -C1 3 . In some embodiments, R 21 is independently -CHC1 2 . In some embodiments, R 21 is independently -CHBr 2 . In some embodiments, R 21 is independently -CHF 2 . In some embodiments, R 21 is independently -CHI 2 . In some embodiments, R 21 is independently -CH 2 C1. In some embodiments, R 21 is independently -CH 2 Br. In some embodiments, R 21 is independently -CH 2 F. In some embodiments, R 21 is independently -CH 2 I. In some embodiments, R 21 is independently -CN. In some embodiments, R 21 is independently -OH. In some embodiments, R 21 is independently -NH 2 . In some embodiments, R 21 is independently -COOH. In some embodiments, R 21 is independently -CONH 2 . In some embodiments, R 21 is independently -NO 2 . In some embodiments, R 21 is independently -SH. In some embodiments, R 21 is independently -SO 3 H. In some embodiments, R 21 is independently -SO 4 H. In some embodiments, R 21 is independently -SO 2 NH 2 . In some embodiments, R 21 is independently -NHNH 2 . In some embodiments, R 21 is independently -ONH 2 . In some embodiments, R 21 is independently -NHC(O)NHNH 2 . In some embodiments, R 21 is independently -NHC(O)NH 2 . In some embodiments, R 21 is independently -NHSO 2 H. In some embodiments, R 21 is independently -NHC(O)H. In some embodiments, R 21 is independently -NHC(O)OH. In some embodiments, R 21 is independently -NHOH. In some embodiments, R 21 is independently -OCC1 3 . In some embodiments, R 21 is independently -OCF 3 . In some embodiments, R 21 is independently -OCBr 3 . In some embodiments, R 21 is independently -OC1 3 . In some embodiments, R 21 is independently -OCHC1 2 . In some embodiments, R 21 is independently -OCHBr 2 . In some embodiments, R 21 is independently -OCHI 2 . In some embodiments, R 21 is independently -OCHF 2 . In some embodiments, R 21 is independently -OCH 2 C1. In some embodiments, R 21 is independently -OCH 2 Br. In some embodiments, R 21 is independently -OCH 2 I. In some embodiments, R 21 is independently -OCH 2 F. In some embodiments, R 21 is independently -N 3 . In some embodiments, R 21 is independently –OCH 3 . In some embodiments, R 21 is independently –CH 3 . In some embodiments, R 21 is independently –CH 2 CH 3 . In some embodiments, R 21 is independently unsubstituted propyl. In some embodiments, R 21 is independently unsubstituted isopropyl. In some embodiments, R 21 is independently unsubstituted butyl. In some embodiments, R 21 is independently unsubstituted tert-butyl. In some embodiments, R 21 is independently –F. In some embodiments, R 21 is independently –C1. In some embodiments, R 21 is independently –Br. In some embodiments, R 21 is independently –I. [0227] In some embodiments, R 21 is independently R 22 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 21 is independently R 22 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 21 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 21 is independently R 22 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 21 is independently R 22 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 21 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 21 is independently R 22 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 21 is independently R 22 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 21 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 21 is independently R 22 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 21 is independently R 22 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 21 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 21 is independently R 22 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 21 is independently R 22 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 21 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 21 is independently R 22 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 21 is independently R 22 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 21 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0228] In some embodiments, R 22 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 23 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 23 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 23 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 23 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 23 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 23 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 22 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0229] In some embodiments, R 22 is independently R 23 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 22 is independently R 23 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 22 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 22 is independently R 23 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 22 is independently R 23 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 22 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 22 is independently R 23 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 22 is independently R 23 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 22 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 22 is independently R 23 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 22 is independently R 23 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 22 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 22 is independently R 23 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 22 is independently R 23 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 22 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 22 is independently R 23 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 22 is independently R 23 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 22 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0230] In some embodiments, R 22 is independently oxo. In some embodiments, R 22 is independently halogen. In some embodiments, R 22 is independently -CC1 3 . In some embodiments, R 22 is independently -CBr 3 . In some embodiments, R 22 is independently -CF 3 . In some embodiments, R 22 is independently -C1 3 . In some embodiments, R 22 is independently CHC1 2 . In some embodiments, R 22 is independently -CHBr 2 . In some embodiments, R 22 is independently -CHF 2 . In some embodiments, R 22 is independently -CHI 2 . In some embodiments, R 22 is independently -CH 2 C1. In some embodiments, R 22 is independently -CH 2 Br. In some embodiments, R 22 is independently -CH 2 F. In some embodiments, R 22 is independently -CH 2 I. In some embodiments, R 22 is independently -CN. In some embodiments, R 22 is independently -OH. In some embodiments, R 22 is independently -NH 2 . In some embodiments, R 22 is independently -COOH. In some embodiments, R 22 is independently -CONH 2 . In some embodiments, R 22 is independently -NO 2 . In some embodiments, R 22 is independently -SH. In some embodiments, R 22 is independently -SO 3 H. In some embodiments, R 22 is independently -SO 4 H. In some embodiments, R 22 is independently -SO 2 NH 2 . In some embodiments, R 22 is independently -NHNH 2 . In some embodiments, R 22 is independently -ONH 2 . In some embodiments, R 22 is independently -NHC(O)NHNH 2 . In some embodiments, R 22 is independently -NHC(O)NH 2 . In some embodiments, R 22 is independently -NHSO 2 H. In some embodiments, R 22 is independently -NHC(O)H. In some embodiments, R 22 is independently -NHC(O)OH. In some embodiments, R 22 is independently -NHOH. In some embodiments, R 22 is independently -OCC1 3 . In some embodiments, R 22 is independently -OCF 3 . In some embodiments, R 22 is independently -OCBr 3 . In some embodiments, R 22 is independently -OC1 3 . In some embodiments, R 22 is independently -OCHC1 2 . In some embodiments, R 22 is independently -OCHBr 2 . In some embodiments, R 22 is independently -OCHI 2 . In some embodiments, R 22 is independently -OCHF 2 . In some embodiments, R 22 is independently -OCH 2 C1. In some embodiments, R 22 is independently -OCH 2 Br. In some embodiments, R 22 is independently -OCH 2 I. In some embodiments, R 22 is independently -OCH 2 F. In some embodiments, R 22 is independently -N 3 . In some embodiments, R 22 is independently –OCH 3 . In some embodiments, R 22 is independently –CH 3 . In some embodiments, R 22 is independently –CH 2 CH 3 . In some embodiments, R 22 is independently unsubstituted propyl. In some embodiments, R 22 is independently unsubstituted isopropyl. In some embodiments, R 22 is independently unsubstituted butyl. In some embodiments, R 22 is independently unsubstituted tert-butyl. In some embodiments, R 22 is independently –F. In some embodiments, R 22 is independently –C1. In some embodiments, R 22 is independently –Br. In some embodiments, R 22 is independently –I. [0231] In some embodiments, R 23 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0232] In some embodiments, R 23 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 23 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 23 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 23 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 23 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 23 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0233] In some embodiments, R 23 is independently oxo. In some embodiments, R 23 is independently halogen. In some embodiments, R 23 is independently -CC1 3 . In some embodiments, R 23 is independently -CBr 3 . In some embodiments, R 23 is independently -CF 3 . In some embodiments, R 23 is independently -C1 3 . In some embodiments, R 23 is independently -CHC1 2 . In some embodiments, R 23 is independently -CHBr 2 . In some embodiments, R 23 is independently -CHF 2 . In some embodiments, R 23 is independently -CHI 2 . In some embodiments, R 23 is independently -CH 2 C1. In some embodiments, R 23 is independently -CH 2 Br. In some embodiments, R 23 is independently -CH 2 F. In some embodiments, R 23 is independently -CH 2 I. In some embodiments, R 23 is independently -CN. In some embodiments, R 23 is independently -OH. In some embodiments, R 23 is independently -NH 2 . In some embodiments, R 23 is independently -COOH. In some embodiments, R 23 is independently -CONH 2 . In some embodiments, R 23 is independently -NO 2 . In some embodiments, R 23 is independently -SH. In some embodiments, R 23 is independently -SO 3 H. In some embodiments, R 23 is independently -SO 4 H. In some embodiments, R 23 is independently -SO 2 NH 2 . In some embodiments, R 23 is independently -NHNH 2 . In some embodiments, R 23 is independently -ONH 2 . In some embodiments, R 23 is independently -NHC(O)NHNH 2 . In some embodiments, R 23 is independently -NHC(O)NH 2 . In some embodiments, R 23 is independently -NHSO 2 H. In some embodiments, R 23 is independently -NHC(O)H. In some embodiments, R 23 is independently -NHC(O)OH. In some embodiments, R 23 is independently -NHOH. In some embodiments, R 23 is independently -OCC1 3 . In some embodiments, R 23 is independently -OCF 3 . In some embodiments, R 23 is independently -OCBr 3 . In some embodiments, R 23 is independently -OC1 3 . In some embodiments, R 23 is independently -OCHC1 2 . In some embodiments, R 23 is independently -OCHBr 2 . In some embodiments, R 23 is independently -OCHI 2 . In some embodiments, R 23 is independently -OCHF 2 . In some embodiments, R 23 is independently -OCH 2 C1. In some embodiments, R 23 is independently -OCH 2 Br. In some embodiments, R 23 is independently -OCH 2 I. In some embodiments, R 23 is independently -OCH 2 F. In some embodiments, R 23 is independently -N 3 . In some embodiments, R 23 is independently –OCH 3 . In some embodiments, R 23 is independently –CH 3 . In some embodiments, R 23 is independently –CH 2 CH 3 . In some embodiments, R 23 is independently unsubstituted propyl. In some embodiments, R 23 is independently unsubstituted isopropyl. In some embodiments, R 23 is independently unsubstituted butyl. In some embodiments, R 23 is independently unsubstituted tert-butyl. In some embodiments, R 23 is independently –F. In some embodiments, R 23 is independently –C1. In some embodiments, R 23 is independently –Br. In some embodiments, R 23 is independently –I. [0234] In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form a substituted or unsubstituted alkylene (e.g., -CH 2 - or -CH 2 CH 2 -), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two R 1 substituents are independently joined to form a substituted or unsubstituted alkylene (e.g., -CH 2 - or -CH 2 CH 2 -). In some embodiments, two adjacent R 1 substituents are independently joined to form a substituted or unsubstituted alkylene (e.g., -CH 2 - or -CH 2 CH 2 -). In some embodiments, two non-adjacent R 1 substituents are independently joined to form a substituted or unsubstituted alkylene (e.g., -CH 2 - or -CH 2 CH 2 -). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form a substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form a substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form a substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form a substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an R 21 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an R 21 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an R 21 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an R 21 - substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an R 21 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an R 21 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an R 21 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 1 substituents are independently joined to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). It is understood that when two R 1 substituents are taken together to form a ring structure (fused or bridged), the two R 1 substituents can be adjacent or non- adjacent. [0235] In some embodiments, one R 1 substituent is taken together with R 2 to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, one R 1 substituent is taken together with R 2 to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, one R 1 substituent is taken together with R 2 to form a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, one R 1 substituent is taken together with R 2 to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, one R 1 substituent is taken together with R 2 to form an R 21 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, one R 1 substituent is taken together with R 2 to form a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, one R 1 substituent is taken together with R 2 to form a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, one R 1 substituent is taken together with R 2 to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, one R 1 substituent is taken together with R 2 to form an R 21 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0236] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1 position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1 position, R 1 is replaced with a divalent linker, referred to in this embodiment as L R1 . [0237] In some embodiments, L R1 is a bond, -S(O) 2 -, -S(O)-, -NR 1A -, =N-, -O-, -S-, -C(O)-, -C(O)NR 1A -, -NR 1A C(O)-, -NR 1A C(O)NH-, -NHC(O)NR 1A -, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. It will be understood that when –L R1 - is =N-, one of the two direct covalent connections to L R1 shown in “-L R1 -” is a double bond and L R1 may equivalently be shown as “=L R1 -” and the atom to which the double bond is directly attached must obey standard rules of chemical valency known in the chemical arts and be capable of forming such a double bond. [0238] In some embodiments, L R1 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R1 is independently a -S(O) 2 -. In some embodiments, L R1 is independently a -S(O)-. In some embodiments, L R1 is independently a -NH-. In some embodiments, L R1 is independently a -O-. In some embodiments, L R1 is independently a -S-. In some embodiments, L R1 is independently a -C(O)-. In some embodiments, L R1 is independently a -C(O)NH-. In some embodiments, L R1 is independently a -NHC(O)-. In some embodiments, L R1 is independently a -NHC(O)NH-. In some embodiments, L R1 is independently a -C(O)O-. In some embodiments, L R1 is independently -OC(O)-. In some embodiments, L R1 is independently -NR 1A -. In some embodiments, L R1 is independently -C(O)NR 1A -. In some embodiments, L R1 is independently -NR 1A C(O)-. In some embodiments, L R1 is independently -NR 1A C(O)NH-. In some embodiments, L R1 is independently -NHC(O)NR 1A -. In some embodiments, L R1 is independently a bond. [0239] In some embodiments, L R1 is substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R1 is substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R1 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R1 is substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R1 is substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R1 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R1 is substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R1 is substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R1 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R1 is substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R1 is substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R1 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R1 is substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R1 is substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R1 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R1 is substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R1 is substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R1 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0240] In some embodiments, L R1 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, R 21 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), R 21 - substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), R 21 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), R 21 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), R 21 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or R 21 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R1 is independently a bond -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0241] In some embodiments, L R1 is R 21 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R1 is R 21 -substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R1 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R1 is R 21 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R1 is R 21 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R1 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R1 is R 21 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R1 is R 21 -substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R1 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R1 is R 21 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R1 is R 21 -substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R1 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R1 is R 21 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R1 is R 21 -substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R1 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R1 is R 21 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R1 is R 21 -substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R1 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0242] In some embodiments, R 1A is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0243] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1A position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1A position, R 1A is replaced with a divalent linker, referred to in this embodiment as L R1 . [0244] In some embodiments, R 1B is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0245] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1B position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1B position, R 1B is replaced with a divalent linker, referred to in this embodiment as L R1 . [0246] In some embodiments, R 1C is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0247] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1C position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1C position, R 1C is replaced with a divalent linker, referred to in this embodiment as L R1 . [0248] In some embodiments, R 1D is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0249] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1D position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 1D position, R 1D is replaced with a divalent linker, referred to in this embodiment as L R1 . [0250] In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0251] In some embodiments, R 1A , R 1B , R 1C , and R 1D are independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , R 21 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 21 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 21 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 21 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 21 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form an R 21 - substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form an R 21 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl. In some embodiments, R 1A and R 1B substituents bonded to the same nitrogen atom are independently joined to form an R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0252] In some embodiments, R 1A is independently R 21 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1A is independently R 21 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1A is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1A is independently R 21 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1A is independently R 21 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1A is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1A is independently R 21 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1A is independently R 21 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1A is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1A is independently R 21 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1A is independently R 21 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1A is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1A is independently R 21 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1A is independently R 21 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1A is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1A is independently R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1A is independently R 21 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1A is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0253] In some embodiments, R 1A is independently -CC1 3 . In some embodiments, R 1A is independently -CBr 3 . In some embodiments, R 1A is independently -CF 3 . In some embodiments, R 1A is independently -C1 3 . In some embodiments, R 1A is independently -CHC1 2 . In some embodiments, R 1A is independently -CHBr 2 . In some embodiments, R 1A is independently -CHF 2 . In some embodiments, R 1A is independently -CHI 2 . In some embodiments, R 1A is independently -CH 2 C1. In some embodiments, R 1A is independently -CH 2 Br. In some embodiments, R 1A is independently -CH 2 F. In some embodiments, R 1A is independently -CH 2 I. In some embodiments, R 1A is independently -CN. In some embodiments, R 1A is independently -OH. In some embodiments, R 1A is independently -COOH. In some embodiments, R 1A is independently -CONH 2 . In some embodiments, R 1A is independently -OCC1 3 . In some embodiments, R 1A is independently -OCF 3 . In some embodiments, R 1A is independently -OCBr 3 . In some embodiments, R 1A is independently -OC1 3 . In some embodiments, R 1A is independently -OCHC1 2 . In some embodiments, R 1A is independently -OCHBr 2 . In some embodiments, R 1A is independently -OCHI 2 . In some embodiments, R 1A is independently -OCHF 2 . In some embodiments, R 1A is independently -OCH 2 C1. In some embodiments, R 1A is independently -OCH 2 Br. In some embodiments, R 1A is independently -OCH 2 I. In some embodiments, R 1A is independently -OCH 2 F. In some embodiments, R 1A is independently –OCH 3 . In some embodiments, R 1A is independently –CH 3 . In some embodiments, R 1A is independently –CH 2 CH 3 . In some embodiments, R 1A is independently unsubstituted propyl. In some embodiments, R 1A is independently unsubstituted isopropyl. In some embodiments, R 1A is independently unsubstituted butyl. In some embodiments, R 1A is independently unsubstituted tert-butyl. In some embodiments, R 1A is independently hydrogen. [0254] In some embodiments, R 1B is independently R 21 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1B is independently R 21 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1B is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1B is independently R 21 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1B is independently R 21 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1B is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1B is independently R 21 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1B is independently R 21 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1B is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1B is independently R 21 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1B is independently R 21 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1B is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1B is independently R 21 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1B is independently R 21 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1B is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1B is independently R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1B is independently R 21 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1B is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0255] In some embodiments, R 1B is independently -CC1 3 . In some embodiments, R 1B is independently -CBr 3 . In some embodiments, R 1B is independently -CF 3 . In some embodiments, R 1B is independently -C1 3 . In some embodiments, R 1B is independently -CHC1 2 . In some embodiments, R 1B is independently -CHBr 2 . In some embodiments, R 1B is independently -CHF 2 . In some embodiments, R 1B is independently -CHI 2 . In some embodiments, R 1B is independently -CH 2 C1. In some embodiments, R 1B is independently -CH 2 Br. In some embodiments, R 1B is independently -CH 2 F. In some embodiments, R 1B is independently -CH 2 I. In some embodiments, R 1B is independently -CN. In some embodiments, R 1B is independently -OH. In some embodiments, R 1B is independently -COOH. In some embodiments, R 1B is independently -CONH 2 . In some embodiments, R 1B is independently -OCC1 3 . In some embodiments, R 1B is independently -OCF 3 . In some embodiments, R 1B is independently -OCBr 3 . In some embodiments, R 1B is independently -OC1 3 . In some embodiments, R 1B is independently -OCHC1 2 . In some embodiments, R 1B is independently -OCHBr 2 . In some embodiments, R 1B is independently -OCHI 2 . In some embodiments, R 1B is independently -OCHF 2 . In some embodiments, R 1B is independently -OCH 2 C1. In some embodiments, R 1B is independently -OCH 2 Br. In some embodiments, R 1B is independently -OCH 2 I. In some embodiments, R 1B is independently -OCH 2 F. In some embodiments, R 1B is independently –OCH 3 . In some embodiments, R 1B is independently – CH 3 . In some embodiments, R 1B is independently –CH 2 CH 3 . In some embodiments, R 1B is independently unsubstituted propyl. In some embodiments, R 1B is independently unsubstituted isopropyl. In some embodiments, R 1B is independently unsubstituted butyl. In some embodiments, R 1B is independently unsubstituted tert-butyl. In some embodiments, R 1B is independently hydrogen. [0256] In some embodiments, R 1C is independently R 21 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1C is independently R 21 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1C is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1C is independently R 21 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1C is independently R 21 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1C is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1C is independently R 21 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1C is independently R 21 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1C is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1C is independently R 21 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1C is independently R 21 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1C is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1C is independently R 21 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1C is independently R 21 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1C is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1C is independently R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1C is independently R 21 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1C is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0257] In some embodiments, R 1C is independently -CC1 3 . In some embodiments, R 1C is independently -CBr 3 . In some embodiments, R 1C is independently -CF 3 . In some embodiments, R 1C is independently -C1 3 . In some embodiments, R 1C is independently -CHC1 2 . In some embodiments, R 1C is independently -CHBr 2 . In some embodiments, R 1C is independently -CHF 2 . In some embodiments, R 1C is independently -CHI 2 . In some embodiments, R 1C is independently -CH 2 C1. In some embodiments, R 1C is independently -CH 2 Br. In some embodiments, R 1C is independently -CH 2 F. In some embodiments, R 1C is independently -CH 2 I. In some embodiments, R 1C is independently -CN. In some embodiments, R 1C is independently -OH. In some embodiments, R 1C is independently -COOH. In some embodiments, R 1C is independently -CONH 2 . In some embodiments, R 1C is independently -OCC1 3 . In some embodiments, R 1C is independently -OCF 3 . In some embodiments, R 1C is independently -OCBr 3 . In some embodiments, R 1C is independently -OC1 3 . In some embodiments, R 1C is independently -OCHC1 2 . In some embodiments, R 1C is independently -OCHBr 2 . In some embodiments, R 1C is independently -OCHI 2 . In some embodiments, R 1C is independently -OCHF 2 . In some embodiments, R 1C is independently -OCH 2 C1. In some embodiments, R 1C is independently -OCH 2 Br. In some embodiments, R 1C is independently -OCH 2 I. In some embodiments, R 1C is independently -OCH 2 F. In some embodiments, R 1C is independently –OCH 3 . In some embodiments, R 1C is independently – CH 3 . In some embodiments, R 1C is independently –CH 2 CH 3 . In some embodiments, R 1C is independently unsubstituted propyl. In some embodiments, R 1C is independently unsubstituted isopropyl. In some embodiments, R 1C is independently unsubstituted butyl. In some embodiments, R 1C is independently unsubstituted tert-butyl. In some embodiments, R 1C is independently hydrogen. [0258] In some embodiments, R 1D is independently R 21 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1D is independently R 21 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1D is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 1D is independently R 21 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1D is independently R 21 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1D is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 1D is independently R 21 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1D is independently R 21 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1D is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 1D is independently R 21 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1D is independently R 21 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1D is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 1D is independently R 21 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1D is independently R 21 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1D is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 1D is independently R 21 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1D is independently R 21 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 1D is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0259] In some embodiments, R 1D is independently -CC1 3 . In some embodiments, R 1D is independently -CBr 3 . In some embodiments, R 1D is independently -CF 3 . In some embodiments, R 1D is independently -C1 3 . In some embodiments, R 1D is independently -CHC1 2 . In some embodiments, R 1D is independently -CHBr 2 . In some embodiments, R 1D is independently -CHF 2 . In some embodiments, R 1D is independently -CHI 2 . In some embodiments, R 1D is independently -CH 2 C1. In some embodiments, R 1D is independently -CH 2 Br. In some embodiments, R 1D is independently -CH 2 F. In some embodiments, R 1D is independently -CH 2 I. In some embodiments, R 1D is independently -CN. In some embodiments, R 1D is independently -OH. In some embodiments, R 1D is independently -COOH. In some embodiments, R 1D is independently -CONH 2 . In some embodiments, R 1D is independently -OCC1 3 . In some embodiments, R 1D is independently -OCF 3 . In some embodiments, R 1D is independently -OCBr 3 . In some embodiments, R 1D is independently -OC1 3 . In some embodiments, R 1D is independently -OCHC1 2 . In some embodiments, R 1D is independently -OCHBr 2 . In some embodiments, R 1D is independently -OCHI 2 . In some embodiments, R 1D is independently -OCHF 2 . In some embodiments, R 1D is independently -OCH 2 C1. In some embodiments, R 1D is independently -OCH 2 Br. In some embodiments, R 1D is independently -OCH 2 I. In some embodiments, R 1D is independently -OCH 2 F. In some embodiments, R 1D is independently –OCH 3 . In some embodiments, R 1D is independently –CH 3 . In some embodiments, R 1D is independently –CH 2 CH 3 . In some embodiments, R 1D is independently unsubstituted propyl. In some embodiments, R 1D is independently unsubstituted isopropyl. In some embodiments, R 1D is independently unsubstituted butyl. In some embodiments, R 1D is independently unsubstituted tert-butyl. In some embodiments, R 1D is independently hydrogen. [0260] In some embodiments, R 2 is independently H, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -N 3 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0261] In some embodiments, R 2 is H. In some embodiments, R 2 is independently substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2 is independently substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2 is independently substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2 is independently substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2 is independently substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2 is independently substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2 is independently substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is independently substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is independently substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2 is independently substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2 is independently substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2 is independently substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0262] In some embodiments, R 2 is independently H, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , R 24 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 24 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 24 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 24 - substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 24 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 24 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2 is independently halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0263] In some embodiments, R 2 is H. In some embodiments, R 2 is independently R 24 - substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2 is independently R 24 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2 is independently R 24 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2 is independently R 24 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2 is independently R 24 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2 is independently R 24 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2 is independently R 24 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is independently R 24 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is independently R 24 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2 is independently R 24 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2 is independently R 24 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2 is independently R 24 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0264] In some embodiments, R 2 is independently -CX 2 3. In some embodiments, R 2 is independently -CHX 2 2 . In some embodiments, R 2 is independently -CH 2 X 2 . In some embodiments, R 2 is independently -OCX 2 3. In some embodiments, R 2 is independently -OCH 2 X 2 . In some embodiments, R 2 is independently -OCHX 2 2 . In some embodiments, R 2 is independently -CN. In some embodiments, R 2 is independently -SR 2D . In some embodiments, R 2 is independently -SOR 2D . In some embodiments, R 2 is independently –SO 2 R 2D . In some embodiments, R 2 is independently –SO 3 R 2D . In some embodiments, R 2 is independently –SO 4 R 2D . In some embodiments, R 2 is independently -SONR 2A R 2B . In some embodiments, R 2 is independently –SO 2 NR 2A R 2B . In some embodiments, R 2 is independently -NHC(O)NR 2A R 2B . In some embodiments, R 2 is independently -N(O). In some embodiments, R 2 is independently -N(O) 2 . In some embodiments, R 2 is independently -NR 2A R 2B . In some embodiments, R 2 is independently -C(O)R 2C . In some embodiments, R 2 is independently -C(O)-OR 2C . In some embodiments, R 2 is independently -C(O)NR 2A R 2B . In some embodiments, R 2 is independently -OR 2D . In some embodiments, R 2 is independently -NR 2A SO 2 R 2D . In some embodiments, R 2 is independently -NR 2A C(O)R 2C . In some embodiments, R 2 is independently -NR 2A C(O)OR 2C . In some embodiments, R 2 is independently -NR 2A OR 2C . [0265] In some embodiments, R 2 is independently oxo. In some embodiments, R 2 is independently halogen. In some embodiments, R 2 is independently -CC1 3 . In some embodiments, R 2 is independently -CBr 3 . In some embodiments, R 2 is independently -CF 3 . In some embodiments, R 2 is independently -C1 3 . In some embodiments, R 2 is independently -CHC1 2 . In some embodiments, R 2 is independently -CHBr 2 . In some embodiments, R 2 is independently -CHF 2 . In some embodiments, R 2 is independently -CHI 2 . In some embodiments, R 2 is independently -CH 2 C1. In some embodiments, R 2 is independently -CH 2 Br. In some embodiments, R 2 is independently -CH 2 F. In some embodiments, R 2 is independently -CH 2 I. In some embodiments, R 2 is independently -CN. In some embodiments, R 2 is independently -OH. In some embodiments, R 2 is independently -NH 2 . In some embodiments, R 2 is independently -COOH. In some embodiments, R 2 is independently -CONH 2 . In some embodiments, R 2 is independently -NO 2 . In some embodiments, R 2 is independently -SH. In some embodiments, R 2 is independently -SO 3 H. In some embodiments, R 2 is independently -SO 4 H. In some embodiments, R 2 is independently -SO 2 NH 2 . In some embodiments, R 2 is independently -NHNH 2 . In some embodiments, R 2 is independently -ONH 2 . In some embodiments, R 2 is independently -NHC(O)NHNH 2 . In some embodiments, R 2 is independently -NHC(O)NH 2 . In some embodiments, R 2 is independently -NHSO 2 H. In some embodiments, R 2 is independently -NHC(O)H. In some embodiments, R 2 is independently -NHC(O)OH. In some embodiments, R 2 is independently -NHOH. In some embodiments, R 2 is independently -OCC1 3 . In some embodiments, R 2 is independently -OCF 3 . In some embodiments, R 2 is independently -OCBr 3 . In some embodiments, R 2 is independently -OC1 3 . In some embodiments, R 2 is independently -OCHC1 2 . In some embodiments, R 2 is independently -OCHBr 2 . In some embodiments, R 2 is independently -OCHI 2 . In some embodiments, R 2 is independently -OCHF 2 . In some embodiments, R 2 is independently -OCH 2 C1. In some embodiments, R 2 is independently -OCH 2 Br. In some embodiments, R 2 is independently -OCH 2 I. In some embodiments, R 2 is independently -OCH 2 F. In some embodiments, R 2 is independently -N 3 . In some embodiments, R 2 is independently –OCH 3 . In some embodiments, R 2 is independently –CH 3 . In some embodiments, R 2 is independently –CH 2 CH 3 . In some embodiments, R 2 is independently unsubstituted propyl. In some embodiments, R 2 is independently unsubstituted isopropyl. In some embodiments, R 2 is independently unsubstituted butyl. In some embodiments, R 2 is independently unsubstituted tert-butyl. In some embodiments, R 2 is independently –F. In some embodiments, R 2 is independently –C1. In some embodiments, R 2 is independently –Br. In some embodiments, R 2 is independently –I. [0266] In some embodiments, R 24 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 25 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 25 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 25 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 25 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 25 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 25 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 24 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0267] In some embodiments, R 24 is independently oxo. In some embodiments, R 24 is independently halogen. In some embodiments, R 24 is independently -CC1 3 . In some embodiments, R 24 is independently -CBr 3 . In some embodiments, R 24 is independently -CF 3 . In some embodiments, R 24 is independently -C1 3 . In some embodiments, R 24 is independently -CHC1 2 . In some embodiments, R 24 is independently -CHBr 2 . In some embodiments R 24 is independently -CHF 2 In some embodiments R 24 is independently -CHI 2 . In some embodiments, R 24 is independently -CH 2 C1. In some embodiments, R 24 is independently -CH 2 Br. In some embodiments, R 24 is independently -CH 2 F. In some embodiments, R 24 is independently -CH 2 I. In some embodiments, R 24 is independently -CN. In some embodiments, R 24 is independently -OH. In some embodiments, R 24 is independently -NH 2 . In some embodiments, R 24 is independently -COOH. In some embodiments, R 24 is independently -CONH 2 . In some embodiments, R 24 is independently -NO 2 . In some embodiments, R 24 is independently -SH. In some embodiments, R 24 is independently -SO 3 H. In some embodiments, R 24 is independently -SO 4 H. In some embodiments, R 24 is independently -SO 2 NH 2 . In some embodiments, R 24 is independently -NHNH 2 . In some embodiments, R 24 is independently -ONH 2 . In some embodiments, R 24 is independently -NHC(O)NHNH 2 . In some embodiments, R 24 is independently -NHC(O)NH 2 . In some embodiments, R 24 is independently -NHSO 2 H. In some embodiments, R 24 is independently -NHC(O)H. In some embodiments, R 24 is independently -NHC(O)OH. In some embodiments, R 24 is independently -NHOH. In some embodiments, R 24 is independently -OCC1 3 . In some embodiments, R 24 is independently -OCF 3 . In some embodiments, R 24 is independently -OCBr 3 . In some embodiments, R 24 is independently -OC1 3 . In some embodiments, R 24 is independently -OCHC1 2 . In some embodiments, R 24 is independently -OCHBr 2 . In some embodiments, R 24 is independently -OCHI 2 . In some embodiments, R 24 is independently -OCHF 2 . In some embodiments, R 24 is independently -OCH 2 C1. In some embodiments, R 24 is independently -OCH 2 Br. In some embodiments, R 24 is independently -OCH 2 I. In some embodiments, R 24 is independently -OCH 2 F. In some embodiments, R 24 is independently -N 3 . In some embodiments, R 24 is independently –OCH 3 . In some embodiments, R 24 is independently –CH 3 . In some embodiments, R 24 is independently –CH 2 CH 3 . In some embodiments, R 24 is independently unsubstituted propyl. In some embodiments, R 24 is independently unsubstituted isopropyl. In some embodiments, R 24 is independently unsubstituted butyl. In some embodiments, R 24 is independently unsubstituted tert-butyl. In some embodiments, R 24 is independently –F. In some embodiments, R 24 is independently –C1. In some embodiments, R 24 is independently –Br. In some embodiments, R 24 is independently –I. [0268] In some embodiments, R 24 is independently R 25 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 24 is independently R 25 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 24 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 24 is independently R 25 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 24 is independently R 25 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 24 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 24 is independently R 25 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 24 is independently R 25 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 24 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 24 is independently R 25 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 24 is independently R 25 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 24 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 24 is independently R 25 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 24 is independently R 25 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 24 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 24 is independently R 25 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 24 is independently R 25 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 24 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0269] In some embodiments, R 25 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 26 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 26 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 26 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 26 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 26 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 26 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 25 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0270] In some embodiments, R 25 is independently R 26 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 25 is independently R 26 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 25 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 25 is independently R 26 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 25 is independently R 26 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 25 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 25 is independently R 26 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 25 is independently R 26 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 25 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 25 is independently R 26 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 25 is independently R 26 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 25 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 25 is independently R 26 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 25 is independently R 26 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 25 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 25 is independently R 26 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 25 is independently R 26 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 25 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0271] In some embodiments, R 25 is independently oxo. In some embodiments, R 25 is independently halogen. In some embodiments, R 25 is independently -CC1 3 . In some embodiments, R 25 is independently -CBr 3 . In some embodiments, R 25 is independently -CF 3 . In some embodiments, R 25 is independently -C1 3 . In some embodiments, R 25 is independently -CHC1 2 . In some embodiments, R 25 is independently -CHBr 2 . In some embodiments, R 25 is independently -CHF 2 . In some embodiments, R 25 is independently -CHI 2 . In some embodiments, R 25 is independently -CH 2 C1. In some embodiments, R 25 is independently -CH 2 Br. In some embodiments, R 25 is independently -CH 2 F. In some embodiments, R 25 is independently -CH 2 I. In some embodiments, R 25 is independently -CN. In some embodiments, R 25 is independently -OH. In some embodiments, R 25 is independently -NH 2 . In some embodiments, R 25 is independently -COOH. In some embodiments, R 25 is independently -CONH 2 . In some embodiments, R 25 is independently -NO 2 . In some embodiments, R 25 is independently -SH. In some embodiments, R 25 is independently -SO 3 H. In some embodiments, R 25 is independently -SO 4 H. In some embodiments, R 25 is independently -SO 2 NH 2 . In some embodiments, R 25 is independently -NHNH 2 . In some embodiments, R 25 is independently -ONH 2 . In some embodiments, R 25 is independently -NHC(O)NHNH 2 . In some embodiments, R 25 is independently -NHC(O)NH 2 . In some embodiments, R 25 is independently -NHSO 2 H. In some embodiments, R 25 is independently -NHC(O)H. In some embodiments, R 25 is independently -NHC(O)OH. In some embodiments, R 25 is independently -NHOH. In some embodiments, R 25 is independently -OCC1 3 . In some embodiments, R 25 is independently -OCF 3 . In some embodiments, R 25 is independently -OCBr 3 . In some embodiments, R 25 is independently -OC1 3 . In some embodiments, R 25 is independently -OCHC1 2 . In some embodiments, R 25 is independently -OCHBr 2 . In some embodiments, R 25 is independently -OCHI 2 . In some embodiments, R 25 is independently -OCHF 2 . In some embodiments, R 25 is independently -OCH 2 C1. In some embodiments, R 25 is independently -OCH 2 Br. In some embodiments, R 25 is independently -OCH 2 I. In some embodiments, R 25 is independently -OCH 2 F. In some embodiments, R 25 is independently -N 3 . In some embodiments, R 25 is independently –OCH 3 . In some embodiments, R 25 is independently –CH 3 . In some embodiments, R 25 is independently –CH 2 CH 3 . In some embodiments, R 25 is independently unsubstituted propyl. In some embodiments, R 25 is independently unsubstituted isopropyl. In some embodiments, R 25 is independently unsubstituted butyl. In some embodiments, R 25 is independently unsubstituted tert-butyl. In some embodiments, R 25 is independently –F. In some embodiments, R 25 is independently –C1. In some embodiments, R 25 is independently –Br. In some embodiments, R 25 is independently –I. [0272] In some embodiments, R 26 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0273] In some embodiments, R 26 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 26 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 26 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 26 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 26 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 26 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0274] In some embodiments, R 26 is independently oxo. In some embodiments, R 26 is independently halogen. In some embodiments, R 26 is independently -CC1 3 . In some embodiments, R 26 is independently -CBr 3 . In some embodiments, R 26 is independently -CF 3 . In some embodiments, R 26 is independently -C1 3 . In some embodiments, R 26 is independently -CHC1 2 . In some embodiments, R 26 is independently -CHBr 2 . In some embodiments, R 26 is independently -CHF 2 . In some embodiments, R 26 is independently -CHI 2 . In some embodiments, R 26 is independently -CH 2 C1. In some embodiments, R 26 is independently -CH 2 Br. In some embodiments, R 26 is independently -CH 2 F. In some embodiments, R 26 is independently -CH 2 I. In some embodiments, R 26 is independently -CN. In some embodiments, R 26 is independently -OH. In some embodiments, R 26 is independently -NH 2 . In some embodiments, R 26 is independently -COOH. In some embodiments, R 26 is independently -CONH 2 . In some embodiments, R 26 is independently -NO 2 . In some embodiments, R 26 is independently -SH. In some embodiments, R 26 is independently -SO 3 H. In some embodiments, R 26 is independently -SO 4 H. In some embodiments, R 26 is independently -SO 2 NH 2 . In some embodiments, R 26 is independently -NHNH 2 . In some embodiments, R 26 is independently -ONH 2 . In some embodiments, R 26 is independently -NHC(O)NHNH 2 . In some embodiments, R 26 is independently -NHC(O)NH 2 . In some embodiments, R 26 is independently -NHSO 2 H. In some embodiments, R 26 is independently -NHC(O)H. In some embodiments, R 26 is independently -NHC(O)OH. In some embodiments, R 26 is independently -NHOH. In some embodiments, R 26 is independently -OCC1 3 . In some embodiments, R 26 is independently -OCF 3 . In some embodiments, R 26 is independently -OCBr 3 . In some embodiments, R 26 is independently -OC1 3 . In some embodiments, R 26 is independently -OCHC1 2 . In some embodiments, R 26 is independently -OCHBr 2 . In some embodiments, R 26 is independently -OCHI 2 . In some embodiments, R 26 is independently -OCHF 2 . In some embodiments, R 26 is independently -OCH 2 C1. In some embodiments, R 26 is independently -OCH 2 Br. In some embodiments, R 26 is independently -OCH 2 I. In some embodiments, R 26 is independently -OCH 2 F. In some embodiments, R 26 is independently -N 3 . In some embodiments, R 26 is independently –OCH 3 . In some embodiments, R 26 is independently –CH 3 . In some embodiments, R 26 is independently –CH 2 CH 3 . In some embodiments, R 26 is independently unsubstituted propyl. In some embodiments, R 26 is independently unsubstituted isopropyl. In some embodiments, R 26 is independently unsubstituted butyl. In some embodiments, R 26 is independently unsubstituted tert-butyl. In some embodiments, R 26 is independently –F. In some embodiments, R 26 is independently –C1. In some embodiments, R 26 is independently –Br. In some embodiments, R 26 is independently –I. [0275] In some embodiments, R 2 is taken together with one R 1 substituent to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2 is taken together with one R 1 substituent to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is taken together with one R 1 substituent to form a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is taken together with one R 1 substituent to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is taken together with one R 1 substituent to form an R 21 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2 is taken together with one R 1 substituent to form a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2 is taken together with one R 1 substituent to form a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2 is taken together with one R 1 substituent to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2 is taken together with one R 1 substituent to form an R 21 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0276] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2 position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2 position, R 2 is replaced with a divalent linker, referred to in this embodiment as L R2 . [0277] In some embodiments, L R2 is a bond, -S(O) 2 -, -S(O)-, -NR 2A -, =N-, -O-, -S-, -C(O)-, C(O)NR 2A -, -NR 2A C(O)-, -NR 2A C(O)NH-, -NHC(O)NR 2A -, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. It will be understood that when –L R2 - is =N-, one of the two direct covalent connections to L R2 shown in “-L R2 -” is a double bond and L R2 may equivalently be shown as “=L R2 -” and the atom to which the double bond is directly attached must obey standard rules of chemical valency known in the chemical arts and be capable of forming such a double bond. [0278] In some embodiments, L R2 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R2 is independently a -S(O) 2 -. In some embodiments, L R2 is independently a -S(O)-. In some embodiments, L R2 is independently a -NH-. In some embodiments, L R2 is independently a -O-. In some embodiments, L R2 is independently a -S-. In some embodiments, L R2 is independently a -C(O)-. In some embodiments, L R2 is independently a -C(O)NH-. In some embodiments, L R2 is independently a -NHC(O)-. In some embodiments, L R2 is independently a -NHC(O)NH-. In some embodiments, L R2 is independently a -C(O)O-. In some embodiments, L R2 is independently -OC(O)-. In some embodiments, L R2 is independently – NR 2A -. In some embodiments, L R2 is independently -C(O)NR 2A -. In some embodiments, L R2 is independently –NR 2A C(O)-. In some embodiments, L R2 is independently –NR 2A C(O)NH-. In some embodiments, L R2 is independently -NHC(O)NR 2A -. In some embodiments, L R2 is independently a bond. [0279] In some embodiments, L R2 is substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R2 is substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R2 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R2 is substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R2 is substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R2 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R2 is substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R2 is substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R2 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R2 is substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R2 is substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R2 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R2 is substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R2 is substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R2 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R2 is substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R2 is substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R2 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0280] In some embodiments, L R2 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, R 24 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), R 24 - substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), R 24 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), R 24 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), R 24 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or R 24 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R2 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0281] In some embodiments, L R2 is R 24 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R2 is R 24 -substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R2 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R2 is R 24 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R2 is R 24 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R2 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R2 is R 24 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R2 is R 24 -substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R2 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R2 is R 24 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R2 is R 24 -substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R2 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R2 is R 24 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R2 is R 24 -substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R2 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R2 is R 24 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R2 is R 24 -substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R2 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0282] In some embodiments, R 2A is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0283] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2A position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2A position, R 2A is replaced with a divalent linker, referred to in this embodiment as L R2 . [0284] In some embodiments, R 2B is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0285] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2B position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2B position, R 2B is replaced with a divalent linker, referred to in this embodiment as L R2 . [0286] In some embodiments, R 2C is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0287] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2C position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2C position, R 2C is replaced with a divalent linker, referred to in this embodiment as L R2 . [0288] In some embodiments, R 2D is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0289] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2D position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 2D position, R 2D is replaced with a divalent linker, referred to in this embodiment as L R2 . [0290] In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0291] In some embodiments, R 2A , R 2B , R 2C , and R 2D are independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , R 24 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 24 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 24 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 24 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 24 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 24 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form an R 24 - substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or R 24 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form an R 24 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl. In some embodiments, R 2A and R 2B substituents bonded to the same nitrogen atom are independently joined to form an R 24 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0292] In some embodiments, R 2A is independently R 24 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2A is independently R 24 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2A is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2A is independently R 24 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2A is independently R 24 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2A is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2A is independently R 24 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2A is independently R 24 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2A is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2A is independently R 24 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2A is independently R 24 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2A is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2A is independently R 24 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2A is independently R 24 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2A is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2A is independently R 24 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2A is independently R 24 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2A is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0293] In some embodiments, R 2A is independently -CC1 3 . In some embodiments, R 2A is independently -CBr 3 . In some embodiments, R 2A is independently -CF 3 . In some embodiments, R 2A is independently -C1 3 . In some embodiments, R 2A is independently -CHC1 2 . In some embodiments, R 2A is independently -CHBr 2 . In some embodiments, R 2A is independently -CHF 2 . In some embodiments, R 2A is independently -CHI 2 . In some embodiments, R 2A is independently -CH 2 C1. In some embodiments, R 2A is independently -CH 2 Br. In some embodiments, R 2A is independently -CH 2 F. In some embodiments, R 2A is independently -CH 2 I. In some embodiments, R 2A is independently -CN. In some embodiments, R 2A is independently -OH. In some embodiments, R 2A is independently -COOH. In some embodiments, R 2A is independently -CONH 2 . In some embodiments, R 2A is independently -OCC1 3 . In some embodiments, R 2A is independently -OCF 3 . In some embodiments, R 2A is independently -OCBr 3 . In some embodiments, R 2A is independently -OC1 3 . In some embodiments, R 2A is independently -OCHC1 2 . In some embodiments, R 2A is independently -OCHBr 2 . In some embodiments, R 2A is independently -OCHI 2 . In some embodiments, R 2A is independently -OCHF 2 . In some embodiments, R 2A is independently -OCH 2 C1. In some embodiments, R 2A is independently -OCH 2 Br. In some embodiments, R 2A is independently -OCH 2 I. In some embodiments, R 2A is independently -OCH 2 F. In some embodiments, R 2A is independently –OCH 3 . In some embodiments, R 2A is independently –CH 3 . In some embodiments, R 2A is independently –CH 2 CH 3 . In some embodiments, R 2A is independently unsubstituted propyl. In some embodiments, R 2A is independently unsubstituted isopropyl. In some embodiments, R 2A is independently unsubstituted butyl. In some embodiments, R 2A is independently unsubstituted tert-butyl. In some embodiments, R 2A is independently hydrogen. [0294] In some embodiments, R 2B is independently R 24 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2B is independently R 24 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2B is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2B is independently R 24 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2B is independently R 24 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2B is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2B is independently R 24 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2B is independently R 24 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2B is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2B is independently R 24 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2B is independently R 24 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2B is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2B is independently R 24 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2B is independently R 24 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2B is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2B is independently R 24 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2B is independently R 24 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2B is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0295] In some embodiments, R 2B is independently -CC1 3 . In some embodiments, R 2B is independently -CBr 3 . In some embodiments, R 2B is independently -CF 3 . In some embodiments, R 2B is independently -C1 3 . In some embodiments, R 2B is independently -CHC1 2 . In some embodiments, R 2B is independently -CHBr 2 . In some embodiments, R 2B is independently -CHF 2 . In some embodiments, R 2B is independently -CHI 2 . In some embodiments, R 2B is independently -CH 2 C1. In some embodiments, R 2B is independently -CH 2 Br. In some embodiments, R 2B is independently -CH 2 F. In some embodiments, R 2B is independently -CH 2 I. In some embodiments, R 2B is independently -CN. In some embodiments, R 2B is independently -OH. In some embodiments, R 2B is independently -COOH. In some embodiments, R 2B is independently -CONH 2 . In some embodiments, R 2B is independently -OCC1 3 . In some embodiments, R 2B is independently -OCF 3 . In some embodiments, R 2B is independently -OCBr 3 . In some embodiments, R 2B is independently -OC1 3 . In some embodiments, R 2B is independently -OCHC1 2 . In some embodiments, R 2B is independently -OCHBr 2 . In some embodiments, R 2B is independently -OCHI 2 . In some embodiments, R 2B is independently -OCHF 2 . In some embodiments, R 2B is independently -OCH 2 C1. In some embodiments, R 2B is independently -OCH 2 Br. In some embodiments, R 2B is independently -OCH 2 I. In some embodiments, R 2B is independently -OCH 2 F. In some embodiments, R 2B is independently –OCH 3 . In some embodiments, R 2B is independently –CH 3 . In some embodiments, R 2B is independently –CH 2 CH 3 . In some embodiments, R 2B is independently unsubstituted propyl. In some embodiments, R 2B is independently unsubstituted isopropyl. In some embodiments, R 2B is independently unsubstituted butyl. In some embodiments, R 2B is independently unsubstituted tert-butyl. In some embodiments, R 2B is independently hydrogen. [0296] In some embodiments, R 2C is independently R 24 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2C is independently R 24 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2C is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2C is independently R 24 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2C is independently R 24 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2C is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2C is independently R 24 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2C is independently R 24 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2C is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2C is independently R 24 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2C is independently R 24 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2C is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2C is independently R 24 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2C is independently R 24 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2C is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2C is independently R 24 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2C is independently R 24 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2C is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0297] In some embodiments, R 2C is independently -CC1 3 . In some embodiments, R 2C is independently -CBr 3 . In some embodiments, R 2C is independently -CF 3 . In some embodiments, R 2C is independently -C1 3 . In some embodiments, R 2C is independently -CHC1 2 . In some embodiments, R 2C is independently -CHBr 2 . In some embodiments, R 2C is independently -CHF 2 . In some embodiments, R 2C is independently -CHI 2 . In some embodiments, R 2C is independently -CH 2 C1. In some embodiments, R 2C is independently -CH 2 Br. In some embodiments, R 2C is independently -CH 2 F. In some embodiments, R 2C is independently -CH 2 I. In some embodiments, R 2C is independently -CN. In some embodiments, R 2C is independently -OH. In some embodiments, R 2C is independently -COOH. In some embodiments, R 2C is independently -CONH 2 . In some embodiments, R 2C is independently -OCC1 3 . In some embodiments, R 2C is independently -OCF 3 . In some embodiments, R 2C is independently -OCBr 3 . In some embodiments, R 2C is independently -OC1 3 . In some embodiments, R 2C is independently -OCHC1 2 . In some embodiments, R 2C is independently -OCHBr 2 . In some embodiments, R 2C is independently -OCHI 2 . In some embodiments, R 2C is independently -OCHF 2 . In some embodiments, R 2C is independently -OCH 2 C1. In some embodiments, R 2C is independently -OCH 2 Br. In some embodiments, R 2C is independently -OCH 2 I. In some embodiments, R 2C is independently -OCH 2 F. In some embodiments, R 2C is independently –OCH 3 . In some embodiments, R 2C is independently – CH 3 . In some embodiments, R 2C is independently –CH 2 CH 3 . In some embodiments, R 2C is independently unsubstituted propyl. In some embodiments, R 2C is independently unsubstituted isopropyl. In some embodiments, R 2C is independently unsubstituted butyl. In some embodiments, R 2C is independently unsubstituted tert-butyl. In some embodiments, R 2C is independently hydrogen. [0298] In some embodiments, R 2D is independently R 24 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2D is independently R 24 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2D is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 2D is independently R 24 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2D is independently R 24 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2D is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 2D is independently R 24 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2D is independently R 24 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2D is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 2D is independently R 24 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2D is independently R 24 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2D is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 2D is independently R 24 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2D is independently R 24 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2D is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 2D is independently R 24 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2D is independently R 24 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 2D is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0299] In some embodiments, R 2D is independently -CC1 3 . In some embodiments, R 2D is independently -CBr 3 . In some embodiments, R 2D is independently -CF 3 . In some embodiments, R 2D is independently -C1 3 . In some embodiments, R 2D is independently -CHC1 2 . In some embodiments, R 2D is independently -CHBr 2 . In some embodiments, R 2D is independently -CHF 2 . In some embodiments, R 2D is independently -CHI 2 . In some embodiments, R 2D is independently -CH 2 C1. In some embodiments, R 2D is independently -CH 2 Br. In some embodiments, R 2D is independently -CH 2 F. In some embodiments, R 2D is independently -CH 2 I. In some embodiments, R 2D is independently -CN. In some embodiments, R 2D is independently -OH. In some embodiments, R 2D is independently -COOH. In some embodiments, R 2D is independently -CONH 2 . In some embodiments, R 2D is independently -OCC1 3 . In some embodiments, R 2D is independently -OCF 3 . In some embodiments, R 2D is independently -OCBr 3 . In some embodiments, R 2D is independently -OC1 3 . In some embodiments, R 2D is independently -OCHC1 2 . In some embodiments, R 2D is independently -OCHBr 2 . In some embodiments, R 2D is independently -OCHI 2 . In some embodiments, R 2D is independently -OCHF 2 . In some embodiments, R 2D is independently -OCH 2 C1. In some embodiments, R 2D is independently -OCH 2 Br. In some embodiments, R 2D is independently -OCH 2 I. In some embodiments, R 2D is independently -OCH 2 F. In some embodiments, R 2D is independently –OCH 3 . In some embodiments, R 2D is independently – CH 3 . In some embodiments, R 2D is independently –CH 2 CH 3 . In some embodiments, R 2D is independently unsubstituted propyl. In some embodiments, R 2D is independently unsubstituted isopropyl. In some embodiments, R 2D is independently unsubstituted butyl. In some embodiments, R 2D is independently unsubstituted tert-butyl. In some embodiments, R 2D is independently hydrogen. [0300] In some embodiments, R 3 is independently halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -N 3 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0301] In some embodiments, R 3 is independently substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3 is independently substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3 is independently substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3 is independently substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3 is independently substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3 is independently substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3 is independently an unsubstituted cycloalkyl (e.g., C3- C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3 is independently substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3 is independently substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3 is independently substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3 is independently substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3 is independently substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3 is independently substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0302] In some embodiments, R 3 is independently halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , R 27 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 27 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 27 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 27 - substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 27 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3 is independently halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0303] In some embodiments, R 3 is independently R 27 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3 is independently R 27 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3 is independently R 27 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3 is independently R 27 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3 is independently R 27 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3 is independently R 27 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3 is independently an unsubstituted cycloalkyl (e.g., C3- C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3 is independently R 27 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3 is independently R 27 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3 is independently R 27 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3 is independently R 27 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3 is independently R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3 is independently R 27 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0304] In some embodiments, R 3 is independently -CX 3 3 . In some embodiments, R 3 is independently -CHX 3 2. In some embodiments, R 3 is independently -CH 2 X 3 . In some embodiments, R 3 is independently -OCX 3 3 . In some embodiments, R 3 is independently -OCH 2 X 3 . In some embodiments, R 3 is independently -OCHX 3 2. In some embodiments, R 3 is independently -CN. In some embodiments, R 3 is independently -SR 3D . In some embodiments, R 3 is independently -SOR 3D . In some embodiments, R 3 is independently –SO 2 R 3D . In some embodiments, R 3 is independently –SO 3 R 3D . In some embodiments, R 3 is independently –SO 4 R 3D . In some embodiments, R 3 is independently -SONR 3A R 3B . In some embodiments, R 3 is independently –SO 2 NR 3A R 3B . In some embodiments, R 3 is independently -NHC(O)NR 3A R 3B . In some embodiments, R 3 is independently -N(O). In some embodiments, R 3 is independently -N(O) 2 . In some embodiments, R 3 is independently -NR 3A R 3B . In some embodiments, R 3 is independently -C(O)R 3C . In some embodiments, R 3 is independently -C(O)-OR 3C . In some embodiments, R 3 is independently -C(O)NR 3A R 3B . In some embodiments, R 3 is independently -OR 3D . In some embodiments, R 3 is independently -NR 3A SO 2 R 3D . In some embodiments, R 3 is independently -NR 3A C(O)R 3C . In some embodiments, R 3 is independently -NR 3A C(O)OR 3C . In some embodiments, R 3 is independently -NR 3A OR 3C . [0305] In some embodiments, R 3 is independently oxo. In some embodiments, R 3 is independently halogen. In some embodiments, R 3 is independently -CC1 3 . In some embodiments, R 3 is independently -CBr 3 . In some embodiments, R 3 is independently -CF 3 . In some embodiments, R 3 is independently -C1 3 . In some embodiments, R 3 is independently -CHC1 2 . In some embodiments, R 3 is independently -CHBr 2 . In some embodiments, R 3 is independently -CHF 2 . In some embodiments, R 3 is independently -CHI 2 . In some embodiments, R 3 is independently -CH 2 C1. In some embodiments, R 3 is independently -CH 2 Br. In some embodiments, R 3 is independently -CH 2 F. In some embodiments, R 3 is independently -CH 2 I. In some embodiments, R 3 is independently -CN. In some embodiments, R 3 is independently -OH. In some embodiments, R 3 is independently -NH 2 . In some embodiments, R 3 is independently -COOH. In some embodiments, R 3 is independently -CONH 2 . In some embodiments, R 3 is independently -NO 2 . In some embodiments, R 3 is independently -SH. In some embodiments, R 3 is independently -SO 3 H. In some embodiments, R 3 is independently -SO 4 H. In some embodiments, R 3 is independently -SO 2 NH 2 . In some embodiments, R 3 is independently -NHNH 2 . In some embodiments, R 3 is independently -ONH 2 . In some embodiments, R 3 is independently -NHC(O)NHNH 2 . In some embodiments, R 3 is independently -NHC(O)NH 2 . In some embodiments, R 3 is independently -NHSO 2 H. In some embodiments, R 3 is independently -NHC(O)H. In some embodiments, R 3 is independently -NHC(O)OH. In some embodiments, R 3 is independently -NHOH. In some embodiments, R 3 is independently -OCC1 3 . In some embodiments, R 3 is independently -OCF 3 . In some embodiments, R 3 is independently -OCBr 3 . In some embodiments, R 3 is independently -OC1 3 . In some embodiments, R 3 is independently -OCHC1 2 . In some embodiments, R 3 is independently -OCHBr 2 . In some embodiments, R 3 is independently -OCHI 2 . In some embodiments, R 3 is independently -OCHF 2 . In some embodiments, R 3 is independently -OCH 2 C1. In some embodiments, R 3 is independently -OCH 2 Br. In some embodiments, R 3 is independently -OCH 2 I. In some embodiments, R 3 is independently -OCH 2 F. In some embodiments, R 3 is independently -N 3 . In some embodiments, R 3 is independently –OCH 3 . In some embodiments, R 3 is independently –CH 3 . In some embodiments, R 3 is independently –CH 2 CH 3 . In some embodiments, R 3 is independently unsubstituted propyl. In some embodiments, R 3 is independently unsubstituted isopropyl. In some embodiments, R 3 is independently unsubstituted butyl. In some embodiments, R 3 is independently unsubstituted tert-butyl. In some embodiments, R 3 is independently –F. In some embodiments, R 3 is independently –C1. In some embodiments, R 3 is independently –Br. In some embodiments, R 3 is independently –I. [0306] In some embodiments, R 27 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 28 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 28 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 28 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 28 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 28 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 28 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 27 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0307] In some embodiments, R 27 is independently oxo. In some embodiments, R 27 is independently halogen. In some embodiments, R 27 is independently -CC1 3 . In some embodiments, R 27 is independently -CBr 3 . In some embodiments, R 27 is independently -CF 3 . In some embodiments, R 27 is independently -C1 3 . In some embodiments, R 27 is independently -CHC1 2 . In some embodiments, R 27 is independently -CHBr 2 . In some embodiments R 27 is independently -CHF 2 In some embodiments R 27 is independently -CHI 2 . In some embodiments, R 27 is independently -CH 2 C1. In some embodiments, R 27 is independently -CH 2 Br. In some embodiments, R 27 is independently -CH 2 F. In some embodiments, R 27 is independently -CH 2 I. In some embodiments, R 27 is independently -CN. In some embodiments, R 27 is independently -OH. In some embodiments, R 27 is independently -NH 2 . In some embodiments, R 27 is independently -COOH. In some embodiments, R 27 is independently -CONH 2 . In some embodiments, R 27 is independently -NO 2 . In some embodiments, R 27 is independently -SH. In some embodiments, R 27 is independently -SO 3 H. In some embodiments, R 27 is independently -SO 4 H. In some embodiments, R 27 is independently -SO 2 NH 2 . In some embodiments, R 27 is independently -NHNH 2 . In some embodiments, R 27 is independently -ONH 2 . In some embodiments, R 27 is independently -NHC(O)NHNH 2 . In some embodiments, R 27 is independently -NHC(O)NH 2 . In some embodiments, R 27 is independently -NHSO 2 H. In some embodiments, R 27 is independently -NHC(O)H. In some embodiments, R 27 is independently -NHC(O)OH. In some embodiments, R 27 is independently -NHOH. In some embodiments, R 27 is independently -OCC1 3 . In some embodiments, R 27 is independently -OCF 3 . In some embodiments, R 27 is independently -OCBr 3 . In some embodiments, R 27 is independently -OC1 3 . In some embodiments, R 27 is independently -OCHC1 2 . In some embodiments, R 27 is independently -OCHBr 2 . In some embodiments, R 27 is independently -OCHI 2 . In some embodiments, R 27 is independently -OCHF 2 . In some embodiments, R 27 is independently -OCH 2 C1. In some embodiments, R 27 is independently -OCH 2 Br. In some embodiments, R 27 is independently -OCH 2 I. In some embodiments, R 27 is independently -OCH 2 F. In some embodiments, R 27 is independently -N 3 . In some embodiments, R 27 is independently –OCH 3 . In some embodiments, R 27 is independently –CH 3 . In some embodiments, R 27 is independently –CH 2 CH 3 . In some embodiments, R 27 is independently unsubstituted propyl. In some embodiments, R 27 is independently unsubstituted isopropyl. In some embodiments, R 27 is independently unsubstituted butyl. In some embodiments, R 27 is independently unsubstituted tert-butyl. In some embodiments, R 27 is independently –F. In some embodiments, R 27 is independently –C1. In some embodiments, R 27 is independently –Br. In some embodiments, R 27 is independently –I. [0308] In some embodiments, R 27 is independently R 28 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 27 is independently R 28 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 27 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 27 is independently R 28 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 27 is independently R 28 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 27 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 27 is independently R 28 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 27 is independently R 28 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 27 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 27 is independently R 28 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 27 is independently R 28 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 27 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 27 is independently R 28 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 27 is independently R 28 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 27 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 27 is independently R 28 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 27 is independently R 28 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 27 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0309] In some embodiments, R 28 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 29 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 29 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 29 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 29 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 29 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 29 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 28 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0310] In some embodiments, R 28 is independently R 29 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 28 is independently R 29 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 28 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 28 is independently R 29 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 28 is independently R 29 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 28 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 28 is independently R 29 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 28 is independently R 29 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 28 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 28 is independently R 29 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 28 is independently R 29 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 28 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 28 is independently R 29 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 28 is independently R 29 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 28 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 28 is independently R 29 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 28 is independently R 29 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 28 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0311] In some embodiments, R 28 is independently oxo. In some embodiments, R 28 is independently halogen. In some embodiments, R 28 is independently -CC1 3 . In some embodiments, R 28 is independently -CBr 3 . In some embodiments, R 28 is independently -CF 3 . In some embodiments, R 28 is independently -C1 3 . In some embodiments, R 28 is independently -CHC1 2 . In some embodiments, R 28 is independently -CHBr 2 . In some embodiments, R 28 is independently -CHF 2 . In some embodiments, R 28 is independently -CHI 2 . In some embodiments, R 28 is independently -CH 2 C1. In some embodiments, R 28 is independently -CH 2 Br. In some embodiments, R 28 is independently -CH 2 F. In some embodiments, R 28 is independently -CH 2 I. In some embodiments, R 28 is independently -CN. In some embodiments, R 28 is independently -OH. In some embodiments, R 28 is independently -NH 2 . In some embodiments, R 28 is independently -COOH. In some embodiments, R 28 is independently -CONH 2 . In some embodiments, R 28 is independently -NO 2 . In some embodiments, R 28 is independently -SH. In some embodiments, R 28 is independently -SO 3 H. In some embodiments, R 28 is independently -SO 4 H. In some embodiments, R 28 is independently -SO 2 NH 2 . In some embodiments, R 28 is independently -NHNH 2 . In some embodiments, R 28 is independently -ONH 2 . In some embodiments, R 28 is independently -NHC(O)NHNH 2 . In some embodiments, R 28 is independently -NHC(O)NH 2 . In some embodiments, R 28 is independently -NHSO 2 H. In some embodiments, R 28 is independently -NHC(O)H. In some embodiments, R 28 is independently -NHC(O)OH. In some embodiments, R 28 is independently -NHOH. In some embodiments, R 28 is independently -OCC1 3 . In some embodiments, R 28 is independently -OCF 3 . In some embodiments, R 28 is independently -OCBr 3 . In some embodiments, R 28 is independently -OC1 3 . In some embodiments, R 28 is independently -OCHC1 2 . In some embodiments, R 28 is independently -OCHBr 2 . In some embodiments, R 28 is independently -OCHI 2 . In some embodiments, R 28 is independently -OCHF 2 . In some embodiments, R 28 is independently -OCH 2 C1. In some embodiments, R 28 is independently -OCH 2 Br. In some embodiments, R 28 is independently -OCH 2 I. In some embodiments, R 28 is independently -OCH 2 F. In some embodiments, R 28 is independently -N 3 . In some embodiments, R 28 is independently –OCH 3 . In some embodiments, R 28 is independently –CH 3 . In some embodiments, R 28 is independently –CH 2 CH 3 . In some embodiments, R 28 is independently unsubstituted propyl. In some embodiments, R 28 is independently unsubstituted isopropyl. In some embodiments, R 28 is independently unsubstituted butyl. In some embodiments, R 28 is independently unsubstituted tert-butyl. In some embodiments, R 28 is independently –F. In some embodiments, R 28 is independently –C1. In some embodiments, R 28 is independently –Br. In some embodiments, R 28 is independently –I. [0312] In some embodiments, R 29 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0313] In some embodiments, R 29 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 29 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 29 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 29 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 29 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 29 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0314] In some embodiments, R 29 is independently oxo. In some embodiments, R 29 is independently halogen. In some embodiments, R 29 is independently -CC1 3 . In some embodiments, R 29 is independently -CBr 3 . In some embodiments, R 29 is independently -CF 3 . In some embodiments, R 29 is independently -C1 3 . In some embodiments, R 29 is independently -CHC1 2 . In some embodiments, R 29 is independently -CHBr 2 . In some embodiments, R 29 is independently -CHF 2 . In some embodiments, R 29 is independently -CHI 2 . In some embodiments, R 29 is independently -CH 2 C1. In some embodiments, R 29 is independently -CH 2 Br. In some embodiments, R 29 is independently -CH 2 F. In some embodiments, R 29 is independently -CH 2 I. In some embodiments, R 29 is independently -CN. In some embodiments, R 29 is independently -OH. In some embodiments, R 29 is independently -NH 2 . In some embodiments, R 29 is independently -COOH. In some embodiments, R 29 is independently -CONH 2 . In some embodiments, R 29 is independently -NO 2 . In some embodiments, R 29 is independently -SH. In some embodiments, R 29 is independently -SO 3 H. In some embodiments, R 29 is independently -SO 4 H. In some embodiments, R 29 is independently -SO 2 NH 2 . In some embodiments, R 29 is independently -NHNH 2 . In some embodiments, R 29 is independently -ONH 2 . In some embodiments, R 29 is independently -NHC(O)NHNH 2 . In some embodiments, R 29 is independently -NHC(O)NH 2 . In some embodiments, R 29 is independently -NHSO 2 H. In some embodiments, R 29 is independently -NHC(O)H. In some embodiments, R 29 is independently -NHC(O)OH. In some embodiments, R 29 is independently -NHOH. In some embodiments, R 29 is independently -OCC1 3 . In some embodiments, R 29 is independently -OCF 3 . In some embodiments, R 29 is independently -OCBr 3 . In some embodiments, R 29 is independently -OC1 3 . In some embodiments, R 29 is independently -OCHC1 2 . In some embodiments, R 29 is independently -OCHBr 2 . In some embodiments, R 29 is independently -OCHI 2 . In some embodiments, R 29 is independently -OCHF 2 . In some embodiments, R 29 is independently -OCH 2 C1. In some embodiments, R 29 is independently -OCH 2 Br. In some embodiments, R 29 is independently -OCH 2 I. In some embodiments, R 29 is independently -OCH 2 F. In some embodiments, R 29 is independently -N 3 . In some embodiments, R 29 is independently –OCH 3 . In some embodiments, R 29 is independently –CH 3 . In some embodiments, R 29 is independently –CH 2 CH 3 . In some embodiments, R 29 is independently unsubstituted propyl. In some embodiments, R 29 is independently unsubstituted isopropyl. In some embodiments, R 29 is independently unsubstituted butyl. In some embodiments, R 29 is independently unsubstituted tert-butyl. In some embodiments, R 29 is independently –F. In some embodiments, R 29 is independently –C1. In some embodiments, R 29 is independently –Br. In some embodiments, R 29 is independently –I. [0315] In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form a substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form a substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form a substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form a substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form a substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an R 27 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an R 27 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an R 27 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an R 27 - substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an R 27 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an R 27 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an R 27 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, two (e.g., adjacent) R 3 substituents are independently joined to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0316] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3 position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3 position, R 3 is replaced with a divalent linker, referred to in this embodiment as L R3 . [0317] In some embodiments, L R3 is a bond, -S(O) 2 -, -S(O)-, -NR 1A -, =N-, -O-, -S-, -C(O)-, -C(O)NR 1A -, -NR 1A C(O)-, -NR 1A C(O)NH-, -NHC(O)NR 1A -, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. It will be understood that when –L R3 - is =N-, one of the two direct covalent connections to L R3 shown in “-L R3 -” is a double bond and L R3 may equivalently be shown as “=L R3 -” and the atom to which the double bond is directly attached must obey standard rules of chemical valency known in the chemical arts and be capable of forming such a double bond. [0318] In some embodiments, L R3 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R3 is independently a -S(O) 2 -. In some embodiments, L R3 is independently a -S(O)-. In some embodiments, L R3 is independently a -NH-. In some embodiments, L R3 is independently a -O-. In some embodiments, L R3 is independently a -S-. In some embodiments, L R3 is independently a -C(O)-. In some embodiments, L R3 is independently a -C(O)NH-. In some embodiments, L R3 is independently a -NHC(O)-. In some embodiments, L R3 is independently a -NHC(O)NH-. In some embodiments, L R3 is independently a -C(O)O-. In some embodiments, L R3 is independently -OC(O)-. In some embodiments, L R3 is independently – NR 3A -. In some embodiments, L R3 is independently -C(O)NR 3A -. In some embodiments, L R3 is independently –NR 3A C(O)-. In some embodiments, L R3 is independently –NR 3A C(O)NH-. In some embodiments, L R3 is independently -NHC(O)NR 3A -. In some embodiments, L R3 is independently a bond. [0319] In some embodiments, L R3 is substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R3 is substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R3 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R3 is substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R3 is substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R3 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R3 is substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R1 is substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R1 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R3 is substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R3 is substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R3 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R3 is substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R3 is substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R3 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R3 is substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R3 is substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R3 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0320] In some embodiments, L R3 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, R 27 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), R 27 - substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), R 27 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), R 27 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), R 27 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or R 27 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R3 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0321] In some embodiments, L R3 is R 27 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R3 is R 27 -substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R3 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L R3 is R 27 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R3 is R 27 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R3 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L R3 is R 27 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R3 is R 27 -substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R3 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L R3 is R 27 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R3 is R 27 -substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R3 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L R3 is R 27 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R3 is R 27 -substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R3 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L R3 is R 27 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R3 is R 27 -substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L R3 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0322] In some embodiments, R 3A is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0323] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3A position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3A position, R 3A is replaced with a divalent linker, referred to in this embodiment as L R3 . [0324] In some embodiments, R 3B is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0325] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3B position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3B position, R 3B is replaced with a divalent linker, referred to in this embodiment as L R3 . [0326] In some embodiments, R 3C is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0327] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3C position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3C position, R 3C is replaced with a divalent linker, referred to in this embodiment as L R3 . [0328] In some embodiments, R 3D is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0329] In some embodiments, the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3D position. In some embodiments, when the divalent linker bonded to both the monovalent cellular component binder and monovalent targeted autophagy protein binder is attached to the monovalent targeted autophagy protein binder at an R 3D position, R 3D is replaced with a divalent linker, referred to in this embodiment as L R3 . [0330] In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0331] In some embodiments, R 3A , R 3B , R 3C , and R 3D are independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , R 27 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 27 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 27 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 27 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 27 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form an R 27 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form an R 27 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl. In some embodiments, R 3A and R 3B substituents bonded to the same nitrogen atom are independently joined to form an R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0332] In some embodiments, R 3A is independently R 27 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3A is independently R 27 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3A is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3A is independently R 27 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3A is independently R 27 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3A is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3A is independently R 27 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3A is independently R 27 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3A is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3A is independently R 27 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3A is independently R 27 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3A is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3A is independently R 27 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3A is independently R 27 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3A is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3A is independently R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3A is independently R 27 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3A is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0333] In some embodiments, R 3A is independently -CC1 3 . In some embodiments, R 3A is independently -CBr 3 . In some embodiments, R 3A is independently -CF 3 . In some embodiments, R 3A is independently -C1 3 . In some embodiments, R 3A is independently -CHC1 2 . In some embodiments, R 3A is independently -CHBr 2 . In some embodiments, R 3A is independently -CHF 2 . In some embodiments, R 3A is independently -CHI 2 . In some embodiments, R 3A is independently -CH 2 C1. In some embodiments, R 3A is independently -CH 2 Br. In some embodiments, R 3A is independently -CH 2 F. In some embodiments, R 3A is independently -CH 2 I. In some embodiments, R 3A is independently -CN. In some embodiments, R 3A is independently -OH. In some embodiments, R 3A is independently -COOH. In some embodiments, R 3A is independently -CONH 2 . In some embodiments, R 3A is independently -OCC1 3 . In some embodiments, R 3A is independently -OCF 3 . In some embodiments, R 3A is independently -OCBr 3 . In some embodiments, R 3A is independently -OC1 3 . In some embodiments, R 3A is independently -OCHC1 2 . In some embodiments, R 3A is independently -OCHBr 2 . In some embodiments, R 3A is independently -OCHI 2 . In some embodiments, R 3A is independently -OCHF 2 . In some embodiments, R 3A is independently -OCH 2 C1. In some embodiments, R 3A is independently -OCH 2 Br. In some embodiments, R 3A is independently -OCH 2 I. In some embodiments, R 3A is independently -OCH 2 F. In some embodiments, R 3A is independently –OCH 3 . In some embodiments, R 3A is independently – CH 3 . In some embodiments, R 3A is independently –CH 2 CH 3 . In some embodiments, R 3A is independently unsubstituted propyl. In some embodiments, R 3A is independently unsubstituted isopropyl. In some embodiments, R 3A is independently unsubstituted butyl. In some embodiments, R 3A is independently unsubstituted tert-butyl. In some embodiments, R 3A is independently hydrogen. [0334] In some embodiments, R 3B is independently R 27 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3B is independently R 27 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3B is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3B is independently R 27 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3B is independently R 27 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3B is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3B is independently R 27 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3B is independently R 27 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3B is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3B is independently R 27 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3B is independently R 27 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3B is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3B is independently R 27 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3B is independently R 27 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3B is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3B is independently R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3B is independently R 27 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3B is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0335] In some embodiments, R 3B is independently -CC1 3 . In some embodiments, R 3B is independently -CBr 3 . In some embodiments, R 3B is independently -CF 3 . In some embodiments, R 3B is independently -C1 3 . In some embodiments, R 3B is independently -CHC1 2 . In some embodiments, R 3B is independently -CHBr 2 . In some embodiments, R 3B is independently -CHF 2 . In some embodiments, R 3B is independently -CHI 2 . In some embodiments, R 3B is independently -CH 2 C1. In some embodiments, R 3B is independently -CH 2 Br. In some embodiments, R 3B is independently -CH 2 F. In some embodiments, R 3B is independently -CH 2 I. In some embodiments, R 3B is independently -CN. In some embodiments, R 3B is independently -OH. In some embodiments, R 3B is independently -COOH. In some embodiments, R 3B is independently -CONH 2 . In some embodiments, R 3B is independently -OCC1 3 . In some embodiments, R 3B is independently -OCF 3 . In some embodiments, R 3B is independently -OCBr 3 . In some embodiments, R 3B is independently -OC1 3 . In some embodiments, R 3B is independently -OCHC1 2 . In some embodiments, R 3B is independently -OCHBr 2 . In some embodiments, R 3B is independently -OCHI 2 . In some embodiments, R 3B is independently -OCHF 2 . In some embodiments, R 3B is independently -OCH 2 C1. In some embodiments, R 3B is independently -OCH 2 Br. In some embodiments, R 3B is independently -OCH 2 I. In some embodiments, R 3B is independently -OCH 2 F. In some embodiments, R 3B is independently –OCH 3 . In some embodiments, R 3B is independently –CH 3 . In some embodiments, R 3B is independently –CH 2 CH 3 . In some embodiments, R 3B is independently unsubstituted propyl. In some embodiments, R 3B is independently unsubstituted isopropyl. In some embodiments, R 3B is independently unsubstituted butyl. In some embodiments, R 3B is independently unsubstituted tert-butyl. In some embodiments, R 3B is independently hydrogen. [0336] In some embodiments, R 3C is independently R 27 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3C is independently R 27 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3C is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3C is independently R 27 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3C is independently R 27 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3C is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3C is independently R 27 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3C is independently R 27 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3C is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3C is independently R 27 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3C is independently R 27 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3C is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3C is independently R 27 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3C is independently R 27 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3C is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3C is independently R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3C is independently R 27 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3C is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0337] In some embodiments, R 3C is independently -CC1 3 . In some embodiments, R 3C is independently -CBr 3 . In some embodiments, R 3C is independently -CF 3 . In some embodiments, R 3C is independently -C1 3 . In some embodiments, R 3C is independently -CHC1 2 . In some embodiments, R 3C is independently -CHBr 2 . In some embodiments, R 3C is independently -CHF 2 . In some embodiments, R 3C is independently -CHI 2 . In some embodiments, R 3C is independently -CH 2 C1. In some embodiments, R 3C is independently -CH 2 Br. In some embodiments, R 3C is independently -CH 2 F. In some embodiments, R 3C is independently -CH 2 I. In some embodiments, R 3C is independently -CN. In some embodiments, R 3C is independently -OH. In some embodiments, R 3C is independently -COOH. In some embodiments, R 3C is independently -CONH 2 . In some embodiments, R 3C is independently -OCC1 3 . In some embodiments, R 3C is independently -OCF 3 . In some embodiments, R 3C is independently -OCBr 3 . In some embodiments, R 3C is independently -OC1 3 . In some embodiments, R 3C is independently -OCHC1 2 . In some embodiments, R 3C is independently -OCHBr 2 . In some embodiments, R 3C is independently -OCHI 2 . In some embodiments, R 3C is independently -OCHF 2 . In some embodiments, R 3C is independently -OCH 2 C1. In some embodiments, R 3C is independently -OCH 2 Br. In some embodiments, R 3C is independently -OCH 2 I. In some embodiments, R 3C is independently -OCH 2 F. In some embodiments, R 3C is independently –OCH 3 . In some embodiments, R 3C is independently –CH 3 . In some embodiments, R 3C is independently –CH 2 CH 3 . In some embodiments, R 3C is independently unsubstituted propyl. In some embodiments, R 3C is independently unsubstituted isopropyl. In some embodiments, R 3C is independently unsubstituted butyl. In some embodiments, R 3C is independently unsubstituted tert-butyl. In some embodiments, R 3C is independently hydrogen. [0338] In some embodiments, R 3D is independently R 27 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3D is independently R 27 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3D is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 3D is independently R 27 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3D is independently R 27 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3D is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 3D is independently R 27 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3D is independently R 27 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3D is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 3D is independently R 27 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3D is independently R 27 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3D is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 3D is independently R 27 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3D is independently R 27 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3D is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 3D is independently R 27 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3D is independently R 27 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 3D is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0339] In some embodiments, R 3D is independently -CC1 3 . In some embodiments, R 3D is independently -CBr 3 . In some embodiments, R 3D is independently -CF 3 . In some embodiments, R 3D is independently -C1 3 . In some embodiments, R 3D is independently -CHC1 2 . In some embodiments, R 3D is independently -CHBr 2 . In some embodiments, R 3D is independently -CHF 2 . In some embodiments, R 3D is independently -CHI 2 . In some embodiments, R 3D is independently -CH 2 C1. In some embodiments, R 3D is independently -CH 2 Br. In some embodiments, R 3D is independently -CH 2 F. In some embodiments, R 3D is independently -CH 2 I. In some embodiments, R 3D is independently -CN. In some embodiments, R 3D is independently -OH. In some embodiments, R 3D is independently -COOH. In some embodiments, R 3D is independently -CONH 2 . In some embodiments, R 3D is independently -OCC1 3 . In some embodiments, R 3D is independently -OCF 3 . In some embodiments, R 3D is independently -OCBr 3 . In some embodiments, R 3D is independently -OC1 3 . In some embodiments, R 3D is independently -OCHC1 2 . In some embodiments, R 3D is independently -OCHBr 2 . In some embodiments, R 3D is independently -OCHI 2 . In some embodiments, R 3D is independently -OCHF 2 . In some embodiments, R 3D is independently -OCH 2 C1. In some embodiments, R 3D is independently -OCH 2 Br. In some embodiments, R 3D is independently -OCH 2 I. In some embodiments, R 3D is independently -OCH 2 F. In some embodiments, R 3D is independently –OCH 3 . In some embodiments, R 3D is independently – CH 3 . In some embodiments, R 3D is independently –CH 2 CH 3 . In some embodiments, R 3D is independently unsubstituted propyl. In some embodiments, R 3D is independently unsubstituted isopropyl. In some embodiments, R 3D is independently unsubstituted butyl. In some embodiments, R 3D is independently unsubstituted tert-butyl. In some embodiments, R 3D is independently hydrogen. [0340] In some embodiments, R 4 is [0341] In some embodiments, R 5 is independently hydrogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -COOH, -CONH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0342] In some embodiments, R 5 is independently substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5 is independently substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5 is independently substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5 is independently substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5 is independently substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5 is independently substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5 is independently an unsubstituted cycloalkyl (e.g., C 3 - C8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5 is independently substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5 is independently substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5 is independently substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5 is independently substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5 is independently substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5 is independently substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0343] In some embodiments, R 5 is independently hydrogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -COOH, -CONH 2 , R 33 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 33 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 33 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 33 - substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 33 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 33 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5 is independently hydrogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -COOH, -CONH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0344] In some embodiments, R 5 is independently R 33 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5 is independently R 33 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5 is independently R 33 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5 is independently R 33 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5 is independently R 33 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5 is independently R 33 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5 is independently an unsubstituted cycloalkyl (e.g., C3- C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5 is independently R 33 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5 is independently R 33 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5 is independently R 33 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5 is independently R 33 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5 is independently R 33 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5 is independently R 33 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0345] In some embodiments, R 5 is independently -CX 5 3. In some embodiments, R 5 is independently -CHX 5 2 . In some embodiments, R 5 is independently -CH 2 X 5 . In some embodiments, R 5 is independently -OCX 5 3. In some embodiments, R 5 is independently -OCH 2 X 5 . In some embodiments, R 5 is independently -OCHX 5 2 . In some embodiments, R 5 is independently -CN. In some embodiments, R 5 is independently -C(O)R 5C . In some embodiments, R 5 is independently -C(O)-OR 5C . In some embodiments, R 5 is independently -C(O)NR 5A R 5B . In some embodiments, R 5 is independently -OR 5D . In some embodiments, R 5 is independently hydrogen. X 5 is independently halogen. [0346] In some embodiments, R 5 is independently -CC1 3 . In some embodiments, R 5 is independently -CBr 3 . In some embodiments, R 5 is independently -CF 3 . In some embodiments, R 5 is independently -C1 3 . In some embodiments, R 5 is independently -CHC1 2 . In some embodiments, R 5 is independently -CHBr 2 . In some embodiments, R 5 is independently -CHF 2 . In some embodiments, R 5 is independently -CHI 2 . In some embodiments, R 5 is independently -CH 2 C1. In some embodiments, R 5 is independently -CH 2 Br. In some embodiments, R 5 is independently -CH 2 F. In some embodiments, R 5 is independently -CH 2 I. In some embodiments, R 5 is independently -CN. In some embodiments, R 5 is independently -OH. In some embodiments, R 5 is independently -COOH. In some embodiments, R 5 is independently -CONH 2 . In some embodiments, R 5 is independently -OCC1 3 . In some embodiments, R 5 is independently -OCF 3 . In some embodiments, R 5 is independently -OCBr 3 . In some embodiments, R 5 is independently -OC1 3 . In some embodiments, R 5 is independently -OCHC1 2 . In some embodiments, R 5 is independently -OCHBr 2 . In some embodiments, R 5 is independently -OCHI 2 . In some embodiments, R 5 is independently -OCHF 2 . In some embodiments, R 5 is independently -OCH 2 C1. In some embodiments, R 5 is independently -OCH 2 Br. In some embodiments, R 5 is independently -OCH 2 I. In some embodiments, R 5 is independently -OCH 2 F. In some embodiments, R 5 is independently –OCH 3 . In some embodiments, R 5 is independently –CH 3 . In some embodiments, R 5 is independently –CH 2 CH 3 . In some embodiments, R 5 is independently unsubstituted propyl. In some embodiments, R 5 is independently unsubstituted isopropyl. In some embodiments, R 5 is independently unsubstituted butyl. In some embodiments, R 5 is independently unsubstituted tert-butyl. In some embodiments, X 5 is independently –F. In some embodiments, X 5 is independently –C1. In some embodiments, X 5 is independently –Br. In some embodiments, X 5 is independently –I. [0347] In some embodiments, R 33 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 34 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 34 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 34 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 34 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 34 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 34 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 33 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0348] In some embodiments, R 33 is independently oxo. In some embodiments, R 33 is independently halogen. In some embodiments, R 33 is independently -CC1 3 . In some embodiments, R 33 is independently -CBr 3 . In some embodiments, R 33 is independently -CF 3 . In some embodiments, R 33 is independently -C1 3 . In some embodiments, R 33 is independently -CHC1 2 . In some embodiments, R 33 is independently -CHBr 2 . In some embodiments, R 33 is independently -CHF 2 . In some embodiments, R 33 is independently -CHI 2 . In some embodiments, R 33 is independently -CH 2 C1. In some embodiments, R 33 is independently -CH 2 Br. In some embodiments, R 33 is independently -CH 2 F. In some embodiments, R 33 is independently -CH 2 I. In some embodiments, R 33 is independently -CN. In some embodiments, R 33 is independently -OH. In some embodiments, R 33 is independently -NH 2 . In some embodiments, R 33 is independently -COOH. In some embodiments, R 33 is independently -CONH 2 . In some embodiments, R 33 is independently -NO 2 . In some embodiments, R 33 is independently -SH. In some embodiments, R 33 is independently -SO 3 H. In some embodiments, R 33 is independently -SO 4 H. In some embodiments, R 33 is independently -SO 2 NH 2 . In some embodiments, R 33 is independently -NHNH 2 . In some embodiments, R 33 is independently -ONH 2 . In some embodiments, R 33 is independently -NHC(O)NHNH 2 . In some embodiments, R 33 is independently -NHC(O)NH 2 . In some embodiments, R 33 is independently -NHSO 2 H. In some embodiments, R 33 is independently -NHC(O)H. In some embodiments, R 33 is independently -NHC(O)OH. In some embodiments, R 33 is independently -NHOH. In some embodiments, R 33 is independently -OCC1 3 . In some embodiments, R 33 is independently -OCF 3 . In some embodiments, R 33 is independently -OCBr 3 . In some embodiments, R 33 is independently -OC1 3 . In some embodiments, R 33 is independently -OCHC1 2 . In some embodiments, R 33 is independently -OCHBr 2 . In some embodiments, R 33 is independently -OCHI 2 . In some embodiments, R 33 is independently -OCHF 2 . In some embodiments, R 33 is independently -OCH 2 C1. In some embodiments, R 33 is independently -OCH 2 Br. In some embodiments, R 33 is independently -OCH 2 I. In some embodiments, R 33 is independently -OCH 2 F. In some embodiments, R 33 is independently -N 3 . In some embodiments, R 33 is independently –OCH 3 . In some embodiments, R 33 is independently –CH 3 . In some embodiments, R 33 is independently –CH 2 CH 3 . In some embodiments, R 33 is independently unsubstituted propyl. In some embodiments, R 33 is independently unsubstituted isopropyl. In some embodiments, R 33 is independently unsubstituted butyl. In some embodiments, R 33 is independently unsubstituted tert-butyl. In some embodiments, R 33 is independently –F. In some embodiments, R 33 is independently –C1. In some embodiments, R 33 is independently –Br. In some embodiments, R 33 is independently –I. [0349] In some embodiments, R 33 is independently R 34 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 33 is independently R 34 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 33 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 33 is independently R 34 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 33 is independently R 34 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 33 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 33 is independently R 34 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 33 is independently R 34 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 33 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 33 is independently R 34 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 33 is independently R 34 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 33 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 33 is independently R 34 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 33 is independently R 34 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 33 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 33 is independently R 34 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 33 is independently R 34 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 33 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0350] In some embodiments, R 34 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 35 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 35 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 35 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 35 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 35 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 35 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 34 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0351] In some embodiments, R 34 is independently R 35 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 34 is independently R 35 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 34 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 34 is independently R 35 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 34 is independently R 35 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 34 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 34 is independently R 35 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 34 is independently R 35 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 34 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 34 is independently R 35 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 34 is independently R 35 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 34 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 34 is independently R 35 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 34 is independently R 35 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 34 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 34 is independently R 35 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 34 is independently R 35 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 34 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0352] In some embodiments, R 34 is independently oxo. In some embodiments, R 34 is independently halogen. In some embodiments, R 34 is independently -CC1 3 . In some embodiments, R 34 is independently -CBr 3 . In some embodiments, R 34 is independently -CF 3 . In some embodiments, R 34 is independently -C1 3 . In some embodiments, R 34 is independently -CHC1 2 . In some embodiments, R 34 is independently -CHBr 2 . In some embodiments, R 34 is independently -CHF 2 . In some embodiments, R 34 is independently -CHI 2 . In some embodiments, R 34 is independently -CH 2 C1. In some embodiments, R 34 is independently -CH 2 Br. In some embodiments, R 34 is independently -CH 2 F. In some embodiments, R 34 is independently -CH 2 I. In some embodiments, R 34 is independently -CN. In some embodiments, R 34 is independently -OH. In some embodiments, R 34 is independently -NH 2 . In some embodiments, R 34 is independently -COOH. In some embodiments, R 34 is independently -CONH 2 . In some embodiments, R 34 is independently -NO 2 . In some embodiments, R 34 is independently -SH. In some embodiments, R 34 is independently -SO 3 H. In some embodiments, R 34 is independently -SO 4 H. In some embodiments, R 34 is independently -SO 2 NH 2 . In some embodiments, R 34 is independently -NHNH 2 . In some embodiments, R 34 is independently -ONH 2 . In some embodiments, R 34 is independently -NHC(O)NHNH 2 . In some embodiments, R 34 is independently -NHC(O)NH 2 . In some embodiments, R 34 is independently -NHSO 2 H. In some embodiments, R 34 is independently -NHC(O)H. In some embodiments, R 34 is independently -NHC(O)OH. In some embodiments, R 34 is independently -NHOH. In some embodiments, R 34 is independently -OCC1 3 . In some embodiments, R 34 is independently -OCF 3 . In some embodiments, R 34 is independently -OCBr 3 . In some embodiments, R 34 is independently -OC1 3 . In some embodiments, R 34 is independently -OCHC1 2 . In some embodiments, R 34 is independently -OCHBr 2 . In some embodiments, R 34 is independently -OCHI 2 . In some embodiments, R 34 is independently -OCHF 2 . In some embodiments, R 34 is independently -OCH 2 C1. In some embodiments, R 34 is independently -OCH 2 Br. In some embodiments, R 34 is independently -OCH 2 I. In some embodiments, R 34 is independently -OCH 2 F. In some embodiments, R 34 is independently -N 3 . In some embodiments, R 34 is independently –OCH 3 . In some embodiments, R 34 is independently –CH 3 . In some embodiments, R 34 is independently –CH 2 CH 3 . In some embodiments, R 34 is independently unsubstituted propyl. In some embodiments, R 34 is independently unsubstituted isopropyl. In some embodiments, R 34 is independently unsubstituted butyl. In some embodiments, R 34 is independently unsubstituted tert-butyl. In some embodiments, R 34 is independently –F. In some embodiments, R 34 is independently –C1. In some embodiments, R 34 is independently –Br. In some embodiments, R 34 is independently –I. [0353] In some embodiments, R 35 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0354] In some embodiments, R 35 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 35 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 35 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 35 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 35 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 35 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0355] In some embodiments, R 35 is independently oxo. In some embodiments, R 35 is independently halogen. In some embodiments, R 35 is independently -CC1 3 . In some embodiments, R 35 is independently -CBr 3 . In some embodiments, R 35 is independently -CF 3 . In some embodiments, R 35 is independently -C1 3 . In some embodiments, R 35 is independently -CHC1 2 . In some embodiments, R 35 is independently -CHBr 2 . In some embodiments, R 35 is independently -CHF 2 . In some embodiments, R 35 is independently -CHI 2 . In some embodiments, R 35 is independently -CH 2 C1. In some embodiments, R 35 is independently -CH 2 Br. In some embodiments, R 35 is independently -CH 2 F. In some embodiments, R 35 is independently -CH 2 I. In some embodiments, R 35 is independently -CN. In some embodiments, R 35 is independently -OH. In some embodiments, R 35 is independently -NH 2 . In some embodiments, R 35 is independently -COOH. In some embodiments, R 35 is independently -CONH 2 . In some embodiments, R 35 is independently -NO 2 . In some embodiments, R 35 is independently -SH. In some embodiments, R 35 is independently -SO 3 H. In some embodiments, R 35 is independently -SO 4 H. In some embodiments, R 35 is independently -SO 2 NH 2 . In some embodiments, R 35 is independently -NHNH 2 . In some embodiments, R 35 is independently -ONH 2 . In some embodiments, R 35 is independently -NHC(O)NHNH 2 . In some embodiments, R 35 is independently -NHC(O)NH 2 . In some embodiments, R 35 is independently -NHSO 2 H. In some embodiments, R 35 is independently -NHC(O)H. In some embodiments, R 35 is independently -NHC(O)OH. In some embodiments, R 35 is independently -NHOH. In some embodiments, R 35 is independently -OCC1 3 . In some embodiments, R 35 is independently -OCF 3 . In some embodiments, R 35 is independently -OCBr 3 . In some embodiments, R 35 is independently -OC1 3 . In some embodiments, R 35 is independently -OCHC1 2 . In some embodiments, R 35 is independently -OCHBr 2 . In some embodiments, R 35 is independently -OCHI 2 . In some embodiments, R 35 is independently -OCHF 2 . In some embodiments, R 35 is independently -OCH 2 C1. In some embodiments, R 35 is independently -OCH 2 Br. In some embodiments, R 35 is independently -OCH 2 I. In some embodiments, R 35 is independently -OCH 2 F. In some embodiments, R 35 is independently -N 3 . In some embodiments, R 35 is independently –OCH 3 . In some embodiments, R 35 is independently –CH 3 . In some embodiments, R 35 is independently –CH 2 CH 3 . In some embodiments, R 35 is independently unsubstituted propyl. In some embodiments, R 35 is independently unsubstituted isopropyl. In some embodiments, R 35 is independently unsubstituted butyl. In some embodiments, R 35 is independently unsubstituted tert-butyl. In some embodiments, R 35 is independently –F. In some embodiments, R 35 is independently –C1. In some embodiments, R 35 is independently –Br. In some embodiments, R 35 is independently –I. [0356] In some embodiments, R 5A is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0357] In some embodiments, R 5B is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0358] In some embodiments, R 5C is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0359] In some embodiments, R 5D is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0360] In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0361] In some embodiments, R 5A , R 5B , R 5C , and R 5D are independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , R 33 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 33 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 33 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 33 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 33 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 33 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form an R 33 - substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or R 33 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form an R 33 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl. In some embodiments, R 5A and R 5B substituents bonded to the same nitrogen atom are independently joined to form an R 33 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0362] In some embodiments, R 5A is independently R 33 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5A is independently R 33 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5A is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5A is independently R 33 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5A is independently R 33 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5A is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5A is independently R 33 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5A is independently R 33 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5A is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5A is independently R 33 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5A is independently R 33 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5A is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5A is independently R 33 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5A is independently R 33 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5A is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5A is independently R 33 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5A is independently R 33 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5A is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0363] In some embodiments, R 5A is independently -CC1 3 . In some embodiments, R 5A is independently -CBr 3 . In some embodiments, R 5A is independently -CF 3 . In some embodiments, R 5A is independently -C1 3 . In some embodiments, R 5A is independently -CHC1 2 . In some embodiments, R 5A is independently -CHBr 2 . In some embodiments, R 5A is independently -CHF 2 . In some embodiments, R 5A is independently -CHI 2 . In some embodiments, R 5A is independently -CH 2 C1. In some embodiments, R 5A is independently -CH 2 Br. In some embodiments, R 5A is independently -CH 2 F. In some embodiments, R 5A is independently -CH 2 I. In some embodiments, R 5A is independently -CN. In some embodiments, R 5A is independently -OH. In some embodiments, R 5A is independently -COOH. In some embodiments, R 5A is independently -CONH 2 . In some embodiments, R 5A is independently -OCC1 3 . In some embodiments, R 5A is independently -OCF 3 . In some embodiments, R 5A is independently -OCBr 3 . In some embodiments, R 5A is independently -OC1 3 . In some embodiments, R 5A is independently -OCHC1 2 . In some embodiments, R 5A is independently -OCHBr 2 . In some embodiments, R 5A is independently -OCHI 2 . In some embodiments, R 5A is independently -OCHF 2 . In some embodiments, R 5A is independently -OCH 2 C1. In some embodiments, R 5A is independently -OCH 2 Br. In some embodiments, R 5A is independently -OCH 2 I. In some embodiments, R 5A is independently -OCH 2 F. In some embodiments, R 5A is independently –OCH 3 . In some embodiments, R 5A is independently –CH 3 . In some embodiments, R 5A is independently –CH 2 CH 3 . In some embodiments, R 5A is independently unsubstituted propyl. In some embodiments, R 5A is independently unsubstituted isopropyl. In some embodiments, R 5A is independently unsubstituted butyl. In some embodiments, R 5A is independently unsubstituted tert-butyl. In some embodiments, R 5A is independently hydrogen. [0364] In some embodiments, R 5B is independently R 33 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5B is independently R 33 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5B is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5B is independently R 33 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5B is independently R 33 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5B is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5B is independently R 33 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5B is independently R 33 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5B is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5B is independently R 33 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5B is independently R 33 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5B is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5B is independently R 33 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5B is independently R 33 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5B is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5B is independently R 33 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5B is independently R 33 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5B is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0365] In some embodiments, R 5B is independently -CC1 3 . In some embodiments, R 5B is independently -CBr 3 . In some embodiments, R 5B is independently -CF 3 . In some embodiments, R 5B is independently -C1 3 . In some embodiments, R 5B is independently -CHC1 2 . In some embodiments, R 5B is independently -CHBr 2 . In some embodiments, R 5B is independently -CHF 2 . In some embodiments, R 5B is independently -CHI 2 . In some embodiments, R 5B is independently -CH 2 C1. In some embodiments, R 5B is independently -CH 2 Br. In some embodiments, R 5B is independently -CH 2 F. In some embodiments, R 5B is independently -CH 2 I. In some embodiments, R 5B is independently -CN. In some embodiments, R 5B is independently -OH. In some embodiments, R 5B is independently -COOH. In some embodiments, R 5B is independently -CONH 2 . In some embodiments, R 5B is independently -OCC1 3 . In some embodiments, R 5B is independently -OCF 3 . In some embodiments, R 5B is independently -OCBr 3 . In some embodiments, R 5B is independently -OC1 3 . In some embodiments, R 5B is independently -OCHC1 2 . In some embodiments, R 5B is independently -OCHBr 2 . In some embodiments, R 5B is independently -OCHI 2 . In some embodiments, R 5B is independently -OCHF 2 . In some embodiments, R 5B is independently -OCH 2 C1. In some embodiments, R 5B is independently -OCH 2 Br. In some embodiments, R 5B is independently -OCH 2 I. In some embodiments, R 5B is independently -OCH 2 F. In some embodiments, R 5B is independently –OCH 3 . In some embodiments, R 5B is independently –CH 3 . In some embodiments, R 5B is independently – CH 2 CH 3 . In some embodiments, R 5B is independently unsubstituted propyl. In some embodiments, R 5B is independently unsubstituted isopropyl. In some embodiments, R 5B is independently unsubstituted butyl. In some embodiments, R 5B is independently unsubstituted tert-butyl. In some embodiments, R 5B is independently hydrogen. [0366] In some embodiments, R 5C is independently R 33 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5C is independently R 33 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5C is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5C is independently R 33 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5C is independently R 33 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5C is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5C is independently R 33 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5C is independently R 33 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5C is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5C is independently R 33 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5C is independently R 33 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5C is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5C is independently R 33 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5C is independently R 33 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5C is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5C is independently R 33 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5C is independently R 33 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5C is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0367] In some embodiments, R 5C is independently -CC1 3 . In some embodiments, R 5C is independently -CBr 3 . In some embodiments, R 5C is independently -CF 3 . In some embodiments, R 5C is independently -C1 3 . In some embodiments, R 5C is independently -CHC1 2 . In some embodiments, R 5C is independently -CHBr 2 . In some embodiments, R 5C is independently -CHF 2 . In some embodiments, R 5C is independently -CHI 2 . In some embodiments, R 5C is independently -CH 2 C1. In some embodiments, R 5C is independently -CH 2 Br. In some embodiments, R 5C is independently -CH 2 F. In some embodiments, R 5C is independently -CH 2 I. In some embodiments, R 5C is independently -CN. In some embodiments, R 5C is independently -OH. In some embodiments, R 5C is independently -COOH. In some embodiments, R 5C is independently -CONH 2 . In some embodiments, R 5C is independently -OCC1 3 . In some embodiments, R 5C is independently -OCF 3 . In some embodiments, R 5C is independently -OCBr 3 . In some embodiments, R 5C is independently -OC1 3 . In some embodiments, R 5C is independently -OCHC1 2 . In some embodiments, R 5C is independently -OCHBr 2 . In some embodiments, R 5C is independently -OCHI 2 . In some embodiments, R 5C is independently -OCHF 2 . In some embodiments, R 5C is independently -OCH 2 C1. In some embodiments, R 5C is independently -OCH 2 Br. In some embodiments, R 5C is independently -OCH 2 I. In some embodiments, R 5C is independently -OCH 2 F. In some embodiments, R 5C is independently –OCH 3 . In some embodiments, R 5C is independently –CH 3 . In some embodiments, R 5C is independently –CH 2 CH 3 . In some embodiments, R 5C is independently unsubstituted propyl. In some embodiments, R 5C is independently unsubstituted isopropyl. In some embodiments, R 5C is independently unsubstituted butyl. In some embodiments, R 5C is independently unsubstituted tert-butyl. In some embodiments, R 5C is independently hydrogen. [0368] In some embodiments, R 5D is independently R 33 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5D is independently R 33 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5D is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 5D is independently R 33 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5D is independently R 33 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5D is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 5D is independently R 33 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5D is independently R 33 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5D is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 5D is independently R 33 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5D is independently R 33 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5D is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 5D is independently R 33 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5D is independently R 33 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5D is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 5D is independently R 33 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5D is independently R 33 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 5D is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0369] In some embodiments, R 5D is independently -CC1 3 . In some embodiments, R 5D is independently -CBr 3 . In some embodiments, R 5D is independently -CF 3 . In some embodiments, R 5D is independently -C1 3 . In some embodiments, R 5D is independently -CHC1 2 . In some embodiments, R 5D is independently -CHBr 2 . In some embodiments, R 5D is independently -CHF 2 . In some embodiments, R 5D is independently -CHI 2 . In some embodiments, R 5D is independently -CH 2 C1. In some embodiments, R 5D is independently -CH 2 Br. In some embodiments, R 5D is independently -CH 2 F. In some embodiments, R 5D is independently -CH 2 I. In some embodiments, R 5D is independently -CN. In some embodiments, R 5D is independently -OH. In some embodiments, R 5D is independently -COOH. In some embodiments, R 5D is independently -CONH 2 . In some embodiments, R 5D is independently -OCC1 3 . In some embodiments, R 5D is independently -OCF 3 . In some embodiments, R 5D is independently -OCBr 3 . In some embodiments, R 5D is independently -OC1 3 . In some embodiments, R 5D is independently -OCHC1 2 . In some embodiments, R 5D is independently -OCHBr 2 . In some embodiments, R 5D is independently -OCHI 2 . In some embodiments, R 5D is independently -OCHF 2 . In some embodiments, R 5D is independently -OCH 2 C1. In some embodiments, R 5D is independently -OCH 2 Br. In some embodiments, R 5D is independently -OCH 2 I. In some embodiments, R 5D is independently -OCH 2 F. In some embodiments, R 5D is independently –OCH 3 . In some embodiments, R 5D is independently –CH 3 . In some embodiments, R 5D is independently –CH 2 CH 3 . In some embodiments, R 5D is independently unsubstituted propyl. In some embodiments, R 5D is independently unsubstituted isopropyl. In some embodiments, R 5D is independently unsubstituted butyl. In some embodiments, R 5D is independently unsubstituted tert-butyl. In some embodiments, R 5D is independently hydrogen. [0370] In some embodiments, R 6 is independently hydrogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -COOH, -CONH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0371] In some embodiments, R 6 is independently substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6 is independently substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6 is independently substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6 is independently substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6 is independently substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6 is independently substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6 is independently an unsubstituted cycloalkyl (e.g., C3- C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6 is independently substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6 is independently substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6 is independently substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6 is independently substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6 is independently substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6 is independently substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0372] In some embodiments, R 6 is independently hydrogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -COOH, -CONH 2 , R 36 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 36 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 36 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 36 - substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 36 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 36 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6 is independently hydrogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -COOH, -CONH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0373] In some embodiments, R 6 is independently R 36 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6 is independently R 36 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6 is independently R 36 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6 is independently R 36 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6 is independently R 36 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6 is independently R 36 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6 is independently an unsubstituted cycloalkyl (e.g., C 3 - C8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6 is independently R 36 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6 is independently R 36 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6 is independently R 36 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6 is independently R 36 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6 is independently R 36 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6 is independently R 36 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0374] In some embodiments, R 6 is independently - . In some embodiments, R 6 is independently -CHX 6 2. In some embodiments, R 6 is independently -CH 2 X 6 . In some embodiments, R 6 is independently -OCX 6 3 . In some embodiments, R 6 is independently - OCH 2 X 6 . In some embodiments, R 6 is independently -OCHX 6 2. In some embodiments, R 6 is independently -CN. In some embodiments, R 6 is independently -C(O)R 6C . In some embodiments, R 6 is independently -C(O)-OR 6C . In some embodiments, R 6 is independently -C(O)NR 6A R 6B . In some embodiments, R 6 is independently -OR 6D . In some embodiments, R 6 is independently hydrogen. X 6 is independently halogen. [0375] In some embodiments, R 6 is independently -CC1 3 . In some embodiments, R 6 is independently -CBr 3 . In some embodiments, R 6 is independently -CF 3 . In some embodiments, R 6 is independently -C1 3 . In some embodiments, R 6 is independently -CHC1 2 . In some embodiments, R 6 is independently -CHBr 2 . In some embodiments, R 6 is independently -CHF 2 . In some embodiments, R 6 is independently -CHI 2 . In some embodiments, R 6 is independently -CH 2 C1. In some embodiments, R 6 is independently -CH 2 Br. In some embodiments, R 6 is independently -CH 2 F. In some embodiments, R 6 is independently -CH 2 I. In some embodiments, R 6 is independently -CN. In some embodiments, R 6 is independently -OH. In some embodiments, R 6 is independently -COOH. In some embodiments, R 6 is independently -CONH 2 . In some embodiments, R 6 is independently -OCC1 3 . In some embodiments, R 6 is independently -OCF 3 . In some embodiments, R 6 is independently -OCBr 3 . In some embodiments, R 6 is independently -OC1 3 . In some embodiments, R 6 is independently -OCHC1 2 . In some embodiments, R 6 is independently -OCHBr 2 . In some embodiments, R 6 is independently -OCHI 2 . In some embodiments, R 6 is independently -OCHF 2 . In some embodiments, R 6 is independently -OCH 2 C1. In some embodiments, R 6 is independently -OCH 2 Br. In some embodiments, R 6 is independently -OCH 2 I. In some embodiments, R 6 is independently -OCH 2 F. In some embodiments, R 6 is independently –OCH 3 . In some embodiments, R 6 is independently –CH 3 . In some embodiments, R 6 is independently –CH 2 CH 3 . In some embodiments, R 6 is independently unsubstituted propyl. In some embodiments, R 6 is independently unsubstituted isopropyl. In some embodiments, R 6 is independently unsubstituted butyl. In some embodiments, R 6 is independently unsubstituted tert-butyl. In some embodiments, X 6 is independently –F. In some embodiments, X 6 is independently –C1. In some embodiments, X 6 is independently –Br. In some embodiments, X 6 is independently –I. [0376] In some embodiments, R 36 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 37 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 37 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 37 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 37 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 37 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 37 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 36 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0377] In some embodiments, R 36 is independently oxo. In some embodiments, R 36 is independently halogen. In some embodiments, R 36 is independently -CC1 3 . In some embodiments, R 36 is independently -CBr 3 . In some embodiments, R 36 is independently -CF 3 . In some embodiments, R 36 is independently -C1 3 . In some embodiments, R 36 is independently -CHC1 2 . In some embodiments, R 36 is independently -CHBr 2 . In some embodiments, R 36 is independently -CHF 2 . In some embodiments, R 36 is independently -CHI 2 . In some embodiments, R 36 is independently -CH 2 C1. In some embodiments, R 36 is independently -CH 2 Br. In some embodiments, R 36 is independently -CH 2 F. In some embodiments, R 36 is independently -CH 2 I. In some embodiments, R 36 is independently -CN. In some embodiments, R 36 is independently -OH. In some embodiments, R 36 is independently -NH 2 . In some embodiments, R 36 is independently -COOH. In some embodiments, R 36 is independently -CONH 2 . In some embodiments, R 36 is independently -NO 2 . In some embodiments, R 36 is independently -SH. In some embodiments, R 36 is independently -SO 3 H. In some embodiments, R 36 is independently -SO 4 H. In some embodiments, R 36 is independently -SO 2 NH 2 . In some embodiments, R 36 is independently -NHNH 2 . In some embodiments, R 36 is independently -ONH 2 . In some embodiments, R 36 is independently -NHC(O)NHNH 2 . In some embodiments, R 36 is independently -NHC(O)NH 2 . In some embodiments, R 36 is independently -NHSO 2 H. In some embodiments, R 36 is independently -NHC(O)H. In some embodiments, R 36 is independently -NHC(O)OH. In some embodiments, R 36 is independently -NHOH. In some embodiments, R 36 is independently -OCC1 3 . In some embodiments, R 36 is independently -OCF 3 . In some embodiments, R 36 is independently -OCBr 3 . In some embodiments, R 36 is independently -OC1 3 . In some embodiments, R 36 is independently -OCHC1 2 . In some embodiments, R 36 is independently -OCHBr 2 . In some embodiments, R 36 is independently -OCHI 2 . In some embodiments, R 36 is independently -OCHF 2 . In some embodiments, R 36 is independently -OCH 2 C1. In some embodiments, R 36 is independently -OCH 2 Br. In some embodiments, R 36 is independently -OCH 2 I. In some embodiments, R 36 is independently -OCH 2 F. In some embodiments, R 36 is independently -N 3 . In some embodiments, R 36 is independently –OCH 3 . In some embodiments, R 36 is independently –CH 3 . In some embodiments, R 36 is independently –CH 2 CH 3 . In some embodiments, R 36 is independently unsubstituted propyl. In some embodiments, R 36 is independently unsubstituted isopropyl. In some embodiments, R 36 is independently unsubstituted butyl. In some embodiments, R 36 is independently unsubstituted tert-butyl. In some embodiments, R 36 is independently –F. In some embodiments, R 36 is independently –C1. In some embodiments, R 36 is independently –Br. In some embodiments, R 36 is independently –I. [0378] In some embodiments, R 36 is independently R 37 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 36 is independently R 37 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 36 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 36 is independently R 37 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 36 is independently R 37 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 36 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 36 is independently R 37 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 36 is independently R 37 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 36 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 36 is independently R 37 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 36 is independently R 37 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 36 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 36 is independently R 37 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 36 is independently R 37 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 36 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 36 is independently R 37 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 36 is independently R 37 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 36 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0379] In some embodiments, R 37 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 38 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 38 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 38 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 38 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 38 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 38 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 37 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0380] In some embodiments, R 37 is independently R 38 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 37 is independently R 38 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 37 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 37 is independently R 38 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 37 is independently R 38 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 37 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 37 is independently R 38 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 37 is independently R 38 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 37 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 37 is independently R 38 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 37 is independently R 38 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 37 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 37 is independently R 38 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 37 is independently R 38 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 37 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 37 is independently R 38 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 37 is independently R 38 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 37 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0381] In some embodiments, R 37 is independently oxo. In some embodiments, R 37 is independently halogen. In some embodiments, R 37 is independently -CC1 3 . In some embodiments, R 37 is independently -CBr 3 . In some embodiments, R 37 is independently -CF 3 . In some embodiments, R 37 is independently -C1 3 . In some embodiments, R 37 is independently -CHC1 2 . In some embodiments, R 37 is independently -CHBr 2 . In some embodiments, R 37 is independently -CHF 2 . In some embodiments, R 37 is independently -CHI 2 . In some embodiments, R 37 is independently -CH 2 C1. In some embodiments, R 37 is independently -CH 2 Br. In some embodiments, R 37 is independently -CH 2 F. In some embodiments, R 37 is independently -CH 2 I. In some embodiments, R 37 is independently -CN. In some embodiments, R 37 is independently -OH. In some embodiments, R 37 is independently -NH 2 . In some embodiments, R 37 is independently -COOH. In some embodiments, R 37 is independently -CONH 2 . In some embodiments, R 37 is independently -NO 2 . In some embodiments, R 37 is independently -SH. In some embodiments, R 37 is independently -SO 3 H. In some embodiments, R 37 is independently -SO 4 H. In some embodiments, R 37 is independently -SO 2 NH 2 . In some embodiments, R 37 is independently -NHNH 2 . In some embodiments, R 37 is independently -ONH 2 . In some embodiments, R 37 is independently -NHC(O)NHNH 2 . In some embodiments, R 37 is independently -NHC(O)NH 2 . In some embodiments, R 37 is independently -NHSO 2 H. In some embodiments, R 37 is independently -NHC(O)H. In some embodiments, R 37 is independently -NHC(O)OH. In some embodiments, R 37 is independently -NHOH. In some embodiments, R 37 is independently -OCC1 3 . In some embodiments, R 37 is independently -OCF 3 . In some embodiments, R 37 is independently -OCBr 3 . In some embodiments, R 37 is independently -OC1 3 . In some embodiments, R 37 is independently -OCHC1 2 . In some embodiments, R 37 is independently -OCHBr 2 . In some embodiments, R 37 is independently -OCHI 2 . In some embodiments, R 37 is independently -OCHF 2 . In some embodiments, R 37 is independently -OCH 2 C1. In some embodiments, R 37 is independently -OCH 2 Br. In some embodiments, R 37 is independently -OCH 2 I. In some embodiments, R 37 is independently -OCH 2 F. In some embodiments, R 37 is independently -N 3 . In some embodiments, R 37 is independently –OCH 3 . In some embodiments, R 37 is independently – CH 3 . In some embodiments, R 37 is independently –CH 2 CH 3 . In some embodiments, R 37 is independently unsubstituted propyl. In some embodiments, R 37 is independently unsubstituted isopropyl. In some embodiments, R 37 is independently unsubstituted butyl. In some embodiments, R 37 is independently unsubstituted tert-butyl. In some embodiments, R 37 is independently –F. In some embodiments, R 37 is independently –C1. In some embodiments, R 37 is independently –Br. In some embodiments, R 37 is independently –I. [0382] In some embodiments, R 38 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0383] In some embodiments, R 38 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 38 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 38 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 38 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 38 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 38 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0384] In some embodiments, R 38 is independently oxo. In some embodiments, R 38 is independently halogen. In some embodiments, R 38 is independently -CC1 3 . In some embodiments, R 38 is independently -CBr 3 . In some embodiments, R 38 is independently -CF 3 . In some embodiments, R 38 is independently -C1 3 . In some embodiments, R 38 is independently -CHC1 2 . In some embodiments, R 38 is independently -CHBr 2 . In some embodiments, R 38 is independently -CHF 2 . In some embodiments, R 38 is independently -CHI 2 . In some embodiments, R 38 is independently -CH 2 C1. In some embodiments, R 38 is independently -CH 2 Br. In some embodiments, R 38 is independently -CH 2 F. In some embodiments, R 38 is independently -CH 2 I. In some embodiments, R 38 is independently -CN. In some embodiments, R 38 is independently -OH. In some embodiments, R 38 is independently -NH 2 . In some embodiments, R 38 is independently -COOH. In some embodiments, R 38 is independently -CONH 2 . In some embodiments, R 38 is independently -NO 2 . In some embodiments, R 38 is independently -SH. In some embodiments, R 38 is independently -SO 3 H. In some embodiments, R 38 is independently -SO 4 H. In some embodiments, R 38 is independently -SO 2 NH 2 . In some embodiments, R 38 is independently -NHNH 2 . In some embodiments, R 38 is independently -ONH 2 . In some embodiments, R 38 is independently -NHC(O)NHNH 2 . In some embodiments, R 38 is independently -NHC(O)NH 2 . In some embodiments, R 38 is independently -NHSO 2 H. In some embodiments, R 38 is independently -NHC(O)H. In some embodiments, R 38 is independently -NHC(O)OH. In some embodiments, R 38 is independently -NHOH. In some embodiments, R 38 is independently -OCC1 3 . In some embodiments, R 38 is independently -OCF 3 . In some embodiments, R 38 is independently -OCBr 3 . In some embodiments, R 38 is independently -OC1 3 . In some embodiments, R 38 is independently -OCHC1 2 . In some embodiments, R 38 is independently -OCHBr 2 . In some embodiments, R 38 is independently -OCHI 2 . In some embodiments, R 38 is independently -OCHF 2 . In some embodiments, R 38 is independently -OCH 2 C1. In some embodiments, R 38 is independently -OCH 2 Br. In some embodiments, R 38 is independently -OCH 2 I. In some embodiments, R 38 is independently -OCH 2 F. In some embodiments, R 38 is independently -N 3 . In some embodiments, R 38 is independently –OCH 3 . In some embodiments, R 38 is independently –CH 3 . In some embodiments, R 38 is independently –CH 2 CH 3 . In some embodiments, R 38 is independently unsubstituted propyl. In some embodiments, R 38 is independently unsubstituted isopropyl. In some embodiments, R 38 is independently unsubstituted butyl. In some embodiments, R 38 is independently unsubstituted tert-butyl. In some embodiments, R 38 is independently –F. In some embodiments, R 38 is independently –C1. In some embodiments, R 38 is independently –Br. In some embodiments, R 38 is independently –I. [0385] In some embodiments, R 6A is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0386] In some embodiments, R 6B is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0387] In some embodiments, R 6C is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0388] In some embodiments, R 6D is independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0389] In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0390] In some embodiments, R 6A , R 6B , R 6C , and R 6D are independently hydrogen, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , R 36 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 36 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 36 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 36 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 36 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 36 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form an R 36 - substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl) or R 36 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form an R 36 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl. In some embodiments, R 6A and R 6B substituents bonded to the same nitrogen atom are independently joined to form an R 36 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0391] In some embodiments, R 6A is independently R 36 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6A is independently R 36 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6A is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6A is independently R 36 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6A is independently R 36 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6A is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6A is independently R 36 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6A is independently R 36 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6A is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6A is independently R 36 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6A is independently R 36 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6A is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6A is independently R 36 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6A is independently R 36 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6A is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6A is independently R 36 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6A is independently R 36 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6A is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0392] In some embodiments, R 6A is independently -CC1 3 . In some embodiments, R 6A is independently -CBr 3 . In some embodiments, R 6A is independently -CF 3 . In some embodiments, R 6A is independently -C1 3 . In some embodiments, R 6A is independently -CHC1 2 . In some embodiments, R 6A is independently -CHBr 2 . In some embodiments, R 6A is independently -CHF 2 . In some embodiments, R 6A is independently -CHI 2 . In some embodiments, R 6A is independently -CH 2 C1. In some embodiments, R 6A is independently -CH 2 Br. In some embodiments, R 6A is independently -CH 2 F. In some embodiments, R 6A is independently -CH 2 I. In some embodiments, R 6A is independently -CN. In some embodiments, R 6A is independently -OH. In some embodiments, R 6A is independently -COOH. In some embodiments, R 6A is independently -CONH 2 . In some embodiments, R 6A is independently -OCC1 3 . In some embodiments, R 6A is independently -OCF 3 . In some embodiments, R 6A is independently -OCBr 3 . In some embodiments, R 6A is independently -OC1 3 . In some embodiments, R 6A is independently -OCHC1 2 . In some embodiments, R 6A is independently -OCHBr 2 . In some embodiments, R 6A is independently -OCHI 2 . In some embodiments, R 6A is independently -OCHF 2 . In some embodiments, R 6A is independently -OCH 2 C1. In some embodiments, R 6A is independently -OCH 2 Br. In some embodiments, R 6A is independently -OCH 2 I. In some embodiments, R 6A is independently -OCH 2 F. In some embodiments, R 6A is independently –OCH 3 . In some embodiments, R 6A is independently – CH 3 . In some embodiments, R 6A is independently –CH 2 CH 3 . In some embodiments, R 6A is independently unsubstituted propyl. In some embodiments, R 6A is independently unsubstituted isopropyl. In some embodiments, R 6A is independently unsubstituted butyl. In some embodiments, R 6A is independently unsubstituted tert-butyl. In some embodiments, R 6A is independently hydrogen. [0393] In some embodiments, R 6B is independently R 36 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6B is independently R 36 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6B is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6B is independently R 36 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6B is independently R 36 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6B is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6B is independently R 36 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6B is independently R 36 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6B is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6B is independently R 36 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6B is independently R 36 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6B is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6B is independently R 36 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6B is independently R 36 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6B is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6B is independently R 36 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6B is independently R 36 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6B is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0394] In some embodiments, R 6B is independently -CC1 3 . In some embodiments, R 6B is independently -CBr 3 . In some embodiments, R 6B is independently -CF 3 . In some embodiments, R 6B is independently -C1 3 . In some embodiments, R 6B is independently -CHC1 2 . In some embodiments, R 6B is independently -CHBr 2 . In some embodiments, R 6B is independently -CHF 2 . In some embodiments, R 6B is independently -CHI 2 . In some embodiments, R 6B is independently -CH 2 C1. In some embodiments, R 6B is independently -CH 2 Br. In some embodiments, R 6B is independently -CH 2 F. In some embodiments, R 6B is independently -CH 2 I. In some embodiments, R 6B is independently -CN. In some embodiments, R 6B is independently -OH. In some embodiments, R 6B is independently -COOH. In some embodiments, R 6B is independently -CONH 2 . In some embodiments, R 6B is independently -OCC1 3 . In some embodiments, R 6B is independently -OCF 3 . In some embodiments, R 6B is independently -OCBr 3 . In some embodiments, R 6B is independently -OC1 3 . In some embodiments, R 6B is independently -OCHC1 2 . In some embodiments, R 6B is independently -OCHBr 2 . In some embodiments, R 6B is independently -OCHI 2 . In some embodiments, R 6B is independently -OCHF 2 . In some embodiments, R 6B is independently -OCH 2 C1. In some embodiments, R 6B is independently -OCH 2 Br. In some embodiments, R 6B is independently -OCH 2 I. In some embodiments, R 6B is independently -OCH 2 F. In some embodiments, R 6B is independently –OCH 3 . In some embodiments, R 6B is independently – CH 3 . In some embodiments, R 6B is independently –CH 2 CH 3 . In some embodiments, R 6B is independently unsubstituted propyl. In some embodiments, R 6B is independently unsubstituted isopropyl. In some embodiments, R 6B is independently unsubstituted butyl. In some embodiments, R 6B is independently unsubstituted tert-butyl. In some embodiments, R 6B is independently hydrogen. [0395] In some embodiments, R 6C is independently R 36 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6C is independently R 36 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6C is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6C is independently R 36 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6C is independently R 36 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6C is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6C is independently R 36 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6C is independently R 36 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6C is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6C is independently R 36 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6C is independently R 36 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6C is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6C is independently R 36 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6C is independently R 36 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6C is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6C is independently R 36 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6C is independently R 36 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6C is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0396] In some embodiments, R 6C is independently -CC1 3 . In some embodiments, R 6C is independently -CBr 3 . In some embodiments, R 6C is independently -CF 3 . In some embodiments, R 6C is independently -C1 3 . In some embodiments, R 6C is independently -CHC1 2 . In some embodiments, R 6C is independently -CHBr 2 . In some embodiments, R 6C is independently -CHF 2 . In some embodiments, R 6C is independently -CHI 2 . In some embodiments, R 6C is independently -CH 2 C1. In some embodiments, R 6C is independently -CH 2 Br. In some embodiments, R 6C is independently -CH 2 F. In some embodiments, R 6C is independently -CH 2 I. In some embodiments, R 6C is independently -CN. In some embodiments, R 6C is independently -OH. In some embodiments, R 6C is independently -COOH. In some embodiments, R 6C is independently -CONH 2 . In some embodiments, R 6C is independently -OCC1 3 . In some embodiments, R 6C is independently -OCF 3 . In some embodiments, R 6C is independently -OCBr 3 . In some embodiments, R 6C is independently -OC1 3 . In some embodiments, R 6C is independently -OCHC1 2 . In some embodiments, R 6C is independently -OCHBr 2 . In some embodiments, R 6C is independently -OCHI 2 . In some embodiments, R 6C is independently -OCHF 2 . In some embodiments, R 6C is independently -OCH 2 C1. In some embodiments, R 6C is independently -OCH 2 Br. In some embodiments, R 6C is independently -OCH 2 I. In some embodiments, R 6C is independently -OCH 2 F. In some embodiments, R 6C is independently –OCH 3 . In some embodiments, R 6C is independently –CH 3 . In some embodiments, R 6C is independently – CH 2 CH 3 . In some embodiments, R 6C is independently unsubstituted propyl. In some embodiments, R 6C is independently unsubstituted isopropyl. In some embodiments, R 6C is independently unsubstituted butyl. In some embodiments, R 6C is independently unsubstituted tert-butyl. In some embodiments, R 6C is independently hydrogen. [0397] In some embodiments, R 6D is independently R 36 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6D is independently R 36 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6D is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 6D is independently R 36 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6D is independently R 36 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6D is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 6D is independently R 36 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6D is independently R 36 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6D is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 6D is independently R 36 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6D is independently R 36 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6D is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 6D is independently R 36 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6D is independently R 36 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6D is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 6D is independently R 36 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6D is independently R 36 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 6D is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0398] In some embodiments, R 6D is independently -CC1 3 . In some embodiments, R 6D is independently -CBr 3 . In some embodiments, R 6D is independently -CF 3 . In some embodiments, R 6D is independently -C1 3 . In some embodiments, R 6D is independently -CHC1 2 . In some embodiments, R 6D is independently -CHBr 2 . In some embodiments, R 6D is independently -CHF 2 . In some embodiments, R 6D is independently -CHI 2 . In some embodiments, R 6D is independently -CH 2 C1. In some embodiments, R 6D is independently -CH 2 Br. In some embodiments, R 6D is independently -CH 2 F. In some embodiments, R 6D is independently -CH 2 I. In some embodiments, R 6D is independently -CN. In some embodiments, R 6D is independently -OH. In some embodiments, R 6D is independently -COOH. In some embodiments, R 6D is independently -CONH 2 . In some embodiments, R 6D is independently -OCC1 3 . In some embodiments, R 6D is independently -OCF 3 . In some embodiments, R 6D is independently -OCBr 3 . In some embodiments, R 6D is independently -OC1 3 . In some embodiments, R 6D is independently -OCHC1 2 . In some embodiments, R 6D is independently -OCHBr 2 . In some embodiments, R 6D is independently -OCHI 2 . In some embodiments, R 6D is independently -OCHF 2 . In some embodiments, R 6D is independently -OCH 2 C1. In some embodiments, R 6D is independently -OCH 2 Br. In some embodiments, R 6D is independently -OCH 2 I. In some embodiments, R 6D is independently -OCH 2 F. In some embodiments, R 6D is independently –OCH 3 . In some embodiments, R 6D is independently –CH 3 . In some embodiments, R 6D is independently – CH 2 CH 3 . In some embodiments, R 6D is independently unsubstituted propyl. In some embodiments, R 6D is independently unsubstituted isopropyl. In some embodiments, R 6D is independently unsubstituted butyl. In some embodiments, R 6D is independently unsubstituted tert-butyl. In some embodiments, R 6D is independently hydrogen. [0399] In some embodiments, L 5 is independently a bond, -S(O) 2 -, -S(O)-, =N-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 5 is a bond. In some embodiments, L 5 is independently a -S(O) 2 -. In some embodiments, L 5 is independently a -S(O)-. In some embodiments, L 5 is independently a -NH-. In some embodiments, L 5 is independently a -O-. In some embodiments, L 5 is independently a -S-. In some embodiments, L 5 is independently a -C(O)-. In some embodiments, L 5 is independently a -C(O)NH-. In some embodiments, L 5 is independently a -NHC(O)-. In some embodiments, L 5 is independently a -NHC(O)NH-. In some embodiments, L 5 is independently a -C(O)O-. In some embodiments, L 5 is independently -OC(O)-. In some embodiments, L 5 is independently a bond. In some embodiments, L 5 is independently -NR 5 -. In some embodiments, L 5 is independently =N-. In some embodiments, L 5 is independently -C(O)NR 5 -. In some embodiments, L 5 is independently -NR 5 C(O)-. In some embodiments, L 5 is independently -NR 5 C(O)NH-. In some embodiments, L 5 is independently -NHC(O)NR 5 -. [0400] In some embodiments, L 5 is substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 5 is substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 5 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 5 is substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 5 is substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 5 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 5 is substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 5 is substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 5 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 5 is substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 5 is substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 5 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 5 is substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 5 is substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 5 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 5 is substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 5 is substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 5 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0401] In some embodiments, L 5 is independently a bond, -S(O) 2 -, -S(O)-, =N-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, R 47 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), R 47 - substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), R 47 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), R 47 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), R 47 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or R 47 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 5 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, =N-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0402] In some embodiments, L 5 is R 47 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 5 is R 47 -substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 5 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 5 is R 47 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 5 is R 47 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 5 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 5 is R 47 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 5 is R 47 -substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 5 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 5 is R 47 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 5 is R 47 -substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 5 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 5 is R 47 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 5 is R 47 -substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 5 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 5 is R 47 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 5 is R 47 -substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 5 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0403] In some embodiments, R 47 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0404] In some embodiments, R 47 is independently oxo. In some embodiments, R 47 is independently halogen. In some embodiments, R 47 is independently -CC1 3 . In some embodiments, R 47 is independently -CBr 3 . In some embodiments, R 47 is independently -CF 3 . In some embodiments, R 47 is independently -C1 3 . In some embodiments, R 47 is independently -CHC1 2 . In some embodiments, R 47 is independently -CHBr 2 . In some embodiments, R 47 is independently -CHF 2 . In some embodiments, R 47 is independently -CHI 2 . In some embodiments, R 47 is independently -CH 2 C1. In some embodiments, R 47 is independently -CH 2 Br. In some embodiments, R 47 is independently -CH 2 F. In some embodiments, R 47 is independently -CH 2 I. In some embodiments, R 47 is independently -CN. In some embodiments, R 47 is independently -OH. In some embodiments, R 47 is independently -NH 2 . In some embodiments, R 47 is independently -COOH. In some embodiments, R 47 is independently -CONH 2 . In some embodiments, R 47 is independently -NO 2 . In some embodiments, R 47 is independently -SH. In some embodiments, R 47 is independently -SO 3 H. In some embodiments, R 47 is independently -SO 4 H. In some embodiments, R 47 is independently -SO 2 NH 2 . In some embodiments, R 47 is independently -NHNH 2 . In some embodiments, R 47 is independently -ONH 2 . In some embodiments, R 47 is independently -NHC(O)NHNH 2 . In some embodiments, R 47 is independently -NHC(O)NH 2 . In some embodiments, R 47 is independently -NHSO 2 H. In some embodiments, R 47 is independently -NHC(O)H. In some embodiments, R 47 is independently -NHC(O)OH. In some embodiments, R 47 is independently -NHOH. In some embodiments, R 47 is independently -OCC1 3 . In some embodiments, R 47 is independently -OCF 3 . In some embodiments, R 47 is independently -OCBr 3 . In some embodiments, R 47 is independently -OC1 3 . In some embodiments, R 47 is independently -OCHC1 2 . In some embodiments, R 47 is independently -OCHBr 2 . In some embodiments, R 47 is independently -OCHI 2 . In some embodiments, R 47 is independently -OCHF 2 . In some embodiments, R 47 is independently -OCH 2 C1. In some embodiments, R 47 is independently -OCH 2 Br. In some embodiments, R 47 is independently -OCH 2 I. In some embodiments, R 47 is independently -OCH 2 F. In some embodiments, R 47 is independently -N 3 . In some embodiments, R 47 is independently –OCH 3 . In some embodiments, R 47 is independently – CH 3 . In some embodiments, R 47 is independently –CH 2 CH 3 . In some embodiments, R 47 is independently unsubstituted propyl. In some embodiments, R 47 is independently unsubstituted isopropyl. In some embodiments, R 47 is independently unsubstituted butyl. In some embodiments, R 47 is independently unsubstituted tert-butyl. In some embodiments, R 47 is independently –F. In some embodiments, R 47 is independently –C1. In some embodiments, R 47 is independently –Br. In some embodiments, R 47 is independently –I. [0405] In some embodiments, L 6 is independently a bond, -S(O) 2 -, -S(O)-, =N-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 6 is a bond. In some embodiments, L 6 is independently a -S(O) 2 -. In some embodiments, L 6 is independently a -S(O)-. In some embodiments, L 6 is independently a -NH-. In some embodiments, L 6 is independently a -O-. In some embodiments, L 6 is independently a -S-. In some embodiments, L 6 is independently a -C(O)-. In some embodiments, L 6 is independently a -C(O)NH-. In some embodiments, L 6 is independently a -NHC(O)-. In some embodiments, L 6 is independently a -NHC(O)NH-. In some embodiments, L 6 is independently a -C(O)O-. In some embodiments, L 6 is independently -OC(O)-. In some embodiments, L 6 is independently a bond. In some embodiments, L 6 is independently -NR 6 -. In some embodiments, L 6 is independently =N-. In some embodiments, L 6 is independently -C(O)NR 6 -. In some embodiments, L 6 is independently -NR 6 C(O)-. In some embodiments, L 6 is independently -NR 6 C(O)NH-. In some embodiments, L 6 is independently -NHC(O)NR 6 -. [0406] In some embodiments, L 6 is substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 6 is substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 6 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 6 is substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 6 is substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 6 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 6 is substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 6 is substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 6 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 6 is substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 6 is substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 6 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 6 is substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 6 is substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 6 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 6 is substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 6 is substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 6 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0407] In some embodiments, L 6 is independently a bond, -S(O) 2 -, -S(O)-, =N-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, R 48 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), R 48 - substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), R 48 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), R 48 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), R 48 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or R 48 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 6 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, =N-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0408] In some embodiments, L 6 is R 48 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 6 is R 48 -substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 6 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 6 is R 48 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 6 is R 48 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 6 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 6 is R 48 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 6 is R 48 -substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 6 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 6 is R 48 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 6 is R 48 -substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 6 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 6 is R 48 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 6 is R 48 -substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 6 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 6 is R 48 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 6 is R 48 -substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 6 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0409] In some embodiments, R 48 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0410] In some embodiments, R 48 is independently oxo. In some embodiments, R 48 is independently halogen. In some embodiments, R 48 is independently -CC1 3 . In some embodiments, R 48 is independently -CBr 3 . In some embodiments, R 48 is independently -CF 3 . In some embodiments, R 48 is independently -C1 3 . In some embodiments, R 48 is independently -CHC1 2 . In some embodiments, R 48 is independently -CHBr 2 . In some embodiments, R 48 is independently -CHF 2 . In some embodiments, R 48 is independently -CHI 2 . In some embodiments, R 48 is independently -CH 2 C1. In some embodiments, R 48 is independently -CH 2 Br. In some embodiments, R 48 is independently -CH 2 F. In some embodiments, R 48 is independently -CH 2 I. In some embodiments, R 48 is independently -CN. In some embodiments, R 48 is independently -OH. In some embodiments, R 48 is independently -NH 2 . In some embodiments, R 48 is independently -COOH. In some embodiments, R 48 is independently -CONH 2 . In some embodiments, R 48 is independently -NO 2 . In some embodiments, R 48 is independently -SH. In some embodiments, R 48 is independently -SO 3 H. In some embodiments, R 48 is independently -SO 4 H. In some embodiments, R 48 is independently -SO 2 NH 2 . In some embodiments, R 48 is independently -NHNH 2 . In some embodiments, R 48 is independently -ONH 2 . In some embodiments, R 48 is independently -NHC(O)NHNH 2 . In some embodiments, R 48 is independently -NHC(O)NH 2 . In some embodiments, R 48 is independently -NHSO 2 H. In some embodiments, R 48 is independently -NHC(O)H. In some embodiments, R 48 is independently -NHC(O)OH. In some embodiments, R 48 is independently -NHOH. In some embodiments, R 48 is independently -OCC1 3 . In some embodiments, R 48 is independently -OCF 3 . In some embodiments, R 48 is independently -OCBr 3 . In some embodiments, R 48 is independently -OC1 3 . In some embodiments, R 48 is independently -OCHC1 2 . In some embodiments, R 48 is independently -OCHBr 2 . In some embodiments, R 48 is independently -OCHI 2 . In some embodiments, R 48 is independently -OCHF 2 . In some embodiments, R 48 is independently -OCH 2 C1. In some embodiments, R 48 is independently -OCH 2 Br. In some embodiments, R 48 is independently -OCH 2 I. In some embodiments, R 48 is independently -OCH 2 F. In some embodiments, R 48 is independently -N 3 . In some embodiments, R 48 is independently –OCH 3 . In some embodiments, R 48 is independently –CH 3 . In some embodiments, R 48 is independently –CH 2 CH 3 . In some embodiments, R 48 is independently unsubstituted propyl. In some embodiments, R 48 is independently unsubstituted isopropyl. In some embodiments, R 48 is independently unsubstituted butyl. In some embodiments, R 48 is independently unsubstituted tert-butyl. In some embodiments, R 48 is independently –F. In some embodiments, R 48 is independently –C1. In some embodiments, R 48 is independently –Br. In some embodiments, R 48 is independently –I. [0411] In some embodiments, X is independently –F. In some embodiments, X is independently –C1. In some embodiments, X is independently –Br. In some embodiments, X is independently –I. In some embodiments, X 1 is independently –F. In some embodiments, X 1 is independently –C1. In some embodiments, X 1 is independently –Br. In some embodiments, X 1 is independently –I. In some embodiments, X 2 is independently –F. In some embodiments, X 2 is independently –C1. In some embodiments, X 2 is independently –Br. In some embodiments, X 2 is independently –I. In some embodiments, X 3 is independently –F. In some embodiments, X 3 is independently –C1. In some embodiments, X 3 is independently –Br. In some embodiments, X 3 is independently –I. In some embodiments, X 4 is independently –F. In some embodiments, X 4 is independently –C1. In some embodiments, X 4 is independently –Br. In some embodiments, X 4 is independently –I. In some embodiments, X 5 is independently –F. In some embodiments, X 5 is independently –C1. In some embodiments, X 5 is independently –Br. In some embodiments, X 5 is independently –I. In some embodiments, X 6 is independently –F. In some embodiments, X 6 is independently –C1. In some embodiments, X 6 is independently –Br. In some embodiments, X 6 is independently –I. [0412] In some embodiments, n1 is independently 0. In some embodiments, n1 is independently 1. In some embodiments, n1 is independently 2. In some embodiments, n1 is independently 3. In some embodiments, n1 is independently 4. In some embodiments, n2 is independently 0. In some embodiments, n2 is independently 1. In some embodiments, n2 is independently 2. In some embodiments, n2 is independently 3. In some embodiments, n2 is independently 4. In some embodiments, n3 is independently 0. In some embodiments, n3 is independently 1. In some embodiments, n3 is independently 2. In some embodiments, n3 is independently 3. In some embodiments, n3 is independently 4. [0413] In some embodiments, m1 is independently 1. In some embodiments, m1 is independently 2. In some embodiments, m2 is independently 1. In some embodiments, m2 is independently 2. In some embodiments, m3 is independently 1. In some embodiments, m3 is independently 2. [0414] In some embodiments, v1 is independently 1. In some embodiments, v1 is independently 2. In some embodiments, v2 is independently 1. In some embodiments, v2 is independently 2. In some embodiments, v3 is independently 1. In some embodiments, v3 is independently 2. In some embodiments, z1 is independently 0. In some embodiments, z1 is independently 1. In some embodiments, z1 is independently 2. In some embodiments, z1 is independently 3. In some embodiments, z1 is independently 4. In some embodiments, z1 is independently 5. In some embodiments, z1 is independently 6. In some embodiments, z1 is independently 7. In some embodiments, z1 is independently 8. In some embodiments, z1 is independently 9. In some embodiments, z1 is independently 10. In some embodiments, z1 is independently 11. In some embodiments, z1 is independently 12. [0416] In some embodiments, z3 is independently 0. In some embodiments, z3 is independently 1. In some embodiments, z3 is independently 2. In some embodiments, z3 is independently 3. In some embodiments, z3 is independently 4. [0417] In some embodiments, Z is O, S, or SO 2 . In some embodiments, Z is O. In some embodiments, Z is S. In some embodiments, Z is SO 2 . [0418] In some embodiments, W is O, NH, NR 1 , or CH 2 . In some embodiments, W is O. In some embodiments, W is NH. In some embodiments, W is NR 1 . In some embodiments, W is CH 2 . It is understood that when W is CH 2 , W is optionally substituted by 1-2 R 1 substituents. In some embodiments, W is CHR 1 . In some embodiments, W is CR 1 R 1 . [0419] In some embodiments, n is 0 or 1. In some embodiments, n is 0. In some embodiments, n is 1. [0420] If a substituent (e.g., R 1 or R 3 ) is floating for a cycloalkyl ring, a heterocyclic ring, or an aromatic ring (e.g., aryl, heteroaryl, arylene, or heteroarylene), it is understood to obey the rules of chemical valency. [0421] A person of ordinary skill in the art will understand when a compound or a compound genus (e.g., a genus described herein) is described by a name or formula of a standalone compound with all valencies filled, the valencie(s) will be dictated by the context in which the compound is used. For example, when a compound (e.g., cellular component binder or targeted autophagy protein binder) as described herein is connected (e.g., bonded) through a linker, it is understood the compound represents a monovalent form of the standalone compound. The compounds provided herein may be depicted as standalone compounds with all valencies filled. However, when it is intended to be a monovalent compound (e.g., monovalent targeted autophagy protein binder) it is understood that a substituent (e.g., hydrogen, halogen, methyl, R 1 , R 2 , or R 3 ) may be removed to accommodate the linker. [0422] It is understood that when a compound as shown anywhere in the specification is connected (e.g., bonded) to another moiety through a linker, the compound is intended to be a monovalent form of the standalone compound at any attachment point following the replacement of a substituent (e.g., hydrogen or halogen) with a bond to the linker connected to the other moiety. [0423] It is understood that when a compound as shown anywhere in the specification (e.g., in Table 1) is connected (e.g., bonded) to a linker, it is understood the compound is intended to be a monovalent form of the standalone compound at any attachment point following the replacement of a substituent (e.g., hydrogen or halogen) with the bond to the linker. In some embodiments, the targeted autophagy binder is a compound in Table 1. In some embodiments, the monovalent targeted autophagy binder is a monovalent form of a compound in Table 1.
Table 1.
[0424] In some embodiments, the compound is a compound described herein. In some embodiments, the compound is a derivative, analogue, or prodrug of a compound described herein. In some embodiments, the compound is a derivative of a compound described herein. In some embodiments, the compound is an analogue of a compound described herein. In some embodiments, the compound is a prodrug of a compound described herein. [0425] It will be understood that unless stereochemistry is explicitly indicated in a chemical structure or name, the structure or name is intended to embrace all possible stereoisomers of a compound depicted. Similarly, if stereochemistry is explicity indicated in a chemical structure or name, it is understood that the present disclosure embraces all stereoisomers of the indicated compound unless indicated otherwise. [0426] In some embodiments, the targeted autophagy protein binder is capable of contacting an autophagy adapter protein. In some embodiments, the targeted autophagy binder is capable of binding (e.g., covalently binding) an autophagy adapter protein. In some embodiments, the monovalent targeted autophagy binder is capable of contacting an autophagy adapter protein. In some embodiments, the monovalent targeted autophagy binder is capable of binding (e.g., covalently binding) an autophagy adapter protein. [0427] In some embodiments, the targeted autophagy protein binder (e.g., autophagy adapter protein binder) is capable of contacting an autophagy adapter protein. In some embodiments, the monovalent targeted autophagy protein binder (e.g., monovalent autophagy adapter protein binder) is capable of contacting an autophagy adapter protein. In some embodiments, the autophagy adapter protein is p62/SQSTM1, or an analog, derivative, fragment, or homolog thereof. In some embodiments, the autophagy adapter protein is human p62/SQSTM1. [0428] In some embodiments, the targeted autophagy protein binder (e.g., autophagy adapter protein binder) is capable of contacting an amino acid corresponding to C26 of human p62/SQSTM1 protein. In some embodiments, the targeted autophagy protein binder (e.g., autophagy adapter protein binder) is capable of contacting an amino acid corresponding to C27 of human p62/SQSTM1protein. In some embodiments, the targeted autophagy protein binder (e.g., autophagy adapter protein binder) is capable of contacting an amino acid corresponding to C113 of human p62/SQSTM1 protein. In some embodiments, the monovalent targeted autophagy protein binder (e.g., monovalent autophagy adapter protein binder) is capable of contacting an amino acid corresponding to C26 of human p62/SQSTM1 protein. In some embodiments, the monovalent targeted autophagy protein binder (e.g., monovalent autophagy adapter protein binder) is capable of contacting an amino acid corresponding to C27 of human p62/SQSTM1protein. In some embodiments, the monovalent targeted autophagy protein binder (e.g., monovalent autophagy adapter protein binder) is capable of contacting an amino acid corresponding to C113 of human p62/SQSTM1 protein. [0429] In some embodiments, the targeted autophagy protein binder (e.g., autophagy adapter protein binder) is capable of forming a covalent bond with an amino acid corresponding to C26 of human p62/SQSTM1 protein. In some embodiments, the targeted autophagy protein binder (e.g., autophagy adapter protein binder) is capable of forming a covalent bond with an amino acid corresponding to C27 of human p62/SQSTM1protein. In some embodiments, the targeted autophagy protein binder (e.g., autophagy adapter protein binder) is capable of forming a covalent bond with an amino acid corresponding to C113 of human p62/SQSTM1 protein. In some embodiments, the monovalent targeted autophagy protein binder (e.g., monovalent autophagy adapter protein binder) is capable of forming a covalent bond with an amino acid corresponding to C26 of human p62/SQSTM1 protein. In some embodiments, the monovalent targeted autophagy protein binder (e.g., monovalent autophagy adapter protein binder) is capable of forming a covalent bond with an amino acid corresponding to C27 of human p62/SQSTM1protein. In some embodiments, the monovalent targeted autophagy protein binder (e.g., monovalent autophagy adapter protein binder) is capable of forming a covalent bond with an amino acid corresponding to C113 of human p62/SQSTM1protein. Linker [0430] In some embodiments, a divalent linker binds the monovalent cellular component binder to the monovalent targeted autophagy protein binder (e.g., monovalent autophagy adapter protein binder). It is understood that the monovalent cellular component binder is connected to the divalent linker at any position provided the resulting covalent bond is constructed according to the standard rules of chemical valency known in the chemical arts. It is understood that the monovalent targeted autophagy protein binder is connected to the divalent linker at any position provided the resulting covalent bond is constructed according to the standard rules of chemical valency known in the chemical arts. [0431] In some embodiments, the divalent linker has the formula -L 1 -L 2 -L 3 -L 4 -. [0432] In some embodiments, L 1 is connected directly to the monovalent targeted autophagy protein binder (e.g., monovalent autophagy adapter protein binder). In some embodiments, L 1 is -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a bioconugate linker. In some embodiments, L 1 is -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. In some embodiments, L 1 is a bioconjugate linker. [0433] In some embodiments, L 2 is a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a bioconjugate linker. In some embodiments, L 2 is a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. In some embodiments, L 2 is a bioconjugate linker. [0434] In some embodiments, L 3 is a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a bioconugate linker. In some embodiments, L 3 is a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. In some embodiments, L 3 is a bioconjugate linker. [0435] In some embodiments, L 4 is a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a bioconugate linker. In some embodiments, L 4 is a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene. In some embodiments, L 4 is a bioconjugate linker. [0436] In some embodiments, the divalent linker -L 1 -L 2 -L 3 -L 4 - has the formula -O-L 2 -L 3 -L 4 - and L 2 , L 3 , and L 4 are as described herein. In some embodiments, the divalent linker has the formula -O-L 2 -L 3 -O- and L 2 and L 3 are as described herein. In some embodiments, the divalent linker -L 1 -L 2 -L 3 -L 4 - has the formula -L 1 -L 2 -L 3 -O- and L 1 , L 2 , and L 3 are as described herein. In some embodiments, the divalent linker -L 1 -L 2 -L 3 -L 4 - has the formula -O-L 2 -L 3 -O-, L 2 is R 44 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), L 3 is R 45 -substituted or unsubstituted alkylene (e.g., C1- C8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), and R 44 and R 45 are as described herein. In some embodiments, the divalent linker -L 1 -L 2 -L 3 -L 4 - has the formula -O-L 2 -L 3 -O-, L 2 is unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), and L 3 is unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, the divalent linker -L 1 -L 2 -L 3 -L 4 - has the formula -O-L 2 -O-, L 2 is R 44 - substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), and R 44 is as described herein. In some embodiments, the divalent linker - L 1 -L 2 -L 3 -L 4 - has the formula -O-L 2 -L 3 -O-, L 3 is a bond, L 2 is unsubstituted alkylene (e.g., C 1 - C8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is R 44 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene); and R 44 is as described herein. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is R 44 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene); and R 44 is as described herein. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is R 44 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene); and R 44 is oxo. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 2 to 8 membered heteroalkylene. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 2 to 6 membered heteroalkylene. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 2 to 4 membered heteroalkylene. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 2 to 12 membered heteroalkylene. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 2 to 10 membered heteroalkylene. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 2 to 8 membered heteroalkylene. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 4 to 12 membered heteroalkylene. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 4 to 10 membered heteroalkylene. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 6 to 12 membered heteroalkylene. In some embodiments, of the divalent linker of formula -L 1 -L 2 -L 3 -L 4 -; L 1 , L 3 , and L 4 are a bond; L 2 is unsubstituted 8 to 12 membered heteroalkylene. [0437] In some embodiments, the linker is a linker described in US20160272639A1, WO 2 017079723A1, US20130190340A1, or WO 2 013106643A2 which are incorporated herein by reference in their entirety for all purposes. In some embodiments, the linker is , , In some embodiments, the linker [0438] In some embodiments, L 1 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 1 is independently a -S(O) 2 -. In some embodiments, L 1 is independently a -S(O)- . In some embodiments, L 1 is independently a -NH-. In some embodiments, L 1 is independently a -O-. In some embodiments, L 1 is independently a -S-. In some embodiments, L 1 is independently a -C(O)- . In some embodiments, L 1 is independently a -C(O)NH-. In some embodiments, L 1 is independently a -NHC(O)- . In some embodiments, L 1 is independently a -NHC(O)NH-. In some embodiments, L 1 is independently a -C(O)O-. In some embodiments, L 1 is independently -OC(O)-. [0439] In some embodiments, L 1 is substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 1 is substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 1 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 1 is substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 1 is substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 1 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 1 is substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 1 is substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 1 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 1 is substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 1 is substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 1 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 1 is substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 1 is substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 1 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 1 is substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 1 is substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 1 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0440] In some embodiments, L 1 is independently -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, R 43 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), R 43 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), R 43 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), R 43 - substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), R 43 - substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or R 43 - substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 1 is independently -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0441] In some embodiments, L 1 is R 43 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 1 is R 43 -substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 1 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 1 is R 43 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 1 is R 43 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 1 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 1 is R 43 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 1 is R 43 -substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 1 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 1 is R 43 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 1 is R 43 -substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 1 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 1 is R 43 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 1 is R 43 -substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 1 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 1 is R 43 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 1 is R 43 -substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 1 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0442] R 43 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0443] In some embodiments, R 43 is independently oxo. In some embodiments, R 43 is independently halogen. In some embodiments, R 43 is independently -CC1 3 . In some embodiments, R 43 is independently -CBr 3 . In some embodiments, R 43 is independently -CF 3 . In some embodiments, R 43 is independently -C1 3 . In some embodiments, R 43 is independently -CHC1 2 . In some embodiments, R 43 is independently -CHBr 2 . In some embodiments, R 43 is independently -CHF 2 . In some embodiments, R 43 is independently -CHI 2 . In some embodiments, R 43 is independently -CH 2 C1. In some embodiments, R 43 is independently -CH 2 Br. In some embodiments, R 43 is independently -CH 2 F. In some embodiments, R 43 is independently -CH 2 I. In some embodiments, R 43 is independently -CN. In some embodiments, R 43 is independently -OH. In some embodiments, R 43 is independently -NH 2 . In some embodiments, R 43 is independently -COOH. In some embodiments, R 43 is independently -CONH 2 . In some embodiments, R 43 is independently -NO 2 . In some embodiments, R 43 is independently -SH. In some embodiments, R 43 is independently -SO 3 H. In some embodiments, R 43 is independently -SO 4 H. In some embodiments, R 43 is independently -SO 2 NH 2 . In some embodiments, R 43 is independently -NHNH 2 . In some embodiments, R 43 is independently -ONH 2 . In some embodiments, R 43 is independently -NHC(O)NHNH 2 . In some embodiments, R 43 is independently -NHC(O)NH 2 . In some embodiments, R 43 is independently -NHSO 2 H. In some embodiments, R 43 is independently -NHC(O)H. In some embodiments, R 43 is independently -NHC(O)OH. In some embodiments, R 43 is independently -NHOH. In some embodiments, R 43 is independently -OCC1 3 . In some embodiments, R 43 is independently -OCF 3 . In some embodiments, R 43 is independently -OCBr 3 . In some embodiments, R 43 is independently -OC1 3 . In some embodiments, R 43 is independently -OCHC1 2 . In some embodiments, R 43 is independently -OCHBr 2 . In some embodiments, R 43 is independently -OCHI 2 . In some embodiments, R 43 is independently -OCHF 2 . In some embodiments, R 43 is independently -OCH 2 C1. In some embodiments, R 43 is independently -OCH 2 Br. In some embodiments, R 43 is independently -OCH 2 I. In some embodiments, R 43 is independently -OCH 2 F. In some embodiments, R 43 is independently -N 3 . In some embodiments, R 43 is independently –OCH 3 . In some embodiments, R 43 is independently – CH 3 . In some embodiments, R 43 is independently –CH 2 CH 3 . In some embodiments, R 43 is independently unsubstituted propyl. In some embodiments, R 43 is independently unsubstituted isopropyl. In some embodiments, R 43 is independently unsubstituted butyl. In some embodiments, R 43 is independently unsubstituted tert-butyl. In some embodiments, R 43 is independently –F. In some embodiments, R 43 is independently –C1. In some embodiments, R 43 is independently –Br. In some embodiments, R 43 is independently –I. [0444] In some embodiments, L 2 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 2 is independently a -S(O) 2 -. In some embodiments, L 2 is independently a -S(O)- . In some embodiments, L 2 is independently a -NH-. In some embodiments, L 2 is independently a -O-. In some embodiments, L 2 is independently a -S-. In some embodiments, L 2 is independently a -C(O)-. In some embodiments, L 2 is independently a -C(O)NH-. In some embodiments, L 2 is independently a -NHC(O)-. In some embodiments, L 2 is independently a -NHC(O)NH-. In some embodiments, L 2 is independently a -C(O)O-. In some embodiments, L 2 is independently -OC(O)-. In some embodiments, L 2 is independently a bond. [0445] In some embodiments, L 2 is substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 2 is substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 2 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 2 is substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 2 is substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 2 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 2 is substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 2 is substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 2 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 2 is substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 2 is substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 2 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 2 is substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 2 is substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 2 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 2 is substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 2 is substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 2 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0446] In some embodiments, L 2 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, R 44 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), R 44 - substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), R 44 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), R 44 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), R 44 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or R 44 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 2 is independently a bond, -S(O , -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0447] In some embodiments, L 2 is R 44 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 2 is R 44 -substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 2 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 2 is R 44 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 2 is R 44 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 2 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 2 is R 44 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 2 is R 44 -substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 2 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 2 is R 44 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 2 is R 44 -substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 2 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 2 is R 44 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 2 is R 44 -substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 2 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 2 is R 44 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 2 is R 44 -substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 2 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0448] R 44 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0449] In some embodiments, R 44 is independently oxo. In some embodiments, R 44 is independently halogen. In some embodiments, R 44 is independently -CC1 3 . In some embodiments, R 44 is independently -CBr 3 . In some embodiments, R 44 is independently -CF 3 . In some embodiments, R 44 is independently -C1 3 . In some embodiments, R 44 is independently -CHC1 2 . In some embodiments, R 44 is independently -CHBr 2 . In some embodiments, R 44 is independently -CHF 2 . In some embodiments, R 44 is independently -CHI 2 . In some embodiments, R 44 is independently -CH 2 C1. In some embodiments, R 44 is independently -CH 2 Br. In some embodiments, R 44 is independently -CH 2 F. In some embodiments, R 44 is independently -CH 2 I. In some embodiments, R 44 is independently -CN. In some embodiments, R 44 is independently -OH. In some embodiments, R 44 is independently -NH 2 . In some embodiments, R 44 is independently -COOH. In some embodiments, R 44 is independently -CONH 2 . In some embodiments, R 44 is independently -NO 2 . In some embodiments, R 44 is independently -SH. In some embodiments, R 44 is independently -SO 3 H. In some embodiments, R 44 is independently -SO 4 H. In some embodiments, R 44 is independently -SO 2 NH 2 . In some embodiments, R 44 is independently -NHNH 2 . In some embodiments, R 44 is independently -ONH 2 . In some embodiments, R 44 is independently -NHC(O)NHNH 2 . In some embodiments, R 44 is independently -NHC(O)NH 2 . In some embodiments, R 44 is independently -NHSO 2 H. In some embodiments, R 44 is independently -NHC(O)H. In some embodiments, R 44 is independently -NHC(O)OH. In some embodiments, R 44 is independently -NHOH. In some embodiments, R 44 is independently -OCC1 3 . In some embodiments, R 44 is independently -OCF 3 . In some embodiments, R 44 is independently -OCBr 3 . In some embodiments, R 44 is independently -OC1 3 . In some embodiments, R 44 is independently -OCHC1 2 . In some embodiments, R 44 is independently -OCHBr 2 . In some embodiments, R 44 is independently -OCHI 2 . In some embodiments, R 44 is independently -OCHF 2 . In some embodiments, R 44 is independently -OCH 2 C1. In some embodiments, R 44 is independently -OCH 2 Br. In some embodiments, R 44 is independently -OCH 2 I. In some embodiments, R 44 is independently -OCH 2 F. In some embodiments, R 44 is independently -N 3 . In some embodiments, R 44 is independently –OCH 3 . In some embodiments, R 44 is independently – CH 3 . In some embodiments, R 44 is independently –CH 2 CH 3 . In some embodiments, R 44 is independently unsubstituted propyl. In some embodiments, R 44 is independently unsubstituted isopropyl. In some embodiments, R 44 is independently unsubstituted butyl. In some embodiments, R 44 is independently unsubstituted tert-butyl. In some embodiments, R 44 is independently –F. In some embodiments, R 44 is independently –C1. In some embodiments, R 44 is independently –Br. In some embodiments, R 44 is independently –I. [0450] In some embodiments, L 3 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 3 is independently a -S(O) 2 -. In some embodiments, L 3 is independently a -S(O)- . In some embodiments, L 3 is independently a -NH-. In some embodiments, L 3 is independently a -O-. In some embodiments, L 3 is independently a -S-. In some embodiments, L 3 is independently a -C(O)-. In some embodiments, L 3 is independently a -C(O)NH-. In some embodiments, L 3 is independently a -NHC(O)-. In some embodiments, L 3 is independently a -NHC(O)NH-. In some embodiments, L 3 is independently a -C(O)O-. In some embodiments, L 3 is independently -OC(O)-. In some embodiments, L 3 is independently a bond. [0451] In some embodiments, L 3 is substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 3 is substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 3 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 3 is substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 3 is substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 3 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 3 is substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 3 is substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 3 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 3 is substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 3 is substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 3 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 3 is substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 3 is substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 3 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 3 is substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 3 is substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 3 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0452] In some embodiments, L 3 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, R 45 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), R 45 - substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), R 45 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), R 45 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), R 45 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or R 45 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 3 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0453] In some embodiments, L 3 is R 45 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 3 is R 45 -substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 3 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 3 is R 45 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 3 is R 45 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 3 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 3 is R 45 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 3 is R 45 -substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 3 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 3 is R 45 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 3 is R 45 -substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 3 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 3 is R 45 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 3 is R 45 -substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 3 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 3 is R 45 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 3 is R 45 -substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 3 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0454] In some embodiments, R 45 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0455] In some embodiments, R 45 is independently oxo. In some embodiments, R 45 is independently halogen. In some embodiments, R 45 is independently -CC1 3 . In some embodiments, R 45 is independently -CBr 3 . In some embodiments, R 45 is independently -CF 3 . In some embodiments, R 45 is independently -C1 3 . In some embodiments, R 45 is independently -CHC1 2 . In some embodiments, R 45 is independently -CHBr 2 . In some embodiments, R 45 is independently -CHF 2 . In some embodiments, R 45 is independently -CHI 2 . In some embodiments, R 45 is independently -CH 2 C1. In some embodiments, R 45 is independently -CH 2 Br. In some embodiments, R 45 is independently -CH 2 F. In some embodiments, R 45 is independently -CH 2 I. In some embodiments, R 45 is independently -CN. In some embodiments, R 45 is independently -OH. In some embodiments, R 45 is independently -NH 2 . In some embodiments, R 45 is independently -COOH. In some embodiments, R 45 is independently -CONH 2 . In some embodiments, R 45 is independently -NO 2 . In some embodiments, R 45 is independently -SH. In some embodiments, R 45 is independently -SO 3 H. In some embodiments, R 45 is independently -SO 4 H. In some embodiments, R 45 is independently -SO 2 NH 2 . In some embodiments, R 45 is independently -NHNH 2 . In some embodiments, R 45 is independently -ONH 2 . In some embodiments, R 45 is independently -NHC(O)NHNH 2 . In some embodiments, R 45 is independently -NHC(O)NH 2 . In some embodiments, R 45 is independently -NHSO 2 H. In some embodiments, R 45 is independently -NHC(O)H. In some embodiments, R 45 is independently -NHC(O)OH. In some embodiments, R 45 is independently -NHOH. In some embodiments, R 45 is independently -OCC1 3 . In some embodiments, R 45 is independently -OCF 3 . In some embodiments, R 45 is independently -OCBr 3 . In some embodiments, R 45 is independently -OC1 3 . In some embodiments, R 45 is independently -OCHC1 2 . In some embodiments, R 45 is independently -OCHBr 2 . In some embodiments, R 45 is independently -OCHI 2 . In some embodiments, R 45 is independently -OCHF 2 . In some embodiments, R 45 is independently -OCH 2 C1. In some embodiments, R 45 is independently -OCH 2 Br. In some embodiments, R 45 is independently -OCH 2 I. In some embodiments, R 45 is independently -OCH 2 F. In some embodiments, R 45 is independently -N 3 . In some embodiments, R 45 is independently –OCH 3 . In some embodiments, R 45 is independently – CH 3 . In some embodiments, R 45 is independently –CH 2 CH 3 . In some embodiments, R 45 is independently unsubstituted propyl. In some embodiments, R 45 is independently unsubstituted isopropyl. In some embodiments, R 45 is independently unsubstituted butyl. In some embodiments, R 45 is independently unsubstituted tert-butyl. In some embodiments, R 45 is independently –F. In some embodiments, R 45 is independently –C1. In some embodiments, R 45 is independently –Br. In some embodiments, R 45 is independently –I. [0456] In some embodiments, L 4 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 4 is independently a -S(O) 2 -. In some embodiments, L 4 is independently a -S(O)- . In some embodiments, L 4 is independently a -NH-. In some embodiments, L 4 is independently a -O-. In some embodiments, L 4 is independently a -S-. In some embodiments, L 4 is independently a -C(O)- . In some embodiments, L 4 is independently a -C(O)NH-. In some embodiments, L 4 is independently a -NHC(O)- . In some embodiments, L 4 is independently a -NHC(O)NH-. In some embodiments, L 4 is independently a -C(O)O-. In some embodiments, L 4 is independently -OC(O)-. In some embodiments, L 4 is independently a bond. [0457] In some embodiments, L 4 is substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 4 is substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 4 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 4 is substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 4 is substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 4 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 4 is substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 4 is substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 4 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 4 is substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 4 is substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 4 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 4 is substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 4 is substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 4 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 4 is substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 4 is substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 4 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0458] In some embodiments, L 4 is independently a bond, -S(O) 2 -, -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, R 46 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), R 46 - substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), R 46 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), R 46 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), R 46 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or R 46 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 4 is independently a bond, -S(O , -S(O)-, -NH-, -O-, -S-, -C(O)-, -C(O)NH-, -NHC(O)-, -NHC(O)NH-, -C(O)O-, -OC(O)-, unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene), unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene), unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene), unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene), unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene), or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0459] In some embodiments, L 4 is R 46 -substituted or unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 4 is R 46 -substituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 4 is an unsubstituted alkylene (e.g., C 1 -C 8 alkylene, C 1 -C 6 alkylene, or C 1 -C 4 alkylene). In some embodiments, L 4 is R 46 -substituted or unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 4 is R 46 -substituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 4 is an unsubstituted heteroalkylene (e.g., 2 to 8 membered heteroalkylene, 2 to 6 membered heteroalkylene, or 2 to 4 membered heteroalkylene). In some embodiments, L 4 is R 46 -substituted or unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 4 is R 46 -substituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 4 is an unsubstituted cycloalkylene (e.g., C 3 -C 8 cycloalkylene, C 3 -C 6 cycloalkylene, or C 5 -C 6 cycloalkylene). In some embodiments, L 4 is R 46 -substituted or unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 4 is R 46 -substituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 4 is an unsubstituted heterocycloalkylene (e.g., 3 to 8 membered heterocycloalkylene, 3 to 6 membered heterocycloalkylene, or 5 to 6 membered heterocycloalkylene). In some embodiments, L 4 is R 46 -substituted or unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 4 is R 46 -substituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 4 is an unsubstituted arylene (e.g., C 6 -C 10 arylene, C 10 arylene, or phenylene). In some embodiments, L 4 is R 46 -substituted or unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 4 is R 46 -substituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). In some embodiments, L 4 is an unsubstituted heteroarylene (e.g., 5 to 10 membered heteroarylene, 5 to 9 membered heteroarylene, or 5 to 6 membered heteroarylene). [0460] R 46 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0461] In some embodiments, R 46 is independently oxo. In some embodiments, R 46 is independently halogen. In some embodiments, R 46 is independently -CC1 3 . In some embodiments, R 46 is independently -CBr 3 . In some embodiments, R 46 is independently -CF 3 . In some embodiments, R 46 is independently -C1 3 . In some embodiments, R 46 is independently -CHC1 2 . In some embodiments, R 46 is independently -CHBr 2 . In some embodiments, R 46 is independently -CHF 2 . In some embodiments, R 46 is independently -CHI 2 . In some embodiments, R 46 is independently -CH 2 C1. In some embodiments, R 46 is independently -CH 2 Br. In some embodiments, R 46 is independently -CH 2 F. In some embodiments, R 46 is independently -CH 2 I. In some embodiments, R 46 is independently -CN. In some embodiments, R 46 is independently -OH. In some embodiments, R 46 is independently -NH 2 . In some embodiments, R 46 is independently -COOH. In some embodiments, R 46 is independently -CONH 2 . In some embodiments, R 46 is independently -NO 2 . In some embodiments, R 46 is independently -SH. In some embodiments, R 46 is independently -SO 3 H. In some embodiments, R 46 is independently -SO 4 H. In some embodiments, R 46 is independently -SO 2 NH 2 . In some embodiments, R 46 is independently -NHNH 2 . In some embodiments, R 46 is independently -ONH 2 . In some embodiments, R 46 is independently -NHC(O)NHNH 2 . In some embodiments, R 46 is independently -NHC(O)NH 2 . In some embodiments, R 46 is independently -NHSO 2 H. In some embodiments, R 46 is independently -NHC(O)H. In some embodiments, R 46 is independently -NHC(O)OH. In some embodiments, R 46 is independently -NHOH. In some embodiments, R 46 is independently -OCC1 3 . In some embodiments, R 46 is independently -OCF 3 . In some embodiments, R 46 is independently -OCBr 3 . In some embodiments, R 46 is independently -OC1 3 . In some embodiments, R 46 is independently -OCHC1 2 . In some embodiments, R 46 is independently -OCHBr 2 . In some embodiments, R 46 is independently -OCHI 2 . In some embodiments, R 46 is independently -OCHF 2 . In some embodiments, R 46 is independently -OCH 2 C1. In some embodiments, R 46 is independently -OCH 2 Br. In some embodiments, R 46 is independently -OCH 2 I. In some embodiments, R 46 is independently -OCH 2 F. In some embodiments, R 46 is independently -N 3 . In some embodiments, R 46 is independently –OCH 3 . In some embodiments, R 46 is independently – CH 3 . In some embodiments, R 46 is independently –CH 2 CH 3 . In some embodiments, R 46 is independently unsubstituted propyl. In some embodiments, R 46 is independently unsubstituted isopropyl. In some embodiments, R 46 is independently unsubstituted butyl. In some embodiments, R 46 is independently unsubstituted tert-butyl. In some embodiments, R 46 is independently –F. In some embodiments, R 46 is independently –C1. In some embodiments, R 46 is independently –Br. In some embodiments, R 46 is independently –I. Cellular Component Binder [0462] In some embodiments, the cellular component binder is a compound described herein. In some embodiments, the cellular component binder is an oligonucleotide (e.g., DNA, RNA, or siRNA), protein (e.g., antibody or antibody fragment), or compound (e.g., compound described herein). [0463] In some embodiments, the cellular component is a protein, ion, lipid, nucleic acid, nucleotide, amino acid, protein, particle, organelle, cellular compartment, microorganism, virus, lipid droplet, vesicle, small molecule, protein complex, protein aggregate, or macromolecule. In some embodiments, the cellular component is a protein. In some embodiments, the cellular component is an ion. In some embodiments, the cellular component is a lipid. In some embodiments, the cellular component is a nucleic acid. In some embodiments, the cellular component is a nucleotide. In some embodiments, the cellular component is an amino acid. In some embodiments, the cellular component is a protein. In some embodiments, the cellular component is a particle. In some embodiments, the cellular component is an organelle. In some embodiments, the cellular component is a cellular compartment. In some embodiments, the cellular component is a microorganism. In some embodiments, the cellular component is a vesicle. In some embodiments, the cellular component is a small molecule. In some embodiments, the cellular component is a protein complex. In some embodiments, the cellular component is a protein aggregate. In some embodiments, the cellular component is a macromolecule. In some embodiments, the cellular component is a lipid droplet. In some embodiments, the cellular component is a virus. [0464] In some embodiments, the compound including a monovalent cellular component binder covalently bound to a monovalent targeted autophagy protein binder, includes a plurality of optionally different monovalent targeted autophagy protein binders. [0465] In some embodiments, the cellular component is a ion (e.g., Na + , Mg + , Cu + , Cu 2+ , Zn 2+ , Mn 2+ , Fe 2+ , and Co 2+ ). In some embodiments, the cellular component is a polysaccharide. In some embodiments, the cellular component is a lipid (e.g., fats, waxes, sterols, fat-soluble vitamins such as vitamins A, D, E, and K, monoglycerides, diglycerides, triglycerides, or phospholipids). In some embodiments, the cellular component is a nucleic acid (e.g., DNA or RNA). In some embodiments, the cellular component is a nucleotide. In some embodiments, the cellular component is an amino acid. In some embodiments, the cellular component is a particle (e.g., nanoparticle). In some embodiments, the cellular component is a plurality of fiber (e.g., asbestos fibers). In some embodiments, the cellular component is an organelle (e.g., mitochondria, peroxisome, plastid, endoplasmic reticulum, flagellum, or Golgi apparatus). In some embodiments, the cellular component is a cellular compartment. In some embodiments, the cellular component is a microorganism (e.g., bacterium, virus, or fungus). In some embodiments, the cellular component is a virus. In some embodiments, the cellular component is a vesicle (e.g., lysosome, peroxisome). In some embodiments, the cellular component is a small molecule. In some embodiments, the cellular component is a protein complex. In some embodiments, the cellular component is a protein aggregate. In some embodiments, the cellular component is a macromolecule. In some embodiments, the cellular component is a biomolecule. In some embodiments, the cellular component is a protein aggregate, soluble protein, midbody ring, damaged mitochodria, peroxisomes, intracellular bacteria, phagocytic membrane remnants, or viral capsid proteins. In some embodiments, the cellular component is a misfolded protein. [0466] In some embodiments, the monovalent cellular component binder is a substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl. [0467] In some embodiments, the monovalent cellular component binder is a substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0468] In some embodiments, the monovalent cellular component binder is a substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, the monovalent cellular component binder is a substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, the monovalent cellular component binder is an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, the monovalent cellular component binder is a substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, the monovalent cellular component binder is a substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, the monovalent cellular component binder is an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, the monovalent cellular component binder is a substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, the monovalent cellular component binder is a substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, the monovalent cellular component binder is an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, the monovalent cellular component binder is a substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, the monovalent cellular component binder is a substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, the monovalent cellular component binder is an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, the monovalent cellular component binder is a substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, the monovalent cellular component binder is a substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, the monovalent cellular component binder is an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, the monovalent cellular component binder is a substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, the monovalent cellular component binder is a substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, the monovalent cellular component binder is an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0469] In some embodiments, the monovalent cellular component binder is a R 49 - substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 49 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 49 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 49 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 49 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 49 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, the monovalent cellular component binder is an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0470] In some embodiments, the monovalent cellular component binder is a R 49 - substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted alkyl (e.g., C 1 - C8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, the monovalent cellular component binder is an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, the monovalent cellular component binder is an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, the monovalent cellular component binder is an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, the monovalent cellular component binder is an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted or unsubstituted aryl (e.g., C 6 - C 10 aryl, C 10 aryl, or phenyl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, the monovalent cellular component binder is an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, the monovalent cellular component binder is a R 49 - substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, the monovalent cellular component binder is a R 49 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, the monovalent cellular component binder is an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0471] In some embodiments, R 49 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 50 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 50 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 50 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 50 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 50 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 50 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 49 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0472] In some embodiments, R 49 is independently oxo. In some embodiments, R 49 is independently halogen. In some embodiments, R 49 is independently -CC1 3 . In some embodiments, R 49 is independently -CBr 3 . In some embodiments, R 49 is independently -CF 3 . In some embodiments, R 49 is independently -C1 3 . In some embodiments, R 49 is independently -CHC1 2 . In some embodiments, R 49 is independently -CHBr 2 . In some embodiments, R 49 is independently -CHF 2 . In some embodiments, R 49 is independently -CHI 2 . In some embodiments, R 49 is independently -CH 2 C1. In some embodiments, R 49 is independently -CH 2 Br. In some embodiments, R 49 is independently -CH 2 F. In some embodiments, R 49 is independently -CH 2 I. In some embodiments, R 49 is independently -CN. In some embodiments, R 49 is independently -OH. In some embodiments, R 49 is independently -NH 2 . In some embodiments, R 49 is independently -COOH. In some embodiments, R 49 is independently -CONH 2 . In some embodiments, R 49 is independently -NO 2 . In some embodiments, R 49 is independently -SH. In some embodiments, R 49 is independently -SO 3 H. In some embodiments, R 49 is independently -SO 4 H. In some embodiments, R 49 is independently -SO 2 NH 2 . In some embodiments, R 49 is independently -NHNH 2 . In some embodiments, R 49 is independently -ONH 2 . In some embodiments, R 49 is independently -NHC(O)NHNH 2 . In some embodiments, R 49 is independently -NHC(O)NH 2 . In some embodiments, R 49 is independently -NHSO 2 H. In some embodiments, R 49 is independently -NHC(O)H. In some embodiments, R 49 is independently -NHC(O)OH. In some embodiments, R 49 is independently -NHOH. In some embodiments, R 49 is independently -OCC1 3 . In some embodiments, R 49 is independently -OCF 3 . In some embodiments, R 49 is independently -OCBr 3 . In some embodiments, R 49 is independently -OC1 3 . In some embodiments, R 49 is independently -OCHC1 2 . In some embodiments, R 49 is independently -OCHBr 2 . In some embodiments, R 49 is independently -OCHI 2 . In some embodiments, R 49 is independently -OCHF 2 . In some embodiments, R 49 is independently -OCH 2 C1. In some embodiments, R 49 is independently -OCH 2 Br. In some embodiments, R 49 is independently -OCH 2 I. In some embodiments, R 49 is independently -OCH 2 F. In some embodiments, R 49 is independently -N 3 . In some embodiments, R 49 is independently –OCH 3 . In some embodiments, R 49 is independently –CH 3 . In some embodiments, R 49 is independently –CH 2 CH 3 . In some embodiments, R 49 is independently unsubstituted propyl. In some embodiments, R 49 is independently unsubstituted isopropyl. In some embodiments, R 49 is independently unsubstituted butyl. In some embodiments, R 49 is independently unsubstituted tert-butyl. In some embodiments, R 49 is independently –F. In some embodiments, R 49 is independently –C1. In some embodiments, R 49 is independently –Br. In some embodiments, R 49 is independently –I. [0473] In some embodiments, R 49 is independently R 50 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 49 is independently R 50 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 49 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 49 is independently R 50 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 49 is independently R 50 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 49 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 49 is independently R 50 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 49 is independently R 50 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 49 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 49 is independently R 50 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 49 is independently R 50 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 49 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 49 is independently R 50 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 49 is independently R 50 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 49 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 49 is independently R 50 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 49 is independently R 50 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 49 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0474] In some embodiments, R 50 is independently oxo, halogen, -CC1 3 , -CBr 3 , -CF 3 , -C1 3 , -CHC1 2 , -CHBr 2 , -CHF 2 , -CHI 2 , -CH 2 C1, -CH 2 Br, -CH 2 F, -CH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , -NHC(O)NH 2 , -NHSO 2 H, -NHC(O)H, -NHC(O)OH, -NHOH, -OCC1 3 , -OCF 3 , -OCBr 3 , -OC1 3 , -OCHC1 2 , -OCHBr 2 , -OCHI 2 , -OCHF 2 , -OCH 2 C1, -OCH 2 Br, -OCH 2 I, -OCH 2 F, -N 3 , R 51 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), R 51 - substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), R 51 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), R 51 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), R 51 -substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or R 51 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 50 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0475] In some embodiments, R 50 is independently R 51 -substituted or unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 50 is independently R 51 -substituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 50 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 50 is independently R 51 -substituted or unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 50 is independently R 51 -substituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 50 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 50 is independently R 51 -substituted or unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 50 is independently R 51 -substituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 50 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 50 is independently R 51 -substituted or unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 50 is independently R 51 -substituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 50 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 50 is independently R 51 - substituted or unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 50 is independently R 51 -substituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 50 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 50 is independently R 51 -substituted or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 50 is independently R 51 -substituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). In some embodiments, R 50 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0476] In some embodiments, R 50 is independently oxo. In some embodiments, R 50 is independently halogen. In some embodiments, R 50 is independently -CC1 3 . In some embodiments, R 50 is independently -CBr 3 . In some embodiments, R 50 is independently -CF 3 . In some embodiments, R 50 is independently -C1 3 . In some embodiments, R 50 is independently -CHC1 2 . In some embodiments, R 50 is independently -CHBr 2 . In some embodiments, R 50 is independently -CHF 2 . In some embodiments, R 50 is independently -CHI 2 . In some embodiments, R 50 is independently -CH 2 C1. In some embodiments, R 50 is independently -CH 2 Br. In some embodiments, R 50 is independently -CH 2 F. In some embodiments, R 50 is independently -CH 2 I. In some embodiments, R 50 is independently -CN. In some embodiments, R 50 is independently -OH. In some embodiments, R 50 is independently -NH 2 . In some embodiments, R 50 is independently -COOH. In some embodiments, R 50 is independently -CONH 2 . In some embodiments, R 50 is independently -NO 2 . In some embodiments, R 50 is independently -SH. In some embodiments, R 50 is independently -SO 3 H. In some embodiments, R 50 is independently -SO 4 H. In some embodiments, R 50 is independently -SO 2 NH 2 . In some embodiments, R 50 is independently -NHNH 2 . In some embodiments, R 50 is independently -ONH 2 . In some embodiments, R 50 is independently -NHC(O)NHNH 2 . In some embodiments, R 50 is independently -NHC(O)NH 2 . In some embodiments, R 50 is independently -NHSO 2 H. In some embodiments, R 50 is independently -NHC(O)H. In some embodiments, R 50 is independently -NHC(O)OH. In some embodiments, R 50 is independently -NHOH. In some embodiments, R 50 is independently -OCC1 3 . In some embodiments, R 50 is independently -OCF 3 . In some embodiments, R 50 is independently -OCBr 3 . In some embodiments, R 50 is independently -OC1 3 . In some embodiments, R 50 is independently -OCHC1 2 . In some embodiments, R 50 is independently -OCHBr 2 . In some embodiments, R 50 is independently -OCHI 2 . In some embodiments, R 50 is independently -OCHF 2 . In some embodiments, R 50 is independently -OCH 2 C1. In some embodiments, R 50 is independently -OCH 2 Br. In some embodiments, R 50 is independently -OCH 2 I. In some embodiments, R 50 is independently -OCH 2 F. In some embodiments, R 50 is independently -N 3 . In some embodiments, R 50 is independently –OCH 3 . In some embodiments, R 50 is independently –CH 3 . In some embodiments, R 50 is independently –CH 2 CH 3 . In some embodiments, R 50 is independently unsubstituted propyl. In some embodiments, R 50 is independently unsubstituted isopropyl. In some embodiments, R 50 is independently unsubstituted butyl. In some embodiments, R 50 is independently unsubstituted tert-butyl. In some embodiments, R 50 is independently –F. In some embodiments, R 50 is independently –C1. In some embodiments, R 50 is independently –Br. In some embodiments, R 50 is independently –I. [0477] In some embodiments, R 51 is independently oxo, halogen, -CF 3 , -CBr 3 , -CC1 3 , -C1 3 , -CHF 2 , -CHBr 2 , -CHC1 2 , -CHI 2 , -CH 2 F, -CH 2 Br, -CH 2 C1, -CH 2 I, -OCF 3 , -OCBr 3 , -OCC1 3 , -OC1 3 , -OCHF 2 , -OCHBr 2 , -OCHC1 2 , -OCHI 2 , -OCH 2 F, -OCH 2 Br, -OCH 2 C1, -OCH 2 I, -CN, -OH, -NH 2 , -COOH, -CONH 2 , -NO 2 , -SH, -SO 3 H, -SO 4 H, -SO 2 NH 2 , -NHNH 2 , -ONH 2 , -NHC(O)NHNH 2 , unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl), unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl), unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl), unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl), unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl), or unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0478] In some embodiments, R 51 is independently an unsubstituted alkyl (e.g., C 1 -C 8 alkyl, C 1 -C 6 alkyl, or C 1 -C 4 alkyl). In some embodiments, R 51 is independently an unsubstituted heteroalkyl (e.g., 2 to 8 membered heteroalkyl, 2 to 6 membered heteroalkyl, or 2 to 4 membered heteroalkyl). In some embodiments, R 51 is independently an unsubstituted cycloalkyl (e.g., C 3 -C 8 cycloalkyl, C 3 -C 6 cycloalkyl, or C 5 -C 6 cycloalkyl). In some embodiments, R 51 is independently an unsubstituted heterocycloalkyl (e.g., 3 to 8 membered heterocycloalkyl, 3 to 6 membered heterocycloalkyl, or 5 to 6 membered heterocycloalkyl). In some embodiments, R 51 is independently an unsubstituted aryl (e.g., C 6 -C 10 aryl, C 10 aryl, or phenyl). In some embodiments, R 51 is independently an unsubstituted heteroaryl (e.g., 5 to 10 membered heteroaryl, 5 to 9 membered heteroaryl, or 5 to 6 membered heteroaryl). [0479] In some embodiments, R 51 is independently oxo. In some embodiments, R 51 is independently halogen. In some embodiments, R 51 is independently -CC1 3 . In some embodiments, R 51 is independently -CBr 3 . In some embodiments, R 51 is independently -CF 3 . In some embodiments, R 51 is independently -C1 3 . In some embodiments, R 51 is independently -CHC1 2 . In some embodiments, R 51 is independently -CHBr 2 . In some embodiments, R 51 is independently -CHF 2 . In some embodiments, R 51 is independently -CHI 2 . In some embodiments, R 51 is independently -CH 2 C1. In some embodiments, R 51 is independently -CH 2 Br. In some embodiments, R 51 is independently -CH 2 F. In some embodiments, R 51 is independently -CH 2 I. In some embodiments, R 51 is independently -CN. In some embodiments, R 51 is independently -OH. In some embodiments, R 51 is independently -NH 2 . In some embodiments, R 51 is independently -COOH. In some embodiments, R 51 is independently -CONH 2 . In some embodiments, R 51 is independently -NO 2 . In some embodiments, R 51 is independently -SH. In some embodiments, R 51 is independently -SO 3 H. In some embodiments, R 51 is independently -SO 4 H. In some embodiments, R 51 is independently -SO 2 NH 2 . In some embodiments, R 51 is independently -NHNH 2 . In some embodiments, R 51 is independently -ONH 2 . In some embodiments, R 51 is independently -NHC(O)NHNH 2 . In some embodiments, R 51 is independently -NHC(O)NH 2 . In some embodiments, R 51 is independently -NHSO 2 H. In some embodiments, R 51 is independently -NHC(O)H. In some embodiments, R 51 is independently -NHC(O)OH. In some embodiments, R 51 is independently -NHOH. In some embodiments, R 51 is independently -OCC1 3 . In some embodiments, R 51 is independently -OCF 3 . In some embodiments, R 51 is independently -OCBr 3 . In some embodiments, R 51 is independently -OC1 3 . In some embodiments, R 51 is independently -OCHC1 2 . In some embodiments, R 51 is independently -OCHBr 2 . In some embodiments, R 51 is independently -OCHI 2 . In some embodiments, R 51 is independently -OCHF 2 . In some embodiments, R 51 is independently -OCH 2 C1. In some embodiments, R 51 is independently -OCH 2 Br. In some embodiments, R 51 is independently -OCH 2 I. In some embodiments, R 51 is independently -OCH 2 F. In some embodiments, R 51 is independently -N 3 . In some embodiments, R 51 is independently –OCH 3 . In some embodiments, R 51 is independently –CH 3 . In some embodiments, R 51 is independently –CH 2 CH 3 . In some embodiments, R 51 is independently unsubstituted propyl. In some embodiments, R 51 is independently unsubstituted isopropyl. In some embodiments, R 51 is independently unsubstituted butyl. In some embodiments, R 51 is independently unsubstituted tert-butyl. In some embodiments, R 51 is independently –F. In some embodiments, R 51 is independently –C1. In some embodiments, R 51 is independently –Br. In some embodiments, R 51 is independently –I. [0480] In some embodiments, the monovalent cellular component binder is capable of binding the protein BRD4. In some embodiments, the monovalent cellular component binder is capable of binding the protein thioflavin T. In some embodiments, the monovalent cellular component binder is capable of binding the protein amyloid beta plaques. In some embodiments, the monovalent cellular component binder is capable of binding Bromodomain-containing protein 4 (BRD4), KRAS, Myc proto-oncogene protein (MYC), yes-associated protein 1 (YAP), tafazzin (TAZ), Catenin beta-1 (CTNNB1), Amyloid precursor protein (APP), huntingtin protein (HTT), Alpha-synuclein (SNCA), Nuclear factor (erythroid-derived 2)-like 2 (NRF2), or microtubule-associated protein tau (MAPT). In some embodiments, the monovalent cellular component binder is capable of binding a protein aggregate (e.g., HTT, APP, SNCA, or MAPT). In some embodiments, the monovalent cellular component binder is capable of binding PTEN-induced putative kinase 1 (PINK1), Autophagy-related protein 32 (ATG32); Extended synaptotagmin-1 (ESYT1), Extended synaptotagmin-2 (ESYT2), Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3), Ras-related protein Rab-10 (RAB10), or Adipose triglyceride lipase (ATGL). In some embodiments, the monovalent cellular component binder is capable of binding a microorganism. In some embodiments, the monovalent cellular component binder is capable of binding a virus. In some embodiments, the monovalent cellular component binder is capable of binding a lipid droplet. In some embodiments, the monovalent cellular component binder is capable of binding a bacterial cell-surface glycan or bacterial cell surface protein. [0481] In some embodiments, the protein aggregate is Beta amyloid, Amyloid precursor protein, IAPP (Amylin), Alpha-synuclein, PrPSc, PrPSc, Huntingtin, Calcitonin, Atrial natriuretic factor, Apolipoprotein AI, Serum amyloid A, Medin, Prolactin, Transthyretin, Lysozyme, Beta-2 microglobulin, Gelsolin, Keratoepithelin, Beta amyloid, Cystatin, Immunoglobulin light chain AL, or S-IBM. [0482] In some embodiments, the protein aggregate includes Beta amyloid, Amyloid precursor protein, IAPP (Amylin), Alpha-synuclein, PrPSc, PrPSc, Huntingtin, Calcitonin, Atrial natriuretic factor, Apolipoprotein AI, Serum amyloid A, Medin, Prolactin, Transthyretin, Lysozyme, Beta-2 microglobulin, Gelsolin, Keratoepithelin, Beta amyloid, Cystatin, Immunoglobulin light chain AL, or S-IBM. [0483] In some embodiments, the protein aggregate includes Beta amyloid. In some embodiments, the protein aggregate includes Amyloid precursor protein. In some embodiments, the protein aggregate includes IAPP (Amylin). In some embodiments, the protein aggregate includes Alpha-synuclein. In some embodiments, the protein aggregate includes PrPSc. In some embodiments, the protein aggregate includes PrPSc. In some embodiments, the protein aggregate includes Huntingtin. In some embodiments, the protein aggregate includes Calcitonin. In some embodiments, the protein aggregate includes Atrial natriuretic factor. In some embodiments, the protein aggregate includes Apolipoprotein AI. In some embodiments, the protein aggregate includes Serum amyloid A. In some embodiments, the protein aggregate includes Medin. In some embodiments, the protein aggregate includes Prolactin. In some embodiments, the protein aggregate includes Transthyretin. In some embodiments, the protein aggregate includes Lysozyme. In some embodiments, the protein aggregate includes Beta-2 microglobulin. In some embodiments, the protein aggregate includes Gelsolin. In some embodiments, the protein aggregate includes Keratoepithelin. In some embodiments, the protein aggregate includes Beta amyloid. In some embodiments, the protein aggregate includes Cystatin. In some embodiments, the protein aggregate includes Immunoglobulin light chain AL. In some embodiments, the protein aggregate includes S-IBM. [0484] In some embodiments, the protein aggregate is Beta amyloid. In some embodiments, the protein aggregate is Amyloid precursor protein. In some embodiments, the protein aggregate is IAPP (Amylin). In some embodiments, the protein aggregate is Alpha- synuclein. In some embodiments, the protein aggregate is PrPSc. In some embodiments, the protein aggregate is PrPSc. In some embodiments, the protein aggregate is Huntingtin. In some embodiments, the protein aggregate is Calcitonin. In some embodiments, the protein aggregate is Atrial natriuretic factor. In some embodiments, the protein aggregate is Apolipoprotein AI. In some embodiments, the protein aggregate is Serum amyloid A. In some embodiments, the protein aggregate is Medin. In some embodiments, the protein aggregate is Prolactin. In some embodiments, the protein aggregate is Transthyretin. In some embodiments, the protein aggregate is Lysozyme. In some embodiments, the protein aggregate is Beta-2 microglobulin. In some embodiments, the protein aggregate is Gelsolin. In some embodiments, the protein aggregate is Keratoepithelin. In some embodiments, the protein aggregate is Beta amyloid. In some embodiments, the protein aggregate is Cystatin. In some embodiments, the protein aggregate is Immunoglobulin light chain AL. In some embodiments, the protein aggregate is S-IBM. [0485] In some embodiments, the protein aggregate is a huntingtin aggregate. In some embodiments, the protein aggregate is a polyQ huntingtin aggregate. [0486] In some embodiments, the monovalent cellular component binder is capable of binding a protein aggregate. In some embodiments, the monovalent cellular component binder is capable of binding a huntingtin aggregate. In some embodiments, the monovalent cellular component binder is capable of binding a polyQ huntingtin aggregate. [0487] In some embodiments, the monovalent cellular component binder is capable of binding BRD4. In some embodiments, the monovalent cellular component binder is capable of binding KRAS. In some embodiments, the monovalent cellular component binder is capable of binding MYC. In some embodiments, the monovalent cellular component binder is capable of binding YAP. In some embodiments, the monovalent cellular component binder is capable of binding TAZ. In some embodiments, the monovalent cellular component binder is capable of binding CTNNB1. In some embodiments, the monovalent cellular component binder is capable of binding APP. In some embodiments, the monovalent cellular component binder is capable of binding HTT. In some embodiments, the monovalent cellular component binder is capable of binding SNCA. In some embodiments, the monovalent cellular component binder is capable of binding NRF2. In some embodiments, the monovalent cellular component binder is capable of binding or MAPT. [0488] In some embodiments, the monovalent cellular component binder is capable of binding HTT. In some embodiments, the monovalent cellular component binder is capable of binding APP. In some embodiments, the monovalent cellular component binder is capable of binding SNCA. In some embodiments, the monovalent cellular component binder is capable of binding MAPT. In some embodiments, the monovalent cellular component binder is capable of binding PINK1. In some embodiments, the monovalent cellular component binder is capable of binding ATG32. In some embodiments, the monovalent cellular component binder is capable of binding ESYT. In some embodiments, the monovalent cellular component binder is capable of binding PI3KC3. In some embodiments, the monovalent cellular component binder is capable of binding RAB10. In some embodiments, the monovalent cellular component binder is capable of binding or ATGL. [0489] In some embodiments, the monovalent cellular component binder has the formula: . [0490] In some embodiments, the monovalent cellular component binder is capable of binding a protein aggregate. In some embodiments, the monovalent cellular component binder has the formula: [0491] In some embodiments, the monovalent cellular component binder is capable of binding a protein aggregate. In some embodiments, the monovalent cellular component binder is a monovalent form of thioflavin or a derivative thereof. In some embodiments, the monovalent cellular component binder has the formula: or . [0492] In some embodiments, the monovalent cellular component binder is capable of binding a protein aggregate. In some embodiments, the monovalent cellular component binder is a monovalent form of thioflavin or a derivative thereof. In some embodiments, the monovalent cellular component binder is a monovalent form of the formula: . [0493] In some embodiments, the monovalent cellular component binder is capable of binding a protein aggregate. In some embodiments, the monovalent cellular component binder has the formula: . Autophagy Adapter Protein [0494] In another aspect, provided herein an autophagy adapter protein (e.g., p62) covalently bonded to a compound described herein. In some embodiments, the compound is covalently bonded to a cysteine residue of the protein. In some embodiments, the compound is irreversibly covalently bonded to a cysteine residue of the protein. In some embodiments, the compound is a targeted autophagy degrader (e.g., as described herein), for example a compound including a monovalent cellular component binder (e.g., as described herein) and a monovalent autophagy adapter protein binder (e.g., as described herein). [0495] In some embodiments, the compound is covalently (e.g., irreversibly) bonded to an amino acid corresponding to C26 of human p62/SQSTM1 protein. In some embodiments, the compound is covalently (e.g., irreversibly) bonded to an amino acid corresponding to C27 of human p62/SQSTM1protein. In some embodiments, the compound is covalently (e.g., irreversibly) bonded to an amino acid corresponding to C113 of human p62/SQSTM1protein. [0496] In another aspect, provided herein is an autophagy adapter protein (e.g., p62) covalently bonded to a fragment (e.g., moiety, moiety of a fragment) of a compound described herein. [0497] In some embodiments, the compound fragment is covalently (e.g., irreversibly) bonded to an amino acid corresponding to C26 of human p62/SQSTM1 protein. In some embodiments, the compound fragment is covalently (e.g., irreversibly) bonded to an amino acid corresponding to C27 of human p62/SQSTM1protein. In some embodiments, the compound fragment is covalently (e.g., irreversibly) bonded to an amino acid corresponding to C113 of human p62/SQSTM1protein. [0498] In some embodiments, the autophagy adapter protein covalently bonded to a autophagy adapter protein binder or compound described herein is the product of a reaction between the autophagy adapter protein and a autophagy adapter protein binder or compound described herein. It will be understood that the covalently bonded autophagy adapter protein and autophagy adapter protein binder (e.g., compound described herein) are the remnants of the reactant autophagy adapter protein and autophagy adapter protein binder or compound, wherein each reactant now participates in the covalent bond between the autophagy adapter protein and autophagy adapter protein binder or compound. In some embodiments, of the covalently bonded autophagy adapter protein and compound described herein, the remnant of the E substituent is a linker including a covalent bond between the autophagy adapter protein and the remainder of the compound described herein. It will be understood by a person of ordinary skill in the art that when a autophagy adapter protein is covalently bonded to a autophagy adapter protein binder (e.g., compound described herein), the autophagy adapter protein binder (e.g., compound described herein) forms a remnant of the pre-reacted autophagy adapter protein binder (e.g., compound described herein) wherein a bond connects the remnant of the autophagy adapter protein binder (e.g., compound described herein) to the remnant of the autophagy adapter protein (e.g., cysteine sulfur, sulfur of amino acid corresponding to C26 of human p62/SQSTM1 protein, sulfur of amino acid corresponding to C27 of human p62/SQSTM1protein, sulfur of C26 of human p62/SQSTM1 protein, sulfur of C27 of human p62/SQSTM1protein, sulfur of C113 of human p62/SQSTM1protein). The remnant of the autophagy adapter protein binder (e.g., a compound described herein) may also be called a portion of the autophagy adapter protein binder. III. Pharmaceutical compositions [0499] In a further aspect, provided herein is a pharmaceutical composition including a compound described herein (e.g., a targeted autophagy degrader) and a pharmaceutically acceptable excipient. [0500] In some embodiments, the pharmaceutical composition includes an effective amount of the compound. In some embodiments, the pharmaceutical composition includes a therapeutically effective amount of the compound. In some embodiments, the pharmaceutical composition includes a second agent. In some embodiments, of the pharmaceutical compositions, the pharmaceutical composition includes a second agent in a therapeutically effective amount. [0501] The pharmaceutical compositions may include optical isomers, diastereomers, or pharmaceutically acceptable salts of the modulators disclosed herein. The compound included in the pharmaceutical composition may be covalently attached to a carrier moiety. Alternatively, the compound included in the pharmaceutical composition is not covalently linked to a carrier moiety. [0502] In another aspect, provided herein is a pharmaceutical composition including a targeted autophagy degrader (e.g., as described herein or a compound described herein) and a pharmaceutically acceptable excipient. [0503] In some embodiments, the pharmaceutical composition includes an effective amount of the targeted autophagy degrader. In some embodiments, the pharmaceutical composition includes a therapeutically effective amount of the targeted autophagy degrader. In some embodiments, the pharmaceutical composition includes a second agent. In some embodiments, of the pharmaceutical compositions, the pharmaceutical composition includes a second agent in a therapeutically effective amount. In some embodiments, the second agent is an agent for treating cancer. In some embodiments, the second agent is an agent for treating a neurodegenerative disease (e.g., Huntington’s Disease, Alzheimer Disease, or Parkinson’s Disease). In some embodiments, the second agent is an agent for treating a disease associated with a protein aggregate. In some embodiments, the second agent is an agent for treating a metabolic disease. In some embodiments, the second agent is an agent for treating an autoimmune disease. In some embodiments, the second agent is an agent for treating an infectious disease. In some embodiments, the second agent is an agent for treating an inflammatory disease. In some embodiments, the second agent is an agent for treating Huntington’s disease. IV. Methods for treating diseases [0504] In a further aspect, provided herein is a method for treating a disease associated with a cellular component (e.g., aberrant level of a cellular component), the method including contacting the cellular component with a targeted autophagy degrader (e.g., as described herein). A targeted autophagy degrader includes any compound described herein wherein the monovalent targeted autophay protein binder is a monovalent form of formula (A), (B), (C), (I), (I-a), (II), (II-a), (II-b), (III), (III-a), (III-b), (III-c), (III-d), (III-e), (III-f), (III-g), (III-h), (III-i), (III-j), (IV), (IV-a), (IV-b), (IV-c), (IV-d), (IV-e), (IV-f), (IV-g), (IV-h), (IV-i), (V), (V-a), (V-b), (V-c), (V-d), (V-e), (V-f), (V-g), (V-h), (VI), (VI-a), (VI-b), (VI-c), (VI-d), (VI- g), (VI-h), (VII), or (VII-a), or any variation or embodiment thereof. In another aspect, provided herein is a method for treating a disease associated with a cellular component (e.g., aberrant level of a cellular component), the method including administering to a subject in need thereof a therapeutically effective amount of a compound described herein. [0505] In another aspect, provided herein is a method for treating cancer, the method including contacting a cellular component associated with cancer with a targeted autophagy degrader (e.g., as described herein). [0506] In another aspect, provided herein is a method for treating cancer, the method including administering to a subject in need thereof a therapeutically effective amount of a compound described herein. In another aspect, provided herein is a method for treating cancer, the method including administering to a subject in need thereof a therapeutically effective amount of a targeted autophagy degrader (e.g., as described herein). [0507] In another aspect, provided herein is a method for treating neurodegenerative disease, the method including contacting a cellular component associated with the neurodegenerative disease with a targeted autophagy degrader (e.g., as described herein). [0508] In another aspect, provided herein is a method for treating a neurodegenerative disease, the method including administering to a subject in need thereof a therapeutically effective amount of a compound described herein. In another aspect, provided herein is a method for treating a neurodegenerative disease, the method including administering to a subject in need thereof a therapeutically effective amount of a targeted autophagy degrader (e.g., as described herein). In some embodiments, the neurodegenerative disease is Huntington Disease, Alzheimer Disease, or Parkinson’s Disease. [0509] In another aspect, provided herein is a method for treating a metabolic disease, the method including contacting a cellular component associated with the metabolic disease with a targeted autophagy degrader (e.g., as described herein). [0510] In another aspect, provided herein is a method for treating a metabolic disease, the method including administering to a subject in need thereof a therapeutically effective amount of a compound described herein. In another aspect, provided herein is a method for treating a metabolic disease, the method including administering to a subject in need thereof a therapeutically effective amount of a targeted autophagy degrader (e.g., as described herein). [0511] In another aspect, provided herein is a method for treating an infectious disease, the method including contacting a cellular component associated with the infectious disease with a targeted autophagy degrader (e.g., as described herein). [0512] In another aspect, provided herein is a method for treating an infectious disease, the method including administering to a subject in need thereof a therapeutically effective amount of a compound described herein. In another aspect, provided herein is a method for treating an infectious disease, the method including administering to a subject in need thereof a therapeutically effective amount of a targeted autophagy degrader (e.g., as described herein). [0513] In another aspect, provided herein is a method for treating an autoimmune disease, the method including contacting a cellular component associated with the autoimmune disease with a targeted autophagy degrader (e.g., as described herein). [0514] In another aspect, provided herein is a method for treating an autoimmune disease, the method including administering to a subject in need thereof a therapeutically effective amount of a compound described herein. In another aspect, provided herein is a method for treating an autoimmune disease, the method including administering to a subject in need thereof a therapeutically effective amount of a targeted autophagy degrader (e.g., as described herein). [0515] In another aspect, provided herein is a method for treating an inflammatory disease, the method including contacting a cellular component associated with the inflammatory disease with a targeted autophagy degrader (e.g., as described herein). [0516] In another aspect, provided herein is a method for treating an inflammatory disease, the method including administering to a subject in need thereof a therapeutically effective amount of a compound described herein. In another aspect, provided herein is a method for treating an inflammatory disease, the method including administering to a subject in need thereof a therapeutically effective amount of a targeted autophagy degrader (e.g., as described herein). [0517] In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a protein (e.g., BRD4, KRAS, MYC, YAP, TAZ, CTNNB1, APP, HTT, SNCA, NRF2, or MAPT). [0518] In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a protein aggregate (e.g., HTT, APP, SNCA, or MAPT). [0519] In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a protein associated with an organelle (e.g., PINK1, ATG32, ESYT, PI3KC3, RAB10, or ATGL). In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a protein associated with the mitochondria (e.g., ATG32). In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a protein associated with the endoplasmic reticuluum (e.g., ESYT or PI3KC3). In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of an organelle. In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a mitochondria. In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of an endoplasmic reticuluum. [0520] The compounds described herein can be administered alone or can be co- administered to the patient. Co-administration is meant to include simultaneous or sequential administration of the compounds individually or in combination (more than one compound). Thus, the preparations can also be combined, when desired, with other active substances (e.g., to reduce metabolic degradation or anti-cancer agents). [0521] In another aspect, provided herein is a method for treating a disease associated with a protein aggregate, the method including administering to a subject in need thereof a therapeutically effective amount of a compound described herein. In another aspect, provided herein is a method for treating a disease associated with a protein aggregate, the method including administering to a subject in need thereof a therapeutically effective amount of a targeted autophagy degrader (e.g., as described herein). In some embodiments, the disease associated with a protein aggregate is a neurodegenerative disease (e.g., Huntington’s Disease, Alzheimer Disease, or Parkinson’s Disease). In some embodiments, the disease associated with a protein aggregate is Alzheimer’s disease and the protein aggregate is an aggregate including beta amyloid. In some embodiments, the disease associated with a protein aggregate is diabetes mellitus type 2 and the protein aggregate is an aggregate including IAPP. In some embodiments, the disease associated with a protein aggregate is Parkinson’s disease and the protein aggregate is an aggregate including alpha- synuclein. In some embodiments, the disease associated with a protein aggregate is transmissible spongiform encephalopathy and the protein aggregate is an aggregate including PrP (e.g., PrP(Sc)). In some embodiments, the disease associated with a protein aggregate is fatal familial insomnia and the protein aggregate is an aggregate including PrP (e.g., PrP(Sc)). In some embodiments, the disease associated with a protein aggregate is Huntington’s disease and the protein aggregate is an aggregate including Huntingtin. In some embodiments, the disease associated with a protein aggregate is medullary carcinoma of the thyroid and the protein aggregate is an aggregate including calcitonin. In some embodiments, the disease associated with a protein aggregate is cardiac arrhythmia (e.g., isolated atrial amyloidosis) and the protein aggregate is an aggregate including atrial natriuretic factor. In some embodiments, the disease associated with a protein aggregate is atherosclerosis and the protein aggregate is an aggregate including apolipoprotein A1. In some embodiments, the disease associated with a protein aggregate is rheumatoid arthritis and the protein aggregate is an aggregate including serum amyloid A. In some embodiments, the disease associated with a protein aggregate is aortic medial amyloid and the protein aggregate is an aggregate including medin. In some embodiments, the disease associated with a protein aggregate is prolactinomas and the protein aggregate is an aggregate including prolactin. In some embodiments, the disease associated with a protein aggregate is familial amyloid polyneuropathy and the protein aggregate is an aggregate including transthyretin. In some embodiments, the disease associated with a protein aggregate is hereditary non-neuropathic systemic amyloidosis and the protein aggregate is an aggregate including lysozyme. In some embodiments, the disease associated with a protein aggregate is dialysis related amyloidosis and the protein aggregate is an aggregate including beta-2 microglobulin. In some embodiments, the disease associated with a protein aggregate is Finnish amyloidosis and the protein aggregate is an aggregate including gelsolin. In some embodiments, the disease associated with a protein aggregate is lattice corneal dystrophy and the protein aggregate is an aggregate including keratoepithelin. In some embodiments, the disease associated with a protein aggregate is cerebral amyloid angiopathy and the protein aggregate is an aggregate including beta amyloid. In some embodiments, the disease associated with a protein aggregate is cerebral amyloid angiopathy (Icelandic type) and the protein aggregate is an aggregate including cystatin. In some embodiments, the disease associated with a protein aggregate is systemic AL amyloidosis and the protein aggregate is an aggregate including immunoglobulin light chain AL. In some embodiments, the disease associated with a protein aggregate is sporadic inclusion body myositis and the protein aggregate is an aggregate including S-IBM. In some embodiments, the disease associated with a protein aggregate is a tauopathy and the protein aggregate is an aggregate including tau protein. In some embodiments, the tauopathy is primary age-related tauopathy, CTE, progressive supranuclear palsy, corticobasal degeneration, frontotemporal demential and parkinsonism linked to chromosome 17, Lytico-Bodig disease, ganglioglioma, gangliocytoma, meningioangiomatosis, postencephalitic parkinsonism, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, pantothenate kinase-associated neurodegeneration, lipofuscinosis, or Pick’s disease. In some embodiments, the disease associated with a protein aggregate is amyloidosis. In some embodiments, the disease associated with a protein aggregate is a proteinopathy. In some embodiments, the disease associated with a protein aggregate is amyotrophic lateral sclerosis and the protein aggregate is an aggregate including superoxide dismutase, TDP043, FUS, C90RF72, and/or ubiquilin-2 (UBQLN2). In some embodiments, the disease associated with a protein aggregate is a trinucleotide repeat disorder. In some embodiments, the disease associated with a protein aggregate is a synucleinopathy. In some embodiments, the disease associated with a protein aggregate is prion disease and the protein aggregate is an aggregate including prion protein. In some embodiments, the method includes reducing the protein aggregate (e.g., reducing aggregate size, number of aggregates, or occurrence of aggregates). V. Methods of modulating activity [0522] In a further aspect, provided herein is a method of reducing the level of a cellular component, the method including contacting the cellular component with a targeted autophagy degrader (e.g., as described herein). [0523] In some embodiments, the targeted autophagy degrader (e.g., as described herein) includes a monovalent cellular component binder (e.g., as described herein) and a monovalent autophagy adapter protein binder (e.g., as described herein). In some embodiments, the monovalent cellular component binder and monovalent autophagy adapter protein binder are covalently bonded by a linker (e.g., as described herein). [0524] In some embodiments, the cellular component is a protein. In some embodiments, the cellular component is an organelle. In some embodiments, the cellular component is a complex of a plurality of optionally different proteins. In some embodiments, the cellular component is a protein aggregate. In some embodiments, the cellular component is a macromolecule. In some embodiments, the cellular component is an ion, lipid, nucleic acid, nucleotide, amino acid, protein, particle, organelle, cellular compartment, microorganism, vesicle, or small molecule. [0525] In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a protein associated with an organelle (e.g., PINK1ATG32, ESYT, PI3KC3, RAB10, or ATGL). In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a protein associated with the mitochondria (e.g., ATG32). In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a protein associated with the endoplasmic reticuluum (e.g., ESYT or PI3KC3). In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of an organelle. In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of a mitochondria. In some embodiments, the method includes modulating (e.g., inhibiting relative to a control) the level or activity of an endoplasmic reticuluum. [0526] In another aspect, provided herein is a method of reducing the level of a cellular component, the method including contacting the cellular component with a targeted autophagy degrader, wherein the targeted autophagy degrader is a compound described herein. [0527] In some embodiments, the method further including the steps: A) allowing formation of an autophagosome including the cellular component-targeted autophagy degrader-autophagy adapter protein complex; B) allowing the autophagosome to acidify; and C) allowing degradation of the cellular component. VI. Process [0528] In a further aspect, provided herein is a method of reducing the level of a cellular component, the method comprising contacting a cellular component with a targeted autophagy degrader; wherein the targeted autophagy degrader comprises: i) a monovalent autophagy associated protein binder; ii) a monovalent cellular component binder; and iii) a covalent linker directly bonded to the monovalent autophagy associated protein binder and the monovalent cellular component binder. [0529] In some embodiments, the autophagy associated protein is an autophagy adapter protein. In some embodiments, the cellular component is a protein, ion, lipid, nucleic acid, nucleotide, amino acid, particle, organelle, cellular compartment, microorganism, virus, vesicle, small molecule, protein complex, protein aggregate, or macromolecule. [0530] In some embodiments, prior to the contacting, the targeted autophagy degrader is synthesized by reacting a cellular component binder, a linker, and an autophagy associated protein binder to produce the targeted autophagy degrader (e.g., a compound or composition described herein). [0531] In some embodiments, prior to the contacting, the targeted autophagy degrader is synthesized by covalently reacting a cellular component binder, a linker, and an autophagy associated protein binder to produce the targeted autophagy degrader. [0532] In some embodiments, prior to the synthesizing, the autophagy associated protein binder is identified. In some embodiments, prior to the synthesizing, the autophagy associated protein binder is selected and ranked according to a quantifiable property (e.g., binding ability, Lipinski’s rule, or level of inhibition). [0533] In some embodiments, the autophagy associated protein binder is identified by a method comprising the steps: i) mixing an autophagy associated protein with a library of candidate autophagy associated protein binders (e.g., in a reaction vessel); and ii) identifying the candidate autophagy associated protein binders that bind to the autophagy associated protein. In some embodiments, the candidate autophagy associated protein binders comprise a covalent cysteine modifier moiety and a candidate autophagy associated protein binder is identified as an autophagy associated protein binder by detection of covalent binding of the autophagy associated protein binder to the autophagy associated protein. In some embodiments, the detection of covalent binding of the candidate autophagy associated protein binder to the autophagy associated protein includes use of a detectable label or mass spectroscopic detection of the covalent binding. In some embodiments, prior to the synthesizing, the cellular component binder is identified. [0534] In some embodiments, the detection of covalent binding of the candidate autophagy associated protein binder to the autophagy associated protein comprises competing candidate autophagy associated protein binders against reactivity-based probes (e.g., probes described herein) in the autophagy associated protein. In some embodiments, the detection includes comparing isotopically light to heavy ratios of probe-modified autophagy associated proteins. [0535] In some embodiments, the cellular component binder is identified by a method comprising the steps: i) mixing a cellular component protein with a library of candidate cellular component binders; and ii) identifying the candidate cellular component binders that bind to the cellular component. In some embodiments, the candidate cellular component binders comprise a covalent cysteine modifier moiety and a candidate cellular component binder is identified as a cellular component binder by detection of covalent binding of the cellular component binder to the cellular component. In some embodiments, the detection of covalent binding of the candidate cellular component binder to the cellular component includes use of a detectable label or mass spectroscopic detection of the covalent binding. [0536] In some embodiments, prior to synthesizing, the autophagy associated protein binder is modified to remove a covalent cysteine modifier moiety. [0537] In some embodiments, the targeted autophagy degrader is a compound as described herein. EXAMPLES [0538] It is understood that the present disclosure has been made only by way of example, and that numerous changes in the combination and arrangement of parts can be resorted to by those skilled in the art without departing from the spirit and scope of present disclosure. Synthetic Examples [0539] The chemical reactions in the Examples described can be readily adapted to prepare a number of other compounds disclosed herein, and alternative methods for preparing the compounds of this disclosure are deemed to be within the scope of this disclosure. For example, the synthesis of non-exemplified compounds according to the present disclosure can be successfully performed by modifications apparent to those skilled in the art, e.g., by appropriately protecting interfering groups, by utilizing other suitable reagents known in the art other than those described, or by making routine modifications of reaction conditions, reagents, and starting materials. Alternatively, other reactions disclosed herein or known in the art will be recognized as having applicability for preparing other compounds of the present disclosure. [0540] Abbreviations used in the Examples include the following: ACN: acetonitrile DCM: dichloromethane DMAP: 4-Dimethylaminopyridine DMSO: dimethyl sulfoxide 1 H NMR: proton nuclear magnetic resonance HPLC: high-performance liquid chromatography TFA: trifluoroacetic acid Example S1: Synthesis of Compound 1 [0541] To a solution of N-(2,4-dimethoxybenzyl)thiazol-2-amine (70.0 mg, 279.7 umol, 1 eq.) in DCM (1.0 mL) was added pyridine (88.5 mg, 1.1 mmol, 4.0 eq.) and DMAP (3.4 mg, 28.0 umol, 0.1 eq.) followed by addition of 2-chloroacetyl chloride (47.4 mg, 419.5 umol, 1.5 eq.) at 0°C. The mixture was stirred at 25°C for 0.5 hr and then concentrated. The residue was purified by prep-HPLC (column: Phenomenex Luna C18100*30mm*5um;mobile phase: [water (0.1%TFA)-ACN]; B%: 40%-70%, 12 min) to give 2-chloro-N-(2,4- dimethoxybenzyl) -N-(thiazol-2-yl)acetamide (1) (2.1 mg, 6.1 umol, 2.2%) as a yellow solid. 1 H NMR (400MHz, DMSO-d6) d = 7.48 (d, J=3.3 Hz, 1H), 7.33 (d, J=3.7 Hz, 1H), 6.77 (br d, J=8.4 Hz, 1H), 6.57 (d, J=2.0 Hz, 1H), 6.42 (dd, J=2.2, 8.4 Hz, 1H), 5.28 (br s, 2H), 4.70 (s, 2H), 3.80 (s, 3H), 3.70 (s, 3H). ESI [M+ Na] = 349.0. Example S2: Synthesis of Compound 2 [0542] To a solution of N-benzylcyclohexanamine (90.0 mg, 475.4 umol, 1.0 eq.) and TEA (192.4 mg, 1.9 mmol, 4.0 eq.) in DCM (1.0 mL) was added 2-chloroacetyl chloride (80.6 mg, 713.2 umol, 1.5 eq.) at 0°C. The mixture was stirred at 25°C for 1 hr and then concentrated. The residue was purified by prep-HPLC (column: Nano-micro Kromasil C18 80*25mm 3um; mobile phase: [water (0.1%TFA)-ACN]; B%: 44%-64%, 7 min) to give N- benzyl-2-chloro-N-cyclohexylacetamide (2) (35.7 mg, 120.2 umol, 25.3%) as light yellow oil. 1 H NMR (400MHz, DMSO-d6) į = 7.46 - 7.12 (m, 5H), 4.67 - 4.49 (m, 3H), 4.18 (s, 1H), 3.83 - 3.45 (m, 1H), 1.76 - 1.49 (m, 5H), 1.47 - 1.15 (m, 4H), 1.10 - 0.89 (m, 1H). ESI [M+H] = 266.0. Example S3: Synthesis of Compound 3 [0543] Compound 3 was prepared following a similar procedure as described for Compound 2. [0544] N-benzyl-2-chloro-N-(cis-2-(hydroxymethyl)cyclohexyl)acetami de (3) (12.8 mg, 40.9 umol, 10.5%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Nano-micro Kromasil C1880*25mm 3um; mobile phase: [water (0.1%TFA)-ACN]; B%: 29%-59%, 7 min. 1 H NMR (400 MHz, DMSO-d6) d ppm 7.55 - 7.42 (m, 1 H), 7.41 - 7.32 (m, 1 H), 7.26 (br d, J=6.39 Hz, 1 H), 7.16 (br s, 2 H), 4.99 - 4.64 (m, 1 H), 4.58 - 4.46 (m, 1 H)ɾ4.44 - 4.18 (m, 3 H), 4.16 – 3.97 (m, 1 H), 3.90 (br d, J=13.89 Hz, 1 H), 3.64 (br t, J=9.26 Hz, 1 H), 2.25 - 2.00 (m, 1 H), 1.97 - 1.55 (m, 3 H), 1.52 - 1.17 (m, 5 H). ESI [M+ H] = 296.1. Example S4: Synthesis of Compound 4 [0545] Compound 4 was prepared following a similar procedure as described for Compound 2. [0546] N-benzyl-2-chloro-N-((1S,2S)-2-hydroxycyclopentyl)acetamide (4) (49.0 mg, 181.1 umol, 49.5%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 20%-50%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.54 - 7.19 (m, 3H), 7.17 (br d, J=7.3 Hz, 2H), 4.83 - 4.48 (m, 2H), 4.40 (d, J=13.2 Hz, 1H), 4.28 - 4.04 (m, 2H), 4.02 - 3.86 (m, 2H), 1.88 - 1.63 (m, 2H), 1.61 - 1.33 (m, 4H). ESI [M+ H] = 268.1. Example S5: Synthesis of compound 5 [0547] Compound 5 was prepared following a similar procedure as described for Compound 2. [0548] N-benzyl-2-chloro-N-((3S,4R)-4-hydroxytetrahydrofuran-3-yl)a cetamide (5) (36.5 mg, 133.4 umol, 25.8%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Gemini-NX C1875*30mm*3um; mobile phase: [water (0.1%TFA)-ACN]; B%: 20%-50%, 10 min. 1 H NMR (400MHz, DMSO-d6) d = 7.49 - 7.05 (m, 5H), 4.84 - 4.48 (m, 3H), 4.44 - 4.17 (m, 3H), 3.96 - 3.77 (m, 2H), 3.56 (br dd, J=5.3, 9.5 Hz, 2H). ESI [M+ H] = 270.0. Example S6: Synthesis of Compound 6 [0549] Compound 6 was prepared following a similar procedure as described for Compound 2. [0550] Tert-butyl 4-(2-chloro-N-cyclopropylacetamido)piperidine-1-carboxylate (6) (24.5 mg, 74.9 umol, 20.0%) was obtained as a yellow solid after prep-HPLC purification. Purification condition: column: Waters Xbridge BEH C18100*30mm*10um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 30%-60%, 10 min. 1 H NMR (400MHz, DMSO-d6) į = 4.54 (s, 2H), 4.08 - 3.81 (m, 3H), 2.68 (br s, 3H), 1.94 - 1.77 (m, 2H), 1.62 (br d, J=10.9 Hz, 2H), 1.41 (s, 9H), 0.92 - 0.78 (m, 4H). ESI [M- tBu +H] = 261.1. Example S7: Synthesis of Compound 7 [0551] Compound 7 was prepared following a similar procedure as described for Compound 2. [0552] Tert-butyl 4-(2-chloro-N-(tetrahydro-2H-pyran-4-yl)acetamido)piperidine -1- carboxylate (7) (20.0 mg, 55.4 umol, 22.5%) was obtained as a pale yellow solid after prep- HPLC purification. Purification condition: column: Waters Xbridge BEH C18 100*25mm*5um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 25%-55%, 8 min. 1 H NMR (400MHz, DMSO-d6) į = 4.41 (s, 2H), 4.05 - 3.88 (m, 3H), 3.81 (br d, J=8.6 Hz, 2H), 3.37 (br s, 1H), 3.25 (br s, 1H), 2.77 (br s, 2H), 2.38 (br d, J=10.6 Hz, 1H), 1.82 (br d, J=7.2 Hz, 1H), 1.71 - 1.56 (m, 3H), 1.41 (s, 11H), 1.36 - 1.23 (m, 2H). ESI [M- tBu +H] = 305.1. Example S8: Synthesis of Compound 8 [0553] Compound 8 was prepared following a similar procedure as described for Compound 2. [0554] Tert-butyl 4-(2-chloro-N-isopropylacetamido)azepane-1-carboxylate (8) (26.8 mg, 77.4 umol, 22.0%) was obtained as yellow oil after prep-HPLC purification. Purification condition: column: Waters Xbridge Prep OBD C18150*40mm*10um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 35%-65%, 8 min. 1 H NMR (400MHz, DMSO-d6) į = 4.27 (s, 2H), 4.04 - 3.91 (m, 1H), 3.54 (br d, J=10.5 Hz, 1H), 3.29 - 2.91 (m, 3H), 2.35 (br d, J=5.3 Hz, 1H), 1.98 - 1.61 (m, 3H), 1.50 (br s, 2H), 1.41 (s, 10H), 1.31 (br d, J=5.0 Hz, 2H), 1.14 (br d, J=4.4 Hz, 4H). ESI [M- tBu +H] =277.1. Example S9: Synthesis of Compound 9 [0555] Compound 9 was prepared following a similar procedure as described for Compound 2. [0556] Tert-butyl 4-(2-chloro-N-((5-(methoxycarbonyl)-1H-pyrrol-2-yl)methyl)ac etamido) piperidine-1-carboxylate (9) (30.0 mg, 66.7 umol, 22.5%) was obtained as a white solid after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18 100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 35%-65%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 12.07 - 11.41 (m, 1H), 6.81 - 6.64 (m, 1H), 6.20 - 5.89 (m, 1H), 4.66 - 4.32 (m, 4H), 3.96 (br s, 3H), 3.75 (br d, J=4.5 Hz, 3H), 2.86 - 2.57 (m, 2H), 1.64 - 1.43 (m, 4H), 1.42 - 1.32 (m, 9H). ESI [M- Boc +H] =314.1. Example S10: Synthesis of Compound 2 [0557] Compound 10 was prepared following a similar procedure as described for Compound 2. [0558] N-benzyl-2-chloro-N-[(3S,4R)-4-hydroxytetrahydrofuran-3-yl]a cetamide (10) (44.6 mg, 165.2 umol, 53.2%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 10%-45%, 12 min. 1 H NMR (400MHz, DMSO-d6) į = 7.39 – 7.16 (m, 5H), 4.86 - 4.45 (m, 3H), 4.40 - 4.19 (m, 3H), 3.94 - 3.73 (m, 2H), 3.62 - 3.32 (m, 3H). ESI [M +H] = 270.1. Example S11: Synthesis of Compound 11 [0559] Compound 11 was prepared following a similar procedure as described for Compound 2. [0560] N-benzyl-N-(1-benzyl-5-oxo-pyrrolidin-3-yl)-2-chloro-acetami de (11) (15.5 mg, 43.3 umol, 20.2%) was got as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 35%-55%, 12min. 1 H NMR (400MHz, DMSO-d 6 ) d = 7.40 - 7.04 (m, 10H), 4.85 (br d, J=6.4 Hz, 0.5H), 4.66 - 4.18 (m, 7H), 3.50 - 3.49 (m, 0.5H), 3.32 - 3.25 (m, 0.5H), 3.24 - 3.23 (m, 0.5H), 2.64 – 2.61 (m, 1H), 2.53 - 2.43 (m, 1H). ESI [M +H] = 357.1. Example S12: Synthesis of Compound 12 [0561] Compound 12 was prepared following a similar procedure as described for Compound 2. [0562] (S)-tert-butyl 4-(2-chloroacetyl)-3-methyl-1,4-diazepane-1-carboxylate (12) (45.0 mg, 143.9 umol, 30.8%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Waters Xbridge BEH C18100*30mm*10um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 25%-55%, 10 min. 1 H NMR (400MHz, DMSO-d 6 ) į = 4.71 - 4.09 (m, 3H), 3.95 - 3.58 (m, 3H), 3.03 - 2.69 (m, 3H), 1.70 - 1.43 (m, 2H), 1.42 - 1.26 (m, 9H), 1.14 - 0.88 (m, 3H). ESI [M- tBu +H] = 235.0. Example S13: Synthesis of Compound 13 [0563] Compound 13 was prepared following a similar procedure as described for Compound 2. [0564] 2-chloro-1-(2-methylazepan-1-yl)ethan-1-one (13) (1.1 mg, 5.9 umol, 1.5%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 30%-45%, 12 min. 1 H NMR (400MHz, DMSO-d 6 ) d = 4.48 - 4.39 (m, 1H), 4.30 - 4.17 (m, 1.5H), 3.88 - 3.74 (m, 1H), 3.52 (br d, J=16.1 Hz, 0.5H), 3.17 - 3.00 (m, 0.5H), 2.79 - 2.63 (m, 0.5H), 2.08 - 1.87 (m, 1H), 1.82 - 1.54 (m, 3H), 1.46 - 0.91 (m, 7H). ESI [M+ H] = 190.1. Example S14: Synthesis of Compound 14 [0565] Compound 14 was prepared following a similar procedure as described for Compound 2. [0566] 2-chloro-1-(4-ethyl-1,4-diazepan-1-yl)ethan-1-one (14) (22.6 mg, 61.7 umol, 3.7%) was obtained as colorless oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18150*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%-10% 10 min 1 H NMR (400MHz DMSO-d6) d = 443 (s 2H) 406 - 395 (m 1H) 3.91 - 3.65 (m, 1H), 3.63 - 3.51 (m, 4H), 3.30 - 2.93 (m, 4H), 2.24 - 1.99 (m, 2H), 1.22 (dt, J=3.2, 7.1 Hz, 3H). ESI [M+ H] = 205.1. Example S15: Synthesis of Compound 15 [0567] Compound 15 was prepared following a similar procedure as described for Compound 2. [0568] 2-chloro-1-(4-hydroxyazepan-1-yl)ethan-1-one (15) (14.1 mg, 71.4 umol, 18.1%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: (column: Waters Xbridge BEH C18100*30mm*10um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 1%-20%, 10 min. 1 H NMR (400MHz, DMSO-d 6 ) d = 4.58 (br s, 1H), 4.38 - 4.27 (m, 2H), 3.72 - 3.61 (m, 1H), 3.52 - 3.44 (m, 2H), 3.34 - 3.24 (m, 2H), 1.92 - 1.69 (m, 2H), 1.69 - 1.40 (m, 4H). ESI [M+ H] = 192.0. Example S16: Synthesis of Compound 16 [0569] Compound 16 was prepared following a similar procedure as described for Compound 2. [0570] 2-chloro-1-(4-(5-fluoropyridin-2-yl)-1,4-diazepan-1-yl)ethan one (16) (29.0 mg, 105.9 umol, 49.1% ) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Gemini-NX C1875*30mm*3um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 20%-50%, 10 min. 1 H NMR (400MHz, DMSO-d6) d = 8.04 (t, J=3.7 Hz, 1H), 7.50 - 7.41 (m, 1H), 6.72 (br s, 1H), 4.36 (s, 1H), 4.25 (s, 1H), 3.86 - 3.78 (m, 1H), 3.69 - 3.57 (m, 5H), 3.46 - 3.42 (m, 1H), 3.34 (br d, J=6.2 Hz, 1H), 1.92 - 1.72 (m, 2H). ESI [M+H] = 272.1. Example S17: Synthesis of Compound 17 [0571] Compound 17 was prepared following a similar procedure as described for Compound 2. [0572] Methyl 4-(2-chloroacetyl)-1,4-diazepane-1-carboxylate (17) (11.7 mg, 50.1 umol, 13.9%) was obtained as colorless oil after prep-HPLC purification after prep-HPLC purification. Purification condition: (column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%-30%, 12 min. 1 H NMR (400MHz, DMSO- d6) d = 4.39 - 4.30 (m, 2H), 3.60 - 3.55 (m, 3H), 3.55 - 3.47 (m, 4H), 3.43 (br d, J=4.9 Hz, 3H), 3.35 (br s, 1H), 1.80 - 1.59 (m, 2H). ESI [M+H] = 235.1. Example S18: Synthesis of Compound 18 [0573] Compound 18 was prepared following a similar procedure as described for Compound 2. [0574] Tert-butyl 4-(2-chloroacetyl)-6-hydroxy-1,4-diazepane-1-carboxylate (18) (42.1 mg, 142.0 umol, 34.1%) was obtained as a yellow solid after prep-HPLC purification. Purification condition: column: Waters Xbridge BEH C18100*30mm*10um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 15%-45%, 10 min. 1 H NMR (400MHz, DMSO-d6) d = 5.33 (br s, 1H), 4.70 - 4.13 (m, 2H), 4.09 - 3.64 (m, 4H), 3.61 - 3.44 (m, 2H), 3.30 - 3.11 (m, 1H), 3.07 - 2.69 (m, 2H), 1.38 (br s, 9H). ESI [M- tBu +H] = 237.0. Example S19: Synthesis of Compound 19 [0575] Compound 19 was prepared following a similar procedure as described for Compound 2. [0576] 2-chloro-1-(3,3-difluoroazepan-1-yl)ethanone (19) (1.3 mg, 6.5 umol, 1.6%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 20%-45%, 12 min. 1 H NMR (400MHz, DMSO-d6) į = 4.50 - 4.37 (m, 2H), 4.03 - 3.86 (m, 2H), 3.59 - 3.45 (m, 2H), 2.13 - 1.91 (m, 2H), 1.79 - 1.49 (m, 4H). ESI [M+H] = 212.1. Example S20: Synthesis of Compound 20 [0577] Compound 20 was prepared following a similar procedure as described for Compound 2. [0578] 2-chloro-1-(4-fluoroazepan-1-yl)ethanone (20) (1.4 mg, 6.7 umol, 1.1%) was obtained as colorless oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 10%-40%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.89 - 4.67 (m, 1H), 4.50 - 4.30 (m, 2H), 3.55 - 3.41 (m, 3H), 3.42 - 3.41 (m, 1H), 2.13 - 1.52 (m, 6H). ESI [M+H] = 194.1. Example S21: Synthesis of Compound 21 [0579] Compound 21 was prepared following a similar procedure as described for Compound 2. [0580] 2-chloro-1-(4-methylazepan-1-yl)ethanone (21) (1.1 mg, 5.9 umol, 1.0%) was obtained as colorless oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 35%-45%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.38 - 4.24 (m, 2H), 3.68 - 3.59 (m, 0.5H), 3.56 - 3.40 (m, 2H), 3.32 - 3.25 (m, 1H), 3.13 (ddd, J=3.2, 10.1, 13.6 Hz, 0.5H), 1.87 - 1.66 (m, 2H), 1.64 - 1.39 (m, 3H), 1.38 - 1.00 (m, 2H), 0.93 - 0.83 (m, 3H). ESI [M+H] = 190.1. Example S22: Synthesis of Compound 22 [0581] Compound 22 was prepared following a similar procedure as described for Compound 2. [0582] 2-chloro-1-(2-methyl-1,4-oxazepan-4-yl)ethanone (22) (1.3 mg, 6.5 umol, 1.0%) was obtained as colorless oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%-27%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.46 - 4.32 (m, 2H), 3.98 - 3.80 (m, 2H), 3.80 - 3.64 (m, 2H), 3.61 - 3.50 (m, 0.5H), 3.45 - 3.41 (m, 0.5H), 3.33 (br d, J=5.1 Hz, 0.5H), 3.22 (ddd, J=5.7, 7.9, 13.7 Hz, 0.5H), 3.06 (dd, J=9.8, 14.4 Hz, 0.5H), 2.88 (dd, J=9.7, 13.9 Hz, 0.5H), 1.92 - 1.70 (m, 2H), 1.11 - 1.01 (m, 3H). ESI [M+H] = 192.0. Example S23: Synthesis of Compound 23 [0583] Compound 23 was prepared following a similar procedure as described for Compound 2. [0584] 2-chloro-1-(4,4-dimethylazepan-1-yl)ethanone (23) (1.1 mg, 5.7 umol, 1.0%) was obtained as colorless oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 30%-55%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.77 (s, 2H), 3.90 - 3.81 (m, 4H), 2.12 (td, J=6.1, 11.9 Hz, 1H), 2.04 (td, J=6.1, 11.9 Hz, 1H), 1.97 - 1.92 (m, 1H), 1.84 (td, J=2.8, 5.6 Hz, 1H), 1.80 - 1.72 (m, 2H), 1.32 (d, J=7.5 Hz, 6H). ESI [M+H] = 204.0. Example S24: Synthesis of Compound 24 [0585] Compound 24 was prepared following a similar procedure as described for Compound 2. [0586] 2-chloro-1-(5-fluoro-4-hydroxy-4-(trifluoromethyl)azepan-1-y l)ethanone (24) (12.9 mg, 46.1 umol, 13.2%) was obtained as colorless oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water(0.1%TFA)-ACN]; B%: 10%-45%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 6.58 (br s, 1H), 4.99 - 4.69 (m, 1H), 4.45 - 4.31 (m, 2H), 3.83 (br dd, J=2.5, 14.4 Hz, 0.5H), 3.65 - 3.52 (m, 1H), 3.50 - 3.43 (m, 2H), 3.18 - 3.04 (m, 0.5H), 2.49 - 2.22 (m, 1H), 2.04 - 1.76 (m, 2H), 1.69 - 1.53 (m, 1H). ESI [M+H] = 278.1. Example S25: Synthesis of Compound 25 [0587] Compound 25 was prepared following a similar procedure as described for Compound 2. [0588] Ethyl 1-(2-chloroacetyl)-3-methylazepane-3-carboxylate (25) (1.1 mg, 4.4 umol, 1.1%) was obtained as colorless oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 30%-55%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.59 - 4.30 (m, 2H), 4.14 - 3.90 (m, 2H), 3.70 - 3.50 (m, 2H), 3.44 (t, J=6.0 Hz, 1H), 3.30 - 3.19 (m, 1H), 1.96 - 1.79 (m, 1H), 1.77 - 1.49 (m, 4H), 1.49 - 1.35 (m, 1H), 1.21 - 1.13 (m, 3H), 1.08 (s, 3H). ESI [M+H] = 262.1. Example S26: Synthesis of Compound 26 [0589] Compound 26 was prepared following a similar procedure as described for Compound 2. [0590] Benzyl ((1-(2-chloroacetyl)-3-methylazepan-3-yl)methyl)carbamate (26) (20.0 mg, 56.7 umol, 31.3% ) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 35%-65%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.45 - 7.23 (m, 5H), 7.07 (br t, J=6.3 Hz, 1H), 5.08 - 5.00 (m, 2H), 4.43 - 4.26 (m, 2H), 3.54 - 3.46 (m, 1H), 3.41 - 3.16 (m, 3H), 3.03 - 2.92 (m, 1H), 2.83 (dd, J=5.7, 13.7 Hz, 1H), 1.81 - 1.33 (m, 5H), 1.30 - 1.17 (m, 1H), 0.86 - 0.72 (m, 3H).季ESI [M+H] = 353.1. Example S27: Synthesis of Compound 27 [0591] Compound 27 was prepared following a similar procedure as described for Compound 2.
[0592] Benzyl ((1-(2-chloroacetyl)azepan-3-yl)methyl)carbamate (27) (24.4 mg, 71.9 umol, 22.2%) was obtained as a white solid after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 30%-55%, 12 min. 1 H NMR (400 MHz, DMSO-d6) d = 7.45 - 7.25 (m, 6H), 5.02 (d, J = 4.4 Hz, 2H), 4.39 - 4.18 (m, 2H), 3.81 - 3.49 (m, 2H), 3.35 - 3.11 (m, 1H), 3.05 - 2.81 (m, 3H), 1.86 - 1.49 (m, 5H), 1.40 - 1.01 (m, 2H). ESI [M+H] = 339.1. Example S28: Synthesis of Compound 28 [0593] Compound 28 was prepared following a similar procedure as described for Compound 2. [0594] Benzyl ((1-(2-chloroacetyl)-3-methylazepan-4-yl)methyl)carbamate (28) (9.3 mg, 26.3 umol, 11.7%) was obtained as yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 30%-55%, 12min. 1 H NMR (400MHz, DMSO-d6) d = 7.41 - 7.24 (m, 5H), 5.01 (s, 2H), 4.48 - 4.23 (m, 2H), 3.75 - 3.56 (m, 1H), 3.41 - 3.22 (m, 2H), 3.17 - 3.05 (m, 1H), 3.02 - 2.76 (m, 2H), 2.21 - 2.03 (m, 1H), 1.91 - 1.11 (m, 5H), 0.73 (dd, J=6.9, 18.3 Hz, 3H). ESI [M+H] = 353.1. Example S29: Synthesis of Compound 29 [0595] Compound 29 was prepared following a similar procedure as described for Compound 2. [0596] 2-chloro-1-(3-fluoro-3-methylazepan-1-yl)ethanone (29) (1.9 mg, 9.0 umol, 3.0%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 20%-45%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.54 (d, J=13.6 Hz, 0.5H), 4.40 (d, J=1.1 Hz, 1H), 4.20 (d, J=13.7 Hz, 0.5H), 4.05 - 3.87 (m, 1H), 3.83 - 3.71 (m, 0.5H), 3.66 - 3.41 (m, 2H), 2.94 (ddd, J=5.0, 9.0, 13.7 Hz, 0.5H), 1.87 - 1.73 (m, 6H), 1.72 - 1.45 (m, 3H). ESI [M +H] = 208.0. Example S30: Synthesis of Compound 30 [0597] Compound 30 was prepared following a similar procedure as described for Compound 2. [0598] Benzyl ((1-(2-chloroacetyl)-3-hydroxyazepan-3-yl)methyl)carbamate (30) (5.2 mg, 14.6 umol, 6.6%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 20%-50%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.46 - 7.21 (m, 5H), 5.16 - 4.96 (m, 2H), 4.60 (d, J=13.2 Hz, 1H), 4.44 - 4.23 (m, 1H), 4.02 - 3.93 (m, 1H), 3.70 - 3.50 (m, 1H), 3.32 - 3.24 (m, 1H), 3.19 - 2.93 (m, 3H), 2.82 (br t, J=8.7 Hz, 1H), 1.79 - 1.33 (m, 6H). ESI [M +H] = 355.1. Example S31: Synthesis of Compound 31 [0599] Compound 31 was prepared following a similar procedure as described for Compound 2. [0600] 2-chloro-1-(3-methylazepan-1-yl)ethanone (31) (1.2 mg, 6.5 umol, 1.2%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um;mobile phase: [water (0.1%TFA)-ACN]; B%: 25%- 50%, 12 min. 1 H NMR (400 MHz, DMSO-d6) į = 4.46 - 4.26 (m, 2H), 3.78 - 3.50 (m, 2H), 3.33 - 3.11 (m, 1H), 2.92 - 2.66 (m, 1H), 1.91 - 1.45 (m, 5H), 1.41 - 1.07 (m, 2H), 0.87 (dd, J = 6.7, 12.9 Hz, 3H). ESI [M+H] = 190.1. Example S32: Synthesis of Compound 32 [0601] Compound 32 was prepared following a similar procedure as described for Compound 2. [0602] 2-chloro-1-(3-(fluoromethyl)-3-hydroxyazepan-1-yl)ethanone (32) (14.0 mg, 61.6 umol, 22.6%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Waters Xbridge Prep OBD C18150*40mm*10um; mobile phase: [water(10mM NH 4 HCO 3 )-ACN]; B%: 1%-25%, 8 min. 1 H NMR (400MHz, CHLOROFORM-d) į = 4.45 - 4.29 (m, 1H), 4.22 - 4.03 (m, 2H), 3.98 - 3.82 (m, 1H), 3.78 - 3.44 (m, 2H), 3.42 - 3.02 (m, 2H), 2.10 - 1.48 (m, 6H). ESI [M+H] = 224.0. Example S33: Synthesis of Compound 33 [0603] Compound 33 was prepared following a similar procedure as described for Compound 2. [0604] 2-chloro-1-(4-hydroxy-4-(trifluoromethyl)azepan-1-yl)ethanon e (33) (2.6 mg, 9.8 umol, 4.3%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 5%-40%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 5.98 - 5.86 (m, 1H), 4.46 - 4.30 (m, 2H), 3.85 (br d, J=16.5 Hz, 1H), 3.65 - 3.42 (m, 2H), 3.12 - 3.03 (m, 1H), 2.11 - 1.44 (m, 6H). ESI [M+H] = 260.0. Example S34: Synthesis of Compound 34 [0605] Compound 34 was prepared following a similar procedure as described for Compound 2. [0606] Benzyl ((1-(2-chloroacetyl)-4-hydroxyazepan-4-yl)methyl)carbamate (34) (30.0 mg, 83.6 umol, 13.4%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 15%-45%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.43 - 7.27 (m, 5H), 7.18 - 7.06 (m, 1H), 5.03 (s, 2H), 4.35 (br s, 1H), 4.32 (br s, 1H), 3.77 - 3.67 (m, 1H), 3.55 - 3.26 (m, 3H), 3.16 - 2.91 (m, 2H), 2.08 - 1.80 (m, 1H), 1.69 - 1.28 (m, 5H). ESI [M+ H] = 355.1. Example S35: Synthesis of Compound 35 [0607] Compound 35 was prepared following a similar procedure as described for Compound 2. [0608] Benzyl ((1-(2-chloroacetyl)-4-methylazepan-4-yl)methyl)carbamate (35) (24.4 mg, 69.0 umol, 14.4%) was obtained as colorless oil after prep-HPLC purification. Purification condition: (column: Waters Xbridge BEH C18100*30mm*10um; mobile phase: [water (0.1%TFA)-ACN]; B%: 35%-45%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.40 - 7.27 (m, 5H), 5.03 (s, 2H), 4.40 - 4.27 (m, 2H), 3.47 - 3.22 (m, 4H), 2.97 - 2.80 (m, 2H), 1.80 - 1.60 (m, 2H), 1.57 (br dd, J=5.4, 9.0 Hz, 1H), 1.50 - 1.41 (m, 1H), 1.33 (br d, J=7.7 Hz, 2H), 0.81 (br d, J=7.2 Hz, 3H). ESI [M+ H] = 353.1. Example S36: Synthesis of Compound 36 [0609] Compound 36 was prepared following a similar procedure as described for Compound 2. [0610] 2-chloro-1-(4-fluoro-4-methylazepan-1-yl)ethanone (36) (1.1 mg, 5.3 umol, 1.8%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Waters Xbridge BEH C18100*30mm*10um; mobile phase: [water (0.1%TFA)- ACN]; B%: 15%-35%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.35 - 4.31 (m, 2H), 3.49 - 3.43 (m, 2H), 3.39 - 3.09 (m, 2H), 2.07 - 1.53 (m, 6H), 1.38 - 1.24 (m, 3H). ESI [M+H] =208.1. Example S37: Synthesis of Compound 37 [0611] Compound 37 was prepared following a similar procedure as described for Compound 2. [0612] Tert-butyl (1-(2-chloroacetyl)azepan-3-yl)carbamate (37) (11.8 mg, 40.2 umol, 9.6%) was obtained as a yellow solid after prep-HPLC purification. Purification condition: column: Waters Xbridge Prep OBD C18150*40mm*10um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 20%-50%, 8 min. 1 H NMR (400MHz, DMSO-d6) d = 7.07 - 6.66 (m, 1H), 4.61 - 4.30 (m, 2H), 3.86 - 3.39 (m, 4H), 3.22 - 2.97 (m, 1H), 1.85 - 1.50 (m, 4H), 1.39 (br d, J=7.1 Hz, 11H). ESI [M- Boc +H] =191.1. Example S38: Synthesis of Compound 38 [0613] Compound 38 was prepared following a similar procedure as described for Compound 2. [0614] Benzyl ((1-(2-chloroacetyl)-4-fluoroazepan-4-yl)methyl)carbamate (38) (11.5 mg, 31.4 umol, 11.1%) was obtained as yellow oil after prep-HPLC purification. Purification condition: column: Welch Ultimate AQ-C18150*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 25%-55%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.67 - 7.49 (m, 1H), 7.43 - 7.23 (m, 5H), 5.17 - 4.93 (m, 2H), 4.49 - 4.30 (m, 2H), 3.81 - 3.56 (m, 1H), 3.46 - 3.31 (m, 2H), 3.28 - 3.03 (m, 3H), 2.08 - 1.45 (m, 6H). ESI [M+H] =357.1. Example S39: Synthesis of Compound 39 [0615] Compound 39 was prepared following a similar procedure as described for Compound 2. [0616] 2-chloro-1-(3-hydroxy-3-methylazepan-1-yl)ethanone (39) (1.1 mg, 5.4 umol, 1.0%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Welch Ultimate AQ-C18150*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 2%-32%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.72 - 4.56 (m, 1H), 4.44 - 4.32 (m, 1H), 4.07 - 3.94 (m, 1H), 3.69 - 3.45 (m, 1H), 3.25 - 3.05 (m, 1H), 2.85 (ddd, J=5.0, 9.0, 13.6 Hz, 1H), 1.79 - 1.46 (m, 5H), 1.37 (br d, J=5.9 Hz, 1H), 1.20 - 1.04 (m, 3H). ESI [M+H] =206.1. Example S40: Synthesis of Compound 40 [0617] Compound 40 was prepared following a similar procedure as described for Compound 2. [0618] 2-chloro-1-(4,4-difluoro-5-methylazepan-1-yl)ethanone (40) (1.2 mg, 5.2 umol, 1.1%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Welch Ultimate AQ-C18150*30mm*5um; mobile phase: [water (0.1%TFA)- ACN];B%: 17%-47%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.45 - 4.35 (m, 2H), 3.67 - 3.49 (m, 3H), 3.42 - 3.35 (m, 1H), 2.40 - 2.01 (m, 3H), 1.87 - 1.73 (m, 1H), 1.62 (br d, J=1.6 Hz, 1H), 0.99 (dd, J=7.0, 9.4 Hz, 3H). ESI [M+H] =226.0. Example S41: Synthesis of Compound 41 [0619] Compound 41 was prepared following a similar procedure as described for Compound 2.
[0620] Benzyl ((1-(2-chloroacetyl)-5-methylazepan-4-yl)methyl)carbamate (41) (9.2 mg, 23.9 umol, 7.34%) was obtained as yellow oil after prep-HPLC purification. Purification condition: column: Welch Ultimate AQ-C18150*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 28%-58%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.43 - 7.24 (m, 5H), 5.01 (d, J=1.7 Hz, 2H), 4.50 - 4.26 (m, 2H), 3.56 - 3.45 (m, 2H), 3.44 - 3.26 (m, 2H), 3.01 - 2.77 (m, 2H), 2.04 - 1.85 (m, 1H), 1.80 - 1.47 (m, 4H), 1.43 - 1.24 (m, 1H), 0.82 (t, J=7.2 Hz, 3H). ESI [M+H] =353.1. Example S42: Synthesis of Compound 42 [0621] Compound 42 was prepared following a similar procedure as described for Compound 2. [0622] 1-(2-chloroacetyl)-5-methylazepan-4-one (42) (8.7 mg, 42.0 umol, 7.6%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Welch Ultimate AQ-C18150*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%-30%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.56 - 4.25 (m, 2H), 4.22 - 3.98 (m, 1H), 3.89 - 3.59 (m, 1H), 3.44 - 3.37 (m, 1H), 3.33 - 3.28 (m, 1H), 3.15 - 2.93 (m, 1H), 2.71 - 2.53 (m, 2H), 1.76 - 1.65 (m, 1H), 1.59 - 1.16 (m, 1H), 0.96 (d, J=6.6 Hz, 3H). ESI [M+H] =204.1. Example S43: Synthesis of Compound 43 [0623] Compound 43 was prepared following a similar procedure as described for Compound 2. [0624] 2-chloro-1-(4,4,5-trifluoroazepan-1-yl)ethanone (43) (1.1 mg, 4.5 umol, 1.0%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Welch Ultimate AQ-C18150*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 10%-40%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 5.16 - 4.85 (m, 1H), 4.49 - 4.33 (m, 2H), 3.62 - 3.51 (m, 3H), 3.47 - 3.40 (m, 1H), 2.43 - 1.97 (m, 4H). ESI [M+H] =230.0. Example S44: Synthesis of Compound 44 [0625] Compound 44 was prepared following a similar procedure as described for Compound 2. [0626] 2-chloro-1-(3-hydroxyazepan-1-yl)ethanone (44) (14.6 mg, 76.2 umol, 12.8%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Welch Ultimate AQ-C18150*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%-27%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.99 - 4.72 (m, 1H), 4.56 - 4.24 (m, 2H), 4.00 - 3.76 (m, 1H), 3.71 - 3.40 (m, 2H), 3.31 - 3.20 (m, 1H), 2.82 (br dd, J=9.0, 13.1 Hz, 1H), 1.86 - 1.58 (m, 4H), 1.53 - 1.17 (m, 2H). ESI [M+H] =192.1. Example S45: Synthesis of Compound 45 [0627] Compound 45 was prepared following a similar procedure as described for Compound 2. [0628] 2-chloro-1-(4-hydroxy-5-methylazepan-1-yl)ethanone (45) (41.3 mg, 200.0 umol, 66.3%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Waters Xbridge BEH C18100*30mm*10um; mobile phase: [water (0.1%TFA)- ACN]; B%: 5%-30%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.58 - 4.47 (m, 1H), 4.36 - 4.30 (m, 2H), 3.71 - 3.55 (m, 2H), 3.46 - 3.40 (m, 2H), 3.28 - 3.18 (m, 1H), 1.90 - 1.76 (m, 1H), 1.75 - 1.54 (m, 3H), 1.51 - 1.41 (m, 1H), 0.99 - 0.87 (m, 3H). ESI [M+H] =206.1. Example S46: Synthesis of Compound 46 [0629] Compound 46 was prepared following a similar procedure as described for Compound 2. [0630] Benzyl (1-(2-chloroacetyl)azepan-4-yl)carbamate (46) (83.5 mg, 256.6 umol, 48.7%) was obtained as yellow oil after prep-HPLC purification. Purification condition: column: Waters Xbridge BEH C18100*30mm*10um; mobile phase: [water (0.1%TFA)- ACN]; B%: 25%-40%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.41 - 7.27 (m, 5H), 5.01 (s, 2H), 4.44 - 4.27 (m, 2H), 3.67 - 3.57 (m, 1H), 3.49 (br dd, J=4.2, 8.6 Hz, 2H), 3.36 - 3.14 (m, 2H), 2.05 - 1.36 (m, 6H). ESI [M+H] =325.1. Example S47: Synthesis of Compound 47 [0631] Compound 47 was prepared following a similar procedure as described for Compound 2. [0632] 1-(2-chloroacetyl)-5-fluoroazepan-4-one (47) (14.1mg, 59.5 umol, 19.9%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%- 22%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 5.71 - 5.32 (m, 1H), 4.50 - 4.31 (m, 2H), 4.06 - 3.74 (m, 2H), 3.68 - 3.49 (m, 1H), 3.40 (br d, J=3.9 Hz, 1H), 2.85 - 2.68 (m, 1H), 2.66 - 2.57 (m, 1H), 2.24 - 1.71 (m, 2H). ESI [M+H] =208.1. Example S48: Synthesis of Compound 48 [0633] Compound 48 was prepared following a similar procedure as described for Compound 2. [0634] 2-chloro-1-(4-fluoro-5-hydroxyazepan-1-yl)ethanone (48) (5.7 mg, 25.9 umol, 8.8%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water(0.1%TFA)-ACN]; B%: 1%-17%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 5.20 (br dd, J=4.2, 9.9 Hz, 1H), 4.59 - 4.45 (m, 0.5H), 4.42 - 4.30 (m, 2H), 3.84 - 3.68 (m, 1H), 3.64 - 3.41 (m, 4H), 3.26 (ddd, J=2.6, 9.3, 14.1 Hz, 0.5H), 2.22 - 1.48 (m, 4H). ESI [M+H] =210.0. Example S49: Synthesis of Compound 49 [0635] Compound 49 was prepared following a similar procedure as described for Compound 2. [0636] 2-chloro-1-(4-hydroxy-4-methylazepan-1-yl)ethanone (49) (10.3 mg, 49.7 umol, 16.5%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%-30%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.39 - 4.29 (m, 2H), 3.66 - 3.42 (m, 3H), 3.30 (br s, 1H), 3.15 (ddd, J=1.9, 10.3, 13.7 Hz, 1H), 2.19 - 1.82 (m, 1H), 1.74 - 1.34 (m, 5H), 1.12 (d, J=8.4 Hz, 3H). ESI [M+H] =206.1. Example S50: Synthesis of Compound 50 [0637] Compound 50 was prepared following a similar procedure as described for Compound 2. [0638] 2-chloro-1-(6,6-difluoro-1,4-oxazepan-4-yl)ethanone (50) (5 mg, 23.3 umol, 4.2%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 10%-30%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.53 - 4.43 (m, 2H), 4.17 - 3.99 (m, 2H), 3.97 - 3.83 (m, 3H), 3.80 - 3.63 (m, 3H). ESI [M+H] =214.0. Example S51: Synthesis of Compound 51 [0639] Compound 51 was prepared following a similar procedure as described for Compound 2. [0640] 2-chloro-1-(1,4-thiazepan-4-yl)ethanone (51) (6.2 mg, 31.6 umol, 9.7%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 5%- 35%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.38 (d, J=12.5 Hz, 2H), 3.74 - 3.58 (m, 3H), 3.57 - 3.48 (m, 1H), 2.87 - 2.78 (m, 1H), 2.74 - 2.68 (m, 1H), 2.63 (td, J=6.2, 10.7 Hz, 2H), 2.01 - 1.83 (m, 2H). ESI [M+H] =194.0. Example S52: Synthesis of Compound 52 [0641] Compound 52 was prepared following a similar procedure as described for Compound 2. [0642] 2-chloro-1-(1,1-dioxido-1,4-thiazepan-4-yl)ethanone (52) (8.8 mg, 38.8 umol, 14.4%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Phenomenex Luna C18100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%-15%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 4.43 (d, J=11.2 Hz, 2H), 3.80 - 3.49 (m, 5H), 3.34 - 3.17 (m, 3H), 2.12 - 2.04 (m, 1H), 1.89 (quin, J=6.2 Hz, 1H). ESI [M+H] =226.0. Example S53: Synthesis of Compound 53 [0643] Compound 53 was prepared following a similar procedure as described for Compound 2. [0644] Ethyl 8-(2-chloroacetyl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4] diazepine-1- carboxylate (53) (15.7 mg, 39.2 umol, 19.3%) was obtained as light yellow oil after prep- HPLC purification. Purification condition: column: Phenomenex Luna C18 100*30mm*5um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%-15%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 8.38 - 8.08 (m, 1H), 5.17 - 4.98 (m, 2H), 4.41 (s, 1H), 4.36 (s, 1H), 4.32 (d, J=1.8 Hz, 1H), 4.30 (br d, J=1.8 Hz, 2H), 4.29 - 4.28 (m, 1H), 3.79 (br d, J=4.5 Hz, 2H), 2.05 - 1.75 (m, 2H), 1.32 (dt, J=5.1, 7.1 Hz, 3H). ESI [M+H] =286.1. Example S54: Synthesis of Compound 54 [0645] Compound 54 was prepared following a similar procedure as described for Compound 2. [0646] Ethyl 7-(2-chloroacetyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-d][1,4] diazepine-3- carboxylate (54) (11.0 mg, 26.2 umol, 12.9%) was obtained as light yellow oil after prep- HPLC purification. Purification condition: column: Waters Xbridge BEH C18 100*30mm*10um; mobile phase: [water (0.1%TFA)-ACN]; B%: 5%-16%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.94 (br d, J=4.5 Hz, 1H), 4.83 - 4.65 (m, 2H), 4.52 (s, 2H), 4.30 (q, J=7.1 Hz, 2H), 3.86 (br d, J=7.5 Hz, 4H), 3.33 - 3.12 (m, 2H), 1.30 (t, J=7.1 Hz, 3H). ESI [M+H] =286.0. Example S55: Synthesis of Compound 55 [0647] Compound 55 was prepared following a similar procedure as described for Compound 2. [0648] 2-chloro-1-(7-hydroxy-7,8-dihydro-4H-pyrazolo[1,5-a][1,4]dia zepin-5(6H)- yl)ethanone (55) (5.8 mg, 24.7 umol, 9.4%) was obtained as a pale yellow solid after prep- HPLC purification. Purification condition: column: Waters Xbridge BEH C18 100*30mm*10um; mobile phase: [water (0.1%TFA)-ACN]; B%: 5%-15%, 12 min. 1 H NMR (400MHz, DMSO-d6) d = 7.31 - 7.19 (m, 1H), 6.40 - 6.11 (m, 1H), 5.42 (br s, 1H), 4.87 - 4.72 (m, 1H), 4.45 - 4.25 (m, 4H), 4.17 - 3.88 (m, 1H), 3.86 - 3.57 (m, 2H), 3.46 (br d, J=7.7 Hz, 1H). ESI [M+H] =230.1. Example S56: Synthesis of Compound 56 [0649] Compound 56 was prepared following a similar procedure as described for Compound 2. [0650] 2-chloro-1-(8,9-dihydro-5H-imidazo[1,2-d][1,4]diazepin-7(6H) -yl)ethanone (56) (15.3 mg, 43.1 umol, 15.0%) was obtained as a pale yellow solid after prep-HPLC purification. Purification condition: column: Waters Xbridge BEH C18100*30mm*10um; mobile phase: [water (0.1%TFA)-ACN]; B%: 1%-8%, 12 min. 1 H NMR (400MHz, DMSO- d6) d = 7.61 (br d, J=13.8 Hz, 1H), 7.50 (br s, 1H), 4.54 (s, 2H), 4.47 - 4.40 (m, 1H), 4.38 - 4.30 (m, 1H), 3.89 - 3.84 (m, 2H), 3.79 (br s, 2H), 3.35 (br d, J=4.5 Hz, 1H), 3.23 - 3.16 (m, 1H). ESI [M+ H] = 214.1. Example S57: Synthesis of Compound 57 [0651] Compound 57 was prepared following a similar procedure as described for Compound 2. [0652] Tert-butyl 8-(2-chloroacetyl)-1,8-diazaspiro[4.6]undecane-1-carboxylate (57) (7.6 mg, 21.5 umol, 6.1%) was obtained as light yellow oil after prep-HPLC purification. Purification condition: column: Waters Xbridge BEH C18100*25mm*5um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 25%-55%, 8 min. 1 H NMR (400MHz, DMSO-d6) d = 4.45 - 4.25 (m, 2H), 3.74 - 3.44 (m, 3H), 3.26 - 2.90 (m, 3H), 2.69 - 2.51 (m, 1H), 2.41 - 2.23 (m, 2H), 1.93 (br s, 1H), 1.81 - 1.59 (m, 5H), 1.45 (br d, J=8.8 Hz, 1H), 1.35 (d, J=2.9 Hz 9H) ESI [M- Boc+H] = 2312 Example S58: Synthesis of Compound 58 [0653] Compound 58 was prepared following a similar procedure as described for Compound 2. [0654] Tert-butyl 9-(2-chloroacetyl)-2,9-diazaspiro[6.6]tridecane-2-carboxylat e (58) (20.0 mg, 54.0 umol, 17.0%) was obtained as a pale yellow solid after prep-HPLC purification. Purification condition: column: Waters Xbridge BEH C18100*25mm*5um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 35%-65%, 8 min. 1 H NMR (400MHz, DMSO-d6) d = 4.38 (s, 2H), 3.79 - 3.39 (m, 4H), 3.30 - 2.79 (m, 4H), 1.80 - 1.42 (m, 10H), 1.39 (s, 9H), 1.27 - 1.03 (m, 2H). ESI [M- Boc+ H] = 259.1. Example S59: Synthesis of Compound 59 [0655] Compound 59 was prepared following a similar procedure as described for Compound 2. [0656] Tert-butyl 11-(2-chloroacetyl)-1,8-dioxa-4,11-diazaspiro[5.6]dodecane-4 - carboxylate (59) (20.0 mg, 57.2 umol, 31.2%) was obtained as light yellow oil after prep- HPLC purification. Purification condition: column: Waters Xbridge Prep OBD C18 150*40mm*10um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 15%-45%, 8 min. 1 H NMR (400MHz, DMSO-d6) d = 4.66 - 4.32 (m, 2H), 4.02 - 3.88 (m, 1H), 3.83 - 3.42 (m, 10H), 3.31 - 3.23 (m, 1H), 3.18 - 2.93 (m, 2H), 1.41 (s, 9H). ESI [M- Boc+ H] = 249.1. Example S60: Synthesis of Compound 60 [0657] Compound 60 was prepared following a similar procedure as described for Compound 2. [0658] Tert-butyl 11-(2-chloroacetyl)-2-oxo-1,8,11-triazaspiro[5.6]dodecane-8- carboxylate (60) (4.3 mg, 11.4 umol, 3.6%) was obtained as a white solid after prep-HPLC purification. Purification condition: column: Waters Xbridge Prep OBD C18150*40mm*10um; mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 10%-40%, 8 min. 1 H NMR (400MHz, DMSO-d6) d = 7.44 - 7.04 (m, 1H), 4.53 - 4.40 (m, 1H), 4.36 - 4.25 (m, 1H), 3.87 - 3.39 (m, 7H), 3.11 (d, J=14.5 Hz, 1H), 2.20 - 2.02 (m, 2H), 1.77 - 1.50 (m, 4H), 1.45 - 1.32 (m, 9H). ESI [M+ H] = 360.1. Example S61: Synthesis of Compound 61 [0659] Compound 61 was prepared following a similar procedure as described for Compound 2. [0660] Tert-butyl 3-(2-chloroacetyl)-3,6-diazabicyclo[3.2.1]octane-6-carboxyla te (61) (21.6 mg, 74.6 umol, 17.6%) was obtained as yellow oil after prep-HPLC purification. Purification condition: column: Welch Xtimate C18150*30mm*5um;mobile phase: [water (10mM NH 4 HCO 3 )-ACN]; B%: 20%-50%, 3 min. 1 H NMR (400MHz, DMSO-d6) d = 4.48 - 4.29 (m, 1H), 4.27 - 4.06 (m, 2H), 4.03 - 3.89 (m, 1H), 3.85 - 3.63 (m, 1H), 3.29 - 3.12 (m, 2H), 3.07 - 2.79 (m, 1H), 2.67 (br dd, J=8.3, 12.8 Hz, 1H), 2.44 (br s, 1H), 1.94 - 1.67 (m, 2H), 1.44 - 1.34 (m, 9H). ESI [M- tBu+ H] = 233.0. Example S62: Synthesis of Compound 62 [0661] A mixture of tert-butyl 4-[(2-chloroacetyl)-cyclopropyl-amino]piperidine-1- carboxylate (6) (20.8 mg, 65.9 umol, 1 eq.) in TFA (0.2 mL)/DCM (0.8 mL) was stirred at 25°C for 5 min and then mixture was concentrated. The residue was diluted with deionized water (10 mL) and then lyophilized to give the product 2-chloro-N-cyclopropyl-N- (4-piperidyl)acetamide (62) (16.8 mg, 47.0 umol, 71.3%) as light yellow oil. 1 H NMR (400MHz, methanol-d4) į= 4.41 (s, 2H), 3.91 (tt, J=3.8, 12.2 Hz, 1H), 3.41 - 3.32 (m, 2H), 3.04 - 2.92 (m, 2H), 2.75 (br d, J=3.9 Hz, 1H), 2.37 (dq, J=4.0, 13.2 Hz, 2H), 1.87 (br d, J=13.6 Hz, 2H), 0.98 - 0.79 (m, 4H). ESI [M +H] = 217.1. Example S63: Synthesis of Compound 63 [0662] Compound 63 was prepared following a similar procedure as described for Compound 62. [0663] 2-chloro-N-(piperidin-4-yl)-N-(tetrahydro-2H-pyran-4-yl)acet amide (63) (12.3 mg, 32.8 umol, 78.9%) was obtained as light yellow oil. 1 H NMR (400MHz, methanol-d4) d = 4.33 (s, 2H), 4.07 - 3.88 (m, 3H), 3.58 - 3.38 (m, 5H), 3.22 - 2.84 (m, 4H), 2.27 - 1.88 (m, 2H), 1.75 (br d, J=12.3 Hz, 3H), 1.42 (brs, 1H). ESI [M +H] =261.1. Example S64: Synthesis of Compound 64 [0664] Compound 64 was prepared following a similar procedure as described for Compound 62. [0665] N-(azepan-4-yl)-2-chloro-N-isopropyl-acetamide (64) (16.8 mg, 46.5 umol, 67.2%, 84.9% purity) was obtained as colorless oil. 1 H NMR (400 MHz, methanol-d4) į= 4.24 (s, 2H), 4.17 - 4.06 (m, 1H), 3.57 - 3.41 (m, 2H), 3.30 - 3.11 (m, 3H), 2.72 - 2.56 (m, 1H), 2.55 - 2.40 (m, 1H), 2.14 – 1.97 (m, 2H), 1.92 - 1.76 (m, 2H), 1.44-1.25 (m, 6H). ESI [M +H] =233.1. Example S65: Synthesis of Compound 65 [0666] Compound 65 was prepared following a similar procedure as described for Compound 62. [0667] Methyl 5-[[(2-chloroacetyl)-(4-piperidyl)amino]methyl]-1H-pyrrole-2 -carboxylate (65) (16.3 mg, 30.8 umol, 51.1%, 81.7% purity) was obtained as light yellow oil. 1 H NMR (400MHz, methanol-d4) d = 6.83 - 6.61 (m, 1H), 6.18 - 5.91 (m, 1H), 4.58 - 4.33 (m, 3H), 4.31 - 4.19 (m, 1H), 4.07 (br d, J=12.8 Hz, 1H), 3.71 (br s, 3H), 3.46 - 3.27 (m, 2H), 3.13 - 2.82 (m, 2H), 2.19 - 1.68 (m, 4H). ESI [M +H] =314.1. Example S66: Synthesis of Compound 66 [0668] Compound 66 was prepared following a similar procedure as described for Compound 62. [0669] (S)-2-chloro-1-(2-methyl-1,4-diazepan-1-yl)ethanone (66) (41.7 mg, 117.1 umol, 85.2%) was obtained as brown oil. 1 H NMR (400 MHz, methanol-d4) d = 4.82 - 4.62 (m, 1H), 4.59 - 4.12 (m, 3H), 3.99 - 3.41 (m, 3H), 3.25 - 2.98 (m, 2H), 2.17 - 1.89 (m, 2H), 1.39 - 1.08 (m, 3H). ESI [M+ H] = 191.1. Example S67: Synthesis of Compound 67 [0670] Compound 67 was prepared following a similar procedure as described for Compound 62. [0671] 2-chloro-1-(6-hydroxy-1,4-diazepan-1-yl)ethanone (67) (17.5 mg, 50.7 umol, 87.3%) was obtained as colorless oil. 1 H NMR (400MHz, methanol-d4) d = 4.45 (d, J=13.4 Hz, 1H), 4.30 - 4.16 (m, 2H), 4.12 - 4.03 (m, 1H), 3.90 - 3.79 (m, 1H), 3.50 - 3.29 (m, 4H), 3.22 (td, J=1.7, 3.2 Hz, 1H), 3.16 - 3.07 (m, 1H). ESI [M +H] =193.1. Example S68: Synthesis of Compound 68 [0672] Compound 68 was prepared following a similar procedure as described for Compound 62. [0673] 1-(3-aminoazepan-1-yl)-2-chloro-ethanone (68) (7.3 mg, 19.9 umol, 82.7%, 82.6% purity) was obtained as colorless oil. 1 H NMR (400 MHz, methanol-d4) d = 4.33 - 4.14 (m, 2H), 3.78 - 3.58 (m, 3H), 3.45 - 3.28 (m, 2H), 2.10 - 1.94 (m, 1H), 1.91 - 1.58 (m, 3H), 1.53 - 1.37 (m, 2H). ESI [M +H] =191.1. Example S69: Synthesis of Compound 69 [0674] Compound 69 was prepared following a similar procedure as described for Compound 62. [0675] 2-chloro-1-(1,8-diazaspiro[4.6]undecan-8-yl)ethanone (69) (17.2 mg, 45.4 umol, 37.6%) was obtained as light yellow oil. 1 H NMR (400MHz, methanol-d4) d = 4.25 - 4.13 (m, 2H), 3.70 - 3.57 (m, 1H), 3.57 - 3.39 (m, 2H), 3.39 - 3.18 (m, 3H), 2.15 - 1.62 (m, 10H). ESI [M+H] = 231.1. Example S70: Synthesis of Compound 70 [0676] Compound 70 was prepared following a similar procedure as described for Compound 62. [0677] 2-chloro-1-(2,9-diazaspiro[6.6]tridecan-2-yl)ethanone (70) (13.4 mg, 32.9 umol, 71.1%) was obtained as light yellow oil. 1 H NMR (400 MHz, methanol-d4) d = 4.28 - 4.13 (m, 2H), 4.06 (br d, J = 14.5 Hz, 1H), 3.78 (td, J = 4.8, 14.2 Hz, 1H), 3.25 (br d, J = 5.1 Hz, 1H), 3.19 - 3.15 (m, 1H), 3.15 - 3.10 (m, 1H), 2.99 - 2.87 (m, 1H), 2.76 - 2.60 (m, 2H), 1.90 - 1.45 (m, 10H), 1.34 - 1.17 (m, 2H). ESI [M +H] = 259.1. Example S71: Synthesis of Compound 71 [0678] Compound 71 was prepared following a similar procedure as described for Compound 62. [0679] 2-chloro-1-(1,8-dioxa-4,11-diazaspiro[5.6]dodecan-11-yl)etha none (71) (19.4mg, 63.7 umol, 57.7%, 71.3% purity) was obtained as colorless oil. 1 H NMR (400MHz, methanol-d4) d = 4.48 (br d, J=14.3 Hz, 1H), 4.40 - 4.21 (m, 2H), 4.13 - 3.74 (m, 6H), 3.67 - 3.37 (m, 3H), 3.29 - 2.96 (m, 4H). ESI [M +H] = 249.1. Example S72: Synthesis of Compound 72 [0680] Compound 72 was prepared following a similar procedure as described for Compound 62. [0681] 8-(2-chloroacetyl)-1,8,11-triazaspiro[5.6]dodecan-2-one (72) (10 mg, 22.4 umol, 80.6%, 83.8% purity) was obtained as light yellow oil. 1 H NMR (400 MHz, methanol-d4) į = 4.52 - 4.27 (m, 2H), 4.20 - 3.75 (m, 3H), 3.74 - 3.35 (m, 4H), 3.30 - 3.16 (m, 1H), 2.50 - 2.26 (m, 2H), 2.11 - 1.64 (m, 4H). ESI [M +H] = 260.1. Example S73: Synthesis of Compound 73 [0682] Compound 73 was prepared following a similar procedure as described for Compound 62. [0683] 2-chloro-1-(3,6-diazabicyclo[3.2.1]octan-3-yl)ethanone (73) (16.5 mg, 54.5 umol, 92.6%, 71.8% purity) was obtained as colorless oil. 1 H NMR (400MHz, methanol-d4) d = 4.50 - 4.24 (m, 3H), 4.14 (br s, 1H), 4.07 - 3.83 (m, 1H), 3.57 - 3.35 (m, 2H), 3.22 (br d, J=11.8 Hz, 1H), 3.10 - 2.95 (m, 1H), 2.80 (br s, 1H), 2.19 - 2.01 (m, 2H). ESI [M +H] =189.1. Biological Examples Example B1. Inhibition Studies of the Targeted Autophagy Protein Binder. [0684] Recombinant pure human SQSTM1 protein was purchased from Origene. SQSTM1 protein (0.21 mg) was diluted into 50 mL of PBS and 1mL of either DMSO (vehicle) or covalently acting small molecule (test compound) to achieve the desired concentration. After 30 min. at 37 ºC, the samples were treated with 100 nM IA-Rhodamine (tetramethylrhodamine-5-iodoacetamide dihydroiodide; Setareh Biotech, 6222, prepared in anhydrous DMSO) for 1 hour at room temperature. Samples were then diluted with 20 mL of 4x reducing Laemmli SDS sample loading buffer (Alfa Aesar) and heated at 90 °C for 5 min. The samples were separated on precast 4-20% Criterion TGX gels (Bio-Rad Laboratories, Inc.). Fluorescent imaging was performed on a ChemiDoc MP instrument (Bio-Rad Laboratories, Inc.), and inhibition of target labeling was assessed by densitometry using ImageJ software. The initial screen was performed using 50 mM of test compound. Inhibition data for the tested compounds is provided in Table 2. Table 2. Example B2. Dose Response Studies using Compound 1 and Compound 19. [0685] Protein SQSTM1 (p62) was pre-incubated with either Compund 1 or Compound 19 at concentrations of 2, 0.5, 0.125, and 0.03 mM, followed by addition of the the reactive probe 5-carboxytetramethylrhodamine (TAMRA). Measurements were made using TAMRA fluorescence. Silver staining of the protein was used as a protein loading control. Decreasing fluorescence of TAMRA indicates binding of the test compound. The dose-response of Compound 1 and Compound 19 against SQSTM1 is shown in FIG.1. The data demonstrate that both Compound 1 and Compound 19 covalently bind to SQSTM1. [0686] It is understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and purview of this application and scope of the appended claims. All publications, patents, and patent applications cited herein are hereby incorporated by reference in their entirety for all purposes.