Title:
TARGETED STEROID CONJUGATES
Document Type and Number:
WIPO Patent Application WO/2021/142145
Kind Code:
A1
Abstract:
A compound of the formula (I): G1-L-G2, or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein G1 is a folate radical, an antifolate radical, or a folate analog radical; L is a linker; and G2 is a radical of a steroid; compositions comprising such compounds; and the use of such compounds and compositions to treat, for example, inflammation associated with a disease or disorder.
Inventors:
GARDEEN SPENCER S (US)
LOW PHILIP STEWART (US)
LOW PHILIP STEWART (US)
Application Number:
PCT/US2021/012532
Publication Date:
July 15, 2021
Filing Date:
January 07, 2021
Export Citation:
Assignee:
GARDEEN SPENCER S (US)
LOW PHILIP STEWART (US)
LOW PHILIP STEWART (US)
International Classes:
A61K31/56; A61K47/51; C07D513/00; C07D513/22; C07J7/00
Domestic Patent References:
| WO2018086139A1 | 2018-05-17 | |||
| WO2016059622A2 | 2016-04-21 |
Foreign References:
| US20140045919A1 | 2014-02-13 |
Other References:
See also references of EP 4087580A4
Attorney, Agent or Firm:
PERDOK, Monique M. et al. (US)
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