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Title:
TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO2001002407
Kind Code:
A3
Abstract:
A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14- beta -hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by an isoserine residue.

Inventors:
BOMBARDELLI EZIO (IT)
GABETTA BRUNO (IT)
PONTIROLI ALESSANDRO (IT)
Application Number:
PCT/EP2000/006185
Publication Date:
June 28, 2001
Filing Date:
July 03, 2000
Export Citation:
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Assignee:
INDENA SPA (IT)
BOMBARDELLI EZIO (IT)
GABETTA BRUNO (IT)
PONTIROLI ALESSANDRO (IT)
International Classes:
C07D493/08; A61K31/335; A61K31/337; A61K31/36; A61P35/00; C07B61/00; C07D263/06; C07D305/14; C07D493/04; C07D493/10; C07D493/00; A61K31/00; (IPC1-7): C07D493/08; A61K31/335; C07D263/06
Foreign References:
US5705508A1998-01-06
US5750562A1998-05-12
US5763628A1998-06-09
US5621121A1997-04-15
US5476954A1995-12-19
Other References:
I. OJIWA ET. AL.: "Synthesis and Structure-Activity Relationships of Taxoids Derived from 14-beta-Hydroxy-10-deacetylbaccatin III.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 2, 17 January 1997 (1997-01-17), pages 267 - 78, XP002149586
G. APPENDINO ET. AL.: "Synthesis and Evaluation of C-seco-Paclitaxel Analogues.", TETRAHEDRON LETTERS, vol. 38, no. 24, 1997, pages 4273 - 6, XP004074809
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