TERTIARY AMIDES AND METHOD OF USE

REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of the filing date of PCT Application No.

PCT/CN2016/078531, filed April 6, 2016, the entire content of which is incorporated herein by reference.

TECHNICAL FIELD

[0002] The present disclosure relates to tertiary amide compounds that are modulators of the lysophosphatidic acid receptors (LPARs), useful in treating diseases and conditions mediated and modulated by LPARs. Additionally, the present disclosure relates to compositions containing compounds of the present disclosure and processes for their preparation.

DESCRIPTION OF RELATED TECHNOLOGY

[0003] Lysophosphatidic acid (LPA) mediates a diverse array of physiological processes, including cellular proliferation, migration, adhesion and differentiation. Recently, six subtypes of LPA receptors have been revealed, and it has been demonstrated that their physiological activities occur through LPA receptors (LPARs). These processes are mediated by the interaction of LPA with one of six cognate receptors, termed LPARl-6. These LPA receptor subtypes are designated as EDG (Endothelial differentiation gene)-2, 4 and 7, respectively, and form part of the EDG receptor family as well as EDG-1, 3, 5, 6 and 8 that are sphingosine-1 -phosphate receptors. EDG-2 is also called LPAR1 (Contos, JJ.A. Mol. Pharmacol., 2000: 58(6); 1188-1196.). These LPARs are G protein coupled receptors (GPCRs) that are capable of coupling to both a multitude of G proteins, including G _i/o , G _q and G ₁₂ /i3 , and to arrestin to promote a wide array of downstream intracellular signaling cascades. The activation of these molecular pathways is dependent upon many factors, including receptor expression levels and relative abundance of each effector, cell type, and ligand. While many ligands can evoke equivalent activation of intracellular signals following receptor stimulation, some agonists preferentially signal through a single molecular pathway - a behavior termed biased signaling. Biased agonists are now well-documented for many different GPCRs, and are known to selectively activate one or more effector pathways with greater potency than the others. While biased agonists are well recognized, biased antagonists or biased modulators are a rare and relatively undocumented occurrence. We describe herein the discovery of small molecule modulators of LPAR1 that can preferentially and potently inhibit either the Gi _/0 and G _q pathways or the arrestin pathway, depending upon the compound structure. We also describe compounds that are able to potently inhibit all measured downstream signaling pathways following LPAR1 activation by LPA. [0004] LPA receptors are localized throughout the human body and distributed differently between their subtypes, and it is reflected that the role of each receptor is different dependent upon the tissues and organs where it is located. For example, there is a strong connection between LPA and carcinoma. It is known that LPA enhances the proliferation of the epithelial cells (Sturm, A. et al., Gastroenterology. 1999, 117(2):368-377), and affects proliferation of hepatocytes and stellate cells in liver diseases complicating platelet activation (Ikeda, H. et al. Biochem. Biophys. Res. Commun., 1998, 248, 436) and prostate cancer cells (Guo, C. et al, J. Urol. 2000, 163, 1027; Qi, C. et al., J. Cellular Physiol. 1998 174, 261).

[0005] LPA is also connected to the growth of various cells such as smooth muscle cells (Ediger, T.L. et al., Am. J. Physiol. Lung Cell. Mol. Physiol., 2002, 282, L91-8), fibroblasts (Roche, S. et al., Mol. Cell Biol., 1998, 18, 7119), mesangial cells (Inoue, C.N. et al., Clin. Science, 1999, 96, 431), hepatocytes, liver stellate cells (Ikeda, H. et al., Biochem. Biophys. Res. Commun., 1998, 248, 436), vascular smooth muscle cells (Tokumura, A. et al., Am. J. Physiol. Cell Physiol., 1994, 267, C204), vascular endothelial cells (Lee, H. et al., Am. J. Physiol. Cell Physiol., 2000, 278, C612), and adipocytes (Valet, P. et al., J. Clin. Invest., 1998, 101, 1431) as well as different cancer cells. LPA is also known to involve the function of chemotaxis of inflammatory cells and cell growth (Idzko, M. et al., J Immunol. 2004;172(7):4480-4485). LPA can stimulate cell proliferation and cytokine-secreting activity of immune cells (Goetzl E.J. et al., J. Imunol. 1999, 162, 2049), as well as platelet aggregation activity (Tokumura, A. et al., Biochem. Biophys. Res. Commun., 1981, 99, 391). Based on the LPAR1 knockout mouse, LPAR1 is considered to be related to kidney function.

[0006] These results indicate that inhibiting LPAR1 receptor activity is beneficial for the prevention and/or treatment of various diseases such as liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease of secretory dysfunction, and fibrosis.

[0007] Accordingly, there is a need for novel compounds able to modulate LPAR1 activity. In particular, the present disclosure provides compounds that may act as LPAR1 modulators for the treatment of fibrotic diseases. The present disclosure also provides methods for the preparation of these compounds, pharmaceutical compositions comprising these compounds and methods for the treatment of liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease of secretory dysfunction, and fibrosis by administering the compounds of the present disclosure.

SUMMARY OF THE INVENTION

[0008] The present disclosure is directed to tertiary amides having a structure of formula (I) G'-L ¹ ^ ¹ — N I -L ³ -G ³

L I ²

G ²

(I)

[0009] or a pharmaceutically acceptable salt thereof, wherein:

[0011] R is selected from the group consisting of hydrogen and fluorine;

[0012] R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

[0013] R ^Glc is selected from the group consisting of hydrogen, Ci-C ₃ alkoxy, Ci-C ₃ alkyl,

C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

[0014] wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

[0015] R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and -NHC(0)R ^x ; wherein the Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

[0016] R ^x is Q-Qalkyl; wherein the C ₁ -C ₃ alkyl is unsubstituted or optionally substituted with one, two or three fluorines;

[0017] R ^Glg is selected from the group consisting of halogen and Q-Qalkoxy; wherein the Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines; [0018] R ^Glh and R ^Gh are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

[0019] R ^Glj is selected from the group consisting of hydrogen or halogen;

[0020] R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and fluorine;

[0021] R ^Glm , R ^G1 °, R ^Glp , R ^Glq , and R ^Gls are selected from the group consisting of hydrogen and Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

[0022] one of X ¹ and X ² is O and the other is CH;

[0023] R ^Gln is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

[0024] R ^Glr is independently selected at each occurrence from the group consisting of hydrogen,

Q-Qalkoxy, Q-Qalkyl, Q-Qcycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and

Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

[0025] m is one, two or three;

[0026] n is one, two or three;

[0027] L ¹ is a bond or QR*R ² ) ;

[0028] R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

[0029] R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

[0030] G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Q-Qalkyl, wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

[0031] L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, and wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines; [0032] G ³ is selected from the group consisting of -C0 ₂ H, -P(0)(OH) ₂ , -P(0)(OH)(OCi-C ₆ alkyl), -P(0)(CH ₃ )(OH), -B(OH) ₂ , -SO ₃ H, -CH(OH)CF ₃ , -C(0)NH(OH), -C(0)NH(CN), -C(0)NHS0 ₂ R ^G3a , -S0 ₂ NHC(0)R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , -OC(0)NHS0 ₂ R ^G3a , -S0 ₂ NH ₂ , -S0 ₂ NHR ^G3a , -C(0)NHS(0)(R ^G3a )=NC(0)R ^G3a , -C(0)NHS(0)(R ^G3a )=NR ^G3b ,

[0033] R ^G3a is Q-Qalkyl, d-Qhaloalkyl, or G ^A ;

[0034] R ^G3b is hydrogen, Q-Qalkyl, d-Qhaloalkyl, or G ^A ;

[0035] G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

[0036] R ^u , at each occurrence, is independently Q-Ceaikyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

[0037] R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Q-Cehaloalkyl;

[0038] R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or Ci-Cehaloalkyl;

[0039] L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-,

-(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} -(CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{! 2} -, -(CH^ ₂ CH=CH-(CH ₂ ) _{1 2} - and -CH ₂ C(0)NH(CR ⁿ R ¹² )-;

[0040] R ³ and R ⁴ are selected from the group consisting of hydrogen,

Ci-Ceaikyl, -(Ci-C ₆ alkylenyl)-G ^B , and hydroxy, wherein at least one of R ³ and R ⁴ is other than hydrogen; or

[0041] R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

[0042] G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; [0043] R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

[0044] one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

[0045] R ⁷ and R ⁸ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

[0046] R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

[0047] one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

[0048] X ³ is O, S, or S(0)i _-2 ; and

[0049] R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Ci-Cealkyl, and -(C _! -C ₆ alkylenyl)-G ^B ; or

[0050] R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[0051] Another aspect of the present disclosure relates to pharmaceutical compositions comprising compounds of the present disclosure or pharmaceutically acceptable salts thereof, and a pharmaceutical carrier. Such compositions can be administered in accordance with a method of the present disclosure, such as part of a therapeutic regimen for treatment or prevention of conditions and disorders related to lysophosphatidic acid receptor 1 activity. In embodiments, the pharmaceutical compositions may additionally further comprise one or more therapeutically active ingredients suitable for use in combination with the compounds of the present disclosure. For example, in a more particular aspect, the additional therapeutically active ingredient is an agent for the treatment of liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease,

inflammation/immune system disease, disease of secretory dysfunction, and fibrosis.

[0052] Moreover, the compounds of the present disclosure or pharmaceutically acceptable salts thereof, useful in the pharmaceutical compositions and treatment methods disclosed herein, are pharmaceutically acceptable as prepared and used.

[0053] In embodiments, the present disclosure relates to a method of modulating the

lysophosphatidic acid receptor 1 activity. The method is useful for treating or preventing conditions and disorders related to fibrotic disease activity in mammals. More particularly, the method is useful for treating or preventing conditions and disorders related to liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, and disease by secretory dysfunction. Accordingly, the compounds and compositions of the present disclosure are useful as a medicament for treating or preventing lysophosphatidic acid receptor 1 modulated disease.

[0054] The compounds, compositions comprising the compounds or pharmaceutically acceptable salts thereof, methods for making the compounds, and methods for treating or preventing conditions and disorders by administering the compounds are further described herein.

[0055] In embodiments, the compounds of the present disclosure or pharmaceutically acceptable salts thereof are provided for use in the treatment of liver, kidney, skin, heart and lung disease, cancer- associated disease, proliferative disease, inflammation/immune system disease, disease of secretory dysfunction, and fibrosis. In embodiments, the compounds of the present disclosure or

pharmaceutically acceptable salts thereof are provided for use in the treatment of liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease of secretory dysfunction, and fibrosis by preferentially and potently inhibiting either the Gj/o and G _q pathways or the arrestin pathway.

[0056] The present disclosure also provides pharmaceutical compositions comprising a compound of the present disclosure or pharmaceutically acceptable salts thereof, and a suitable pharmaceutical carrier for use in medicine. In embodiments, the pharmaceutical composition is for use in the treatment of liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease of secretory dysfunction, and fibrosis.

[0057] These and other objects of the present disclosure are described in the following paragraphs. These objects should not be deemed to narrow the scope of the present disclosure.

BRIEF DESCRIPTION OF THE FIGURE

[0058] FIG. 1 shows a graphical representation of the effect of Example 7 in a mouse unilateral ureteral obstruction (UUO) kidney fibrosis model.

DETAILED DESCRIPTION OF THE INVENTION

[0059] Described herein are compounds of formula (I)

O

G'-L ¹ ^— N-L ³ -G ³

I

L ²

I

G ²

(I)

wherein G 1 , G2", are defined above in the Summary and below in the Detailed Description. Further, compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also described. [0060] Compounds included herein may contain one or more variable(s) that occur more than one time in any substituent or in the formulae herein. Definition of a variable on each occurrence is independent of its definition at another occurrence. Further, combinations of substituents are permissible only if such combinations result in stable compounds. Stable compounds are compounds, which can be isolated from a reaction mixture.

Definition of Terms

[0061] It is noted that, as used in this specification and the intended claims, the singular form "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to "a compound" includes a single compound as well as one or more of the same or different compounds; reference to "a pharmaceutically acceptable carrier" means a single pharmaceutically acceptable carrier as well as one or more pharmaceutically acceptable carriers, and the like.

[0062] As used in the specification and the appended claims, unless specified to the contrary, the following terms have the meaning indicated:

[0063] The term "alkenyl" as used herein, means a straight or branched hydrocarbon chain containing from 2 to 10 carbons and containing at least one carbon-carbon double bond.

Representative examples of alkenyl include, but are not limited to, ethenyl, 2-propenyl, 2-methyl-2- propenyl, 3-butenyl, 4-pentenyl, 5-hexenyl, 2-heptenyl, 2-methyl-l-heptenyl, and 3-decenyl.

[0064] The term "alkenylene" means a divalent group derived from a straight or branched chain hydrocarbon of from 2 to 10 carbon atoms containing at least one double bond. Representative examples of alkenylene include, but are not limited to, -CH=CH-, -CH=CH ₂ CH ₂ -,

and -CH=C(CH ₃ )CH ₂ -.

[0065] The term "alkoxy" as used herein, means a C C ₆ alkyl group, as defined herein, appended to the parent molecular moiety through an oxygen atom. Representative, non-limiting examples of alkoxy include methoxy, ethoxy, propoxy, 2-propoxy, butoxy, tert-butoxy, pentyloxy, and hexyloxy.

[0066] The term "alkyl" as used herein, means a straight or branched, saturated hydrocarbon chain containing from 1 to 10 carbon atoms. The term "lower alkyl" or "Ci-Cealkyl" means a straight or branched chain hydrocarbon containing from 1 to 6 carbon atoms. The term "Q-Csaikyl" means a straight or branched chain hydrocarbon containing from 1 to 3 carbon atoms. Representative examples of alkyl include, but are not limited to, methyl, ethyl, w-propyl, wo-propyl, «-butyl, sec- butyl, wo-butyl, teri-butyl, «-pentyl, isopentyl, neopentyl, «-hexyl, 3-methylhexyl, 2,2- dimethylpentyl, 2,3-dimethylpentyl, «-heptyl, «-octyl, «-nonyl, and «-decyl. [0067] The term "alkylene" or "alkylenyl" denotes a divalent group derived from a straight or branched chain hydrocarbon containing from 1 to 10 carbon atoms. Representative examples of alkylene include, but are not limited to, -CH ₂ -, -CH ₂ CH ₂ -, -CH ₂ CH ₂ CH ₂ -, -CH ₂ CH ₂ CH ₂ CH ₂ -, and -CH ₂ CH(CH ₃ )CH ₂ -.

[0068] The term "alkynyl" as used herein, means a straight or branched chain hydrocarbon group containing from 2 to 10 carbon atoms and containing at least one carbon-carbon triple bond.

Representative examples of alkynyl include, but are not limited to, acetylenyl, 1-propynyl, 2- propynyl, 3-butynyl, 2-pentynyl, and 1-butynyl.

[0069] The term "aryl" as used herein, means phenyl or a bicyclic aryl. The bicyclic aryl is naphthyl, or a phenyl fused to a monocyclic cycloalkyl, or a phenyl fused to a monocyclic cycloalkenyl. Representative examples of the aryl groups include, but are not limited to,

dihydroindenyl, indenyl, naphthyl, dihydronaphthalenyl, and tetrahydronaphthalenyl. The bicyclic aryl is attached to the parent molecular moiety through any carbon atom contained within the bicyclic ring system. The aryl groups of the present disclosure can be unsubstituted or substituted.

[0070] The term "cycloalkenyl" or "cycloalkene" as used herein, means a monocyclic or a bicyclic hydrocarbon ring system. The monocyclic cycloalkenyl has four-, five-, six-, seven- or eight carbon atoms and zero heteroatoms. The four-membered ring systems have one double bond, the five- or six-membered ring systems have one or two double bonds, and the seven- or eight-membered ring systems have one, two or three double bonds. Representative examples of monocyclic cycloalkenyl groups include, but are not limited to, cyclobutenyl, cyclopentenyl, cyclohexenyl, cycloheptenyl and cyclooctenyl. The bicyclic cycloalkenyl is a monocyclic cycloalkenyl fused to a monocyclic cycloalkyl group, or a monocyclic cycloalkenyl fused to a monocyclic cycloalkenyl group, or a bridged monocyclic ring system in which two non-adjacent carbon atoms of the monocyclic ring are linked by an alkylene bridge containing one, two, three, or four carbon atoms. Representative examples of the bicyclic cycloalkenyl groups include, but are not limited to, 4,5,6,7- tetrahydro-3aH-indene, octahydronaphthalenyl and 1,6-dihydro-pentalene. The monocyclic and bicyclic cycloalkenyl can be attached to the parent molecular moiety through any substitutable atom contained within the ring systems, and can be unsubstituted or substituted.

[0071] The term "cycloalkyl" or "cycloalkane" as used herein, means a monocyclic, a bicyclic, a tricyclic, or a spirocyclic cycloalkyl. The monocyclic cycloalkyl is a carbocyclic ring system containing three to eight carbon atoms, zero heteroatoms and zero double bonds. Examples of monocyclic ring systems include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. The bicyclic cycloalkyl is a monocyclic cycloalkyl fused to a monocyclic cycloalkyl ring, or a bridged monocyclic ring system in which two non-adjacent carbon atoms of the monocyclic ring are linked by an alkylene bridge containing one, two, three, or four carbon atoms. Representative examples of bicyclic ring systems include, but are not limited to, bicyclo[3.1.1]heptane, bicyclo[2.2.1]heptane, bicyclo[2.2.2]octane, bicyclo[3.2.2]nonane, bicyclo[3.3.1]nonane, and bicyclo[4.2.1]nonane. Tricyclic cycloalkyls are exemplified by a bicyclic cycloalkyl fused to a monocyclic cycloalkyl, or a bicyclic cycloalkyl in which two non-adjacent carbon atoms of the ring systems are linked by an alkylene bridge of 1 , 2, 3, or 4 carbon atoms. Representative examples of tricyclic-ring systems include, but are not limited to, tricyclo[3.3.1.0 ³ ' ⁷ ]nonane (octahydro-2,5- methanopentalene or noradamantane), and tricyclo[3.3.1.1 ³ ' ⁷ ]decane (adamantane). The monocyclic, bicyclic, and tricyclic cycloalkyls can be unsubstituted or substituted, and are attached to the parent molecular moiety through any substitutable atom contained within the ring system. Spirocyclic cycloalkyl is exemplified by a monocyclic or a bicyclic cycloalkyl, wherein two of the substituents on the same carbon atom of the ring, together with said carbon atom, form a 4-, 5-, or 6-membered monocyclic cycloalkyl. An example of a spirocyclic cycloalkyl is spiro[2.5]octane. The spirocyclic cycloalkyl groups of the present disclosure can be appended to the parent molecular moiety through any substitutable carbon atom of the groups.

[0072] The term "halo" or "halogen" as used herein, means CI, Br, I, or F.

[0073] The term "haloalkyl" as used herein, means an alkyl group, as defined herein, in which one, two, three, four, five, six, seven or eight hydrogen atoms are replaced by halogen.

Representative examples of haloalkyl include, but are not limited to, chloromethyl, 2-fluoroethyl, 2,2,2-trifluoroethyl, trifluoromethyl, difluoromethyl, pentafluoroethyl, 2-chloro-3-fluoropentyl, and trifluoropropyl such as 3,3,3-trifluoropropyl.

[0074] The term "heteroaryl" as used herein, means a monocyclic heteroaryl or a bicyclic heteroaryl. The monocyclic heteroaryl is a five- or six-membered ring. The five-membered ring contains two double bonds. The five-membered ring may contain one heteroatom selected from O or S; or one, two, three, or four nitrogen atoms and optionally one oxygen or sulfur atom. The six- membered ring contains three double bonds and one, two, three or four nitrogen atoms.

Representative examples of monocyclic heteroaryl include, but are not limited to, furanyl, imidazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, 1 ,3-oxazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrazolyl, pyrrolyl, tetrazolyl, thiadiazolyl, 1 ,3-thiazolyl, thienyl, triazolyl, and triazinyl. The bicyclic heteroaryl consists of a monocyclic heteroaryl fused to a phenyl, or a monocyclic heteroaryl fused to a monocyclic cycloalkyl, or a monocyclic heteroaryl fused to a monocyclic cycloalkenyl, or a monocyclic heteroaryl fused to a monocyclic heteroaryl, or a monocyclic heteroaryl fused to a monocyclic heterocycle. Representative examples of bicyclic heteroaryl groups include, but are not limited to, benzofuranyl, benzothienyl, benzoxazolyl, benzimidazolyl, benzoxadiazolyl, 6,7-dihydro- 1 ,3-benzothiazolyl, imidazo[l ,2-a]pyridinyl, indazolyl, indolyl, isoindolyl, isoquinolinyl, naphthyridinyl, pyridoimidazolyl, quinolinyl, thiazolo[5,4-Z?]pyridin-2-yl, thiazolo[5,4-(f]pyrirnidin-2- yl, and 5,6,7,8-tetrahydroquinolin-5-yl. The monocyclic and bicyclic heteroaryl groups of the present disclosure can be substituted or unsubstituted and are connected to the parent molecular moiety through any carbon atom or any nitrogen atom contained within the ring systems.

[0075] The term "heterocycle" or "heterocyclic" as used herein, means a monocyclic heterocycle, a bicyclic heterocycle, a tricyclic heterocycle, or a spirocyclic heterocycle. The monocyclic heterocycle is a three-, four-, five-, six-, seven-, or eight-membered ring containing at least one heteroatom independently selected from the group consisting of O, N, and S. The three- or four- membered ring contains zero or one double bond, and one heteroatom selected from the group consisting of O, N, and S. The five-membered ring contains zero or one double bond and one, two or three heteroatoms selected from the group consisting of O, N and S. The six-membered ring contains zero, one or two double bonds and one, two, or three heteroatoms selected from the group consisting of O, N, and S. The seven- and eight-membered rings contains zero, one, two, or three double bonds and one, two, or three heteroatoms selected from the group consisting of O, N, and S. Representative examples of monocyclic heterocycles include, but are not limited to, azetidinyl, azepanyl, aziridinyl, diazepanyl, 1 ,3-dioxanyl, 1 ,3-dioxolanyl, 1 ,3-dithiolanyl, 1 ,3-dithianyl, imidazolinyl, imidazolidinyl, isothiazolinyl, isothiazolidinyl, isoxazolinyl, isoxazolidinyl, morpholinyl, oxadiazolinyl,

oxadiazolidinyl, oxazolinyl, oxazolidinyl, oxetanyl, piperazinyl, piperidinyl, pyranyl, pyrazolinyl, pyrazolidinyl, pyrrolinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydropyridinyl, tetrahydrothienyl, thiadiazolinyl, thiadiazolidinyl, 1 ,2-thiazinanyl, 1 ,3-thiazinanyl, thiazolinyl, thiazolidinyl, thiomorpholinyl, 1, 1-dioxidothiomorpholinyl (thiomorpholine sulfone), thiopyranyl, and trithianyl. The bicyclic heterocycle is a monocyclic heterocycle fused to a phenyl group, or a monocyclic heterocycle fused to a monocyclic cycloalkyl, or a monocyclic heterocycle fused to a monocyclic cycloalkenyl, or a monocyclic heterocycle fused to a monocyclic heterocycle, or a bridged monocyclic heterocycle ring system in which two non-adjacent atoms of the ring are linked by an alkylene bridge of 1 , 2, 3, or 4 carbon atoms, or an alkenylene bridge of two, three, or four carbon atoms. Representative examples of bicyclic heterocycles include, but are not limited to, benzopyranyl, benzothiopyranyl, chromanyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzothienyl, 2,3- dihydroisoquinoline, azabicyclo[2.2.1]heptyl (including 2-azabicyclo[2.2.1]hept-2-yl), 2,3-dihydro- lH-indolyl, isoindolinyl, octahydrocyclopenta[c]pyrrolyl, octahydropyrrolopyridinyl, and tetrahydroisoquinolinyl. Tricyclic heterocycles are exemplified by a bicyclic heterocycle fused to a phenyl group, or a bicyclic heterocycle fused to a monocyclic cycloalkyl, or a bicyclic heterocycle fused to a monocyclic cycloalkenyl, or a bicyclic heterocycle fused to a monocyclic heterocycle, or a bicyclic heterocycle in which two non-adjacent atoms of the bicyclic ring are linked by an alkylene bridge of 1 , 2, 3, or 4 carbon atoms, or an alkenylene bridge of two, three, or four carbon atoms.

Examples of tricyclic heterocycles include, but not limited to, octahydro-2,5-epoxypentalene, hexahydro-2H-2,5-methanocyclopenta[Z?]furan, hexahydro-lH-1 ,4-methanocyclopenta[c]furan, aza- adamantane (l-azatricyclo[3.3.1.1 ³ ' ⁷ ]decane), oxa-adamantane (2-oxatricyclo[3.3.1.1 ³ ' ⁷ ]decane), and octahydro-lH-4,7-epiminoisoindole. The spirocyclic heterocycles are exemplified by a monocyclic heterocycle as defined herein wherein one carbon atom of the monocyclic heterocycle is bridged by two ends of an alkylene chain. In the spirocyclic heterocycle, one or more carbon atoms in the bridging alkylene chain may be replaced with a heteroatom. Examples of spirocyclic heterocycles include, but are not limited to, 4,7-diazaspiro[2.5]octane, 2-oxa-6-azaspiro[3.3]heptane, 2,6- diazaspiro[3.3]heptane, 2-oxa-5,8-diazaspiro[3.5]nonane, 2,7-diazaspiro[3.5]nonane, l,4-dioxa-8- azaspiro[4.5]decane, l,6-diazaspiro[3.3]heptane, l-azaspiro[4.4]nonane, 7-azaspiro[3.5]nonane, 1,4- dioxa-7-azaspiro[4.4]nonane, 5,8-diazaspiro[3.5]nonane, 5,8-dioxa-2-azaspiro[3.4]octane, 2-oxa-6- azaspiro[3.4]octane, 6-oxa-l-azaspiro[3.3]heptane, 6-oxa-2-azaspiro[3.4]octane, 6-oxa-2- azaspiro[3.5]nonane, and 7-oxa-2-azaspiro[3.5]nonane. The monocyclic, bicyclic, tricyclic, and spirocyclic heterocycles are connected to the parent molecular moiety through any carbon atom or any nitrogen atom contained within the rings, and can be unsubstituted or substituted.

[0076] The term "heteroatom" as used herein, means a nitrogen, oxygen, phosphorous or sulfur atom.

[0077] The term "hydroxyl" or "hydroxy" as used herein, means an -OH group.

[0078] The term "oxo" as used herein means (=0).

[0079] In some instances, the number of carbon atoms in a hydrocarbyl substituent (e.g., alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl) is indicated by the prefix "C _x -C _y ", wherein x is the minimum and y is the maximum number of carbon atoms in the substituent. Thus, for example, "Ci-Cealkyl" refers to an alkyl substituent containing from 1 to 6 carbon atoms. Illustrating further, C ₃ -C ₆ cycloalkyl means a saturated hydrocarbyl ring containing from 3 to 6 carbon ring atoms.

[0080] As used herein, the term "radiolabel" refers to a compound of the present disclosure in which at least one of the atoms is a radioactive atom or radioactive isotope, wherein the radioactive atom or isotope spontaneously emits gamma rays or energetic particles, for example alpha particles or beta particles, or positrons. Examples of such radioactive atoms include, but are not limited to, ³ H (tritium), ¹⁴ C, ⁿ C, ¹⁵ 0, ¹⁸ F, ³⁵ S, ¹²³ I, and ¹²⁵ I.

[0081] If a moiety is described as "substituted", a non-hydrogen radical is in the place of hydrogen radical of any substitutable atom of the moiety. Thus, for example, a substituted heterocycle moiety is a heterocycle moiety in which at least one non-hydrogen radical is in the place of a hydrogen radical on the heterocycle. It should be recognized that if there are more than one substitution on a moiety, each non-hydrogen radical may be identical or different (unless otherwise stated).

[0082] If a moiety is described as being "optionally substituted," the moiety may be either (1) not substituted or (2) substituted. If a moiety is described as being optionally substituted with up to a particular number of non-hydrogen radicals, that moiety may be either (1) not substituted; or (2) substituted by up to that particular number of non-hydrogen radicals or by up to the maximum number of substitutable positions on the moiety, whichever is less. Thus, for example, if a moiety is described as a heteroaryl optionally substituted with up to 3 non-hydrogen radicals, then any heteroaryl with less than 3 substitutable positions would be optionally substituted by up to only as many non-hydrogen radicals as the heteroaryl has substitutable positions. To illustrate, tetrazolyl (which has only one substitutable position) would be optionally substituted with up to one non-hydrogen radical. To illustrate further, if an amino nitrogen is described as being optionally substituted with up to 2 non- hydrogen radicals, then a primary amino nitrogen will be optionally substituted with up to 2 non- hydrogen radicals, whereas a secondary amino nitrogen will be optionally substituted with up to only 1 non-hydrogen radical.

[0083] The terms "treat", "treating", and "treatment" refer to a method of alleviating or abrogating a disease and/or its attendant symptoms.

[0084] The terms "prevent", "preventing", and "prevention" refer to a method of preventing the onset of a disease and/or its attendant symptoms or barring a subject from acquiring a disease. As used herein, "prevent", "preventing" and "prevention" also include delaying the onset of a disease and/or its attendant symptoms and reducing a subject's risk of acquiring a disease.

[0085] The phrase "therapeutically effective amount" means an amount of a compound, or a pharmaceutically acceptable salt thereof, sufficient to prevent the development of or to alleviate to some extent one or more of the symptoms of the condition or disorder being treated when

administered alone or in conjunction with another therapeutic agent or treatment in a particular subject or subject population. For example in a human or other mammal, a therapeutically effective amount can be determined experimentally in a laboratory or clinical setting, or may be the amount required by the guidelines of the United States Food and Drug Administration, or equivalent foreign agency, for the particular disease and subject being treated.

[0086] The term "subject" is defined herein to refer to animals such as mammals, including, but not limited to, primates (e.g., humans), cows, sheep, goats, pigs, horses, dogs, cats, rabbits, rats, mice and the like. In preferred embodiments, the subject is a human.

[0087] The term One or more' refers to one to four. In one embodiment it refers to one or three. In another embodiment it refers to one to three. In a further embodiment it refers to one to two. In yet other embodiment it refers to two. In yet other further embodiment it refers to one.

Compounds

[0088] Compounds of the present disclosure can have the formula (I) as described in the

Summary.

[0089] Particular values of variable groups in compounds of formula (I) are as follows. Such values can be used where appropriate with any of the other values, definitions, claims or embodiments defined hereinbefore or hereinafter. [0090] In one embodiment, G ¹ is selected from

; wherein

R is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Q-Qalkoxy, Q-Qalkyl,

C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and -NHC(0)R ^x ; wherein the Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^x is Ci-C alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two or three fluorines;

R ^Glg is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and fluorine;

R ^Glm , R ^G1 °, R ^Glp R ^Glq , and R ^Gls are independently selected at each occurrence from the group consisting of hydrogen and Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines; R ¹¹ is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines; and

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Q-Qalkyl, C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or o tionally substituted with one h droxy or one, two, or three fluorines. , wherein

R is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines; and

R ^Glc is selected from the group consisting of hydrogen, Ci-C alkoxy, Ci-C alkyl,

C -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , ^Glc , and R ^Gld is other than hydrogen.

[0092] In one embodiment, G ¹ is , wherein

R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and -NHC(0)R ^x ; wherein the Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines; and

R ^x is Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two or three fluorines.

[0093] In one embodiment, G ¹ is R ^Gl , wherein

R ^Glg is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines.

[0094] In one embodiment, G ¹ is , wherein

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and R ^Glj is selected from the group consisting of hydrogen or halogen.

[0095] In one embodiment, G ¹ is , wherein m is one, two or three.

[0096] In one embodiment, G ¹ is erein

[0097] In one embodiment, G ¹ is erein m is two.

[0098] In one embodiment, G erein m is three.

[0099] In one embodiment, G ¹ is , wherein s--' means the ring in which it is drawn is aromatic.

R ^Glm is selected from the group consisting of hydrogen and Ci-C ₃ alkyl; wherein the Ci-C ₃ alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Ci-C ₃ alkoxy; wherein the Ci-C ₃ alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines; and one of X ¹ and X ² is O and the other is CH.

[00100] In one embodiment, G ¹ is , wherein s--' means the ring in which it is drawn is aromatic.

R ^Glm is selected from the group consisting of hydrogen and Ci-C alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Ci-C alkoxy; wherein the Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines; and

X ¹ is O and X ² is CH. [00101] In one embodiment, G ¹ is , wherein s--' means the ring in which it is drawn is aromatic.

R ^Glm is selected from the group consisting of hydrogen and Ci-C ₃ alkyl; wherein the Ci-C ₃ alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Ci-C ₃ alkoxy; wherein the Ci-C ₃ alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines; and

[00102] X ¹ is CH and X ² is O. In one embodiment, G ¹ is , wherein

R ^G1 ° and R ^Glp are independently selected from the group consisting of hydrogen and Ci-C alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines.

[00103] In one embodiment, G is , wherein

[00104] R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and

fluorine. In one embodiment, G is wherein

R ^Glq is selected from the group consisting of hydrogen and Ci-C alkyl; wherein the

Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Q-Qalkyl, C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines; and n is one, two or three.

[00105] In one embodiment, G is , wherein R ^q is selected from the group consisting of hydrogen and Q-Qalkyl; wherein the

Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Q-Qalkyl, C ₃ -C ₅ cycloaikyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines; and n is one.

[00106] In one embodiment, G is , wherein

R ^Glq is selected from the group consisting of hydrogen and Ci-C alkyl; wherein the

Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Q-Qalkyl, C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines; and n is two.

In one embodiment, G , wherein

R ^Glq is selected from the group consisting of hydrogen and Ci-C alkyl; wherein the

Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Q-Qalkyl, C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines; and n is three.

[00107] In one embodiment, G ¹ is , wherein

R ^Gls is selected from the group consisting of hydrogen and Ci-C alkyl; wherein the

Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Q-Qalkyl, C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines; and n is one, two or three. [00108] In one embodiment, G ¹ is , wherein

R ^Gls is selected from the group consisting of hydrogen and Q-Qalkyl; wherein the

Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q-

C ₃ alkoxy, Q-Qalkyl, C ₃ -C ₅ cycloaikyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines; and n is one.

[00109] In one embodiment, G ¹ is , wherein

R ^Gls is selected from the group consisting of hydrogen and Q-Qalkyl; wherein the

Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Q-Qalkyl, C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines; and n is two.

[00110] In one embodiment, G ¹ is , wherein

R ^GLS is selected from the group consisting of hydrogen and Ci-C alkyl; wherein the

Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^GLR is independently selected at each occurrence from the group consisting of hydrogen, Q- C alkoxy, Ci-C alkyl, C -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines; and n is three.

[00111] In one embodiment, L ¹ is a bond or QR'R ² ); wherein

R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines.

[00112] In one embodiment, L ¹ is a bond.

[00113] In one embodiment, L ¹ is QR'R ² ); wherein

R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines.

[00114] In one embodiment, L ¹ is QR'R ² ); wherein

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Ci-C alkoxy, Ci-C alkyl and oxo; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines.

[00115] In one embodiment, G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1, 2 or 3 substituents independently selected from Q-Qalkoxy, Ci-C alkyl, or halogen, wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Ci-C alkyl, wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines.

[00116] In one embodiment, G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1, 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines.

[00117] In one embodiment, G ² is 2-furanyl or 2-thiophenyl; wherein the 2-furanyl and

2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Q-Qalkyl, wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines.

[00118] In one embodiment, L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of -CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² .

[00119] In one embodiment, L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines. [00120] In one embodiment, L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of -CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² .

[00121] In one embodiment, L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, and wherein the central carbon of -CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge ² .

[00122] In one embodiment, G ³ is selected from the group consisting of -C0 ₂ H, -P(0)(OH) ₂ , -P(0)(OH)(OC C ₆ alkyl), -P(0)(CH ₃ )(OH), -B(OH) ₂ , -S0 ₃ H, -CH(OH)CF ₃ , -C(0)NH(OH), -C(0)NH(CN), -C(0)NHS0 ₂ R ^G3a , -S0 ₂ NHC(0)R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , - OC(0)NHS0 ₂ R ^G3a , -S0 ₂ NH ₂ , -S0 ₂ NHR ^G3a , -C(0)NHS(0)(R ^G3a )=NC(0)R ^G3a , - C 0)NHS(0)(R ^G3a )=NR ^G3b ,

R ^G3a is Q-Qalkyl, d-Qhaloalkyl, or G ^A ;

R ^G3b is hydrogen, Q-Qalkyl, Q-Qhaloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Q-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Q-Cehaloalkyl; and

R ^k , at each occurrence, is independently selected from the group consisting of Q-Cealkyl or Ci-Cehaloalkyl.

[00123] In one embodiment, G ³ is -C0 ₂ H. [00124] In one embodiment, G ³ is selected from the group consisting of -P(0)(OH) ₂ , -P(0)(OH)(OC C ₆ alkyl), and -P(0)(CH ₃ )(OH).

[00125] In one embodiment, G ³ is selected from the group consisting of -C(0)NHS0 ₂ R ^G3 , -S0 ₂ NHC(0)R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , -OC(0)NHS0 ₂ R ^G3a , -S0 ₂ NH ₂ , -S0 ₂ NHR ^G3a , -C(0)NHS(0)(R ^G3a )=NC(0)R ^G3a , -C(0)NHS(0)(R ^G3a )=NR ^G3b ; wherein

R ^G3a is Ci-Qalkyl, d-dhaloalkyl, or G ^A ;

R ^G3b is hydrogen, Q-Qalkyl, d-dhaloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently d-dalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen d-dhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, d-dalkyl, or d-dhaloalkyl; and

R ^k , at each occurrence, is independently selected from the group consisting of d-dalkyl d-dhaloalkyl.

[00126] In one embodiment, G ³ is selected from the group consisting of -C(0)NHS0 ₂ R ^G3 , -C(0)NHS0 ₂ NHR ^G3a , -OC(0)NHS0 ₂ R ^G3a ; wherein

R ^G3a is d-dalkyl, d-dhaloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently d-dalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen d-dhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, d-dalkyl, or d-dhaloalkyl; and

R ^k , at each occurrence, is independently selected from the group consisting of d-dalkyl d-dhaloalkyl.

[00127] In one embodiment, G ³ is selected from the group consisting of -B(OH) ₂ , -S0 ₃ H, -CH(OH)CF ₃ , -C(0)NH(OH), and -C(0)NH(CN). [00128] In one embodiment, G ³ is selected from the group consisting

[00130] In one embodiment, L ³ is selected from the group consisting of -(CH ₂ ) ₂ -5-,

-(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} -(CH ₂ )-, -(CR ⁷ R ⁸ ) _{1 4} -(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{1 2} -, -(CH ₂ )i ₂ CH=CH-(CH ₂ ) _{! 2} - and -CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Ci-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Ci-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or Q-Qhaloalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and d-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Ci-Cealkyl, and -(Ci-C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Ci-Cealkyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00131] In one embodiment, L ³ is -(CH ₂ ) ₂ -s-.

[00132] In one embodiment, L ³ is -(CH ₂ ) ₂ -- [00133] In one embodiment, L ³ is -(CH ₂ ) ₃ -.

[00134] In one embodiment, L ³ is -(CH ₂ ) ₄ -.

[00135] In one embodiment, L ³ is -(CH ₂ ) ₅ -.

[00136] In one embodiment, L ³ is -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ are selected from the group consisting of hydrogen, Ci-Ceaikyl, -(Ci-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a Q-Cecycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Ci-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl; and

R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or Q-Qhaloalkyl.

[00137] In one embodiment, L ³ is -(CH ₂ )-(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen, and

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Ceaikyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl; and

R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or Q-Qhaloalkyl.

[00138] In one embodiment, L ³ is -(CH ₂ ) ₂ -(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Ceaikyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen, and

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Ci-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Cealkyl, or Ci-Cehaloalkyl; and

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Cealkyl or Q-Qhaloalkyl.

[00139] In one embodiment, L ³ is -(CH ₂ ) ₃ -(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Ceaikyl, -(Q-Ceaikylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen, and

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Ceaikyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl; and

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Cealkyl or Ci-Cehaloalkyl.

[00140] In one embodiment, L ³ is -(CH ₂ ) ₄ -(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ are selected from the group consisting of hydrogen, Ci-Ceaikyl, -(Ci-Ceaikylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen, and

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Ci-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl; and

R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or

Q-Qhaloalkyl.

[00141] In one embodiment, L ³ is -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene.

[00142] In one embodiment, L ³ is -(CH ₂ )-(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene.

[00143] In one embodiment, L ³ is -(CH ₂ ) ₂ -(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene.

[00144] In one embodiment, L ³ is -(CH ₂ ) ₃ -(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene.

[00145] In one embodiment, L ³ is -(CH ₂ ) ₄ -(CR ³ R ⁴ )-, wherein

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene.

[00146] In one embodiment, L ³ is -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} -(CH ₂ )-, wherein

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; and

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl.

[00147] In one embodiment, L ³ is -(CH ₂ )-(CR ⁵ R ⁶ )-(CH ₂ )-, wherein

R ⁵ is independently selected from the group consisting of hydrogen and Ci-Cealkyl; and

R ⁶ is hydroxy.

[00148] In one embodiment, L ³ is -(CH ₂ )-(CR ⁵ R ⁶ ) ₂ -(CH ₂ )-, wherein

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; and

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl.

[00149] In one embodiment, L ³ is -(CH ₂ )-(CR ⁵ R ⁶ ) ₃ -(CH ₂ )-, wherein

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; and

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl.

[00150] In one embodiment, L ³ and G ³ together are , wherein R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; and

one R ⁶ is selected from the group consisting of hydrogen and Q-Cealkyl.

[00151] In one embodiment, L ³ is -(CR ⁷ R ⁸ )i_ ₄ -(CH ₂ )-, wherein

R ⁷ and R ⁸ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl.

[00152] In one embodiment, L ³ is -(CR ⁷ R ⁸ )-(CH ₂ )-, wherein

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl.

[00153] In one embodiment, L ³ is -(CR ⁷ R ⁸ ) ₂ -(CH ₂ )-, wherein

R ⁷ and R ⁸ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl.

[00154] In one embodiment, L ³ is -(CR ⁷ R ⁸ ) ₃ -(CH ₂ )-, wherein

R ⁷ and R ⁸ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl.

[00155] In one embodiment, L ³ is -(CR ⁷ R ⁸ ) ₄ -(CH ₂ )-, wherein

R ⁷ and R ⁸ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl.

[00156] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{1 2} -, wherein

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; and

[00157] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ )-, wherein

R ⁹ and R ¹⁰ are independently selected from the group consisting of hydrogen and Ci-Cealkyl; and

X ³ is O.

[00158] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ )-, wherein

R ⁹ and R ¹⁰ are independently selected from the group consisting of hydrogen and Ci-Cealkyl; and

X ³ is S.

[00159] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ )-, wherein

R ⁹ and R ¹⁰ are independently selected from the group consisting of hydrogen and Q-Cealkyl; and

X ³ is S(0) _1-2 . [00160] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) ₂ -, wherein

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; and

X ³ is O.

[00161] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) ₂ -, wherein

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; and

X ³ is S.

[00162] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) ₂ -, wherein

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; and

[00163] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ )-, wherein

R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene; and X ³ is O.

[00164] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ )-, wherein

R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene; and X ³ is S.

[00165] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ )-, wherein

R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene; and

[00166] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) ₂ -, wherein

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene; the other R ⁹ and R ¹⁰ are independently selected from the group consisting of hydrogen and

Ci-Ceaikyl; and

X ³ is O.

[00167] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) ₂ -, wherein

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a Q-Cecycloalkylene; the other R ⁹ and R ¹⁰ are independently selected from the group consisting of hydrogen and

Ci-Ceaikyl; and

X ³ is S.

[00168] In one embodiment, L ³ is -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) ₂ -, wherein

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene; the other R ⁹ and R ¹⁰ are independently selected from the group consisting of hydrogen and

Q-Ceaikyl; and

X ³ is S(0) _1-2 . [00169] In one embodiment, L ³ is

[00170] In one embodiment, L ³ is -(CH ₂ )CH=CH-(CH ₂ )-.

[00171] In one embodiment, L ³ is -(CH ₂ )CH=CH-(CH ₂ ) ₂ -.

[00172] In one embodiment, L ³ is -(CH ₂ ) ₂ CH=CH-(CH ₂ )-.

[00173] In one embodiment, L ³ is -(CH ₂ ) ₂ CH=CH-(CH ₂ ) ₂ -.

[00174] In one embodiment, L ³ is -CH ₂ C(0)NH(CR ⁿ R ¹² )-; wherein

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Ci-Cealkyl, and -(Ci-C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring; wherein

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Ci-Cehaloalkyl; and

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Ceaikyl or Ci-Cehaloalkyl.

[00175] In one embodiment, L ³ is -CH ₂ C(0)NH(CR ⁿ R ¹² )-; wherein

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Ci-Cealkyl, and -(Ci-C ₆ alkylenyl)-G ^B ; wherein

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl; and

R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or Cj-Cghaloalkyl.

[00176] In one embodiment, L ³ is -CH ₂ C(0)NH(CR ⁿ R ¹² )-; wherein

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring. [00177] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is ; wherein

R ^Gl is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Ci-C ₃ alkoxy, Ci-C ₃ alkyl,

C ₃ -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, C ₁ -C ₃ alkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Q-Qalkyl, wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -C0 ₂ H, -P(0)(OH) ₂ , -P(0)(OH)(OQ-Qalkyl), - P(0)(CH ₃ )(OH), -B(OH) ₂ , -S0 ₃ H, -CH(OH)CF ₃ , -QO)NH(OH), -QO)NH(CN), -C(0)NHS0 ₂ R ^G3a , -S0 ₂ NHC(0)R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , -OC(0)NHS0 ₂ R ^G3a , -S0 ₂ NH ₂ , -S0 ₂ NHR ^G3a , -C(0)NHS(0)(R ^G3a )=NC(0)R ^G3a , -C(0)NHS(0)(R ^G3a )=NR ^G3b ,

R ^G3a is d-Cgalkyl, Q-Cghaioalkyl, or G ^A ;

R ^G3b is hydrogen, d-C ₆ alkyl, Ci-C ₆ haloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Ci-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or Q-Qhaloalkyl;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{1 2} -, -(CH^ ^CH^H-iC^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or one R ⁹ and R ¹⁰ and the carbon to which they are attached form a Q-Qcycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Qalkyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Qalkyl, and -(Ci-C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Qalkyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00178] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from

; wherein

R ^Gle and R ^G " are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and -NHC(0)R ^x ; wherein the Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^x is Ci-C alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two or three fluorines;

R ^Glg is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Q-Qalkyl, wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Ci-C alkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Ci-C alkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -C0 ₂ H, -P(0)(OH) ₂ , -P(0)(OH)(OCi-C ₆ alkyl), - P(0)(CH ₃ )(OH), -B(OH) ₂ , -S0 ₃ H, -CH(OH)CF ₃ , -C(0)NH(OH), -C(0)NH(CN), -C(0)NHS0 ₂ R ^G3a , -S0 ₂ NHC(0)R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , -OC(0)NHS0 ₂ R ^G3a , -S0 ₂ NH ₂ , -S0 NHR ^G3a , -C(0)NHS(0)(R ^G3a )=NC(0)R ^G3a , -C(0)NHS(0)(R ^G3a )=NR ^G3b ,

R ^G3a is Q-Qalkyl, Q-Qhaloalkyl, or G ^A ;

R ^G3b is hydrogen, Q-Qalkyl, Q-Qhaloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently

unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Q-Qalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, Q-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Qalkyl, or Q-Qhaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Qalkyl or Q-Qhaloalkyl; L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH _r X ³ -(CR ⁹ R ¹⁰ ), ₂ -, -(CH^ ^CH^H-iC^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Ci-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl,

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the Q-Cecycloalkylene is optionally fused to a phenyl ring.

[00179] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from

R and R are independently selected from the group consisting of hydrogen and fluorine; R ^m , R °, R ^p R ^q , and R ^s are independently selected at each occurrence from the group consisting of hydrogen and Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Ci-C alkyl, C -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

one of X ¹ and X ² is O and the other is CH;

m is one, two or three;

n is one, two or three;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, C ₁ -C ₃ alkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Ci-C alkyl, wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Ci-C alkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Ci-C alkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -C0 ₂ H, -P(0)(OH) ₂ , -P(0)(OH)(OCi-C ₆ alkyl), - P(0)(CH ₃ )(OH), -B(OH) ₂ , -S0 ₃ H, -CH(OH)CF ₃ , -C(0)NH(OH), -C(0)NH(CN), -C(0)NHS0 ₂ R ^G3a , -S0 ₂ NHC(0)R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , -OC(0)NHS0 ₂ R ^G3a , -S0 ₂ NH ₂ , -S0 ₂ NHR ^G3a , -C(0)NHS(0)(R ^G3a )=NC(0)R ^G3a , -C(0)NHS(0)(R ^G3a )=NR ^G3b ,

R ^G3a is d-Cgalkyl, Q-Cghaioalkyl, or G ^A ;

R ^G3b is hydrogen, d-C ₆ alkyl, Ci-C ₆ haloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Ci-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or Q-Qhaloalkyl;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{1 2} -, -(CH^ ^CH^H-iC^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl, and -(Ci-C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Ci-Cealkyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00180] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I),

R is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Ci-C alkoxy, and halogen; wherein Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Ci-C alkoxy, Ci-C alkyl,

C -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and -NHC(0)R ^x ; wherein the Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^x is Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two or three fluorines; R ⁸ is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and fluorine;

R ^Glm , R ^G1 °, R ^Glp R ^Glq , and R ^Gls are independently selected at each occurrence from the group consisting of hydrogen and Ci-C alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C alkoxy, Ci-C alkyl, C -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

one of X ¹ and X ² is O and the other is CH;

m is one, two or three;

n is one, two or three;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Ci-C alkoxy, Ci-C alkyl and oxo; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1, 2 or 3 substituents independently selected from Ci-C alkoxy, Ci-C alkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -C0 ₂ H, -P(0)(OH) ₂ , -P(0)(OH)(OQ-Qaikyi), -

P(0)(CH ₃ )(OH), -B(OH) ₂ , -S0 ₃ H, -CH(OH)CF ₃ , -QO)NH(OH), -QO)NH(CN), -C(0)NHS0 ₂ R ^G3a ,

-S0 ₂ NHC(0)R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , -OC(0)NHS0 ₂ R ^G3a , -S0 ₂ NH ₂ ,

-S0 ₂ NHR ^G3a , -C(0)NHS(0)(R ^G3a )=NC(0)R ^G3a , -C(0)NHS(0)(R ^G3a )=NR ^G3b ,

R ^G3a is Ci-Qalkyl, d-Qhaloalkyl, or G ^A ;

R ^G3b is hydrogen, Q-Qalkyl, d-Qhaloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Ci-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Ci-Cehaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Cealkyl or Ci-Cehaloalkyl;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ )i_ ₃ - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{1 2} -, -(CH^ ^CH^H-iC^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and d-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; or one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl, and -(Ci-C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Ci-Cealkyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00181] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from

R is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Q-Qalkoxy, Q-Qalkyl,

C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and -NHC(0)R ^x ; wherein the Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines; R ^x is Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two or three fluorines;

R ^Glg is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and fluorine;

R ^Glm , R ^G1 °, R ^Glp R ^Glq , and R ^Gls are independently selected at each occurrence from the group consisting of hydrogen and Ci-C alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, C ₁ -C ₃ alkyl, C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

one of X ¹ and X ² is O and the other is CH;

m is one, two or three;

n is one, two or three;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the C ₁ -C ₃ alkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Ci-C alkoxy, Ci-C alkyl and oxo; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of 2-furanyl and 2-thiophenyl; wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Ci-C alkyl, wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ; G ³ is selected from the group consisting of -C0 ₂ H, -P(0)(OH) ₂ , -P(0)(OH)(OCi-C ₆ alkyl), - P(0)(CH ₃ )(OH), -B(OH) ₂ , -SO ₃ H, -CH(OH)CF ₃ , -C(0)NH(OH), -C(0)NH(CN), -C(0)NHS0 ₂ R ^G3a , -S0 ₂ NHC(0)R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , -OC(0)NHS0 ₂ R ^G3a , -S0 ₂ NH ₂ , -S0 ₂ NHR ^G3a , -C(0)NHS(0)(R ^G3a )=NC(0)R ^G3a , -C(0)NHS(0)(R ^G3a )=NR ^G3b ,

R ^G3a is d-Cgalkyl, d-Cghaloalkyl, or G ^A ;

R ^G3b is hydrogen, d-C ₆ alkyl, Ci-C ₆ haloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Q-Ceaikyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or Q-Qhaloalkyl;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ )i_ ₃ - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{! 2} -, -(CH^ .ClfcCH-CCH,) _{! 2} - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Ci-Ceaikyl, -(Ci-Ceaikylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and d-Cgalkyl; one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Ci-Cealkyl, and -(Ci-C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Ci-Cealkyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00182] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from

R is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Ci-C alkoxy, and halogen; wherein Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Q-Qalkoxy, Q-Qalkyl,

C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines; wherein at least one of R , R ^c , and R is other than hydrogen;

R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and -NHC(0)R ^x ; wherein the Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^x is Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two or three fluorines;

R ^Glg is selected from the group consisting of halogen and Ci-C ₃ alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and fluorine;

R ^Glm , R ^G1 °, R ^Glp R ^Glq , and R ^Gls are independently selected at each occurrence from the group consisting of hydrogen and Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, C ₁ -C ₃ alkyl, C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

one of X ¹ and X ² is O and the other is CH;

m is one, two or three;

n is one, two or three;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Ci-C alkoxy, Ci-C alkyl and oxo; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, C ₁ -C ₃ alkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Q-Qalkyl, wherein the Q- alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -C0 ₂ H;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ )i_ ₃ - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{! 2} -, -(CH^ .ClfcCH-CCH,) _{! 2} - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Ci-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a Q-Cecycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Ceaikyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or Q-Qhaloalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a Q-Cecycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl, R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00183] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from

; wherein

R is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Ci-C ₃ alkoxy, and halogen; wherein Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Q-Qalkoxy, Q-Qalkyl,

C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and -NHC(0)R ^x ; wherein the Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^x is Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two or three fluorines;

R ^Glg is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines; R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and fluorine;

R ^Glm , R ^G1 °, R ^Glp R ^Glq , and R ^Gls are independently selected at each occurrence from the group consisting of hydrogen and Ci-C ₃ alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C alkoxy, Ci-C alkyl, C -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

one of X ¹ and X ² is O and the other is CH;

m is one, two or three;

n is one, two or three;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Q-Qalkyl, wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -P(0)(OH) ₂ , -P(0)(OH)(OQ-Qalkyl), and -P(0)(CH ₃ )(OH); L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH _r X ³ -(CR ⁹ R ¹⁰ ), ₂ -, -(CH^ ^CH^H-iC^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Ci-Cehaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Ceaikyl or Q-Cghaioalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and d-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Ci-Cealkyl, and -(Ci-C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Ci-Cealkyl or the Q-Cecycloalkylene is optionally fused to a phenyl ring. [00184] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from

; wherein

R is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Q-Qalkoxy, Q-Qalkyl,

C ₃ -C ₅ cycloaikyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and -NHC(0)R ^x ; wherein the Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^x is Ci-C alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two or three fluorines;

R ^Glg is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and CrQalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and fluorine; R ^m , R °, R ^p R ^q , and R ^s are independently selected at each occurrence from the group consisting of hydrogen and Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Ci-C alkyl, C -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

one of X ¹ and X ² is O and the other is CH;

m is one, two or three;

n is one, two or three;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, C ₁ -C ₃ alkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Ci-C alkyl, wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Ci-C alkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Ci-C alkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -B(OH) ₂ , -S0 ₃ H, -CH(OH)CF ₃ , -C(0)NH(OH), and -C(0)NH(CN);

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH.CH.-X^CR ⁰ ) _! 2-, -(CH ₂ ) _{1 2} CH=CH-(CH ₂ ), ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Qalkyl, -(Q-Qalkylenyl)-

G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Cealkyl, C ₂ -C ₆ aikenyl, C ₂ -C ₆ aikynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Ci-Cehaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Cealkyl or Ci-Cehaloalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl,

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Ci-Cealkyl or the Q-Cecycloalkylene is optionally fused to a phenyl ring.

[00185] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from

wherein

R is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Q-Qalkoxy, Q-Qalkyl,

Q-Qcycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and -NHC(0)R ^x ; wherein the Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^x is Ci-C alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two or three fluorines;

R ^Glg is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and fluorine;

R ^Glm , R ^G1 °, R ^Glp R ^Glq , and R ^Gls are independently selected at each occurrence from the group consisting of hydrogen and Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- Qalkoxy, Q-Qalkyl, Q-Qcycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

one of X ¹ and X ² is O and the other is CH;

m is one, two or three;

n is one, two or three;

L ¹ is a bond or QR^ ² ); R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Ci-C alkoxy, Ci-C alkyl and oxo; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Ci-C alkoxy, Ci-C alkyl, or halogen, wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Ci-C alkyl, wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with C ₁ -C ₃ alkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -C(0)NHS0 ₂ R ^G3a , -S0 ₂ NHC(0)R ^G3a ,

-C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , -OC(0)NHS0 ₂ R ^G3a , -S0 ₂ NH ₂ , -S0 ₂ NHR ^G3a ,

-C(0)NHS(0)(R ^G3a )=NC(0)R ^G3a , and -C(0)NHS(0)(R ^G3a )=NR ^G3b ; wherein,

R ^G3a is Q-Qalkyl, Q-Qhaloalkyl, or G ^A ;

R ^G3b is hydrogen, Q-Qalkyl, Q-Qhaloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently

unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Q-Qalkyl, Q-Qalkenyl, Q-Qalkynyl, halogen, Q-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Qalkyl, or Q-Qhaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Qalkyl or Q-Qhaloalkyl;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -Oi ₂ CH ₂ -X ³ -(QlVV2-, -(CH^ ^CH^H-fC^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Qalkyl, -(Q-Qalkylenyl)-

G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and d-C ₆ alkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Ci-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl, and -(C _! -C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00186] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from

selected from the group consisting of hydrogen and fluorine; R and R are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Q-Qalkoxy, Q-Qalkyl,

C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

R ^Gle and R ^Glf are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and -NHC(0)R ^x ; wherein the Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^x is Ci-C alkyl; wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two or three fluorines;

R ^Glg is selected from the group consisting of halogen and Ci-C alkoxy; wherein the

Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

R ^Glk and R ^G11 are independently selected from the group consisting of hydrogen and fluorine;

R ^Glm , R ^G1 °, R ^Glp R ^Glq , and R ^Gls are independently selected at each occurrence from the group consisting of hydrogen and Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- Qalkoxy, Q-Qalkyl, Q-Qcycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

one of X ¹ and X ² is O and the other is CH;

m is one, two or three;

n is one, two or three;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of phenyl, 2-furanyl and 2-thiophenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; and wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or Ci-C alkyl, wherein the Ci-C alkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Ci-C alkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Ci-C alkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the roup consisting of

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ )i_ ₃ - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{! 2} -, -(CH^ .Otai-CCH^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Qalkyl, -(Q-Qalkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a Q-Qcycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Qalkyl, Q-Qalkenyl, Q-Qalkynyl, halogen, Q-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Qalkyl, or Q-Qhaloalkyl; R ^k , at each occurrence, is independently selected from the group consisting of Q-Ceaikyl or

Q-Cghaioalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and d-C ₆ alkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Ci-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Ci-Cealkyl, and -(C _! -C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00187] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is selected from

R ^Gl is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Ci-C alkoxy, Ci-C alkyl,

C -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L ¹ is a bond or QR'R ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and CrQalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Cecycloalkylene or oxetane; wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1, 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Ci-C alkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Ci-C alkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is -C0 ₂ H;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ )i_ ₃ - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{! 2} -, -(CH^ .ClfcCH-CCH,) _{! 2} - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Ci-Ceaikyl, -(Ci-Ceaikylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Ceaikyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Ceaikyl, or Q-Cehaloaikyl;

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Ceaikyl or Ci-Cehaloalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl, and -(C _! -C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00188] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is selected from ;

R ^Gl is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen, and d-C ₃ aikoxy;

R ^Glc is selected from the group consisting of hydrogen, Ci-C alkoxy, Ci-C alkyl,

C -Cscycloalkyl, and halogen; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L ¹ is a bond or QR'R ² );

R ¹ and R ² and the carbon atom to which they are attached form a C ₃ -C ₅ cycloalkylene;

G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1, 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen;

L ² is -CH ₂ CH ₂ CH ₂ -;

G ³ is -C0 ₂ H;

L ³ is selected from the group consisting of -(CH ₂ ) _{4 5} -,

-(CH ₂ ) _{3 4} -(CR ³ R ⁴ )-, -CH ₂ CH ₂ -X ³ -(CRVV ₂ -, and -CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Qalkyl, and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

X ³ is O; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen and Ci-C alkyl; or

R ⁿ and R ¹² and the carbon to which they are attached form a Q-Cecycloalkylene, wherein the Q-Cecycloalkylene is optionally fused to a phenyl ring. [00189] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is selected from

R ^Gl is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Ci-C ₃ alkoxy, Ci-C ₃ alkyl,

C ₃ -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is selected from the group consisting of 2-furanyl and 2-thiophenyl; wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 or 2 substituents independently selected from halogen or C ₁ -C ₃ alkyl, wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is -C0 ₂ H;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ )i_ ₃ - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{! 2} -, -(CH^ .Otai-CCH^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Qalkyl, -(Q-Qalkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a Q-Qcycloalkylene; G is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Cealkyl, C ₂ -C ₆ aikenyl, C ₂ -C ₆ aikynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Ci-Cehaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Cealkyl or Ci-Cehaloalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and

Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Ci-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl,

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Ci-Cealkyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00190] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is selected from ; wherein

R ^Gl is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are C C ₃ alkoxy;

R ^Glc is selected from the group consisting of Ci-C alkoxy and halogen;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L is a bond;

G ² is selected from the group consisting of 2-furanyl and 2-thiophenyl; wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 Q-Qalkyl; L ² is -CH ₂ CH ₂ CH ₂ -;

G ³ is -C0 ₂ H; and

L ³ is -(CH ₂ ) _{4 5} -.

[00191] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is ; wherein

R ^Gl is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are C C ₃ alkoxy;

R ^Glc is selected from the group consisting of Ci-C ₃ alkoxy and halogen;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L ¹ is a bond;

G ² is selected from the group consisting of 2-furanyl and 2-thiophenyl; wherein the 2-furanyl and 2-thiophenyl are unsubstituted or optionally substituted with 1 Ci-C ₃ alkyl;

L ² is -CH H ₂ CH ₂ -;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and

Q-Ceaikyl; and

one R ⁶ is selected from the group consisting of hydrogen and Q-Cealkyl.

[00192] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is selected from

R ^Gl is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Ci-C ₃ alkoxy, and halogen; wherein Ci-C alkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Ci-C alkoxy, Ci-C alkyl,

C -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen; L ¹ is a bond or QI^R ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Ci-C alkoxy, Ci-C alkyl and oxo; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1, 2 or 3 substituents independently selected from Ci-C alkoxy, Ci-C alkyl, or halogen, wherein the Ci-C alkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Ci-C alkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Ci-C alkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -P(0)(OH) ₂ , -P(0)(OH)(OQ-Qaikyl), and -P(0)(CH ₃ )(OH);

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{1 2} -, -(CH^ .ClfcCH-CCH,) _{! 2} - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Qalkyl, -(Q-Qalkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a Q-Qcycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Qalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, Q-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Qalkyl, or Q-Qhaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Qalkyl or Q-Qhaloalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Qalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Qalkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Qalkyl; R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Ci-Cealkyl, and -(Ci-C ₆ alkylenyl)-G ^B ; or

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Ci-Cealkyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00193] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is selected from ; wherein

R ^Gl is hydrogen;

R ^Glb and R ^Gld are each Q-Qalkoxy;

R ^Glc is selected from the group consisting of hydrogen and Q-Qalkyl;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L is a bond;

G ² is phenyl;

L ² is -CH ₂ CH ₂ CH ₂ -;

G ³ is -P(0)(OH) ₂ ;

L ³ is selected from the group consisting of -(CH ₂ ) _{4 5} -, -(CH ₂ ) _{3 4} -(CR ³ R ⁴ )-, and -CH ₂ CH ₂ -X ³ -

R ³ and R ⁴ are selected from the group consisting of hydrogen and Q-Qalkyl, wherein one of R ³ and R ⁴ is other than hydrogen;

R ⁹ and R ¹⁰ are each hydrogen; and

X ³ is O.

[00194] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is selected from

R ^Gl is selected from the group consisting of hydrogen and fluorine; R and R are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Q-Qalkoxy, Q-Qalkyl,

C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Ci-C alkoxy, Ci-C alkyl and oxo; wherein the Ci-C alkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -C(0)NHS0 ₂ R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , and - OC(0)NHS0 ₂ R ^G3a ;

R ^G3a is Q-Qalkyl, Q-Qhaloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Q-Qalkyl, Q-Qalkenyl, Q-Qalkynyl, halogen, Q-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Qalkyl, or Q-Qhaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Qalkyl or Q-Qhaloalkyl;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -Oi ₂ CH ₂ -X ³ -(QlVV2-, -(CH^ ^CH^H-fC^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-; R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and

Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Ci-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl,

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00195] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

selected from ; wherein

R ^Gl is hydrogen;

R ^Glb and R ^Gld are each Q-Qalkoxy;

R ^Glc is d-Qalkyl;

L is a bond;

G ² is phenyl;

L ² is -CH ₂ CH ₂ CH ₂ -;

G ³ is -OC(0)NHS0 ₂ R ^G3a ;

R ^G3a is d-Cgalkyl; and

L ³ is -(CH ₂ ) _{2 3} -. [00196] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is selected from

R ^Gl is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Ci-C ₃ alkoxy, Ci-C ₃ alkyl,

C ₃ -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1, 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of

L ³ is selected from the group consisting of -(CH ₂ ) ₂ _ ₅ -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ )i_ ₃ - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{! 2} -, -(CH^ .ClfcCH-CCH,) _{! 2} - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Ceaikyl, -(Q-Ceaikylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Ceaikyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Ci-Cehaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Ceaikyl or Ci-Cehaloalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Q-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl,

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the Q-Cecycloalkylene is optionally fused to a phenyl ring. [00197] In one embodiment in a compound or pharmaceutically acceptable salt of formula (I),

G ¹ is selected from

R ^Gl is selected from the group consisting of hydrogen and fluorine;

R ^Glb and R ^Gld are independently selected from the group consisting of hydrogen,

Q-Qalkoxy, and halogen; wherein Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glc is selected from the group consisting of hydrogen, Ci-C ₃ alkoxy, Ci-C ₃ alkyl,

C ₃ -Cscycloalkyl, halogen, and -N0 ₂ ; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

wherein at least one of R ^Glb , R ^Glc , and R ^Gld is other than hydrogen;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Q-Qalkoxy, Q-Qalkyl and oxo; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1, 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - ally be attached with a methylene bridge to G ² ;

G ³ is ;

LL ³³ iiss sseelleecctteedd ffrroomi the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} -

(CH ₂ )-, -(CR ⁷ R ⁸ )! 4-(CH ₂ )-, ¾CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _1-2 -, -(CH ₂ ) _1-2 CH=CH-(CH ₂ ) _1-2 - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Qalkyl, -(Q-Qalkylenyl)

G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a Q-Qcycloalkylene; G is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ^u , at each occurrence, is independently Q-Cealkyl, C ₂ -C ₆ aikenyl, C ₂ -C ₆ aikynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Ci-Cehaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Cealkyl or Ci-Cehaloalkyl;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected from the group consisting of hydrogen and Ci-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl,

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Ci-Cealkyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00198] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from the roup consisting of

; wherein

R ^Gle and R ^G " are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and -NHC(0)R ^x ; wherein the Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^x is Q-Qalkyl; wherein the Q- aikyl is unsubstituted or optionally substituted with one, two or three fluorines; R ⁸ is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glh and R ^Gli are independently selected from the group consisting of hydrogen, Q-Qalkoxy, and Q-Qalkyl; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glj is selected from the group consisting of hydrogen or halogen;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Ci-C alkoxy, Ci-C alkyl and oxo; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1 , 2 or 3 substituents independently selected from Q-Qalkoxy, Q-Qalkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -C0 ₂ H, -P(0)(OH) ₂ , -P(0)(OH)(OQ-Qaikyi), - P(0)(CH ₃ )(OH), -C(0)NHS0 ₂ R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , and - OC(0)NHS0 ₂ R ^G3a ;

R ^G3a is Q-Qalkyl, Q-Qhaloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Q-Qalkyl, Q-Qalkenyl, Q-Qalkynyl, halogen, Q-Qhaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Q-Qalkyl, or Q-Qhaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Q-Qalkyl or Q-Qhaloalkyl;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -Oi ₂ CH ₂ -X ³ -(QlVV2-, -(CH^ ^CH^H-fC^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-; R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and

Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

R ⁷ and R ⁸ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl,

R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloaikylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00199] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from the roup consisting of

; wherein

R ^Gle and R ^G " are each C C ₃ alkoxy;

R ^Glh and R ^Gli are each C C ₃ alkoxy;

R ^Glj is hydrogen;

L ¹ is a bond;

G ² is phenyl;

L ² is -CH ₂ CH ₂ CH ₂ -;

G ³ is -C0 ₂ H; and

L ³ is -(CH ₂ ) _{4 5} -. [00200] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from the roup consisting of

R and R are independently selected from the group consisting of hydrogen and fluorine;

R ^Glm , R ^G1 °, R ^Glp R ^Glq , and R ^Gls are independently selected at each occurrence from the group consisting of hydrogen and Q-Qalkyl; wherein the Q-Qalkyl is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Gln is selected from the group consisting of halogen and Q-Qalkoxy; wherein the

Q-Qalkoxy is unsubstituted or optionally substituted with one, two, or three fluorines;

R ^Glr is independently selected at each occurrence from the group consisting of hydrogen, Q- C ₃ alkoxy, Q-Qalkyl, C ₃ -C ₅ cycloalkyl, halogen, and -N0 ₂ ; wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one hydroxy or one, two, or three fluorines;

one of X ¹ and X ² is O and the other is CH;

m is one, two or three;

n is one, two or three;

L ¹ is a bond or QR^ ² );

R ¹ and R ² are independently selected from the group consisting of hydrogen, Ci-C alkoxy, and Q-Qalkyl; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines; or

R ¹ and R ² and the carbon atom to which they are attached form a Q-Qcycloalkylene or oxetane; wherein the Q-Qcycloalkylene is unsubstituted or optionally substituted with one, two, or three substituents selected from Ci-C alkoxy, Ci-C alkyl and oxo; wherein the Ci-C alkyl and Ci-C alkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

G ² is phenyl; wherein the phenyl is unsubstituted or optionally substituted with 1, 2 or 3 substituents independently selected from Q-Qalkoxy, C ₁ -C ₃ alkyl, or halogen, wherein the Q-Qalkyl and Q-Qalkoxy are unsubstituted or optionally substituted with one, two, or three fluorines;

L ² is -CH ₂ CH ₂ CH ₂ -, wherein the -CH ₂ CH ₂ CH ₂ - is unsubstituted or optionally substituted with Q-Qalkyl, wherein the -CH ₂ CH ₂ CH ₂ - or Q-Qalkyl substituent are each independently optionally substituted with one, two, or three fluorines, and wherein the central carbon of - CH ₂ CH ₂ CH ₂ - can optionally be attached with a methylene bridge to G ² ;

G ³ is selected from the group consisting of -C0 ₂ H, -P(0)(OH) ₂ , -P(0)(OH)(OCi-C ₆ alkyl), - P(0)(CH ₃ )(OH), -C(0)NHS0 ₂ R ^G3a , -C(0)NHS0 ₂ NHR ^G3a , -NHS0 ₂ NHC(0)R ^G3a , and - OC(0)NHS0 ₂ R ^G3a ;

R ^G3a is d-Cgalkyl, Q-Cghaloalkyl, or G ^A ;

G ^A is cycloalkyl, cycloalkenyl, aryl, or heteroaryl, each of which is independently unsubstituted or substituted with 1, 2, or 3 independently selected R ^u groups; wherein

R ^u , at each occurrence, is independently Ci-Cealkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, halogen, d-Cghaloalkyl, -CN, oxo, -N0 ₂ , -OR ^J , -OC(0)R ^k , -OC(0)N(R ^J ) ₂ , -S(0) ₂ R ^J , -S(0) ₂ N(R ^J ) ₂ , -C(0)R ^k , -C(0)OR ^J , -C(0)N(R ^J ) ₂ , -N(R ^J )C(0)R ^k , -N(R ^J )S(0) ₂ R ^k , -N(R ^J )C(0)0(R ^k ), or -N(R ^J )C(0)N(R ^J ) ₂ ;

R ^J , at each occurrence, is independently selected from the group consisting of hydrogen, Ci-Ceaikyl, or Q-Cehaloalkyl;

R ^k , at each occurrence, is independently selected from the group consisting of Ci-Ceaikyl or Q-Qhaloalkyl;

L ³ is selected from the group consisting of -(CH ₂ ) _{2 5} -, -(CH ₂ ) _{1 4} -(CR ³ R ⁴ )-, -(CH ₂ )-(CR ⁵ R ⁶ ) _{1 3} - (CH ₂ )-, -(CR ⁷ R ⁸ ) _! 4-(CH ₂ )-, -CH ₂ CH ₂ -X ³ -(CR ⁹ R ¹⁰ ) _{1 2} -, -(CH^ ^CH^H-iC^ ₂ - and

-CH ₂ C(0)NH(CR ⁿ R ¹² )-;

R ³ and R ⁴ are selected from the group consisting of hydrogen, Q-Cealkyl, -(Q-Cealkylenyl)- G ^B , and hydroxy, wherein one of R ³ and R ⁴ is other than hydrogen; or

R ³ and R ⁴ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene;

G ^B is aryl or heteroaryl, each of which is independently unsubstituted or substituted with 1 , 2, or 3 independently selected R ^u groups;

R ⁵ is independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cgalkyl;

one R ⁶ is hydroxy, and any additional R ⁶ is independently selected, at each occurrence, from the group consisting of hydrogen and Q-Cealkyl;

R ⁷ and R ⁸ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl;

R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Ci-Cealkyl; or

one R ⁹ and R ¹⁰ and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene and any additional R ⁹ and R ¹⁰ are independently selected, at each occurrence, from the group consisting of hydrogen and Q-Ceaikyl;

X ³ is O, S, or S(0)i _-2 ; and

R ⁿ and R ¹² are independently selected from the group consisting of hydrogen, Q-Ceaikyl, R ⁿ and R ¹² and the carbon to which they are attached form a C ₃ -C ₆ cycloalkylene, wherein the C ₃ -C ₆ cycloalkylene is unsubstituted or optionally substituted with one, two or three Q-Ceaikyl or the C ₃ -C ₆ cycloalkylene is optionally fused to a phenyl ring.

[00201] In one embodiment, in a compound or pharmaceutically acceptable salt of formula (I), G ¹ is selected from the group consisting of

; wherein

R ^1K and R ^G11 are independently selected from the group consisting of hydrogen and fluorine; L ¹ is a bond;

G ² is phenyl;

L ² is -CH ₂ CH ₂ CH ₂ -;

G ³ is -CO ₂ H; and

[00202] Specific embodiments contemplated as part of the present disclosure also include, but are not limited to, compounds or pharmaceutically acceptable salts of formula (I), as defined, for example:

[00203] 2- { [N-(3 ,5 -dimethoxy-4-methylbenzoyl)-N-(3 -phenylpropyl)glycyl] amino } -2,3 - dihydro- 1 H-indene-2-carboxylic acid;

[00204] l-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3- phenylpropyl)glycyl] amino } cyclohexane- 1 -carboxylic acid;

[00205] l-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3- phenylpropyl)glycyl] amino } cyclopropane- 1 -carboxylic acid;

[00206] 5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino]pentanoic acid;

[00207] 6- [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino]hexanoic acid;

[00208] {2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]eth oxy}acetic acid;

[00209] 5 - [(3 , 5 -dimethoxybenzoyl)(3 -phenylpropyl) amino] pentanoic acid;

[00210] 5-{ [ 1 -(4-methoxyphenyl)cyclopropane-l -carbonyl] (3-phenylpropyl)amino jpentanoic acid;

[00211] 5-{ [(3,5-dimethoxyphenyl)acetyl](3-phenylpropyl)amino}pentanoic acid;

[00212] 5-[(3-phenylpropyl)(3,4,5-trimethoxybenzoyl)amino]pentanoic acid;

[00213] 5 - { (3 ,5 -dimethoxy-4-methylbenzoyl) [3 -(3 -methylphenyl)propyl] amino } pent acid;

[00214] 5 - [(3 , 5 -dichlorobenzoyl)(3 -phenylpropyl) amino] pentanoic acid; [00215] 5-[(3,5-difluoro-4-methoxybenzoyl)(3-phenylpropyl)amino]pent anoic acid;

[00216] 5-[(2-ethoxypyridine-4-carbonyl)(3-phenylpropyl)amino]pentan oic acid;

[00217] {2-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]ethoxy}aceti c acid;

[00218] 5-[(3,5-dichloro-4-methylbenzoyl)(3-phenylpropyl)amino]penta noic acid;

[00219] 5-[(4-chloro-3-methoxybenzoyl)(3-phenylpropyl)amino]pentanoi c acid;

[00220] 5-[(3,5-diethoxybenzoyl)(3-phenylpropyl)amino]pentanoic acid;

[00221] 5-[(3,5-dimethoxy-2-nitrobenzoyl)(3-phenylpropyl)amino]penta noic acid;

[00222] 5-[(4-bromo-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]penta noic acid;

[00223] 5 - [(3 -phenylpropyl) (3,4,5 -triethoxybenzoyl) amino] pentanoic acid;

[00224] 5 - [(3 -methoxy-4-nitrobenzoyl) (3 -phenylpropyl)amino] pentanoic acid;

[00225] 5-[(3,4-dihydro-2H-l,5-benzodioxepine-7-carbonyl)(3- phenylpropyl) amino] pentanoic acid;

[00226] 5-[(7-methoxy-l-benzofuran-5-carbonyl)(3-phenylpropyl)amino] pentanoic acid;

[00227] 5 - [(3 -phenylpropyl) { 1 - [4-(trifluoromethoxy)phenyl] cyclopropane- 1 - carbonyl }amino]pentanoic acid;

[00228] 5-{(3-phenylpropyl)[3-(trifluoromethoxy)benzoyl]amino}pentan oic acid;

[00229] 5-{ [ 1 -(2H-1 ,3-benzodioxol-5-yl)cyclopropane- 1 -carbonyl] (3- phenylpropyl) amino } pentanoic acid;

[00230] 5-[(3-methoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pentanoi c acid;

[00231] 5-{ [3-methoxy-5-(trifluoromethoxy)benzoyl](3-phenylpropyl)amino }pentanoic acid;

[00232] 5-[(2,4-difluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino] pentanoic acid;

[00233] 5-[(4-methoxy-2-methyl-l-benzofuran-6-carbonyl)(3-phenylprop yl)amino]pentanoic acid;

[00234] 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(2-fluorophenyl)propyl] amino}pentanoic acid;

[00235] 5- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(3 -fluorophenyl)propyl] amino } pentanoic acid;

[00236] 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4-fluorophenyl)propyl] amino}pentanoic acid;

[00237] 5-[(4-cyclopropyl-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino ]pentanoic acid;

[00238] 5-{ [3-(4-chlorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl)ami no}pentanoic acid;

[00239] 5-{ [3,5-dimethoxy-4-(trifluoromethyl)benzoyl](3-phenylpropyl)am ino}pentanoic acid; [00240] 5-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl)ami no}pentanoic acid;

[00241] 5-[(2-chloro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pent anoic acid;

[00242] 5-[(3,5-dimethoxy-4-methylbenzoyl){3-[3- (trifluoromethyl)phenyl] propyl } amino] pentanoic acid;

[00243] 5- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(5 -methylthiophen-2- yl)propyl] amino} pentanoic acid;

[00244] 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4-methylphenyl)propyl] amino}pentanoic acid;

[00245] 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4-methoxyphenyl)propyl ]amino}pentanoic acid;

[00246] ({2-[(3,5-dimethoxy-4-methylbenzoyl)(3^henylpropyl)arnino]et hyl}sulfanyl)acetic acid;

[00247] N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycyl-2 -methylalanine;

[00248] N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycylph enylalanine;

[00249] N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycyl-3 -thiophen-2- ylalanine;

[00250] 5-[(2,6-dimethoxypyridine-4-carbonyl)(3-phenylpropyl)amino]p entanoic acid;

[00251] 5-{ [3-(2,4-dichlorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}pentanoic acid;

[00252] ({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy} me thyl)phosphonic acid;

[00253] N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycylgl ycine;

[00254] 2-benzyl-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)a mino]pentanoic acid;

[00255] {2-[(3,5-dimethoxy-4-methylbenzoyl)(3^henylpropyl)amino]etha nesulfinyl}acetic acid;

[00256] 5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] -2-methylpentanoic acid;

[00257] 2-{2-[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethoxy } -2- methylpropanoic acid;

[00258] 3-{2-[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethoxy } propanoic acid;

[00259] 5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] -2,2-dimethylpentanoic acid;

[00260] 5-[(2-fluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pent anoic acid; [00261] l-({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy } methyl)cyclopropane- 1 -carboxylic acid;

[00262] 3-({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethyl }sulf any l)propanoic acid;

[00263] l-[({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethyl } sulf anyl)methyl] cyclopropane- 1 -carboxylic acid;

[00264] 3-({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethyl} sulf any l)butanoic acid;

[00265] 5- { [ 1 -(5 -methoxypyridin-2-yl)cyclopropane- 1 -carbonyl] (3- phenylpropyl) amino jpentanoic acid;

[00266] 5-{(3-phenylpropyl)[l-(pyridin-4-yl)cyclopropane-l-carbonyl] amino}pentanoic

[00267] 5-[(6-methoxy-lH-indole-3-carbonyl)(3-phenylpropyl)amino]pen tanoic acid;

[00268] 5-{ [(2R)-2-methoxy-2-(4-methoxyphenyl)acetyl](3-phenylpropyl)am ino}pentan acid;

[00269] N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)-beta-al anine;

[00270] 3,5-dimethoxy-4-methyl-N-{3-[(methylsulfamoyl)amino]-3-oxopr opyl}-N-(3- phenylpropyl)benzamide;

[00271 ] 4- [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] butanoic acid;

[00272] 3,5-dimethoxy-4-methyl-N-{5-[(methylsulfamoyl)amino]-5-oxope ntyl}-N-(3- phenylpropyl)benzamide;

[00273] {4-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]but yl}phosphonic

[00274] {5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pen tan-2- yljphosphonic acid;

[00275] l-(4-methoxyphenyl)-N-{5-[(methylsulfamoyl)amino]-5-oxopenty l}-N-(3- phenylpropyl)cyclopropane- 1 -carboxamide ;

[00276] 3 ,5 -dimethoxy-N- { 5 - [(methylsulf amoyl) amino] -5 -oxopentyl } -N-(3 - phenylpropyl)benzamide;

[00277] { 4- [(3 , 5 -dimethoxybenzoyl) (3 -phenylpropyl)amino] butyl } phosphonic acid;

[00278] ethyl hydrogen {4-[(3,5-dimethoxybenzoyl)(3- phenylpropyl) amino] butyl } phosphonate ;

[00279] (-) -(2R) -5 - [(3 , 5 -dimethoxy-4-me thy lbenzoyl)(3 -phenylpropyl) amino] -2- methylpentanoic acid;

[00280] (+)-(25)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)a mino]-2- methylpentanoic acid;

[00281 ] 5 - [(3 -fluoro-4-methoxybenzoyl) (3 -phenylpropyl)amino]pentanoic acid; [00282] 5-[(2H-l,3-benzodioxole-5-carbonyl)(3-phenylpropyl)amino]pen tanoic acid;

[00283] 5-[(4-fluoro-3-methoxybenzoyl)(3-phenylpropyl)amino]pentanoi c acid;

[00284] 5-{ [l-(3-methoxyphenyl)cyclopropane-l-carbonyl](3-phenylpropyl) amino}pentanoic acid;

[00285] 5-[(3,4-dimethoxybenzoyl)(3-phenylpropyl)amino]pentanoic acid;

[00286] 5-[(4-methoxybenzoyl)(3-phenylpropyl)amino]pentanoic acid;

[00287] 5-{ [2-(4-methoxyphenyl)-2-methylpropanoyl](3-phenylpropyl)amino }pentanoic acid;

[00288] 5-{ [ 1 -(4-methoxyphenyl)cyclobutane- 1 -carbonyl](3-phenylpropyl)amino jpentanoic acid;

[00289] (2- { [ 1 -(4-methoxyphenyl)cyclopropane- 1 -carbonyl] (3- phenylpropyl) amino } ethoxy) acetic acid;

[00290] 5 - { [4-(2-hydroxyethoxy) -3,5 -dimethoxybenzoyl] (3 -phenylpropyl)amino } pentanoic acid;

[00291] 5-{ [3-(4-methoxyphenyl)oxetane-3-carbonyl](3-phenylpropyl)amino }pentanoic acid;

[00292] 5-{(3,5-dimethoxybenzoyl)[3-(3-fluorophenyl)propyl]amino}pen tanoic acid;

[00293] 5 - { [3 -(3 -chlorophenyl)propyl] (3,5 -dimethoxybenzoyl) amino } pentanoic acid;

[00294] 5- { [3-(3 -fluorophenyl)propyl] [ 1 -(4-methoxyphenyl)cyclopropane- 1 - carbonyl] amino} pentanoic acid;

[00295] 2-{3-[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] propyl } hexanoic acid;

[00296] 2-{3-[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] propyl } -2- methylhexanoic acid;

[00297] 5 - [(3 , 5 -dimethoxybenzoyl)(3 -phenylpropyl) amino] -2-methylpentanoic acid;

[00298] 5-[(4-fluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pent anoic acid;

[00299] ({2-[(4-fluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]et hyl}sulfanyl)acetic acid;

[00300] ({2-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]ethyl}sulfa nyl)acetic acid;

[00301] 5- { [3-(3 -chlorophenyl)propyl] [ 1 -(4-methoxyphenyl)cyclopropane- 1 - carbonyl] amino} pentanoic acid;

[00302] 5- { [ 1 -(2-fluoro-4-methoxyphenyl)cyclopropane- 1 -carbonyl] (3- phenylpropyl) amino } pentanoic acid;

[00303] 1 - { [N-(3 ,5 -dimethoxy-4-methylbenzoyl)-N-(3 -phenylpropyl)glycyl] amino } -4- ethylcyclohexane-1 -carboxylic acid;

[00304] 5 - { [ 1 -(3 -fluoro-4-methoxyphenyl)cyclopropane- 1 -carbonyl] (3 - phenylpropyl) amino } pentanoic acid; [00305] 5-{ [l-(4-methoxyphenyl)cyclopentane-l-carbonyl](3-phenylpropyl) amino}pentanoic acid;

[00306] 5 - { [ 1 -(3 -chloro-4-methoxyphenyl)cyclopropane- 1 -carbonyl] (3 - phenylpropyl) amino jpentanoic acid;

[00307] 5-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]-2,2-dimethyl pentanoic acid;

[00308] (2-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid;

[00309] (2- { (3 , 5 -dimethoxy-4-methylbenzoyl) [3 -(2-fluorophenyl)propyl] amino } ethoxy)acetic acid;

[00310] N-{5-[(methanesulfonyl)amino]-5-oxopentyl}-3,5-dimethoxy-4-m ethyl-N-(3- phenylpropyl)benzamide;

[00311] [(2-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetic acid;

[00312] [(2-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetic acid;

[00313] [(2-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetic acid;

[00314] [(2-{ [l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl)amino}ethyl)sulfanyl]acetic acid;

[00315] [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(2- fluorophenyl)propyl] amino } ethyl) sulf anyl] acetic acid;

[00316] [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(3- fluorophenyl)propyl] amino } ethyl) sulf anyl] acetic acid;

[00317] [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4- fluorophenyl)propyl] amino } ethyl) sulf anyl] acetic acid;

[00318] N-{5-[(cyclopropanesulfonyl)amino]-5-oxopentyl}-3,5-dimethox y-4-methyl-N-(3- phenylpropyl)benzamide;

[00319] (4R)-5 -[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl)amino] -4- hydroxypentanoic acid;

[00320] (3E)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino ]pent-3-enoic acid;

[00321] [(2-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetic acid;

[00322] N- { 5 -[(ethanesulfonyl)amino] -5 -oxopentyl } -3 ,5 -dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide;

[00323] 3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(propane-2-sulfonyl)amino ]pentyl}-N-(3- phenylpropyl)benzamide; [00324] [(2-{ [3-(3,5-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetic acid;

[00325] 5-{ [3-(3,5-difluorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}pentanoic acid;

[00326] (2-{ [3-(3,5-dichlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid;

[00327] (2-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid;

[00328] (2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(3-fluorophenyl)propyl ]amino}ethoxy)acetic acid;

[00329] (2-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid;

[00330] (2-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid;

[00331] [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } ethyl)sulfanyl] acetic acid;

[00332] 5-{(3,5-dimethoxybenzoyl)[3-(5-methylfuran-2-yl)propyl]amino }pentanoic acid;

[00333] 5- { (3 ,5 -dimethoxybenzoyl) [3-(2-fluorophenyl)propyl] amino jpentanoic acid;

[00334] 5-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pentan oic acid;

[00335] 5-{ [3-(3,5-difluorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pe ntanoic acid;

[00336] 5-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pe ntanoic acid;

[00337] 5- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(5 -methylfuran-2-yl)propyl] amino jpentanoic acid;

[00338] (2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4-fluorophenyl)propyl ]amino}ethoxy)acetic acid;

[00339] N- { 5 -[(4-fluorobenzene- 1 -sulfonyl)amino] -5 -oxopentyl } -3 ,5 -dimethoxy-4-methyl-N-

(3 -phenylpropyl)benzamide ;

[00340] 3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(pyridine-2-sulfonyl)amin o]pentyl}-N-(3- phenylpropyl)benzamide;

[00341] 3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(pyridine-3-sulfonyl)amin o]pentyl}-N-(3- phenylpropyl)benzamide;

[00342] 3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(pyridine-4-sulfonyl)amin o]pentyl}-N-(3- phenylpropyl)benzamide;

[00343] N-{5-[(benzenesulfonyl)amino]-5-oxopentyl}-3,5-dimethoxy-4-m ethyl-N-(3- phenylpropyl)benzamide; [00344] 3 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino]propyl (4- fluorobenzene- 1 -sulfonyl)carbamate;

[00345] 5-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}pentanoic acid;

[00346] 5-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}pentanoic acid;

[00347] 5- { (3 ,5 -dimethoxybenzoyl) [3-(4-fluorophenyl)propyl] amino jpentanoic acid;

[00348] 5-{ [2-ethoxy-l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid;

[00349] 3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(trifluoromethanesulfonyl )amino]pentyl}-N-(3- phenylpropyl)benzamide;

[00350] 5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] -2-hydroxypentanoic acid;

[00351 ] 5 - { [ 1 -(4-methoxyphenyl) -3 -oxocyclobutane- 1 -carbonyl] (3 - phenylpropyl) amino jpentanoic acid;

[00352] 5-{(3,5-dimethoxy-4-methylbenzoyl)[(2R)-4-phenylbutan-2-yl]a mino}pentanoic acid;

[00353] 5-{(3,5-dimethoxy-4-methylbenzoyl)[(25)-4-phenylbutan-2-yl]a mino}pentanoic acid;

[00354] 5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] -2-hydroxy-2- methylpentanoic acid;

[00355] N-[2-( { 1 - [(methanesulfonyl)amino] -2-methyl- 1 -oxopropan-2-yl } oxy)ethyl] -3,5- dimethoxy-4-methyl-N-(3 -phenylpropyl)benzamide ;

[00356] N-(2- { 2- [(methanesulfonyl)amino] -2-oxoethoxy } ethyl)-3 ,5 -dimethoxy-4-methyl-N-

(3 -phenylpropyl)benzamide ;

[00357] 5-{ [cis -3 -methoxy- 1 -(4-methoxyphenyl)cyclobutane- 1 -carbonyl] (3- phenylpropyl) amino jpentanoic acid;

[00358] 5- { [trans-3 -methoxy- 1 -(4-methoxyphenyl)cyclobutane- 1 -carbonyl] (3- phenylpropyl) amino jpentanoic acid;

[00359] 5 - [(2-methyl-4-oxo-3 ,4-dihydroquinazoline- 8 -carbonyl) (3 - phenylpropyl) amino] pentanoic acid;

[00360] N-{5-[(methanesulfonyl)amino]-4-methyl-5-oxopentyl}-3,5-dime thoxy-4-methyl-N- (3 -phenylpropyl)benzamide ;

[00361] N-{5-[(methanesulfonyl)amino]-4,4-dimethyl-5-oxopentyl}-3,5- dimethoxy-4-methyl- N-(3 -phenylpropyl)benzamide ;

[00362] 5-[(2,6-dimethoxypyrimidine-4-carbonyl)(3-phenylpropyl)arnin o]pentanoic acid;

[00363] 5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino]hexanoic acid; [00364] 5-[(4-cyclopropyl-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino ]-2- hydroxypentanoic acid;

[00365] 3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)-N-[4-(lH-tetrazol- 5- yl) butyl] benzamide ;

[00366] 5-[(5-chloro-2-methylpyrimidine-4-carbonyl)(3-phenylpropyl)a mino]pentanoic acid;

[00367] 5-[(6-fluoro-2-oxo-l,2,3,4-tetrahydroquinoline-4-carbonyl)(3 - phenylpropyl) amino] pentanoic acid;

[00368] 5-[(2-methyl-l-oxo-l,2-dihydroisoquinoline-4-carbonyl)(3- phenylpropyl) amino] pentanoic acid;

[00369] 5-[(7-fluoro-2-oxo-l,2,3,4-tetrahydroquinoline-4-carbonyl)(3 - phenylpropyl) amino] pentanoic acid;

[00370] 5-[(2-acetamidopyridine-4-carbonyl)(3-phenylpropyl)amino]pen tanoic acid;

[00371] 5-[(3,6-dimethyl[l,2]oxazolo[5,4-b]pyridine-4-carbonyl)(3- phenylpropyl) amino] pentanoic acid;

[00372] 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(furan-2-yl)propyl]amin o}pentanoic acid;

[00373] 5- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(5 -methylfuran-2-yl)propyl] amino } -2- hydroxy-2-methylpentanoic acid;

[00374] 5-{(2,4-difluoro-3,5-dimethoxybenzoyl)[3-(5-methylfuran-2- yl)propyl] amino} pentanoic acid;

[00375] 5-{(3,5-diethoxybenzoyl)[3-(5-methylfuran-2-yl)propyl]amino} pentanoic acid;

[00376] 5-{ [3,5-dimethoxy-4-(trifluoromethyl)benzoyl] [3-(5-methylfuran-2- yl)propyl] amino} pentanoic acid;

[00377] 5 - { (4-cyclopropyl-3 , 5 -dimethoxybenzoyl) [3 -(5 -methylfuran-2- yl)propyl] amino} pentanoic acid;

[00378] 5- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(5 -methylfuran-2-yl)propyl] amino } -2- methylpentanoic acid;

[00379] 5- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(5 -methylfuran-2-yl)propyl] amino } -2,2- dimethylpentanoic acid;

[00380] 3,5-dimethoxy-4-methyl-N-{ [(2R)-5-oxooxolan-2-yl]methyl}-N-(3- phenylpropyl)benzamide;

[00381 ] 5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylbutyl)amino] pentanoic acid;

[00382] 2- [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethyl (4-fluorobenzene-

1 -sulfonyl)carbamate;

[00383] 2- [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethyl

(methanesulfonyl)carbamate; [00384] 5-{ [3-(5-chlorofuran-2-yl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}pentanoic acid; and

[00385] 3 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino]propyl

(methanesulfonyl)carbamate.

[00386] Compound names are assigned by using Name 2015 naming algorithm by Advanced Chemical Development or Struct=Name naming algorithm as part of CHEMDRAW® ULTRA v. 12.0.2.1076.

[00387] Compounds of the present disclosure may exist as stereoisomers wherein asymmetric or chiral centers are present. These stereoisomers are "R" or "5" depending on the configuration of substituents around the chiral carbon atom. The terms "R" and "5" used herein are configurations as defined in IUPAC 1974 Recommendations for Section E, Fundamental Stereochemistry, in Pure Appl. Chem., 1976, 45: 13-30. The present disclosure contemplates various stereoisomers and mixtures thereof and these are specifically included within the scope of this disclosure. Stereoisomers include enantiomers and diastereomers, and mixtures of enantiomers or diastereomers. Individual stereoisomers of compounds of the present disclosure may be prepared synthetically from

commercially available starting materials which contain asymmetric or chiral centers or by preparation of racemic mixtures followed by methods of resolution well-known to those of ordinary skill in the art. These methods of resolution are exemplified by (1) attachment of a mixture of enantiomers to a chiral auxiliary, separation of the resulting mixture of diastereomers by

recrystallization or chromatography and optional liberation of the optically pure product from the auxiliary as described in Furniss, Hannaford, Smith, and Tatchell, " Vogel's Textbook of Practical Organic Chemistry", 5th edition (1989), Longman Scientific & Technical, Essex CM20 2JE, England, or (2) direct separation of the mixture of optical enantiomers on chiral chromatographic columns or (3) fractional recrystallization methods.

[00388] Compounds of the present disclosure may exist as cis or trans isomers, wherein substituents on a ring may attached in such a manner that they are on the same side of the ring (cis) relative to each other, or on opposite sides of the ring relative to each other (trans). For example, cyclobutane may be present in the cis or trans configuration, and may be present as a single isomer or a mixture of the cis and trans isomers. Individual cis or trans isomers of compounds of the present disclosure may be prepared synthetically from commercially available starting materials using selective organic transformations, or prepared in single isomeric form by purification of mixtures of the cis and trans isomers. Such methods are well-known to those of ordinary skill in the art, and may include separation of isomers by recrystallization or chromatography.

[00389] It should be understood that the compounds of the present disclosure may possess tautomeric forms, as well as geometric isomers, and that these also constitute an aspect of the present disclosure. [00390] It should be understood that the compounds of the present disclosure that have a carboxylic acid which is substituted with a hydroxy group on the γ-carbon can dehydrate to form a butyrolactone. Under certain biol ed.

[00391] The present disclosure includes all pharmaceutically acceptable isotopically-labelled compounds of formula (I) wherein one or more atoms are replaced by atoms having the same atomic number, but an atomic mass or mass number different from the atomic mass or mass number which predominates in nature. Examples of isotopes suitable for inclusion in the compounds of the disclosure include isotopes of hydrogen, such as ² H and ³ H, carbon, such as ⁿ C, ¹³ C and ¹⁴ C, chlorine, such as 36 CI, fluorine, such as 18 F, iodine, such as 123 l and 12 I, nitrogen, such as 13 N and 1 N, oxygen, such as 1 O, 17 O and 18 O, phosphorus, such as 32 P, and sulfur, such as 35 S. Certain isotopically- labelled compounds of formula (I), for example, those incorporating a radioactive isotope, are useful in drug and/or substrate tissue distribution studies. The radioactive isotopes tritium, i.e. ³ H, and carbon- 14, i.e. ¹⁴ C, are particularly useful for this purpose in view of their ease of incorporation and ready means of detection. Substitution with heavier isotopes such as deuterium, i.e. ² H, may afford certain therapeutic advantages resulting from greater metabolic stability, for example, increased in vivo half-life or reduced dosage requirements, and hence may be preferred in some

circumstances. Substitution with positron emitting isotopes, such as 11 C, 18 F, 15 O and 13 N, can be useful in Positron Emission Topography (PET) studies for examining substrate receptor

occupancy. Isotopically-labeled compounds of formula (I) can generally be prepared by conventional techniques known to those skilled in the art or by processes analogous to those described in the accompanying Examples using an appropriate isotopically-labeled reagents in place of the non- labeled reagent previously employed.

[00392] Thus, the formula drawings within this specification can represent only one of the possible tautomeric, geometric, or stereoisomeric forms. It is to be understood that the present disclosure encompasses any tautomeric, geometric, or stereoisomeric form, and mixtures thereof, and is not to be limited merely to any one tautomeric, geometric, or stereoisomeric form utilized within the formula drawings.

[00393] Present compounds may be used in the form of pharmaceutically acceptable salts. The phrase "pharmaceutically acceptable salt" means those salts which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response and the like and are commensurate with a reasonable benefit/risk ratio. [00394] Pharmaceutically acceptable salts have been described in S. M. Berge et al. J.

Pharmaceutical Sciences, 1977, 66: 1-19.

[00395] Compounds of the present disclosure may contain either a basic or an acidic functionality, or both, and can be converted to a pharmaceutically acceptable salt, when desired, by using a suitable acid or base. The salts may be prepared in situ during the final isolation and purification of the compounds of the present disclosure.

[00396] Examples of acid addition salts include, but are not limited to acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, glycerophosphate, hemisulfate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2-hydroxyethansulfonate (isothionate), lactate, malate, maleate, methanesulfonate, nicotinate, 2-naphthalenesulfonate, oxalate, palmitoate, pectinate, persulfate, 3- phenylpropionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, phosphate, glutamate, bicarbonate, p-toluenesulfonate and undecanoate. Also, the basic nitrogen-containing groups can be quaternized with such agents as lower alkyl halides such as, but not limited to, methyl, ethyl, propyl, and butyl chlorides, bromides and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl and diamyl sulfates; long chain halides such as, but not limited to, decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides; arylalkyl halides like benzyl and phenethyl bromides and others. Water or oil- soluble or dispersible products are thereby obtained. Examples of acids which may be employed to form pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, hydrobromic acid, sulfuric acid, and phosphoric acid and such organic acids as acetic acid, fumaric acid, maleic acid, 4-methylbenzenesulfonic acid, succinic acid and citric acid.

[00397] Basic addition salts may be prepared in situ during the final isolation and purification of compounds of this disclosure by reacting a carboxylic acid-containing moiety with a suitable base such as, but not limited to, the hydroxide, carbonate or bicarbonate of a pharmaceutically acceptable metal cation or with ammonia or an organic primary, secondary or tertiary amine. Pharmaceutically acceptable salts include, but are not limited to, cations based on alkali metals or alkaline earth metals such as, but not limited to, lithium, sodium, potassium, calcium, magnesium and aluminium salts and the like and nontoxic quaternary ammonia and amine cations including ammonium,

tetramethylammonium, tetraethylammonium, methylamine, dimethylamine, trimethylamine, triethylamine, diethylamine, ethylamine and the like. Other examples of organic amines useful for the formation of base addition salts include ethylenediamine, ethanolamine, diethanolamine, piperidine, piperazine and the like.

[00398] The term "pharmaceutically acceptable prodrug" or "prodrug" as used herein, represents those prodrugs of the compounds of the present disclosure which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans and lower animals without undue toxicity, irritation, allergic response, and the like, commensurate with a reasonable benefit/risk ratio, and effective for their intended use.

[00399] The present disclosure contemplates compounds formed by synthetic means or formed by in vivo biotransformation of a prodrug.

[00400] Compounds described herein can exist in unsolvated as well as solvated forms, including hydrated forms, such as hemi-hydrates. In general, the solvated forms, with pharmaceutically acceptable solvents such as water and ethanol among others are equivalent to the unsolvated forms for the purposes of the present disclosure.

General Synthesis

[00401] The compounds of the present disclosure can be better understood in connection with the following synthetic schemes and methods which illustrate a means by which the compounds can be prepared.

[00402] The compounds of this disclosure can be prepared by a variety of synthetic procedures. Representative procedures are shown in, but are not limited to, Schemes 1-20. In Schemes 1-20, the variables L ¹ , L ² , L ³ , G ¹ , G ² , G ^B , R ¹ , R ² , R ⁹ , R ¹⁰ , R ^G3a are as described in the Summary.

[00403] Abbreviations: Ac for acetyl; Boc ₂ 0 for di-teri-butyl dicarbonate; Bu for butyl; Et for ethyl; CDI for carbonyldiimidazole; DBU for l,8-diazabicyclo[5.4.0]undec-7-ene; HMPA for hexamethylphosphor amide; PyAOP for ((3H-[ 1 ,2,3]triazolo[4,5-¾]pyridin-3-yl)oxy)tri(pyrrolidin- 1 - yl)phosphonium hexafluorophosphate(V); TBAF for tetrabutylammonium fluoride; TBS for tert- butyl(dimethyl)silyl; Tf ₂ 0 for trifluoromethanesulfonic anhydride; and TMS for trimethylsilyl.

Scheme 1

L ²

G NH ₂ 1) H

1 )

' (1 -2)

Hal ¹ "C0 ₂ C _r C ₂ alkyl »- C0 ₂ C _r C ₂ alkyl ~

jl _oc 2) G'-L'-CO _j H

2) Boc ₂ 0

(1-1)

amide coupl 3) hydrolysis

( 1 -5)

[00404] As shown in Scheme 1, compounds of formula (1-5) can be prepared from compounds of formula (1-1). Compounds of formula (1-1); wherein Hal ¹ is chlorine, bromine or iodine; can be reacted with an amine of formula (1-2) heated in a solvent such as acetonitrile for 0.25-24 hours.

Then the intermediate amine can be treated with di-teri-butyl dicarbonate in the presence of a tertiary amine base at ambient temperature for 0.25 to 24 hours to give compounds of formula (1-3) that can be chromatographically purified. Compounds of formula (1-3) can then be reacted in a three-step process to give compounds of formula (1-5). First, the teri-butoxycarbonyl protecting group can be removed by acidic treatment such as trifluoroacetic acid in methylene chloride or hydrochloric acid in dioxane. The exposed amine can then be coupled with a carboxylic acid of formula (1-4) using a reagent such as (l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]py ridinium 3-oxid hexafluorophosphate (HATU) in the presence of a tertiary amine base in a solvent such as N,N- dimethylformamide at ambient temperature over 1 to 24 hours. Alternatively, carboxylic acids of formula (1-4) can be converted to the corresponding acid chlorides by reaction with thionyl chloride, PC1 ₃ , PCI ₅ , cyanuric chloride, or oxalyl chloride. The reactions with thionyl chloride and oxalyl chloride can be catalyzed with N,N-dimethylformamide at ambient temperature in a solvent such as dichloromethane. The resultant acid chlorides can then reacted with the amines derived from carbamates of formula (1-3) optionally in the presence of a base such as a tertiary amine base such as but not limited to triethylamine or diisopropylethylamine or an aromatic base such as pyridine, at room temperature in a solvent such as dichloromethane to give the corresponding amides. Lastly, the ester can be hydrolyzed to the corresponding carboxylic acid using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature to give compounds of formula (1-5). Compounds of formula (1-5) are representative of compounds of formula (I).

Scheme 2

Hal ^{1 "} C0 ₂ C, -C ₂ alkyl

(1-1)

o

L N C0 ₂ H

G

(1-5)

[00405] As shown in Scheme 2, compounds of formula (1-5) can also be prepared from compounds of formula (1-1) without the protection/deprotection sequence described in Scheme 1.

Compounds of formula (1-1); wherein Hal ¹ is chlorine, bromine or iodine; can be reacted with an amine of formula (1-2) heated in a solvent such as acetonitrile for 0.25-24 hours to give compounds of formula (2-1). Compounds of formula (2-1) can then be reacted in a two-step process to give compounds of formula (1-5). First, the amine of formula (2-1) can be coupled with a carboxylic acid of formula (1-4) using a reagent such as (l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-

¾]pyridinium 3-oxid hexafluorophosphate (HATU) in the presence of a tertiary amine base in a solvent such as N,N-dimethylformamide at ambient temperature over 1 to 24 hours. Alternatively, carboxylic acids of formula (1-4) can be converted to the corresponding acid chlorides by reaction with thionyl chloride, PC1 ₃ , PC1 ₅ , cyanuric chloride, or oxalyl chloride. The reactions with thionyl chloride and oxalyl chloride can be catalyzed with N,N-dimethylformamide at ambient temperature in a solvent such as dichloromethane. The resultant acid chlorides can then reacted with the amines of formula (2-1) optionally in the presence of a base such as a tertiary amine base such as but not limited to triethylamine or diisopropylethylamine or an aromatic base such as pyridine, at room temperature in a solvent such as dichloromethane to give the corresponding amides. Then, the ester can be hydrolyzed to the corresponding carboxylic acid using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature to give compounds of formula (1-5).

Compounds of formula (1-5) are representative of compounds of formula (I).

Scheme 3

H ₂

[00406] As shown in Scheme 3, compounds of formula (3-5) can be prepared from compounds of formula (3-1). Compounds of formula (3-1) can be reacted with an acid chloride of formula (3-2); wherein Hal ² is chlorine or bromine; at ambient temperature in a solvent such as dichloromethane for 0.25-6 hours to give compounds of formula (3-3). Compounds of formula (3-3) can then be reacted with amines of formula (1-2) in the presence of a base such as potassium carbonate in a solvent such as acetonitrile at ambient temperature over 1-6 hours to give compounds of formula (3-4). The amine of formula (3-4) can be coupled with a carboxylic acid of formula (1-4) using a reagent such as (1- [bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (HATU) in the presence of a tertiary amine base in a solvent such as N,N-dimethylformamide at ambient temperature over 1 to 24 hours. Alternatively, carboxylic acids of formula (1-4) can be converted to the corresponding acid chlorides as described in Schemes 1 and 2, and then the resultant acid chloride can be reacted with amines of formula (3-4) to give the corresponding amides. Then, the ester can be hydrolyzed to the corresponding carboxylic acid using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature to give compounds of formula (3-5). Compounds of formula (3-5) are representative of compounds of formula (I). Scheme 4

_G 2 ^U NH ₂ 1) G' -L' -C0 ₂ H (1-2) Ll /\ ( 1 -4)

N C0 ₂ C _r C ₂ alkyl ^

H

amide coupling ^ ^ 2) hydrolysis

[00407] As shown in Scheme 4, compounds of formula (3-5) can also be prepared from compounds of formula (4-1). Compounds of formula (4-1), wherein Hal ¹ is chlorine, bromine or iodine; can be reacted with an amines of formula (1-2) heated in a solvent such as acetonitrile in the presence of a base such as potassium carbonate for 2-24 hours to give compounds of formula (4-2). The amines of formula (4-2) can be coupled with a carboxylic acids of formula (1-4) using a reagent such as (l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid

hexafluorophosphate (HATU) in the presence of a tertiary amine base in a solvent such as N,N- dimethylformamide at ambient temperature over 1 to 24 hours. Alternatively, carboxylic acids of formula (1-4) can be converted to the corresponding acid chlorides as described in Schemes 1 and 2, and then the resultant acid chloride can be reacted with amines of formula (4-2) to give the corresponding amides. Then, the ester can be hydrolyzed to the corresponding carboxylic acid using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature or heated in a solvent such as dioxane to give compounds of formula (4-3). Compounds of formula (4-3) can be coupled with compounds of formula (3-1) using a reagent such as (1- [bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (HATU) in the presence of a tertiary amine base in a solvent such as N,N-dimethylformamide at ambient temperature over 1 to 24 hours. Alternatively, carboxylic acids of formula (4-3) can be converted to the corresponding acid chlorides as described in Schemes 1 and 2, and then the resultant acid chloride can be reacted with amines of formula (3-1) to give the corresponding amides. Then, the ester can be hydrolyzed to the corresponding carboxylic acid using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature or heated in a solvent such as dioxane to give compounds of formula (3-5). Compounds of formula (3-5) are representative of compounds of formula (I). Scheme 5

hydrolysis 1) base

2) LG^CrCgalkyl or LG^CpCgalkylenyl-G ydrolysis or C _r C ₆ alkylenyl-G ^£ or C _r C ₆ alkylenyl-G ^B

(5-4)

[00408] As shown in Scheme 5, compounds of formula (5-3) and formula (5-4) can be prepared from compounds of formula (5-1). Compounds of formula (5-1) can be prepared as described in Schemes 1 or 2. Compounds of formula (5-1) can be reacted with a base such as lithium

diisopropylamide or lithium bis(trimethylsilyl)amide at -78 °C in a solvent such as tetrahydrofuran and then treated with LG'-Q-Ceaikyl or LG'-Q-Cealkylenyl-G ¹¹ ; wherein LG ¹ is a leaving group such as chlorine, bromine, iodine or a sulfonate; with warming to ambient temperature to give compounds of formula (5-2). Compounds of formula (5-2) can be hydrolyzed to the corresponding carboxylic acid of formula (5-3) using a base such as aqueous lithium hydroxide in a solvent such as

tetrahydrofuran at ambient temperature or heated in a solvent such as dioxane. Additionally, compounds of formula (5-2) can be deprotonated and alkylated with LG'-Ci-Cealkyl or LG'-Q- C ₆ alkylenyl-G ^B as previously described to give an alpha, alpha-dialkylated ester. The ester can be hydrolyzed using the conditions previously described to give compounds of formula (5-4).

Compounds of formula (5-3) and formula (5-4) are representative of compounds of formula (I).

cheme 6

or C _j -Cgalkylenyl-G

or LG'-q-Cgalkyli

chiral auxiliary removal or q-Cgalkylenyl-G ¹

[00409] Compounds of formula (6-1) can be converted to chiral compounds of formula (6-3) using a sequence similar to that described in Scheme 5. Compounds of formula (6-1) can be reacted with a chiral auxiliary (Xc) such as the Evans' oxazolidinones. To this end, compounds of formula (6-1) can be converted to an anhydride by treatment with pivaloyl chloride in the presence of triethylamine. The anhydride can be reacted with the lithium salt of a chiral oxazolidinones. This intermediate imide can then be alkylated as described in Scheme 5 to give chiral compounds of formula (6-2). Removal of the chiral auxiliary gives compounds of formula (6-3). In the case of the oxazolidinones chiral auxiliaries, this can be accomplished with lithium hydroperoxide in a mixture of water and

tetrahydrofuran. Compounds of formula (6-3) are representative of compounds of formula (I).

Scheme 7

(7-4)

[00410] As shown in Scheme 7, compounds of formula (7-1) can be converted to compounds of formula (7-4). Accordingly, compounds of formula (7-1), wherein R ^{7 1} is either hydrogen or an alkyl group, can be reacted with acetyl chloride and sodium iodide at ambient temperature in a solvent such as acetonitrile over 6 to 30 hours to give a compound of formula (7-2). Compounds of formula (7-2) can be reacted with amines of formula (1-2) in optionally heated acetonitrile to give compounds of formula (7-3). Compounds of formula (7-3) can then be coupled with carboxylic acids of formula (1- 4) or the corresponding acid chlorides and hydrolyzed as described in Schemes 1 and 2 to give compounds of formula (7-4). Compounds of formula (7-4) are representative of compounds of formula (I).

Scheme 8

amide coupling

G , 0-(CR ⁹ R ¹⁰ ), 2-C0 ₂ H

L ¹

[00411] As shown in Scheme 8, compounds of formula (1-2) can be transformed to compounds of formula (8-2). Amines of formula (1-2) can be alkylated with (2-bromoethoxy)(teri- butyl)dimethylsilane in optionally heated acetonitrile. The amine thus obtained can be protected by treatment with di-teri-butyl dicarbonate. Then the silyl ether can be cleaved by treatment with tetrabutylammonium fluoride in a solvent such as tetrahydrofuran to reveal the primary hydroxyl group. The teri-butoxycarbonyl protecting group can be removed by acidic treatment with trifluoroacetic acid in dichloromethane or hydrochloric acid in dioxane to expose the amine. The amine can then be coupled with carboxylic acids of formula (1-4) using the amide coupling conditions described in Schemes 1 and 2 or the alternative acid chloride methodology also described in Schemes 1 and 2 to give compounds of formula (8-1). Compounds of formula (8-1) can treated with a base such as potassium teri-butoxide in an optionally heated solvent such as tetrahydrofuran and then alkylated with LG ¹ -(CR ⁹ R ¹⁰ ) _{1 2} -CO ₂ C ₁ -C ₂ alkyl; wherein LG ¹ is a leaving group such as chlorine, bromine, iodine or a sulfonate. The intermediate ester can be hydrolyzed using the conditions described in Scheme 4 to give compounds of formula (8-2). Ethers of formula (8-2) are representative of compounds of formula (I). Scheme 9

3) Br-C(R ⁹ R ^{l 0} ) ₁ . ₂ -CO ₂ C ₁ -C ₂ alkyl

4) hydrolysis

[00412] As shown in Scheme 9, compounds of formula (8-1) can be converted to thioethers of formula (9-1) by two different sequences. In the first option, compounds of formula (8-1) can first be reacted with methanesulfonyl chloride in the presence of a tertiary amine base in dichloromethane. The intermediate sulfonate can then be displaced by reaction with HS-C(R ⁹ R ¹⁰ ) ₁ _ ₂ -CO ₂ C ₁ -C ₂ alkyl in a mixture of a solvent such as dimethyl sulfoxide and acetone in the presence of a base such as potassium carbonate. Lastly, the ester can be hydrolyzed to the corresponding carboxylic acid using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature or heated in a solvent such as dioxane to give compounds of formula (9-1).

[00413] Alternatively, compounds of formula (8-1) can be reacted with methanesulfonyl chloride in the presence of a tertiary amine base in dichloromethane. The intermediate sulfonate can then be displaced by reaction with potassium ethanethioate in optionally heated N,N-dimethylformamide. Then the intermediate ethanethioate can be reacted with Br-C(R ⁹ R ¹⁰ )i_ ₂ -CO ₂ Ci-C ₂ alkyl in the presence of a base such as potassium hydroxide in a solvent such as optionally heated methanol. Lastly, the ester thus formed can be hydrolyzed to the corresponding carboxylic acid using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature or heated in a solvent such as dioxane to give compounds of formula (9-1). Compounds of formula (9-1) are representative of compounds of formula (I).

Scheme 10

[00414] As shown in Scheme 10, phosphonic acids of formula (10-1) can be prepared from the primary alcohols of formula (8-1). Compounds of formula (8-1) can be alkylated with LG ¹ -C(R ⁹ R ¹⁰ ) _{1 2} -P(O)(O-C ₁ -C ₂ alkyl) ₂ ; wherein LG ¹ is a leaving group such as chlorine, bromine, iodine or a sulfonate; in a solvent such as tetrahydrofuran and the presence of a base such as sodium hydride. Conversion of the intermediate phosphonate to the corresponding phosphonic acids of formula (10-1) is achieved by treatment with bromotrimethylsilane in a solvent such as

dichloromethane. Compounds of formula (10-1) are representative of compounds of formula (I).

Scheme 11

[00415] As shown in Scheme 11 , carboxylic acids of formula (11-1) can be prepared from the primary alcohols of formula (8-1). Compounds of formula (8-1) can be reacted methyl acrylate in the presence of a base such as sodium hydride in a solvent such as tetrahydrofuran. The Michael reaction adducts can then be hydrolyzed using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature or heated in a solvent such as dioxane to give compounds of formula (11-1). Compounds of formula (11-1) are representative of compounds of formula (I).

Scheme 12

1) BrCH ₂ CH ₂ Br, base (CR R ^u ) _1-2 -C0 ₂ C _! -C ₂ alkyl

HS(CR ⁹ R ¹⁰ ) ₁ _ ₂ CO2C ₁ -C ₂ alkyl - ^W

2

2) G ² -L ² -NH ₂ ( l -2) G2 ^L

- 1 )

O amide coupling

Gl _Ll L _N ^ ^S— (CR ⁹ R ¹⁰ ),_ ₂ -CO ₂ H 2) hydrolysis

G ^{2 L2} (9-1)

[00416] As shown in Scheme 12, mercapto esters, HS-C(R ⁹ R ¹⁰ )i_ ₂ -CO ₂ Ci-C ₂ alkyl, can be converted to compounds of formula (9-1) using an alternative sequence. Accordingly, mercapto esters,

can be alkylated with 1,2-dibromoethane in the presence of a base such as potassium carbonate in a heated solvent such as acetonitrile. The intermediate bromide can then be reacted with amines of formula (1-2) in heated acetonitrile to give compounds of formula (12-1). Compounds of formula (12-1) can be coupled with compounds of formula (1-4) using a reagent such as ( 1 - [bis(dimethylamino)methylene] - 1 H- 1 ,2,3 -triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (HATU) in the presence of a tertiary amine base in a solvent such as N,N-dimethylformamide at ambient temperature over 1 to 24 hours. Alternatively, carboxylic acids of formula (1-4) can be converted to the corresponding acid chlorides as described in Schemes 1 and 2, and then the resultant acid chloride can be reacted with amines of formula (12-1) to give the corresponding amides. Then, the ester can be hydrolyzed to the corresponding carboxylic acid using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature or heated in a solvent such as dioxane to give compounds of formula (9-1). Compounds of formula (9-1) are representative of compounds of formula (I).

Scheme 13

2) hydrolysis (8-2)

[00417] As shown in Scheme 13, compounds of formula (13-1) can be transformed to compounds of formula (8-2) in the illustrated alternative sequence. Accordingly, compounds of formula (13-1) can be alkylated with 2-bromo-l,l-dimethoxyethane in the presence of sodium hydride in a solvent such as N,N-dimethylformamide. The resultant acetals can be transformed to the corresponding aldehydes, compounds of formula (13-2), by treatment with aqueous acid. Aldehydes of formula (13- 2) can be reductively aminated with G ² -L ² -NH ₂ under a hydrogen atmosphere in the presence of palladium on carbon in a solvent such 1 ,2-dichloroethane to give compounds of formula (13-3). Compounds of formula (13-3) can be coupled with compounds of formula (1-4) using a reagent such as (l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]py ridinium 3-oxid hexafluorophosphate (HATU) in the presence of a tertiary amine base in a solvent such as N,N-dimethylformamide at ambient temperature over 1 to 24 hours. Alternatively, carboxylic acids of formula (1-4) can be converted to the corresponding acid chlorides as described in Schemes 1 and 2, and then the resultant acid chloride can be reacted with amines of formula (13-3) to give the corresponding amides. Then, the ester can be hydrolyzed to the corresponding carboxylic acid using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature or heated in a solvent such as dioxane to give compounds of formula (8-2). Compounds of formula (8-2) are representative of compounds of formula (I). Scheme 14

s as shown in Scheme 5

3) Br-TMS

[00418] As shown in Scheme 14, compounds of formula (14-3) and formula (14-4) can be prepared from compounds of formula (14-1) in a sequence similar to that described for the corresponding carboxylic acids in Scheme 2. Compounds of formula (14-1); wherein LG ¹ is chlorine, bromine, iodine or a sulfonate; can be reacted with an amine of formula (1-2) heated in a solvent such as acetonitrile or tetrahydrofuran in the presence of a tertiary amine for 0.25-24 hours to give compounds of formula (14-2). Compounds of formula (14-2) can then be reacted in a three-step process to give compounds of formula (14-3) and formula (14-4). First, the amines of formula (14-2) can be coupled with a carboxylic acids of formula (1-4) using a reagent such as (1- [bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (HATU) in the presence of a tertiary amine base in a solvent such as N,N-dimethylformamide at ambient temperature over 1 to 24 hours. Alternatively, carboxylic acids of formula (1-4) can be converted to the corresponding acid chlorides as described in Schemes 1 and 2, and then the resultant acid chloride can be reacted with amines of formula (14-2) to give the corresponding amides. The intermediate phosphanates can then optionally be alkylated on the alpha carbon using the conditions shown in Scheme 5. Then, the phosphonate can be converted to a mixture of the corresponding phosphonic acid of formula (14-3) and monophosphonate of formula (14-4) using

bromotrimethylsilane in a solvent such as dichloromethane at ambient. Compounds of formula (14-3) and formula (14-4) are representative of compounds of formula (I). Scheme 15

[00419] As shown in Scheme 15, compounds of formula (15-1) can be converted to compounds of formula (15-4), formula (15-5) and formula (15-6). Ethyl 4-hydroxyprolinate can be reacted first with tert-butyldimethylsilyl chloride in the presence of imidazole in dichloromethane, and then the intermediate silyl ether can be reacted with G ² -L ² -LG ¹ ; wherein LG ¹ is chlorine, bromine, iodine or a sulfonate; in heated acetonitrile to give compounds of formula (15-2). Compounds of formula (15-2) can be reacted with samarium iodide in hexamethylphosphoramide and tetrahydrofuran in the presence of air and pivalic acid. Subsequent amide bond formation by coupling with a carboxylic acids of formula (1-4) using a reagent such as (l-[bis(dimethylamino)methylene]-lH-l ,2,3- triazolo[4,5- ?]pyridinium 3-oxid hexafluorophosphate (HATU) in the presence of a tertiary amine base in a solvent such as N,N-dimethylformamide at ambient temperature over 1 to 24 hours gives compounds of formula (15-3). Alternatively, carboxylic acids of formula (1-4) can be converted to the corresponding acid chlorides as described in Schemes 1 and 2, and then the resultant acid chloride can be reacted with amines derived from compounds of formula (15-2) to give the corresponding amides. Compounds of formula (15-3) can be treated with tetra-«-butylammonium fluoride in tetrahydrofuran for about 1 hour to remove the silyl protecting group. Subsequent ester hydrolysis using a base such as aqueous lithium hydroxide in a solvent such as tetrahydrofuran at ambient temperature or heated in a solvent such as dioxane to gives a separable mixture of compounds of formula (15-4) and formula (15-5). Compounds of formula (15-3) can be reacted with tetra-«- butylammonium fluoride overnight in tetrahydrofuran to give compounds of formula (15-6). Compounds of formula (15-4), formula (15-5) and formula (15-6) are representative of compounds of formula (I).

Scheme 16

[00420] As is shown in Scheme 16, compounds of formula (1-5) can be transformed to compounds of formula (16-1). Compounds of formula (1-5) can be treated with carbonyldiimidazole in heated tetrahydrofuran. Then, an N-substituted sulfuric diamide, H ₂ NS0 ₂ NHR ^G3 , can be added in the presence of a base such as l,8-diazabicyclo[5.4.0]undec-7-ene at or near ambient temperature to give compounds of formula (16-1). Compounds of formula (16-1) are representative of compounds of formula (I).

Scheme 17

[00421] As is shown in Scheme 17, compounds of formula (1-5) can be transformed to compounds of formula (17-1). Compounds of formula (1-5) can be treated with carbonyldiimidazole in heated isopropyl acetate. Then, a sulfonamide, H ₂ NS0 ₂ R ^G3 , can be added in the presence of a base such as l,8-diazabicyclo[5.4.0]undec-7-ene with continued heating to give compounds of formula (17-1). Compounds of formula (17-1) are representative of compounds of formula (I).

Scheme 18

I 9 9 O. O

P i ₍ cv _\ OVA R ^G3a S0 ₂ NC Gl I U ³ £ _c .

G. _^ (CH ₂ ) ₂ _3-OH - _L i ^λ Λο N R ^G3a

L· IN I I F

2 ₂ L ^{2 H}

_G 2 ^L (18-1) (18-2)

[00422] As is shown in Scheme 18, compounds of formula (18-1) can be transformed to compounds of formula (18-2). Compounds of formula (18-1) can be treated with a sulfonyl isocyanate, CNS0 ₂ R ^G3a , at or near ambient temperature in a solvent such as teri-butyl methyl ether to give compound of formula (18-2). Compounds of formula (18-2) are representative of compounds of formula (I). Scheme 19

(19-2)

[00423] As is shown in Scheme 19, compounds of formula (1-5) can be transformed to compounds of formula (19-2). Compounds of formula (1-5) can be converted to the corresponding nitrile in a two-step process. Compounds of formula (1-5) can be reacted with ammonium hydroxide and ((3H- [ 1 ,2,3]triazolo[4,5-¾]pyridin-3-yl)oxy)tri(pyrrolidin- 1 -yl)phosphonium hexafluorophosphate(V) (PyAOP) in the presence of a tertiary amine base in a solvent such as tetrahydrofuran to give the corresponding amide. The amide can then be dehydrated in the second step by treatment with trifluoroacetic anhydride in a solvent such as a mixture of dioxane and pyridine to give compounds of formula (19-1). Compounds of formula (19-1) can then be reacted with sodium azide in the presence of ammonium chloride in heated N,N-dimethylformamide to give compounds of formula (19-2). Compounds of formula (19-2) are representative of compounds of formula (I).

Scheme 20

[00424] As shown in Scheme 20, amines of formula (1-2) can be prepared from compounds of formula (20-1). Compounds of formula (20-1); wherein Hal ¹ is chlorine, bromine, or iodine; can be reacted with isoindoline-l,3-dione in the presence of sodium iodide and a base such as potassium carbonate in a solvent such as optionally heated acetonitrile to give compounds of formula (20-2). Compounds of formula (20-2) can be reacted with hydrazine or hydrazine hydrate in an optionally heated solvent such as methanol to give compounds of formula (1-2). [00425] Alternatively, compounds of formula (20-3) can be reacted first with thionyl chloride, and then the intermediate acid chloride in optionally cooled tetrahydrofuran can be reacted with ammonia to give compounds of formula (20-4). Compounds of formula (20-4) can be reduced with a reductant such as lithium aluminum hydride in optionally heated tetrahydrofuran to give compounds of formula (1-2).

[00426] Compounds of formula (1-2) can be used as described in Schemes 1, 2, 3, 4, 7, 8, 13 and 14.

[00427] The compounds and intermediates of the present disclosure may be isolated and purified by methods well-known to those skilled in the art of organic synthesis. Examples of conventional methods for isolating and purifying compounds can include, but are not limited to, chromatography on solid supports such as silica gel, alumina, or silica derivatized with alkylsilane groups, by recrystallization at high or low temperature with an optional pretreatment with activated carbon, thin- layer chromatography, distillation at various pressures, sublimation under vacuum, and trituration, as described for instance in "Vogel's Textbook of Practical Organic Chemistry", 5th edition (1989), by Furniss, Hannaford, Smith, and Tatchell, pub. Longman Scientific & Technical, Essex CM20 2JE, England.

[00428] Many of the compounds of the present disclosure have at least one basic nitrogen whereby the compound can be treated with an acid to form a desired salt. For example, a compound may be reacted with an acid at or above room temperature to provide the desired salt, which is deposited, and collected by filtration after cooling. Examples of acids suitable for the reaction include, but are not limited to tartaric acid, lactic acid, succinic acid, as well as mandelic, atrolactic, methanesulfonic, ethanesulfonic, toluenesulfonic, naphthalenesulfonic, benzenesulfonic, carbonic, fumaric, maleic, gluconic, acetic, propionic, salicylic, hydrochloric, hydrobromic, phosphoric, sulfuric, citric, hydroxybutyric, camphor sulfonic, malic, phenylacetic, aspartic, or glutamic acid, and the like.

[00429] Optimum reaction conditions and reaction times for each individual step can vary depending on the particular reactants employed and substituents present in the reactants used. Unless otherwise specified, solvents, temperatures and other reaction conditions can be readily selected by one of ordinary skill in the art. Specific procedures are provided in the Examples section. Reactions can be worked up in the conventional manner, e.g. by eliminating the solvent from the residue and further purified according to methodologies generally known in the art such as, but not limited to, crystallization, distillation, extraction, trituration and chromatography. Unless otherwise described, the starting materials and reagents are either commercially available or can be prepared by one skilled in the art from commercially available materials using methods described in the chemical literature.

[00430] Routine experimentations, including appropriate manipulation of the reaction conditions, reagents and sequence of the synthetic route, protection of any chemical functionality that cannot be compatible with the reaction conditions, and deprotection at a suitable point in the reaction sequence of the method are included in the scope of the present disclosure. Suitable protecting groups and the methods for protecting and deprotecting different substituents using such suitable protecting groups are well known to those skilled in the art; examples of which can be found in PGM Wuts and TW Greene, in Greene's book titled Protective Groups in Organic Synthesis (4 ^th ed.), John Wiley & Sons, NY (2006), which is incorporated herein by reference in its entirety. Synthesis of the compounds of the present disclosure can be accomplished by methods analogous to those described in the synthetic schemes described hereinabove and in specific examples.

[00431] Starting materials, if not commercially available, can be prepared by procedures selected from standard organic chemical techniques, techniques that are analogous to the synthesis of known, structurally similar compounds, or techniques that are analogous to the above described schemes or the procedures described in the synthetic examples section.

[00432] When an optically active form of a compound of the present disclosure is required, it can be obtained by carrying out one of the procedures described herein using an optically active starting material (prepared, for example, by asymmetric induction of a suitable reaction step), or by resolution of a mixture of the stereoisomers of the compound or intermediates using a standard procedure (such as chromatographic separation, recrystallization or enzymatic resolution).

[00433] Similarly, when a pure geometric isomer of a compound of the present disclosure is required, it can be obtained by carrying out one of the above procedures using a pure geometric isomer as a starting material, or by resolution of a mixture of the geometric isomers of the compound or intermediates using a standard procedure such as chromatographic separation.

[00434] It can be appreciated that the synthetic schemes and specific examples as illustrated in the Examples section are illustrative and are not to be read as limiting the scope of the present disclosure as it is defined in the appended claims. All alternatives, modifications, and equivalents of the synthetic methods and specific examples are included within the scope of the claims.

Pharmaceutical Compositions

[00435] This disclosure also provides for pharmaceutical compositions comprising a

therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier, diluent, or excipient thereof. The phrase "pharmaceutical composition" refers to a composition suitable for administration in medical or veterinary use.

[00436] The pharmaceutical compositions that comprise a compound of formula (I), alone or in combination with a second therapeutic agent, may be administered to the subjects orally, rectally, parenterally, intracisternally, intravaginally, intraperitoneally, topically (as by powders, ointments or drops), bucally or as an oral or nasal spray. The term "parenterally" as used herein, refers to modes of administration which include intravenous, intramuscular, intraperitoneal, intrasternal, subcutaneous and intraarticular injection and infusion.

[00437] The term "pharmaceutically acceptable carrier" as used herein, means a non-toxic, inert solid, semi-solid or liquid filler, diluent, encapsulating material or formulation auxiliary of any type. Some examples of materials which may serve as pharmaceutically acceptable carriers are sugars such as, but not limited to, lactose, glucose and sucrose; starches such as, but not limited to, corn starch and potato starch; cellulose and its derivatives such as, but not limited to, sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; excipients such as, but not limited to, cocoa butter and suppository waxes; oils such as, but not limited to, peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols; such a propylene glycol; esters such as, but not limited to, ethyl oleate and ethyl laurate; agar; buffering agents such as, but not limited to, magnesium hydroxide and aluminum hydroxide; alginic acid; pyrogen-free water; isotonic saline; Ringer's solution; ethyl alcohol, and phosphate buffer solutions, as well as other non-toxic compatible lubricants such as, but not limited to, sodium lauryl sulfate and magnesium stearate, as well as coloring agents, releasing agents, coating agents, sweetening, flavoring and perfuming agents, preservatives and antioxidants may also be present in the composition, according to the judgment of the formulator.

[00438] Pharmaceutical compositions for parenteral injection comprise pharmaceutically acceptable sterile aqueous or nonaqueous solutions, dispersions, suspensions or emulsions as well as sterile powders for reconstitution into sterile injectable solutions or dispersions just prior to use. Examples of suitable aqueous and nonaqueous carriers, diluents, solvents or vehicles include water, ethanol, polyols (such as glycerol, propylene glycol, polyethylene glycol and the like), vegetable oils (such as olive oil), injectable organic esters (such as ethyl oleate), and suitable mixtures thereof. Proper fluidity may be maintained, for example, by the use of coating materials such as lecithin, by the maintenance of the required particle size in the case of dispersions and by the use of surfactants.

[00439] These compositions may also contain adjuvants such as preservatives, wetting agents, emulsifying agents and dispersing agents. Prevention of the action of microorganisms may be ensured by the inclusion of various antibacterial and antifungal agents, for example, paraben, chlorobutanol, phenol sorbic acid, and the like. It may also be desirable to include isotonic agents such as sugars, sodium chloride, and the like. Prolonged absorption of the injectable pharmaceutical form may be brought about by the inclusion of agents which delay absorption, such as aluminum monostearate and gelatin.

[00440] In some cases, in order to prolong the effect of the drug, it is desirable to slow the absorption of the drug from subcutaneous or intramuscular injection. This may be accomplished by the use of a liquid suspension of crystalline or amorphous material with poor water solubility. The rate of absorption of the drug then depends upon its rate of dissolution which, in turn, may depend upon crystal size and crystalline form. Alternatively, delayed absorption of a parenterally- administered drug form may be accomplished by dissolving or suspending the drug in an oil vehicle.

[00441] Injectable depot forms are made by forming microencapsule matrices of the drug in biodegradable polymers such as polylactide-polyglycolide. Depending upon the ratio of drug to polymer and the nature of the particular polymer employed, the rate of drug release may be controlled. Examples of other biodegradable polymers include poly(orthoesters) and

poly( anhydrides). Depot injectable formulations are also prepared by entrapping the drug in liposomes or microemulsions which are compatible with body tissues.

[00442] The injectable formulations may be sterilized, for example, by filtration through a bacterial-retaining filter or by incorporating sterilizing agents in the form of sterile solid compositions which can be dissolved or dispersed in sterile water or other sterile injectable medium just prior to use.

[00443] Solid dosage forms for oral administration include capsules, tablets, pills, powders and granules. In certain embodiments, solid dosage forms may contain from 1% to 95% (w/w) of a compound of formula (I). In certain embodiments, the compound of formula (I) may be present in the solid dosage form in a range of from 5% to 70% (w/w). In such solid dosage forms, the active compound may be mixed with at least one inert, pharmaceutically acceptable excipient or carrier, such as sodium citrate or dicalcium phosphate and/or a) fillers or extenders such as starches, lactose, sucrose, glucose, mannitol and silicic acid; b) binders such as carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidone, sucrose and acacia; c) humectants such as glycerol; d) disintegrating agents such as agar-agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates and sodium carbonate; e) solution retarding agents such as paraffin; f) absorption accelerators such as quaternary ammonium compounds; g) wetting agents such as cetyl alcohol and glycerol monostearate; h) absorbents such as kaolin and bentonite clay and i) lubricants such as talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate and mixtures thereof. In the case of capsules, tablets and pills, the dosage form may also comprise buffering agents.

[00444] The pharmaceutical composition may be a unit dosage form. In such form the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampules. Also, the unit dosage form may be a capsule, tablet, cachet, or lozenge itself, or it may be the appropriate number of any of these in packaged form. The quantity of active component in a unit dose preparation may be varied or adjusted from 0.1 mg to 1000 mg, from 1 mg to 100 mg, or from 1% to 95% (w/w) of a unit dose, according to the particular application and the potency of the active component. The composition may, if desired, also contain other compatible therapeutic agents. [00445] The dose to be administered to a subject may be determined by the efficacy of the particular compound employed and the condition of the subject, as well as the body weight or surface area of the subject to be treated. The size of the dose also will be determined by the existence, nature, and extent of any adverse side -effects that accompany the administration of a particular compound in a particular subject. In determining the effective amount of the compound to be administered in the treatment or prophylaxis of the disorder being treated, the physician may evaluate factors such as the circulating plasma levels of the compound, compound toxicities, and/or the progression of the disease, etc.

[00446] For administration, compounds may be administered at a rate determined by factors that may include, but are not limited to, the LD ₅₀ of the compound, the pharmacokinetic profile of the compound, contraindicated drugs, and the side-effects of the compound at various concentrations, as applied to the mass and overall health of the subject. Administration may be accomplished via single or divided doses.

[00447] The compounds utilized in the pharmaceutical method of the present disclosure may be administered, for example, at the initial dosage of about 0.001 mg/kg to about 100 mg/kg daily. In certain embodiments, the daily dose range is from about 0.1 mg/kg to about 10 mg/kg. The dosages, however, may be varied depending upon the requirements of the subject, the severity of the condition being treated, and the compound being employed. Determination of the proper dosage for a particular situation is within the skill of the practitioner. Treatment may be initiated with smaller dosages, which are less than the optimum dose of the compound. Thereafter, the dosage is increased by small increments until the optimum effect under circumstances is reached. For convenience, the total daily dosage may be divided and administered in portions during the day, if desired.

[00448] Solid compositions of a similar type may also be employed as fillers in soft and hard-filled gelatin capsules using such carriers as lactose or milk sugar as well as high molecular weight polyethylene glycols and the like.

[00449] The solid dosage forms of tablets, dragees, capsules, pills and granules can be prepared with coatings and shells such as enteric coatings and other coatings well-known in the pharmaceutical formulating art. They may optionally contain opacifying agents and may also be of a composition such that they release the active ingredient(s) only, or preferentially, in a certain part of the intestinal tract, optionally, in a delayed manner. Examples of embedding compositions which can be used include polymeric substances and waxes.

[00450] The active compounds may also be in micro-encapsulated form, if appropriate, with one or more of the above-mentioned carriers.

[00451] Liquid dosage forms for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups and elixirs. In addition to the active compounds, the liquid dosage forms may contain inert diluents commonly used in the art such as, for example, water or other solvents, solubilizing agents and emulsifiers such as ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylene glycol, dimethyl formamide, oils (in particular, cottonseed, groundnut, corn, germ, olive, castor and sesame oils), glycerol, tetrahydrofurfuryl alcohol, polyethylene glycols, and fatty acid esters of sorbitan and mixtures thereof.

[00452] Besides inert diluents, the oral compositions may also include adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring and perfuming agents.

[00453] Suspensions, in addition to the active compounds, may contain suspending agents as, for example, ethoxylated isostearyl alcohols, polyoxyethylene sorbitol and sorbitan esters,

microcrystalline cellulose, aluminum metahydroxide, bentonite, agar-agar, tragacanth and mixtures thereof.

[00454] Compositions for rectal or vaginal administration are preferably suppositories which may be prepared by mixing the compounds with suitable non-irritating carriers or carriers such as cocoa butter, polyethylene glycol, or a suppository wax which are solid at room temperature but liquid at body temperature and therefore melt in the rectum or vaginal cavity and release the active compound.

[00455] Compounds may also be administered in the form of liposomes. Liposomes generally may be derived from phospholipids or other lipid substances. Liposomes are formed by mono- or multilamellar hydrated liquid crystals which are dispersed in an aqueous medium. Any non-toxic, physiologically acceptable and metabolizable lipid capable of forming liposomes may be used. The present compositions in liposome form may contain, in addition to a compound of the present disclosure, stabilizers, preservatives, excipients, and the like. Examples of lipids include, but are not limited to, natural and synthetic phospholipids, and phosphatidyl cholines (lecithins), used separately or together.

[00456] Methods to form liposomes have been described, see example, Prescott, Ed., Methods in Cell Biology, Volume XIV, Academic Press, New York, N.Y. (1976), p. 33 et seq.

[00457] Dosage forms for topical administration of a compound described herein include powders, sprays, ointments, and inhalants. The active compound may be mixed under sterile conditions with a pharmaceutically acceptable carrier and any needed preservatives, buffers or propellants which may be required. Ophthalmic formulations, eye ointments, powders and solutions are also contemplated as being within the scope of this disclosure.

Methods of Use

[00458] The compounds and compositions using any amount and any route of administration may be administered to a subject for the treatment or prevention of liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease by secretory dysfunction and fibrosis. [00459] The term "administering" refers to the method of contacting a compound with a subject. Thus, the compounds may be administered by injection, that is, intravenously, intramuscularly, intracutaneously, subcutaneously, intraduodenally, parentally, or intraperitoneally. Also, the compounds described herein may be administered by inhalation, for example, intranasally.

Additionally, the compounds may be administered transdermally, topically, via implantation, transdermally, topically, and via implantation. In certain embodiments, the compounds and compositions thereof may be delivered orally. The compounds may also be delivered rectally, bucally, intravaginally, ocularly, or by insufflation. Lysophosphatidic acid receptor 1 (LPAR1) modulated disorders and conditions may be treated prophylactically, acutely, and chronically using compounds and compositions thereof, depending on the nature of the disorder or condition.

Typically, the host or subject in each of these methods is human, although other mammals may also benefit from the administration of compounds and compositions thereof as set forth hereinabove.

[00460] Compounds of the present disclosure are useful as modulators of LPAR1. Thus, the compounds and compositions are particularly useful for treating or lessening the severity or progression of a disease, disorder, or a condition where the lysophosphatidic acid receptor 1 is involved. Accordingly, the present disclosure provides a method for treating of liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease by secretory dysfunction or fibrosis in a subject, wherein the method comprises the step of administering to said subject a therapeutically effective amount of a compound of formula (I) or a preferred embodiment thereof as set forth above, with or without a pharmaceutically acceptable carrier.

[00461] A compound according to formula (I) or a pharmaceutically acceptable salt thereof for use in medicine.

[00462] A compound according to formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease by secretory dysfunction or fibrosis.

[00463] The use of a compound according to formula (I) or a pharmaceutically acceptable salt thereof in the preparation of a medicament.

[00464] The use of a compound according to formula (I) in the preparation of a medicament for use in the treatment of liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease by secretory dysfunction or fibrosis.

[00465] The present compounds may be co-administered to a subject. The term "co-administered" means the administration of two or more different therapeutic agents that are administered to a subject by combination in the same pharmaceutical composition or separate pharmaceutical compositions. Thus co-administration involves administration at the same time of a single pharmaceutical composition comprising two or more therapeutic agents or administration of two or more different compositions to the same subject at the same or different times.

[00466] In some embodiments, the methods comprise combination therapy, wherein the compound(s) and/or salt(s) of the present disclosure is/are co-administered with a second (or even a third, fourth, etc.) compound, such as, for example, another therapeutic agent used to treat liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease,

inflammation/immune system disease, disease of secretory dysfunction, and fibrosis. The compound(s) and/or salt(s) of this present disclosure can also be co-administered with therapeutic agents other than therapeutic agents used to treat liver, kidney, skin, heart and lung disease, cancer- associated disease, proliferative disease, inflammation/immune system disease, disease of secretory dysfunction, and fibrosis. In these co-administration embodiments, the compound(s) and/or salt(s) of the present disclosure and the second, (third, fourth, fifth, etc.) therapeutic agent(s) may be administered, for example, in a substantially simultaneous manner (e.g., or within about five minutes of each other), in a sequential manner, or both. It is contemplated that such combination therapies may include administering one therapeutic agent multiple times between the administrations of the other. The time period between the administration of each agent may range from a few seconds (or less) to several hours or days, and will depend on, for example, the properties of each composition and active ingredient (e.g., potency, solubility, bioavailability, half-life, and kinetic profile), as well as the condition of the patient. The compound(s) and/or salt(s) of this disclosure and the second, (third, fourth, fifth, etc.) therapeutic agent may also be administered in a single formulation.

[00467] In certain embodiments, the method comprises co-administering to the subject the compound(s) and/or salt(s) of the present disclosure with one or more compounds selected from the group consisting of corticosteroids, immunosuppresant, analgesics, anti-cancer agent, antiinflammatories, chemokine receptor antagonists, bronchodilators, leukotriene receptor antagonists, leukotriene formation inhibitors, monoacylglycerol kinase inhibitors, phospholipase Al inhibitors, phospholipase A2 inhibitors, and lysophospholipase D (lysoPLD) inhibitors, autotaxin inhibitors, decongestants, antihistamines, mucolytics, anticholinergics, antitussives, expectorants, and β-2 agonists.

[00468] This disclosure also is directed to kits that comprise one or more compounds and/or salts of the present disclosure, and, optionally, one or more additional therapeutic agents.

[00469] This disclosure also is directed to methods of use of the compounds, salts, compositions, and/or kits of the present disclosure to, for example, modulate the lysophosphatidic acid receptor 1 , and treat a disease treatable by modulating the lysophosphatidic acid receptor 1 (including liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease,

inflammation/immune system disease, disease by secretory dysfunction or fibrosis). [00470] This disclosure also is directed to a use of one or more compounds and/or salts of the present disclosure in the preparation of a medicament. The medicament optionally can comprise one or more additional therapeutic agents. In some embodiments, the medicament is useful for treating liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease by secretory dysfunction or fibrosis.

[00471] This disclosure also is directed to a use of one or more compounds and/or salts of the present disclosure in the manufacture of a medicament for the treatment of liver, kidney, skin, heart and lung disease, cancer-associated disease, proliferative disease, inflammation/immune system disease, disease by secretory dysfunction, pain or fibrosis. The medicament optionally can comprise one or more additional therapeutic agents.

[00472] Further benefits of Applicants' disclosure will be apparent to one skilled in the art from reading this patent application.

[00473] The following Examples may be used for illustrative purposes and should not be deemed to narrow the scope of the present disclosure.

EXAMPLES

General

[00474] Chemicals were purchased from commercial suppliers. NMR spectra were recorded on a Bruker AVANCE™ III 400 instrument. LC-MS measurements were run on Agilent 1260

HPLC/6120B MS System using the method described below. Final products were purified by preparative HPLC: Waters 2489 UV/Vis Detector and Waters 2545 Binary Gradient Pump; RT = retention time in minutes; using the methods described below.

[00475] LC-MS Methods: LC-MS analyses were performed with the following methods.

Mobile phase, solution A: water (0.1% CF ₃ C0 ₂ H); solution B: CH ₃ CN

Gradient: 5% B increase to 95% B within 1.5 minutes, 95% B for 2.3 minutes, back to 5% B within 0.1 minute and run for another 0.6 minute.

Flow Rate: 1.2 mL/minute.

Column: Phenomenex® Kinetex® CI 8, 2.6 μιη, 3.0x30 mm. 100A

Column Temperature: 40 °C

Agilent 1100/1200 HPLC system running Xcalibur 2.0.7, Open-Access 1.4, and custom login software. The mass spectrometer was operated under positive APCI or ESI ionization conditions dependent on the system used. The HPLC system comprised an Agilent Binary pump, degasser, column compartment, autosampler and diode-array detector, with a Polymer Labs ELS-2100 evaporative light-scattering detector. The column used was a Phenomenex® Kinetex® C8, 2.6 μπι 100A (2.1 mm x 30 mm), at a temperature of 65 °C. [00476] "TFA method": A gradient of 5-100% acetonitrile (A) and 0.1% trifluoroacetic acid in water (B) was used, at a flow rate of 1.5 mL/minute (0-0.05 minutes 5% A, 0.05-1.2 minutes 5-100% A, 1.2-1.4 minutes 100% A, 1.4-1.5 minutes 100-5% A. 0.25 minutes post-run delay).

[00477] "Ammonium acetate method": A gradient of 5-100% acetonitrile (A) and 10 mM ammonium acetate in water (B) was used, at a flow rate of 1.5 mL/minute (0-0.05 minutes 5% A,

0.05-1.2 minutes 5-100% A, 1.2-1.4 minutes 100% A, 1.4-1.5 minutes 100-5% A. 0.25 minutes post- run delay).

[00478] "TFA long with integration method": A gradient of 5-100% acetonitrile (A) and 0.1% trifluoroacetic acid in water (B) was used, at a flow rate of 1.5 mL/minute (0-0.1 minute 5% A, 0.1- 5.2 minutes 5-100% A, 5.2-5.7 minutes 100% A, 5.7-6.0 minutes 100-5% A. 0.25 minutes post-run delay).

[00479] Analytical chiral HPLC method

[00480] Analytical supercritical fluid chromatography (SFC) was performed on an Agilent 1260 Infinity system utilizing an Agilent 1100 HPLC stack running under Agilent OpenLab software control. The SFC system included a 6-way column switcher, C0 ₂ pump, modifier pump, oven, UV detector, and backpressure regulator. The analytical method set the oven temperature to 35 °C, the outlet pressure to 150 bar, and UV detection to 220 nm and 254 nm. The mobile phase was comprised of supercritical C0 ₂ supplied by a beverage-grade C0 ₂ cylinder modified with isopropanol. The mobile phase was held isocratically at 15% isopropanol in C0 ₂ over 5 minutes at a flow rate of 3 mL/minute. The instrument was fitted with a Chiralpak® AD-H column with dimensions of 4.6 mm

1. d. x 150 mm length with 5 μπι particles.

[00481] Preparative HPLC Method: HPLC purifications were completed using the following methods.

Mobile phase, solution A: water (0.1% CF ₃ C0 ₂ H or 0.02% NH ₄ OH); solution B: CH ₃ CN

Gradient: 30% B increase to 95% B within 10.5 minutes, 95% B for 3 minutes, back to 30% B within 0.1 minute and run for another 1.5 minutes.

Flow Rate: 15 mL/minute.

Column: Waters® Xbridge®, Prep C18, 5.0 μπι OBD, 19x150 mm

Column Temperature: 23 °C

APS Waters Prep-HPLC Purification, small scale (10 mg-300 mg):

Samples were purified by preparative HPLC on a Phenomenex® Luna® C8(2) 5 μπι 100A AXIA™ column (30 mm x 75 mm). [00482] "TFA method": A gradient of acetonitrile (A) and 0.1% trifluoroacetic acid in water (B) was used, at a flow rate of 50 mL/minute (0-1.0 minute 5% A, 1.0-8.5 minutes linear gradient 5-100% A, 8.5-11.5 minutes 100% A, 11.5-12.0 minutes linear gradient 95-5% A).

[00483] "Ammonium acetate method": A gradient of acetonitrile (A) and 10 mM ammonium acetate in water (B) was used, at a flow rate of 50 mL/minute (0-1.0 minute 5% A, 1.0-8.5 minutes linear gradient 5-100% A, 8.5-11.5 minutes 100% A, 11.5-12.0 minutes linear gradient 95-5% A).

[00484] Samples were injected in 1.5 mL dimethyl sulfoxide methanol (1 : 1). A custom purification system was used, consisting of the following modules: Waters LC4000 preparative pump; Waters 996 diode-array detector; Waters 717+ autosampler; Waters SAT/IN module, Alltech Varex III evaporative light-scattering detector; Gilson 506C interface box; and two Gilson FC204 fraction collectors. The system was controlled using Waters Millennium32 software, automated using an in-house developed Visual Basic application for fraction collector control and fraction tracking. Fractions were collected based upon UV signal threshold and selected fractions subsequently analyzed by flow injection analysis mass spectrometry using positive APCI ionization on a Finnigan Navigator using 70:30 CH ₃ OH: 10 mM NH ₄ OH(aqueous) at a flow rate of 0.8 mL/minute. Loop- injection mass spectra were acquired using a Finnigan Navigator running Navigator 1.8 software and a Gilson 215 liquid handler for fraction injection controlled by an in-house developed Visual Basic application.

[00485] Abbreviations: APCI for atmospheric pressure chemical ionization; atm for atmospheres; DCI for desorption chemical ionization; DMSO for dimethyl sulfoxide; ESI for electrospray ionization; HATU for N-[(dimethylamino)-lH-l,2,3-triazolo-[4,5-¾]pyridin-l-ylmet hylene]-N- methylmethanaminium hexafluorophosphate N-oxide or (l-[bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5- ?]pyridinium 3-oxid hexafluorophosphate; ΗΜΡΑ for hexamethylphosphoramide; HPLC for high performance liquid chromatography; LC-MS for liquid chromatography-mass spectrometry; NMR for nuclear magnetic resonance; Pd ₂ (dba) ₃ for tris(dibenzylideneacetone)dipalladium(0); RT for retention time; and TLC for thin layer chromatography

Example 1

2- { [N-(3 ,5 -dimethoxy-4-methylbenzoyl)-N-(3 -phenylpropyl)glycyl] amino } -2,3 -dihydro- 1 H-indene-2- carboxylic acid

[00486] Step 1 : ethyl 2-(2-chloroacetamido)-2,3-dihydro-lH-indene-2-carboxylate

[00487] To a solution of ethyl 2-amino-2,3 -dihydro- lH-indene-2-carboxylate (500 mg, 2.44 mmol) and diisopropylethylamine (0.851 mL, 4.87 mmol) in CH ₂ C1 ₂ (20 mL) was added a solution of 2- chloroacetyl chloride (275 mg, 2.44 mmol) in CH ₂ C1 ₂ (5 mL) dropwise at 0 °C. Then the resulting mixture was stirred at room temperature for 30 minutes. A saturated aqueous ammonium chloride solution was added to the reaction mixture followed by extraction with CH ₂ C1 ₂ (10 mLx2). The combined organic fractions were washed with brine, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-50%) to give the titled compound. LC-MS (ESI+) m/z 282.2 (M+H) ⁺ , RT = 1.751 minutes.

[00488] Step 2: ethyl 2-{ [N-(3-phenylpropyl)glycyl]arnino}-2,3-dihydro-lH-indene-2-ca rboxylate

[00489] A mixture of ethyl 2-(2-chloroacetamido)-2,3-dihydro-lH-indene-2-carboxylate (70.0 mg, 0.248 mmol, Step 1), 3-phenylpropan-l -amine (33.6 mg, 0.248 mmol) and potassium carbonate (34.3 mg, 0.248 mmol) in CH ₃ CN (1.5 mL) was stirred at room temperature for 3 hours. Then the mixture was filtered, and the solids were washed with CH ₃ CN. The filtrate was used directly in the next step without further purification.

[00490] Step 3: ethyl 2-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycyl] amino}- 2,3-dihydro-lH-indene-2-carboxylate

[00491] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (48.7 mg, 0.248 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (99.0 mg, 0.260 mmol, HATU) in N,N-dimethylformamide (2 mL) was added triethylamine (0.036 mL, 0.260 mmol). The resulting solution was stirred at room temperature for 5 minutes. Then a solution of ethyl 2-{ [N-(3-phenylpropyl)glycyl]arnino}-2,3-dihydro-lH-indene-2-ca rboxylate in CH ₃ CN (2 mL) from previous step was added in one portion. The solution was stirred at room temperature overnight. The solution was diluted with water and extracted with ethyl acetate (10 mLx2). The combined organic layers were washed with brine three times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-100%) to give the titled compound. LC-MS (ESI+) m/z 559.4 (M+H) ⁺ , RT = 1.982 minutes.

[00492] Step 4: 2-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycyl] amino}-2,3- dihydro- 1 H-indene-2-carboxylic acid

[00493] Ethyl 2-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycyl] amino}-2,3- dihydro-lH-indene-2-carboxylate (39.0 mg, 0.070 mmol, Step 3) was dissolved in tetrahydrofuran (2 mL) and methanol (0.2 mL) followed by the addition of 1 Ν lithium hydroxide (1.0 mL). The reaction was stirred at room temperature for 3 hours. The mixture was concentrated, and the residue was treated with water (5 mL) followed by the addition of 1 Ν hydrochloric acid to adjust the pH to 5. Then the aqueous mixture was extracted with ethyl acetate (5 mLx2). The combined organic fractions were washed with brine and dried over anhydrous Na ₂ S0 ₄ . The mixture was concentrated, and the residue was purified by was purified by preparative HPLC to provide the titled compound. ¾ NMR (400 MHz, DMSO- ₆ ) δ ppm 12.50 (s, 1H), 8.53 (s, 1H), 7.43 - 6.86 (m, 9H), 6.55 (d, / = 54.4 Hz, 2H), 4.03 (s, 1H), 3.82 (s, 1H), 3.72 (d, / = 9.0 Hz, 6H), 3.46 (s, 2H), 3.36 (d, / = 7.6 Hz, 1H), 3.24 - 3.04 (m, 3H), 2.57 (t, / = 7.8 Hz, 1H), 2.37 (t, / = 7.6 Hz, 1H), 1.97 (d, / = 18.9 Hz, 3H), 1.81 (dd, / = 18.3, 10.7 Hz, 2H), T = 25 °C; LC-MS (ESI+) nt/z 531.4 (M+H) ⁺ , RT = 1.982 minutes.

Example 2

l-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-pheny^

acid

[00494] Step 1 : methyl N-(3-phenylpropyl)glycinate

[00495] A mixture of methyl 2-chloroacetate (400 mg, 3.69 mmol), 3-phenylpropan-l-amine (498 mg, 3.69 mmol) and potassium carbonate (611 mg, 4.42 mmol) in acetonitrile (12 mL) was stirred at 50 °C overnight. LC-MS showed 69% conversion to the titled compound. The mixture was cooled and filtered. The filtrate was used directly in the next step without further purification. LC-MS (ESI+) nt/z 208.2 (M+H) ⁺ , RT = 1.380 minutes.

[00496] Step 2: methyl N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycinat e

[00497] To a solution of 3, 5-dimethoxy-4-methylbenzoic acid (724 mg, 3.69 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (1473 mg, 3.87 mmol, HATU) in N,N-dimethylformamide (20 mL) was added triethylamine (0.540 mL, 3.87 mmol). The resulting solution was stirred at room temperature for 5 minutes. Then the methyl N-(3-phenylpropyl)glycinate filtrate from the previous step was added in one portion. The solution was stirred at room temperature for 1 hour, then diluted with water and extracted with ethyl acetate (15 mLx2). The combined organic layers were washed with brine, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by flash column chromatography on silica gel eluted with hexanes and ethyl acetate (0-60%) to give the titled compound. LC-MS (ESI+) nt/z 386.2 (M+H) ⁺ , RT = 2.036 minutes.

[00498] Step 3: N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycine

[00499] To a solution of methyl N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycinat e (640 mg, 1.660 mmol) in dioxane (4 mL) was added 1 Ν lithium hydroxide solution (4.98 mL, 9.96 mmol). The mixture was heated to 50 °C for 1.5 hours. Then the mixture was cooled down to room temperature and acidified with 1 Ν hydrochloric acid to adjust the pH to 2-3. The mixture was extracted with ethyl acetate (10 mLx3). The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound. 'H NMR (400 MHz, DMSO-<¾ δ ppm 12.77 (s, 1H), 7.26 (dt, / = 13.7, 7.3 Hz, 2H), 7.20 - 7.08 (m, 2H), 7.05 (d, / = 7.4 Hz, 1H), 6.51 (d, / = 3.0 Hz, 2H), 4.07 (s, 1H), 3.91 (s, 1H), 3.74 (d, / = 7.5 Hz, 6H), 3.43 (t, / = 7.7 Hz, 1H), 3.23 (t, / = 7.8 Hz, 1H), 2.61 (t, / = 7.9 Hz, 1H), 2.42 (t, / = 7.7 Hz, 1H), 1.98 (d, / = 10.2 Hz, 3H), 1.91 - 1.77 (m, 2H), T = 60 °C; LC-MS (ESI+) nt/z 372.2 (M+H) ⁺ , RT = 1.897 minutes.

[00500] Step 4: methyl l-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3- phenylpropyl)glycyl] amino } cyclohexane- 1 -carboxylate [00501] To a solution of N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycine (70 mg, 0.188 mmol) and l-[bis(dimethylannno)methylene]-lH-l,23-triazolo[4,5-¾]pyri dinium 3-oxid hexafluorophosphate (79 mg, 0.207 mmol, HATU) in N,N-dimethylformamide (2 mL) was added triethylamine (28.9 μL·, 0.207 mmol). The resulting solution was stirred at room temperature for 5 minutes. Then methyl 1-aminocyclohexanecarboxylate (32.6 mg, 0.207 mmol) was added in one portion. The solution was stirred at room temperature for 1 hour. The mixture was diluted with water and extracted with ethyl acetate (10 mLx3). The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue, which was purified by flash column chromatography on silica gel eluted with hexanes and ethyl acetate (0-50%) to give the titled compound. LC-MS (ESI+) m/z 511.4 (M+H) ⁺ , RT = 2.087 minutes.

[00502] Step 5: l-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3- phenylpropyl)glycyl] amino } cyclohexane- 1 -carboxylic acid

[00503] To a solution of methyl l-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3- phenylpropyl)glycyl] amino} cyclohexane- 1-carboxylate (69.0 mg, 0.135 mmol) in tetrahydrofuran (1.5 mL) was added 2 Ν lithium hydroxide (0.405 mL). The solution was heated to 50 °C for 2 hours. The solution was acidified by addition of 1 Ν hydrochloric acid to adjust the pH to 3, and the aqueous phase was then extracted with ethyl acetate (5 mLx2). The combined organic layers were washed with brine, dried, and concentrated. The residue was purified by was purified by preparative HPLC to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.73 (s, 1H), 7.20 (d, / = 28.0 Hz, 3H), 7.13 (d, / = 7.5 Hz, 2H), 6.62 (s, 2H), 3.94 (d, / = 19.3 Hz, 2H), 3.74 (s, 6H), 3.34 (s, 2H), 2.53 (d, / = 28.4 Hz, 2H), 1.99 (s, 3H), 1.94 (d, / = 13.5 Hz, 2H), 1.85 (d, / = 11.9 Hz, 2H), 1.76 - 1.61 (m, 2H), 1.48 (d, / = 11.5 Hz, 3H), 1.37 (s, 2H), 1.23 (s, 1H), T = 60 °C; LC-MS (ESI+) m/z 497.4 (M+H) ⁺ , RT = 1.955 minutes.

Example 3

1 - { [N-(3 ,5 -dimethoxy-4-methylbenzoyl)-N-(3 -phenylpropyl)glycyl] amino } cyclopropane- 1 -carboxylic acid

[00504] The titled compound was prepared according to the procedure used for the preparation of Example 2, substituting 1 -aminocyclopropanecarboxylic acid for methyl 1- aminocyclohexanecarboxylate, to provide the titled compound. 'H NMR (400 MHz, DMSO-(f ₆ ) δ ppm 12.17 (s, 1H), 8.36 (s, 1H), 7.23 (s, 3H), 7.15 (d, / = 5.5 Hz, 2H), 6.61 (s, 2H), 3.90 (d, / = 18.9 Hz, 2H), 3.74 (s, 6H), 3.34 (s, 2H), 2.66 - 2.49 (m, 2H), 1.99 (s, 3H), 1.95 - 1.72 (m, 2H), 1.32 (q, / = 4.4 Hz, 2H), 1.06 - 0.72 (m, 2H), T = 60 °C; LC-MS (ESI+) m/z 455.2 (M+H) ⁺ , RT = 1.824 minutes. Example 4

5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid

[00505] Step 1 : methyl 5-[(teri-butoxycarbonyl)(3-phenylpropyl)amino]pentanoate

[00506] A solution of methyl 5-bromopentanoate (25.0 g, 128 mmol) in acetonitrile (200 mL) was heated to reflux, and then a solution of 3-phenylpropan-l -amine (19.1 g, 141 mmol) in acetonitrile (5 mL) was added dropwise to the mixture. The mixture was heated to reflux for 0.5 hour and then cooled to 0 °C. Di-teri-butyl dicarbonate (30.8 g, 141 mmol) was added to the mixture, and triethylamine (13.0 g, 128 mmol) was subsequently added. The mixture was stirred at room temperature for 30 minutes and then concentrated to dryness. The residue was diluted with water (100 mL) and extracted with ethyl acetate (300 mLx2). The combined organic layers were dried over Na ₂ S0 ₄ , filtered and concentrated. The crude residue was purified by flash chromatography eluted with hexane and ethyl acetate (0-10%) to give the titled compound. LC-MS (ESI+) m/z 250 (M- 100+H) ⁺ , RT = 2.19 minutes.

[00507] Step 2: methyl 5-[(3-phenylpropyl)amino]pentanoate

[00508] To a solution of methyl 5-[(teri-butoxycarbonyl)(3-phenylpropyl)amino]pentanoate (9.60 g, 27.5 mmol) in dichloromethane (100 mL) was added trifluoroacetic acid (10.6 mL, 137 mmol) at room temperature. After 2 hours, the mixture was concentrated to dryness to give the titled compound as a trifluoroacetic acid salt which was used in the next step without additional purification. LC-MS (ESI+) m/z 250 (M+H) ⁺ , RT = 1.50 minutes.

[00509] Step 3: methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoate

[00510] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (5.40 g, 27.5 mmol) in N,N- dimethylformamide (60 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (10.5 g, 27.5 mmol, HATU), and the mixture was stirred at room temperature for 15 minutes. Then a mixture of methyl 5-[(3-phenylpropyl)amino]pentanoate (trifluoroacetic acid salt) (9.52 g, 27.5 mmol) and diisopropylethylamine (14.4 mL, 83.0 mmol) in N,N-dimethylformamide (5 mL) were added to the mixture. The mixture was stirred at room temperature for 2 hours. Then water was added to the mixture, and the mixture was extracted with ethyl acetate (30 mLx3). The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by flash chromatography eluting with hexane and ethyl acetate (0-40%) to give the titled compound. H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.26 - 6.96 (m, 5H), 6.49 (s, 2H), 3.81 (s, 6H), 3.66 (s, 3H), 3.38 (brs, 4H), 2.58 (brs, 2H), 2.29 (brs, 2H), 2.10 (s, 3H), 1.94 (brs, 2H), 1.61 (brs, 4H); LC-MS (ESI+) m/z 428 (M+H) ⁺ , RT = 2.11 minutes.

[00511] Step 4: 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid

[00512] To a solution of methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] pentanoate (1.03 g, 2.41 mmol) in tetrahydrofuran (10 mL) was added 1 N lithium hydroxide solution (11.7 mL). The mixture was stirred at room temperature overnight. Then the solution was concentrated, and the residue was washed with diethyl ether twice. The aqueous layer was acidified with 1 N hydrochloric acid solution to pH = 3, and extracted with ethyl acetate (30.0 mLx3). The combined organic layers were dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by preparative HPLC to give the titled compound. NMR (400 MHz, DMSO- ₆ ) 5 ppm 7.18 (dt, / = 34.8, 7.6 Hz, 5H), 6.49 (s, 2H), 3.76 (s, 6H), 3.29 (s, 4H), 2.50 (s, 2H), 2.17 (s, 2H), 2.00 (s, 3H), 1.95-1.76 (m, 2H), 1.54 (d, / = 8.7 Hz, 2H), 1.44 (s, 2H), T = 60 °C; LC- MS (ESI+) m/z 414.2 (M+H) ⁺ , RT = 1.943 minutes.

Example 5

6- [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino]hexanoic acid

[00513] Step 1 : methyl 6-((3-phenylpropyl)amino)hexanoate

[00514] A mixture of methyl 6-bromohexanoate (250 mg, 1.20 mmol), 3-phenylpropan-l -amine (162 mg, 1.20 mmol) and potassium carbonate (198 mg, 1.44 mmol) in CH ₃ CN (6 mL) was stirred at reflux for 1.5 hours. Then the mixture was cooled down to room temperature and filtered. The filtrate was used for the next step without further purification. LC-MS (ESI+) m/z 264.2 (M+H) ⁺ , RT = 1.513 minutes.

[00515] Step 2: methyl 6-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]hexa noate

[00516] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (235 mg, 1.20 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (477 mg, 1.26 mmol, HATU) in N,N-dimethylformamide (8 mL) was added triethylamine (0.175 mL, 1.26 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then the filtrate from the previous step was added in one portion. The mixture was stirred at room temperature overnight. The solution was diluted with water (30 mL) and extracted with ethyl acetate (20 mLx3). The combined organic layers were washed with brine three times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-50%) to provide the titled compound. LC-MS (ESI+) m/z 442.2 (M+H) ⁺ , RT = 2.147 minutes.

[00517] Step 3: 6-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]hexa noic acid

[00518] To a solution of methyl 6-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] hexanoate (256 mg, 0.580 mmol) in tetrahydrofuran (4 mL) was added aqueous lithium hydroxide solution (1.0 N, 3.48 mL). The mixture was stirred at room temperature for 2 hours. The mixture was acidified with 1 N hydrochloric acid solution to adjust pH = 3. Then the mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue that was purified by preparative HPLC and lyophilized to give the titled compound. ¾ NMR (400 MHz, DMSO- ₆ ) δ ppm 7.18 (dt, / = 35.1, 7.5 Hz, 5H), 6.49 (s, 2H), 3.75 (s, 6H), 3.25 (s, 4H), 2.50 (s, 2H), 2.12 (d, / = 7.6 Hz, 2H), 2.00 (s, 3H), 1.85 (t, / = 7.6 Hz, 2H), 1.59 - 1.32 (m, 4H), 1.22 (d, / = 16.3 Hz, 2H), T = 60 °C; LC-MS (ESI+) m/z 428.2 (M+H) ⁺ , RT = 1.981 minutes.

Example 6

{2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]eth oxy}acetic acid

[00519] Step 1 : teri-butyl (2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)(3-phenylpropyl)carbama te

[00520] To a solution of 3-phenylpropan-l -amine (27.1 g, 201 mmol) in acetonitrile (300 mL) was added a solution of (2-bromoethoxy)(teri-butyl)dimethylsilane (40.0 g, 167 mmol) in acetonitrile (20 mL) dropwise at 60 °C. The mixture was refluxed overnight. Then the mixture was cooled to room temperature, and di-teri-butyl dicarbonate (31.1 mL, 134 mmol) was added to the mixture followed by stirring at room temperature for 1 hour. The mixture was concentrated, and the residue was partitioned between ethyl acetate and water. The aqueous phase was further extracted with ethyl acetate (50 mLx3). The combined organic layers were dried over Na ₂ S0 ₄ , filtered and concentrated to give the crude titled compound which was used directly in the next step. LC-MS (ESI+) m/z 294.2 (M-100+H) ⁺ , RT = 2.56 minutes.

[00521] Step 2: teri-butyl (2-hydroxyethyl)(3-phenylpropyl)carbamate

[00522] To a solution of crude teri-butyl (2-{ [teri-butyl(dimethyl)silyl]oxy }ethyl)(3- phenylpropyl)carbamate (65.7 g, 167 mmol) in tetrahydrofuran (200 mL) was added

tetrabutylammonium fluoride (43.7 g, 167 mmol) at room temperature. The mixture was stirred at room temperature for 3 hours. The solution was concentrated, and the residue was diluted with ethyl acetate and water. The mixture was extracted with ethyl acetate, and the organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated in vacuo. The crude residue was purified by flash column chromatography on silica gel eluted with hexanes and ethyl acetate (0-50%) to give the titled compound. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.35 - 7.24 (m, 2H), 7.24 - 7.13 (m, 3H), 3.73 (t, / = 5.3 Hz, 2H), 3.37 (t, / = 5.3 Hz, 2H), 3.26 (t, / = 7.5 Hz, 2H), 2.69 - 2.53 (m, 2H), 2.36 (s, 1H), 1.86 (tt, / = 9.4, 6.7 Hz, 2H), 1.45 (s, 9H); LC-MS (ESI+) m/z 180.1 (M-100+H) ⁺ , RT = 2.00 minutes.

[00523] Step 3: 2-[(3-phenylpropyl)amino]ethan-l-ol

[00524] To a solution of teri-butyl (2-hydroxyethyl)(3-phenylpropyl)carbamate (1.50 g, 5.37 mmol) in 1,4-dioxane (3 mL) was added a solution of hydrochloric acid in 1,4-dioxane (4 N, 20 mL). The mixture was stirred at room temperature overnight. Then the mixture was concentrated in vacuo to give the titled compound as a hydrochloride salt which directly in the next step. LC-MS (ESI+) m/z 180 (M+H) ⁺ , RT = 0.187 minutes.

[00525] Step 4: N-(2-hydroxyethyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpropyl) benzamide

[00526] To a solution of 3, 5-dimethoxy-4-methylbenzoic acid (219 mg, 1.12 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (445 mg, 1.17 mmol, HATU) in N,N-dimethylformamide (6 mL) was added triethylamine (0.163 mL, 1.17 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then 2-[(3- phenylpropyl) amino] ethan-l-ol (200 mg, 1.12 mmol) from the previous step in CH ₃ CN (10 mL) was treated with triethylamine to adjust pH to 8-9. Then the mixture was added to the N,N- dimethylformamide solution in one portion. The resulting mixture was stirred at room temperature for 2 hours. The mixture was diluted with water (20 mL) and extracted with ethyl acetate (20 mLx2). The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (20-100%) to give the titled compound. ^J H NMR (400 MHz, DMSO- e) δ ppm 7.22 (d, / = 7.4 Hz, 2H), 7.14 (dd, / = 10.8, 3.9 Hz, 3H), 6.56 (s, 2H), 4.60 (s, 1H), 3.76 (s, 6H), 3.56 (d, / = 16.4 Hz, 2H), 3.37 (s, 4H), 2.51 (d, / = 9.0 Hz, 2H), 2.00 (s, 3H), 1.93 - 1.82 (m, 2H), T = 60 °C; LC-MS (ESI+) m/z 358.2 (M+H) ⁺ , RT = 1.886 minutes.

[00527] Step 5: methyl {2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy } acetate

[00528] To a solution of N-(2-hydroxyethyl)-3,5-dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide (2.50 g, 6.99 mmol) and methyl 2-chloroacetate (2.15 mL, 24.5 mmol) in tetrahydrofuran (60 mL) was added potassium 2-methylpropan-2-olate (2.75 g, 24.5 mmol) in one portion. Then the mixture was heated to reflux for 1 hour. Additional methyl 2-chloroacetate (2.15 mL, 24.5 mmol) and potassium 2-methylpropan-2-olate (2.75 g, 24.5 mmol) were added sequentially after the reaction was cooled down, and the resulting mixture was heated to reflux for additional 5 hours. Then the mixture was cooled down and quenched with saturated ammonium chloride solution (50 mL) and diluted with water (30 mL). This mixture was extracted with ethyl acetate (80 mLx3). The combined organic layers were washed with brine once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated in vacuo to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-50%) to give the titled compound. LC-MS (ESI+) m/z 430.2 (M+H) ⁺ , RT = 2.041 minutes.

[00529] Step 6: {2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]eth oxy}acetic acid

[00530] To a solution of methyl {2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy} acetate (1.50 g, 3.49 mmol) in tetrahydrofuran (30 mL) was added aqueous lithium hydroxide (1 N, 21.0 mL). It was heated at room temperature for 1 hour, and then the mixture was acidified with 1 N hydrochloric acid to pH = 3 while chilled in an ice -water bath. Then the mixture was extracted with ethyl acetate twice. The combined organic layers were washed with brine and dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated in vacuo to give a residue that was diluted with CH ₃ CN and purified by preparative HPLC to give the titled compound. ¾ NMR (400 MHz, DMSO-<¾ δ ppm 7.30 - 7.18 (m, 2H), 7.14 (d, J = 5.5 Hz, 3H), 6.57 (s, 2H), 3.76 (s, 6H), 3.74 (s, 2H), 3.58 (d, J = 6.3 Hz, 2H), 3.46 (s, 2H), 3.38 (s, 2H), 2.51 (d, J = 13.6 Hz, 2H), 2.00 (s, 3H), 1.87 (p, J = 7.1 Hz, 2H), T = 60 °C; LC-MS (ESI+) m/z 416.2 (M+H) ⁺ , RT = 1.897 minutes. Example 7

5 - [(3 , 5 -dimethoxybenzoyl)(3 -phenylpropyl) amino] pentanoic acid

[00531] Example 7 was prepared according to the procedure used for the preparation of Example 4, substituting 3,5-dimethoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 7.23 (d, / = 31.8 Hz, 4H), 7.05 (d, / = 5.7 Hz, IH), 6.51 (s, IH), 6.40 (s, 2H), 3.75 (s, 6H), 3.14 (s, 3H), 2.62 (s, IH), 2.23 (s, IH), 2.05 (s, IH), 1.83 (d, / = 36.0 Hz, 3H), 1.53 (m, 3H), 1.26 (d, / = 14.8 Hz, 2H); LC-MS (ESI+) m/z 400.2 (M+H) ⁺ , RT = 1.716 minutes.

Example 8

5-{ [l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3-phenylpropyl) amino}pentanoic acid

[00532] Example 8 was prepared according to the procedure used for the preparation of Example 4, substituting l-(3,5-dimethoxy-4-methylphenyl)cyclopropanecarboxylic acid for 3,5-dimethoxy-4- methylbenzoic acid, to provide the titled compound. ¾ NMR (400 MHz, DMSO- ¾) δ ppm 7.26 (t, / = 7.6 Hz, 2H), 7.19 (d, / = 7.8 Hz, 2H), 7.10 (d, / = 7.9 Hz, IH), 7.01 (dd, / = 14.0, 7.9 Hz, 2H), 6.86 (t, / = 6.4 Hz, 2H), 3.72 (s, 4H), 2.27 (d, / = 8.1 Hz, IH), 2.21 (s, IH), 2.01 (s, IH), 1.73 (s, IH), 1.42 (s, 3H), 1.35 (s, IH), 1.18 (s, 2H), 1.10 (d, / = 23.5 Hz, 3H), 0.93 (d, / = 5.2 Hz, IH); LC-MS (ESI+) m/z 410.5 (M+H) ⁺ , RT = 1.918 minutes.

Example 9

5-{ [(3,5-dimethoxyphenyl)acetyl](3-phenylpropyl)amino}pentanoic acid

[00533] Example 9 was prepared according to the procedure used for the preparation of Example 4, substituting 2-(3,5-dimethoxy-4-methylphenyl)acetic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 7.25 (td, / = 7.6, 2.8 Hz, 2H), 7.21 - 7.10 (m, 3H), 6.97 (t, / = 9.0 Hz, IH), 6.53 - 6.39 (m, 2H), 3.71 (d, / = 7.9 Hz, 5H), 3.42 (d, / = 18.1 Hz, 2H), 3.23 (q, / = 7.1, 5.2 Hz, 4H), 2.13 (dt, / = 6.8, 3.5 Hz, 2H), 1.79 - 1.67 (m, 2H), 1.51 - 1.36 (m, 4H); LC-MS (ESI+) m/z 414.5 (M+H) ⁺ , RT = 1.680 minutes.

Example 10

5-[(3-phenylpropyl)(3,4,5-trimethoxybenzoyl)amino]pentanoic acid

[00534] Example 10 was prepared according to the procedure used for the preparation of Example 4, substituting 3,4,5-trimethoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 7.22 (d, / = 7.4 Hz, 2H), 7.14 (t, / = 7.1 Hz, 3H), 6.56 (s, 2H), 3.76 (s, 6H), 3.69 (s, 3H), 3.51-3.45 (m, 4H), 2.53 (brs, 2H), 2.16 (brs, 2H), 1.96 1.77 (m, 2H), 1.53 (d, / = 7.5 Hz, 2H), 1.44 (br s, 2H); LC-MS (ESI+) m/z 430 (M+H) ⁺ , RT = 1.80 minutes. Example 11

5 - { (3 ,5 -dimethoxy-4-methylbenzoyl) [3 -(3 -methylphenyl)propyl] amino } pentanoic acid

[00535] Step 1 : methyl 5-{ [3-(3-methylphenyl)propyl]amino}pentanoate

[00536] A mixture of 3-(m-tolyl)propan-l -amine (200 mg, 1.34 mmol), methyl 5-bromopentanoate (261 mg, 1.34 mmol) and potassium carbonate (222 mg, 1.61 mmol) in CH ₃ CN (6 mL) was stirred at reflux for 3 hours. The mixture was cooled down and filtered. The filtrate was used directly in the next step without further purification. LC-MS (ESI+) m/z 264.2 (M+H) ⁺ , RT = 1.571 minutes.

[00537] Step 2: methyl 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(3- methylphenyl)propyl] amino } pentanoate

[00538] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (263 mg, 1.34 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (535 mg, 1.41 mmol, HATU) in N,N-dimethylformamide (8 mL) was added triethylamine (0.196 mL, 1.41 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then the filtrate from the previous step was added in one portion. The solution was stirred at room temperature overnight. The solution was diluted with water (20 mL) and extracted with ethyl acetate (10 mLx3). The combined organic layers were washed with brine three times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-50%) to give the titled compound. LC-MS (ESI+) m/z 442.2 (M+H) ⁺ , RT = 2.163 minutes.

[00539] Step 3: 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(3-methylphenyl)propyl] amino}pentanoic acid

[00540] To a solution of methyl 5-{ (3,5-dimethoxy-4-methylbenzoyl)[3-(3- methylphenyl)propyl] amino} pentanoate (174 mg, 0.39 mmol) in tetrahydrofuran (4 mL) was added aqueous lithium hydroxide solution (1.0 N, 2.364 mL). The mixture was stirred at room temperature for 2 hours. The mixture was then acidified with 1 N hydrochloric acid to adjust pH = 3. Then the mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue that was purified by preparative HPLC and lyophilized to give the titled compound. 'I! NMR (400 MHz, DMSO-<¾) δ ppm 7.10 (t, / = 7.3 Hz, 1H), 6.93 (t, / = 9.8 Hz, 3H), 6.49 (s, 2H), 3.76 (s, 6H), 3.28 (s, 4H), 2.48 (s, 2H), 2.24 (s, 3H), 2.17 (d, / = 6.5 Hz, 2H), 2.00 (s, 3H), 1.91 - 1.73 (m, 2H), 1.54 (q, / = 7.4 Hz, 2H), 1.44 (s, 2H), T = 60 °C; LC-MS (ESI+) m/z 428.2 (M+H) ⁺ , RT = 2.001 minutes.

Example 12

5-[(3,5-dichlorobenzoyl)(3-phenylpropyl)amino]pentanoic acid

[00541] Example 12 was prepared according to the procedure used for the preparation of Example 4, substituting 3,5-dichlorobenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 12.00 (s, 1H), 7.73 - 7.56 (m, 1H), 7.34 (dd, / = 18.6, 1.9 Hz, 2H), 7.26 (q, / = 7.3 Hz, 2H), 7.14 (dt, / = 28.8, 7.3 Hz, 2H), 7.00 (d, / = 7.3 Hz, 1H), 3.40 (d, / = 7.1 Hz, 2H), 3.10 (d, / = 7.6 Hz, 1H), 3.04 (t, / = 7.8 Hz, 1H), 2.62 (t, / = 7.9 Hz, 1H), 2.39 (t, / = 7.3 Hz, 1H), 2.24 (t, / = 6.7 Hz, 1H), 2.12 - 1.99 (m, 1H), 1.87 (t, / = 7.9 Hz, 1H), 1.75 (t, / = 7.8 Hz, 1H), 1.51 (d, / = 15.7 Hz, 2H), 1.43 (s, 1H), 1.27 (t, / = 7.6 Hz, 1H), T = 25 °C; LC-MS (ESI+) m/z 408.2 (M+H) ⁺ , RT = 2.008 minutes.

Example 13

5 - [(3 , 5 -difluoro-4-methoxybenzoyl)(3 -phenylpropyl) amino]pentanoic acid

[00542] Example 13 was prepared according to the procedure used for the preparation of Example 4, substituting 3,5-difluoro-4-methoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 11.79 (s, 1H), 7.35 - 7.00 (m, 7H), 3.95 (d, / = 1.1 Hz, 3H), 3.15 (s, 4H), 2.51 (d, / = 7.7 Hz, 2H), 2.16 (s, 2H), 1.83 (s, 2H), 1.52 (s, 2H), 1.44 (s, 2H), T = 60 °C; LC-MS (ESI+) m/z 406.2 (M+H) ⁺ , RT = 1.902 minutes.

Example 14

5-[(2-ethoxypyridine-4-carbonyl)(3-phenylpropyl)amino]pentan oic acid

[00543] Example 14 was prepared according to the procedure used for the preparation of Example 4, substituting 2-ethoxyisonicotinic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 8.23 (dd, / = 7.6 Hz, 1H), 7.33 (t, / = 7.5 Hz, 1H), 7.25 (td, / = 7.4, 6.7, 2.2 Hz, 1H), 7.20 (d, / = 6.9 Hz, 1H), 7.05 - 6.99 (m, 1H), 6.83 - 6.77 (m, 1H), 6.74 (s, 1H), 6.67 (s, 1H), 4.41 (dq, / = 9.9, 7.0 Hz, 2H), 3.53 (p, / = 6.9, 5.8 Hz, 2H), 3.17 (t, / = 7.9 Hz, 2H), 2.72 (t, / = 7.8 Hz, 1H), 2.55 - 2.38 (m, 3H), 2.26 (t, / = 6.8 Hz, 2H), 2.10 - 1.94 (m, 2H), 1.86 (p, / = 7.5 Hz, 2H), 1.71 (p, / = 3.4 Hz, 5H); LC-MS (ESI+) m/z 385.5(M+H) ⁺ , RT = 1.759 minutes.

Example 15

{ 2- [(3 , 5 -dimethoxybenzoyl) (3 -phenylpropyl)amino] ethoxy } acetic acid

[00544] Example 15 was prepared according to the procedure used for the preparation of Example 6, substituting 3,5-dimethoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 7.35 - 7.12 (m, 4H), 7.02 (d, J = 7.3 Hz, 1H), 6.48 (d, J = 1.8 Hz, 2H), 6.41 (s, 1H), 3.74 (s, 1H), 3.72 (s, 6H), 3.64 (s, 1H), 3.60 (s, 1H), 3.57 - 3.53 (m, 1H), 3.47 (d, J = 9.4 Hz, 2H), 3.32 (d, J = 6.3 Hz, 1H), 3.24 - 3.16 (m, 1H), 2.60 (t, J = 7.8 Hz, 1H), 2.38 (d, J = 6.5 Hz, 1H), 1.90 - 1.82 (m, 1H), 1.82 - 1.71 (m, 1H), T = 25 °C; LC-MS (ESI+) m/z 402.2 (M+H) ⁺ , RT = 1.813 minutes. Example 16

5 - [(3 , 5 -dichloro-4-methylbenzoyl) (3 -phenylpropyl)amino]pentanoic acid

[00545] Example 16 was prepared according to the procedure used for the preparation of Example 4, substituting 3,5-dichloro-4-methylbenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.37 (s, 1H), 7.30 - 7.23 (m, 3H), 7.12 (dt, / = 7.0 Hz, 2H), 6.98 (d, / = 7.2 Hz, 1H), 3.38 (t, / = 7.1 Hz, 2H), 3.14 (t, / = 7.6 Hz, 1H), 3.05 (t, / = 7.8 Hz, 1H), 2.61 (t, / = 7.8 Hz, 1H), 2.41 - 2.37 (m, 4H), 2.24 (t, / = 6.8 Hz, 1H), 2.08 - 2.05 (m, 1H), 1.90 - 1.85 (m, 1H), 1.78 - 1.73 (m, 1H), 1.55 - 1.54 (m, 3H), 1.28-1.26 (m, 1H); LC-MS (ESI+) m/z 422 (M+H) ⁺ , RT = 2.06 minutes.

Example 17

5-[(4-chloro-3-methoxybenzoyl)(3-phenylpropyl)amino]pentanoi c acid

[00546] Example 17 was prepared according to the procedure used for the preparation of Example 4, substituting 4-chloro-3-methoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 11.96 (s, 1H), 7.47 - 7.32 (m, 1H), 7.25 (s, 2H), 7.16 (s, 2H), 7.00 (d, J = 9.7 Hz, 2H), 6.83 (d, J = 22.3 Hz, 1H), 3.83 (d, J = 13.4 Hz, 3H), 3.39 (s, 2H), 3.12 (s, 2H), 2.67 - 2.57 (m, 1H), 2.39 (s, 1H), 2.25 (s, 1H), 2.06 (s, 1H), 1.88 (d, J = 8.0 Hz, 1H), 1.77 (s, 1H), 1.53 (s, 2H), 1.49 (s, 1H), 1.27 (s, 1H), T = 25 °C; LC-MS (ESI+) m/z 404.2 (M+H) ⁺ , RT = 1.918 minutes.

Example 18

5-[(3,5-diethoxybenzoyl)(3-phenylpropyl)amino]pentanoic acid

[00547] Example 18 was prepared according to the procedure used for the preparation of Example 4, substituting 3,5-diethoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 11.99 (s, 1H), 7.38 - 7.05 (m, 4H), 7.03 (s, 1H), 6.46 (s, 1H), 6.34 (s, 2H), 3.98 (d, / = 7.3 Hz, 4H), 3.37 (s, 2H), 3.13 (s, 2H), 2.60 (s, 1H), 2.37 (s, 1H), 2.24 (s, 1H), 2.06 (s, 1H), 1.85 (s, 1H), 1.76 (s, 1H), 1.51 (d, / = 9.5 Hz, 2H), 1.48 - 1.39 (m, 1H), 1.29 (t, / = 7.0 Hz, 6H), 1.23 (s, 1H), T = 25 °C; LC-MS (ESI+) m/z 428.2 (M+H) ⁺ , RT = 1.978 minutes.

Example 19

5-[(3,5-dimethoxy-2-nitrobenzoyl)(3-phenylpropyl)amino]penta noic acid

[00548] Example 19 was prepared according to the procedure used for the preparation of Example 4, substituting 3,5-dimethoxy-2-nitrobenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 12.06 (s, 1H), 7.32 - 7.25 (m, 1H), 7.25 - 7.19 (m, 1H), 7.19 7.09 (m, 2H), 7.05 - 7.00 (m, 1H), 6.80 (dd, / = 28.1 , 2.5 Hz, 1H), 6.48 (dd, / = 24.8, 2.4 Hz, 1H), 3.90 (d, / = 2.4 Hz, 3H), 3.85 (d, / = 12.5 Hz, 3H), 3.34 (s, 2H), 3.10 (dd, / = 14.3, 7.3 Hz, 2H), 2.62 - 2.53 (m, 1H), 2.43 (d, / = 7.3 Hz, 1H), 2.25 - 2.19 (m, 1H), 2.10 (t, / = 7.2 Hz, 1H), 1.82 (q, / = 7.7 Hz, 2H), 1.56 - 1.45 (m, 3H), 1.33 (p, / = 7.4 Hz, 1H), T = 25 °C; LC-MS (ESI+) m/z 445.2 (M+H) ⁺ , RT = 1.861 minutes.

Example 20

5-[(4-bromo-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]penta noic acid

[00549] Example 20 was prepared according to the procedure used for the preparation of Example 4, substituting 4-bromo-3,5-dimethoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 12.01 (s, 1H), 7.27 (d, / = 10.7 Hz, 2H), 7.13 (dt, / = 16.3, 7.5 Hz, 2H), 7.00 (d, / = 7.2 Hz, 1H), 6.59 (d, / = 9.1 Hz, 2H), 3.81 (d, / = 13.1 Hz, 6H), 3.39 (s, 2H), 3.12 (d, / = 7.8 Hz, 2H), 2.63 (d, / = 9.1 Hz, 1H), 2.40 (s, 1H), 2.25 (s, 1H), 2.07 (d, / = 9.3 Hz, 1H), 1.89 (s, 1H), 1.84 1.70 (m, 1H), 1.54 (s, 3H), 1.29 (s, 1H); LC-MS (ESI+) m/z 478 (M+H) ⁺ , RT = 1.91 minutes.

Example 21

5 - [(3 -phenylpropyl) (3,4,5 -triethoxybenzoyl) amino] pentanoic acid

[00550] Example 21 was prepared according to the procedure used for the preparation of Example 4, substituting 3,4,5-triethoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 7.23 (t, / = 7.3 Hz, 2H), 7.14 (t, / = 7.2 Hz, 3H), 6.52 (s, 2H), 4.04 - 3.96 (m, 6H), 3.28 (s, 4H), 2.52 (d, / = 5.4 Hz, 2H), 2.16 (s, 2H), 1.89 - 1.79 (m, 2H), 1.52 (d, / = 7.7 Hz, 2H), 1.48 - 1.38 (m, 2H), 1.30 (t, / = 6.9 Hz, 6H), 1.24 (t, / = 7.0 Hz, 3H), T = 60 °C; LC-MS (ESI+) m/z 472.2 (M+H) ⁺ , RT = 1.981 minutes.

Example 22

5 - [(3 -methoxy-4-nitrobenzoyl) (3 -phenylpropyl)amino] pentanoic acid

[00551] Example 22 was prepared according to the procedure used for the preparation of Example 4, substituting 3-methoxy-4-nitrobenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 12.07 (s, 1H), 7.86 (dd, / = 37.2, 8.2 Hz, 1H), 7.31 - 7.23 (m, 2H), 7.21 - 7.12 (m, 2H), 7.10 - 6.89 (m, 3H), 3.90 (d, / = 21.2 Hz, 3H), 3.42 (q, / = 7.6 Hz, 2H), 3.09 (dt, / = 22.8, 7.7 Hz, 2H), 2.63 (t, / = 7.8 Hz, 1H), 2.41 (d, / = 7.3 Hz, 1H), 2.26 (t, / = 6.8 Hz, 1H), 2.07 (d, / = 4.6 Hz, 1H), 1.97 - 1.85 (m, 1H), 1.77 (t, / = 7.9 Hz, 1H), 1.63 - 1.52 (m, 2H), 1.47 (q, / = 7.4, 7.0 Hz, 1H), 1.29 (q, / = 7.5 Hz, 1H), T = 25 °C; LC-MS (ESI+) m/z 415.2 (M+H) ⁺ , RT = 1.853 minutes. Example 23

5-[(3,4-dihydro-2H-l,5-benzodioxepine-7-carbonyl)(3-phenylpr opyl)amino]pentanoic acid

[00552] Example 23 was prepared according to the procedure used for the preparation of Example 4, substituting 3,4-dihydro-2H-benzo[Z?][l,4]dioxepine-7-carboxylic acid for 3,5-dimethoxy-4- methylbenzoic acid, to provide the titled compound. ¾ NMR (400 MHz, DMSO- ¾) δ ppm 7.24 (dd, / = 8.4, 6.4 Hz, 2H), 7.14 (t, / = 7.4 Hz, 3H), 6.96 -6.90 (m, 1H), 6.86 (s, 1H), 6.86 - 6.83 (m, 1H), 4.15 (dt, / = 7.7, 5.5 Hz, 4H), 3.28 (s, 4H), 2.57 2.49 (m, 2H), 2.19 - 2.06 (m, 4H), 1.81 (p, / = 7.9 Hz, 2H), 1.51 (t, / = 7.6 Hz, 2H), 1.42 (s, 2H), T = 60 °C; LC-MS (ESI+) m/z 412.2 (M+H) ⁺ , RT = 1.849 minutes.

Example 24

5-[(7-methoxy-l-benzofuran-5-carbonyl)(3-phenylpropyl)amino] pentanoic acid

[00553] Example 24 was prepared according to the procedure used for the preparation of Example 4, substituting 7-methoxybenzofuran-5-carboxylic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO- d ₆ ) δ ppm 7.97 (d, / = 2.1 Hz, 1H), 7.18 (s, 2H), 7.14 (s, 1H), 7.12 (d, / = 12.8 Hz, 3H), 6.93 (d, / = 2.2 Hz, 1H), 6.80 (d, / = 1.3 Hz, 1H), 3.93 (s, 3H), 3.31 (s, 6H), 2.16 (s, 2H), 1.92 - 1.80 (m, 2H), 1.59 - 1.50 (m, 2H), 1.44 (s, 2H), T = 60 °C; LC- MS (ESI+) m/z 410.2 (M+H) ⁺ , RT = 1.874 minutes.

Example 25

5-[(3-phenylpropyl){ l-[4-(trifluoromethoxy)phenyl]cyclopropane-l-carbonyl}amino] pentanoic acid

[00554] Example 25 was prepared according to the procedure used for the preparation of Example 4, substituting l-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid for 3,5-dimethoxy-4- methylbenzoic acid, to provide the titled compound. ¾ NMR (400 MHz, DMSO- ¾) δ ppm 7.40 7.08 (m, 8H), 7.04 6.92 (m, 1H), 3.19 (dt, / = 15.4, 6.7 Hz, 4H), 2.49 (d, / = 1.9 Hz, 2H), 2.27 (t, / = 7.6 Hz, 1H), 2.20 (t, / = 6.7 Hz, 1H), 1.96 (t, / = 7.3 Hz, 1H), 1.85 1.63 (m, 1H), 1.39 (q, / = 7.8, 6.8 Hz, 3H), 1.24 (d, / = 4.4 Hz, 1H), 1.22 1.12 (m, 3H), 1.02 (dd, / = 11.2, 6.8 Hz, 2H); LC-MS (ESI+) m/z 464 (M+H) ⁺ , RT = 2.06 minutes.

Example 26

5- { (3-phenylpropyl) [3-(trifluoromethoxy)benzoyl] amino jpentanoic acid

[00555] Example 26 was prepared according to the procedure used for the preparation of Example 4, substituting 3-(trifluoromethoxy)benzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 12.00 (s, 1H), 7.51 (dd, / = 24.8, 7.9 Hz, 1H), 7.45 7.31 (m, 2H), 7.27 (d, / = 12.3 Hz, 3H), 7.20 7.05 (m, 2H), 7.00 (d, / = 7.4 Hz, 1H), 3.41 (d, / = 6.9 Hz, 3H), 3.19 2.99 (m, 2H), 2.61 (d, / = 8.1 Hz, 1H), 2.35 (t, / = 7.4 Hz, 1H), 2.24 (d, / = 6.6 Hz, IH), 2.03 (t, / = 7.3 Hz, IH), 1.88 (s, IH), 1.75 (s, IH), 1.48 (d, / = 43.7 Hz, 4H), 1.31 1.15 (m, IH); LC-MS (ESI+) nt/z 424 (M+H) ⁺ , RT = 1.98 minutes.

Example 27

5- { [ 1 -(2H- 1 ,3 -benzodioxol-5 -yl)cyclopropane- 1 -carbonyl] (3-phenylpropyl)amino jpentanoic acid

[00556] Example 27 was prepared according to the procedure used for the preparation of Example 4, substituting l-(benzo[(f][l,3]dioxol-5-yl)cyclopropanecarboxylic acid for 3,5-dimethoxy-4- methylbenzoic acid, to provide the titled compound. ¾ NMR (400 MHz, DMSO- ¾) δ ppm 11.98 (s, IH), 7.34 7.23 (m, 2H), 7.17 (td, / = 8.2, 7.6, 3.9 Hz, 2H), 7.12 7.00 (m, IH), 6.90 6.47 (m, 3H), 5.96 (s, 2H), 3.19 (p, / = 7.1, 5.9 Hz, 4H), 2.49 (d, / = 1.9 Hz, 2H), 2.30 (t, / = 7.6 Hz, IH), 2.19 (s, IH), 2.04 (d, / = 14.7 Hz, IH), 1.71 (p, / = 7.8 Hz, IH), 1.47 1.31 (m, 3H), 1.21 (q, / = 7.2 Hz, IH), 1.17 1.01 (m, 4H), 0.92 (q, / = 4.6 Hz, IH); LC-MS (ESI+) nt/z 424 (M+H) ⁺ , RT = 1.91 minutes.

Example 28

5-[(3-methoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pentanoi c acid

[00557] The titled compound was prepared according to the procedure used for the preparation of Example 4, substituting 3-methoxy-4-methylbenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid. *H NMR (400 MHz, DMSO-<¾) δ ppm 12.00 (s, IH), 7.14 (t, / = 45.3 Hz, 6H), 6.76 (m, 2H), 3.76 (s, 3H), 3.38 (s, 2H), 3.15 (s, 2H), 2.61 (s, IH), 2.37 (s, IH), 2.24 (s, IH), 2.14 (s, 3H), 2.06 (s, IH), 1.82 (d, / = 31.2 Hz, 2H), 1.52 (s, 3H), 1.26 (s, IH); LC-MS (ESI+) nt/z 398 (M+H) ⁺ , RT = 1.82 minutes.

Example 29

5-{ [3-methoxy-5-(trifluoromethoxy)benzoyl](3-phenylpropyl)amino }pentanoic acid

[00558] Example 29 was prepared according to the procedure used for the preparation of Example 4, substituting 3-methoxy-5-(trifluoromethoxy)benzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 12.01 (s, IH), 7.37 - 7.20 (m, 2H), 7.20 - 7.07 (m, 2H), 7.05 -6.91 (m, 2H), 6.84 (t, / = 15.3 Hz, 2H), 3.79 (d, / = 8.0 Hz, 3H), 3.38 (s, 2H), 3.09 (q, / = 9.2, 8.1 Hz, 2H), 2.66 - 2.57 (m, IH), 2.37 (t, / = 7.4 Hz, IH), 2.25 (d, / = 7.5 Hz, IH), 2.03 (d, / = 7.5 Hz, IH), 1.88 (d, / = 8.2 Hz, IH), 1.75 (s, IH), 1.51 (d, / = 15.2 Hz, 2H), 1.44 (s, IH), 1.25 (s, IH), T = 25 °C; LC-MS (ESI+) nt/z 454.2 (M+H) ⁺ , RT = 2.002 minutes.

Example 30

5-[(2,4-difluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino] pentanoic acid

[00559] Example 30 was prepared according to the procedure used for the preparation of Example 4, substituting 2,4-difluoro-3,5-dimethoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 11.72 (s, IH), 7.33 - 7.05 (m, 4H), 6.99 (d, / = 7.3 Hz, 1H), 6.74 (ddd, / = 21.4, 8.6, 5.5 Hz, 1H), 3.91 (d, / = 21.2 Hz, 3H), 3.81 (d, / = 13.3 Hz, 3H), 3.49 - 3.38 (m, 2H), 3.18 - 3.02 (m, 7H), 2.63 (t, / = 7.8 Hz, 1H), 2.42 (t, / = 7.3 Hz, 1H), 2.25 (t, / = 6.9 Hz, 1H), 2.11 - 2.02 (m, 1H), 1.89 (p, / = 7.7 Hz, 1H), 1.75 (p, / = 7.3 Hz, 1H), 1.57 (dq, / = 15.4, 7.5 Hz, 2H), 1.45 (p, / = 7.4 Hz, 1H), 1.31 (p, / = 7.4 Hz, 1H); LC-MS (ESI+) m/z 436.4 (M+H) ⁺ , RT = 1.899 minutes.

Example 31

5-[(4-methoxy-2-methyl-l-benzofuran-6-carbonyl)(3-phenylprop yl)amino]pentanoic acid

[00560] Example 31 was prepared according to the procedure used for the preparation of Example 4, substituting 4-methoxy-2-methylbenzofuran-6-carboxylic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. Ή NMR (400 MHz, DMSO-<¾) δ ppm 7.45 - 6.90 (m, 6H), 6.62 (d, / = 15.3 Hz, 2H), 3.87 (s, 4H), 3.42 (s, 2H), 3.20 (s, 2H), 2.45 (s, 4H), 2.27 (s, 1H), 1.84 (s, 2H), 1.55 (s, 3H), 1.38 - 1.16 (m, 1H); LC-MS (ESI+) m/z 424.4 (M+H) ⁺ , RT = 1.955 minutes.

Example 32

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(2-fluorophenyl)propyl] arnino}pentanoic acid

[00561] Example 32 was prepared according to the procedure used for the preparation of Example 11, substituting 3-(2-fluorophenyl)propan-l-amine for 3-(o-tolyl)propan-l -amine, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.33 - 7.10 (m, 2H), 7.05 (t, / = 8.9 Hz, 2H), 6.48 (s, 2H), 3.75 (s, 6H), 3.29 (s, 4H), 2.55 (s, 2H), 2.17 (s, 2H), 2.00 (s, 3H), 1.84 (s, 2H), 1.56 (d, / = 9.3 Hz, 2H), 1.44 (s, 2H), T = 60 °C; LC-MS (ESI+) m/z 432.2 (M+H) ⁺ , RT = 1.945 minutes.

Example 33

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(3-fluorophenyl)propyl] amino}pentanoic acid

[00562] Example 33 was prepared according to the procedure used for the preparation of Example 11, substituting 3-(3-fluorophenyl)propan-l-amine for 3-(o-tolyl)propan-l -amine, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.25 (d, / = 7.3 Hz, 1H), 7.08 - 6.84 (m, 3H), 6.49 (s, 2H), 3.76 (s, 6H), 3.29 (s, 4H), 2.54 (s, 2H), 2.16 (d, / = 7.1 Hz, 2H), 2.00 (s, 3H), 1.85 (s, 2H),

I.55 (s, 2H), 1.44 (s, 2H), T = 60 °C; LC-MS (ESI+) m/z 432.2 (M+H) ⁺ , RT = 1.940 minutes.

Example 34

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4-fluorophenyl)propyl] arnino}pentanoic acid

[00563] Example 34 was prepared according to the procedure used for the preparation of Example

I I, substituting 3-(4-fluorophenyl)propan-l-amine for 3-(o-tolyl)propan-l -amine, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 12.03 (s, 1H), 7.27 (s, 1H), 6.99 (d, / = 35.2 Hz, 3H), 6.45 (s, 2H), 3.74 (d, / = 4.8 Hz, 6H), 3.37 (s, 2H), 3.13 (s, 2H), 2.61 (s, 1H), 2.38 (s, 1H), 2.25 (s, 1H), 2.07 (d, / = 9.0 Hz, 1H), 1.98 (s, 3H), 1.81 (d, / = 33.9 Hz, 2H), 1.53 (s, 3H), 1.29(s,lH), T = 25 °C; LC-MS (ESI+) m/z 432.2 (M+H) ⁺ , RT = 1.943 minutes.

Example 35

5-[(4-cyclopropyl-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino ]pentanoic acid

[00564] Step 1 : methyl 5-[(4-cyclopropyl-3,5-dimethoxybenzoyl)(3- phenylpropyl) amino] pentanoate

[00565] To a mixture of methyl 5-[(4-bromo-3,5-dimethoxybenzoyl)(3- phenylpropyl) amino] pentanoate (47.0 mg, 0.095 mmol) (prepared according to the procedure of Example 20), cyclopropylboronic acid (12.3 mg, 0.143 mmol) and tricyclohexylphosphine (5.35 mg, 0.019 mmol), potassium phosphate tribasic (60.8 mg, 0.286 mmol) in the co-solvent of toluene (1.0 mL) and water (0.15 mL) was added palladium(II) acetate (2.14 mg, 9.55 μπιοΐ). Then the mixture was bubbled with N ₂ for 2-3 minutes and heated to 110 °C for 2 hours. Then the mixture was cooled down and extracted with ethyl acetate 3 times. The combined organic layers were washed brine once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (50% -100%) to give the titled compound. LC-MS (ESI+) m/z 454.2 (M+H) ⁺ , RT = 2.157 minutes.

[00566] Step 2: 5-[(4-cyclopropyl-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino ]pentanoic acid

[00567] To a solution of methyl 5-[(4-cyclopropyl-3,5-dimethoxybenzoyl)(3- phenylpropyl) amino] pentanoate (43.1 mg, 0.095 mmol) in tetrahydrofuran (2 mL) was added aqueous lithium hydroxide solution.(1.0 N, 0.57 mL). The mixture was stirred at room temperature overnight. The mixture was acidified with 1 N hydrochloric acid to adjust pH = 3. Then the mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue that was purified by preparative HPLC and lyophilized to give the titled compound. ¾ NMR (400 MHz, DMSO-<¾) δ ppm 12.01 (s, 1H), 7.21 (d, / = 33.0 Hz, 4H), 7.03 (s, 1H), 6.45 (s, 2H), 3.70 (s, 6H), 3.37 (s, 2H), 3.15 (s, 2H), 2.61 (s, 1H), 2.40 (s, 1H), 2.24 (s, 1H), 2.06 (s, 1H), 1.84 (tt, / = 8.8, 5.6 Hz, 3H), 1.51 (s, 3H), 1.29 (s, 1H), 0.94 (m, 2H), 0.74 (m, 2H), T = 25 °C; LC-MS (ESI+) m/z 440.2 (M+H) ⁺ , RT = 1.994 minutes.

Example 36

5-{ [3-(4-chlorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl)ami no}pentanoic acid

[00568] Example 36 was prepared according to the procedure used for the preparation of Example 11, substituting 3-(4-chlorophenyl)propan-l-amine for 3-(o-tolyl)propan-l -amine, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 11.93 (s, 1H), 7.30 (d, / = 16.9 Hz, 2H), 7.19 (s, 1H), 7.03 (s, 1H), 6.56 - 6.37 (m, 2H), 3.74 (d, / = 6.4 Hz, 6H), 3.37 (s, 2H), 3.13 (s, 2H), 2.61 (s, 1H), 2.39 (s, 1H), 2.25 (s, 1H), 2.07 (d, / = 8.7 Hz, 1H), 1.98 (s, 3H), 1.84 (dd, / = 30.7, 17.8 Hz, 2H), 1.52 (s, 3H), 1.28 (s, 1H), T = 25 °C; LC-MS (ESI+) m/z 448.2 (M+H) ⁺ , RT = 2.001 minutes.

Example 37

5-{ [3,5-dimethoxy-4-(trifluoromethyl)benzoyl](3-phenylpropyl)am ino}pentanoic acid

[00569] Step 1 : methyl 4-bromo-3,5-dimethoxybenzoate

[00570] To a mixture of 4-bromo-3,5-dimethoxybenzoic acid (900 mg, 3.45 mmol) in N,N- dimethylformamide (10 mL) was added potassium carbonate (953 mg, 6.89 mmol) and then methyl iodide (0.259 mL, 4.14 mmol). The mixture was stirred at room temperature for 1 hour. Then water (30 mL) was added to the mixture, and the mixture was extracted with ethyl acetate (40 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give the titled compound. 'H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.25 (s, 2H), 3.96 (s, 6H), 3.94 (s, 3H); LC-MS (ESI+) m/z 275.0, 277.0 (M+H) ⁺ , RT = 1.878 minutes.

[00571] Step 2: methyl 3,5-dimethoxy-4-(trifluoromethyl)benzoate

[00572] To a mixture of methyl 4-bromo-3,5-dimethoxybenzoate (100 mg, 0.364 mmol), copper(I) iodide (13.9 mg, 0.073 mmol) and cesium trifluoroacetate (107 mg, 0.436 mmol) in dry N,N- dimethylformamide (0.5 mL) was added methyl trifluoroacetate (186 mg, 1.45 mmol). Then the mixture was purged with N ₂ for 2-3 minutes and heated to 160 °C overnight. Then additional copper(I) iodide (13.9 mg, 0.073 mmol), cesium trifluoroacetate (107 mg, 0.436 mmol) and 1,10- phenanthroline (13.1 mg, 0.073 mmol) were added to the mixture. The mixture was purged with N ₂ for 2-3 minutes and heated to 160 °C again. Methyl trifluoroacetate (186 mg, 1.45 mmol) was added dropwise over 10 minutes, and additional methyl trifluoroacetate (186 mg, 1.45 mmol) was added 30 minutes later. The mixture was heated for 3 hours. Then the mixture was cooled down to room temperature and teri-butyl methyl ether (4 mL) was added. The mixture was filtered, and the solids were washed with teri-butyl methyl ether. The filtrate was concentrated in vacuo to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-15%) to give the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.28 (d, / = 0.9 Hz, 2H), 3.90 (s, 6H), 3.89 (s, 3H); LC-MS (ESI+) m/z 265.0 (M+H) ⁺ , RT = 1.953 minutes.

[00573] Step 3: 3,5-dimethoxy-4-(trifluoromethyl)benzoic acid

[00574] To a solution of methyl 3,5-dimethoxy-4-(trifluoromethyl)benzoate (69.0 mg, 0.261 mmol) in dioxane (2 mL) was added aqueous lithium hydroxide solution.(1.0 N, 1.57 mL). The mixture was stirred at room temperature overnight. The mixture was acidified with 1 N hydrochloric acid to adjust pH = 2. Then the mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give the titled compound. LC-MS (ESI+) m/z 251.0 (M+H) ⁺ , RT = 1.758 minutes. [00575] Step 4: 5-{ [3,5-dimethoxy-4-(trifluoromethyl)benzoyl](3-phenylpropyl)am ino}pentanoic acid

[00576] The titled compound was prepared according to the procedure used for the preparation of Example 4, substituting 3,5-dimethoxy-4-(trifluoromethyl)benzoic acid for 3,5-dimethoxy-4- methylbenzoic acid, to provide the titled compound. ¾ NMR (400 MHz, DMSO- ¾) δ ppm 12.04 (s, 1H), 7.43 - 6.93 (m, 5H), 6.65 (d, / = 18.1 Hz, 2H), 3.81 (d, / = 18.9 Hz, 6H), 3.40 (q, / = 7.7, 7.3 Hz, 2H), 3.10 (dt, / = 15.8, 7.4 Hz, 2H), 2.63 (t, / = 8.0 Hz, 1H), 2.42 (t, / = 7.3 Hz, 1H), 2.26 (t, / = 6.8 Hz, 1H), 2.08 (t, / = 7.2 Hz, 1H), 1.84 (dt, / = 41.0, 7.2 Hz, 2H), 1.67 - 1.41 (m, 3H), 1.39 - 1.22 (m, 1H), T = 25 °C; LC-MS (ESI+) nt/z 468.2 (M+H) ⁺ , RT = 1.954 minutes.

Example 38

5-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl)ami no}pentanoic acid

[00577] Example 38 was prepared according to the procedure used for the preparation of Example 11 , substituting 3-(3-chlorophenyl)propan-l-amine for 3-(o-tolyl)propan-l -amine, to provide the titled compound. *H NMR (400 MHz, DMSO- ₆ ) δ ppm 11.81 (s, 1H), 7.35 - 7.15 (m, 3H), 7.10 (s, 1H), 6.49 (s, 2H), 3.76 (s, 6H), 3.29 (s, 4H), 2.53 (s, 2H), 2.17 (s, 2H), 2.00 (s, 3H), 1.87 (d, / = 22.2 Hz, 2H), 1.55 (s, 2H), 1.44 (s, 2H), T = 60 °C; LC-MS (ESI+) nt/z 448.2 (M+H) ⁺ , RT = 1.998 minutes.

Example 39

5- [(2-chloro-3 , 5 -dimethoxybenzoyl) (3 -phenylpropyl)amino] pentanoic acid

[00578] Step 1 : 3,5-dimethoxy-2-nitrobenzoic acid

[00579] To 3,5-dimethoxybenzoic acid (4.01 g, 22 mmol) in acetic anhydride (25 mL, 264 mmol) was added nitric acid (3.95 mL, 95 mmol) slowly at 0 °C. The mixture was stirred at 0 °C for 1 hour, and then warmed to room temperature for 1 hour. The mixture was poured into 150 g of ice water. The solid was collected by filtration, and washed with water (3 x 5 mL). The solid was dried under vacuum to give the titled compound, 4.65 g (93% yield). Ή NMR (400 MHz, DMSO-<¾) δ ppm 7.05 (d, / = 2 Hz, 1H), 6.97 (d, / = 2 Hz, 1H), 3.91 (s, 3H), 3.88 (s, 3H); MS (ESI-) m/z 226 (M-H) .

[00580] Step 2: methyl 3,5-dimethoxy-2-nitrobenzoate

[00581] 3,5-Dimethoxy-2-nitrobenzoic acid (1 g, 4.40 mmol, Step 1) was dissolved in CH ₃ OH (10 mL) and cooled to 0 °C. Concentrated sulfuric acid (1.98 g, 20.19 mmol) was added slowly, and then the reaction mixture was stirred at 70 °C for 6 hours. The mixture was poured into ice water. The solid was collected by filtration and dried to give the titled compound, 1 g (94 % yield). 'H NMR (400 MHz, DMSO-<¾) δ ppm 7.07 (d, / = 2.5 Hz, 1H), 6.97 (d, / = 2.5 Hz, 1H), 3.91 (s, 3H), 3.89 (s, 3H), 3.81 (s, 3H).

[00582] Step 3: methyl 2-amino-3,5-dimethoxybenzoate [00583] A solution of methyl 3,5-dimethoxy-2-nitrobenzoate (700 mg, 2.90 mmol, Step 2) in CH ₃ OH (5 mL) and tetrahydrofuran (5mL) was stirred for 12 hours under H ₂ (15 psi) in the presence of 10% Pd/charcoal (535 mg). The catalyst was removed by filtration through Celite®, and the filtrate was concentrated in vacuo to give the titled compound (600 mg, 98 % yield). LC-MS (ESI+) m/z 212 (M+H) ⁺ .

[00584] Step 4: methyl 2-chloro-3,5-dimethoxybenzoate

[00585] A mixture of methyl 2-amino-3,5-dimethoxybenzoate (220 mg, 1.042 mmol, Step 3) and 2 N hydrochloric acid (0.1 mL) was stirred at 0 °C for 3 minutes. Then sodium nitrite (79 mg, 1.146 mmol) in water (1 mL) was added dropwise, and the mixture was stirred for 30 minutes at 0 °C. Copper(I) chloride (516 mg, 5.21 mmol) in 2 N HC1 (1 mL) was added at room temperature, and the mixture was stirred at room temperature overnight. A saturated aqueous ammonium chloride solution was added to the reaction mixture followed by extraction with CH ₂ C1 ₂ (10 mL x 2). The combined organic fractions were dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-50%) to give 70 mg (29% yield) of the titled compound. LC-MS (ESI+) m/z 231 (M+H) ⁺ .

[00586] Step 5: 2-chloro-3,5-dimethoxybenzoic acid

[00587] A mixture of methyl 2-chloro-3,5-dimethoxybenzoate (45 mg, 0.195 mmol, Step 4) in tetrahydrofuran (2 mL) and lithium hydroxide (14.02 mg, 0.585 mmol) in water (1 mL) was stirred at room temperature for 2 hours. Then 1 N HC1 was added dropwise to pH ~ 6. The mixture was extracted with ethyl acetate. The organic phase was dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give 40 mg (95% yield) of the titled compound. LC-MS (ESI+) m/z 217 (M+H) ⁺ .

[00588] Step 6: 5-[(2-chloro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pent anoic acid

[00589] 5-[(2-Chloro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pent anoic acid was prepared according to the procedure used for the preparation of Example 4, substituting 2-chloro-3,5- dimethoxybenzoic acid (Step 5) for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.35 - 7.23 (m, 2H), 7.22 - 7.08 (m, 2H), 7.00 (dd, / = 6.8, 1.7 Hz, 1H), 6.69 (dd, / = 21.7, 2.7 Hz, 1H), 6.44 (dd, / = 10.5, 2.7 Hz, 1H), 3.86 (d, / = 3.2 Hz, 3H), 3.78 (d, / = 6.9 Hz, 3H), 3.21 (td, / = 13.4, 6.6 Hz, 1H), 3.15 - 3.01 (m, 1H), 2.97 (dd, / = 12.7, 7.4 Hz, 1H), 2.65 (s, 1H), 2.39 (p, / = 7.1 Hz, 1H), 2.26 (t, / = 6.9 Hz, 1H), 2.07 (t, / = 7.3 Hz, 1H), 1.86 (d, / = 24.8 Hz, 1H), 1.63 - 1.51 (m, 2H), 1.49 - 1.19 (m, 2H); LC-MS (ESI+) m/z 434.2 (M+H) ⁺ , RT = 1.874 minutes.

Example 40

5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) { 3 - [3 -(trifluoromethyl)phenyl] propyl } amino]pentanoic acid

[00590] Example 40 was prepared according to the procedure used for the preparation of Example 11, substituting 3-(3-(trifluoromethyl)phenyl)propan-l-amine for 3-(o-tolyl)propan-l -amine, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.79 - 7.23 (m, 4H), 6.49 (d, / = 13.8 Hz, 2H), 3.75 (d, / = 10.7 Hz, 9H), 3.41 (s, 2H), 2.75 (s, IH), 2.27 (s, IH), 2.10 (s, IH), 1.99 (s, 3H), 1.88 (d, J = 33.6 Hz, 2H), 1.55 (s, 3H), 1.31 (s, IH), T = 60 °C; LC-MS (ESI+) m/z 481.2 (M+H) ⁺ , RT = 2.024 minutes.

Example 41

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylthiophen-2-yl) propyl]amino}pentanoic acid

[00591] Example 41 was prepared according to the procedure used for the preparation of Example 11, substituting 3-(5-methylthiophen-2-yl)propan-l-amine for 3-(o-tolyl)propan-l -amine, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 6.51 (s, 4H), 3.77 (s, 6H), 3.65 (m, 2H), 3.55 (m, 3H), 3.18 (s, 3H), 2.77 (s, IH), 2.42 - 2.18 (m, 4H), 2.10 (s, IH), 2.01 (s, 3H), 1.85 (d, / = 39.4 Hz, 2H), 1.55 (s, 3H), 1.31 (s, IH); LC-MS (ESI+) m/z 434.2 (M+H) ⁺ , RT = 1.978 minutes.

Example 42

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4-methylphenyl)propyl] amino}pentanoic acid

[00592] Example 42 was prepared according to the procedure used for the preparation of Example 11, substituting 3-(/?-tolyl)propan-l -amine for 3-(o-tolyl)propan-l-amine, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.11 (s, 2H), 6.98 (s, 2H), 6.49 (s, 2H), 3.76 (s, 6H), 3.39 (s, 2H), 3.15 (s, 2H), 2.58 (s, IH), 2.36 (s, IH), 2.32 - 2.18 (m, 4H), 2.10 (s, IH), 2.01 (s, 3H), 1.82 (d, / = 29.4 Hz, 2H), 1.54 (s, 3H), 1.30 (s, IH); LC-MS (ESI+) m/z 428.2 (M+H) ⁺ , RT =

I.978 minutes.

Example 43

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4-methoxyphenyl)propyl ]amino}pentanoic acid

[00593] Example 43 was prepared according to the procedure used for the preparation of Example

I I, substituting 3-(4-methoxyphenyl)propan-l-amine for 3-(o-tolyl)propan-l -amine, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 11.47 (s, IH), 7.17 (s, IH), 6.94 (s, IH), 6.86 (s, IH), 6.74 (s, IH), 6.49 (d, 2H), 3.76 (s, 6H), 3.71 (s, 3H), 3.39 (m, 2H), 3.15 (m, 2H), 2.35 (s, IH), 2.27 (s, IH), 2.10 (s, IH), 2.00 (s, 3H), 1.85 (s, IH), 1.77 (s, IH), 1.54 (s, 3H), 1.31 (s, IH); LC- MS (ESI+) m/z 444.2 (M+H) ⁺ , RT = 1.917 minutes.

Example 44

({2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)arnino]e thyl}sulfanyl)acetic acid

[00594] Step 1 : N-(2-chloroethyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)b enzamide

[00595] To a solution of N-(2-hydroxyethyl)-3,5-dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide (100 mg, 0.280 mmol, Example 6-Step 4) in CH ₂ C1 ₂ (3 mL) was added diisopropylethylamine (0.147 mL, 0.839 mmol). The solution was cooled down to 0 °C, and methanesulfonyl chloride (0.044 mL, 0.560 mmol) in CH ₂ C1 ₂ (0.5 mL) was added dropwise. After addition, the solution was stirred at room temperature for 1 hour. The solution was concentrated, and the residue was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-60%) to give the titled compound. LC-MS (ESI+) m/z 376.2 (M+H) ⁺ , RT = 2.136 minutes.

[00596] Step 2: ethyl ({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl)amino]ethyl}sulfanyl)acetate

[00597] To a mixture of N-(2-chloroethyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)b enzamide (210 mg, 0.559 mmol) in dimethyl sulfoxide (3 mL) and acetone (3 mL) was added ethyl 2- mercaptoacetate (33.6 mg, 0.279 mmol) and K ₂ C0 ₃ (77.0 mg, 0.559 mmol) at room temperature. The mixture was stirred at room temperature overnight. Then water (20 mL) was added, and the mixture was extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by flash chromatography on silica eluted with hexane and ethyl acetate (0-35%) to give the titled compound. LC-MS (ESI+) m/z 460 (M+H) ⁺ , RT = 2.14 minutes.

[00598] Step 3: ({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl)amino]ethyl}sulfanyl)acetic acid

[00599] To a mixture of ethyl ({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl)amino]ethyl}sulfanyl)acetate (111 mg, 0.241 mmol) in tetrahydrofuran (2 mL) was added aqueous lithium hydroxide solution.(1.0 N, 1.45 mL). The mixture was stirred at room temperature for 1 hour. The mixture was acidified with 1 N hydrochloric acid to adjust pH = 2-3. Then the mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue that was purified by preparative HPLC and lyophilized to give the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.42 - 6.95 (m, 5H), 6.54 (s, 2H), 3.76 (s, 6H), 3.60 (m, 2H), 3.35 (m, 2H), 3.21 (s, 1H), 3.05 (s, 1H), 2.80 (d, 2H), 2.63 (s, 1H), 2.42 (s, 1H), 2.01 (s, 3H), 1.84 (s, 2H); LC-MS (ESI+) m/z 432.2 (M+H) ⁺ , RT = 1.945 minutes.

Example 45

N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycyl-2 -methylalanine

[00600] Example 45 was prepared according to the procedure used for the preparation of Example 2, substituting methyl 2-amino-2-methylpropanoate for methyl 1-aminocyclohexanecarboxylate, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.94 (brs, 1H), 7.33-7.00 (m, 5H), 6.61 (brs, 2H), 3.92 (brs, 2H), 3.75 (s, 6H), 3.32 (brs, 2H), 2.54 (brs, 2H), 2.00 (s, 3H), 1.85 (brs, 2H), 1.36 (s, 6H); LC-MS (ESI+) m/z 457 (M+H) ⁺ , RT = 1.85 minutes. Example 46

N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycylph enylalanine

[00601] Example 46 was prepared according to the procedure used for the preparation of Example 2, substituting methyl 2-amino-3-phenylpropanoate for methyl 1 -aminocyclohexanecarboxylate, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 8.09 (brs, 1H), 7.37 6.95 (m, 10H), 6.57 (s, 2H), 4.53 (td, / = 8.5, 5.2 Hz, 1H), 3.89 (brs, 2H), 3.71 (s, 6H), 3.18 (brs, 2H), 3.07 (dd, / = 13.9, 5.2 Hz, 2H), 2.91-2.89 (m, 2H), 1.99 (s, 3H), 1.77 (s, 2H); LC-MS (ESI+) m/z 519 (M+H) ⁺ , RT = 1.97 minutes.

Example 47

N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycyl-3 -thiophen-2-ylalanine

[00602] Example 47 was prepared according to the procedure used for the preparation of Example 2, substituting methyl 2-amino-3-(thiophen-2-yl)propanoate for methyl 1- aminocyclohexanecarboxylate, to provide the titled compound. 'H NMR (400 MHz, DMSO-ife) δ ppm 12.42 (brs, 1H), 8.62 (d, / = 8.2 Hz, 1H), 7.44 - 7.32 (m, 1H), 7.29-7.11 (m, 4H), 7.03 - 6.92 (m, 3H), 6.63 (s, 1H), 6.54 (s, 1H), 5.44 (d, / = 7.9 Hz, 1H), 4.05 (d, / = 11.9 Hz, 1H), 3.84 (s, 1H), 3.74 (s, 3H), 3.66 (s, 3H), 3.22-3.17 (m, 1H), 2.80 - 2.73 (m, 2H), 2.60-2.53 (m, 1H), 2.42-2.36 (m, 2H), 1.99 (s, 1H), 1.96 (s, 2H), 1.86-1.80 (m, 2H); LC-MS (ESI+) m/z 525 (M+H) ⁺ , RT = 1.93 minutes.

Example 48

5-[(2,6-dimethoxypyridine-4-carbonyl)(3-phenylpropyl)amino]p entanoic acid

[00603] Example 48 was prepared according to the procedure used for the preparation of Example 4, substituting 2,6-dimethoxyisonicotinic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.32-7.06 (m, 4H), 7.05-6.98 (m, 1H), 6.24 (s, 1H), 6.18 (s, 1H), 3.85 (d, / = 2.1 Hz, 6H), 3.37 (q, / = 7.1 Hz, 2H), 3.07 (dt, / = 19.2, 7.6 Hz, 2H), 2.60 (t, / = 7.8 Hz, 1H), 2.39 (t, / = 7.4 Hz, 1H), 2.23 (t, / = 6.8 Hz, 1H), 2.07 (d, / = 6.1 Hz, 1H), 1.89 1.81 (m, 1H), 1.56 1.39 (m, 3H), 1.27 (p, / = 7.4 Hz, 1H); LC-MS (ESI+) m/z 401 (M+H) ⁺ , RT =

I.87 minutes.

Example 49

5-{ [3-(2,4-dichlorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}pentanoic acid

[00604] Example 49 was prepared according to the procedure used for the preparation of Example

I I, substituting 3-(2,4-dichlorophenyl)propan-l -amine for 3-(o-tolyl)propan-l -amine, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 11.83 (s, 1H), 7.46 (s, 1H), 7.27 (s, 2H), 6.47 (s, 2H), 3.75 (s, 6H), 3.30 (s, 2H), 3.14 (s, 2H), 2.67 - 2.52 (m, 2H), 2.17 (s, 2H), 2.00 (s, 3H), 1.81 (s, 2H), 1.56 (s, 2H), 1.45 (s, 2H), T = 60 °C; LC-MS (ESI+) m/z 482.2 ,484.2 (M+H) ⁺ , RT = 2.074 minutes.

Example 50

( { 2- [(3 , 5 -dimethoxy-4-methylbenzoyl)(3 -phenylpropyl) amino] ethoxy } methyl)phosphonic acid

[00605] Step l : diethyl ({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy } methyl)phosphonate

[00606] To a solution of N-(2-hydroxyethyl)-3,5-dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide (40 mg, 0.112 mmol, Example 6-Step 4) in tetrahydrofuran (2 mL) was added NaH (13.43 mg, 0.336 mmol), and the mixture was stirred at room temperature for 1 hour. (Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate (108 mg, 0.336 mmol) was added, and stirring was continued overnight. The reaction was quenched with water (15 mL), and the mixture was extracted with ethyl acetate (10 mL x 3). The organic phase was concentrated. Flash

chromatography on silica gel (0-100% ethyl acetate in hexanes) gave the titled compound (40 mg, 0.059 mmol, 52.8 % yield) that was used directly in the next step. MS (APCI ⁺ ) m/z 508.2 (M+H) ⁺ .

[00607] Step 2: ({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy } methyl)phosphonic acid

[00608] To a solution of diethyl ({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy} me thyl)phosphonate (40 mg, 0.079 mmol, Step 1) in dichloromethane (5 mL) was added bromotrimethylsilane (12.07 mg, 0.079 mmol), and the mixture stirred at room temperature overnight. The reaction was quenched with methanol, and the mixture was then stirred for 2 hours and concentrated. The residue was purified by preparative HPLC to give the titled compound (22.7 mg, 0.049 mmol, 61.9 % yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.33 - 7.01 (m, 5H), 6.54 (d, J = 22.4 Hz, 2H), 3.83 - 3.68 (m, 6H), 3.71 - 3.30 (m, 7H), 3.22 (s, 1H), 2.61 (s, 1H), 2.38 (s, 1H), 1.98 (s, 3H), 1.87 (s, 2H); MS (APCI ⁺ ) m/z 452.2 (M+H) ⁺ .

Example 51

N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycylgl ycine

[00609] Example 51 was prepared according to the procedure used for the preparation of Example 2, substituting methyl 2-aminoacetate for methyl 1-aminocyclohexanecarboxylate, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾ δ ppm 8.11 (s, 1H), 7.43 - 6.91 (m, 5H), 6.60 (s, 2H), 3.92 (s, 2H), 3.79 (d, / = 5.8 Hz, 2H), 3.74 (s, 6H), 3.14 (s, 4H), 2.00 (s, 3H), 1.86 (s, 2H); LC- MS (ESI+) m/z 429.2 (M+H) ⁺ , RT = 1.536 minutes. Example 52

2-benzyl-5 -[(3,5 -dimethoxy-4-methylbenzoyl)(3 -phenylpropyl) amino] pentanoic acid

[00610] Step 1 : methyl 2-benzyl-5-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] pentanoate

[00611] To a solution of methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] pentanoate (200 mg, 0.468 mmol, Example 4-Step 3) in tetrahydrofuran (10 mL) was added a solution of lithium diisopropylamide (55.1 mg, 0.515 mmol) in tetrahydrofuran at -78 °C. The mixture was stirred at -78 °C for 1 hour. Then a solution of benzyl bromide (0.056 mL, 0.468 mmol) in tetrahydrofuran (2 mL) was added to the mixture, and the mixture was stirred at -78 °C to room temperature overnight. Saturated NH ₄ C1 (5 mL) was added to the mixture, and the mixture was diluted with water (20 mL) and ethyl acetate (20 mL). The mixture was extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by preparative TLC to give the titled compound. LC-MS (ESI+) m/z 518 (M+H) ⁺ , RT = 2.26 minutes.

[00612] Step 2: 2-benzyl-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)a mino]pentanoic acid

[00613] To a solution of methyl 2-benzyl-5-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] pentanoate (30 mg, 0.058 mmol) in tetrahydrofuran (2 mL) was added aqueous lithium hydroxide solution (1.0 N, 1.0 mL). The mixture was stirred at room temperature for 2 hours. The mixture was acidified with 1 N hydrochloric acid to adjust pH = 3. The mixture was then extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue that was purified by preparative HPLC and lyophilized to give the titled compound. ¾ NMR (400 MHz, DMSO-<¾) δ ppm 7.19 (dq, / = 8.6, 8.0 Hz, 10H), 6.48 (s, 2H), 3.75 (s, 6H), 3.42 3.12 (m, 4H), 2.81 (t, / = 10.8 Hz, 1H), 2.65 (d, / = 13.8 Hz, 1H), 2.53 (s, 3H), 2.00 (s, 3H), 1.82 (d, / = 10.1 Hz, 2H), 1.68 1.22 (m, 4H); LC-MS (ESI+) nt/z 504 (M+H) ⁺ , RT = 2.11 minutes.

Example 53

{ 2- [(3 ,5 -dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino] ethanesulfinyl } acetic acid

[00614] ({2-[(3,5-Dimethoxy-4-methylbenzoyl)(3-phenylpropyl)arnino]e thyl}sulfanyl)acetic acid (20 mg, 0.046 mmol, Example 44) was dissolved in acetic acid (1 mL). The mixture was cooled to 5 °C, and hydrogen peroxide (1.576 mg, 0.046 mmol) was added. Then the mixture was stirred at room temperature for 3 hours. The reaction mixture was diluted with water and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated in vacuo to give a residue that was purified by preparative HPLC and lyophilized to give the titled compound. ^J H NMR (400 MHz, DMSO- ¾) δ ppm 7.17 - 7.03 (m, 5H), 6.53 (s, 2H), 3.93 (s, 2H), 3.74 (s, 6H), 3.64 (m, 2H), 3.21 (m, 2H), 3.11 (m, 1H), 2.63 (s, 1H), 2.45-2.38 (m, 2H), 1.98 (s, 3H), 1.85 (s, 2H); LC-MS (ESI+) mJz 448.2 (M+H) ⁺ , RT = 1.795 minutes.

Example 54

5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] -2-methylpentanoic acid

[00615] Step 1 : methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2- methylpentanoate

[00616] To a solution of diisopropylamine (1.467 mL, 10.29 mmol) in tetrahydrofuran (10 mL) was added «-butyllithium (10.29 mmol, 6.4 mL, 1.6 M in hexane) at 0 °C under a N ₂ atmosphere. The mixture was stirred at 0 °C for 0.5 hour, and then cooled to -78 °C. Then a solution of methyl 5- [(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pentan oate (2 g, 4.68 mmol, Example 4- Step 3) in tetrahydrofuran (10 mL) was added to the mixture dropwise, and the mixture was stirred at -78 °C for 10 minutes. Subsequently, methyl iodide (0.878 mL, 14.03 mmol) was added to the mixture, and the resultant mixture was stirred at -78 °C to room temperature for 2 hours. Then saturated NH ₄ C1 was added to the mixture, and the resultant mixture was extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to dryness. The residue was purified by flash chromatography on silica gel eluted with hexane and ethyl acetate to give the titled compound (1.74 g, 3.94 mmol, 84 % yield) that was used directly in the next step.

[00617] Step 2: 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2-m ethylpentanoic acid

To a solution of methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2- methylpentanoate (800mg, 1.812 mmol, Step 1) in tetrahydrofuran (6 mL) was added LiOH (8.15 mL, 8.15 mmol), and methanol (1 mL) was added to mix the layers. The reaction mixture was stirred at room temperature. Progress of the reaction was monitored by LC-MS ("TFA method"). After 3.5 hours, LC-MS indicated complete reaction. The reaction mixture was concentrated to remove volatiles. The residue was diluted with water, and this basic layer was acidified to pH~l with 1 N HCl. The aqueous mixture was then extracted with ethyl acetate. The organic layer was washed with brine, dried (MgS0 ₄ ) and concentrated. The residue was purified by flash chromatography on silica gel eluted with 0-100% ethyl acetate/heptanes gave the titled compound (0.75g, 97%). ¾ NMR (400 MHz, DMSO-<¾) δ ρρπι 11.85 (brs, 1H), 7.18 (dt, / = 34.8, 7.4 Hz, 5H), 6.49 (s, 2H), 3.75 (s, 6H), 3.14 (brs, 4H), 2.52-2.51 (m, 1H), 2.27 (s, 1H), 2.00 (s, 3H), 1.84 (t, / = 8.0 Hz, 2H), 1.52 (s, 3H), 1.24 (s, 1H), 1.02 (d, / = 7.0 Hz, 3H); LC-MS (ESI+) nt/z 428 (M+H) ⁺ , RT = 1.99 minutes.

Example 55

2-{2-[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethoxy } -2-methylpropanoic acid

[00618] Step 1 : methyl 2-(2,2-dimethoxyethoxy)-2-methylpropanoate [00619] To a mixture of sodium hydride (2.71 g, 67.7 mmol) in N,N-dimethylformamide (16 mL) was added methyl 2-hydroxy-2-methylpropanoate (4.00 g, 33.9 mmol) slowly over 5 minutes at room temperature. After addition, the mixture was stirred for 20 minutes. Then 2-bromo-l ,l - dimethoxy ethane (28.6 g, 169 mmol) was added dropwise to the mixture cooled in an ice-water bath. The reaction mixture was stirred at room temperature overnight. Then the mixture was poured into a vigorously stirred mixture of saturated aqueous ammonium chloride (50 mL) and ethyl

acetate/hexanes(l :3, 50 mL). Then the organic layer was separated, washed with water and brine once each, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated under vacuum at 70 °C to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-100%) to give the titled compound. H NMR (400 MHz, DMSO-<¾) δ ppm 4.52 (t, / = 5.2 Hz, 1H), 3.74 (s, 3H), 3.46 (d, / = 5.2 Hz, 2H), 3.40 (s, 6H), 1.44 (s, 6H).

[00620] Step 2: methyl 2-methyl-2-(2-oxoethoxy)propanoate

[00621] To a solution of methyl 2-(2,2-dimethoxyethoxy)-2-methylpropanoate (545 mg, 2.64 mmol) in CHC1 ₃ (5 mL) was added water (0.238 mL, 13.2 mmol) and trifluoroacetic acid (1.02 mL, 13.2 mmol), sequentially. The resulting mixture was stirred at room temperature overnight. Then the mixture was washed with water (5 mLx2) and saturated aqueous sodium bicarbonate solution (5 mL). The combined aqueous solution was extracted with dichloromethane (10 mLx2). The combined organic layers were washed with brine once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated in vacuo at 35 °C to give the titled compound. Ή NMR (400 MHz, DMSO-<¾) δ ppm 9.75 (t, / = 1.2 Hz, 1H), 4.05 (d, / = 1.2 Hz, 2H), 3.74 (s, 3H), 1.49 (s, 6H).

[00622] Step 3: methyl 2-methyl-2-{2-[(3-phenylpropyl)amino]ethoxy}propanoate

[00623] A solution of methyl 2-methyl-2-(2-oxoethoxy)propanoate (200 mg, 1.25 mmol) and 3- phenylpropan-1 -amine (169 mg, 1.25 mmol) in 1,2-dichloroethane (6 mL) was stirred at room temperature for 3 hours. Then 10% Pd/C (26.6 mg, 0.250 mmol) was added, and the mixture was stirred at room temperature for 1.5 hours under an atmosphere of hydrogen (balloon). Then additional Pd/C (26.6 mg, 0.250 mmol) was added, and the mixture was stirred for an additional 2 hours under a hydrogen balloon. The mixture was filtered, and the solids were washed with methanol. The filtrate was concentrated to provide the titled compound that was used directly in the next step without further purification. LC-MS (ESI+) m/z 280.2 (M+H) ⁺ , RT = 1.554 minutes.

[00624] Step 4: methyl 2-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)arnino] ethoxy}- 2-methylpropanoate

[00625] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (257 mg, 1.31 mmol) and 1- [bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (523 mg, 1.38 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.192 mL, 1.38 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then the mixture of methyl 2-methyl-2-{2-[(3-phenylpropyl)amino]ethoxy}propanoate from the previous step was added to the mixture in one portion. The mixture was stirred at room temperature for approximately 60 hours. The reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate (20 mLx3). The combined organic layers were washed with brine three times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-40%) to give the titled compound. LC-MS (ESI+) m/z 458.2 (M+H) ⁺ , RT = 2.139 minutes.

[00626] Step 5: 2-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]e thoxy}-2- methylpropanoic acid

[00627] To a solution of methyl 2-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy}-2-methylpropanoate (144 mg, 0.315 mmol) in dioxane (4 mL) was added aqueous lithium hydroxide solution.(1.0 N, 1.888 mL). The mixture was stirred at room temperature for 1 hour. The mixture was acidified with 1 N hydrochloric acid to adjust pH = 3 and then extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue that was purified by preparative HPLC and lyophilized to give the titled compound. ¾ NMR (400 MHz, DMSO-<¾ δ ppm 7.36 - 6.93 (m, 5H), 6.54 (s, 2H), 3.76 (s, 6H), 3.51 (s, 2H), 3.40 (s, 4H), 2.50 (s, 2H), 2.00 (s, 3H), 1.95 - 1.80 (m, 2H), 1.23 (s, 6H), T = 60 °C; LC-MS (ESI+) m/z 444.2 (M+H) ⁺ , RT = 1.991 minutes.

Example 56

3-{2-[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethoxy } propanoic acid

[00628] Step l : methyl 3-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy } propanoate

[00629] N-(2-Hydroxyethyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpropyl) benzamide (150 mg, 0.420 mmol, Example 6-Step 4) was added to a mixture of dry tetrahydrofuran (3 mL) and sodium hydride (30.2 mg, 1.259 mmol). The mixture was stirred for 20 minutes at room temperature. Then methyl acrylate (181 mg, 2.098 mmol) was added, and the resultant mixture was stirred for another 3 hours at ambient temperature. The mixture was poured into water, and the mixture was extracted with ethyl acetate three times. The combined organic layers were washed with brine, dried over sodium sulfate, and concentrated. The residue was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-50%) to give the titled compound. LC-MS (ESI+) m/z 444.5 (M+H) ⁺ , RT = 1.916 minutes.

[00630] Step 2: 3-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]e thoxy}propanoic acid

[00631] Methyl 3-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy} propanoate (25 mg, 0.056 mmol) was dissolved in tetrahydrofuran. 1 Ν Lithium hydroxide (6.75 mg, 0.282 mmol) solution was added, and then the mixture was stirred at room temperature for 3 hours. The mixture was acidified with 1 N hydrochloric acid to adjust the pH = 2-3. Then the mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated. The residue was purified by preparative HPLC and lyophilized to give the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 7.27 - 6.93 (m, 5H), 6.47 (s, 2H), 3.70 (s, 6H), 3.53 (t, / = 6.0 Hz, 2H), 3.47 (s, 2H), 3.40 (s, 2H), 2.43 (m, 4H), 2.36 (t, / = 6.2 Hz, 2H), 1.94 (s, 3H), 1.87 - 1.71 (m, 2H); LC-MS (ESI+) m/z 430.2 (M+H) ⁺ , RT = 1.644 minutes.

Example 57

5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] -2,2-dimethylpentanoic acid

[00632] Step 1 : methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2,2 - dimethylpentanoate

[00633] To a solution of diisopropylamine (0.267 mL, 1.87 mmol) in tetrahydrofuran (5 mL) was added «-butyllithium (1.87 mmol, 1.16 mL, 1.6 M in hexane) at 0 °C under a nitrogen atmosphere. The mixture was stirred at 0 °C for 0.5 hour, and cooled to -78 °C. Then a solution of methyl 5-[(3,5- dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2-methylpen tanoate (376 mg, 0.852 mmol, prepared as an intermediate for the preparation of Example 54 using the procedure described for Example 52) in tetrahydrofuran (5 mL) was added to the mixture dropwise, and the mixture was stirred at -78 °C for 1 hour. Then methyl iodide (0.160 mL, 2.55 mmol) was added to the mixture, and the mixture was stirred at -78 °C to room temperature for 2 hours. Then saturated NH ₄ C1 was added to quench the reaction, and the mixture was extracted with ethyl acetate (30 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated in vacuo to give a residue that was purified by chromatography on silica gel eluted with 0-50% ethyl acetate/hexanes to give the titled compound. LC-MS (ESI+) m/z 456 (M+H) ⁺ , RT = 2.20 minutes.

[00634] Step 2: 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2,2 - dimethylpentanoic acid

[00635] Methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2,2 - dimethylpentanoate (200 mg, 0.439 mmol) was dissolved in tetrahydrofuran (2 mL), and aqueous lithium hydroxide solution (1.3 mL, 1.31 mmol) was added. The mixture was stirred at room temperature for 12 hours. The mixture was acidified with 1 N hydrochloric acid to pH = 2-3. Then the mixture was extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue that was purified by preparative HPLC and lyophilized to give the titled compound. ¾ NMR (400 MHz, DMSO-<¾) δ ppm 7.45 - 6.84 (m, 5H), 6.50 (s, 2H), 3.76 (s, 6H), 3.40 (m, 2H), 3.15 (s, 2H), 2.64 (s, 1H), 2.41 (s, 1H), 2.00 (s, 3H), 1.85 (m, 1H), 1.80 (m, 1H), 1.48 (m, 3H), 1.25 (s, 1H), 1.10 (s, 3H), 1.02 (s, 3H); LC-MS (ESI+) m/z 442.3 (M+H) ⁺ , RT = 1.916 minutes. Example 58

5-[(2-fluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pent anoic acid

[00636] Example 58 was prepared according to the procedure used for the preparation of Example 4, substituting 2-fluoro-3,5-dimethoxybenzoic acid for 3,5-dimethoxy-4-methylbenzoic acid, to provide the titled compound. *H NMR (400 MHz, DMSO-<¾) δ ppm 12.02 (s, 1H), 7.19 (m, 4H), 6.98 (d, / = 7.3 Hz, 1H), 6.70 (dd, / = 21.7, 6.9 Hz, 1H), 6.31 (d, / = 12.6 Hz, 1H), 3.82 (d, / = 4.1 Hz, 3H), 3.72 (d, / = 7.3 Hz, 3H), 3.09 (m, 2H), 2.49 (s, 2H), 2.38 (t, / = 7.4 Hz, 1H), 2.05 (d, / = 5.7 Hz, 1H), 1.85 (m, 1H), 1.72 (t, / = 8.5 Hz, 1H), 1.49 (m, 3H), 1.26 (m, 1H); LC-MS (ESI+) mJz 418.2 (M+H) ⁺ , RT = 1.849 minutes.

Example 59

l-({2-[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethoxy } methyl)cyclopropane- 1 - carboxylic acid

[00637] Step 1 : ethyl l-(bromomethyl)cyclopropanecarboxylate

[00638] To the solution of ethyl l-(hydroxymethyl)cyclopropanecarboxylate (520 mg, 3.61 mmol) in dichloromethane (25 mL) was added triphenylphosphine (1.14 g, 4.33 mmol) and carbon tetrabromide (1.79 g, 5.41 mmol) sequentially under a N ₂ atmosphere. Then the solution was stirred at room temperature for 30 minutes, and then aqueous saturated NaHC0 ₃ was added to quench the reaction. The mixture was separated, and the organic layer was washed with brine once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated under vacuum to give a residue. The residue was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-20%) to give impure titled compound. The material was purified again by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-20%) to give the titled compound. 'H NMR (400 MHz, CDC1 ₃ ) δ ppm 4.19 (q, / = 7.1 Hz, 2H), 3.62 (s, 2H), 1.53 (dd, / = 5.2, 2.3 Hz, 2H), 1.28 (t, / = 7.1 Hz, 3H), 1.03 - 1.00 (m, 2H).

[00639] Step 2: l-({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy } methyl)cyclopropane- 1 -carboxylic acid

[00640] The titled compound was prepared according to the procedure used for the preparation of Example 6, substituting ethyl l-(bromomethyl)cyclopropanecarboxylate for methyl 2-chloroacetate. *H NMR (400 MHz, DMSO-<¾) δ ppm 12.40 (s, 1H), 7.33 - 6.99 (m, 5H), 6.52 (d, / = 24.5 Hz, 2H), 3.74 (s, 6H), 3.55 (s, 3H), 3.45 (s, 3H), 3.30 (s, 1H), 3.21 (s, 1H), 2.61 (s, 1H), 2.38 (s, 1H), 1.98 (s, 3H), 1.86 (d, / = 10.4 Hz, 2H), 0.91 (s, 2H), 0.64 (d, / = 17.4 Hz, 2H), T = 25 °C; LC-MS (ESI+) m/z 456.2 (M+H) ⁺ , RT = 1.958 minutes. Example 60

3-({2-[(3,5-dimethoxy-4-methylbenzoyl)(3^henylpropyl)amino]e thyl}sulfanyl)propanoic acid

[00641] Step 1 : N-(2-chloroethyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)b enzamide

[00642] To a solution of N-(2-hydroxyethyl)-3,5-dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide (100 mg, 0.280 mmol, Example 6-Step 4) in CH ₂ C1 ₂ (3 mL) was added diisopropylethylamine (0.147 mL, 0.839 mmol). The solution was cooled down to 0 °C followed by addition of methanesulfonyl chloride (0.044 mL, 0.560 mmol) in dichloromethane (0.5 mL) dropwise. After addition, the solution was stirred at room temperature for 1 hour. The solution was

concentrated, and the residue was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-60%) to give the titled compound. LC-MS (ESI+) m/z 376.2 (M+H) ⁺ , RT = 2.136 minutes.

[00643] Step 2: 5-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]e thyl} ethanethioate

[00644] To a solution of N-(2-chloroethyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)b enzamide (500 mg, 1.33 mmol) in N,N-dimethylformamide (10 mL) was added potassium ethanethioate (456 mg, 3.99 mmol) in one portion. Then the mixture was heated to 50 °C under a N ₂ atmosphere for 3 hours. The mixture was cooled down, diluted with water (30 mL), and extracted with ethyl acetate (20 mLx3). The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-60%) to give the titled compound. NMR (400 MHz, DMSO-<¾ 5 ppm 7.21 (d, / = 7.5 Hz, 2H), 7.13 (t, / = 7.3 Hz, 3H), 6.52 (s, 2H), 3.76 (s, 6H), 3.47 (s, 2H), 3.33 (s, 2H), 3.11 - 3.01 (m, 2H), 2.51 (d, / = 9.2 Hz, 2H), 2.30 (s, 3H), 2.00 (s, 3H), 1.86 (h, / = 6.7, 5.7 Hz, 2H), T = 60 °C; LC-MS (ESI+) m/z 416.2 (M+H) ⁺ , RT = 2.122 minutes.

[00645] Step 3: methyl 3-({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethyl } sulf anyl)propanoate

[00646] To a degassed solution of potassium hydroxide (27.0 mg, 0.481 mmol) in methanol (2 mL) was added 5-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]e thyl} ethanethioate (100 mg, 0.241 mmol), and the resulting mixture was stirred at 0 °C for 10 minutes under N ₂ . Then methyl 3-bromopropanoate (121 mg, 0.722 mmol) was added, and the mixture was heated to 50 °C for 2 hours. The mixture was concentrated giving a residue that was used directly in the next step. LC-MS (ESI+) m/z 460.2 (M+H) ⁺ , RT = 2.103 minutes.

[00647] Step 4: 3-({2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethyl } sulf any l)propanoic acid

[00648] Aqueous lithium hydroxide solution.(1.0 N, 1.45 mL) was added to a mixture of methyl 3- ({2-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)arnino]e thyl}sulfanyl)propanoate (111 mg, 0.241 mmol) in tetrahydrofuran (2 mL). The mixture was stirred at room temperature for 1 hour. The mixture was acidified with 1 N hydrochloric acid to adjust the pH = 2-3. The mixture was then extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue that was purified by preparative HPLC and lyophilized to give the titled compound. ¾ NMR (400 MHz, DMSO- ₆ ) δ ppm 12.24 (s, 1H), 7.32 - 6.99 (m, 5H), 6.52 (s, 2H), 3.74 (s, 6H), 3.53 (s, 1H), 3.43 (s, 1H), 3.32 (s, 1H), 3.19 (s, 1H), 2.73 (s, 2H), 2.64 (d, / = 10.2 Hz, 2H), 2.53 (s, 1H), 2.39 (s, 2H), 2.34 - 2.26 (m, 1H), 1.98 (s, 3H), 1.86 (d, / = 27.9 Hz, 2H), T = 25 °C; LC-MS (ESI+) m/z 446.2 (M+H) ⁺ , RT = 1.951 minutes.

Example 61

l-[({2-[(3,5 -dimethoxy-4-methylbenzoyl) (3 - phenylpropyl) amino] ethyl } sulf anyl)methyl] cyclopropane- 1 -carboxylic acid

[00649] The titled compound was prepared according to the procedure used for the preparation of Example 60, substituting ethyl l-(bromomethyl)cyclopropanecarboxylate for methyl 3- bromopropanoate. *H NMR (400 MHz, DMSO-<¾ δ ppm 11.94 (s, 1H), 7.32 - 7.05 (m, 5H), 6.53 (s, 2H), 3.76 (s, 6H), 3.44 (s, 2H), 3.33 (s, 2H), 2.81 - 2.60 (m, 4H), 2.53 (s, 2H), 2.00 (s, 3H), 1.92 - 1.79 (m, 2H), 1.10 (q, / = 3.9 Hz, 2H), 0.77 (s, 2H), T = 60 °C; LC-MS (ESI+) m/z 472.2 (M+H) ⁺ , RT = 2.002 minutes.

Example 62

3-({2-[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethyl } sulf anyl)butanoic acid

[00650] The titled compound was prepared according to the procedure used for the preparation of Example 60, substituting methyl 3-bromobutanoate for methyl 3-bromopropanoate. 'H NMR (400 MHz, DMSO-<¾ δ ppm 7.36 - 7.03 (m, 5H), 6.53 (s, 2H), 3.76 (s, 6H), 3.46 (s, 2H), 3.33 (s, 2H), 3.05 (s, 1H), 2.73 (s, 2H), 2.53 (s, 1H), 2.43 (s, 1H), 2.33 (s, 2H), 2.00 (s, 3H), 1.87 (d, / = 9.4 Hz, 2H), 1.20 (s, 3H), T = 60 °C; LC-MS (ESI+) m/z 460.2 (M+H) ⁺ , RT = 1.998 minutes.

Example 63

5-{ [l-(5-methoxypyridin-2-yl)cyclopropane-l-carbonyl](3-phenylp ropyl)amino}pentanoic acid

[00651] The titled compound was prepared according to the procedure used for the preparation of Example 4, substituting l-(5-methoxypyridin-2-yl)cyclopropanecarboxylic acid for 3,5-dimethoxy-4- methylbenzoic acid. *H NMR (400 MHz, DMSO-<¾) δ ppm 8.16 (dd, / = 4.8, 3.0 Hz, 1H), 7.35 - 7.00 (m, 6H), 6.97 (d, / = 7.3 Hz, 1H), 3.77 (d, / = 2.3 Hz, 3H), 3.31 - 3.13 (m, 5H), 2.55 (t, / = 7.8 Hz, 1H), 2.19 (dt, / = 25.5, 6.9 Hz, 2H), 1.94 (s, 1H), 1.77 (q, / = 7.8 Hz, 1H), 1.47 - 1.38 (m, 3H), 1.26 (q, / = 4.0, 3.4 Hz, 1H), 1.19 - 1.11 (m, 4H); LC-MS (ESI+) m/z 411 (M+H) ⁺ , RT = 1.677 minutes. Example 64

5- { (3 -phenylpropyl) [ 1 -(pyridin-4-yl)cyclopropane- 1 -carbonyl] amino jpentanoic acid

[00652] The titled compound was prepared according to the procedure used for the preparation of Example 4, substituting l-(pyridin-4-yl)cyclopropanecarboxylic acid for 3,5-dimethoxy-4- methylbenzoic acid. *H NMR (400 MHz, DMSO-<¾) δ ppm 8.47 - 8.39 (m, 2H), 7.33 - 7.11 (m, 4H), 7.12 - 6.89 (m, 3H), 3.31 - 3.19 (m, 2H), 3.09 (s, 2H), 2.54 (s, 1H), 2.28 (d, / = 7.3 Hz, 1H), 2.06 (s, 1H), 1.85 (s, 1H), 1.77 (s, 1H), 1.50 (d, / = 8.6 Hz, 1H), 1.46 - 1.34 (m, 2H), 1.24 (td, / = 27.6, 4.1 Hz, 5H), 1.07 - 1.00 (m, 1H); LC-MS (ESI+) m/z 381 (M+H) ⁺ , RT = 1.591 minutes.

Example 65

5-[(6-methoxy-lH-indole-3-carbonyl)(3-phenylpropyl)amino]pen tanoic acid

[00653] The titled compound was prepared according to the procedure used for the preparation of Example 4, substituting 6-methoxy-lH-indole-3-carboxylic acid for 3,5-dimethoxy-4-methylbenzoic acid. ^l U NMR (400 MHz, CD ₃ OD) δ ppm 7.51 (d, / = 8.8 Hz, 1H), 7.32 (s, 1H), 7.26 - 7.04 (m, 5H), 6.93 (d, / = 2.3 Hz, 1H), 6.78 (dd, / = 8.7, 2.3 Hz, 1H), 3.83 (s, 3H), 3.61 - 3.52 (m, 4H), 2.59 (s, 2H), 2.22 (s, 2H), 1.96 (s, 2H), 1.61 (d, J = 38.5 Hz, 4H); LC-MS (ESI+) m/z 409 (M+H) ⁺ , RT = 1.784 minutes.

Example 66

5-{ [(2R)-2-methoxy-2-(4-methoxyphenyl)acetyl](3-phenylpropyl)am ino}pentanoic acid

[00654] The titled compound was prepared according to the procedure used for the preparation of Example 4, substituting (5)-2-methoxy-2-(4-methoxyphenyl)acetic acid for 3,5-dimethoxy-4- methylbenzoic acid. *H NMR (400 MHz, DMSO-<¾) δ ppm 12.03 (s, 1H), 7.36 - 7.18 (m, 4H), 7.19 - 7.14 (m, 2H), 7.13 - 7.06 (m, 1H), 6.95 - 6.90 (m, 1H), 6.90 - 6.84 (m, 1H), 4.80 (s, 1H), 3.74 (s, 3H), 3.33 (m, 1H), 3.14 (s, 3H), 3.16 - 3.07 (m, 2H), 2.45 (m, 2H), 2.18 (dt, / = 13.4, 6.9 Hz, 2H), 1.71 (q, / = 7.3 Hz, 2H), 1.50 - 1.33 (m, 3H); LC-MS (ESI+) m/z 414.2 (M+H) ⁺ , RT = 1.825 minutes.

Example 67

N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)-beta-al anine

[00655] Step 1 : methyl 3-[(3-phenylpropyl)amino]propanoate

[00656] A solution of 3-phenylpropan-l-amine (500 mg, 3.70 mmol) and methyl acrylate (500 μL· 5.55 mmol) was heated to reflux at 90 °C for 1 hour. The mixture was cooled down and purified (loaded directly with CH ₂ C1 ₂ ) by flash column chromatography (eluent: CH ₂ C1 ₂ /CH ₃ OH=0~20%) to give the titled compound (668 mg, 3.02 mmol, 82% yield). LC-MS (ESI+) m/z 222.2 (M+H) ⁺ , RT = 1.400 minutes.

[00657] Step 2: methyl 3-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]prop anoate [00658] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (380 mg, 1.937 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (773 mg, 2.033 mmol, HATU) in N,N-dimethylformamide (8 mL) was added triethylamine (0.283 mL 2.033 mmol). The resulting solution was stirred at room temperature for 5 minutes. Then Example 67-Step 1 (450 mg, 2.033 mmol) was added in one portion. The solution was stirred at room temperature for 3 hours. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-100%) to give the titled compound (593 mg, 1.484 mmol, 77% yield). LC-MS (ESI+) nt/z 400.2 (M+H) ⁺ , RT = 1.990 minutes.

[00659] Step 3: N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)-beta-al anine

[00660] To a solution of Example 67-Step 2 (593 mg, 1.484 mmol) in methanol (10 mL) was added 1 Ν lithium hydroxide (8.91 mL 8.91 mmol). The resulting mixture was stirred at room temperature overnight and then concentrated under reduced pressure. The resultant mixture was acidified with 1 Ν HC1 to pH=2~3. The solid precipitate was extracted with ethyl acetate 3 times. The organic layers were combined and washed with brine once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (562 mg, 1.458 mmol, 98% yield). *H NMR (400 MHz, DMSO-i¾) δ ppm 12.30 (s, 1H), 7.17 (s, 4H), 7.03 (s, 1H), 6.52 (s, 2H), 3.74 (s, 6H), 3.57 (s, 1H), 3.41 (s, 2H), 3.19 (s, 1H), 2.54 (s, 4H), 1.98 (s, 3H), 1.83 (s, 2H); LC-MS (ESI+) m/z 386.2 (M+H) ⁺ , RT = 1.856 minutes.

Example 68

3 , 5 -dimethoxy-4-methyl-N- { 3 - [(methylsulf amoyl)amino] -3 -oxopropyl } -N-(3 - phenylpropyl)benzamide

[00661] Example 67 (100 mg, 0.259 mmol) was dissolved in tetrahydrofuran (4 mL) and carbonyldiimidazole (63.1 mg, 0.389 mmol) was added. The mixture was heated to 60 °C for 1 hour. More carbonyldiimidazole (63.1 mg, 0.389 mmol) was added, and the resultant solution was stirred at 60 °C for 1 hour. The solution was cooled down to room temperature and was then added dropwise through a syringe to a solution of l,8-diazabicyclo[5.4.0]undec-7-ene (0.117 mL 0.778 mmol, DBU) and N-methylsulfuric diamide (86 mg, 0.778 mmol) in 0.6 mL tetrahydrofuran. The resulting mixture was stirred at room temperature overnight. The mixture was acidified with 1 Ν HC1 to pH=6~7 and then extracted with ethyl acetate 3 times. The organic layers were combined and concentrated. The residue was diluted with methanol to give a solution which was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (72.5 mg, 0.152 mmol, 58.5% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 11.39 (s, 1H), 7.46 (q, J = 4.9, 4.5 Hz, 1H), 7.14 (dd, J = 56.8, 38.2 Hz, 5H), 6.50 (s, 2H), 3.74 (s, 6H), 3.67 - 3.58 (m, 1H), 3.46 (d, J = 19.0 Hz, 4H), 3.19 (s, 1H), 2.60 (s, 3H), 2.40 (s, 2H), 1.98 (s, 3H), 1.82 (d, J = 16.8 Hz, 2H); LC-MS (ESI+) m/z 478.2 (M+H) ⁺ , RT = 1.919 minutes.

Example 69

4- [(3 ,5 -dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino] butanoic acid

[00662] Step 1 : methyl (2£T)-4-[(3-phenylpropyl)amino]but-2-enoate

[00663] A mixture of (£T)-methyl 4-bromobut-2-enoate (300 mg, 1.676 mmol), 3-phenylpropan-l- amine (227 mg, 1.676 mmol) and potassium carbonate (463 mg, 3.35 mmol) in CH ₃ CN (5 mL) was stirred at room temperature for 1.5 hours. The mixture was concentrated to give the titled compound which was used directly in the next step. LC-MS (ESI+) m/z 234.2 (M+H) ⁺ , RT = 1.470 minutes.

[00664] Step 2: methyl (2£T)-4-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)ami no]but-2- enoate

[00665] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (329 mg, 1.676 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (669 mg, 1.760 mmol, HATU) in N,N-dimethylformamide (6 mL) was added triethylamine (0.245 mL 1.760 mmol). The resulting solution was stirred at room temperature for 5 minutes. Then a solution of Example 69-Step 1 in N,N-dimethylformamide (2.0 mL) was added in one portion. The solution was stirred at room temperature for 30 minutes. The mixture was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (230 mg, 0.257 mmol, 15.31% yield). LC-MS (ESI+) m/z 412.2 (M+H) ⁺ , RT = 2.060 minutes.

[00666] Step 3: (2£T)-4-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)ami no]but-2-enoic acid

[00667] To a solution of Example 69-Step 2 (230 mg, 0.559 mmol) in 1,4-dioxane (5 mL) was added 1 N lithium hydroxide (2.236 mL 2.236 mmol). The solution was heated to 50 °C for 3 hours. The reaction mixture was acidified with 1 N HCl to pH=2-3. It was extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue which was purified twice by preparative HPLC (0.1% CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (27 mg, 0.068 mmol, 12.15% yield). *H NMR (400 MHz, DMSO-<¾ δ ppm 12.17 (s, 1H), 7.36 - 6.98 (m, 5H), 6.76 (d, J = 15.4 Hz, 1H), 6.55 (s, 2H), 5.87 (d, J = 15.8 Hz, 1H), 4.11 (s, 2H), 3.75 (s, 6H), 3.30 (s, 2H), 2.50 (s, 2H), 2.00 (s, 3H), 1.95 - 1.76 (m, 2H); LC-MS (ESI) m/z 398.2 (M+H) ⁺ , RT = 1.889 minutes.

[00668] Step 4: 4-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]buta noic acid

[00669] To a solution of Example 69-Step 3 (111 mg, 0.280 mmol) in CH ₃ OH (5 mL) was added palladium on carbon (2.98 mg, 0.028 mmol). The mixture was stirred at room temperature under a hydrogen atmosphere (balloon) for 1 hour. The reaction mixture was filtered. The filtrate was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (43.7 mg, 0.109 mmol, 39.1% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.17 (dt, J = 34.6, 8.0 Hz, 5H), 6.51 (s, 2H), 3.76 (s, 6H), 3.31 (s, 4H), 2.50 (s, 2H), 2.17 (d, J = 7.9 Hz, 2H), 2.00 (s, 3H), 1.94 - 1.68 (m, 4H); LC-MS (ESI) m/z 400.2 (M+H) ⁺ , RT = 1.914 minutes.

Example 70

3,5-dimethoxy-4-methyl-N-{5-[(methylsulfamoyl)amino]-5-oxope ntyl}-N-(3- phenylpropyl)benzamide

[00670] Step 1 : methyl 5-[(3-phenylpropyl)amino]pentanoate

[00671] A mixture of methyl 5-bromopentanoate (200 mg, 1.025 mmol), 3-phenylpropan-l -amine (139 mg, 1.025 mmol) and potassium carbonate (170 mg, 1.230 mmol) in CH ₃ CN (4 mL) was stirred at room temperature for 1.5 hours and then heated to reflux for 1 hour. The mixture was cooled down and filtered to give the titled compound which was used without further purification in the next step. LC-MS (ESI) m/z 250.2 (M+H) ⁺ , RT = 1.515 minutes.

[00672] Step 2: methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoate

[00673] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (201 mg, 1.025 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (409 mg, 1.076 mmol, HATU) in N,N-dimethylformamide (6 mL) was added triethylamine (0.150 mL 1.076 mmol). The resulting solution was stirred at room temperature for 5 minutes. Then a solution of Example 70-Step 1 in N,N-dimethylformamide (2.0 mL) was added in one portion. The solution was stirred at room temperature for 1 hour. The mixture was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (10-70%) to give the titled compound (136 mg, 0.318 mmol, 31.0% yield). LC-MS (ESI) m/z 428.2 (M+H) ⁺ , RT = 2.104 minutes.

[00674] Step 3: 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid

[00675] To a solution of Example 70-Step 2 (136 mg, 0.318 mmol) in 1,4-dioxane (4 mL) was added 1 N lithium hydroxide (1.909 mL 1.909 mmol). The solution was heated to 50 °C for 1.5 hours. The solution was acidified with 1 N HC1 to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (118 mg, 0.286 mmol, 44.9% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.18 (dt, J = 34.8, 7.6 Hz, 5H), 6.49 (s, 2H), 3.76 (s, 6H), 3.29 (s, 4H), 2.50 (s, 2H), 2.17 (s, 2H), 2.00 (s, 3H), 1.95 - 1.76 (m, 2H), 1.54 (d, J = 8.7 Hz, 2H), 1.44 (s, 2H); LC-MS (ESI) m/z 414.2 (M+H) ⁺ , RT = 1.943 minutes. [00676] Step 4: 3,5-dimethoxy-4-methyl-N-{5-[(methylsulfamoyl)amino]-5-oxope ntyl}-N-(3- phenylpropyl)benzamide

[00677] Material from Example 70-Step 3 (59 mg, 0.143 mmol) was dissolved in tetrahydrofuran (4 mL), and carbonyldiimidazole (69.4 mg, 0.428 mmol) was added. The mixture was heated to 60 °C for 40 minutes. Additional carbonyldiimidazole (69.4 mg, 0.428 mmol) was added with continued stirring for 1 hour. N-Methylsulfuric diamide (47.1 mg, 0.428 mmol) and 1,8- diazabicyclo[5.4.0]undec-7-ene (0.065 mL 0.428 mmol, DBU) were added after the mixture was cooled down to room temperature, and the solution was stirred overnight at room temperature. The solution was acidified with 1 Ν HCl to pH=2~3 and extracted with ethyl acetate twice. The organic layers were combined and concentrated to give a residue which was purified by preparative HPLC (neutral phase, H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (44.2 mg, 0.087 mmol, 61.3% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 11.06 (s, 1H), 7.40 - 6.91 (m, 6H), 6.49 (s, 2H), 3.76 (s, 6H), 3.29 (s, 4H), 2.51 (s, 2H), 2.48 (dd, J = 2.1, 1.5 Hz, 3H), 2.23 (d, J = 7.7 Hz, 2H), 2.00 (s, 3H), 1.94 - 1.76 (m, 2H), 1.52 (d, J = 8.7 Hz, 4H); LC-MS (ESI) m/z 506.2 (M+H) ⁺ , RT = 1.941 minutes.

Example 71

{ 4- [(3 , 5 -dimethoxy-4-methylbenzoyl)(3 -phenylpropyl)amino] butyl } phosphonic acid

and

Example 72

{5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)arnino]pe ntan-2-yl}phosphonic acid

[00678] Step 1 : diethyl {4-[(3-phenylpropyl)amino]butyl}phosphonate

[00679] To a solution of diethyl (4-iodobutyl)phosphonate (2.0 g, 3.12 mmol) in tetrahydrofuran (10 mL) was added diisopropylethylamine (1.091 mL, 6.25 mmol) and 3-phenylpropan-l-amine (0.845 g, 6.25 mmol). The mixture was stirred at 70 °C under a nitrogen atmosphere for 1 hour. The solution was poured into water (10 mL), extracted with ethyl acetate (10 mL x 3) and concentrated. The residue was purified by preparative-HPLC to the titled compound (600 mg, 1.833 mmol, 58.7 % yield). *H NMR (400 MHz, CDC1 ₃ ) δ ppm 9.32 (s, 2H), 7.29 (dt, J = 6.7, 1.3 Hz, 2H), 7.24 - 7.12 (m, 3H), 4.15 - 3.99 (m, 4H), 3.00 - 2.86 (m, 4H), 2.68 (t, J = 7.6 Hz, 2H), 2.10 (p, J = 7.6 Hz, 2H), 1.87 (t, J = 7.4 Hz, 2H), 1.66 (d, J = 7.6 Hz, 4H), 1.32 (q, J = 7.0 Hz, 6H); MS (APCI ⁺ ) m/z 328.2 (M+H) ⁺ .

[00680] Step 2: diethyl {4-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] butyl } phosphonate

[00681] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (1.226 g, 6.25 mmol) in

dichloromethane (40 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (2.376 g, 6.25 mmol, HATU) and diisopropylethylamine (2.183 mL, 12.50 mmol). The mixture was stirred at 25 °C under a nitrogen atmosphere for 1 hour. To this solution was added diethyl {4-[(3-phenylpropyl)amino]butyl}phosphonate (2.046 g, 6.25 mmol, Step 1), and the mixture was stirred for another 2 hours. The solution was poured into water (30 mL), extracted with ethyl acetate (40 mL x 3) and concentrated. Flash chromatography on silica gel (50-100% ethyl acetate in «-hexane) gave the titled compound (2.4 g, 4.75 mmol, 76 % yield). MS (APCI ⁺ ) m/z 506.6 (M+H) ⁺ .

[00682] Step 3: diethyl {5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pen tan-2- yl} phosphonate and diethyl {4-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] butyl } phosphonate

[00683] To a solution of diethyl {4-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] butyl} phosphonate (250 mg, 0.494 mmol, Step 2) in tetrahydrofuran (30 mL) was added 1 M lithium diisopropylamide (1.483 mL, 1.483 mmol; tetrahydrofuran/hexanes, 1 :7) dropwise at -78 °C. The mixture was stirred at -78 °C for 1 hour. To the mixture was added methyl iodide (0.093 mL, 1.483 mmol), and the resulting mixture was stirred at -78 °C under a nitrogen atmosphere for 2 hours. The reaction was quenched with aqueous NH ₄ C1. Then the mixture was poured into water (30 mL), extracted with ethyl acetate (30 mL x 3) and concentrated. Flash chromatography (5-40% ethyl acetate in «-hexane followed by 2-7% methanol in dichloromethane) gave a mixture of diethyl {5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pen tan-2- yljphosphonate (200 mg, 0.192 mmol, 38.9 % yield) MS (APCI ⁺ ) m/z 520.6 (M+H) ⁺ and diethyl {4- [(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]butyl} phosphonate (200 mg, 0.119 mmol, 24.00 % yield) MS (APCI ⁺ ) m/z 506.6 (M+H) ⁺ that was used directly in the next step.

[00684] Step 4: {4-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)arnino]bu tyl}phosphonic acid and {5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pen tan-2-yl}phosphonic acid

[00685] To a solution of diethyl {4-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] butyl} phosphonate (200 mg, 0.119 mmol) and diethyl {5-[(3,5-dimethoxy-4- methylbenzoyl)(3-phenylpropyl)amino]pentan-2-yl}phosphonate (200 mg, 0.192 mmol) in dichloromethane (10 mL) was added bromotrimethylsilane (459 mg, 3.0 mmol) dropwise at room temperature, and the resulting mixture was stirred overnight. To the mixture was added 5 mL of methanol and 0.5 mL of 28% ammonia in water, and the mixture was stirred for another 10 minutes. The mixture was concentrated, and the residue was purified by preparative -HPLC to give {4-[(3,5- dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]butyl}phosph onic acid (21.6 mg, 0.047 mmol, 15.70 % yield); *H NMR (400 MHz, DMSO-<¾) δ ppm 7.03-7.26 (5H, m, br), 6.48 (2H, s), 3.74 (6H, s), 3.38 (2H, s, br), 3.15 (2H, s, br), 2.61 (IH, s, br), 2.39 (IH, s, br), 1.98 (3H, s), 1.22-1.89 (6H, m), MS (APCI ⁺ ) m/z 450.5 (M+H) ⁺ and then {5-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] pentan-2-yl}phosphonic acid (17.2 mg, 0.036 mmol, 11.87 % yield); ¾ NMR (400 MHz, methonol-<¾ δ ppm 6.96-7.30 (5H, m), 6.47-6.64 (2H, m), 3.77-3.82 (6H, m), 3.51 (2H, s, br), 3.30 (3H, m), 3.28 (2H, m), 2.69 (1H, m), 2.45 (1H, m), 2.05 (3H, s), 1.03-1.89 (5H, m), MS (APCI ⁺ ) m/z 464.5 (M+H) ⁺ .

Example 73

1 -(4-methoxyphenyl) -N- { 5 - [(methylsulf amoyl) amino] -5 -oxopentyl } -N-(3 - phenylpropyl)cyclopropane- 1 -carboxamide

[00686] Step 1 : 5-{ [l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid

[00687] l-(4-Methoxyphenyl)cyclopropanecarboxylic acid (100 mg, 0.521 mmol) and 1- [bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (238 mg, 0.626 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (270 mg, 2.085 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 70-Step 1 (130 mg, 0.521 mmol) was added, and the solution was stirred overnight at room temperature. Then the mixture was poured into aqueous NH ₄ C1 and extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine dried over Na ₂ S0 ₄ , and concentrated. The residue was re-dissolved in

tetrahydrofuran, and treated with 1 N LiOH for 2 hours. The mixture was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (63 mg, 0.154 mmol, 29.5% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.26 (t, J = 7.6 Hz, 2H), 7.19 (d, J = 7.8 Hz, 2H), 7.10 (d, J = 7.9 Hz, 1H), 7.01 (dd, J = 14.0, 7.9 Hz, 2H), 6.86 (t, J = 6.4 Hz, 2H), 3.72 (s, 4H), 2.27 (d, J = 8.1 Hz, 1H), 2.21 (s, 1H), 2.01 (s, 1H), 1.73 (s, 1H), 1.42 (s, 3H), 1.35 (s, 1H), 1.18 (s, 2H), 1.10 (d, J = 23.5 Hz, 3H), 0.93 (d, J = 5.2 Hz, 1H).

[00688] Step 2: l-(4-methoxyphenyl)-N-{ 5-[(methylsulfamoyl)amino]-5-oxopentyl}-N-(3- phenylpropyl)cyclopropane- 1 -carboxamide

[00689] Material from Example 73-Step 1 (40 mg, 0.098 mmol) was dissolved in tetrahydrofuran (5 mL) and l ,l'-carbonyldiimidazole (47.5 mg, 0.293 mmol) was added. The mixture was heated to 60 °C for 1 hour, then l ,8-diazabicyclo[5.4.0]undec-7-ene (44.6 mg, 0.293 mmol) and N- methylsulfuric diamide (32.3 mg, 0.293 mmol) were added followed by stirring at room temperature for 12 hours. The mixture was concentrated, and the residue was dissolved in CH ₃ OH (1.3 mL) to which a couple of drops of acetic acid were added to adjust the pH to 6-7. The filtered solution was purified by preparative HPLC (0.1 % CF ₃ CO ₂ H/H ₂ O/CH ₃ CN) to give the titled compound (28 mg, 0.056 mmol, 57.1 % yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 11.25 (s, 1H), 7.42 - 7.36 (m, 1H), 7.33 - 7.08 (m, 4H), 7.06 - 6.96 (m, 2H), 6.86 (d, J = 7.6 Hz, 2H), 3.73 (s, 2H), 3.26 - 3.16 (m, 3H), 2.46 (s, 2H), 2.32 - 2.20 (m, 2H), 2.09 (t, J = 7.2 Hz, 1H), 1.73 (s, OH), 1.43 (s, 2H), 1.34 (s, 1H), 1.30 - 1.21 (m, 1H), 1.18 (s, 1H), 1.13 (s, 1H), 1.07 (s, 1H), 0.93 (s, 1H). Example 74

3 , 5 -dimethoxy-N- { 5 - [(methylsulf amoyl)amino] -5 -oxopentyl } -N-(3 -phenylpropyl)benzamide

[00690] Step 1 : methyl 5-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pentanoate

[00691] 3,5-Dimethoxybenzoic acid (100 mg, 0.549 mmol) and l-[bis(dimethylamino)methylene]- lH-l,2,3-triazolo[4,5- ?]pyridinium 3-oxid hexafluorophosphate (250 mg, 0.659 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N- diisopropylethylamine (213 mg, 1.647 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 70-Step 1 (137 mg, 0.549 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (160 mg, 0.387 mmol, 70.5% yield).

[00692] Step 2: 5-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pentanoic acid

[00693] Step 1 (80 mg, 0.193 mmol) was dissolved in tetrahydrofuran (2 mL) and CH ₃ OH (0.2 mL), and then 1 N LiOH (1.0 mL) was added. The mixture was stirred at room temperature for 3 hours and then concentrated. The residue was treated with water (5 mL) followed by the addition of 1 N hydrochloric acid to adjust the pH to 5, and then the aqueous phase was extracted with ethyl acetate. The organic layer was washed with brine, dried, and concentrated. The residue was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H) to provide the titled compound (50 mg, 0.125 mmol, 64.7% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.23 (d, J = 31.8 Hz, 4H), 7.05 (d, J = 5.7 Hz, 1H), 6.51 (s, 1H), 6.40 (s, 2H), 3.75 (s, 6H), 3.14 (s, 3H), 2.62 (s, 1H), 2.23 (s, 1H), 2.05 (s, 1H), 1.83 (d, J = 36.0 Hz, 3H), 1.53 (m, 4H), 1.26 (d, J = 14.8 Hz, 2H); LC-MS (ESI) m/z 400.2 (M+H) ⁺ .

[00694] Step 3: 3,5-dimethoxy-N-{ 5-[(methylsulfamoyl)amino]-5-oxopentyl}-N-(3- phenylpropyl)benzamide

[00695] The material from Example 74-Step 2 (40 mg, 0.100 mmol) was dissolved in

tetrahydrofuran (5 mL), and l,l'-carbonyldiimidazole (48.7 mg, 0.300 mmol) was added. The mixture was heated to 60 °C for 1 hour, and then l,8-diazabicyclo[5.4.0]undec-7-ene (45.7 mg, 0.300 mmol) and N-methyl sulfonamide (33.1 mg, 0.300 mmol) were added followed by stirring at room temperature for 12 hours. The mixture was concentrated, and the residue was dissolved in CH ₃ OH (1.3 mL) to which a couple drops of acetic acid were added to adjust the pH to 6-7. The filtered solution was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H/H ₂ 0/CH ₃ CN) to give the titled compound (26 mg, 0.053 mmol, 52.8% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 11.26 (d, J = 16.9 Hz, 2H), 7.40 (d, J = 5.9 Hz, 2H), 7.34 - 7.11 (m, 8H), 7.05 (d, J = 7.3 Hz, 2H), 6.52 (s, 2H), 6.40 (s, 4H), 3.75 (s, 11H), 3.19 - 3.11 (m, 3H), 2.67 - 2.58 (m, 2H), 2.44 (dt, J = 30.5, 6.4 Hz, 11H), 2.30 (s, 2H), 2.15 (s, IH), 1.88 (s, IH), 1.79 (s, IH), 1.55 (s, 3H), 1.46 (s, IH), 1.32 (s, IH); LC-MS (ESI) m/z 492.2 (M+H) ⁺ .

Example 75

{ 4- [(3 , 5 -dimethoxybenzoyl) (3 -phenylpropyl)amino] butyl } phosphonic acid and

Example 76

ethyl hydrogen { 4- [(3 , 5 -dimethoxybenzoyl)(3 -phenylpropyl) amino] butyl } phosphonate

[00696] Step 1 : diethyl {4-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]butyl}phosph onate

[00697] To a stirred solution of 3,5-dimethoxybenzoic acid (107 mg, 0.589 mmol) in

dichloromethane (2 mL) was added l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5- Z?]pyridinium 3-oxid hexafluorophosphate (224 mg, 0.589 mmol, HATU), diisopropylethylamine (0.317 mL, 1.812 mmol) and diethyl {4-[(3-phenylpropyl)amino]butyl}phosphonate (200 mg, 0.453 mmol, Example 71/72-Step 1) at room temperature, and the resulting mixture was stirred overnight. The solution was poured into water (-20 mL), extracted with ethyl acetate (2x20 mL) and concentrated. Preparative-HPLC gave the titled compound (202 mg, 0.390 mmol, 86 % yield). Ή NMR (400 MHz, DMSO-<¾) δ ppm 7.34 - 6.98 (m, 5H), 6.56 - 6.43 (m, IH), 6.42 - 6.30 (m, 2H), 3.93 (s, 4H), 3.39 (s, 2H), 3.13 (s, 2H), 2.61 (s, IH), 2.38 (s, IH), 1.77 (s, 3H), 1.56 (d, J = 36.2 Hz, 4H), 1.32 - 1.09 (m, 7H); MS (APCI ⁺ ) m/z 492.2 (M+H) ⁺ .

[00698] Step 2: {4-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]butyl}phosph onic acid and ethyl hydrogen { 4- [(3 , 5 -dime thoxybenzoyl)(3 -phenylpropyl) amino] butyl } phosphonate

[00699] To a solution of diethyl {4-[(3,5-dimethoxybenzoyl)(3- phenylpropyl) amino] butyl} phosphonate (175 mg, 0.356 mmol) in dichloromethane (10 mL) was added bromotrimethylsilane (545 mg, 3.56 mmol) at 0 °C. The mixture was stirred at 0 °C under a nitrogen atmosphere for 16 hours, and then it was warmed to room temperature with stirring continued for an additional 3 hours. To the reaction mixture was added methanol (10 mL) and 28% ammonia (0.5 mL), and resultant mixture was concentrated. Preparative-HPLC gave {4-[(3,5- dimethoxybenzoyl)(3-phenylpropyl)amino]butyl}phosphonic acid (51.9 mg, 0.117 mmol, 32.8 % yield), *H NMR (400 MHz, DMSO-<¾) δ ppm 7.29 - 7.02 (m, 5H), 6.49 (s, IH), 6.38 (d, J = 8.2 Hz, 2H), 3.73 (s, 6H), 3.12 (s, 2H), 2.60 (d, J = 8.2 Hz, IH), 2.38 (s, IH), 1.81 (d, J = 35.0 Hz, 2H), 1.55 (d, J = 39.8 Hz, 4H), 1.38 - 1.21 (m, 2H), m/z 436.4 (M+H) ⁺ ; and then ethyl hydrogen {4-[(3,5- dimethoxybenzoyl)(3-phenylpropyl)amino]butyl}phosphonate (87.5 mg, 0.185 mmol, 52.0 % yield), *H NMR (400 MHz, DMSO-<¾) δ ppm 7.30 - 7.02 (m, 5H), 6.50 (s, IH), 6.38 (d, J = 7.2 Hz, 2H), 3.87 (d, J = 20.7 Hz, 2H), 3.73 (s, 6H), 3.38 (s, 2H), 3.12 (d, J = 7.8 Hz, 2H), 2.61 (s, IH), 2.38 (s, IH), 1.77 (s, 2H), 1.60 (s, 5H), 1.30 - 1.11 (m, 4H), MS (APCI ⁺ ) m/z 464.46 (M+H) ⁺ . Example 77

(-) -(2R) -5 - [(3 , 5 -dimethoxy-4-methylbenzoyl)(3 -phenylpropyl) amino] -2-methylpentanoic acid

[00700] Step 1 : benzyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2- methylpentanoate

[00701] Thionyl chloride (40 mL, 548 mmol) was added to 5-[(3,5-dimethoxy-4- methylbenzoyl)(3-phenylpropyl)amino]-2-methylpentanoic acid (Example 54, 10.0 g, 23.39 mmol), and the resulting solution was heated at 75 °C for 2.5 hours. The solution was cooled to room temperature and concentrated under vacuum. The residue was dissolved in CH ₂ C1 ₂ (40 mL) and concentrated again to remove excess SOCl ₂ . Finally, the crude acid chloride was dissolved in CH ₂ C1 ₂ (40 mL) and stirred with ice cooling. Pyridine (5.68 mL, 70.2 mmol) was added, followed by benzyl alcohol (4.86 mL, 46.8 mmol). The cold bath was removed, and the resulting mixture was allowed to stir at room temperature for 12 hours. The reaction solution was diluted with CH ₂ C1 ₂ (60 mL) and washed successively with 8% aqueous H ₂ S0 ₄ (80 mL) and 20% aqueous K ₂ C0 ₃ (40 mL). The organic phase was dried over Na ₂ S0 ₄ and concentrated under vacuum. The residue was purified by flash chromatography (120 g silica cartridge eluted with heptanes-ethyl acetate, 95:5 - 65:35) to provide the titled compound (9.52 g). Thin-layer chromatography R _f -0.42 in heptanes-ethyl acetate, 67:33; MS (ESI+) m/z 518 (M+H) ⁺ .

[00702] Step 2: benzyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2- methylpentanoate - isomer 1 and isomer 2

[00703] Benzyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2-m ethylpentanoate was separated into the individual enantiomers by preparative chiral HPLC, using a 30 mm ID x 250 mm Chiralcel® OJ-H column and the following elution parameters: Mobile phase: A: Hexanes; B:

Methanol-isopropanol (80:20)

Isocratic elution A/B = 30:70 at 30 mL/minute

Detection: UV at 254 nm

Sample loading (each injection): 159 mg in methanol (1 mL)

[00704] The fractions eluting at 6.2-7.9 minutes were pooled and concentrated to give benzyl 5- [(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2-met hylpentanoate - isomer 1, 3.90 g.

[00705] The fractions eluting at 9-13.2 minutes were pooled and concentrated to give benzyl 5- [(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2-met hylpentanoate - isomer 2, 2.82 g.

[00706] Step 3: (-)-(2R)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)a mino]-2- methylpentanoic acid

[00707] Benzyl 5-(3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)benzamido)-2-met hylpentanoate (Step 2-isomer 1, 3.89 g) was dissolved in tetrahydrofuran (120 mL). 20% Pd(OH) ₂ /C (wet, 6.23 g) was added, and the mixture was agitated on a Parr shaker under H ₂ (50 psi) for 50 hours until debenzylation was complete. The mixture was filtered through a polypropylene membrane, and the filtrate was concentrated under vacuum. The residue was purified by flash chromatography (80 g silica eluted with CH ₂ C1 ₂ -CH ₃ 0H, 99: 1 - 95:5) to provide a gum which was solidified from heptanes- ethyl acetate (8 mL, 60:40) to provide the titled compound (1.4 g). *H NMR (400 MHz, DMSO-<¾, T = 120 °C) 5 ppm 7.28 -7.18 (m, 2H), 7.16-7.06 (m, 3H), 6.50 (s, 2H), 3.76 (s, 6H), 3.36-3.27 (m, 4H), 2.54 (t, J = 7.5 Hz, 2H), 2.29 (q, J = 7.0 Hz, 1H), 2.02 (s, 3H), 1.87 (p, J = 7.5 Hz, 2H), 1.67-1.43 (m, 3H), 1.42-1.19 (m, 1H), 1.04 (d, J = 7.0 Hz, 3H); MS (APCI) m/z 428 (M+H) ⁺ ; [a] _D ^{22 1} = -6.7, c = 1 (CH ₃ OH); Analytical chiral HPLC elution 4.084 minutes.

Example 78

(+)-(25)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)a mino]-2-methylpentanoic acid

[00708] The title compound was prepared by a procedure similar to that described for Example 77, but starting with benzyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2- methylpentanoate Example 77-Step 2-isomer 2. Ή NMR (400 MHz, DMSO-<¾, T = 120 °C) δ ppm 7.25-7.16 (m, 2H), 7.12 (t, J = 6.1 Hz, 3H), 6.50 (s, 2H), 3.76 (s, 6H), 3.37-3.23 (m, 4H), 2.54 (t, J = 7.6 Hz, 2H), 2.36-2.22 (m, 1H), 2.02 (s, 3H), 1.86 (p, J = 7.7 Hz, 2H), 1.62-1.47 (m, 3H), 1.37-1.20 (m, 1H), 1.04 (d, J = 7.0 Hz, 3H); ); MS (APCI) m/z 428 (M+H) ⁺ ; [a] _D ^{22 1} = +7.6, c = 1 (CH ₃ OH); Analytical chiral HPLC elution 4.538 minutes.

Example 79

5-[(3-fluoro-4-methoxybenzoyl)(3-phenylpropyl)amino]pentanoi c acid

[00709] Step 1 : methyl 5-[(3-fluoro-4-methoxybenzoyl)(3-phenylpropyl)amino]pentanoa te

[00710] 3-Fluoro-4-methoxybenzoic acid (68.2 mg, 0.401 mmol) and 1-

[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]py ridinium 3-oxid hexafluorophosphate (183 mg, 0.481 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (155 mg, 1.203 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 70-Step 1 (100 mg, 0.401 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column

chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (120 mg, 0.299 mmol, 74.5% yield).

[00711] Step 2: 5-[(3-fluoro-4-methoxybenzoyl)(3-phenylpropyl)amino]pentanoi c acid

[00712] Material from Example 79-Step 1 (120 mg, 0.299 mmol) was dissolved in tetrahydrofuran (2 mL), and 1 N lithium hydroxide (42.9 mg, 1.793 mmol, 2 mL) was added. The mixture was stirred for 2 hours at 45 °C. The mixture was poured into water, the pH was adjusted to 7, and the mixture was extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC with acetonitrile and water (0.5% CF ₃ C0 ₂ H) to give the titled compound (86 mg, 0.222 mmol, 74.3% yield). Ή NMR (400 MHz, DMSO-<¾) δ ppm 11.79 (s, 1H), 7.27 - 7.03 (m, 8H), 3.86 (s, 3H), 3.2(m, 1H), 2.52 (s, 1H), 2.16 (t, J = 7.3 Hz, 2H), 1.83 (p, J = 7.7 Hz, 2H), 1.58 - 1.46 (m, 2H), 1.42 (s, 2H); LC-MS (ESI) nt/z 387.2 (M+H) ⁺ .

Example 80

5-[(2H-l,34jenzodioxole-5-carbonyl)(3-phenylpropyl)amino]pen tanoic acid

[00713] Step 1 : methyl 5-[(2H-l,3-benzodioxole-5-carbonyl)(3-phenylpropyl)amino]pen tanoate

[00714] To a solution of benzo[(f][l,3]dioxole-5-carboxylic acid (95 mg, 0.572 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (228 mg, 0.601 mmol, HATU) in N,N-dimethylformamide (3 mL) was added triethylamine (0.084 mL 0.601 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then Example 70-Step 1 (143 mg, 0.572 mmol) was added in one portion. The solution was stirred at room temperature overnight. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (200 mg, 0.503 mmol, 88% yield). LC-MS (ESI) nt/z 398.2 (M+H) ⁺ , RT = 1.977 minutes.

[00715] Step 2: 5-[(2H-l,3-benzodioxole-5-carbonyl)(3-phenylpropyl)amino]pen tanoic acid

[00716] To a solution of Example 80-Step 1 (200 mg, 0.503 mmol) in tetrahydrofuran (3 mL) was added 1 N lithium hydroxide (3.02 mL 3.02 mmol). It was stirred at room temperature for 2 hours. The mixture was cooled down and acidified with 1 N HQ to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H-H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (119.6 mg, 0.312 mmol, 62.0% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.23 (dd, J = 8.3, 6.5 Hz, 2H), 7.15 (td, J = 7.8, 6.5, 3.5 Hz, 3H), 6.87 (d, J = 7.9 Hz, 1H), 6.82 (d, J = 1.6 Hz, 1H), 6.77 (dd, J = 7.9, 1.6 Hz, 1H), 6.03 (s, 2H), 3.29 (s, 4H), 2.50 (s, 2H), 2.16 (t, J = 7.1 Hz, 2H), 1.82 (p, J = 7.7 Hz, 2H), 1.50 (d, J = 8.4 Hz, 2H), 1.42 (s, 2H); LC-MS (ESI) nt/z 384.2 (M+H) ⁺ , RT = 1.831 minutes.

Example 81

5-[(4-fluoro-3-methoxybenzoyl)(3-phenylpropyl)amino]pentanoi c acid

[00717] Step 1 : methyl 5-[(4-fluoro-3-methoxybenzoyl)(3-phenylpropyl)amino]pentanoa te

[00718] To a solution of 4-fluoro-3-methoxybenzoic acid (97 mg, 0.572 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (228 mg, 0.601 mmol, HATU) in N,N-dimethylformamide (3 mL) was added triethylamine (0.084 mL 0.601 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then Example 70-Step 1 (143 mg, 0.572 mmol) was added in one portion. The solution was stirred at room temperature overnight. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (184 mg, 0.458 mmol, 80% yield). LC-MS (ESI) m/z 402.2 (M+H) ⁺ , RT = 2.012 minutes.

[00719] Step 2: 5-[(4-fluoro-3-methoxybenzoyl)(3-phenylpropyl)amino]pentanoi c acid

[00720] To a solution of Example 81-Step 1 (184 mg, 0.458 mmol) in tetrahydrofuran (3 mL) was added 1 N lithium hydroxide (2.75 mL 2.75 mmol). The mixture was stirred at room temperature for 2 hours. The mixture was cooled down and acidified with 1 N HC1 to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue which was purified by preparative HPLC(0.1% CF ₃ CO ₂ H-H ₂ O/CH ₃ CN) and lyophilized twice to give the titled compound (135 mg, 0.348 mmol, 76% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.44 - 7.04 (m, 6H), 7.04 (dd, J = 8.3, 2.0 Hz, 1H), 6.84 (ddd, J = 8.2, 4.3, 1.9 Hz, 1H), 3.83 (s, 3H), 3.28 (s, 4H), 2.50 (s, 2H), 2.16 (s, 2H), 1.84 (s, 2H), 1.52 (d, J = 5.7 Hz, 2H), 1.43 (s, 2H); LC-MS (ESI) m/z 388.2 (M+H) ⁺ , RT = 1.861 minutes.

Example 82

5-{ [l-(3-methoxyphenyl)cyclopropane-l-carbonyl](3-phenylpropyl) amino}pentanoic acid

[00721] Step 1 : methyl 5-{ [l-(3-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino } pentanoate

[00722] To a solution of l-(3-methoxyphenyl)cyclopropanecarboxylic acid (110 mg, 0.572 mmol) in N,N-dimethylformamide (3 mL) was added l-[bis(dimethylamino)methylene]-lH- 1,2,3 - triazolo[4,5- ?]pyridinium 3-oxid hexafluorophosphate (217 mg, 0.572 mmol, HATU) and diisopropylethylamine (0.500 mL 2.86 mmol), and the mixture was stirred at room temperature for 15 minutes. Then a solution of Example 70-Step 1 (143 mg, 0.572 mmol) in N,N-dimethylformamide (2 mL) was added to the above solution. The mixture was stirred at room temperature overnight. The mixture was partitioned between water (5 mL) and ethyl acetate (10 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (200 mg, 0.472 mmol, 83% yield). LC-MS (ESI) m/z 424.5 (M+H) ⁺ , RT = 2.09 minutes.

[00723] Step 2: 5-{ [l-(3-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid [00724] To a solution of the material from Example 82-Step 1 (200 mg, 0.472 mmol) in tetrahydrofuran (3 mL) was added 1 N LiOH (1.5 mL). The mixture was stirred at room temperature overnight. Then 1 N HC1 was added to the mixture to adjust pH= 2-3. The mixture was extracted with ethyl acetate (30 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by high pressure liquid chromatography with acetonitrile and water (0.5% CF ₃ C0 ₂ H) to give the titled compound (95 mg, 0.232 mmol, 49.1% yield). *H NMR (400 MHz, DMSO-t¾) 5 ppm 11.76 (s, 1H), 7.20 (ddd, J = 26.1, 12.4, 7.3 Hz, 5H), 7.03 (s, 1H), 6.77 (dd, J = 8.2, 2.5 Hz, 1H), 6.66 (s, 2H), 3.71 (s, 3H), 3.22 (q, J = 8.1, 7.7 Hz, 4H), 2.50-2.48 (m, 1H), 2.39 - 1.93 (m, 3H), 1.75 (brs, 1H), 1.44 (brs, 3H), 1.19 (brs, 4H), 1.03 (brs, 2H); LC-MS (ESI) m/z 410.5 (M+H) ⁺ , RT = 1.93 minutes.

Example 83

5-[(3,4-dimethoxybenzoyl)(3-phenylpropyl)amino]pentanoic acid

[00725] Step 1 : methyl 5-[(3,4-dimethoxybenzoyl)(3-phenylpropyl)amino]pentanoate

[00726] To a solution of 3,4-dimethoxybenzoic acid (104 mg, 0.572 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (228 mg, 0.601 mmol, HATU) in N,N-dimethylformamide (3 mL) was added triethylamine (0.084 mL 0.601 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then Example 70-Step 1 (143 mg, 0.572 mmol) was added in one portion. The solution was stirred at room temperature overnight. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (86 mg, 0.208 mmol, 36.4% yield). LC-MS (ESI) m/z 414.2 (M+H) ⁺ , RT = 1.937 minutes.

[00727] Step 2: 5-[(3,4-dimethoxybenzoyl)(3-phenylpropyl)amino]pentanoic acid

[00728] To a solution of Example 83-Step 1 (86 mg, 0.208 mmol) in tetrahydrofuran (3 mL) was added 1 N LiOH (1.2 mL). The mixture was stirred at room temperature overnight. Then the mixture was acidified with 1 N HC1, and the mixture was extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give the crude which was purified by high pressure liquid chromatography with acetonitrile and water (0.5% CF ₃ C0 ₂ H) to give the titled compound (73 mg, 0.183 mmol, 88% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.23 (t, J = 7.5 Hz, 2H), 7.14 (dd, J = 7.5, 5.3 Hz, 3H), 6.93 (d, J = 8.1 Hz, 1H), 6.89 - 6.80 (m, 2H), 3.78 (s, 3H), 3.75 (s, 3H), 3.30 (t, J = 7.2 Hz, 4H), 2.51 (d, J = 7.3 Hz, 2H), 2.16 (t, J = 7.2 Hz, 2H), 1.84 (p, J = 7.7 Hz, 2H), 1.53 (p, J = 7.3 Hz, 2H), 1.43 (s, 2H); LC-MS (ESI) m/z 400.5 (M+H) ⁺ , RT = 1.788 minutes. Example 84

5-[(4-methoxybenzoyl)(3-phenylpropyl)amino]pentanoic acid

[00729] Step 1 : methyl 5-[(4-methoxybenzoyl)(3-phenylpropyl)amino]pentanoate

[00730] To a solution of 4-methoxybenzoic acid (76 mg, 0.500 mmol) in N,N-dimethylformamide (3 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyr idinium 3-oxid hexafluorophosphate (190 mg, 0.500 mmol, HATU), and the mixture was stirred at room temperature for 15 minutes. Then a solution of Example 70-Step 1 (125 mg, 0.50 mmol) (CF ₃ C0 ₂ H salt) and diisopropylethylamine (0.262 mL 1.500 mmol) in N,N-dimethylformamide (1 mL) was added to the mixture. The mixture was stirred at room temperature for 2 hours. Then water was added to the mixture, and the mixture was extracted with ethyl acetate (20 mL). The organic layer was washed with brine, dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by flash chromatography with hexane and ethyl acetate (0-40%) to give the titled compound (157 mg, 0.409 mmol, 82% yield). LC-MS (ESI) m/z 384.5 (M+H) ⁺ , RT = 2.000 minutes.

[00731] Step 2: 5-[(4-methoxybenzoyl)(3-phenylpropyl)amino]pentanoic acid

[00732] To a solution of material from Example 84-Step 1 (157 mg, 0.409 mmol) in 1,4-dioxane (3 mL) and CH ₃ OH (2 mL) was added 1 N LiOH (2 mL). The mixture was stirred at room temperature overnight. Then 1 N HC1 was added to the mixture to adjust pH = 3-4. Then the mixture was concentrated in vacuum, and the residue was extracted with ethyl acetate (30 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by high pressure liquid chromatography with acetonitrile and water (0.5% CF ₃ C0 ₂ H) to give the titled compound (100 mg, 0.271 mmol, 66.1% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.25-7.21 (m, 4H), 7.19 - 7.07 (m, 3H), 6.98 - 6.86 (m, 2H), 3.78 (s, 3H), 3.32-3.28 (m, 4H), 2.59 - 2.50 (m, 2H), 2.24 - 2.09 (m, 2H), 1.87-1.79 (m, 2H), 1.56-1.48 (m, 2H), 1.42 (brs, 2H); LC-MS (ESI) m/z 370.2 (M+H) ⁺ .

Example 85

5-{ [2-(4-methoxyphenyl)-2-methylpropanoyl](3-phenylpropyl)amino }pentanoic acid

[00733] Step 1 : methyl 5-{ [2-(4-methoxyphenyl)-2-methylpropanoyl](3- phenylpropyl) amino } pentanoate

[00734] To a solution of 2-(4-methoxyphenyl)-2-methylpropanoic acid (27.3 mg, 0.140 mmol) and l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyr idinium 3-oxid hexafluorophosphate (53.4 mg, 0.140 mmol, HATU) in N,N-dimethylformamide (3 mL) was added diisopropylethylamine (0.025 mL 0.140 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then Example 70-Step 1 (35 mg, 0.140 mmol) was added in one portion. The solution was stirred at room temperature overnight. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (50 mg, 0.117 mmol, 84% yield). LC-MS (ESI) m/z 426.2 (M+H) ⁺ , RT = 1.944 minutes.

[00735] Step 2: 5-{ [2-(4-methoxyphenyl)-2-methylpropanoyl](3-phenylpropyl)amino }pentanoic acid

[00736] To a solution of the material of Example 85-Step 1 (50 mg, 0.117 mmol) in 1,4-dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol). The resulting solution was stirred at 30 °C for 2 hours. The reaction was quenched with CF ₃ C0 ₂ H until pH~7-8 and then purified by preparative HPLC (0.1% CF ₃ C0 ₂ H-H ₂ 0/CH ₃ CN) to give the titled compound (26 mg, 0.063 mmol, 53.8% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.32 - 6.83 (m, 9H), 3.72 (s, 3H), 3.16 (s, 2H), 2.81 (s, 2H), 2.10 (d, J = 58.1 Hz, 3H), 1.71 (s, 2H), 1.46 - 1.20 (m, 9H), 0.98 (s, 2H); LC-MS (ESI) m/z 412.2 (M+H) ⁺ .

Example 86

5-{ [ 1 -(4-methoxyphenyl)cyclobutane- 1 -carbonyl](3-phenylpropyl)amino jpentanoic acid

[00737] Step 1 : methyl 5-{ [l-(4-methoxyphenyl)cyclobutane-l-carbonyl](3- phenylpropyl) amino } pentanoate

[00738] The material of Example 70-Step 1 (0.143 mmol) and l-(4- methoxyphenyl)cyclobutanecarboxylic acid (30 mg, 0.145 mmol) was dissolved in N,N- dimethylformamide (3 mL). l-[Bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyr idinium 3- oxid hexafluorophosphate (54.4 mg, 0.143 mmol, HATU) and diisopropylethylamine (0.050 mL 0.286 mmol) were added into the mixture. The resulting solution was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (50 mg, 0.114 mmol, 80% yield). LC-MS (ESI) m/z 438.2 (M+H) ⁺ .

[00739] Step 2: 5-{ [l-(4-methoxyphenyl)cyclobutane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid

[00740] To a solution of the material of Example 86-Step 1 (50 mg, 0.114 mmol) in 1,4-dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The reaction was quenched with CF ₃ C0 ₂ H until pH~7-8 and then purified by preparative HPLC eluted with CH ₃ CN/H ₂ 0/NH ₄ OH to give the titled compound (40 mg, 0.094 mmol, 83% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.33 - 7.09 (m, 6H), 7.01 - 6.85 (m, 3H), 3.78 (s, 3H), 3.30 - 3.25 (m, 2H), 2.89 (q, J = 7.2 Hz, 2H), 2.82 - 2.63 (m, 2H), 2.57 (t, J = 7.8 Hz, 1H), 2.35 (ddd, J = 12.3, 9.3, 3.7 Hz, 1H), 2.29 - 2.13 (m, 3H), 2.04 - 1.70 (m, 4H), 1.55 (p, J = 3.0 Hz, 2H), 1.35 - 1.19 (m, 2H); LC-MS (ESI) m/z 424.2 (M+H) ⁺ . Example 87

(2- { [ 1 -(4-methoxyphenyl)cyclopropane- 1 -carbonyl] (3-phenylpropyl)amino } ethoxy)acetic acid

[00741] Step 1 : N-(2-hydroxyethyl)-l-(5-methoxypyridin-2-yl)-N-(3-phenylprop yl)cyclopropane- 1-carboxamide

[00742] A solution of teri-butyl (2-hydroxyethyl)(3-phenylpropyl)carbamate (200 mg, 0.716 mmol, Accela ChemBio Co., Ltd) in hydrochloric acid/ethyl acetate (0.5 mL 2.000 mmol) was stirred at room temperature for 2 hours and then concentrated. The residue was dissolved in N,N- dimethylformamide (3 mL), and then l-(5-methoxypyridin-2-yl)cyclopropanecarboxylic acid (138 mg, 0.716 mmol), l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyr idinium 3-oxid hexafluorophosphate (272 mg, 0.716 mmol, HATU) and diisopropylethylamine (0.250 mL 1.432 mmol) were added thereto. The resulting solution was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue. The residue was purified by flash chromatography on silica gel eluted with ethyl acetate in hexane from 30% to 100% to give the titled compound (150 mg, 0.423 mmol, 59.1% yield). LC-MS (ESI) m/z 354.2 (M+H) ⁺ .

[00743] Step 2: methyl (2-{ [l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino } ethoxy) acetate

[00744] To a solution of the material of Example 87-Step 1 (89 mg, 0.252 mmol) and methyl 2- chloroacetate (0.066 mL 0.755 mmol) in tetrahydrofuran (3.0 mL) was added potassium teri-butoxide (85 mg, 0.755 mmol) in one portion. The mixture was heated to reflux for 1 hour. The mixture was cooled down and quenched with saturated aqueous NH ₄ C1. The mixture was extracted with ethyl acetate 3 times. The combined organic layers were washed with brine once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (80 mg, 0.188 mmol, 74.7% yield). LC-MS (ESI) m/z 426.2 (M+H) ⁺ .

[00745] Step 3: (2-{ [l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino } ethoxy) acetic acid

[00746] To a solution of the material of Example 87-Step 2 (80 mg, 0.188 mmol) in 1,4-dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The reaction mixture was stirred at 30 °C for 1 hour. The mixture was purified by preparative HPLC eluting with CH ₃ CN/H ₂ 0/NH ₄ OH to give the titled compound (7 mg, 0.017 mmol, 3.40% yield). *H NMR (400 MHz, methanol- ¾ δ ppm 7.29 - 7.10 (m, 4H), 7.05 - 6.96 (m, 3H), 6.90 - 6.80 (m, 2H), 3.95 (s, 1H), 3.76 (d, J = 1.3 Hz, 3H), 3.69 - 3.38 (m, 6H), 3.19 (t, J = 6.0 Hz, 1H), 2.57 (t, J = 7.8 Hz, 1H), 2.34 (t, J = 7.5 Hz, 1H), 1.85 (p, J = 7.8 Hz, 1H), 1.45 (s, 1H), 1.32 (t, J = 3.4 Hz, 1H), 1.30 - 1.20 (m, 1H), 1.14 (q, J = 4.7 Hz, 1H), 1.02 - 0.94 (m, 1H); LC-MS (ESI) m/z 412.2 (M+H) ⁺ . Example 88

5 - { [4-(2-hydroxyethoxy) -3,5 -dimethoxybenzoyl] (3 -phenylpropyl)amino } pentanoic acid

[00747] Step 1 : methyl 4-(2-{ [teri4jutyl(dimethyl)silyl]oxy}ethoxy)-3,5-dimethoxybenzoate

[00748] A mixture of (2-bromoethoxy)(teri-butyl)dimethylsilane (451 mg, 1.885 mmol), methyl 4- hydroxy-3,5-dimethoxybenzoate (200 mg, 0.943 mmol) and potassium carbonate (391 mg, 2.83 mmol) in N,N-dimethylformamide (5 mL) were stirred at 110 °C for 1 hour. Then the mixture was cooled down to room temperature, diluted with water (15 mL), and extracted with ethyl acetate 3 times. The combined organic layers were dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded with CH ₂ C1 ₂ , elute: hexanes/ethyl acetate=0~30 ) to give the titled compound (340 mg, 0.918 mmol, 97% yield). LC- MS (ESI) m/z 371.2 (M+H) ⁺ , RT = 2.283 minutes.

[00749] Step 2: 4-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethoxy)-3,5-dimethoxybenzoic acid

[00750] To a solution of the material of Example 88-Step 1 (340 mg, 0.918 mmol) in

tetrahydrofuran (5 mL) was added 1 N lithium hydroxide (5.51 mL 5.51 mmol). The mixture was stirred at 60 °C for 7 hours. It was cooled down and acidified with 1 N HC1 to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (250 mg, 0.701 mmol, 76% yield). LC-MS (ESI) m/z 357.2 (M+H) ⁺ , RT = 2.083 minutes.

[00751] Step 3: methyl 5-{ [4-(2-{ [teri-butyl(dimethyl)silyl]oxy }ethoxy)-3,5- dimethoxybenzoyl] (3 -phenylpropyl) amino } pentanoate

[00752] To a solution of the material of Example 88-Step 2 (150 mg, 0.421 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (168 mg, 0.442 mmol, HATU) in N,N-dimethylformamide (3 mL) was added triethylamine (0.062 mL 0.442 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then Example 70-Step 1 (440 mg, 0.884 mmol) was added in one portion. The solution was stirred at room temperature for 1 hour. The mixture was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (93 mg, 0.138 mmol, 32.7% yield). LC-MS (ESI) m/z 588.4 (M+H) ⁺ , RT = 2.350 minutes.

[00753] Step 4: methyl 5-{ [4-(2-hydroxyethoxy)-3,5-dimethoxybenzoyl](3- phenylpropyl) amino } pentanoate

[00754] To a solution of the material of Example 88-Step 3 (93 mg, 0.158 mmol) in

tetrahydrofuran (2 mL) was added tetra-«-butylammonium fluoride (165 mg, 0.633 mmol). The mixture was stirred at 30 °C for 1 hour. It was concentrated to give a residue which was diluted with water and extracted with teri-butyl methyl ether 3 times. The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (73 mg, 0.154 mmol, 97% yield). LC-MS (ESI) nt/z 474.2 (M+H) ⁺ , RT = 1.835 minutes.

[00755] Step 5: 5-{ [4-(2-hydroxyethoxy)-3,5-dimethoxybenzoyl](3- phenylpropyl) amino jpentanoic acid

[00756] To a solution of the material of Example 88-Step 4 (73 mg, 0.154 mmol) in

tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (0.925 mL 0.925 mmol). The mixture was stirred at 30 °C for 1 hour. The mixture was cooled down and acidified with 1 N HC1 to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by preparative HPLC (0.1% NH ₃ ^» H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (35 mg, 0.076 mmol, 49.4% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.28 - 7.08 (m, 5H), 6.56 (s, 2H), 3.91 (t, J = 5.7 Hz, 2H), 3.76 (s, 6H), 3.62 (t, J = 5.7 Hz, 2H), 3.28 (s, 2H), 3.15 (s, 2H), 2.52 (s, 2H), 2.14 (s, 2H), 1.86 (q, J = 7.5 Hz, 2H), 1.54 (s, 2H), 1.43 (s, 2H); LC-MS (ESI) nt/z 460.2 (M+H) ⁺ , RT = 1.700 minutes.

Example 89

5-{ [3-(4-methoxyphenyl)oxetane-3-carbonyl](3-phenylpropyl)amino }pentanoic acid

[00757] Step 1 : methyl 5-{ [3-(4-methoxyphenyl)oxetane-3-carbonyl](3- phenylpropyl) amino } pentanoate

[00758] To a solution of 3-(4-methoxyphenyl)oxetane-3-carboxylic acid (29.2 mg, 0.140 mmol) in N,N-dimethylformamide (8 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (56.0 mg, 0.147 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 70-Step 1 (0.140 mmol) was added in one portion followed by the addition of diisopropylethylamine (0.025 mL 0.140 mmol). The solution was stirred at room temperature for 1 hour. The reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (50 mg, 0.114 mmol, 81% yield). LC- MS (ESI) nt/z 440.2 (M+H) ⁺ , RT = 1.994 minutes.

[00759] Step 2: 5-{ [3-(4-methoxyphenyl)oxetane-3-carbonyl](3-phenylpropyl)amino }pentanoic acid

[00760] To a solution of the material of Example 89-Step 1 (50 mg, 0.114 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The reaction mixture was stirred at 30 °C for 1 hour. The mixture was purified by preparative HPLC eluting with CH ₃ CN/H ₂ 0/NH ₄ OH to give the titled compound (25 mg, 0.059 mmol, 51.6% yield). *H NMR (400 MHz, methanol- ¾ δ ppm 7.42 - 7.34 (m, 1H), 7.31 - 7.11 (m, 5H), 6.97 (dd, J = 10.9, 8.2 Hz, 3H), 5.19 (d, J = 6.2 Hz, 1H), 5.07 (d, J = 6.1 Hz, 1H), 4.76 (d, J = 6.1 Hz, 1H), 4.43 (d, J = 6.1 Hz, 1H), 3.81 (d, J = 5.5 Hz, 3H), 3.42 - 3.33 (m, 2H), 2.65 (ddd, J = 15.7, 10.8, 7.7 Hz, 3H), 2.36 - 2.22 (m, 2H), 1.93 (dt, J = 28.2, 7.4 Hz, 2H), 1.60 (p, J = 3.7 Hz, 2H), 1.54 - 1.42 (m, 1H), 1.27 - 1.08 (m, 2H); LC-MS (ESI) m/z 426.2 (M+H) ⁺ , RT = 1.607 minutes.

Example 90

5- { (3 , 5 -dimethoxybenzoyl) [3 -(3 -fluorophenyl)propyl] amino } pentanoic acid

[00761] Step 1 : methyl 5-{ [3-(3-fluorophenyl)propyl]amino}pentanoate

[00762] To a solution of 3-(3-fluorophenyl)propan-l -amine (300 mg, 1.958 mmol) in acetonitrile (5 mL) was added methyl 5-bromopentanoate (382 mg, 1.958 mmol), and the resultant solution was heated to 80 °C for 1.5 hours. Then the mixture was cooled to room temperature and concentrated to give the titled compound. LC-MS (ESI) m/z 268.5 (M+H) ⁺ , RT = 1.51 minutes.

[00763] Step 2: methyl 5-{(3,5-dimethoxybenzoyl)[3-(3-fluorophenyl)propyl]amino}pen tanoate

[00764] To a solution of 3,5-dimethoxybenzoic acid (357 mg, 1.958 mmol) in N,N- dimethylformamide (5 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (744 mg, 1.958 mmol, HATU) and diisopropylethylamine (0.342 mL 1.958 mmol). The mixture was stirred at room temperature for 15 minutes. Then a solution of the material of Example 90-Step 1 (523 mg, 1.958 mmol) in acetonitrile (5 mL) was added to the mixture. The mixture was stirred at room temperature for 1 hour. Then the mixture was partitioned between water (20 mL) and ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue that was purified by silica gel chromatography with hexane and ethyl acetate (0-30%) to give the titled compound (324 mg, 0.751 mmol, 38.3% yield). LC-MS (ESI) m/z 432.5 (M+H) ⁺ , RT = 1.997 minutes.

[00765] Step 3: 5-{(3,5-dimethoxybenzoyl)[3-(3-fluorophenyl)propyl]amino}pen tanoic acid

[00766] To a solution of the material of Example 90-Step 2 (324 mg, 0.751 mmol) in

tetrahydrofuran (5 mL) and CH ₃ OH (2 mL) was added 1 N LiOH (3.75 mmol, 3.75 mL). The mixture was stirred at room temperature for 1 hour. Then the mixture was concentrated, and the residue was partitioned between water (5 mL) and diethyl ether (10 mL), and the mixture was washed with diethyl ether. The aqueous layer was acidified with 1 N HC1 to pH = 2-3 and extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by high pressure liquid column chromatography with acetonitrile and water to give the titled compound (190 mg, 0.455 mmol, 60.6% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.28 (brs, 1H), 7.42 - 6.77 (m, 4H), 6.48 (d, J = 16.7 Hz, 1H), 6.37 (d, J = 16.6 Hz, 2H), 3.73 (s, 3H), 3.71 (s, 3H), 3.37-3.35 (m, 2H), 3.11 (q, J = 9.8, 6.5 Hz, 2H), 2.63 (t, J = 8.0 Hz, 1H), 2.40 (t, J = 7.6 Hz, 1H), 2.24 (d, J = 6.5 Hz, 1H), 2.07 (d, J = 9.0 Hz, 1H), 1.81 (dp, J = 39.9, 7.5, 7.0 Hz, 2H), 1.65 - 1.38 (m, 3H), 1.27 (q, J = 8.0, 7.4 Hz, 1H); LC-MS (ESI) nt/z 418.5 (M+H) ⁺ , RT = 1.860 minutes.

Example 91

5-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pentan oic acid

[00767] Step 1 : methyl 5-{ [3-(3-chlorophenyl)propyl]amino}pentanoate

[00768] To a solution of 3-(3-chlorophenyl)propan-l -amine (300 mg, 1.768 mmol) in acetonitrile (5 mL) was added methyl 5-bromopentanoate (345 mg, 1.768 mmol), and the solution was heated to 80 °C for 1 hour. Then K ₂ C0 ₃ (733 mg, 5.30 mmol) was added, and the mixture was heated to 80 °C for an additional 1 hour. Then the mixture was cooled to room temperature and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound.

[00769] Step 2: methyl 5-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pentan oate

[00770] To a solution of 3,5-dimethoxybenzoic acid (322 mg, 1.768 mmol) in N,N- dimethylformamide (5 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (672 mg, 1.768 mmol, HATU) and diisopropylethylamine (0.309 mL 1.768 mmol). The mixture was stirred at room temperature for 15 minutes. Then a solution of the material from Example 91 -Step 1 (502 mg, 1.768 mmol) in acetonitrile (5 mL) was added to the mixture. The mixture was stirred at room temperature for 1 hour. Then the mixture was partitioned between water (20 mL) and ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to dryness. The residue was purified by chromatography with hexane and ethyl acetate (0-30%) to give the titled compound (110 mg, 0.246 mmol, 13.89% yield). LC-MS (ESI) nt/z 448.5 (M+H) ⁺ , RT = 2.060 minutes.

[00771] Step 3: 5-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pentan oic acid

[00772] To a solution of the material from Example 91-Step 2 (110 mg, 0.246 mmol) in tetrahydrofuran (5 mL) and CH ₃ OH (2 mL) was added 1 N LiOH (1.23 mmol, 1.2 mL). The mixture was stirred at room temperature for 1 hour. Then the mixture was concentrated, and the residue was partitioned between water (5 mL) and diethyl ether (10 mL). The aqueous fraction was washed with diethyl ether, and the aqueous layer was acidified with 1 N HC1 to pH = 2-3 and then extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified with high pressure liquid column chromatography eluted with acetonitrile and water (0.5% CF ₃ C0 ₂ H) to give the titled compound (84 mg, 0.194 mmol, 79% yield). H NMR (400 MHz, DMSO-<¾) δ ppm 12.04 (brs, 1H), 7.40 - 6.93 (m, 4H), 6.49 (d, J = 14.2 Hz, 1H), 6.38 (d, J = 16.3 Hz, 2H), 3.72 (s, 6H), 3.37 (d, J = 7.5 Hz, 2H), 3.12 (q, J = 8.7, 8.1 Hz, 2H), 2.62 (t, J = 7.8 Hz, 1H), 2.39 (t, J = 7.7 Hz, 1H), 2.26 (d, J = 7.6 Hz, 1H), 2.06 (s, 1H), 1.81 (ddd, J = 42.5, 12.0, 6.4 Hz, 2H), 1.61 - 1.40 (m, 3H), 1.36 - 1.19 (m, 1H); LC-MS (ESI) m/z 434.5 (M+H) ⁺ , RT = 1.910 minutes. Example 92

5-{ [3-(3-fluorophenyl)propyl] [l-(4-methoxyphenyl)cyclopropane-l-carbonyl]amino}pentanoic acid

[00773] Step 1 : methyl 5-{ [3-(3-fluorophenyl)propyl] [l-(4-methoxyphenyl)cyclopropane-l- carbonyl] amino } pentanoate

[00774] To a solution of l-(4-methoxyphenyl)cyclopropanecarboxylic acid (259 mg, 1.347 mmol) in N,N-dimethylformamide (8 mL) was added l-[bis(dimethylamino)methylene]-lH- 1,2,3 - triazolo[4,5- ?]pyridinium 3-oxid hexafluorophosphate (538 mg, 1.414 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 90-Step 1 in N,N-dimethylformamide (2.0 mL) was added in one portion followed by the addition of

diisopropylethylamine (0.235 mL 1.347 mmol). The solution was stirred at room temperature for 1 hour. The mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on reverse phase silica d ₈ eluting with CH ₃ CN in water (0.1% NH ₄ HC0 ₃ ) from 20% to 70% over 15 minutes to give the titled compound (100 mg, 0.226 mmol, 16.82% yield). H NMR (400 MHz, methanol-^) δ ppm 7.37 - 7.19 (m, 2H), 7.19 - 7.12 (m, 1H), 7.02 (t, J = 8.9 Hz, 2H), 6.98 - 6.80 (m, 4H), 3.77 (s, 3H), 3.63 (d, J = 8.5 Hz, 3H), 3.35 (dd, J = 8.2, 2.7 Hz, 2H), 3.29 (s, 1H), 2.60 (t, J = 7.8 Hz, 1H), 2.39 - 2.30 (m, 3H), 2.10 (t, J = 7.3 Hz, 1H), 1.90 - 1.78 (m, 1H), 1.54 (dq, J = 5.9, 3.6 Hz, 3H), 1.39 (dt, J = 15.9, 7.8 Hz, 2H), 1.25 (dq, J = 21.5, 4.4, 3.4 Hz, 3H), 1.18 - 1.05 (m, 2H), 1.01 (q, J = 4.6 Hz, 1H); LC-MS (ESI) nt/z 442.5 (M+H) ⁺ , RT = 2.079 minutes.

[00775] Step 2: 5-{ [3-(3-fluorophenyl)propyl][l-(4-methoxyphenyl)cyclopropane-l - carbonyl] amino jpentanoic acid

[00776] To a solution of Example 92-Step 1 (100 mg, 0.226 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The reaction mixture was purified by preparative HPLC eluting with CH ₃ CN/H ₂ O/CF ₃ CO ₂ H to give the titled compound (42 mg, 0.098 mmol, 43.4% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.32 - 7.13 (m, 2H), 7.06 - 6.80 (m, 5H), 6.74 (dd, J = 10.1, 2.5 Hz, 1H), 3.76 (s, 3H), 3.40 - 3.32 (m, 3H), 2.59 (t, J = 7.8 Hz, 1H), 2.32 (dt, J = 13.7, 7.3 Hz, 2H), 2.07 (t, J = 7.3 Hz, 1H), 1.84 (p, J = 7.8 Hz, 1H), 1.56 (dd, J = 7.2, 3.6 Hz, 2H), 1.46 - 1.17 (m, 5H), 1.19 - 1.06 (m, 2H), 1.01 (q, J = 4.5 Hz, 1H); LC- MS (ESI) nt/z 428.5 (M+H) ⁺ , RT = 1.914 minutes.

Example 93

2-{3-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]p ropyl}hexanoic acid

[00777] Step l : methyl 2-{3-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] propyl } hexanoate [00778] To a solution of diisopropylamine (0.362 mL 2.57 mmol) in tetrahydrofuran (5 mL) was added butyllithium (150 mg, 2.339 mmol) at 0 °C. The mixture was stirred at 0-5 °C for 30 minutes, then a solution of Example 70-Step 2 (500 mg, 1.169 mmol) in tetrahydrofuran at -78 °C was added slowly, followed by 1-bromobutane (0.139 mL 1.286 mmol). The mixture was stirred at -78 °C and warmed-up to ambient temperature over 4 hours. The titled compound was obtained after purification by flash chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%). LC-MS (ESI) nt/z 484.3 (M+H) ⁺ .

[00779] Step 2: 2-{3-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]p ropyl}hexanoic acid

[00780] Example 93-Step 1 (20 mg, 0.041 mmol) was dissolved in tetrahydrofuran (2 mL), and 1 N lithium hydroxide (5.94 mg, 0.248 mmol) solution (2 mL) was added. The mixture was stirred for 2 hours at room temperature. The mixture was poured into water. The pH was adjusted to 7, and the aqueous mixture was extracted with ethyl acetate three times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1% CF ₃ CO ₂ H-H ₂ O/CH ₃ CN) to give the titled compound (9 mg, 0.019 mmol, 46.3% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.45 - 6.92 (m, 5H), 6.50 (s, 2H), 3.76 (s, 6H), 3.16 (s, 2H), 2.61 (s, 2H), 2.41 (s, 1H), 2.16 (s, 1H), 2.00 (s, 3H), 1.85 (d, J = 31.9 Hz, 2H), 1.52 (m, 5H), 1.24 (s, 6H), 0.85 (s, 3H).

Example 94

5-[benzyl(3,5-dimethoxy-4-methylbenzoyl)amino]pentanoic acid

[00781] Step 1 : methyl 5-(benzylamino)pentanoate

[00782] Phenylmethanamine (200 mg, 1.866 mmol) and potassium carbonate (310 mg, 2.240 mmol) were dissolved in dry CH ₃ CN (6 mL) at room temperature. Methyl 5-bromopentanoate (400 mg, 2.053 mmol) dissolved in dry CH ₃ CN was added slowly to the mixture, and then the mixture was stirred at reflux for 3 hours. Then the mixture was cooled down and filtered to give the titled compound.

[00783] Step 2: methyl 5-[benzyl(3,5-dimethoxy-4-methylbenzoyl)amino]pentanoate

[00784] 3,5-Dimethoxy-4-methylbenzoic acid (432 mg, 2.200 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (837 mg, 2.200 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (775 mg, 6.00 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 94-Step 1 (443 mg, 2.0 mmol) was added, the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (230 mg, 0.576 mmol, 28.8% yield).

[00785] Step 3: 5-[benzyl(3,5-dimethoxy-4-methylbenzoyl)amino]pentanoic acid

[00786] Example 94-Step 2 (230 mg, 0.576 mmol) was dissolved in tetrahydrofuran (2 mL), and 1 N lithium hydroxide (83 mg, 3.45 mmol) solution (2 mL) was added. The mixture was stirred for 2 hours at room temperature. The mixture was poured into water, the pH was adjusted to 7, and the mixture was extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H-H ₂ 0/CH ₃ CN) to give the titled compound (106 mg, 0.275 mmol, 47.8% yield). *H NMR (400 MHz, DMSO-i¾) δ ppm 7.53 - 7.10 (m, 5H), 6.58 (s, 2H), 4.57 (d, J = 76.0 Hz, 2H), 3.81 (s, 6H), 3.36 (s, 1H), 3.12 (s, 1H), 2.25 (s, 1H), 2.14 - 2.04 (m, 1H), 1.99 (d, J = 16.7 Hz, 3H), 1.54 (s, 3H), 1.29 (s, 1H); LC-MS (ESI) m/z 386.2 (M+H) ⁺ .

Example 95

5- [(3 ,5 -dimethoxy-4-methylbenzoyl)(2-phenylethyl)amino]pentanoic acid

[00787] Step 1 : methyl 5- [(2-phenylethyl) amino] pentanoate

[00788] 2-Phenylethanamine (200 mg, 1.650 mmol) and potassium carbonate (274 mg, 1.981 mmol) were dissolved in dry CH ₃ CN (6 mL) at room temperature. Methyl 5-bromopentanoate (354 mg, 1.815 mmol) dissolved in dry CH ₃ CN was added slowly to the mixture, and then the mixture was stirred at reflux for 3 hours. Then the mixture was cooled down and filtered to give the titled compound.

[00789] Step 2: methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(2-phenylethyl)amino]penta noate

[00790] 3,5-Dimethoxy-4-methylbenzoic acid (391 mg, 1.991 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (757 mg, 1.991 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (702 mg, 5.43 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 95-Step 1 (426 mg, 1.81 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (176 mg, 0.426 mmol, 23.52% yield).

[00791] Step 3: 5-[(3,5-dimethoxy-4-methylbenzoyl)(2-phenylethyl)amino]penta noic acid

[00792] Example 95-Step 2 (160 mg, 0.387 mmol) was dissolved in tetrahydrofuran (2 mL) and 1 N lithium hydroxide (55.6 mg, 2.322 mmol) solution (2 mL) was added. The mixture was stirred for 2 hours at room temperature. The mixture was poured into water, the pH was adjusted to 7, and the aqueous mixture was extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H-H ₂ 0/CH ₃ CN) to give the titled compound (76 mg, 0.190 mmol, 49.2% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.43 - 7.13 (m, 4H), 7.01 (s, 1H), 6.43 (s, 2H), 3.60 (s, 1H), 3.43 (d, J = 31.4 Hz, 2H), 3.08 (s, 1H), 2.87 (d, J = 38.3 Hz, 2H), 2.30 (s, 1H), 2.16 (s, 1H), 2.00 (s, 3H), 1.53 (d, J = 42.3 Hz, 3H), 1.29 (s, 1H); LC-MS (ESI) m/z 400.2 (M+H) ⁺ .

Example 96

5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (4-phenylbutyl)amino] pentanoic acid

[00793] Step 1 : methyl 5-[(4-phenylbutyl)amino]pentanoate

[00794] 4-Phenylbutan-l -amine (200 mg, 1.340 mmol) and potassium carbonate (222 mg, 1.608 mmol) were dissolved in dry CH ₃ CN (6 mL) at room temperature. Methyl 5-bromopentanoate (288 mg, 1.474 mmol) dissolved in dry CH ₃ CN was added slowly to the mixture; then the mixture was stirred at reflux for 3 hours. Then the mixture was cooled down and filtered to give the titled compound. MS (ESI) m/z 264.2 (M+H) ⁺ .

[00795] Step 2: methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(4-phenylbutyl)amino]penta noate

[00796] 3,5-Dimethoxy-4-methylbenzoic acid (317 mg, 1.617 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (615 mg, 1.617 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (570 mg, 4.41 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 96-Step 1 (387 mg, 1.47 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (312 mg, 0.707 mmol, 48.1% yield).

[00797] Step 3: 5-[(3,5-dimethoxy-4-methylbenzoyl)(4-phenylbutyl)amino]penta noic acid

[00798] Example 96-Step 2 (270 mg, 0.611 mmol) was dissolved in tetrahydrofuran (2 mL), and 1 N lithium hydroxide (88 mg, 3.67 mmol) solution (2 mL) was added. The mixture was stirred for 2 hours at room temperature. The mixture was poured into water, the pH was adjusted to 7, and the aqueous mixture was extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, and dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H-H ₂ 0/CH ₃ CN) to give the titled compound (76 mg, 0.178 mmol, 29.1% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.38 - 6.98 (m, 5H), 6.49 (s, 2H), 3.77 (m, 6H), 3.37 (s, 3H), 3.17 (s, 2H), 2.64 (s, 1H), 2.46 (s, 1H), 2.27 (s, 1H), 2.09 (d, J = 9.3 Hz, 1H), 2.00 (s, 3H), 1.57 (d, J = 28.0 Hz, 6H), 1.35 (d, J = 37.6 Hz, 2H). MS (ESI) m/z 428.2 (M+H) ⁺ . Example 97

2-{3-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]p ropyl}-2-methylhexanoic acid

[00799] Step 1 : methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2- methylpentanoate

[00800] To a solution of diisopropylamine (1.467 mL, 10.29 mmol) in tetrahydrofuran (10 mL) was added «-butyllithium (10.29 mmol, 6.4 mL, 1.6 M in hexane) at 0 °C under N ₂ atmosphere. The mixture was stirred at 0 °C for 0.5 hour, and cooled to -78 °C. Then a solution of Example 70-Step 2 (2 g, 4.68 mmol) in tetrahydrofuran (10 mL) was added to the mixture dropwise, and the mixture was stirred at -78 °C for 10 minutes. Then methyl iodide (0.878 mL, 14.03 mmol) was added to the mixture with continued stirring at -78 °C to room temperature for 2 hours. Then the reaction was quenched with saturated NH ₄ C1 and the mixture was extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to dryness. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (1.74 g, 3.94 mmol, 84% yield). LC-MS (ESI) m/z 442.2 (M+H) ⁺ , RT = 2.15 minutes.

[00801] Step 2: methyl 2-{3-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]p ropyl}-2- methylhexanoate

[00802] To a solution of diisopropylamine (0.177 mL, 1.25 mmol) in tetrahydrofuran (5 mL) was added «-butyllithium (1.19 mmol, 0.74 mL, 1.6 M in hexane) at 0 °C under N ₂ atmosphere. The mixture was stirred at 0 °C for 0.5 hour, and cooled to -78 °C. Then a solution of Example 97-Step 1 (250 mg, 0.566 mmol) in tetrahydrofuran (5 mL) was added to the mixture dropwise, and the mixture was stirred at -78 °C for 10 minutes. Then 1-bromobutane (233 mg, 1.699 mmol) was added to the mixture with continued stirring at -78 °C to room temperature for 2 hours. Then reaction was quenched with saturated NH ₄ C1, and the mixture was extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to dryness. The residue was purified by flash chromatography on silica gel eluted with hexane and ethyl acetate to give the titled compound (20 mg, 0.032 mmol, 5.68% yield). LC-MS (ESI) m/z 498.2 (M+H) ⁺ , RT = 2.36 minutes.

[00803] Step 3: 2-{3-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]p ropyl}-2- methylhexanoic acid

[00804] To a solution of Example 97-Step 2 (20 mg, 0.040 mmol) in tetrahydrofuran (1 mL) was added 1 N LiOH (0.804 mmol, 0.8 mL), and the mixture was stirred at room temperature overnight. Then the mixture was heated to 50 °C overnight. Then 2 N KOH (1 mL) was added to the mixture which was then heated to 50 °C overnight. The mixture was cooled to room temperature and 1 N HCl was added to the mixture to adjust pH = 2-3 followed by extraction with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 , filtered and concentrated. The residue was purified by high pressure liquid chromatography with acetonitrile and water (0.5% CF ₃ C0 ₂ H) to give the titled compound (11 mg, 0.023 mmol, 56.6% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.07 (s, 1H), 7.16 (dt, J = 54.4, 24.3 Hz, 5H), 6.48 (s, 2H), 3.74 (s, 6H), 3.13 (s, 2H), 2.62 (s, 1H), 2.39 (s, 1H), 1.98 (s, 3H), 1.93 - 1.67 (m, 2H), 1.62 - 1.05 (m, 10H), 0.98 (d, J = 31.9 Hz, 3H), 0.90 - 0.71 (m, 3H); LC-MS (ESI) m/z 484.2 (M+H) ⁺ , RT = 2.20 minutes.

Example 98

5- [(3 ,5 -dimethoxybenzoyl)(3-phenylpropyl)amino] -2-methylpentanoic acid

[00805] Step 1 : methyl 5-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]-2-methylpent anoate

[00806] To a solution of diisopropylamine (325 mg, 3.21 mmol) in tetrahydrofuran (15 mL) was added butyllithium (1.882 mL, 3.01 mmol) at 0 °C under N ₂ atmosphere. The mixture was stirred at 0 °C for 15 minutes, and cooled to -78 °C. Then a solution of Example 74-Step 1 (830 mg, 2.007 mmol) in tetrahydrofuran (6 mL) was added to the mixture drop wise, and the mixture was stirred at - 78 °C for 25 minutes. Then iodomethane (1425 mg, 10.04 mmol) was added to the mixture with continued stirring at -78 °C to -30 °C over 2 hours. Aqueous NH ₄ C1 was added to the mixture, and the mixture was extracted with ethyl acetate (60 mL). The organic fraction was dried and

concentrated. The residue was purified by chromatography on silica gel eluted with hexanes and ethyl acetate (from 0-50%) to give the titled compound (720 mg, 1.684 mmol, 84% yield). ¾ NMR (400 MHz, CDC1 ₃ ) δ ppm 7.39 - 7.10 (m, 4H), 7.10 - 6.95 (m, 1H), 6.51 - 6.36 (m, 3H), 3.79 (s, 6H), 3.71 - 3.59 (m, 3H), 3.46 (brs, 2H), 3.21 (brs, 2H), 2.69 (brs, 1H), 2.56 - 2.21 (m, 2H), 1.98 (brs, 1H), 1.84 (brs, 1H), 1.63 (brs, 2H), 1.45 (d, J = 15.9 Hz, 2H), 1.21 - 0.99 (m, 3H); LC-MS (ESI) m/z 428.2 (M+H) ⁺ , RT = 2.08 minutes.

[00807] Step 2: 5-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]-2-methylpent anoic acid

[00808] To a solution of Example 98-Step 1 (220 mg, 0.515 mmol) in 1,4-dioxane (5 mL) was added 1 N LiOH (5.15 mL 5.15 mmol), and the mixture was heated to 70 °C overnight. Then the mixture was cooled to room temperature and concentrated. The residue was diluted with water and washed with ethyl ether (20 mL). The aqueous layer was acidified with 1 N HC1 to pH = 2-3 and extracted with ethyl acetate (30 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by high pressure liquid chromatography eluted with acetonitrile and water (0.5% CF ₃ C0 ₂ H) to give the titled compound (203 mg, 0.491 mmol, 95% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.08 (s, 1H), 7.40 - 6.92 (m, 5H), 6.50 (d, J = 3.7 Hz, 1H), 6.38 (s, 2H), 3.73 (s, 6H), 3.43 - 3.30 (m, 2H), 3.10 (d, J = 8.3 Hz, 2H), 2.61 (t, J = 7.8 Hz, 1H), 2.38 (t, J = 7.7 Hz, 1H), 2.16 (q, J = 7.3, 6.5 Hz, 1H), 1.80 (dq, J = 36.9, 8.5 Hz, 2H), 1.53 (d, J = 10.0 Hz, 2H), 1.47 - 1.25 (m, 2H), 1.05 (d, J = 6.8 Hz, 2H), 1.00 - 0.90 (m, 1H); LC-MS (ESI) m/z 414.2 (M+H) ⁺ , RT = 1.92 minutes. Example 99

5-[(4-fluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pent anoic acid

[00809] Step 1 : methyl 5-[(4-fluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pent anoate

[00810] To a solution of 4-fluoro-3,5-dimethoxybenzoic acid (150 mg, 0.749 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (313 mg, 0.824 mmol, HATU) in N,N-dimethylformamide (3 mL) was added triethylamine (0.115 mL 0.824 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then to a solution of Example 70-Step 1 (392 mg, 0.787 mmol) in CH ₂ C1 ₂ (4 mL) was added triethylamine (2 mL) dropwise. After addition, the mixture was added to the above solution in one portion. The resulting solution was stirred at room temperature for 1 hour. Then the mixture was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-40%) to give the titled compound (230 mg, 0.533 mmol, 71.1% yield). LC-MS (ESI) m/z 432.2 (M+H) ⁺ , RT = 2.00 minutes.

[00811] Step 2: 5-[(4-fluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]pent anoic acid

[00812] To a solution of Example 99-Step 1 (230 mg, 0.533 mmol) in tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (3.20 mL 3.20 mmol). The mixture was stirred at room temperature for 1 hour. The mixture was cooled down and acidified with 1 N HC1 to pH=2-3. The mixture was extracted with ethyl acetate twice, and the combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H-H ₂ 0/CH ₃ CN) and lyophilized to give an oil (150 mg). The oil was further purified with a second preparative HPLC (0.1 % CF ₃ C0 ₂ H-H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (110 mg, 0.263 mmol, 49.4% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.21 (d, J = 7.3 Hz, 2H), 7.14 (t, J = 7.4 Hz, 3H), 6.64 (d, J = 7.0 Hz, 2H), 3.81 (s, 6H), 3.27 (s, 4H), 2.51 (d, J = 9.7 Hz, 2H), 2.17 (s, 2H), 1.84 (t, J = 8.0 Hz, 2H), 1.59 - 1.50 (m, 2H), 1.44 (s, 2H); LC-MS (ESI) m/z 418.2 (M+H) ⁺ , RT = 1.852 minutes.

Example 100

({2-[(4-fluoro-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]et hyl}sulfanyl)acetic acid

[00813] Step 1 : 2-[(3-phenylpropyl)amino]ethan-l-ol hydrochloride

[00814] teri-Butyl (2-hydroxyethyl)(3-phenylpropyl)carbamate (1 g, 3.58 mmol, Accela ChemBio Co., Ltd) was added to 4 N HC1 in 1,4-dioxane (10 mL), and the mixture was stirred at room temperature overnight. Then the mixture was concentrated to dryness to give the titled compound (0.772 g, 3.58 mmol, 100% yield).

[00815] Step 2: 4-fluoro-N-(2-hydroxyethyl)-3,5-dimethoxy-N-(3-phenylpropyl) benzamide [00816] To a solution of 4-fluoro-3,5-dimethoxybenzoic acid (150 mg, 0.749 mmol) and 1- [bis(dimethylannno)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (313 mg, 0.824 mmol, HATU) in N,N-dimethylformamide (3 mL) was added triethylamine (0.115 mL 0.824 mmol). The resultant mixture was stirred at room temperature for 30 minutes. Then Example 100-Step 1 (162 mg, 0.749 mmol) in tetrahydrofuran (2.0 mL) and triethylamine (0.5 mL) was added. The mixture was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (50-100%) and then methanol (0-5%) in CH ₂ C1 ₂ to give the titled compound (127 mg, 0.351 mmol, 46.9% yield). LC-MS (ESI) m/z 362.2 (M+H) ⁺ , RT = 1.780 minutes.

[00817] Step 3: N-(2-chloroethyl)-4-fluoro-3,5-dimethoxy-N-(3-phenylpropyl)b enzamide

[00818] To a solution of Example 100-Step 2 (127 mg, 0.351 mmol) in CH ₂ C1 ₂ (2 mL) was added triethylamine (0.098 mL 0.703 mmol) and methanesulfonyl chloride (0.055 mL 0.703 mmol), sequentially. Then the solution was stirred at room temperature overnight. The solvent was removed under vacuum to give the titled compound. LC-MS (ESI) m/z 380.2 (M+H) ⁺ , RT = 2.008 minutes.

[00819] Step 4: ethyl ({2-[(4-fluoro-3,5-dimethoxybenzoyl)(3- phenylpropyl)amino]ethyl}sulfanyl)acetate

[00820] The mixture of Example 100-Step 3 was diluted with N,N-dimethylformamide (2 mL) followed by addition of potassium carbonate (194 mg, 1.404 mmol) and ethyl 2-mercaptoacetate (0.077 mL 0.702 mmol). The mixture was heated to 50 °C for 1 hour. Then the mixture was cooled down and diluted with water (10 mL) and extracted with ethyl acetate twice. The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-80%) to give the titled compound (56 mg, 0.100 mmol, 28.6% yield). LC-MS (ESI) m/z 464.2 (M+H) ⁺ , RT = 2.044 minutes.

[00821] Step 5: ({2-[(4-fluoro-3,5-dimethoxybenzoyl)(3- phenylpropyl)amino]ethyl}sulfanyl)acetic acid

[00822] To a solution of Example 100-Step 4 (56 mg, 0.121 mmol) in tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (0.725 mL 0.725 mmol). The mixture was stirred at room temperature for 1 hour. The mixture was acidified with 1 N HC1 to pH=2-3 and then extracted with ethyl acetate twice. The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H- H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (27.6 mg, 0.063 mmol, 52.5% yield). H NMR (400 MHz, DMSO-<¾) δ ppm 12.36 (s, 1H), 7.28 - 7.18 (m, 2H), 7.13 (t, J = 7.5 Hz, 3H), 6.68 (d, J = 7.0 Hz, 2H), 3.81 (s, 6H), 3.51 (s, 2H), 3.29 (s, 2H), 3.20 (s, 2H), 2.80 (t, J = 7.3 Hz, 2H), 2.50 (d, J = 5.2 Hz, 2H), 1.93 - 1.78 (m, 2H); LC-MS (ESI) m/z 436.2 (M+H) ⁺ , RT = 1.843 minutes.

Example 101

( { 2- [(3 , 5 -dimethoxybenzoyl) (3 -phenylpropyl) amino] ethyl } sulf anyl)acetic acid

[00823] Step 1 : N-(2-hydroxyethyl)-3,5-dimethoxy-N-(3-phenylpropyl)benzamide

[00824] To a solution of 3,5-dimethoxybenzoic acid (200 mg, 1.098 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (459 mg, 1.208 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.168 mL 1.208 mmol). The resultant solution was stirred at room temperature for 30 minutes. Then a solution of Example 100-Step 1 (237 mg, 1.098 mmol) in tetrahydrofuran (4 mL) and triethylamine (0.5 mL) was added. The mixture was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (50-100%) to give the titled compound (300 mg, 0.874 mmol, 80% yield). LC-MS (ESI) m/z 344.2 (M+H) ⁺ , RT = 1.783 minutes.

[00825] Step 2: N-(2-chloroethyl)-3,5-dimethoxy-N-(3-phenylpropyl)benzamide

[00826] To a solution of Example 101-Step 1 (300 mg, 0.874 mmol) in CH ₂ C1 ₂ (2 mL) was added triethylamine (0.244 mL 1.747 mmol) and methanesulfonyl chloride (0.136 mL 1.747 mmol), sequentially. Then the solution was stirred at room temperature overnight. The solvent was removed under vacuum to give the titled compound. LC-MS (ESI) m/z 362.2 (M+H) ⁺ , RT = 2.019 minutes.

[00827] Step 3: ethyl ({2-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]ethyl}sulfa nyl)acetate

[00828] To a solution of Example 101-Step 2 (156 mg, 0.431 mmol) in NN-dimethylformamide (2 mL) was added potassium carbonate (119 mg, 0.862 mmol) and ethyl 2-mercaptoacetate (0.095 mL 0.862 mmol). The mixture was heated to 50 °C for 1 hour. Then the mixture was cooled down and diluted with water (10 mL) and extracted with ethyl acetate twice. The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes(0~80%) to give the titled compound (125 mg, 0.281 mmol, 65.1% yield). LC-MS (ESI) m/z 446.2 (M+H) ⁺ , RT = 2.056 minutes.

[00829] Step 4: ({2-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]ethyl}sulfa nyl)acetic acid

[00830] To a solution of Example 101-Step 3 (125 mg, 0.281 mmol) in tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (1.683 mL 1.683 mmol). The mixture was stirred at room temperature for 1 hour. The mixture was acidified with 1 N HC1 to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H- H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (100 mg, 0.240 mmol, 85% yield). Ή

NMR (400 MHz, DMSO-<¾) δ ppm 12.36 (s, 1H), 7.23 (t, J = 7.4 Hz, 2H), 7.18 - 6.91 (m, 3H), 6.51 (t, J = 2.3 Hz, 1H), 6.42 (d, J = 2.3 Hz, 2H), 3.74 (s, 6H), 3.53 (d, J = 23.8 Hz, 2H), 3.29 (s, 2H), 3.15 (s, 2H), 2.78 (s, 2H), 2.50 (s, 2H), 1.84 (s, 2H); LC-MS (ESI) nt/z 418.2 (M+H) ⁺ , RT = 1.851 minutes.

Example 102

5- { [3 -(3-chlorophenyl)propyl] [ 1 -(4-methoxyphenyl)cyclopropane- 1 -carbonyl] amino jpentanoic acid

[00831] Step 1 : methyl 5-{ [3-(3-chlorophenyl)propyl] [l-(4-methoxyphenyl)cyclopropane-l- carbonyl] amino } pentanoate

[00832] To a solution of l-(4-methoxyphenyl)cyclopropanecarboxylic acid (237 mg, 1.233 mmol) and l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid

hexafluorophosphate (492 mg, 1.295 mmol, HATU) in N,N-dimethylformamide (8 mL) was added diisopropylethylamine (159 mg, 1.233 mmol). The resulting solution was stirred at room temperature for 5 minutes. Then Example 91 -Step 1 (350 mg, 1.233 mmol) was added in one portion. The solution was stirred at room temperature for 3 hours. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-100%) to give the titled compound (200 mg, 0.437 mmol, 35.5% yield). LC-MS (ESI) nt/z 458.2 (M+H) ⁺ , RT = 2.138 minutes.

[00833] Step 2: 5-{ [3-(3-chlorophenyl)propyl] [l-(4-methoxyphenyl)cyclopropane-l- carbonyl] amino jpentanoic acid

[00834] To a solution of Example 102-Step 1 (100 mg, 0.218 mmol) in 1 ,4-dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The mixture was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H-H ₂ 0/CH ₃ CN) to give the titled compound (26 mg, 0.059 mmol, 26.8% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.27 - 7.09 (m, 4H), 7.04 - 6.94 (m, 2H), 6.86 (dd, J = 11.1 , 8.4 Hz, 2H), 3.76 (s, 3H), 3.38 - 3.29 (m, 4H), 2.57 (t, J = 7.8 Hz, 1H), 2.38 - 2.26 (m, 2H), 2.07 (t, J = 7.3 Hz, 1H), 1.89 - 1.76 (m, 1H), 1.55 (h, J = 4.4, 3.8 Hz, 2H), 1.40 (p, J = 7.7 Hz, 1H), 1.33 - 1.24 (m, 2H), 1.24 - 1.17 (m, 1H), 1.17 - 1.05 (m, 2H), 1.02 - 0.95 (m, 1H); LC-MS (ESI) nt/z 444.2 (M+H) ⁺ , RT = 1.974 minutes.

Example 103

5-{ [l -(2-fluoro-4-methoxyphenyl)cyclopropane-l -carbonyl](3-phenylpropyl)amino}pentanoic acid

[00835] Step 1 : l-(2-fluoro-4-methoxyphenyl)cyclopropane-l-carbonitrile [00836] To a solution of 2-(2-fluoro-4-methoxyphenyl)acetonitrile (200 mg, 1.211 mmol) in N,N- dimethylformamide (1 mL) was added sodium hydride (60% in mineral oil) (145 mg, 3.63 mmol) at

0 °C under an atmosphere of nitrogen. The mixture was stirred at room temperature for 30 minutes. l-bromo-2-chloroethane (347 mg, 2.422 mmol) was added to the mixture at 0 °C. The reaction mixture was stirred at 30 °C for 3 hours. The mixture was cooled down to 0 °C and quenched with 1 Ν HC1. The mixture was extracted with ethyl acetate (2x20 mL), and the combined organic layers were washed with brine (2x20 mL), dried over Na ₂ S0 ₄ and concentrated. The residue was purified by silica flash column chromatography eluted with ethyl acetate in hexane from 0% to 50% over 20 minutes to give the titled compound (170 mg, 0.889 mmol, 73.4% yield). *H NMR (400 MHz, methanol-^) δ ppm 6.82 - 6.70 (m, 3H), 3.80 (d, J = 1.4 Hz, 3H), 1.65 - 1.58 (m, 2H), 1.38 - 1.32 (m, 2H); LC-MS (ESI) nt/z 192.2 (M+H) ⁺ , RT = 1.788 minutes.

[00837] Step 2: l-(2-fluoro-4-methoxyphenyl)cyclopropane-l-carboxylic acid

[00838] To a solution of Example 103-Step 1 (170 mg, 0.889 mmol) in ethanol (1 mL) was added 2 M KOH (1 mL 2.000 mmol). The mixture was heated to reflux and stirred for 16 hours. The mixture was cooled down and quenched with 1 N HC1 slowly. The mixture was extracted with ethyl acetate (2x20 mL), and the combined organic layers were dried over Na ₂ S0 ₄ and concentrated to give the titled compound (130 mg, 0.618 mmol, 69.6% yield). Ή NMR (400 MHz, methanol-^) δ ppm 6.74 - 6.60 (m, 3H), 3.78 (d, J = 1.0 Hz, 3H), 1.56 (q, J = 4.0 Hz, 2H), 1.14 (q, J = 4.0 Hz, 2H); LC- MS (ESI) nt/z 211.2 (M+H) ⁺ , RT = 1.659 minutes.

[00839] Step 3: methyl 5-{ [l -(2-fluoro-4-methoxyphenyl)cyclopropane-l -carbonyl](3- phenylpropyl) amino } pentanoate

[00840] To a solution of Example 103-Step 2 (29.5 mg, 0.140 mmol) in NN-dimethylformamide (1 mL) was added l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (56.0 mg, 0.147 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. Then Example 70-Step 1 (35 mg, 0.140 mmol) was added in one portion followed by the addition of diisopropylethylamine (0.049 mL 0.281 mmol). The solution was stirred at room temperature for 1 hour. The mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (30 mg, 0.068 mmol, 48.4% yield). LC-MS (ESI) nt/z 442 (M+H) ⁺ , RT = 2.092 minutes.

[00841] Step 4: 5-{ [l-(2-fluoro-4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid

[00842] To a solution of Example 103-Step 3 (30 mg, 0.068 mmol) in dioxane (0.5 mL) was added

1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The mixture was purified by preparative HPLC eluted with CH ₃ CN/H ₂ O/CF ₃ CO ₂ H to give the titled compound (20 mg, 0.047 mmol, 68.9% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.25 (t, J = 7.6 Hz, 2H), 7.16 (t, J = 6.8 Hz, 2H), 7.02 (d, J = 8.1 Hz, 2H), 6.70 (td, J = 17.0, 16.6, 9.3 Hz, 2H), 3.77 (d, J = 5.4 Hz, 3H), 3.39 - 3.32 (m, 2H), 3.25 (d, J = 7.1 Hz, 2H), 2.55 (dd, J = 9.2, 6.4 Hz, 1H), 2.29 (dt, J = 13.1, 7.0 Hz, 2H), 2.06 (t, J = 7.4 Hz, 1H), 1.85 - 1.76 (m, 1H), 1.51 (q, J = 4.2 Hz, 2H), 1.31 (td, J = 18.1, 16.0, 8.8 Hz, 4H), 1.16 (s, 1H), 1.07 (q, J = 4.4 Hz, 1H), 0.99 (s, 1H); LC-MS (ESI) m/z 428 (M+H) ⁺ , RT = 1.914 minutes.

Example 104

1 - { [N-(3 ,5-dimethoxy-4-methylbenzoyl)-N-(3 -phenylpropyl)glycyl] amino } -4-ethylcyclohexane- 1 - carboxylic acid

[00843] Step 1 : methyl [(3-phenylpropyl)amino]acetate

[00844] A mixture of methyl 2-chloroacetate (400 mg, 3.69 mmol), 3-phenylpropan-l-amine (498 mg, 3.69 mmol) and potassium carbonate (611 mg, 4.42 mmol) in CH ₃ CN (12 mL) was stirred at 50 °C overnight. The mixture was cooled down and filtered to give the titled compound. LC-MS (ESI) m/z 208.2 (M+H) ⁺ , RT = 1.380 minutes.

[00845] Step 2: methyl [(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]acetat e

[00846] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (724 mg, 3.69 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (1473 mg, 3.87 mmol, HATU) in N,N-dimethylformamide (20 mL) was added triethylamine (0.540 mL 3.87 mmol). The resulting solution was stirred at room temperature for 5 minutes. Then a solution of the material of Example 104-Step 1 was added in one portion. The solution was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-60%) to give the titled compound (640 mg, 1.660 mmol, 45.0% yield). LC-MS (ESI) m/z 386.2 (M+H) ⁺ , RT = 2.036 minutes.

[00847] Step 3: N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycine

[00848] To a solution of the material of Example 84-Step 2 (640 mg, 1.660 mmol) in 1,4-dioxane (4 mL) was added 1 Ν lithium hydroxide (4.98 mL 9.96 mmol). The solution was heated to 50 °C for 1.5 hours. The solution was acidified with 1 Ν HC1 to pH=2~3. It was extracted with ethyl acetate twice. The combined organic layers were washed with brine twice, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (634 mg, 1.707 mmol). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.77 (s, 1H), 7.26 (dt, J = 13.7, 7.3 Hz, 2H), 7.20 - 7.08 (m, 2H), 7.05 (d, J = 7.4 Hz, 1H), 6.51 (d, J = 3.0 Hz, 2H), 4.07 (s, 1H), 3.91 (s, 1H), 3.74 (d, J = 7.5 Hz, 6H), 3.43 (t, J = 7.7 Hz, 1H), 3.23 (t, J = 7.8 Hz, 1H), 2.61 (t, J = 7.9 Hz, 1H), 2.42 (t, J = 7.7 Hz, 1H), 1.98 (d, J = 10.2 Hz, 3H), 1.91 - 1.77 (m, 2H); LC-MS (ESI) nt/z 372.2 (M+H) ⁺ , RT = 1.897 minutes.

[00849] Step 4: methyl l-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] acetamido } -4-ethylcyclohexane- 1 -carboxylate

[00850] Example 104-Step 3 (52 mg, 0.14 mmol) and l-[bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5- ?]pyridinium 3-oxid hexafluorophosphate (58.6 mg, 0.154 mmol, HATU) was dissolved in a mixture of dry N,N-dimethylformamide (1 mL) and N,N-diisopropylethylamine (72.4 mg, 0.560 mmol). The mixture was stirred for 20 minutes at room temperature. Methyl l-amino-4- ethylcyclohexanecarboxylate hydrochloride (31.0 mg, 0.140 mmol) in N,N-dimethylformamide (1 mL) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (60 mg, 0.111 mmol, 80 % yield).

[00851] Step 5: l-{ [N-(3,5-dimethoxy-4-methylbenzoyl)-N-(3-phenylpropyl)glycyl] amino}-4- ethylcyclohexane-1 -carboxylic acid

[00852] To a solution of Example 104-Step 4 (60 mg, 0.111 mmol) in tetrahydrofuran (2 mL) was added aqueous lithium hydroxide solution (1.0 N, 0.70 mL). The mixture was stirred at room temperature for 3 hours. The mixture was acidified with 1 N hydrochloric acid to pH = 3 and then extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1 % CF ₃ CO ₂ H-H ₂ O/CH ₃ CN) and lyophilized to give the titled compound (45 mg, 0.086 mmol, 77% yield).

Example 105

5-{ [l-(3-fluoro-4-methoxyphenyl)cyclopropane-l-carbonyl](3-phen ylpropyl)amino}pentanoic acid

[00853] Step 1 : l-(3-fluoro-4-methoxyphenyl)cyclopropane-l-carbonitrile

[00854] To a solution of 2-(2-fluoro-4-methoxyphenyl)acetonitrile (200 mg, 1.211 mmol) in N,N- dimethylformamide (1 mL) was added sodium hydride (60% in mineral oil) (145 mg, 3.63 mmol) at 0 °C under an atmosphere of nitrogen. The mixture was stirred at room temperature for 30 minutes. l-Bromo-2-chloroethane (347 mg, 2.422 mmol) was added to the mixture at 0 °C. The reaction mixture was stirred at 30 °C for 3 hours. The mixture was cooled down to 0 °C and quenched with 1 Ν HC1. The mixture was extracted with ethyl acetate (2x20 mL), and the combined organic layer was washed with brine (2x20 mL), dried over Na ₂ S0 ₄ and concentrated. The residue was purified by silica gel flash column chromatography eluted with ethyl acetate in hexane from 0% to 50% over 20 minutes to give the titled compound (170 mg, 0.889 mmol, 73.4% yield). *H NMR (400 MHz, methanol-^) δ ppm 6.82 - 6.70 (m, 3H), 3.80 (d, J = 1.4 Hz, 3H), 1.65 - 1.58 (m, 2H), 1.38 - 1.32 (m, 2H); LC-MS (ESI) m/z 192 (M+H) ⁺ , RT = 1.788 minutes.

[00855] Step 2: l-(3-fluoro-4-methoxyphenyl)cyclopropane-l-carboxylic acid

[00856] To a solution of Example 105-Step 1 (170 mg, 0.889 mmol) in ethanol (1 mL) was added 2 M KOH (1 mL 2.000 mmol). The mixture was heated to reflux and stirred for 16 hours. The mixture was cooled down and quenched slowly with 1 N HC1. The mixture was extracted with ethyl acetate (2x20 mL), and the combined organic layer was dried over Na ₂ S0 ₄ and concentrated to give the titled compound (170 mg, 0.809 mmol, 91% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.12 - 6.95 (m, 3H), 3.85 (s, 3H), 1.54 (q, J = 3.9 Hz, 2H), 1.16 (q, J = 3.9 Hz, 2H); LC-MS (ESI) m/z 211 (M+H) ⁺ , RT = 1.650 minutes.

[00857] Step 3: methyl 5-{ [l-(3-fluoro-4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino } pentanoate

[00858] To a solution of Example 105-Step 2 (29.5 mg, 0.140 mmol) in NN-dimethylformamide (1 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyr idinium 3-oxid hexafluorophosphate (56.0 mg, 0.147 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 70-Step 1 (35 mg, 0.14 mmol) was added in one portion followed by the addition of diisopropylethylamine (0.049 mL 0.281 mmol). The solution was stirred at room temperature for 1 hour. The mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (50 mg, 0.113 mmol, 81% yield). LC-MS (ESI) m/z 442 (M+H) ⁺ , RT = 2.075 minutes.

[00859] Step 4: 5-{ [l-(3-fluoro-4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid

[00860] To a solution of Example 105-Step 3 (60 mg, 0.136 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The reaction mixture was purified by preparative HPLC eluting with CH ₃ CN/H ₂ O/CF ₃ CO ₂ H to give the titled compound (16 mg, 0.037 mmol, 27.5% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.31 - 6.90 (m, 8H), 6.88 - 6.79 (m, 1H), 3.78 (s, 3H), 3.20 (q, J = 9.6, 7.5 Hz, 4H), 2.28 (t, J = 7.9 Hz, 2H), 2.23 - 2.15 (m, 1H), 2.01 (t, J = 7.2 Hz, 1H), 1.72 (t, J = 8.1 Hz, 1H), 1.38 (d, J = 17.6 Hz, 4H), 1.25 - 1.07 (m, 4H), 0.94 (q, J = 4.7 Hz, 1H); LC-MS (ESI) m/z 428 (M+H) ⁺ , RT = 1.920 minutes.

Example 106

5-{ [l-(4-methoxyphenyl)cyclopentane-l-carbonyl](3-phenylpropyl) amino}pentanoic acid

[00861] Step 1 : methyl 5-{ [l-(4-methoxyphenyl)cyclopentane-l-carbonyl](3- phenylpropyl) amino } pentanoate [00862] To a solution of l-(4-methoxyphenyl)cyclopentanecarboxylic acid (38.0 mg, 0.172 mmol, Accela ChemBio Co., Ltd) in N,N-dimethylformamide (1 mL) was added 1-

[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (68.8 mg, 0.181 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. Then Example 70-Step 1 (43 mg, 0.172 mmol) in N,N-dimethylformamide (0.2 mL) was added in one portion followed by the addition of diisopropylethylamine (0.060 mL 0.345 mmol). The solution was stirred at room temperature for 1 hour. The mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (60 mg, 0.133 mmol, 77% yield). LC-MS (ESI) nt/z 452 (M+H) ⁺ , RT = 2.061 minutes.

[00863] Step 2: 5-{ [l-(4-methoxyphenyl)cyclopentane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid

[00864] To a solution of Example 106-Step 1 (60 mg, 0.133 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The mixture was purified by preparative HPLC eluting with CH ₃ CN/H ₂ O/CF ₃ CO ₂ H to give the titled compound (38 mg, 0.087 mmol, 65.4% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.30 - 7.10 (m, 5H), 7.03 - 6.99 (m, 1H), 6.98 - 6.94 (m, 1H), 6.91 - 6.84 (m, 2H), 3.77 (d, J = 1.9 Hz, 3H), 3.26 (m, 2H), 2.99 (dt, J = 12.8, 5.0 Hz, 2H), 2.59 (t, J = 7.8 Hz, 1H), 2.34 - 2.14 (m, 4H), 2.06 - 1.76 (m, 4H), 1.73 - 1.50 (m, 6H), 1.31 (dq, J = 11.6, 7.8 Hz, 1H), 1.13 (p, J = 7.5 Hz, 1H), 1.04 - 0.91 (m, 1H); LC-MS (ESI) nt/z 438 (M+H) ⁺ , RT = 1.898 minutes.

Example 107

5-{ [l-(3-chloro-4-methoxyphenyl)cyclopropane-l-carbonyl](3-phen ylpropyl)arnino}pentanoic acid

[00865] Step 1 : l-(3-chloro-4-methoxyphenyl)cyclopropane-l-carbonitrile

[00866] To a solution of 2-(3-chloro-4-methoxyphenyl)acetonitrile (300 mg, 1.652 mmol) in N,N- dimethylformamide (1 mL) was added sodium hydride (60% in mineral oil) (198 mg, 4.96 mmol) at 0 °C under an atmosphere of nitrogen. The mixture was stirred at room temperature for 30 minutes. l-Bromo-2-chloroethane (474 mg, 3.30 mmol) was added to the mixture at 0 °C. The reaction mixture was stirred at 30 °C for 3 hours. The mixture was cooled down to 0 °C and quenched with 1 Ν HC1. The mixture was extracted with ethyl acetate (2x20 mL), and the combined organic layers were washed with brine (2x20 mL), dried over Na ₂ S0 ₄ and concentrated. The residue was purified by silica gel flash column chromatography eluted with ethyl acetate in hexane from 0% to 50% over 20 minutes to give the titled compound (250 mg, 1.204 mmol, 72.9% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.34 (d, J = 2.4 Hz, 1H), 7.27 (dd, J = 8.6, 2.4 Hz, 1H), 7.06 (d, J = 8.6 Hz, 1H), 3.88 (s, 3H), 1.71 - 1.62 (m, 2H), 1.46 - 1.37 (m, 2H); LC-MS (ESI) m/z 208 (M+H) ⁺ , RT = 1.852 minutes. [00867] Step 2: l-(3-chloro-4-methoxyphenyl)cyclopropane-l-carboxylic acid

[00868] To a solution of Example 107-Step 1 (250 mg, 1.204 mmol) in ethanol (1 mL) was added 6 M KOH (1 mL, 6.00 mmol). The mixture was heated to 120 °C under microwave irradiation for 1.5 hours. The mixture was cooled down and slowly quenched with 1 N HCl. The mixture was extracted with ethyl acetate (2x20 mL), and the combined organic layers were dried over Na ₂ S0 ₄ and concentrated to give the titled compound (180 mg, 0.794 mmol, 66.0% yield). ¾ NMR (400 MHz, methanol-^) δ ppm 7.34 (d, J = 2.2 Hz, 1H), 7.23 (dd, J = 8.5, 2.2 Hz, 1H), 6.98 (d, J = 8.5 Hz, 1H), 3.86 (s, 3H), 1.55 (q, J = 4.0 Hz, 2H), 1.16 (q, J = 4.0 Hz, 2H); LC-MS (ESI) m/z 227 (M+H) ⁺ , RT = 1.701 minutes.

[00869] Step 3: methyl 5-{ [l-(3-chloro-4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino } pentanoate

[00870] To a solution of Example 107-Step 2 (45.4 mg, 0.201 mmol) in NN-dimethylformamide (2 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyr idinium 3-oxid hexafluorophosphate (80 mg, 0.211 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 70-Step 1 was added in one portion followed by the addition of diisopropylethylamine (0.070 mL 0.401 mmol). The solution was stirred at room temperature for 1 hour. The mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (60 mg, 0.131 mmol, 65.3% yield). LC-MS (ESI) m/z 458 (M+H) ⁺ , RT = 2.123 minutes.

[00871] Step 4: 5-{ [l-(3-chloro-4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid

[00872] To a solution of Example 107-Step 3 (60 mg, 0.131 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The mixture was purified by preparative HPLC eluting with CH ₃ CN/H ₂ O/CF ₃ CO ₂ H to give the titled compound (42 mg, 0.095 mmol, 72.2% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.31 - 7.11 (m, 5H), 7.10 - 6.95 (m, 4H), 3.85 (d, J = 3.8 Hz, 3H), 3.36 - 3.32 (m, 4H), 2.59 (t, J = 7.8 Hz, 1H), 2.34 (dt, J = 29.6, 7.0 Hz, 2H), 2.09 (t, J = 7.3 Hz, 1H), 1.85 (p, J = 7.7 Hz, 1H), 1.52 (ddt, J = 30.0, 8.1, 3.9 Hz, 4H), 1.35 - 1.27 (m, 1H), 1.23 - 1.09 (m, 3H), 0.99 - 0.91 (m, 1H); LC-MS (ESI) m/z 444 (M+H) ⁺ , RT = 1.963 minutes.

Example 108

5- [(3 ,5 -dimethoxybenzoyl)(3-phenylpropyl)amino] -2,2-dimethylpentanoic acid

[00873] Step 1 : methyl 5-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)amino]-2,2- dimethylpentanoate [00874] To a solution of diisopropylamine (0.197 mL, 1.385 mmol) in tetrahydrofuran (10 mL) was added butyllithium (0.811 mL, 1.298 mmol) at 0 °C under N ₂ atmosphere. The mixture was stirred at 0 °C for 15 minutes and then cooled to -78 °C. Then a solution of Example 98-Step 1 (370 mg, 0.865 mmol) in tetrahydrofuran (6 mL) was added to the mixture dropwise, and the mixture was stirred at -78 °C for 25 minutes. Then iodomethane (614 mg, 4.33 mmol) was added to the mixture with continued stirring at -78 °C to -30 °C over 2 hours. Aqueous NH ₄ C1 was added to the mixture, and the mixture was extracted with ethyl acetate (60 mL). The organic fraction was dried and concentrated. The residue was purified by chromatography on silica gel eluted with hexanes and ethyl acetate (from 0-50%) to give the titled compound (340 mg, 0.770 mmol, 89% yield). ¾ NMR (400 MHz, CDC1 ₃ ) δ ppm 7.25 (d, J = 12.0 Hz, 4H), 7.03 (d, J = 7.5 Hz, 1H), 6.56 - 6.37 (m, 3H), 3.79 (s, 6H), 3.69 - 3.56 (m, 3H), 3.47 (d, J = 23.6 Hz, 2H), 3.19 (d, J = 23.2 Hz, 2H), 2.70 (s, 1H), 2.44 (d, J = 7.8 Hz, 1H), 1.98 (s, 1H), 1.82 (s, 1H), 1.74 (s, 1H), 1.62 - 1.49 (m, 2H), 1.48 - 1.35 (m, 1H), 1.22 - 1.03 (m, 6H); LC-MS (ESI) m/z 442 (M+H) ⁺ , RT = 2.15 minutes.

[00875] Step 2: 5-[(3,5-dimethoxybenzoyl)(3-phenylpropyl)arnino]-2,2-dimethy lpentanoic acid

[00876] To a solution of Example 108-Step 1 (340 mg, 0.770 mmol) in 1,4-dioxane (5 mL) was added 1 N LiOH (7.70 mL 7.70 mmol), and the mixture was heated to 70 °C overnight. Then the mixture was cooled to room temperature and concentrated. The residue was diluted with water and washed with ethyl ether (20 mL). The aqueous layer was acidified with 1 N HC1 to pH = 2-3 and extracted with ethyl acetate (30 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by high pressure liquid chromatography eluted with acetonitrile and water (0.5% CF ₃ C0 ₂ H) to give the titled compound (242 mg, 0.566 mmol, 73.5% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.09 (s, 1H), 7.44 - 6.94 (m, 5H), 6.49 (d, J = 3.0 Hz, 1H), 6.38 (d, J = 2.3 Hz, 2H), 3.73 (s, 6H), 3.44 - 3.28 (m, 3H), 3.10 (t, J = 7.8 Hz, 2H), 2.61 (t, J = 7.6 Hz, 1H), 2.38 (t, J = 7.5 Hz, 1H), 1.81 (dt, J = 41.5, 7.8 Hz, 2H), 1.41 (d, J = 32.4 Hz, 4H), 1.26 - 1.14 (m, 1H), 1.04 (d, J = 35.0 Hz, 6H); LC-MS (ESI) m/z 428 (M+H) ⁺ , RT = 1.98 minutes.

Example 109

(2- { [3 -(3 -chlorophenyl)propyl] (3,5 -dimethoxy-4-methylbenzoyl) amino } ethoxy) acetic acid

[00877] Step 1 : N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-3-(3-chlorophenyl)prop an-l-amine

[00878] A mixture of (2-bromoethoxy)(teri-butyl)dimethylsilane (700 mg, 2.93 mmol), 3-(3- chlorophenyl)propan-l -amine (496 mg, 2.93 mmol), and potassium carbonate (485 mg, 3.51 mmol) in acetonitrile (6 mL) was refluxed for 16 hours. The mixture was cooled to room temperature and filtered to remove potassium carbonate to give the titled compound. LC-MS (ESI) m/z 328.2 (M+H) ⁺ , RT = 1.67 minutes.

[00879] Step 2: N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-N-[3-(3-chlorophenyl)p ropyl]-3,5- dimethoxy-4-methylbenzamide [00880] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (0.575 g, 2.93 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (1.170 g, 3.08 mmol, HATU) in NN-dimethylformamide (10 mL) was added triethylamine (0.429 mL 0.311 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 109-Step 1 (1.19 g, 1.451 mmol) in CH ₃ CN (10 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with saturated NaHC0 ₃ solution (10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was added to a silica gel column and was eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.5 g, 0.889 mmol, 61.3% yield). LC-MS (ESI) m/z 506.2 (M+H) ⁺ , RT = 2.50 minutes.

[00881] Step 3: ^-[3-(3-chlorophenyl)propyl]-^-(2-hydroxyethyl)-3,5-dimethox y-4- methylbenzamide

[00882] To a solution of Example 109-Step 2 (0.5 g, 0.988 mmol) in tetrahydrofuran (10 mL) was added tetra-«-butylammonium fluoride (0.310 g, 1.185 mmol). The reaction mixture was stirred at 20 °C for 1 hour. The mixture was concentrated, and the residue was dissolved in i-butyl methyl ether (10 mL). This mixture was washed with water (5 mL) and brine (5 mL), dried over Na ₂ S0 ₄ , filtered and concentrated to give the titled compound. LC-MS (ESI) m/z 392.2 (M+H) ⁺ , RT = 1.98 minutes.

[00883] Step 4: methyl (2-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetate

[00884] To a solution of Example 109-Step 3 (0.4 g, 1.021 mmol) in tetrahydrofuran (5 mL) was added methyl 2-chloroacetate (0.268 mL 3.06 mmol) and potassium teri-butoxide (0.344 g, 3.06 mmol) in one portion. The mixture was heated to reflux for 2 hours. The mixture was cooled down, quenched with saturated aqueous NH ₄ C1, and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (eluent:

hexanes:ethyl acetate from 100:0 to 50:50) to give the titled compound (0.15 g, 0.291 mmol, 28.5% yield). LC-MS (ESI) m/z 462.2 (M+H) ⁺ , RT = 2.11 minutes.

[00885] Step 5: (2-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid

[00886] To a solution of Example 109-Step 4 (0.15 g, 0.323 mmol) in tetrahydrofuran (4 mL) was added 1 N LiOH (1.940 mL 1.940 mmol). It was heated to 50 °C for 2 hours. The mixture was cooled down and acidified with 1 N HC1 to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were concentrated, and the residue was purified by preparative HPLC (0.1% aqueous ammonium bicarbonate/CH ₃ CN) and lyophilized to give the titled compound (55 mg, 0.120 mmol, 37.1% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.28 - 7.10 (m, 4H), 6.57 (s, 2H), 3.82 (m, 2H), 3.76 (s, 6H), 3.65 - 3.55 (m, 2H), 3.52 - 3.30 (m, 4H), 2.60 - 2.51 (m, 2H), 2.00 (s, 3H), 1.93 - 1.81 (m, 2H); LC-MS (ESI) m/z 450.2 (M+H) ⁺ , RT = 1.96 minutes.

Example 110

(2- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(2-fluorophenyl)propyl] amino } ethoxy)acetic acid

[00887] Step 1 : N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-3-(2-fluorophenyl)prop an-l-amine

[00888] In a 10 mL sealed tube, a mixture of (2-bromoethoxy)(teri-butyl)dimethylsilane (700 mg, 2.93 mmol), 3-(2-fluorophenyl)propan-l-amine (448 mg, 2.93 mmol), and potassium carbonate (485 mg, 3.51 mmol) in acetonitrile (6 mL) was stirred at reflux for 16 hours. The mixture was cooled to room temperature and filtered to remove potassium carbonate. The filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 312.2 (M+H) ⁺ , RT = 1.84 minutes.

[00889] Step 2: N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-N-[3-(2-fluorophenyl)p ropyl]-3,5- dimethoxy-4-methylbenzamide

[00890] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (0.510 g, 2.6 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.879 g, 2.311 mmol, HATU) in NN-dimethylformamide (10 mL) was added triethylamine (0.322 mL 2.311 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 110-Step 1 (1 g, 1.445 mmol) in CH ₃ CN (10 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with saturated NaHC0 ₃ solution (1x10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was added to a silica gel column which was eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.6 g, 1.103 mmol, 76% yield). LC-MS (ESI) m/z 490.2 (M+H) ⁺ , RT = 2.49 minutes.

[00891] Step 3: N-[3-(2-fluorophenyl)propyl]-N-(2-hydroxyethyl)-3,5-dimethox y-4- methylbenzamide

[00892] To a solution of Example 110-Step 2 (0.6 g, 1.225 mmol) in tetrahydrofuran (10 mL) was added tetra-«-butylammonium fluoride (0.320 g, 1.225 mmol). The reaction mixture was stirred at 20 °C for 1 hour. The mixture was concentrated, and the residue was dissolved in i-butyl methyl ether (10 mL). This mixture was washed with water (5 mL) and brine (5 mL), dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was used to the next step without further purification. LC-MS (ESI) m/z 376.2 (M+H) ⁺ , RT = 1.88 minutes.

[00893] Step 4: methyl (2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(2- fluorophenyl)propyl] amino } ethoxy) acetate

[00894] To a solution of Example 110-Step 3 (0.5 g, 1.332 mmol) in tetrahydrofuran (5 mL) was added methyl 2-chloroacetate (0.350 mL 4.00 mmol) and potassium teri-butoxide (0.448 g, 4.00 mmol) in one portion. The mixture was heated to reflux for 2 hours. The mixture was cooled down, quenched with saturated aqueous NH ₄ C1, and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (eluent:

hexanes:ethyl acetate from 100:0 to 50:50) to give the titled compound (0.15 g, 0.302 mmol, 22.65% yield). LC-MS (ESI) nt/z 448.2 (M+H) ⁺ , RT = 2.04 minutes.

[00895] Step 5: (2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(2- fluorophenyl)propyl] amino } ethoxy) acetic acid

[00896] To a solution of Example 110-Step 4 (0.15 g, 0.335 mmol) in tetrahydrofuran (4 mL) was added LiOH (0.048 g, 2.011 mmol). It was heated to 50 °C for 2 hours. The mixture was cooled down and acidified with 1 N HC1 to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were concentrated, and the residue was purified by preparative HPLC (0.1% aqueous ammonium bicarbonate/CH ₃ CN) and lyophilized to give the titled compound (68 mg, 0.154 mmol, 45.9% yield). 1H NMR (400 MHz, DMSO-<¾, T = 60 °C) d 7.23 - 7.03 (m, 4H), 6.65 (s, 2H), 3.81 (m, 2H), 3.75 (s, 6H), 3.64 - 3.52 (m, 2H), 3.50 - 3.35 (m, 4H), 2.60 - 2.52 (m, 2H), 1.99 (s, 3H), 1.90 - 1.80 (m, 2H); LC-MS (ESI) nt/z 434.2 (M+H) ⁺ , RT = 1.90 minutes.

Example 111

N- { 5-[(methanesulfonyl)amino] -5-oxopentyl } -3,5-dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide

[00897] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (100 mg, 0.242 mmol, Example 4) and Ι,Γ-carbonyldiimidazole (43.1 mg, 0.266 mmol), in isopropyl acetate (2 mL) was stirred at room temperature for 10 minutes. Methanesulfonamide (25.3 mg, 0.266 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (0.058 mL, 0.387 mmol) were added, and the reaction mixture was stirred at room temperature. At 2 hours, LC-MS showed formation of the titled compound and -5% of unreacted starting material. Ι,Γ-Carbonyldiimidazole (22 mg, 0.13 mmol) in isopropyl acetate (1 mL) was added to the reaction mixture, and the resultant mixture was stirred at room temperature for 10 minutes. Methanesulfonamide (13 mg, 0.13 mmol) and 1,8- diazabicyclo[5.4.0]undec-7-ene (0.029 mL, 0.194 mmol) were then added, and the reaction mixture was agitated in an ultrasonic bath for 2 minutes and stirred at 40 °C overnight. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 Ν HC1 and saturated NaCl, dried over MgS0 ₄ , and concentrated. The residue was re-dissolved in isopropyl acetate, 1,1'- carbonyldiimidazole (43.1 mg, 0.266 mmol) was added, and the mixture was stirred at 40 °C for 30 minutes. Then methanesulfonamide (25.3 mg, 0.266 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (0.058 mL, 0.387 mmol) were added. The reaction mixture was stirred at 50 °C overnight, and then the mixture was cooled to room temperature, diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 N HC1 and saturated NaCl, dried over MgS0 ₄ and concentrated. Flash chromatography (100% ethyl acetate) gave the titled compound (36 mg, 30%). Ή NMR (400 MHz, DMSO-<¾) δ ppm 1.54 (m, 4H), 1.82 (d, J = 26.6 Hz, 2H), 1.98 (s, 3H), 2.15 (s, 1H), 2.26 - 2.45 (m, 2H), 2.61 (d, J = 1.9 Hz, 1H), 3.19 (s, 5H), 3.37 (d, J = 2.7 Hz, 2H), 3.74 (s, 6H), 6.48 (s, 2H), 6.87 - 7.38 (m, 5H), 11.62 (s, 1H); MS (DCI) m/z 491 (M+H) ⁺ .

Example 112

[(2- { [3 -(2-chlorophenyl)propyl] (3,5 -dimethoxy-4-methylbenzoyl) amino } ethyl) sulf anyl] acetic acid

[00898] Step 1 : 3-(2-chlorophenyl)propanamide

[00899] A mixture of 3-(2-chlorophenyl)propanoic acid (2.0 g, 10.83 mmol) in thionyl chloride (10 mL, 137 mmol) was heated to reflux for 2 hours. Then the mixture was concentrated, the residue was dissolved in anhydrous tetrahydrofuran (30 mL), and the solution was cooled to 0 °C. Ammonia gas was bubbled into the system until pH >7. A solid was formed. Then the mixture was concentrated to give the titled compound (2.1 g, 10.29 mmol, 95% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.42 - 7.33 (m, 4H), 7.28 - 7.18 (m, 2H), 2.97 - 2.78 (m, 2H), 2.41 - 2.20 (m, 2H); LC-MS (ESI) m/z 184.0 (M+H) ⁺ , RT = 0.289 minutes.

[00900] Step 2: 3-(2-chlorophenyl)propan-l -amine

[00901] To a stirred solution of Example 112-Step 1 (2.1 g, 10.29 mmol) in tetrahydrofuran (60 mL) was added aluminum(III) lithium hydride (1.0 g, 26.3 mmol) in small portions at 0 °C. Then the reaction mixture was heated to reflux for 2 hours. Then the mixture was quenched with 3.0 g of Na ₂ SO ₄ ^» 10H ₂ O. To the mixture was added Mg ₂ S0 ₄ (5 g), and then the solid was removed by filtration. The filtrate was concentrated to give the titled compound (1.8 g, 8.49 mmol, 82% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.38 (dd, J = 7.7, 1.5 Hz, 1H), 7.32 (dd, J = 7.4, 1.9 Hz, 1H), 7.22 (dtd, J = 21.4, 7.4, 1.7 Hz, 2H), 2.73 - 2.62 (m, 2H), 2.54 (t, J = 6.9 Hz, 2H), 1.65 - 1.56 (m, 2H); LC-MS (ESI) m/z 172.2 (M+H) ⁺ , RT = 1.349 minutes.

[00902] Step 3: ethyl [(2-bromoethyl)sulfanyl]acetate

[00903] A mixture of ethyl 2-mercaptoacetate (10.0 g, 83 mmol), 1 ,2-dibromoethane (46.9 g, 250 mmol) and K ₂ C0 ₃ (34.5 g, 250 mmol) in acetonitrile (150 mL) was heated to reflux for 2 hours. Then the mixture was cooled to room temperature and filtered to remove solids. The filtrate was concentrated, and the residue was purified by chromatography on silica gel eluted with hexane and ethyl acetate (0-10%) to give the titled compound (14.0 g, 61.6 mmol, 74.1% yield).

[00904] Step 4: ethyl [(2- { [3 -(2-chlorophenyl)propyl] amino }ethyl)sulfanyl] acetate

[00905] A mixture of Example 112-Step 2 (250 mg, 1.474 mmol) and Example 112-Step 3 (335 mg, 1.474 mmol) in CH ₃ CN (3 mL) was stirred at reflux for 1 hour. The mixture was cooled to room temperature and filtered. The filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 316.2 (M+H) ⁺ , RT = 1.664 minutes. [00906] Step 5: ethyl [(2-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetate

[00907] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (289 mg, 1.474 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (617 mg, 1.621 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.226 mL 1.621 mmol). The resultant solution was stirred at room temperature for 30 minutes. Then it was added to a solution of Example 112-Step 4 (466 mg, 1.474 mmol) in CH ₃ CN (3 mL) and

triethylamine (0.5 mL). The mixture was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-35%) to give the titled compound (90 mg, 0.118 mmol, 8.03% yield). LC-MS (ESI) m/z 494.2 (M+H) ⁺ , RT = 2.193 minutes.

[00908] Step 6: 2-((2-(N-(3-(2-chlorophenyl)propyl)-3,5-dimethoxy-4- methylbenzamido)ethyl)thio)acetic acid

[00909] To a solution of Example 112-Step 5 (90 mg, 0.182 mmol) in tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (1.093 mL 1.093 mmol). The mixture was stirred at room temperature for 2 hours. The solution was concentrated under reduced pressure to remove most of the

tetrahydrofuran. A solid precipitated from the aqueous mixture. The solids were collected by filtration and washed with water and hexanes to give the lithium salt of the titled compound. The salt was treated with 1 N HC1 (4 mL) under ultra-sonic treatment. The solid was then collected by filtration and washed with water and hexanes to give the titled compound (42 mg, 0.090 mmol, 49.5% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.36 (s, 1H), 7.34 (d, J = 7.1 Hz, 1H), 7.31 - 7.14 (m, 3H), 6.52 (s, 2H), 3.76(s, 6H), 3.53 (s, 2H), 3.36 (s, 2H), 3.21 (s, 2H), 2.81 (t, J = 7.4 Hz, 2H), 2.62 (s, 2H), 2.00 (s, 3H), 1.91 - 1.79 (m, 2H); LC-MS (ESI) m/z 466.2 (M+H) ⁺ , RT = 1.988 minutes.

Example 113

[(2-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}ethyl)sulfanyl]acetic acid

[00910] Step 1 : 3-(2,6-difluorophenyl)propanamide

[00911] A solution of 3-(2,6-difluorophenyl)propanoic acid (2.0 g, 10.74 mmol) in thionyl chloride (10 mL, 137 mmol) was heated to reflux for 2 hours. Then the mixture was concentrated, the residue was dissolved in anhydrous tetrahydrofuran (30 mL), and the solution was cooled to 0 °C. Ammonia gas was bubbled into the system till pH >7, and a solid formed. Then the mixture was concentrated to give the titled compound (2.094 g, 10.74 mmol, 100% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.24 (tt, J = 8.4, 6.5 Hz, 1H), 6.98 - 6.86 (m, 2H), 3.02 - 2.93 (m, 2H), 2.52 - 2.43 (m, 2H); LC- MS (ESI) m/z 186.2 (M+H) ⁺ , RT = 1.414 minutes. [00912] Step 2: 3-(2,6-difluorophenyl)propan-l -amine

[00913] To a solution of Example 113-Step 1 (2.1 g, 11.34 mmol) in tetrahydrofuran (60 mL) was added aluminum(III) lithium hydride (1.0 g, 26.3 mmol) in small portions at 0 °C. Then the reaction mixture was heated to reflux for 2 hours. Then the mixture was quenched with 3.0 g of

Na ₂ SO ₄ ^» 10H ₂ O. To the mixture was added Mg ₂ S0 ₄ (5 g), and then the solids were removed by filtration. The filtrate was concentrated to give the titled compound (1.76 g, 8.22 mmol, 72.5% yield). *H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.17 - 7.09 (m, 1H), 6.88 - 6.78 (m, 2H), 2.86 - 2.63 (m, 4H), 1.79 (h, J = 7.4, 6.8 Hz, 2H); LC-MS (ESI) m/z 172.2 (M+H) ⁺ , RT = 1.181 minutes.

[00914] Step 3: ethyl [(2- { [3 -(2,6-difluorophenyl)propyl] amino }ethyl)sulfanyl] acetate

[00915] A mixture of Example 113-Step 2 (250 mg, 1.460 mmol) and Example 112-Step 3 (332 mg, 1.460 mmol) in CH ₃ CN (3 mL) was stirred at reflux for 1.5 hours. Then the solution was cooled down to give the titled compound. LC-MS (ESI) m/z 318.2 (M+H) ⁺ , RT = 1.606 minutes.

[00916] Step 4: ethyl [(2-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetate

[00917] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (286 mg, 1.460 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (611 mg, 1.606 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.224 mL 1.606 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 113-Step 3 (463 mg, 1.460 mmol) and triethylamine (0.5 mL) in CH ₃ CN (3 mL) was added into the mixture. The mixture was stirred at room temperature for 2 hours. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-35%) to give the titled compound (330 mg, 0.360 mmol, 24.63% yield). LC-MS (ESI) m/z 496.2 (M+H) ⁺ , RT = 2.147 minutes.

[00918] Step 5: [(2-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetic acid

[00919] To a solution of Example 113-Step 4 (330 mg, 0.666 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (4.00 mL 4.00 mmol). The mixture was stirred at room temperature for 2 hours. The solution was concentrated under reduced pressure to remove most of the tetrahydrofuran. A solid precipitated which was collected by filtration and washed with water and hexanes to give the lithium salt of the titled compound. The salt was treated with 1 N HC1 (4 mL) under ultra-sonic treatment. Then the solid was collected by filtration and washed with water and hexanes. This solid was dissolved in tetrahydrofuran (2 mL) and purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H- H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (147 mg, 0.314 mmol, 47.2% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.32 - 7.17 (m, 1H), 6.95 (t, J = 7.9 Hz, 2H), 6.48 (s, 2H), 3.74 (s, 6H), 3.51 (s, 2H), 3.31 (s, 2H), 3.20 (s, 2H), 2.88 - 2.75 (m, 2H), 2.50 (s, 2H), 1.98 (s, 3H), 1.80 (dt, J = 15.3, 7.4 Hz, 2H); LC-MS (ESI) nt/z 468.2 (M+H) ⁺ , RT = 1.951 minutes.

Example 114

[(2-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}ethyl)sulfanyl]acetic acid

[00920] Step 1 : 3-(2,4-difluorophenyl)propanamide

[00921] A solution of 3-(2,4-difluorophenyl)propanoic acid (1.0 g, 5.37 mmol) in thionyl chloride (10 mL, 137 mmol) was heated at reflux for 2 hours. The mixture was then concentrated, the residue was dissolved in anhydrous tetrahydrofuran (30 mL), and the solution was cooled to 0 °C. Ammonia gas was bubbled in until pH >7 producing a solid. Then the mixture was concentrated to give the titled compound (1.047 g, 5.37 mmol, 100% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.29 (td, J = 8.8, 6.4 Hz, 1H), 7.00 - 6.71 (m, 2H), 2.92 (t, J = 7.7 Hz, 2H), 2.61 - 2.34 (m, 2H); LC-MS (ESI) nt/z 186.0 (M+H) ⁺ , RT = 1.471 minutes.

[00922] Step 2: 3-(2,4-difluorophenyl)propan-l -amine

[00923] To a solution of Example 114-Step 1 (1.045 g, 5.64 mmol) in tetrahydrofuran (60 mL) was added aluminum(III) lithium hydride (1.0 g, 26.3 mmol) in small portions at 0 °C. Then the reaction mixture was heated at reflux for 2 hours. Then the mixture was quenched with 3.0 g of Na ₂ S0 ₄ . To the mixture was added 5 g of Mg ₂ S0 ₄ , and then the solids were removed by filtration. The solution was concentrated to give the titled compound (800 mg, 3.74 mmol, 66.2% yield).

NMR (400 MHz, CDC1 ₃ ) δ ppm 7.19 - 7.06 (m, 1H), 6.89 - 6.66 (m, 2H), 2.77 (t, J = 7.1 Hz, 2H), 2.65 (q, J = 7.9 Hz, 2H), 1.79 (q, J = 7.4 Hz, 2H); LC-MS (ESI) nt/z 172.2 (M+H) ⁺ , RT = 1.215 minutes.

[00924] Step 3: ethyl [(2- { [3 -(2,4-difluorophenyl)propyl] amino }ethyl)sulfanyl] acetate

[00925] A mixture of Example 114-Step 2 (210 mg, 1.227 mmol) and Example 112-Step 3 (279 mg, 1.227 mmol) in CH ₃ CN (3 mL) was stirred at reflux for 1.5 hours to give the titled compound. LC-MS (ESI) nt/z 318.2 (M+H) ⁺ , RT = 1.604 minutes.

[00926] Step 4: ethyl [(2-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetate

[00927] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (241 mg, 1.227 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (513 mg, 1.350 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.188 mL 1.350 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 114-Step 3 (389 mg, 1.227 mmol) and triethylamine (0.5 mL) in CH ₃ CN (3.0 mL) was added. The mixture was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-35%) to give the titled compound (320 mg, 0.258 mmol, 21.05% yield). LC-MS (ESI) m/z 496.2 (M+H) ⁺ , RT = 2.148 minutes.

[00928] Step 5: [(2-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetic acid

[00929] To a solution of Example 114-Step 4 (320 mg, 0.646 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (3.87 mL 3.87 mmol). The mixture was stirred at room temperature for 2 hours. The solution was concentrated under reduced pressure to remove most of the tetrahydrofuran. A solid precipitated which was collected by filtration. The solid was washed with water and hexanes to give the lithium salt of the target molecule. The salt was treated with 1 N HC1 (4 mL) under ultrasonic treatment. The solid was collected by filtration and washed with water and hexanes. This solid was dissolved in 2 mL of tetrahydrofuran and purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H- H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (103 mg, 0.220 mmol, 34.1 % yield). Ή NMR (400 MHz, DMSO-<¾) δ ppm 7.23 (s, 1H), 7.09 - 6.98 (m, 1H), 6.90 (t, J = 8.1 Hz, 1H), 6.49 (s, 2H), 3.75 (s, 6H), 3.51 (s, 2H), 3.30 (s, 2H), 3.20 (s, 2H), 2.81 (t, J = 7.5 Hz, 2H), 2.49 (d, J = 1.9 Hz, 2H), 1.99 (s, 3H), 1.89 - 1.76 (m, 2H); LC-MS (ESI) m/z 468.2 (M+H) ⁺ , RT = 1.959 minutes.

Example 115

[(2- { [ 1 -(4-methoxyphenyl)cyclopropane- 1 -carbonyl] (3 -phenylpropyl) amino } ethyl)sulf anyl] acetic acid

[00930] Stepl : ethyl ({2-[(3-phenylpropyl)amino]ethyl}sulfanyl)acetate

[00931] A mixture of 3-phenylpropan-l -amine (170 mg, 1.257 mmol) and ethyl [(2- bromoethyl)sulf anyl] acetate (286 mg, 1.257 mmol, Example 132-Step 4) in CH ₃ CN (6 mL) was stirred at reflux for 3 hours. Then the mixture was cooled down and filtered, the filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 2S2 (M+H) ⁺ , RT = 1.754 minutes

[00932] Step 2: ethyl [(2-{ [l -(4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl)amino}ethyl)sulfanyl]acetate

[00933] To a solution of l-(4-methoxyphenyl)cyclopropanecarboxylic acid (239 mg, 1.244 mmol) in N,N-dimethylformamide (3 mL) was added l-[bis(dimethylamino)methylene]-lH- 1 ,2,3 - triazolo[4,5- ?]pyridinium 3-oxid hexafluorophosphate (497 mg, 1.306 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. A solution of ethyl ({2-[(3- phenylpropyl)amino]ethyl}sulfanyl)acetate (350 mg, 1.244 mmol, Example 115-Step 1) in N,N- dimethylformamide (1.0 mL) was added in one portion followed by the addition of

diisopropylethylamine (0.434 mL 2.487 mmol). The solution was stirred at room temperature for 1 hour. The reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.15 g, 0.329 mmol, 26.5% yield). LC-MS (ESI) m/z 456 (M+H) ⁺ , RT = 2.12 minutes.

[00934] Step 3: [(2-{ [l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl)amino}ethyl)sulfanyl]acetic acid

[00935] To a solution of Example 115-Step 2 (0.15 g, 0.329 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The pH of the mixture was adjusted to about 6-7 and purified by preparative HPLC eluting with

CH ₃ CN/H ₂ O/CF ₃ CO ₂ H to give the titled compound (60 mg, 0.140 mmol, 42.6% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.28 - 7.13 (m, 4H), 7.07 - 6.97 (m, 3H), 6.86 (dd, J = 15.8, 8.5 Hz, 2H), 3.76 (s, 3H), 3.61 - 3.47 (m, 2H), 3.41 - 3.32 (m, 2H), 3.25 (s, 1H), 3.02 (s, 1H), 2.79 (dd, J = 8.2, 6.2 Hz, 1H), 2.58 (t, J = 7.7 Hz, 1H), 2.34 (t, J = 7.5 Hz, 1H), 2.26 (t, J = 8.1 Hz, 1H), 1.85 (p, J = 7.8 Hz, 1H), 1.49 - 1.39 (m, 1H), 1.34 - 1.11 (m, 3H), 0.98 (q, J = 4.6 Hz, 1H); LC-MS (ESI) m/z 428 (M+H) ⁺ , RT = 1.928 minutes.

Example 116

[(2- { (3 , 5 -dimethoxy-4-methylbenzoyl) [3 -(2-fluorophenyl)propyl] amino } ethyl)sulf anyl] acetic acid

[00936] Step 1 : ethyl [(2- { [3 -(2-fluorophenyl)propyl] amino }ethyl)sulfanyl] acetate

[00937] A mixture of 3-(2-fluorophenyl)propan-l -amine (300 mg, 1.958 mmol) and Example 112- Step 3 (445 mg, 1.958 mmol) in CH ₃ CN (2 mL) was stirred at reflux for 2 hours. The mixture was cooled and concentrated to give the titled compound. LC-MS (ESI) m/z 300 (M+H) ⁺ , RT = 1.593 minutes.

[00938] Step 2: ethyl [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(2- fluorophenyl)propyl] amino } ethyl) sulf anyl] acetate

[00939] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (360 mg, 1.837 mmol) in N,N- dimethylformamide (3 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (733 mg, 1.929 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. A solution of Example 116-Step 1 (550 mg, 1.837 mmol) in N,N-dimethylformamide (1.0 mL) was added in one portion followed by the addition of diisopropylethylamine (0.642 mL 3.67 mmol). The solution was stirred at room temperature for 1 hour. The mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.2 g, 0.419 mmol, 22.80% yield). LC-MS (ESI) m/z 479 (M+H) ⁺ , RT = 2.149 minutes. [00940] Step 3: [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(2- fluorophenyl)propyl] amino } ethyl) sulf anyl] acetic acid

[00941] To a solution of Example 116-Step 2 (0.2 g, 0.419 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The mixture was adjusted to pH about 6-7 and purified by preparative HPLC eluting with CH ₃ CN/H ₂ O/CF ₃ CO ₂ H to give the titled compound (65 mg, 0.145 mmol, 34.5% yield). ¾ NMR (400 MHz, methanol-^) δ ppm 7.39 - 6.86 (m, 4H), 6.53 (d, J = 44.2 Hz, 2H), 3.80 (d, J = 19.1 Hz, 8H), 3.64 - 3.45 (m, 2H), 3.40 - 3.32 (m, 2H), 2.95 (d, J = 6.8 Hz, 2H), 2.80 - 2.72 (m, 1H), 2.54 - 2.46 (m, 1H), 2.04 (s, 4H), 1.88 (dd, J = 14.2, 7.2 Hz, 1H); LC-MS (ESI) m/z 450 (M+H) ⁺ , RT = 1.942 minutes.

Example 117

[(2- { (3 , 5 -dimethoxy-4-methylbenzoyl) [3 -(3 -fluorophenyl)propyl] amino } ethyl)sulf anyl] acetic acid

[00942] Step 1 : ethyl [(2-{ [3-(3-fluorophenyl)propyl]arnino}ethyl)sulfanyl]acetate

[00943] A mixture of 3-(3-fluorophenyl)propan-l-amine (300 mg, 1.958 mmol) and Example 112- Step 3 (445 mg, 1.958 mmol) in CH ₃ CN (2 mL) was stirred at reflux for 3 hours. The mixture was cooled down and concentrated to give the titled compound. LC-MS (ESI) m/z 300 (M+H) ⁺ , RT = 1.537 minutes.

[00944] Step 2: ethyl [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(3- fluorophenyl)propyl] amino } ethyl) sulf anyl] acetate

[00945] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (360 mg, 1.837 mmol) in N,N- dimethylformamide (3 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- Z?]pyridinium 3-oxid hexafluorophosphate (733 mg, 1.929 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. A solution of Example 117-Step 1 (550 mg, 1.837 mmol) in N,N-dimethylformamide (1.0 mL) was added in one portion followed by the addition of diisopropylethylamine (0.642 mL 3.67 mmol). The solution was stirred at room temperature for 1 hour. The mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.2 g, 0.419 mmol, 22.80% yield). LC-MS (ESI) m/z 478 (M+H) ⁺ , RT = 2.145 minutes.

[00946] Step 3: [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(3- fluorophenyl)propyl] amino } ethyl) sulf anyl] acetic acid

[00947] To a solution of Example 117-Step 2 (0.2 g, 0.419 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The mixture was adjusted to pH about 6-7 and then purified by preparative HPLC eluting with

CH ₃ CN/H ₂ 0/CF ₃ C0 ₂ H to give the titled compound (0.14 g, 0.311 mmol, 74.4% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.33 - 6.67 (m, 4H), 6.53 (d, J = 31.8 Hz, 2H), 3.80 (d, J = 18.9 Hz, 8H), 3.64 - 3.44 (m, 2H), 3.33 (d, J = 2.9 Hz, 2H), 2.95 (d, J = 7.6 Hz, 2H), 2.75 (d, J = 28.1 Hz, 1H), 2.47 (d, J = 7.6 Hz, 1H), 2.05 (s, 4H), 1.94 - 1.83 (m, 1H); LC-MS (ESI) m/z 450 (M+H) ⁺ , RT = 1.95 minutes.

Example 118

[(2- { (3 , 5 -dimethoxy-4-methylbenzoyl) [3 -(4-fluorophenyl)propyl] amino } ethyl)sulf anyl] acetic acid

[00948] Step 1 : ethyl [(2- { [3 -(4-fluorophenyl)propyl] amino }ethyl)sulfanyl] acetate

[00949] A mixture of 3-(4-fluorophenyl)propan-l -amine (300 mg, 1.958 mmol) and Example 112- Step 3 (445 mg, 1.958 mmol) in CH ₃ CN (2 mL) was stirred at reflux for 3 hours. The mixture was cooled down and concentrated to give the titled compound. LC-MS (ESI) m/z 300 (M+H) ⁺ , RT = 1.576 minutes.

[00950] Step 2: ethyl [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4- fluorophenyl)propyl] amino } ethyl) sulf anyl] acetate

[00951] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (360 mg, 1.837 mmol) in N,N- dimethylformamide (3 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (733 mg, 1.929 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. A solution of Example 118-Step 1 (550 mg, 1.837 mmol) in N,N-dimethylformamide (1.0 mL) was added in one portion followed by the addition of diisopropylethylamine (0.642 mL 3.67 mmol). The solution was stirred at room temperature for 1 hour. The mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.2 g, 0.419 mmol, 22.80% yield). LC-MS (ESI) m/z 478 (M+H) ⁺ , RT = 2.144 minutes.

[00952] Step 3: [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4- fluorophenyl)propyl] amino } ethyl) sulf anyl] acetic acid

[00953] To a solution of Example 118-Step 2 (0.2 g, 0.419 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The mixture pH was adjusted to about 6-7 and then purified by preparative HPLC eluting with

CH ₃ CN/H ₂ 0/CF ₃ C0 ₂ H to give the titled compound (70 mg, 0.156 mmol, 37.2% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.26 (s, 1H), 7.07 - 6.79 (m, 3H), 6.52 (d, J = 33.8 Hz, 2H), 3.79 (d, J = 13.7 Hz, 8H), 3.59 - 3.45 (m, 2H), 3.42 - 3.31 (m, 2H), 2.94 (d, J = 7.7 Hz, 2H), 2.74 (d, J = 37.0 Hz, 1H), 2.45 (t, J = 6.8 Hz, 1H), 2.05 (s, 4H), 1.86 (q, J = 7.7, 6.5 Hz, 1H); LC-MS (ESI) m/z 450 (M+H) ⁺ , RT = 1.943 minutes. Example 119

N-{54 _L (cyclopropanesulfonyl)amino]-5-oxopentyl}-3,5-dimethox y-4-methyl-N-(3- phenylpropyl)benzamide

[00954] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (100 mg, 0.242 mmol, Example 4) and Ι,Γ-carbonyldiimidazole (58.8 mg, 0.363 mmol) in isopropyl acetate (2 mL) was stirred at 40 °C for 10 minutes, and then cyclopropanesulfonamide (32.2 mg, 0.266 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (72.9 μΕ, 0.484 mmol) were added. The reaction mixture was stirred at 40 °C for 18 hours. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 N HC1 and saturated NaCl, dried over MgS0 ₄ and

concentrated. Flash chromatography (100% ethyl acetate) gave the titled compound (76 mg) that was contaminated with a small amount of starting acid. This material was redissolved in isopropyl acetate (2 mL); Ι,Γ-carbonyldiimidazole (30 mg), l,8-diazabicyclo[5.4.0]undec-7-ene (0.04 mL) and cyclopropane sulfonamide (25 mg) were added; and the resultant mixture was stirred at 50 °C for 48 hours. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 N HC1 and saturated NaCl, dried over MgS0 ₄ and concentrated. Flash chromatography (100% ethyl acetate) gave the titled compound (55 mg, 44%). *H NMR (400 MHz, DMSO-<¾) δ ppm 0.69 - 0.90 (m, 2H), 1.03 (t, / = 6.4 Hz, 4H), 1.22 (s, 2H), 1.54 (s, 3H), 1.82 (s, 2H), 2.07 - 2.42 (m, 3H), 2.61 (s, 1H), 2.90 (s, 1H), 3.15 (s, 2H), 3.37 (s, 2H), 3.74 (s, 6H), 6.48 (s, 2H), 6.88 - 7.53 (m, 5H), 11.57 (s, 1H); MS (DCI) m/z 517 (M+H) ⁺ .

Example 120

(4R)-5 -[(3,5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl)amino] -4-hydroxypentanoic acid

[00955] Step 1 : ethyl (4R)-4-{ [teri-butyl(dimethyl)silyl]oxy}-5-[(3- phenylpropyl) amino] pentanoate

[00956] To a solution of (25,4R)-ethyl 4-((teri-butyldimethylsilyl)oxy)-l-(3- phenylpropyl)pyrrolidine-2-carboxylate (0.1 g, 0.255 mmol, Accela ChemBio Co., Ltd), HMPA (0.222 mL 1.277 mmol), and tetrahydrofuran (2 mL) were added dropwise samarium(II) iodide (2.043 mL 2.043 mmol) and pivalic acid (0.074 mL 0.638 mmol) in tetrahydrofuran (1 mL) at 0 °C. The resulting solution was allowed to warm to room temperature. A stream of air was bubbled through the solution, and an excess of diatomaceous earth in diethyl ether and saturated aqueous NaHC0 ₃ (1 mL) were added. The mixture was filtered, and the filtrate was washed with brine. The organic layer was separated, dried and concentrated to give the titled compound. LC-MS (ESI) m/z 394.2 (M+H) ⁺ , RT = 1.99 minutes.

[00957] Step 2: ethyl (4R)-4-{ [teri-butyl(dimethyl)silyl]oxy}-5-[(3,5-dimethoxy-4- methylbenzoyl)(3-phenylpropyl)amino]pentanoate [00958] A mixture of 3,5-dimethoxy-4-methylbenzoic acid (0.025 g, 0.127 mmol), Example 120- Step 1 (50 mg, 0.079 mmol, 62.0% yield), 2-(3H-[l,2,3]triazolo[4,5 ]pyridin-3-yl)-l, 1,3,3- tetramethylisouronium hexafluorophosphate(V) (0.048 g, 0.127 mmol), N-ethyl-N-isopropylpropan-2- amine (0.022 mL 0.127 mmol) and N,N-dimethylformamide (1 mL) was stirred at room temperature for 1 hour. The mixture was extracted with ethyl acetate (3x20 mL). The organic layer was combined, washed with brine, dried with Na ₂ S0 ₄ , filtered and concentrated to dryness. The residue was purified by flash column (eluent, ethyl acetate/hexane from 0/100 to 20/80) to give the titled compound. ^l U NMR (400 MHz, CDC1 ₃ ) δ ppm 7.34 - 7.26 (m, 1H), 7.26 - 7.10 (m, 3H), 6.98 (d, J = 7.3 Hz, 1H), 6.51 (s, 2H), 4.26 - 3.97 (m, 3H), 3.80 (d, J = 5.3 Hz, 6H), 3.68 - 3.11 (m, 4H), 2.84 - 2.28 (m, 4H), 2.09 (s, 3H), 2.02 - 1.62 (m, 4H), 1.29 - 1.19 (m, 3H), 0.96 - 0.79 (m, 9H), 0.18 - -0.12 (m, 6H); LC-MS (ESI) m/z 572.4 (M+H) ⁺ , RT = 2.497 minutes.

[00959] Step 3: ethyl (4R)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino ]-4- hydroxypentanoate

[00960] A mixture of Example 120-Step 2 (80 mg, 0.140 mmol) and tetra-«-butylammonium fluoride (54.9 mg, 0.210 mmol) in tetrahydrofuran (2 mL) was stirred at room temperature for 1 hour. The mixture was extracted with ethyl acetate (3x20 mL). The organic layers were combined, washed with brine, dried with Na ₂ S0 ₄ , filtered and concentrated to dryness. The residue was purified by flash column chromatography on silica gel (eluent, ethyl acetate/hexane from 0/100 to 40/60) to give the titled compound. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.25 - 7.12 (m, 3H), 7.01 (s, 2H), 6.49 (d, J = 12.1 Hz, 2H), 4.14 (q, J = 7.1 Hz, 2H), 3.95 (d, J = 14.6 Hz, 1H), 3.79 (s, 7H), 3.67 - 3.54 (m, 1H), 3.44 - 3.13 (m, 3H), 2.50 (d, J = 13.9 Hz, 4H), 2.10 (s, 3H), 1.89 (s, 4H), 1.31 - 1.22 (m, 3H); LC-MS (ESI) m/z 572.4 (M+H) ⁺ , RT = 2.497 minutes.

[00961] Step 4: (4R)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino ]-4- hydroxypentanoic acid

[00962] A mixture of Example 120-Step 3 (50 mg, 0.109 mmol), lithium hydroxide hydrate (9.17 mg, 0.219 mmol), water (1 mL) and 1,4-dioxane (1 mL) was stirred at 40 °C for 2 hours. The mixture was acidified to pH =4 with 1 N HC1. The clear solution was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H as buffer). 90% of the material was eliminated to give Example 121. The mixture was purified again by preparative HPLC (ammonium acetate as buffer) to afford the titled compound and Example 121. *H NMR (400 MHz, methanol-^) δ ppm 7.31 - 7.04 (m, 4H), 6.95 (d, J = 7.2 Hz, 1H), 6.69 (s, 1H), 6.54 (s, 1H), 3.96 (s, 1H), 3.80 (d, J = 17.7 Hz, 6H), 3.63 (d, J = 15.0 Hz, 1H), 3.45 - 3.35 (m, 2H), 2.70 (t, J = 7.7 Hz, 1H), 2.40 (dt, J = 26.1, 7.4 Hz, 2H), 2.20 (d, J = 7.4 Hz, 1H), 2.05 (d, J = 4.5 Hz, 3H), 1.95 - 1.78 (m, 2H), 1.77 - 1.66 (m, 1H), 1.58 (s, 1H), 1.46 (s, 1H); LC-MS (ESI) m/z 430.2 (M+H) ⁺ , RT = 1.844 minutes. Example 121

(3E)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino ]pent-3-enoic acid

[00963] See Example 120 for details. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.29 - 6.91 (m, 5H), 6.48 (d, J = 8.7 Hz, 2H), 4.91 (d, J = 10.5 Hz, 1H), 4.03 (dd, J = 68.0, 16.1 Hz, 1H), 3.79 (s, 6H), 3.53

- 3.13 (m, 3H), 2.62 - 2.37 (m, 4H), 2.10 (s, 3H); LC-MS (ESI) m/z 412.2 (M+H) ⁺ , RT = 1.975 minutes.

Example 122

[(2-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl)ami no}ethyl)sulfanyl]acetic acid

[00964] Step 1 : ethyl [(2-{ [3-(3-chlorophenyl)propyl]amino}ethyl)sulfanyl]acetate

[00965] A mixture of 3-(3-chlorophenyl)propan-l -amine (300 mg, 1.768 mmol) and Example 112- Step 3 (402 mg, 1.768 mmol) in CH ₃ CN (2 mL) was stirred at reflux for 3 hours. The mixture was cooled down and concentrated to give the titled compound. LC-MS (ESI) m/z 316.2 (M+H) ⁺ , RT = 1.634 minutes.

[00966] Step 2: ethyl [(2-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetate

[00967] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (342 mg, 1.741 mmol) in N,N- dimethylformamide (1 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (695 mg, 1.828 mmol, HATU). The resulting solution was stirred at room temperature for 10 minutes. A solution of Example 122-Step 1 (550 mg, 1.741 mmol) in N,N-dimethylformamide (1.0 mL) was added in one portion followed by the addition of diisopropylethylamine (0.608 mL 3.48 mmol). The solution was stirred at room temperature for 1 hour. The mixture was diluted with water (30 mL) and extracted with ethyl acetate (2x20 mL). The combined organic layers were washed with brine (3x20 mL), dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.2 g, 0.405 mmol, 23.25% yield). LC-MS (ESI) m/z 494.2 (M+H) ⁺ , RT = 2.2 minutes.

[00968] Step 3: [(2-{ [3-(3-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetic acid

[00969] To a solution of Example 122-Step 2 (0.2 g, 0.417 mmol) in dioxane (0.5 mL) was added 1 N LiOH (0.5 mL 0.500 mmol) dropwise. The mixture was stirred at 30 °C for 1 hour. The pH of the mixture was adjusted to about 6-7 and then purified by preparative HPLC eluting with

CH ₃ CN/H ₂ 0/CF ₃ C0 ₂ H to give the titled compound (70 mg, 0.150 mmol, 30.0% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.37 - 6.85 (m, 4H), 6.53 (d, J = 35.2 Hz, 2H), 3.80 (d, J = 18.2 Hz, 8H), 3.54 (s, 2H), 3.34 (s, 2H), 2.96 (s, 1H), 2.75 (d, J = 36.0 Hz, 1H), 2.46 (s, 1H), 2.05 (s, 4H), 1.94

- 1.77 (m, 1H); LC-MS (ESI) m/z 466.2 (M+H) ⁺ . Example 123

N-{5-[(ethanesulfonyl)annno]-5-oxopentyl}-3,5-dimethoxy-4-me thyl-N-(3^henylpropyl)benzamide

[00970] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (100 mg, 0.242 mmol, Example 4) and Ι,Γ-carbonyldiimidazole (62.7 mg, 0.387 mmol) in isopropyl acetate (2 mL) was stirred at 40 °C for 10 minutes. Ethanesulfonamide (34.3 mg, 0.314 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (72.9 μΕ, 0.484 mmol) were added, and the reaction mixture was stirred at 40 °C for 18 hours. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 N HC1 and saturated NaCl, dried with MgS0 ₄ and concentrated. The residue was purified by flash chromatography on silica gel (100% ethyl acetate) to give the titled compound (70 mg, 57%). *H NMR (400 MHz, DMSO-<¾) δ ppm 1.17 (t, / = 7.3 Hz, 4H), 1.42 (d, / = 88.4 Hz, 5H), 1.81 (s, 2H), 1.98 (s, 3H), 2.09 - 2.42 (m, 3H), 2.61 (s, 1H), 3.15 (s, 2H), 3.56 (s, 2H), 3.74 (s, 6H), 6.48 (s, 2H), 7.14 (t, / = 45.6 Hz, 5H), 11.51 (s, 1H); MS (DCI) m/z 505 (M+H) ⁺ .

Example 124

3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(propane-2-sulfonyl)amino ]pentyl}-N-(3- phenylpropyl)benzamide

[00971] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (100 mg, 0.242 mmol, Example 4) and Ι,Γ-carbonyldiimidazole (58.8 mg, 0.363 mmol) in isopropyl acetate (2 mL) was stirred at 40 °C for 10 minutes. Propane-2-sulfonamide (32.8 mg, 0.266 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (72.9 μL·, 0.484 mmol) were added, and the reaction mixture was stirred at 40 °C for 18 hours. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 1 N HC1 (10 mL) and saturated NaCl (10 mL), dried with MgS0 ₄ and concentrated. Flash chromatography on silica gel (100% ethyl acetate) gave the titled compound (94 mg, 75%). ¾ NMR (400 MHz, DMSO-<¾) δ ppm 1.21 (d, / = 6.8 Hz, 6H), 1.40 (s, 4H), 1.80 (s, 2H), 1.96 (s, 3H), 2.06 - 2.42 (m, 3H), 2.61 (d, / = 17.3 Hz, 1H), 3.13 (s, 2H), 3.35 (s, 2H), 3.54 (s, 1H), 3.72 (s, 6H), 6.46 (s, 2H), 6.84 - 7.42 (m, 5H), 11.42 (s, 1H); MS (DCI) m/z 519 (M+H) ⁺ .

Example 125

[(2- { [3-(3 ,5 -difluorophenyl)propyl] (3 ,5-dimethoxy-4-methylbenzoyl)amino } ethyl)sulfanyl] acetic acid

[00972] Step 1 : 3-(3,5-difluorophenyl)prop-2-enamide

[00973] To a mixture of l-bromo-3,5-difluorobenzene (5.00 g, 25.9 mmol) and acrylamide (1.842 g, 25.9 mmol) in N,N-dimethylformamide (50 mL) was added triethylamine (13.11 g, 130 mmol), tri- o-tolylphosphine (0.789 g, 2.59 mmol) and tris(dibenzylideneacetone)dipalladium(0) (1.186 g, 1.295 mmol, Pd ₂ (dba) ₃ ). The mixture was stirred at 110 °C overnight. Then the mixture was cooled to room temperature, H ₂ 0 (30 mL) was added to the mixture, and the mixture was extracted with ethyl acetate (50 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give the residue which was purified by chromatography with hexane and acetate (0-80%) to give the titled compound. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.55 (d, J = 15.5 Hz, 1H), 7.13 - 6.94 (m, 2H), 6.82 (td, J = 8.7, 4.4 Hz, 1H), 6.48 (d, J = 15.6 Hz, 1H), 5.82 (brs, 5.82 Hz, 2H).

[00974] Step 2: 3-(3,5-difluorophenyl)propanamide

[00975] To a solution of Example 125-Step 1 (4.18 g, 22.82 mmol) in EtOH (50 mL) was added Pd-C (0.243 g, 2.282 mmol), and the mixture was stirred under a H ₂ atmosphere at room temperature overnight. The catalyst was removed by filtration, and the filtrate was concentrated to give the titled compound (3.99 g, 21.55 mmol, 94% yield). LC-MS (ESI) m/z 186.2 (M+H) ⁺ , RT = 1.42 minutes.

[00976] Step 3: 3-(3,5-difluorophenyl)propan-l-amine

[00977] To a suspension of LiAlH ₄ (1.734 g, 45.7 mmol) in tetrahydrofuran (50 mL) was added a solution of Example 125-Step 2 (4.23 g, 22.84 mmol) in tetrahydrofuran (20 mL). The mixture was stirred at reflux temperature overnight. Then the mixture was cooled to room temperature, and wet Na ₂ S0 ₄ was added to the mixture to quench the reaction. After stirring at room temperature for 15 minutes, the solid was filtered and the filtrate was concentrated to give the residue which was purified by flash chromatography on silica gel eluted with dichloromethane and methanol (0-60%) to give the titled compound (2.30 g, 10.75 mmol, 47.1% yield). *H NMR (400 MHz, CDC1 ₃ ) δ ppm 6.79 - 6.68 (m, 2H), 6.63 (ddd, J = 9.1, 6.7, 2.4 Hz, 1H), 2.79 - 2.72 (m, 2H), 2.66 (dd, J = 8.9, 6.7 Hz, 2H), 2.35 (s, 2H), 1.83 - 1.74 (m, 2H); LC-MS (ESI) m/z 172.2 (M+H) ⁺ , RT = 0.19 minutes.

[00978] Step 4: ethyl [(2-{ [3-(3,5-difluorophenyl)propyl]amino}ethyl)sulfanyl]acetate

[00979] A mixture of Example 125-Step 3 (250 mg, 1.460 mmol) and Example 112-Step 3 (332 mg, 1.460 mmol) in CH ₃ CN (3 mL) was stirred at reflux for 1.5 hours. The solution was cooled down and concentrated to give the titled compound. LC-MS (ESI) m/z 318.2 (M+H) ⁺ , RT = 1.614 minutes.

[00980] Step 5: ethyl [(2-{ [3-(3,5-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetate

[00981] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (289 mg, 1.474 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (617 mg, 1.621 mmol, HATU) in N,N-dimethylformamide (6 mL) was added triethylamine (0.226 mL 1.621 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 125-Step 4 (468 mg, 1.474 mmol) and triethylamine (0.5 mL) in CH ₃ CN (3 mL) was added to the reaction system. The mixture was stirred at room temperature overnight. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-35%) to give the titled compound (364 mg, 0.261 mmol, 17.74% yield). LC-MS (ESI) m/z 496.2 (M+H) ⁺ , RT = 2.150 minutes.

[00982] Step 6: [(2-{ [3-(3,5-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino } ethyl)sulfanyl] acetic acid

[00983] To a solution of Example 125-Step 5 (364 mg, 0.734 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (4.41 mL 4.41 mmol). The mixture was stirred at room temperature for

2 hours. The solution was concentrated under reduced pressure. A solid precipitated that was collected by filtration and washed with water and hexanes. The solid was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (78 mg, 0.167 mmol, 22.71% yield). ^l U NMR (400 MHz, DMSO-<¾) δ ppm 12.58 (s, 1H), 7.02 (s, 1H), 6.92 (s, 1H), 6.77 (s, 1H), 6.53 (s, 1H), 6.47 (s, 1H), 3.84 - 3.66 (m, 6H), 3.58 (s, 1H), 3.40 (s, 1H), 3.32 (s, 2H), 3.17 (s, 1H), 3.03 (s, 1H), 2.82 (s, 1H), 2.75 (s, 1H), 2.66 (s, 1H), 2.42 (s, 1H), 1.97 (s, 3H), 1.88 (s, 1H), 1.80 (s, 1H); LC-MS (ESI) m/z 468.2 (M+H) ⁺ , RT = 1.953 minutes.

Example 126

5-{ [3-(3,5 -difluorophenyl)propyl] (3,5 -dimethoxy-4-methylbenzoyl)amino } pentanoic acid

[00984] Step 1 : methyl 5-{ [3-(3,5-difluorophenyl)propyl]amino}pentanoate

[00985] A mixture of Example 125-Step 3 (250 mg, 1.460 mmol) and methyl 5-bromopentanoate (285 mg, 1.460 mmol) in CH ₃ CN (3 mL) was stirred at reflux for 1.5 hours. The solution was cooled down and concentrated to give the titled compound. LC-MS (ESI) m/z 2 b.2 (M+H) ⁺ , RT = 1.541 minutes.

[00986] Step 2: methyl 5-{ [3-(3,5-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino jpentanoate

[00987] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (289 mg, 1.474 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (617 mg, 1.621 mmol, HATU) in N,N-dimethylformamide (6 mL) was added triethylamine (0.226 mL 1.621 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 126-Step 1 (421 mg, 1.474 mmol) and triethylamine (0.5 mL) in CH ₃ CN (3 mL) was added to the reaction system. The mixture was stirred at room temperature overnight. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine

3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-35%) to give the titled compound (264 mg, 0.296 mmol, 20.09% yield). LC-MS (ESI) m/z 462.2 (M+H) ⁺ , RT = 2.112 minutes.

[00988] Step 3: 5-{ [3-(3,5-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino jpentanoic acid [00989] To a solution of Example 126-Step 2 (264 mg, 0.570 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (3.42 mL 3.42 mmol). The mixture was stirred at room temperature for 2 hours. The solution was concentrated under reduced pressure. The resultant solid was collected by filtration and washed with water and hexanes. This material was further purified by preparative HPLC (0.1% CF ₃ C0 ₂ H-H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (15 mg, 0.033 mmol, 5.86% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.04 (s, 1H), 6.97 (d, J = 39.8 Hz, 2H),

6.76 (s, 1H), 6.49 (s, 1H), 6.44 (s, 1H), 3.74 (dd, J = 11.1, 4.3 Hz, 6H), 3.38 (s, 2H), 3.14 (s, 2H), 2.65 (dd, J = 3.8, 2.0 Hz, 1H), 2.42 (s, 1H), 2.25 (s, 1H), 2.07 (d, J = 9.7 Hz, 1H), 1.97 (s, 3H), 1.88 (s, 1H),

1.77 (s, 1H), 1.53 (s, 3H), 1.29 (s, 1H); LC-MS (ESI) m/z 450.2 (M+H) ⁺ , RT = 1.953 minutes.

Example 127

(2-{ [3-(3,5-dichlorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}ethoxy)acetic acid

[00990] Step 1 : 3-(3,5-dichlorophenyl)propanamide

[00991] A solution of 3-(3,5-dichlorophenyl)propanoic acid (2.0 g, 9.13 mmol) in thionyl chloride (10 mL, 137 mmol) was heated to reflux for 2 hours. The mixture was concentrate, the residue was dissolved in anhydrous tetrahydrofuran (30 mL), and the solution was cooled to 0 °C. Ammonia gas was bubbled in until pH >7, and a solid was formed. Then the mixture was concentrated to give the titled compound (2.096 g, 9.13 mmol, 100% yield). *H NMR (400 MHz, methanol-^) δ ppm 7.26 (t, J = 2.0 Hz, 1H), 7.22 (d, J = 1.9 Hz, 2H), 2.90 (t, J = 7.5 Hz, 2H), 2.50 (t, J = 7.5 Hz, 2H); LC-MS (ESI) m/z 220.0 (M+H) ⁺ , RT = 1.690 minutes.

[00992] Step 2: 3-(3,5-dichlorophenyl)propan-l -amine

[00993] To a solution of Example 127-Step 1 (2.1 g, 9.63 mmol) in tetrahydrofuran (60 mL) was added lithium aluminum hydride (1.0 g, 26.3 mmol) in small portions at 0 °C. Then the reaction mixture was heated to reflux for 2 hours. Then the reaction was quenched with 3.0 g of Na ₂ S0 ₄ . To the mixture was added 5 g Mg ₂ S0 ₄ , and then the solids were removed by filtration. The solution was concentrated to give the titled compound (1.76 g, 6.90 mmol, 71.6% yield). 'H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.19 (t, J = 1.9 Hz, 1H), 7.14 - 7.01 (m, 2H), 2.77 (ddd, J = 9.0, 4.9, 2.0 Hz, 2H), 2.68 - 2.58 (m, 2H), 1.82 (ddd, J = 9.3, 5.2, 2.0 Hz, 2H); LC-MS (ESI) m/z 204.0 (M+H) ⁺ , RT = 1.542 minutes.

[00994] Step 3: N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-3-(3,5-dichlorophenyl) propan-l- amine

[00995] A mixture of (2-bromoethoxy)(teri-butyl)dimethylsilane (0.5 g, 2.090 mmol), Example 127-Step 2 (0.427 g, 2.090 mmol) and potassium carbonate (0.347 g, 2.508 mmol) in acetonitrile (6 mL) was stirred at reflux for 16 hours. The solid was filtered off; and the filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 362.2 (M+H) ⁺ , RT = 1.94 minutes. [00996] Step 4: N-(2-{ [teri-butyl(dimethyl)silyl]oxy }ethyl)-N-[3-(3,5-dichlorophenyl)propyl]-3,5- dimethoxy-4-methylbenzamide

[00997] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (0.224 g, 1.140 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.433 g, 1.140 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.159 mL 1.140 mmol). The resulting solution was stirred at room temperature for 5 minutes. A solution of Example 127-Step 3 (0.551 g, 0.76 mmol) in N,N-dimethylformamide (1.0 mL) was added in one portion. The solution was stirred at room temperature for 3 hours. The mixture was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.38 g, 0.668 mmol, 88% yield). LC-MS (ESI) m/z 540.2 (M+H) ⁺ , RT = 2.54 minutes.

[00998] Step 5: N-[3-(3,5-dichlorophenyl)propyl]-N-(2-hydroxyethyl)-3,5-dime thoxy-4- methylbenzamide

[00999] To a solution of Example 127-Step 4 (0.38 g, 0.703 mmol) in tetrahydrofuran (5 mL) was added tetra-«-butylammonium fluoride (0.221 g, 0.844 mmol). The reaction mixture was stirred at 20 °C for 1 hour. The reaction mixture was concentrated. The residue was dissolved in i-butyl methyl ether (10 mL), washed with water (5 mL) and brine (5 mL), dried over Na ₂ S0 ₄ , filtered and concentrated to give the titled compound. LC-MS (ESI) m/z 426.2 (M+H) ⁺ , RT = 2.04 minutes.

[001000] Step 6: methyl (2-{ [3-(3,5-dichlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetate

[001001] To a solution of Example 127-Step 5 (0.3 g, 0.704 mmol) in tetrahydrofuran (5 mL) was added methyl 2-chloroacetate (0.185 mL 2.111 mmol). Then potassium teri-butoxide (0.237 g, 2.111 mmol) was added in one portion, and the mixture was heated to reflux for 2 hours. The mixture was cooled down, quenched with saturated NH ₄ C1, and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with dichloromethane) eluted with hexanes and ethyl acetate (0-70%) to give the titled compound (0.15 g, 0.271 mmol, 38.5% yield). LC-MS (ESI) m/z 498.2 (M+H) ⁺ , RT = 2.17 minutes.

[001002] Step 7: (2-{ [3-(3,5-dichlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid

[001003] To a solution of Example 127-Step 6 (0.15 g, 0.301 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (1.806 mL 1.806 mmol). The reaction mixture was stirred at 50 °C for 2 hours. The mixture was cooled down and acidified with 1 N HC1 to pH=2-3. The mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a crude product which was purified by preparative HPLC (0.1% ammonium bicarbonate/CH ₃ CN) and lyophilized to give the titled compound (90 mg, 0.182 mmol, 60.5% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.40 - 7.20 (m, 2H), 7.10 (s, 1H), 6.62 - 6.47(m, 2H), 3.90 - 3.85 (m, 1H), 3.80 - 3.70 (m, 7H), 3.65 - 3.55 (m, 2H), 3.45 - 3.23 (m, 4H), 2.66 - 2.56 (m, 1H), 2.45 - 2.35 (m, 1H), 1.97 (s, 3H), 1.95 - 1.73 (m, 2H); LC-MS (ESI) m/z 484.2 (M+H) ⁺ , RT = 2.03 minutes.

Example 128

(2-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}ethoxy)acetic acid

[001004] Step 1 : N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-3-(2,6-difluorophenyl) propan-l -amine

[001005] A mixture of (2-bromoethoxy)(teri-butyl)dimethylsilane (0.5 g, 2.090 mmol), Example 113-Step 2 (0.358 g, 2.090 mmol) and potassium carbonate (0.347 g, 2.508 mmol) in acetonitrile (6 mL) was stirred at reflux for 16 hours. The solid was filtered off and the filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 330.2 (M+H) ⁺ , RT = 1.84 minutes.

[001006] Step 2: N-(2-{ [teri-butyl(dimethyl)silyl]oxy }ethyl)-N-[3-(2,6-difluorophenyl)propyl]-3,5- dimethoxy-4-methylbenzamide

[001007] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (0.247 g, 1.256 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.478 g, 1.256 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.175 mL 1.256 mmol). The resulting solution was stirred at room temperature for 5 minutes. A solution of Example 128-Step 1 (0.36 g, 0.674 mmol, 80% yield) in NN-dimethylformamide (1.0 mL) was added in one portion. The solution was stirred at room temperature for 3 hours. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.36 g, 0.674 mmol, 80% yield). LC-MS (ESI) m/z 508.4 (M+H) ⁺ , RT = 2.47 minutes.

[001008] Step 3: ^-[3-(2,6-difluorophenyl)propyl]-^-(2-hydroxyethyl)-3,5-dime thoxy-4- methylbenzamide

[001009] To a solution of Example 128-Step 2 (0.36 g, 0.709 mmol) in tetrahydrofuran (5 mL) was added tetra-«-butylammonium fluoride (0.222 g, 0.851 mmol). The reaction mixture was stirred at 20 °C for 1 hour, and then the mixture was concentrated. The residue was dissolved in i-butyl methyl ether (10 mL), washed with water (5 mL) and brine (5 mL), dried over Na ₂ S0 ₄ , filtered and concentrated to give the titled compound. LC-MS (ESI) m/z 394.2 (M+H) ⁺ , RT = 1.88 minutes.

[001010] Step 4: methyl (2-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetate [001011] To a solution of Example 128-Step 3 (120 mg, 0.305 mmol) in tetrahydrofuran (3 mL) was added methyl 2-chloroacetate (99 mg, 0.915 mmol). Then potassium teri-butoxide (34.2 mg, 0.305 mmol) was added in one portion. The mixture was heated to reflux for 2 hours, and then the mixture was cooled down and quenched with saturated aqueous ammonium chloride. The mixture was extracted with ethyl acetate 3 times. The combined organic layers were washed with brine once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with dichloromethane) eluted with hexanes and ethyl acetate (0-70%) to give the titled compound (80 mg, 0.155 mmol, 50.7% yield). LC-MS (ESI) m/z 466.2 (M+H) ⁺ , RT = 2.04 minutes.

[001012] Step 5: (2-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid

[001013] To a solution of Example 128-Step 4 (0.08 g, 0.172 mmol) in tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (1.031 mL 1.031 mmol). The reaction mixture was heated to 50 °C for 2 hours. The mixture was cooled down, acidified with 1 N HC1 to pH=2~3, and then extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1 % ammonium bicarbonate/CH ₃ CN) and lyophilized to give the titled compound (15 mg, 0.032 mmol, 18.56% yield). ^l U NMR (400 MHz, DMSO-<¾, T = 20 °C) δ ppm 7.30 - 7.21 (m, 1H), 7.06 - 6.91(m, 2H), 6.61 - 6.44 (m, 2H), 3.95 - 3.85 (m, 1H), 3.80 - 3.68 (m, 7H), 3.65 - 3.45 (m, 4H), 3.25 - 3.15 (m, 2H), 2.67 - 2.60 (m, 1H), 2.44 - 2.36 (m, 1H), 1.97 (s, 3H), 1.88 - 1.68 (m, 2H); LC-MS (ESI) m/z 452.2 (M+H) ⁺ , RT = 1.90 minutes.

Example 129

(2- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(3 -fluorophenyl)propyl] amino } ethoxy)acetic acid

[001014] Step 1 : N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-3-(3-fluorophenyl)prop an-l-amine

[001015] A mixture of 3-(3-fluorophenyl)propan-l-amine (250 mg, 1.632 mmol), (2- bromoethoxy)(teri-butyl)dimethylsilane (390 mg, 1.632 mmol) and K ₂ C0 ₃ (451 mg, 3.26 mmol) in acetonitrile (10 mL) was heated to reflux overnight. Then the mixture was cooled to room temperature, and the solid was filtered and concentrated to give the titled compound. LC-MS (ESI) m/z 312.2 (M+H) ⁺ , RT = 1.83 minutes.

[001016] Step 2: N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-N-[3-(3-fluorophenyl)p ropyl]-3,5- dimethoxy-4-methylbenzamide

[001017] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (320 mg, 1.631 mmol) in N,N- dimethylformamide (5.00 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (620 mg, 1.631 mmol, HATU) and triethylamine (0.682 mL, 4.89 mmol). The mixture was stirred at room temperature for 15 minutes. Then the mixture was added to a solution of Example 129-Step 1 in N,N-dimethylformamide (1.0 mL), and the mixture was stirred at room temperature for 2 hours. The mixture was concentrated, and the residue was diluted with water (20 mL) and extracted with ethyl acetate (30 mL). The organic layer was dried over

Na ₂ S0 ₄ , filtered and concentrated to give the residue which was purified by flash chromatography eluted with hexanes and ethyl acetate (0-30%) to give the titled compound (275 mg, 0.562 mmol,

34.4% yield). LC-MS (ESI) nt/z 490.2 (M+H) ⁺ , RT = 2.42 minutes.

[001018] Step 3: N-[3-(3-fluorophenyl)propyl]-N-(2-hydroxyethyl)-3,5-dimethox y-4- methylbenzamide

[001019] To a solution of Example 129-Step 2 (275 mg, 0.562 mmol) in tetrahydrofuran (5 mL) was added tetra-«-butylammonium fluoride (176 mg, 0.674 mmol) at room temperature. The mixture was stirred at room temperature overnight. The mixture was concentrated, and the residue was combined with ethyl acetate and H ₂ 0 and extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by flash chromatography eluted with hexane and ethyl acetate (0-50%) to give the titled compound (200 mg, 0.533 mmol, 95% yield). LC-MS (ESI) nt/z 376.2 (M+H) ⁺ , RT = 1.88 minutes.

[001020] Step 4: methyl (2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(3- fluorophenyl)propyl] amino } ethoxy) acetate

[001021] To a solution of Example 129-Step 3 (0.2 g, 0.533 mmol) in tetrahydrofuran (5 mL) was added methyl 2-chloroacetate (0.140 mL 1.598 mmol) and potassium teri-butoxide (0.060 g, 0.533 mmol) in one portion. The mixture was heated to reflux for 2 hours. The mixture was cooled down, quenched with saturated aqueous ammonium chloride, and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (eluent: hexanes:ethyl acetate from 100:0 to 50:50) to give the titled compound (0.1 g, 0.212 mmol, 39.9% yield). LC-MS (ESI) nt/z 448.2 (M+H) ⁺ , RT = 2.03 minutes.

[001022] Step 5: (2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(3- fluorophenyl)propyl] amino } ethoxy) acetic acid

[001023] To a solution of Example 129-Step 4 (0.1 g, 0.223 mmol) in tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (1.341 mL 1.341 mmol). It was heated to 50 °C for 2 hours. The mixture was cooled down and acidified with 1 N HCl to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1 % ammonium bicarbonate/CH ₃ CN) and lyophilized to give the titled compound (0.03 g, 0.068 mmol, 30.4% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.34 - 7.09 (m, 4H), 6.63 - 6.50 (m, 2H), 3.76 -3.73 (m, 6H), 3.72- 3.66 (m, 2H), 3.64 - 3.60 (m, 4H), 3.39 - 3.15 (m, 2H), 2.67 - 2.61 (m, 1H), 2.45 - 2.35 (m, 1H), 1.97 (s, 3H), 1.93 - 1.75 (m, 2H); LC-MS (ESI) nt/z 434.2 (M+H) ⁺ , RT = 1.89 minutes. Example 130

(2-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}ethoxy)acetic acid

[001024] Step 1 : N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-3-(2,4-difluorophenyl) propan-l -amine

[001025] A mixture of Example 114-Step 2 (250 mg, 1.460 mmol), (2-bromoethoxy)(teri- butyl)dimethylsilane (349 mg, 1.460 mmol) and K ₂ C0 ₃ (404 mg, 2.92 mmol) in acetonitrile (10 mL) was heated to reflux overnight. Then the mixture was cooled to room temperature, and resultant solid was collected by filtration. The filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 330.2 (M+H) ⁺ , RT = 1.84 minutes.

[001026] Step 2: N-(2-{ [teri-butyl(dimethyl)silyl]oxy }ethyl)-N-[3-(3,4-difluorophenyl)propyl]-3,5- dimethoxy-4-methylbenzamide

[001027] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (286 mg, 1.460 mmol) in N,N- dimethylformamide (5.00 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (555 mg, 1.460 mmol, HATU) and triethylamine (0.610 mL, 4.38 mmol). The mixture was stirred at room temperature for 15 minutes. Then the mixture was combined with a solution of Example 130-Step 1 in N,N-dimethylformamide (1.0 mL), and the mixture was stirred at room temperature for 2 hours. The mixture was concentrated, and the residue was diluted with water (20 mL) and extracted with ethyl acetate (30 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give the residue which was purified by flash

chromatography with hexanes and ethyl acetate (0-30%) to give the titled compound (213 mg, 0.420 mmol, 28.7% yield). LC-MS (ESI) m/z 508.2 (M+H) ⁺ , RT = 2.43 minutes.

[001028] Step 3: N-[3-(3,4-difluorophenyl)propyl]-N-(2-hydroxyethyl)-3,5-dime thoxy-4- methylbenzamide

[001029] To a solution of Example 130-Step 2 (213 mg, 0.420 mmol) in tetrahydrofuran (5 mL) was added tetra-«-butylammonium fluoride (132 mg, 0.503 mmol) at room temperature. The mixture was stirred at room temperature overnight. The mixture was concentrated, and the residue was diluted with ethyl acetate and H ₂ 0. The mixture was extracted with ethyl acetate (20 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by flash chromatography eluted with hexane and ethyl acetate (0-50%) to give the titled compound (100 mg, 0.254 mmol, 60.6% yield). LC-MS (ESI) m/z 394.2 (M+H) ⁺ , RT = 1.94 minutes.

[001030] Step 4: methyl (2-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetate

[001031] To a solution of Example 130-Step 3 (0.12 g, 0.305 mmol) in tetrahydrofuran (5 mL) was added methyl 2-chloroacetate (0.080 mL 0.915 mmol) and potassium teri-butoxide (0.034 g, 0.305 mmol) in one portion. The mixture was heated to reflux for 2 hours. The mixture was cooled down and quenched with saturated aqueous ammonium chloride, and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (eluent: hexanes:ethyl acetate from 100:0 to 50:50) to give the titled compound (0.1 g, 0.204 mmol, 66.9% yield) as an oil. LC-MS (ESI) m/z 466.2 (M+H) ⁺ , RT = 2.04 minutes.

[001032] Step 5: (2-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid

[001033] To a solution of Example 130-Step 4 (0.08 g, 0.172 mmol) in tetrahydrofuran (2 mL) was added 1 N LiOH (1.031 mL 1.031 mmol). It was heated to 50 °C for 2 hours. The mixture was cooled down and acidified with 1 N HC1 to pH=2~3 and then extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1% ammonium bicarbonate/CH ₃ CN) and lyophilized to give the titled compound (0.03 g, 0.065 mmol, 37.9% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.45- 6.80 (m, 3H), 6.65 - 6.40 (m, 2H), 4.0 - 3.85 (m, 2H), 3.80 -3.68 (m, 6H), 3.65- 3.50 (m, 4H), 3.35- 3.10 (m, 2H), 2.65 - 2.55 (m, 1H), 2.43 - 2.30 (m, 1H), 1.97 (s, 3H), 1.90 - 1.70 (m, 2H); LC-MS (ESI) m/z 452.2 (M+H) ⁺ , RT = 1.90 minutes.

Example 131

(2-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl)ami no}ethoxy)acetic acid

[001034] Step 1 : N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-3-(2-chlorophenyl)prop an-l-amine

[001035] A mixture of (2-bromoethoxy)(teri-butyl)dimethylsilane (0.5 g, 2.090 mmol), 3-(2- chlorophenyl)propan-l -amine (0.355 g, 2.090 mmol) and potassium carbonate (0.347 g, 2.508 mmol) in acetonitrile (6 mL) was stirred at reflux for 16 hours. The solid was filtered off and the filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 328.2 (M+H) ⁺ , RT = 1.87 minutes.

[001036] Step 2: N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-N-[3-(2-chlorophenyl)p ropyl]-3,5- dimethoxy-4-methylbenzamide

[001037] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (0.246 g, 1.253 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.476 g, 1.253 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.175 mL 1.253 mmol). The resulting solution was stirred at room temperature for 5 minutes. A solution of Example 131-Step 1 (0.685 g, 0.835 mmol) in N,N-dimethylformamide (1.0 mL) was added in one portion. The solution was stirred at room temperature for 3 hours. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.2 g, 0.375 mmol, 44.9% yield). LC-MS (ESI) m/z 506.2 (M+H) ⁺ , RT = 2.49 minutes. [001038] Step 3: N-[3-(2-chlorophenyl)propyl]-N-(2-hydroxyethyl)-3,5-dimethox y-4- methylbenzamide

[001039] To a solution of Example 131-Step 2 (0.2 g, 0.395 mmol) in tetrahydrofuran (5 mL) was added tetra-«-butylammonium fluoride (0.124 g, 0.474 mmol). The reaction mixture was stirred at 20 °C for 1 hour and then concentrated. The residue was dissolved in t- butyl methyl ether (10 mL) and washed with water (5 mL) and brine (5 mL), dried over Na ₂ S0 ₄ , filtered and concentrated to give the titled compound. LC-MS (ESI) m/z 392.2 (M+H) ⁺ , RT = 1.94 minutes.

[001040] Step 4: methyl (2-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetate

[001041] To a solution of Example 131-Step 3 (0.2 g, 0.510 mmol) in tetrahydrofuran (5 mL) was added methyl 2-chloroacetate (0.134 mL 1.531 mmol) and potassium teri-butoxide (0.057 g, 0.510 mmol) in one portion. The mixture was heated to reflux for 2 hours. The mixture was cooled down, quenched with saturated aqueous ammonium chloride, and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (eluent: hexanes:ethyl acetate from 100:0 to 50:50) to give the titled compound (0.12 g, 0.233 mmol, 45.6% yield). LC-MS (ESI) m/z 464.2 (M+H) ⁺ , RT = 2.08 minutes.

[001042] Step 5: (2-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino}ethoxy)acetic acid

[001043] To a solution of Example 131-Step 4 (0.12 g, 0.259 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (1.552 mL 1.552 mmol). The reaction mixture was heated to 50 °C for 2 hours. The mixture was cooled down and acidified with 1 N HC1 to pH=2~3. The mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated. The residue was purified by preparative HPLC (0.1 % ammonium bicarbonate/CH ₃ CN) and lyophilized to give the titled compound (40 mg, 0.087 mmol, 33.7% yield). ^l U NMR (400 MHz, DMSO-<¾, T = 20 °C) δ ppm 7.45 - 7.35 (m, 1H), 7.32 - 7.10 (m, 3H), 6.61 - 6.48(m, 2H), 3.98 - 3.89 (m, 2H), 3.75 - 3.74 (m, 6H), 3.65 - 3.49 (m, 2H), 3.39 - 3.20 (m, 4H), 2.75 - 2.66 (m, 1H), 2.50 - 2.48 (m, 1H), 1.97 (s, 3H), 1.90 - 1.72 (m, 2H); LC-MS (ESI) m/z 450.2 (M+H) ⁺ , RT = 1.94 minutes.

Example 132

[(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2-yl)p ropyl]amino}ethyl)sulfanyl]acetic acid

[001044] Step l : 2-(3-chloropropyl)-5-methylfuran

[001045] To a cooled stirred solution of 2-methylfuran (3.0 g, 36.5 mmol) in tetrahydrofuran (60 mL) was added butyllithium (27.4 mL, 43.8 mmol) dropwise at -78 °C. Then the mixture was stirred at 0 °C for 1.5 hour. l-Chloro-3-iodopropane (9.71 g, 47.5 mmol) was added dropwise, and the resulting solution was stirred for 16 hours at room temperature. Then the solution was concentrated to give the titled compound. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 5.90 (d, J = 3.0 Hz, 1H), 5.85 (d, J = 3.0 Hz, 1H), 3.56 (t, J = 6.5 Hz, 2H), 2.75 (t, J = 7.2 Hz, 2H), 2.25 (s, 3H), 2.09 (p, J = 6.9 Hz, 2H).

[001046] Step 2: 2-[3-(5-methylfuran-2-yl)propyl]-lH-isoindole-l,3(2H)-dione

[001047] To a stirred solution of Example 132-Step 1 (5.8 g, 36.6 mmol) in CH ₃ CN (80 mL) was added isoindoline-l,3-dione (8.07 g, 54.8 mmol), sodium iodide (5.48 g, 36.6 mmol) and potassium carbonate (15.16 g, 110 mmol), and then the mixture was stirred at 85 °C over a weekend. The mixture was concentrated, and the residue was partitioned between water (100 mL) and ethyl acetate (100 mL). The organic layer was separated and concentrated. The residue was purified by flash column (0-45% ethyl acetate in n-hexane) to give the titled compound (4.0 g, 13.67 mmol, 37.4% yield). *H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.92 - 7.78 (m, 2H), 7.78 - 7.64 (m, 2H), 5.90 (d, J = 3.0 Hz, 1H), 5.78 (dq, J = 3.1, 1.1 Hz, 1H), 3.84 - 3.64 (m, 2H), 2.65 (t, J = 7.5 Hz, 2H), 2.19 (d, J = 0.9 Hz, 3H), 2.07 - 1.93 (m, 2H); LC-MS (ESI) m/z 270.2 (M+H) ⁺ , RT = 1.994 minutes.

[001048] Step 3: 3-(5-methylfuran-2-yl)propan-l -amine

[001049] To a stirred solution of Example 132-Step 2 (4.0 g, 14.85 mmol) in CH ₃ OH (40 mL) was added hydrazine hydrate (1.957 g, 37.1 mmol) dropwise. Then the mixture was stirred at 80 °C for 3 hours. The solution was cooled, and the solid was removed by filtration. The filtrate was concentrated, and the residue was dissolved in ethyl ether (100 mL). The produced solid was removed again by filtration. The filtrate was concentrated, and the residue was dried under vacuum to give the titled compound (1.58 g, 10.22 mmol, 68.8% yield). *H NMR (400 MHz, CDC1 ₃ ) δ ppm 5.92 - 5.76 (m, 2H), 2.75 (td, J = 7.0, 1.1 Hz, 2H), 2.62 (t, J = 7.5 Hz, 2H), 2.24 (d, J = 0.9 Hz, 3H), 1.85 - 1.72 (m, 2H), 1.70 (s, 2H); LC-MS (ESI) m/z 140.2 (M+H) ⁺ , RT = 0.922 minutes.

[001050] Step 4: ethyl [(2-bromoethyl)sulfanyl]acetate

[001051] A mixture of ethyl 2-mercaptoacetate (10.0 g, 83 mmol), 1 ,2-dibromoethane (46.9 g, 250 mmol) and K ₂ C0 (34.5 g, 250 mmol) in acetonitrile (150 mL) was heated to reflux for 2 hours. Then the mixture was cooled to room temperature, the solid was removed by filtration, and the filtrate was concentrated to give a residue which was purified by chromatography on silica gel eluted with hexane and ethyl acetate (0-10%) to give the titled compound (14.0 g, 61.6 mmol, 74.1% yield).

[001052] Step 5: ethyl [(2-{ [3-(5-methylfuran-2-yl)propyl]amino}ethyl)sulfanyl]acetate

[001053] A mixture of Example 132-Step 3 (300 mg, 2.155 mmol), Example 132-Step 4 (489 mg, 2.155 mmol) and potassium carbonate (447 mg, 3.23 mmol) in CH ₃ CN (7 mL) was stirred at reflux for 2 hours. The solution was cooled down, filtered and concentrated to give the titled compound. LC-MS (ESI) m/z 286.2 (M+H) ⁺ , RT = 1.523 minutes.

[001054] Step 6: ethyl [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } ethyl)sulfanyl] acetate [001055] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (423 mg, 2.155 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (901 mg, 2.371 mmol, HATU) in N,N-dimethylformamide (8 mL) was added triethylamine (0.330 mL 2.371 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 132-Step 5 (615 mg, 2.155 mmol) in CH ₃ CN was added to the reaction system. The mixture was stirred at room temperature overnight. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-35%) to give the titled compound (719 mg, 0.775 mmol, 36.0% yield). LC-MS (ESI) nt/z 464.2 (M+H) ⁺ , RT = 2.109 minutes.

[001056] Step 7: [(2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } ethyl)sulfanyl] acetic acid

[001057] To a solution of Example 132-Step 6 (719 mg, 1.551 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (9.31 mL 9.31 mmol). The mixture was stirred at room temperature for 1 hour. The solution was concentrated under reduced pressure. A solid precipitated from the aqueous mixture. The solid was collected by filtration and washed with water and hexanes to give the titled compound. A portion was purified by preparative HPLC (0.1 % CF ₃ CO ₂ H-H ₂ O/CH ₃ CN) and lyophilized to give the titled compound (35 mg, 0.080 mmol, 5.18% yield). H NMR (400 MHz, DMSO-i¾) δ ppm 12.59 (s, 1H), 6.53 (s, 2H), 5.96 (d, J = 30.7 Hz, 1H), 5.78 (d, J = 21.6 Hz, 1H), 3.75 (s, 6H), 3.57 (s, 1H), 3.40 (s, 2H), 3.33 (s, 1H), 3.21 (s, 1H), 3.03 (s, 1H), 2.82 (s, 1H), 2.74 (s, 1H), 2.67 - 2.51 (m, 1H), 2.37 (s, 1H), 2.19 (s, 1H), 2.09 (s, 2H), 1.98 (s, 3H), 1.83 (d, J = 18.3 Hz, 2H); LC-MS (ESI) nt/z 436.2 (M+H) ⁺ , RT = 1.849 minutes.

Example 133

5- { (3 , 5 -dimethoxybenzoyl) [3 -(5 -methylfur an-2-yl)propyl] amino } pentanoic acid

[001058] Step 1 : methyl 5-{ [3-(5-methylfuran-2-yl)propyl]amino}pentanoate

[001059] A solution of Example 132-Step 3 (500 mg, 3.59 mmol) and methyl 5-bromopentanoate (701 mg, 3.59 mmol) in CH ₃ CN (10 mL) was stirred at reflux. The mixture was cooled down and concentrated to give the titled compound. LC-MS (ESI) m/z 254.2 (M+H) ⁺ , RT = 1.517 minutes.

[001060] Step 2: methyl 5-{(3,5-dimethoxybenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } pentanoate

[001061] To a solution of 3,5-dimethoxybenzoic acid (327 mg, 1.795 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (751 mg, 1.975 mmol, HATU) in N,N-dimethylformamide (8 mL) was added triethylamine (0.275 mL 1.975 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 133-Step 1 (455 mg, 1.795 mmol) and triethylamine (2 mL) in CH ₃ CN was added to the reaction system. The mixture was stirred at room temperature overnight. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-35%) to give the titled compound (315 mg, 0.626 mmol, 34.9% yield). LC-MS (ESI) m/z 418.2 (M+H) ⁺ , RT = 1.991 minutes.

[001062] Step 3: 5-{(3,5-dimethoxybenzoyl)[3-(5-methylfuran-2-yl)propyl]amino }pentanoic acid

[001063] To a solution of Example 133-Step 2 (315 mg, 0.754 mmol) in tetrahydrofuran (6 mL) was added 1 N lithium hydroxide (4.53 mL 4.53 mmol). The mixture was stirred at room temperature for 1 hour. The solution was concentrated under reduced pressure. The aqueous mixture was washed with i-butyl methyl ether once. Then the aqueous mixture was acidified with 1 N HC1 to pH=2~3 and extracted with ethyl acetate once. The organic layer was concentrated. The residue was purified by preparative HPLC (0.1% CF ₃ CO ₂ H-H ₂ O/CH ₃ CN) and lyophilized to give the titled compound (25 mg, 0.062 mmol, 8.21% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.03 (s, 1H), 6.50 (d, J = 2.8 Hz, 1H), 6.39 (d, J = 3.1 Hz, 2H), 6.02 - 5.89 (m, 1H), 5.78 (d, J = 28.8 Hz, 1H), 3.73 (s, 6H), 3.37 (d, J = 7.4 Hz, 2H), 3.13 (s, 2H), 2.56 (d, J = 7.8 Hz, 1H), 2.35 (t, J = 7.1 Hz, 1H), 2.24 (d, J = 6.3 Hz, 1H), 2.16 (d, J = 31.3 Hz, 3H), 2.07 (t, J = 8.0 Hz, 1H), 1.84 (t, J = 7.3 Hz, 1H), 1.79 - 1.69 (m, 1H), 1.53 (s, 3H), 1.33 - 1.22 (m, 1H); LC-MS (ESI) m/z 404.2 (M+H) ⁺ , RT = 1.853 minutes.

Example 134

5-{(3,5-dimethoxybenzoyl)[3-(2-fluorophenyl)propyl]amino}pen tanoic acid

[001064] Step 1 : methyl 5- { [3 -(2-fluorophenyl)propyl] amino jpentanoate

[001065] In a 10 mL sealed tube was added 3-(2-fluorophenyl)propan-l -amine (0.5 g, 3.26 mmol), methyl 5-bromopentanoate (0.637 g, 3.26 mmol), K ₂ C0 ₃ (0.541 g, 3.92 mmol) and acetonitrile (5 mL). The reaction mixture was stirred at reflux for 1 hour. The mixture was cooled to room temperature and filtered to remove the solids. The filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 268.2 (M+H) ⁺ , RT = 1.51 minutes.

[001066] Step 2: methyl 5-{(3,5-dimethoxybenzoyl)[3-(2-fluorophenyl)propyl]amino}pen tanoate

[001067] To a solution of 3,5-dimethoxybenzoic acid (0.267 g, 1.464 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.594 g, 1.562 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.218 mL 1.562 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 134-Step 1 (0.87 g, 0.976 mmol) in CH ₃ CN (5 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with saturated NaHC0 ₃ solution (1x10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was added to a silica gel column and was eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.26 g, 0.542 mmol, 55.5% yield). LC-MS (ESI) m/z 432.2 (M+H) ⁺ , RT = 2.0 minutes.

[001068] Step 3: 5-{(3,5-dimethoxybenzoyl)[3-(2-fluorophenyl)propyl]amino}pen tanoic acid

[001069] To a solution of Example 134-Step 2 (0.26 g, 0.603 mmol) in tetrahydrofuran (6 mL) was added 1 N LiOH (3.62 mL 3.62 mmol). The reaction mixture was heated to 50 °C for 2 hours. The mixture was concentrated, and the resultant mixture was extracted with i-butyl methyl ether (5 mL). The water layer was separated and acidified with 1 N HC1 to pH=2~3. This was then extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in water/CH ₃ CN) and lyophilized to give the titled compound (0.036 g, 0.085 mmol, 14.03% yield). *H NMR (400 MHz, DMSO-<¾, T = 20 °C) δ ppm 7.40 - 7.0 (m, 4H), 6.51- 6.46 (m, 1H), 6.39- 6.35 (m, 2H), 3.73 - 3.72 (m, 6H), 3.45 - 3.33 (m, 2H), 3.17 - 3.07 (m, 2H), 2.67 - 2.60 (m, 1H), 2.43 - 2.35 (m, 1H), 2.27 - 2.20 (m, 1H), 2.10 - 2.02 (m, 1H), 1.90 - 1.70 (m, 2H), 1.60- 1.40 (m, 3H), 1.32 - 1.20 (m, 1H); LC-MS (ESI) m/z 418.2 (M+H) ⁺ , RT = 1.86 minutes.

Example 135

5-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pentan oic acid

[001070] Step 1 : methyl 5-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pentan oate

[001071] To a solution of 3,5-dimethoxybenzoic acid (0.274 g, 1.506 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.611 g, 1.607 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.224 mL 1.607 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of methyl 5-{ [3-(2-chlorophenyl)propyl]amino}pentanoate (Prepared using the procedure described for Example 134-Step 1 substituting 3-(2-chlorophenyl)propan-l-amine for 3-(2-fluorophenyl)propan- 1 -amine.) (0.95 g, 1.004 mmol) in CH ₃ CN (5 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with saturated NaHC0 ₃ solution (1x10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue. The residue was applied to a silica gel column and eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.15 g, 0.301 mmol, 30.0% yield). LC-MS (ESI) m/z 448.2 (M+H) ⁺ , RT = 2.05 minutes.

[001072] Step 2: 5-{ [3-(2-chlorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pentan oic acid

[001073] To a solution of Example 135-Step 1 (0.15 g, 0.335 mmol) in tetrahydrofuran (4 mL) was added 1 N LiOH (2.009 mL 2.009 mmol). The reaction mixture was heated to 50 °C for 2 hours. The mixture was concentrated, and the resultant aqueous mixture was extracted with i-butyl methyl ether (5 mL). The water layer was separated and acidified with 1 N HC1 to pH=2~3. The acidic aqueous mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated. The residue was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in water/CH ₃ CN) and lyophilized to give the titled compound (0.03 g, 0.068 mmol, 20.23% yield). *H NMR (400 MHz, DMSO-<¾, T = 20 °C) δ ppm 12.02 (brs, 1H), 7.44 - 7.10 (m, 4H), 6.54 - 6.44 (m, 1H), 6.44 - 6.30 (m, 2H), 3.72 (s, 6H), 3.48 - 3.32 (m, 2H), 3.22 - 3.04 (m, 2H), 2.78 - 2.66 (m, 1H), 2.45 - 2.40 (m, 1H), 2.30 - 2.20 (m, 1H), 2.12 - 2.00 (m, 1H), 1.90 - 1.68 (m, 2H), 1.62 - 1.40 (m, 3H), 1.34 - 1.20 (m, 1H); LC-MS (ESI) m/z 434.2 (M+H) ⁺ , RT = 1.88 minutes.

Example 136

5- { [3 -(3 ,5 -difluorophenyl)propyl] (3 ,5-dimethoxybenzoyl)amino jpentanoic acid

[001074] Step l : methyl 5-{ [3-(3,5-difluorophenyl)propyl](3,5- dimethoxybenzoyl)amino}pentanoate

[001075] To a solution of 3,5-dimethoxybenzoic acid (0.250 g, 1.372 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.556 g, 1.464 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.204 mL 1.464 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 126-Step 1 (0.87 g, 0.915 mmol) in CH ₃ CN (5 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic fractions were washed with saturated NaHC0 ₃ solution (1x10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue. The residue was added to a silica gel column and was eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.12 g, 0.240 mmol, 26.3% yield). LC-MS (ESI) m/z 450.2 (M+H) ⁺ , RT = 1.98 minutes.

[001076] Step 2: 5-{ [3-(3,5-difluorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pe ntanoic acid

[001077] To a solution of Example 136-Step 1 (0.12 g, 0.267 mmol) in tetrahydrofuran (3 mL) was added 1 N LiOH (1.602 mL 1.602 mmol). The reaction mixture was heated to 50 °C for 2 hours. The mixture was concentrated, and the remaining aqueous mixture was extracted with i-butyl methyl ether (5 mL). The water layer was separated and acidified with 1 N HC1 to pH=2~3. The acidic aqueous fraction was extracted with ethyl acetate twice. The combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in water/CH ₃ CN) and lyophilized to give the titled compound (0.025 g, 0.056 mmol, 21.07% yield). H NMR (400 MHz, DMSO-d ₆ , T = 20 °C) δ ppm 12.02 (brs, 1H), 7.10 - 6.90 (m, 2H), 6.82- 6.70 (m, 1H), 6.55- 6.30 (m, 3H), 3.73 - 3.71 (m, 6H), 3.45 - 3.30 (m, 2H), 3.20 - 3.00 (m, 2H), 2.70 - 2.60 (m, 1H), 2.45 - 2.35 (m, 1H), 2.30 - 2.15 (m, 1H), 2.10 - 2.00 (m, 1H), 1.92 - 1.70 (m, 2H), 1.60 - 1.40 (m, 3H), 1.35 - 1.20 (m, 1H); LC-MS (ESI) nt/z 436.2 (M+H) ⁺ , RT = 1.87 minutes.

Example 137

5-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pe ntanoic acid

[001078] Step 1 : methyl 5-{ [3-(2,6-difluorophenyl)propyl]amino}pentanoate

[001079] In a 10 mL sealed tube was added Example 113-Step 2 (0.6 g, 3.50 mmol), methyl 5- bromopentanoate (0.684 g, 3.50 mmol), K ₂ C0 ₃ (0.581 g, 4.21 mmol) and acetonitrile (5 mL). The reaction mixture was stirred at reflux for 1 hour. The mixture was cooled to room temperature and filtered to remove potassium carbonate. The filtrate was concentrated to give the titled compound. LC-MS (ESI) nt/z 286.2 (M+H) ⁺ , RT = 0.21 minutes.

[001080] Step 2: methyl 5-{ [3-(2,6-difluorophenyl)propyl](3,5- dimethoxybenzoyl)amino}pentanoate

[001081] To a solution of 3,5-dimethoxybenzoic acid (0.259 g, 1.419 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.576 g, 1.514 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.211 mL 1.514 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 137-Step 1 (0.9 g, 0.946 mmol) in CH ₃ CN (5 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic fractions were washed with saturated NaHC0 ₃ solution (1x10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue. The residue was added to a silica gel column and was eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.2 g, 0.445 mmol, 47.0% yield). LC-MS (ESI) nt/z 450.2 (M+H) ⁺ , RT = 2.02 minutes.

[001082] Step 3: 5-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxybenzoyl)amino}pe ntanoic acid

[001083] To a solution of Example 137-Step 2 (0.2 g, 0.445 mmol) in tetrahydrofuran (5 mL) was added 1 N LiOH (2.67 mL 2.67 mmol). The reaction mixture was heated to 50 °C for 2 hours. The reaction mixture was concentrated, and the remaining aqueous mixture was extracted with i-butyl methyl ether (5 mL). The water layer was separated and acidified with 1 N HC1 to pH=2~3. The acidic aqueous fraction was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue which was precipitated from CH ₃ CN (2 mL) to give the titled compound (0.05 g, 0.109 mmol, 24.52% yield). *H NMR (400 MHz, DMSO-<¾, T = 20 °C) δ ppm 12.0 (s, 1H), 7.32 - 7.20 (m, 1H), 7.10 - 6.90 (m, 2H), 6.55- 6.25 (m, 3H), 3.73 - 3.70 (m, 6H), 3.45 - 3.34 (m, 2H), 3.20 - 3.05 (m, 2H), 2.70 - 2.60 (m, 1H), 2.5 - 2.38 (m, 1H), 2.27 - 2.20 (m, 1H), 2.10 - 2.00 (m, 1H), 1.87 - 1.65 (m, 2H), 1.60 - 1.40 (m, 3H), 1.35 - 1.20 (m, 1H); LC-MS (ESI) nt/z 436.2 (M+H) ⁺ , RT = 1.87 minutes. Example 138

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2-yl)pro pyl]amino}pentanoic acid

[001084] Step 1 : methyl 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } pentanoate

[001085] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (352 mg, 1.795 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (751 mg, 1.975 mmol, HATU) in N,N-dimethylformamide (8 mL) was added triethylamine (0.275 mL 1.975 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 133-Step 1 (455 mg, 1.795 mmol) and triethylamine (2 mL) in CH ₃ CN was added to the reaction system. The mixture was stirred at room temperature overnight. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-35%) to give the titled compound (313 mg, 0.508 mmol, 28.3% yield). LC-MS (ESI) m/z 432.2 (M+H) ⁺ , RT = 2.055 minutes.

[001086] Step 2: 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2- yl)propyl] amino jpentanoic acid

[001087] To a solution of Example 138-Step 1 (313 mg, 0.725 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (4.35 mL 4.35 mmol). The mixture was stirred at room temperature for 1 hour and then concentrated. The remaining aqueous mixture was washed with i-butyl methyl ether once. Then the aqueous fraction was acidified with 1 N HC1 to pH=2-3 and extracted with ethyl acetate once. The organic layer was concentrated. The residue was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H in water/CH ₃ CN) and lyophilized twice to give the titled compound (25 mg, 0.060 mmol, 8.26% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.02 (s, IH), 6.50 (s, 2H), 5.96 (d, J = 29.2 Hz, IH), 5.77 (d, J = 23.1 Hz, IH), 3.75 (s, 6H), 3.37 (s, 2H), 3.16 (s, 2H), 2.58 (s, IH), 2.37 (s, IH), 2.25 (s, IH), 2.19 (s, 2H), 2.09 (s, 2H), 1.98 (s, 3H), 1.86 (s, IH), 1.77 (s, IH), 1.53 (s, 3H), 1.29 (s, IH); LC-MS (ESI) m/z 418.2 (M+H) ⁺ , RT = 1.925 minutes.

Example 139

(2- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(4-fluorophenyl)propyl] amino } ethoxy)acetic acid

[001088] Step 1 : N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-3-(4-fluorophenyl)prop an-l-amine

[001089] In a 10 mL sealed tube was added (2-bromoethoxy)(teri-butyl)dimethylsilane (0.468 g, 1.958 mmol), 3-(4-fluorophenyl)propan-l-amine (0.3 g, 1.958 mmol), potassium carbonate (0.325 g, 2.350 mmol) and acetonitrile (6 mL). The reaction mixture was stirred at reflux for 16 hours. The mixture was cooled to room temperature and filtered to remove potassium carbonate. The filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 312.2 (M+H) ⁺ , RT = 1.83 minutes.

[001090] Step 2: N-(2-{ [teri-butyl(dimethyl)silyl]oxy}ethyl)-N-[3-(4-fluorophenyl)p ropyl]-3,5- dimethoxy-4-methylbenzamide

[001091] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (0.346 g, 1.762 mrnol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.670 g, 1.762 mrnol, HATU) in N,N-dimethylformamide (10 mL) was added triethylamine (0.246 mL 1.762 mrnol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 139-Step 1 (0.61 g, 1.175 mrnol) in CH ₃ CN (10 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic fractions were washed with saturated NaHC0 ₃ solution (1x10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue. The residue was added to a silica gel column and was eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.44 g, 0.764 mrnol, 65.0% yield). LC-MS (ESI) m/z 490.4 (M+H) ⁺ , RT = 2.38 minutes.

[001092] Step 3: N-[3-(4-fluorophenyl)propyl]-N-(2-hydroxyethyl)-3,5-dimethox y-4- methylbenzamide

[001093] To a solution of Example 139-Step 2 (0.44 g, 0.899 mrnol) in tetrahydrofuran (10 mL) was added tetra-«-butylammonium fluoride (0.235 g, 0.899 mrnol). The reaction mixture was stirred at 20 °C for 1 hour. The reaction mixture was concentrated. The residue was dissolved in i-butyl methyl ether (10 mL), washed with water (5 mL) and brine (5 mL), dried over Na ₂ S0 ₄ , filtered and concentrated to give the titled compound. LC-MS (ESI) m/z 376.2 (M+H) ⁺ , RT = 1.88 minutes.

[001094] Step 4: methyl (2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4- fluorophenyl)propyl] amino } ethoxy) acetate

[001095] To a solution of Example 139-Step 3 (0.338 g, 0.899 mrnol) in tetrahydrofuran (5 mL) was added methyl 2-chloroacetate (0.293 g, 2.70 mrnol) and potassium teri-butoxide (0.303 g, 2.70 mrnol) in one portion. The mixture was heated to reflux for 2 hours. The mixture was cooled down, quenched with saturated aqueous ammonium chloride, and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (eluent: hexanes:ethyl acetate from 100:0 to 50:50) to give the titled compound (0.2 g, 0.402 mrnol, 44.7% yield). LC-MS (ESI) m/z 448.2 (M+H) ⁺ , RT = 2.02 minutes.

[001096] Step 5: (2-{(3,5-dimethoxy-4-methylbenzoyl)[3-(4- fluorophenyl)propyl] amino } ethoxy) acetic acid

[001097] To a solution of Example 139-Step 4 (0.2 g, 0.447 mrnol) in tetrahydrofuran (6 mL) was added 1 N LiOH (2.68 mL 2.68 mrnol). The reaction mixture was heated to 50 °C for 2 hours. The reaction mixture was concentrated, and the remaining aqueous mixture was extracted with i-butyl methyl ether (5 mL). The water layer was separated and acidified with 1 N HCl to pH=2~3. The acidic aqueous fraction was extracted with ethyl acetate twice. The combined organic layers were concentrated to give a crude product, which was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in water/CH ₃ CN) and lyophilized to give the titled compound (0.052 g, 0.118 mmol, 26.3% yield). 'H NMR (400 MHz, DMSO-d ₆ ) δ ppm 7.35 - 7.22 (m, 1H), 7.15 - 6.90 (m, 3H), 6.65 - 6.45 (m, 2H), 4.07 - 3.90 (m, 2H), 3.79 -3.69 (m, 6H), 3.68 - 3.49 (m, 3H), 3.48 - 3.31 (m, 2H), 3.21 - 3.14 (m, 1H), 2.68 - 2.56 (m, 1H), 2.45 - 2.31 (m, 1H), 1.98 (s, 3H), 1.91 - 1.71 (m, 2H); LC-MS (ESI) m/z 434.2 (M+H) ⁺ , RT = 1.89 minutes.

Example 140

N-{5-[(4-fluorobenzene-l-sulfonyl)amino]-5-oxopentyl}-3,5-di methoxy-4-methyl-N-(3- phenylpropyl)benzamide

[001098] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (100 mg, 0.242 mmol, Example 4) and Ι,Γ-carbonyldiimidazole (62.7 mg, 0.387 mmol) in isopropyl acetate (2 mL) was stirred at 40 °C for 10 minutes. 4-Fluorobenzenesulfonamide (55.1 mg, 0.314 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (72.9 μL·, 0.484 mmol) were added, and the reaction mixture was stirred at 40 °C for 18 hours. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL each of 1 N HCl and saturated NaCl, dried with MgS0 ₄ and concentrated. Flash chromatography on silica gel (100% ethyl acetate) gave the titled compound (91 mg, 66%). ¾ NMR (400 MHz, DMSO-<¾) δ ppm 1.30 (d, / = 80.5 Hz, 5H), 1.77 (d, / = 21.1 Hz, 2H), 1.96 (s, 3H), 2.02 - 2.43 (m, 3H), 2.57 (s, 1H), 3.07 (s, 2H), 3.71 (s, 6H), 6.43 (s, 2H), 6.84 - 7.36 (m, 5H), 7.36 - 7.49 (m, 2H), 7.94 (dd, / = 8.7, 5.1 Hz, 2H), 12.07 (s, 1H); MS (DCI) m/z 571 (M+H) ⁺ .

Example 141

3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(pyridine-2-sulfonyl)amin o]pentyl}-N-(3- phenylpropyl)benzamide

[001099] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (100 mg, 0.242 mmol, Example 4) and Ι,Γ-carbonyldiimidazole (62.7 mg, 0.387 mmol) in isopropyl acetate (2 mL) was stirred at 40 °C for 10 minutes. Pyridine-2-sulfonamide (49.7 mg, 0.314 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (72.9 μL·, 0.484 mmol) were added, and the reaction mixture was stirred at 40 °C for 18 hours. The reaction mixture was diluted with 10 mL of ethyl acetate; washed with 10 mL each of 1 N HCl, 1 N NaOH and saturated NaCl; dried (MgS04) and

concentrated. Flash chromatography on silica gel (0-10% ethanol in ethyl acetate) gave the titled compound (12 mg, 9%). *H NMR (400 MHz, DMSO-<¾, 90°C) δ ppm 1.41 (dq, / = 38.8, 7.6 Hz, 4H), 1.75 - 1.89 (m, 2H), 2.00 (d, / = 8.2 Hz, 5H), 2.47 - 2.60 (m, 2H), 3.25 (dt, / = 16.2, 7.5 Hz, 5H), 3.73 (s, 6H), 6.46 (s, 2H), 7.03 - 7.16 (m, 3H), 7.16 - 7.27 (m, 2H), 7.40 (td, / = 5.2, 3.0 Hz, 1H), 7.80 - 7.91 (m, 2H), 8.50 (d, / = 4.7 Hz, 1H); MS (DCI) m/z 554 (M+H) ⁺ .

Example 142

3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(pyridine-3-sulfonyl)amin o]pentyl}-N-(3- phenylpropyl)benzamide

[001100] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (103 mg, 0.249 mmol, Example 4) and 1,1 '-carbonyldumidazole (64.6 mg, 0.399 mmol) in isopropyl acetate (2 mL) was stirred at 40 °C for 10 minutes. Pyridine-3-sulfonamide (51.2 mg, 0.324 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (75 μΕ, 0.498 mmol) were added, and the reaction mixture was stirred at 40 °C for 18 hours. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 N HC1 and saturated NaCl, dried with MgS0 ₄ and concentrated. Flash chromatography on silica gel (0-10% ethanol in ethyl acetate) gave the titled compound (32 mg, 23%). *H NMR (400 MHz, DMSO-<¾) δ ppm 1.42 (s, 6H), 1.98 (d, / = 1.8 Hz, 3H), 2.15 (d, / = 59.1 Hz, 2H), 2.38 (q, / = 6.5, 5.1 Hz, 1H), 2.59 (s, 1H), 3.09 (s, 5H), 3.72 (s, 6H), 6.46 (d, / = 11.4 Hz, 2H), 7.14 (t, / = 46.6 Hz, 5H), 7.60 (dd, / = 8.1, 4.8 Hz, 1H), 8.22 (s, 1H), 8.79 (dd, / = 4.8, 1.6 Hz, 1H), 8.99 (s, 1H); MS (DCI) m/z 554 (M+H) ⁺ .

Example 143

3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(pyridine-4-sulfonyl)amin o]pentyl}-N-(3- phenylpropyl)benzamide

[001101] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (108 mg, 0.261 mmol, Example 4) and Ι,Γ-carbonyldiimidazole (67.8 mg, 0.418 mmol) in isopropyl acetate (2 mL) was stirred at 40 °C for 10 minutes. Pyridine-4-sulfonamide (53.7 mg, 0.340 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (79 μL·, 0.522 mmol) were added, and the reaction mixture was stirred at 40 °C for 18 hours. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 N HC1 and saturated NaCl, dried with MgS0 ₄ and concentrated. Flash chromatography on silica gel (0-10% ethanol in ethyl acetate) gave the titled compound (59 mg, 41%). *H NMR (400 MHz, DMSO-<¾) δ ppm 1.01 - 1.27 (m, 2H), 1.46 (d, / = 37.5 Hz, 4H), 1.84 (s, 3H), 1.97 (d, / = 3.0 Hz, 5H), 2.38 (s, 1H), 2.60 (s, 1H), 3.09 (s, 2H), 3.72 (s, 6H), 6.46 (s, 2H), 6.86 - 7.40 (m, 5H), 7.60 (s, 2H), 8.54 - 8.67 (m, 2H); MS (DCI) m/z 554 (M+H) ⁺ .

Example 144

N- { 5- [(benzenesulfonyl) amino] -5 -oxopentyl } -3 ,5 -dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide [001102] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)arnino]pen tanoic acid (100 mg, 0.242 mmol, Example 4) and Ι ,Γ-carbonyldiimidazole (62.7 mg, 0.387 mmol) in isopropyl acetate (2 mL) was stirred at 40 °C for 10 minutes. Benzenesulfonamide (49.4 mg, 0.314 mmol) and l ,8-diazabicyclo[5.4.0]undec-7-ene (72.9 μL·, 0.484 mmol) were added, and the reaction mixture was stirred at 40 °C for 18 hours. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 N HC1 and saturated NaCl, dried with MgS0 ₄ and concentrated. Flash

chromatography on silica gel (0-50% ethyl acetate in heptane) gave the titled compound (15 mg, 11 %). *H NMR (400 MHz, DMSO-<¾) δ ppm 1.3 - 1.52 (m, 4H), 1.79 (d, / = 24.6 Hz, 2H), 1.98 (s, 3H), 2.05 - 2.43 (m, 4H), 2.58 (s, 1H), 3.08 (s, 2H), 3.72 (s, 6H), 6.44 (s, 2H), 7.13 (t, / = 47.0 Hz, 6H), 7.50 - 7.77 (m, 3H), 7.88 (d, / = 7.7 Hz, 2H), 12.03 (s, 1H); MS (DCI) m/z 553 (M+H) ⁺ .

Example 145

3-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]prop yl (4-fluorobenzene-l - sulfonyl)carbamate

[001103] Step 1 : N-(3-hydroxypropyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpropyl )benzamide

[001104] A mixture of 3-phenylpropylamine (0.563 mL, 3.95 mmol) and (3-bromopropoxy)(teri- butyl)dimethylsilane (0.897 mL, 3.95 mmol) in acetonitrile (20 mL) was heated to reflux for 2 hours and then cooled to room temperature to give 3-((teri-butyldimethylsilyl)oxy)-N-(3- phenylpropyl)propan-l -amine. Meanwhile, to a solution of 3,5-dimethoxy-4-methylbenzoic acid (0.775 g, 3.95 mmol) in N,N-dimethylformamide (10 mL) was added 1-

[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (1.501 g, 3.95 mmol, HATU) followed by Hunig's base (1.000 mL, 5.73 mmol). After stirring for 15 minutes, this solution was added to the solution of 3-((teri-butyldimethylsilyl)oxy)-N-(3- phenylpropyl)propan-l -amine. The reaction mixture was stirred at room temperature overnight. The crude mixture was concentrated and then partitioned between 1 M HC1 (-50 mL) and ethyl acetate (~50mL). The aqueous phase was extracted twice with ethyl acetate. The combined organic phases were washed with HC1 (2x), aqueous NaHC0 ₃ (2x) and brine, dried over MgS0 ₄ and concentrated. Flash chromatography on silica gel eluted with 0-100% i-butyl methyl ether in hexanes gave the titled compound (500 mg, 34.1 %) that was used directly in the next step. MS (DCI) m/z 372 (M+H) ⁺ .

[001105] Step 2: 3-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]prop yl (4- fluorobenzene- 1 -sulfonyl)carbamate

[001106] To a solution of N-(3-hydroxypropyl)-3,5-dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide (150 mg, 0.404 mmol,) in i-butyl methyl ether (10 mL) was added 4- fluorobenzenesulfonyl isocyanate (81 mg, 0.404 mmol) dropwise. The solution was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate, washed with brine, dried and concentrated. Flash chromatography on silica gel (0-100% i-butyl methyl ether/heptanes) gave the titled compound (173 mg, 75%). *H NMR (400 MHz, DMSO-<¾) δ ppm 0.67 - 0.91 (m, 2H), 1.17 (m, 2H), 1.78 (m, 4H), 1.96 (s, 3H), 2.36 (s, 1H), 3.12 (m, 2H), 3.71 (s, 6H), 4.00 (m, 1H), 6.46 (s, 2H), 6.85 - 7.33 (m, 5H), 7.33 - 7.51 (m, 2H), 7.80 - 8.07 (m, 2H), 12.04 (s, 1H); MS (DCI) m/z 573 (M+H) ⁺ .

Example 146

5-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}pentanoic acid

[001107] Step 1 : methyl 5-{ [3-(2,4-difluorophenyl)propyl]amino}pentanoate

[001108] In a 10 mL sealed tube was added Example 114-Step 2 (0.3 g, 1.752 mmol), methyl 5- bromopentanoate (0.410 g, 2.103 mmol), K ₂ C0 ₃ (0.291 g, 2.103 mmol) and acetonitrile (5 mL). The reaction mixture was stirred at reflux for 1 hour. The mixture was cooled to room temperature and filtered to remove potassium carbonate. The filtrate was concentrated to give the titled compound.

[001109] Step 2: methyl 5-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino jpentanoate

[001110] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (0.206 g, 1.051 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.426 g, 1.122 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.156 mL 1.122 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 146-Step 1 (0.5 g, 0.701 mmol) in CH ₃ CN (5 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic fractions were washed with saturated NaHC0 ₃ solution (1x10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue. The residue was added to a silica gel column that was eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.25 g, 0.485 mmol, 69.3% yield). LC-MS (ESI) m/z 464.2 (M+H) ⁺ , RT = 2.11 minutes.

[001111] Step 3: 5-{ [3-(2,4-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino jpentanoic acid

[001112] To a solution of Example 146-Step 2 (0.25 g, 0.539 mmol) in tetrahydrofuran (6 mL) was added 1 N LiOH (3.24 mL 3.24 mmol). The reaction mixture was heated to 50 °C for 2 hours. The reaction mixture was concentrated, and the remaining aqueous mixture was extracted with i-butyl methyl ether (5 mL). The aqueous mixture was cooled down and acidified with 1 N HC1 to pH=2~3. The aqueous mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H as buffer) and lyophilized to give the titled compound (0.105 g, 0.229 mmol, 42.4% yield). H NMR (400 MHz, DMSO-<¾, T = 20 °C) δ ppm 11.99 (brs, 1H), 7.45 - 6.80 (m, 3H), 6.55 - 6.35 (m, 2H), 3.80 - 3.68 (m, 6H), 3.62 - 3.55 (m, 2H), 3.24 - 3.02 (m, 2H), 2.68 - 2.54 (m, 1H), 2.44 - 2.32 (m, 1H), 2.28 - 2.20 (m, 1H), 2.14 - 2.02 (m, 1H), 1.97 (s, 3H), 1.90 - 1.67 (m, 2H), 1.62 - 1.42 (m, 3H), 1.41 - 1.21 (m, 1H); LC-MS (ESI) m/z 450.2 (M+H) ⁺ , RT = 1.96 minutes.

Example 147

5-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}pentanoic acid

[001113] Step 1 : methyl 5-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino jpentanoate

[001114] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (0.248 g, 1.262 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.512 g, 1.346 mmol, HATU) in N,N-dimethylformamide (5 mL) was added triethylamine (0.188 mL 1.346 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 137-Step 1 (0.6 g, 0.841 mmol) in CH ₃ CN (5 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic fractions were washed with saturated NaHC0 ₃ solution (1x10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue. The residue was added to a silica gel column that was eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.3 g, 0.583 mmol, 69.3% yield). LC-MS (ESI) m/z 464.2 (M+H) ⁺ , RT = 2.11 minutes.

[001115] Step 2: 5-{ [3-(2,6-difluorophenyl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino jpentanoic acid

[001116] To a solution of Example 147-Step 1 (0.3 g, 0.647 mmol) in tetrahydrofuran (6 mL) was added 1 N LiOH (3.88 mL 3.88 mmol). The reaction mixture was heated to 50 °C for 2 hours. The reaction mixture was concentrated, and the remaining aqueous mixture was extracted with i-butyl methyl ether (5 mL). The mixture was cooled down and acidified with 1 N HC1 to pH=2~3. The acidic aqueous mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue which was precipitated from CH ₃ CN (2 mL) to give the titled compound (0.15 g, 0.320 mmol, 49.5% yield). *H NMR (400 MHz, DMSO-<¾, T = 20 °C) δ ppm 12.01 (s, 1H), 7.36 - 7.16 (m, 1H), 7.12 - 6.82 (m, 1H), 6.54 - 6.36 (m, 2H), 3.78 - 3.66 (m, 6H), 3.46

- 3.34 (m, 2H), 3.22 - 3.06 (m, 2H), 2.72 - 2.60 (m, 1H), 2.46 - 2.36 (m, 1H), 2.30 - 2.20 (m, 1H), 2.14

- 2.02 (m, 1H), 1.96 (s, 3H), 1.88 - 1.68 (m, 2H), 1.62 - 1.42 (m, 3H), 1.34 - 1.22 (m, 1H); LC-MS (ESI) m/z 450.2 (M+H) ⁺ , RT = 1.95 minutes.

Example 148

5-{(3,5-dimethoxybenzoyl)[3-(4-fluorophenyl)propyl]amino}pen tanoic acid

[001117] Step 1 : methyl 5- { [3 -(4-fluorophenyl)propyl] amino jpentanoate [001118] To a 10 mL sealed tube was added 3-(4-fluorophenyl)propan-l -amine (0.3 g, 1.958 mmol), methyl 5-bromopentanoate (0.382 g, 1.958 mmol), K ₂ C0 ₃ (0.271 g, 1.958 mmol) and acetonitrile (5 mL). The reaction mixture was stirred at reflux for 1 hour. The mixture was cooled to room temperature and filtered to remove potassium carbonate. The filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 268.2 (M+H) ⁺ , RT = 1.52 minutes.

[001119] Step 2: methyl 5-{(3,5-dimethoxybenzoyl)[3-(4-fluorophenyl)propyl]amino}pen tanoate

[001120] To a solution of 3,5-dimethoxybenzoic acid (0.153 g, 0.842 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (0.341 g, 0.898 mmol, HATU) in NN-dimethylformamide (5 mL) was added triethylamine (0.125 mL 0.898 mmol). The resulting solution was stirred at room temperature for 10 minutes. Then a solution of Example 148-Step 1 (0.5 g, 0.561 mmol) in CH ₃ CN (5 mL) was added in one portion. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and extracted with ethyl acetate twice. The combined organic fractions were washed with saturated NaHC0 ₃ solution (1x10 mL) and brine, dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue. The residue was added to a silica gel column that was eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (0.25 g, 0.521 mmol, 93% yield). LC-MS (ESI) m/z 432.2 (M+H) ⁺ , RT = 2.01 minutes.

[001121] Step 3: 5-{(3,5-dimethoxybenzoyl)[3-(4-fluorophenyl)propyl]amino}pen tanoic acid

[001122] To a solution of Example 148-Step 2 (0.25 g, 0.579 mmol) in tetrahydrofuran (3 mL) was added 1 N LiOH (0.579 mL 0.579 mmol). The reaction mixture was heated to 50 °C for 2 hours. The reaction mixture was concentrated, and the remaining aqueous mixture was extracted with i-butyl methyl ether (5 mL). The aqueous mixture was then acidified with 1 N HC1 to pH=2~3. The acidic aqueous mixture was extracted with ethyl acetate twice, and the combined organic layers were concentrated to give a residue which was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H as buffer) and lyophilized to give the titled compound (0.085 g, 0.200 mmol, 34.4% yield). H NMR (400 MHz, DMSO-<¾) δ ppm 12.01 (s, 1H), 7.27 (t, J = 6.8 Hz, 1H), 7.04 (ddd, J = 28.9, 20.5, 8.7 Hz, 3H), 6.49 (d, J = 13.5 Hz, 1H), 6.36 (d, J = 19.1 Hz, 2H), 3.89 - 3.57 (m, 6H), 3.50 - 3.37 (m, 2H), 3.18 - 3.02 (m, 2H), 2.64 - 2.54 (m, 1H), 2.42 - 2.33 (m, 1H), 2.28 - 2.20 (m, 1H), 2.12 - 2.02 (m, 1H), 1.90 - 1.68 (m, 2H), 1.62 - 1.35 (m, 3H), 1.37 - 1.14 (m, 1H); LC-MS (ESI) m/z 418.2 (M+H) ⁺ , RT = 1.87 minutes.

Example 149

5-{ [2-ethoxy-l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3-phen ylpropyl)amino}pentanoic acid

[001123] Step 1 : methyl 5-[(teri-butoxycarbonyl)(3-phenylpropyl)amino]pentanoate

[001124] A solution of methyl 5-bromopentanoate (4.00 g, 20.51 mmol) in acetonitrile (40 mL) was heated to reflux, and then a solution of 3-phenylpropan-l -amine (2.77 g, 20.51 mmol) in acetonitrile (5 mL) was added to the mixture. The mixture was heated to reflux for 1 hour. The mixture was cooled to 0 °C, di-teri-butyl dicarbonate (4.48 g, 20.51 mmol) was added to the mixture and triethylamine (2.075 g, 20.51 mmol) was added subsequently. The mixture was stirred at room temperature for 30 minutes and then concentrated to dryness. The residue was purified by flash chromatography with 0-20% ethyl acetate/hexane to give the titled compound (3.00 g, 8.58 mmol, 41.9% yield). LC-MS (ESI) m/z 250.5 (M-C0 ₂ C(CH ₃ ) ₃ +H) ⁺ , RT = 2.18 minutes.

[001125] Step 2: methyl 5-[(3-phenylpropyl)amino]pentanoate-hydrogen chloride

[001126] A solution of Example 149-Step 1 (1.20 g, 3.43 mmol) in 4 N HCl in 1,4-dioxane (12 mL) was stirred at room temperature for 30 minutes. Then the mixture was concentrated to dryness under vacuum to give the titled compound (980 mg, 3.43 mmol, 100% yield) as a HCl salt. LC-MS (ESI) m/z 250.5 (M+H) ⁺ , RT = 1.48 minutes.

[001127] Step 3: methyl 2-ethoxy-l-(4-methoxyphenyl)cyclopropane-l-carboxylate

[001128] To a solution of ethoxyethene (0.157 g, 2.182 mmol) and diacetoxyrhodium (0.026 g, 0.058 mmol) in 5 mL of 2,2-dimethyl butane was added dropwise methyl 2-diazo-2-(4- methoxyphenyl)acetate (0.15 g, 0.727 mmol) in 2,2-dimethylbutane (50 mL) treated with 2 mg of diacetoxyrhodium (2.144 mg, 4.85 μπιοΐ). The mixture was allowed to stir at 25 °C for 30 minutes and was then concentrated under reduced pressure. Chromatography of the resulting residue on flash column (eluent, ethyl acetate/hexane from 0/100 to 20/80) gave the titled compound. ¾ NMR (400 MHz, CDC1 ₃ ) δ ppm 7.35 - 7.20 (m, 2H), 6.94 - 6.76 (m, 2H), 3.93 - 3.86 (m, 1H), 3.81 (s, 3H), 3.63 (s, 3H), 3.58 (pd, J = 5.4, 4.7, 2.1 Hz, 2H), 1.78 (dd, J = 7.1, 5.7 Hz, 1H), 1.57 (d, J = 10.3 Hz, 1H), 1.03 (t, J = 7.0 Hz, 3H).

[001129] Step 4: 2-ethoxy-l-(4-methoxyphenyl)cyclopropane-l-carboxylic acid

[001130] A mixture of Example 149-Step 3 (30 mg, 0.120 mmol), lithium hydroxide hydrate (20.12 mg, 0.479 mmol), water (1 mL) and tetrahydrofuran (1 mL) was stirred at 40 °C for 2 hours. The mixture was acidified to pH =4 with 1 N HCl. The mixture was extracted with ethyl acetate (3x20 mL). The organic layers were combined, washed with brine, dried with Na ₂ S0 ₄ and concentrated to dryness to give the titled compound. Ή NMR (400 MHz, CDC1 ₃ ) δ ppm 7.30 - 7.27 (m, 2H), 6.92 - 6.84 (m, 2H), 3.97 - 3.92 (m, 1H), 3.81 (d, J = 1.6 Hz, 3H), 3.62 - 3.55 (m, 2H), 1.84 (dd, J = 7.1, 5.8 Hz, 1H), 1.65 (dd, J = 5.8, 4.8 Hz, 1H), 1.03 (t, J = 7.0 Hz, 3H).

[001131] Step 5: methyl 5-{ [2-ethoxy-l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino } pentanoate

[001132] A mixture of Example 149-Step 4 (35 mg, 0.148 mmol), 2-(3H-[l,2,3]triazolo[4,5- ¾]pyridin-3-yl)-l,l,3,3-tetramethylisouronium hexafluorophosphate(V) (56.3 mg, 0.148 mmol), Example 149-Step 2 (50.8 mg, 0.178 mmol), NN-dimethylformamide (2 mL) and N-ethyl-N- isopropylpropan-2-amine (57.4 mg, 0.444 mmol) was stirred at 25 °C for 2 hours. The reaction was quenched with water. The mixture was extracted with ethyl acetate (2x20 mL). The combined organic fractions were washed with brine (2x30 mL), and dried over Na ₂ S0 ₄ , and concentrated to give the titled compound. LC-MS (ESI) m/z 468.4 (M+H) ⁺ , RT = 2.096 minutes.

[001133] Step 6: 5-{ [2-ethoxy-l-(4-methoxyphenyl)cyclopropane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid

[001134] A mixture of Example 149-Step 5 (35 mg, 0.075 mmol), lithium hydroxide hydrate (12.57 mg, 0.299 mmol), water (1 mL) and tetrahydrofuran (1 mL) was stirred at 25 °C for 2 hours. The mixture was acidified to pH =4 with 1 N HC1. The mixture was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in water/CH ₃ CN) to give the titled compound. ¾ NMR (400 MHz, methanol- ¾ δ ppm 7.25 (ddd, J = 7.5, 5.5, 3.4 Hz, 3H), 7.21 - 7.12 (m, 2H), 7.10 - 7.06 (m, 1H), 7.01 - 6.97 (m, 1H), 6.92 - 6.83 (m, 2H), 3.83 - 3.75 (m, 4H), 3.42 (ddt, J = 14.2, 9.2, 7.1 Hz, 1H), 3.29 - 3.15 (m, 4H), 2.57 (t, J = 7.8 Hz, 1H), 2.40 - 2.22 (m, 1H), 2.18 - 2.12 (m, 1H), 1.96 (p, J = 7.7, 7.1 Hz, 1H), 1.81 (ddt, J = 19.6, 8.9, 6.4 Hz, 1H), 1.63 - 1.41 (m, 4H), 1.32 (td, J = 9.8, 9.2, 4.1 Hz, 1H), 1.28 - 1.09 (m, 2H), 0.82 (dt, J = 13.9, 7.0 Hz, 4H); LC-MS (ESI) m/z 454.4 (M+H) ⁺ , RT = 1.940 minutes.

Example 150

3,5-dimethoxy-4-methyl-N-{5-oxo-5-[(trifluoromethanesulfonyl )amino]pentyl}-N-(3- phenylpropyl)benzamide

[001135] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (100 mg, 0.242 mmol, Example 4) and Ι,Γ-carbonyldiimidazole (62.7 mg, 0.387 mmol) in isopropyl acetate (2 mL) was stirred at 50 °C for 20 minutes. Trifluoromethanesulfonamide (46.9 mg, 0.314 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (72.9 μL·, 0.484 mmol) were added, and the reaction mixture was stirred at 50 °C for 18 hours. Additional trifluoromethanesulfonamide (5 mg, 0. 03 mmol) was added, and the reaction mixture was stirred at 60 °C for 1 hour. The reaction mixture was diluted with 10 mL of ethyl acetate; washed with 10 mL of 1 N HC1, IN NaOH, and saturated NaCl; dried with MgS0 ₄ and concentrated. Two rounds of flash chromatography on silica gel (100% ethyl acetate) gave the titled compound (12 mg, 9%). Ή NMR (501 MHz, DMSO-<¾) δ ppm 1.27 (s, 1H), 1.51 (s, 3H), 1.89 (s, 2H), 1.97 (d, / = 5.4 Hz, 3H), 2.10 (d, / = 4.0 Hz, 1H), 2.34 (m, 2H), 2.62 (m, iH), 3.13 (m, 2H), 3.37 (m, 3H), 3.74 (s, 6H), 6.47 (s, 2H), 6.93 - 7.39 (m, 5H); MS (DCI) m/z 544 (M+H) ⁺ .

Example 151

5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] -2-hydroxypentanoic acid

[001136] Step 1 : methyl 2-(acetyloxy)-5-iodopentanoate

[001137] To a mixture of methyl tetrahydrofuran-2-carboxylate (1 g, 7.68 mmol) and sodium iodide (2.304 g, 15.37 mmol) in dry CH ₃ CN (10 mL) cooled in an ice-water bath was added, dropwise, acetyl chloride (1.093 mL 15.37 mmol). Then the mixture was stirred for 24 hours at room temperature. The mixture was quenched with saturated NaHC0 ₃ (10 mL), much bubbling occurred, and the suspension became clear. The aqueous fraction was separated and extracted with i-butyl methyl ether 3 times. The combined organic layers were washed with brine and saturated NaHS0 ₃ once, dried, and concentrated to give the titled compound (1.989 g, 6.63 mmol, 86% yield) as a light yellow oil. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 5.07 - 5.00 (m, 1H), 3.76 (s, 3H), 3.27 - 3.15 (m, 2H), 2.15 (s, 3H), 1.99 - 1.87 (m, 4H).

[001138] Step 2: methyl 2-(acetyloxy)-5-[(3-phenylpropyl)amino]pentanoate

[001139] A mixture of 3-phenylpropan-l -amine (162 mg, 1.196 mmol) and Example 151-Step 1 (359 mg, 1.196 mmol) in CH ₃ CN (3 mL) was stirred at reflux for 40 minutes. The solution was cooled down and concentrated to give the titled compound. LC-MS (ESI) m/z 308.2 (M+H) ⁺ , RT = 1.541 minutes.

[001140] Step 3: methyl 2-(acetyloxy)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] pentanoate

[001141] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (235 mg, 1.196 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (500 mg, 1.316 mmol, HATU) in N,N-dimethylformamide (6 mL) was added triethylamine (0.183 mL 1.316 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 151-Step 2 (368 mg, 1.196 mmol) and triethylamine (1 mL) in CH ₃ CN (3 mL) was added to the reaction system. The mixture was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (127 mg, 0.201 mmol, 16.84% yield). LC-MS (ESI) m/z 486.2 (M+H) ⁺ , RT = 2.084 minutes.

[001142] Step 4: 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2-h ydroxypentanoic acid

[001143] To a solution of Example 151-Step 3 (127 mg, 0.262 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (2.62 mL 2.62 mmol). The mixture was stirred at room temperature overnight. The mixture was acidified with 1 N HC1 to pH=2~3 and extracted with ethyl acetate once. The organic layer was concentrated. The residue was purified by preparative HPLC (0.1 %

NH ₃ H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (45 mg, 0.105 mmol, 40.1% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.22 (t, J = 7.6 Hz, 2H), 7.19 - 7.00 (m, 3H), 6.49 (s, 2H), 3.76 (s, 6H), 3.64 (s, 1H), 3.28 (s, 4H), 2.51 (d, J = 12.8 Hz, 2H), 2.00 (s, 3H), 1.85 (t, J = 7.7 Hz, 2H), 1.61 (dd, J = 15.2, 7.3 Hz, 2H), 1.52 (s, 1H), 1.37 (s, 1H); LC-MS (ESI) m/z 430.2 (M+H) ⁺ , RT = 1.849 minutes. Example 152

5-{ [l-(4-methoxyphenyl)-3-oxocyclobutane-l-carbonyl](3-phenylpr opyl)amino}pentanoic acid

[001144] Step 1 : methyl 5-[(teri4jutoxycarbonyl)(3-phenylpropyl)amino]pentanoate

[001145] A solution of methyl 5-bromopentanoate (25 g, 128 mmol) in acetonitrile (200 mL) was heated to reflux, and then a solution of 3-phenylpropan-l -amine (19.06 g, 141 mmol) in acetonitrile (5 mL) was added dropwise to the mixture. The mixture was heated to reflux for 0.5 hour, and then was cooled to 0 °C. Di-teri-butyl dicarbonate (30.8 g, 141 mmol) was added to the mixture and triethylamine (12.97 g, 128 mmol) was subsequently added. The mixture was stirred at room temperature for 30 minutes and then concentrated to dryness. The residue was diluted with H ₂ 0 (100 mL) and extracted with ethyl acetate (300 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated. The residue was purified by flash chromatography with hexane and ethyl acetate (0-10%) to give the titled compound (14.0 g, 40.1 mmol, 31.3% yield). LC-MS (ESI) m/z 250 (M+H) ⁺ , RT = 2.19 minutes.

[001146] Step 2: methyl 5-[(3-phenylpropyl)amino]pentanoate

[001147] To a solution of Example 152-Step 1 (2.0 g, 5.72 mmol) in CH ₂ C1 ₂ (6.5 mL) was added CF ₃ C0 ₂ H (2.126 mL 28.6 mmol). The solution was stirred at room temperature for 1.5 hours. Then triethylamine (8 mL) was added to quench the solution to pH>9. The resulting solution was concentrated to give the titled compound. LC-MS (ESI) m/z 250.2 (M+H) ⁺ , RT = 1.474 minutes.

[001148] Step 3: methyl 5-{ [l-(4-methoxyphenyl)-3-oxocyclobutane-l-carbonyl](3- phenylpropyl) amino } pentanoate

[001149] Example 152-Step 2 (50 mg, 0.143 mmol) and l-(4-methoxyphenyl)-3- oxocyclobutanecarboxylic acid (31.5 mg, 0.143 mmol) were dissolved in N,N-dimethylformamide (3 mL), and l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyr idinium 3-oxid

hexafluorophosphate (54.4 mg, 0.143 mmol, HATU) and diisopropylethylamine (0.050 mL 0.286 mmol) were added thereto. The resulting solution was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate twice. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give the titled compound (50 mg, 0.111 mmol, 77% yield). LC-MS (ESI) m/z 452 (M+H) ⁺ , RT = 2.036 minutes.

[001150] Step 4: 5-{ [l-(4-methoxyphenyl)-3-oxocyclobutane-l-carbonyl](3- phenylpropyl) amino jpentanoic acid

[001151] A mixture of Example 152-Step 3 (30 mg, 0.066 mmol), 1 N lithium hydroxide (0.5 mL 0.500 mmol), and dioxane (0.5 mL) was stirred at 30 °C for 2 hours. The mixture was acidified to pH =6-7 with 1 N HC1, and then the product was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in water/CH ₃ CN) to give the titled compound (2.5 mg, 5.71 μιηοΐ, 8.60% yield). H NMR (400 MHz, methanol-^) δ ppm 7.34 - 7.03 (m, 6H), 7.03 - 6.83 (m, 3H), 3.93 - 3.69 (m, 4H), 3.43 - 3.24 (m, 4H), 3.17 - 3.07 (m, 1H), 3.04 - 2.88 (m, 2H), 2.59 (q, J = 9.8, 8.8 Hz, 1H), 2.29 (dq, J = 13.4, 6.9 Hz, 2H), 2.01 (t, J = 7.4 Hz, 1H), 1.86 (dp, J = 14.2, 7.8 Hz, 1H), 1.57 (dt, J = 12.1, 5.8 Hz, 2H), 1.37 (p, J = 7.8 Hz, 1H), 1.19 (p, J = 7.4 Hz, 1H), 0.99 (tt, J = 11.6, 6.2 Hz, 1H); LC-MS (ESI) m/z 438 (M+H) ⁺ , RT = 1.876 minutes.

Example 153

5-{(3,5-dimethoxy-4-methylbenzoyl)[(2R)-4-phenylbutan-2-yl]a mino}pentanoic acid

[001152] Step 1 : methyl 5-{ [(2R)-4-phenylbutan-2-yl]amino}pentanoate

[001153] (R)-4-Phenylbutan-2-amine (200 mg, 1.340 mmol) and potassium carbonate (222 mg, 1.608 mmol) were dissolved in dry CH ₃ CN (6 mL) at room temperature. Methyl 5-bromopentanoate (288 mg, 1.474 mmol) dissolved in dry CH ₃ CN was added slowly to the mixture, and then the mixture was stirred at reflux for 3 hours. The mixture was cooled down and filtered. The filtrate was concentrated to give the titled compound (230 mg, 0.873 mmol, 65.2% yield).

[001154] Step 2: methyl 5-{(3,5-dimethoxy-4-methylbenzoyl)[(2R)-4-phenylbutan-2- yl] amino } pentanoate

[001155] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (235 mg, 1.196 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (500 mg, 1.316 mmol, HATU) in N,N-dimethylformamide (6 mL) was added triethylamine (0.183 mL 1.316 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 153-Step 1 (314 mg, 1.196 mmol) and triethylamine (1 mL) in CH ₃ CN (3 mL) was added to the reaction system. The mixture was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (88 mg, 0.201 mmol, 16.8% yield).

[001156] Step 3: 5-{(3,5-dimethoxy-4-methylbenzoyl)[(2R)-4-phenylbutan-2-yl]a mino}pentanoic acid

[001157] Example 153-Step 2 (260 mg, 0.589 mmol) was dissolved in tetrahydrofuran (2 mL) and lithium hydroxide (85 mg, 3.53 mmol) solution (2 mL) was added. The mixture was stirred for 12 hours at room temperature. The mixture was poured into water; the pH was adjusted to 4 with 1 N HCl and extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1%

CF ₃ C0 ₂ H in water/CH ₃ CN) to give the titled compound (200 mg, 0.468 mmol, 79% yield). Ή NMR (400 MHz, DMSO-<¾) δ ppm 7.36 - 6.96 (m, 5H), 6.48 (s, 2H), 3.75 (s, 6H), 3.14 (s, 1H), 2.38 (s, 2H), 2.26 (s, 2H), 1.98 (s, 3H), 1.85 - 1.46 (m, 5H), 1.15 (d, J = 6.6 Hz, 4H); LC-MS (ESI) m/z 428.2 (M+H) ⁺ . Example 154

5-{(3,5-dimethoxy-4-methylbenzoyl)[(25)-4-phenylbutan-2-yl]a mino}pentanoic acid

[001158] Step 1 : methyl 5-{ [(25)-4-phenylbutan-2-yl]amino}pentanoate

[001159] (5)-4-Phenylbutan-2-amine (200 mg, 1.340 mmol) and potassium carbonate (222 mg, 1.608 mmol) were dissolved in dry CH ₃ CN (6 mL) at room temperature. Methyl 5-bromopentanoate (288 mg, 1.474 mmol) dissolved in dry CH ₃ CN was added slowly to the mixture, and then the mixture was stirred at reflux for 3 hours. The mixture was cooled down and filtered. The filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 264.2 (M+H) ⁺ .

[001160] Step 2: methyl 5-{(3,5-dimethoxy-4-methylbenzoyl)[(25)-4-phenylbutan-2- yl] amino } pentanoate

[001161] 3,5-Dimethoxy-4-methylbenzoic acid (263 mg, 1.340 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (611 mg, 1.608 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (520 mg, 4.02 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 154-Step 1 (353 mg, 1.34 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (271 mg, 0.614 mmol, 45.8% yield).

[001162] Step 3: 5-{(3,5-dimethoxy-4-methylbenzoyl)[(25)-4-phenylbutan-2-yl]a mino}pentanoic acid

[001163] Example 154-Step 2 (265 mg, 0.600 mmol) was dissolved in tetrahydrofuran (2 mL) and lithium hydroxide (86 mg, 3.60 mmol) solution (2 mL) was added. The mixture was stirred for 12 hours at room temperature. The mixture was poured into water, the pH was adjusted to 5, and the mixture was extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in water/CH ₃ CN) to give the titled compound (186 mg, 0.435 mmol, 72.5% yield). H NMR (400 MHz, DMSO-<¾) δ ppm 7.36 - 6.96 (m, 5H), 6.48 (s, 2H), 3.75 (s, 6H), 3.14 (s, 1H), 2.38 (s, 2H), 2.26 (s, 2H), 1.98 (s, 3H), 1.85 - 1.46 (m, 5H), 1.15 (d, J = 6.6 Hz, 4H); LC-MS (ESI) m/z 428.2 (M+H) ⁺ .

Example 155

5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] -2-hydroxy-2-methylpentanoic acid

[001164] Step 1 : methyl 2-(acetyloxy)-5-iodo-2-methylpentanoate [001165] To a mixture of methyl 2-methyltetrahydrofuran-2-carboxylate (300 mg, 2.081 mmol) and sodium iodide (624 mg, 4.16 mmol) in dry CH ₃ CN (3 mL) cooled in an ice-water bath was added, dropwise, acetyl chloride (0.296 mL 4.16 mmol). Then the mixture was stirred for 24 hours at room temperature. The mixture was quenched with saturated NaHC0 ₃ (4 mL) and much bubbling was noted as the suspension became clear. The aqueous fraction was separated and extracted with i-butyl methyl ether 3 times. The combined organic fractions were washed with brine and saturated NaHS0 ₃ once, dried, and concentrated to give the titled compound (376 mg, 1.197 mmol, 57.5% yield).

NMR (400 MHz, CDC1 ₃ ) δ ppm 3.74 (s, 3H), 3.18 (dt, J = 6.5, 3.0 Hz, 2H), 2.07 (s, 3H), 1.95 - 1.88 (m, 4H), 1.58 (s, 3H).

[001166] Step 2: methyl 2-(acetyloxy)-2-methyl-5-[(3-phenylpropyl)amino]pentanoate

[001167] A mixture of 3-phenylpropan-l -amine (232 mg, 1.714 mmol) and Example 155-Step 1 (359 mg, 1.143 mmol) in CH ₃ CN (3 mL) was stirred at reflux for 30 minutes. The solution was cooled down and concentrated to give the titled compound. LC-MS (ESI) m/z 322.2 (M+H) ⁺ , RT = 1.550 minutes.

[001168] Step 3: methyl 2-(acetyloxy)-5-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl)amino]-2-methylpentanoate

[001169] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (336 mg, 1.714 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (717 mg, 1.885 mmol, HATU) in N,N-dimethylformamide (8 mL) was added triethylamine (0.263 mL 1.885 mmol). The resultant mixture was stirred at room temperature for 30 minutes. A solution of Example 155-Step 2 (551 mg, 1.714 mmol) and triethylamine (1 mL) in CH ₃ CN (3.0 mL) was added to the reaction system. The mixture was stirred at room temperature for 1 hour. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (224 mg, 0.448 mmol, 26.2% yield). LC-MS (ESI) m/z 500.2 (M+H) ⁺ , RT = 2.124 minutes.

[001170] Step 4: 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2-h ydroxy-2- methylpentanoic acid

[001171] To a solution of Example 155-Step 3 (224 mg, 0.448 mmol) in tetrahydrofuran (4 mL) was added 1 N lithium hydroxide (4.48 mL 4.48 mmol). The mixture was stirred at room temperature overnight. The mixture was concentrated under vacuum and washed with i-butyl methyl ether 3 times. Then the aqueous fraction was acidified with 1 N HC1 to pH=2-3 and extracted with ethyl acetate once. The organic layer was concentrated. The residue was purified by preparative HPLC (0.1% NH ₃ in H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (110 mg, 0.248 mmol, 55.3% yield). *H NMR (400 MHz, DMSO-<¾) 5 ppm 7.30 - 7.11 (m, 4H), 7.02 (s, 1H), 6.91 (s, 1H), 6.47 (s, 2H), 3.75 (d, J = 4.1 Hz, 6H), 3.32 (d, J = 29.5 Hz, 2H), 3.10 (d, J = 19.5 Hz, 2H), 2.61 (s, 1H), 2.39 (s, 1H), 1.98 (s, 3H), 1.86 (s, 1H), 1.78 (s, 1H), 1.60 (s, 1H), 1.37 (s, 2H), 1.14 (s, 2H), 1.06 (s, 2H); LC-MS (ESI) m/z 444.2 (M+H) ⁺ , RT = 1.891 minutes.

Example 156

N-[2-( { 1 -[(methanesulfonyl) amino] -2-methyl- 1 -oxopropan-2-yl }oxy)ethyl] -3,5-dimethoxy-4-methyl-

N-(3 -phenylpropyl)benzamide

[001172] A mixture of 2-{2-[(3,5-dimethoxy-4-methylbenzoyl)(3^henylpropyl)arnino]e thoxy}-2- methylpropanoic acid (20 mg, 0.045 mmol, Example 55) and 1 , Γ-carbonyldiimidazole (11.70 mg, 0.072 mmol) in isopropyl acetate (2 mL) was stirred at 50 °C for 25 minutes. Methanesulfonamide (6.86 mg, 0.072 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (10.87 μΕ, 0.072 mmol) were added, and the reaction mixture was stirred at 50 °C overnight. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 N HC1 and saturated NaCl, dried with MgS0 ₄ and concentrated. The residue was re -dissolved in isopropyl acetate (2 mL) and treated with 1,1'- carbonyldiimidazole (11.70 mg, 0.072 mmol) and stirred at 40 °C for 30 minutes. Then more methanesulfonamide (6.86 mg, 0.072 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (10.87 μΕ, 0.072 mmol) were added, and the mixture was stirred at 50 °C overnight. The reaction mixture was diluted with 10 mL of ethyl acetate, washed with 10 mL of 1 N HC1 and saturated NaCl, dried with MgS0 ₄ and concentrated. Flash chromatography on silica gel (100% ethyl acetate) gave the titled compound (4 mg, 18%). 'H NMR (501 MHz, CDC1 ₃ ) δ ppm 0.81 - 1.02 (m, 6H), 1.37 (d, / = 84.7 Hz, 2H), 1.94 (s, 2H), 2.13 (s, 3H), 2.53 (s, 2H), 3.34 (s, 2H), 3.71 (d, / = 29.8 Hz, 4H), 3.83 (s, 7H), 6.54 (s, 2H), 7.07 (d, / = 9.2 Hz, 2H), 7.16 - 7.29 (m, 3H), 10.02 (s, 1H); MS (DCI) m/z 521 (M+H) ⁺

Example 157

N-(2-{2-[(methanesulfonyl)amino]-2-oxoethoxy}ethyl)-3,5-dime thoxy-4-methyl-N-(3- phenylpropyl)benzamide

[001173] A 4 mL vial was charged with {2-[(3,5-dimethoxy-4-methylbenzoyl)(3- phenylpropyl) amino] ethoxy} acetic acid (0.1 g, 0.241 mmol, Example 6), tetrahydrofuran (2 mL) and l,l'-carbonyldiimidazole (0.047 g, 0.289 mmol). The vial was capped and heated at 50 °C for 1 hour. Methanesulfonamide (0.025 g, 0.265 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (0.073 mL, 0.481 mmol) were added and heating was continued for 2 hours. The mixture was diluted with CHC1 ₃ (10 mL) and shaken with 1 M HC1 (10 mL). The lower organic layer was isolated using a Biotage® phase separator column (#120-1905C) and concentrated. The product was isolated using preparative HPLC followed by flash chromatography on silica gel (30-100% ethyl acetate/heptane) to give the titled compound (0.048 g, 0.097 mmol, 40.5 % yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.16- 7.24 (3H, m), 7.01 (2H, s, br), 6.51 (2H, s), 4.09 (2H, s, br), 3.81 (6H, s), 3.70 (2H, s, br), 3.34 (2H, s, br), 3.28 (3H, s), 2.51 (2H, s, br), 2.10 (3H, s), 1.91 (2H, s, br); MS (APCI ⁺ ) m/z 493.3 (M+H) ⁺ .

Example 158

5-{ [cis -3 -methoxy- 1 -(4-methoxyphenyl)cyclobutane- 1 -carbonyl] (3-phenylpropyl)amino jpentanoic acid

[001174] Step 1 : methyl 5-{ [l-(4-methoxyphenyl)-3-oxocyclobutane-l-carbonyl](3- phenylpropyl) amino } pentanoate

[001175] A mixture of l-(4-methoxyphenyl)-3-oxocyclobutanecarboxylic acid (100 mg, 0.485 mmol), 2-(3H-[l,2,3]triazolo[4,5-¾]pyridin-3-yl)-l,l,3,3-tetrameth ylisouronium

hexafluorophosphate(V) (184 mg, 0.485 mmol), Example 70-Step 1 (139 mg, 0.485 mmol), N,N- dimethylformamide (2 mL) and N-ethyl-N-isopropylpropan-2-amine (188 mg, 1.455 mmol) was stirred at 25 °C for 2 hours. The reaction was quenched with water, and the mixture was extracted with ethyl acetate (2x20 mL). The combined organic fractions were washed with brine (2x30 mL), dried over Na ₂ S0 ₄ , and concentrated to give a residue which was purified by flash column

chromatography on silica gel (eluent, ethyl acetate/hexane from 0/10 to 1/2 ) to afford the titled compound. ^l U NMR (400 MHz, CDC1 ₃ ) δ ppm 7.31 - 7.27 (m, 2H), 7.25 - 7.17 (m, 3H), 7.07 - 7.03 (m, 1H), 6.97 - 6.94 (m, 1H), 6.90 - 6.84 (m, 2H), 3.81 (d, J = 3.4 Hz, 3H), 3.65 (d, J = 11.5 Hz, 3H), 3.35 (ddd, J = 14.2, 7.0, 4.2 Hz, 2H), 3.15 - 2.99 (m, 2H), 2.93 - 2.85 (m, 2H), 2.63 (t, J = 7.8 Hz, 1H), 2.32 (dt, J = 24.7, 7.0 Hz, 3H), 2.05 (t, J = 7.4 Hz, 1H), 1.94 - 1.80 (m, 1H), 1.44 - 1.35 (m, 2H), 1.27 - 1.15 (m, 2H), 1.02 (p, J = 8.8, 8.0 Hz, 2H); LC-MS (ESI) m/z 452.2 (M+H) ⁺ , RT = 2.042 minutes.

[001176] Step 2: methyl 5-{ [3-hydroxy-l-(4-methoxyphenyl)cyclobutane-l-carbonyl](3- phenylpropyl) amino } pentanoate

[001177] To a mixture of Example 158-Step 1 (0.05 g, 0.100 mmol) in CH ₃ OH (5 mL) was added portionwise sodium tetrahydroborate (3.77 mg, 0.100 mmol) at 0 °C. The mixture was stirred at 0 °C for 1.5 hours. The mixture was quenched with water and extracted with ethyl acetate (3x20 mL). The combined organic phases were washed with brine (2x30 mL), dried over Na ₂ S0 ₄ , and concentrated to give the titled compound. LC-MS (ESI) m/z 454.2 (M+H) ⁺ , RT = 1.928 minutes.

[001178] Step 3: 5-{ [c 5 ^, -3-methoxy-l-(4-methoxyphenyl)cyclobutane-l-carbonyl]( 3- phenylpropyl) amino jpentanoic acid

[001179] To a mixture of Example 158-Step 2 (55 mg, 0.121 mmol) in N,N-dimethylformamide (2 mL) was added portionwise sodium hydride (9.70 mg, 0.243 mmol) at 0 °C. The mixture was stirred at 0 °C for 10 minutes. Iodomethane (0.023 mL 0.364 mmol) was added to the mixture at 0 °C. The mixture was stirred at room temperature for 3 hours. The mixture was quenched with water (2 mL). To the mixture was added lithium hydroxide (11.62 mg, 0.485 mmol) portion wise. The mixture was stirred for additional 2 hours. The mixture was neutralized with 1 Ν HC1 solution, and the result mixture was concentrated to ~2 mL. The mixture was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in water/CH ₃ CN) to afford the titled compound and Example 159. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 8.28 (s, 2H), 7.33 - 7.20 (m, 4H), 7.17 (dd, J = 9.2, 7.3 Hz, 1H), 7.09 (d, J = 8.3 Hz, 1H), 7.03 - 6.96 (m, 1H), 6.87 (dd, J = 11.9, 8.2 Hz, 2H), 3.83 (d, J = 6.8 Hz, 1H), 3.80 (d, J = 4.1 Hz, 3H), 3.33 - 3.24 (m, 2H), 3.22 (d, J = 11.4 Hz, 3H), 2.87 (t, J = 7.8 Hz, 2H), 2.69 (t, J = 9.0 Hz, 1H), 2.54 (dt, J = 27.4, 9.4 Hz, 3H), 2.35 (dt, J = 22.8, 6.9 Hz, 2H), 2.12 (t, J = 7.3 Hz, 1H), 1.81 (dd, J = 10.0, 5.3 Hz, 1H), 1.61 - 1.34 (m, 4H), 1.25 (p, J = 7.3 Hz, 1H), 1.04 (td, J = 9.6, 8.9, 5.2 Hz, 1H); LC-MS (ESI) m/z 454.2 (M+H) ⁺ , RT = 1.929 minutes

Example 159

5-{ [ira«5'-3-methoxy-l -(4-methoxyphenyl)cyclobutane-l -carbonyl](3^henylpropyl)amino}pentanoic acid

[001180] See Example 158 for details. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 8.35 (s, 2H), 7.31 - 7.12 (m, 5H), 7.06 (d, J = 8.2 Hz, 1H), 6.95 - 6.90 (m, 1H), 6.85 (d, J = 8.1 Hz, 2H), 3.86 (dt, J = 13.0, 6.7 Hz, 1H), 3.78 (d, J = 3.9 Hz, 3H), 3.31 (q, J = 6.6 Hz, 2H), 3.24 (d, J = 6.2 Hz, 3H), 3.08 - 2.93 (m, 2H), 2.87 (q, J = 9.0 Hz, 2H), 2.61 (t, J = 7.8 Hz, 1H), 2.43 - 2.28 (m, 2H), 2.21 (dt, J = 18.9, 7.4 Hz, 2H), 2.03 (t, J = 7.4 Hz, 1H), 1.85 (q, J = 7.8, 7.4 Hz, 1H), 1.60 (d, J = 5.8 Hz, 2H), 1.28 - 1.09 (m, 2H), 0.85 (ddt, J = 15.9, 11.6, 6.2 Hz, 1H); LC-MS (ESI) m/z 454.2 (M+H) ⁺ , RT = 1.913 minutes.

Example 160

5-[(2-methyl-4-oxo-3,4-dihydroquinazoline-8-carbonyl)(3-phen ylpropyl)arnino]pentanoic acid

[001181] A 4 mL scintillation vial was charged with 210 μL· of a 0.6 mM solution of 2-methyl-4- oxo-3,4-dihydroquinazoline-8-carboxylic acid in dimethylacetamide (25.7 mg, 1.2 equivalents, 0.13 mmol), 500 μL· of a solution of l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (HATU) in dimethylacetamide (43.9 mg, 1.1 equivalents, 0.12 mmol), 500 μL· of a solution of methyl 5-[(3-phenylpropyl)amino]pentanoate in dimethylacetamide (30.0 mg, 0.10 mmol, Example 70-Step 1), neat triethylamine (44.2 μΕ, 3 equivalents, 0.31 mmol), and a stir bar. This was capped with a white seal and microwave cap for an Anton Paar microwave reactor. The vial was placed in an Anton Paar Synthos 3000 parallel microwave optimizer and heated for 15 minutes at 120 °C. Upon completion, the mixture was filtered, and the filtrate was concentrated to dryness under reduced pressure. The residue was then dissolved in 1000 μL· of dioxane. 1000 μL· of a 1 M LiOH aqueous solution in 75% methanol was added. The mixture was then heated at 60 °C for 1 hour. The reacting mixture was then filtered once more and concentrated to dryness under reduced pressure. The residue was re -dissolved in dimethyl sulfoxide/methanol and purified using preparative-HPLC to give the titled compound (22.5 mg, 53.7%). H NMR (400 MHz, DMSO-<¾) δ ppm 8.03 (dd, J = 7.9, 1.5 Hz, 1H), 7.54 (dd, J = 7.3, 1.6 Hz, 1H), 7.42 (t, J = 7.6 Hz, 1H), 7.32 - 7.24 (m, 2H), 7.07 - 6.99 (m, 2H), 6.80 (dd, J = 7.7, 1.8 Hz, 1H), 3.54 - 3.47 (m, 1H), 2.97 (t, J = 7.0 Hz, 1H), 2.89 (t, J = 7.9 Hz, 1H), 2.74 (t, J = 7.9 Hz, 1H), 2.31 - 2.24 (m, 5H), 1.93 (q, J = 8.2, 7.8 Hz, 2H), 1.71 (q, J = 7.5, 6.8 Hz, 1H), 1.63 (dd, J = 6.6, 3.3 Hz, 2H), 1.39 (q, J = 8.6, 7.3 Hz, 1H), 1.19 (p, J = 7.4 Hz, 1H); MS (APCI ⁺ ) nt/z 422.0 (M+H) ⁺ .

Example 161

N- { 5 -[(methanesulfonyl)amino] -4-methyl-5 -oxopentyl } -3 ,5-dimethoxy-4-methyl-N-(3 - phenylpropyl)benzamide

[001182] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2- methylpentanoic acid (100 mg, 0.234 mmol, Example 54) and Ι,Γ-carbonyldiimidazole (45.5 mg, 0.281 mmol) in tetrahydrofuran (2 mL) was stirred at 50 °C for 60 minutes. Methanesulfonamide (26.7 mg, 0.281 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (0.056 mL, 0.374 mmol) were added, and the reaction mixture was stirred at 50 °C. The reaction mixture was diluted with 20 mL of ethyl acetate, washed with 20 mL each of 1 N HCl and saturated NaCl, dried with MgS0 ₄ and concentrated. Flash chromatography on silica gel (5-100% ethyl acetate/heptanes) gave the titled compound (15 mg, 13%). *H NMR (400 MHz, DMSO-<¾) δ ppm 1.13 (m, 3H), 1.53 (m, 3H) (m, 2H), 2.01 (s, 3H), 2.42 (m, 2H), 2.53 (t, / = 7.6 Hz, 2H), 3.15 (s, 3H), 3.29 (q, / = 7.0, 6.3 Hz, 4H), 3.76 (s, 6H), 6.49 (s, 2H), 7.16 (m, 5H), 11.07 (s, 1H); MS (DCI) nt/z 504 (M+H) ⁺ .

Example 162

N- { 5 -[(methanesulfonyl)amino] -4,4-dimethyl-5 -oxopentyl } -3 ,5-dimethoxy-4-methyl-N-(3 - phenylpropyl)benzamide

[001183] A mixture of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]-2,2 - dimethylpentanoic acid (90 mg, 0.204 mmol, Example 57) and l,l'-carbonyldiimidazole (39.7 mg, 0.245 mmol), in tetrahydrofuran (2 mL) was stirred at 50 °C for 60 minutes. Methanesulfonamide (29.1 mg, 0.306 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (0.049 mL, 0.326 mmol) were added, and the reaction mixture was stirred at 50 °C overnight. The reaction mixture was diluted with 20 mL of ethyl acetate, washed with 20 mL each of 1 N HCl and saturated NaCl, dried with MgS0 ₄ and concentrated. Flash chromatography on silica gel (100% ethyl acetate) gave the titled compound (30 mg, 90%). *H NMR (400 MHz, DMSO-<¾) δ ppm 1.09 (d, / = 1.4 Hz, 6H), 1.45 (d, / = 3.2 Hz, 4H), 1.86 (p, / = 7.6 Hz, 2H), 2.01 (s, 3H), 2.54 (t, / = 7.7 Hz, 2H), 3.09 (d, / = 1.4 Hz, 3H), 3.26 (t, / = 7 Hz, 2H), 3.32 (t, / = 7 Hz, 2H), 3.76 (d, / = 1.4 Hz, 6H), 6.50 (s, 2H), 7.04 - 7.32 (m, 5H), 10.61 (s, 1H); MS (DCI) m/z 519 (M+H) ⁺ . Example 163

5-[(2,6-dimethoxypyrimidine-4-carbonyl)(3-phenylpropyl)amino ]pentanoic acid

[001184] Step 1 : 2,6-dimethoxypyrimidine-4-carbonyl chloride

[001185] Oxalyl chloride (0.092 mL, 1.051 mmol) was added dropwise to a stirred mixture of 2,6- dimethoxypyrimidine-4-carboxylic acid (168 mg, 0.910 mmol) and catalytic N,N-dimethylformamide (5.42 μL·, 0.070 mmol) in dichloromethane (14 mL). After stirring for 2.3 hours, volatiles were removed under reduced pressure to give a white solid. The solid was treated with i-butyl methyl ether. Any insolubles were removed by filtration and the filtrate was concentrated under reduced pressure (bath temperature: 25 °C) to give the titled compound that was dissolved in CH ₂ C1 ₂ (10 mL).

[001186] Step 2: methyl 5-[(2,6-dimethoxypyrimidine-4-carbonyl)(3- phenylpropyl) amino] pentanoate

[001187] The stirred solution above was treated with a suspension of methyl 5-[(3- phenylpropyl) amino] pentanoate-hydrogen chloride (200 mg, 0.7 mmol, Example 149-Step 2) in CH ₂ C1 ₂ (20 mL). Next, triethylamine (0.293 mL, 2.100 mmol) was added. Finally a solution of 4- (dimethylamino)pyridine (42.8 mg, 0.350 mmol) in CH ₂ C1 ₂ (3 mL) was added. The reaction mixture was then stirred at ambient temperature for 16.5 hours. Volatiles were removed under reduced pressure to give a residue that was purified by flash chromatography (100% CH ₂ C1 ₂ to 60:40

CH ₂ Cl ₂ /ethyl acetate) to give the titled compound (226 mg 78% yield). H NMR (CDC1 ₃ ) δ ppm 7.32-7.14 (m, 4H), 7.06-7.01 (m, 1H), 6.50 (d, J = 22.6 Hz, 1H), 4.01 3.93 (m, 6H), 3.66 (d, J = 10.7 Hz, 3H), 3.48 (dt, J = 13.6, 6.9 Hz, 2H), 3.32-3.24 (m, 2H), 2.70 (t, J = 7.9 Hz, 1H), 2.50 (t, J = 7.5 Hz, 1H), 2.40-2.33 (m, 1H), 2.23 (t, J = 7.2 Hz, 1H), 2.05-1.88 (m, 2H), 1.70-1.65 (m, 2H), 1.54 (ddt, J = 49.6, 15.1, 7.2 Hz, 2H); MS (ESI+) m/z 416 (M+H) ⁺ .

[001188] Step 3: 5-[(2,6-dimethoxypyrimidine-4-carbonyl)(3-phenylpropyl)arnin o]pentanoic acid

[001189] A solution of methyl 5-[(2,6-dimethoxypyrimidine-4-carbonyl)(3- phenylpropyl) amino] pentanoate (210 mg, 0.505 mmol, Step 2) in tetrahydrofuran (4.2 mL) and methanol (0.85 mL) was stirred at ambient temperature. Lithium hydroxide, 0.5 M aqueous (3.033 mL, 1.517 mmol) was added, and the reaction mixture was stirred at ambient temperature for 27 hours. The reaction mixture was brought to pH = 4 with aqueous citric acid, diluted with brine and extracted with ethyl acetate. The organic layer was dried (MgS0 ₄ ) and filtered. The filtrate was concentrated under reduced pressure to give a residue. Flash chromatography on silica gel (100% CH ₂ C1 ₂ to 97:3 CH ₂ C1 ₂ /CH ₃ 0H) gave the titled compound (151 mg, 74.4% yield). *H NMR (CDC1 ₃ ) δ ppm 7.31-7.26 (m, 1H), 7.25-7.14 (m, 3H), 7.04 (dd, J = 6.9, 1.7 Hz, 1H), 6.50 (d, J = 29.6 Hz, 1H), 3.97 (d, J = 21.5 Hz, 6H), 3.52-3.46 (m, 2H), 3.28 (ddd, J = 9.4, 6.6, 1.9 Hz, 2H), 2.72-2.67 (m, 1H), 2.50 (t, J = 7.5 Hz, 1H), 2.44-2.39 (m, 1H), 2.27 (t, J = 7.3 Hz, 1H), 2.03-1.89 (m, 2H), 1.69 (p, J = 3.7 Hz, 2H), 1.66-1.59 (m, 1H), 1.49 (p, J = 7.4 Hz, 1H); MS (ESI+) m/z 402 (M+H) ⁺ , MS (ESI-) m/z 400 (M-H) . Example 164

5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino]hexanoic acid

[001190] Step 1 : methyl 5-[(3-phenylpropyl)amino]hexanoate

[001191] 3-Phenylpropan-l -amine (200 mg, 1.479 mmol) and potassium carbonate (245 mg, 1.775 mmol) were dissolved in dry CH ₃ CN (6 mL) at room temperature. Methyl 5-bromohexanoate (340 mg, 1.627 mmol) dissolved in dry CH ₃ CN was added slowly to the mixture, and then the reaction was stirred at reflux for 3 hours. Then the mixture was cooled down and filtered. The filtrate was concentrated to give the titled compound.

[001192] Step 2: methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]hexa noate

[001193] 3,5-Dimethoxy-4-methylbenzoic acid (281 mg, 1.430 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (652 mg, 1.716 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (554 mg, 4.29 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 164-Step 1 (377 mg, 1.43 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column

chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (233 mg, 0.528 mmol, 36.9% yield). LC-MS (ESI) m/z 442.2 (M+H) ⁺ .

[001194] Step 3: 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]hexa noic acid

[001195] Example 164-Step 2 (45 mg, 0.102 mmol) was dissolved in tetrahydrofuran (2 mL) and lithium hydroxide (14.64 mg, 0.611 mmol) in water (2 mL) was added. The mixture was stirred for 12 hours at room temperature. The mixture was poured into water, the pH was adjusted to 5, and the acidic mixture was extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H in water/CH ₃ CN) to give the titled compound (20 mg, 0.047 mmol, 45.9% yield). H NMR (400 MHz, DMSO-<¾) δ ppm 12.02 (s, 2H), 7.44 - 7.02 (m, 5H), 6.46 (s, 2H), 3.60 (s, 1H), 3.08 (s, 1H), 2.62 (t, J = 8.2 Hz, 2H), 2.06 (q, J = 6.0, 5.2 Hz, 2H), 1.98 (s, 5H), 1.59 - 0.88 (m, 8H); LC- MS (ESI) m/z 428.2 (M+H) ⁺ .

Example 165

5-[(4-cyclopropyl-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino ]-2-hydroxypentanoic acid

[001196] Step 1 : methyl 2-(acetyloxy)-5-[(4-cyclopropyl-3,5-dimethoxybenzoyl)(3- phenylpropyl) amino] pentanoate [001197] To a solution of 4-cyclopropyl-3,5-dimethoxybenzoic acid (164 mg, 0.740 mmol) and 1- [bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid hexafluorophosphate (310 mg, 0.814 mmol, HATU) in N,N-dimethylformamide (3 mL) was added triethylamine (0.113 mL 0.814 mmol). The resultant mixture was stirred at room temperature for 10 minutes. Then a solution of Example 151-Step 2 (227 mg, 0.740 mmol) in N,N-dimethylformamide (1.0 mL) was added to the reaction system. The mixture was stirred at room temperature for 40 minutes. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-30%) to give the titled compound (128 mg, 0.228 mmol, 30.8% yield). LC-MS (ESI) m/z 512.2 (M+H) ⁺ , RT = 2.149 minutes.

[001198] Step 2: 5-[(4-cyclopropyl-3,5-dimethoxybenzoyl)(3-phenylpropyl)amino ]-2- hydroxypentanoic acid

[001199] To a solution of Example 165-Step 1 (128 mg, 0.250 mmol) in tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (2.502 mL, 2.502 mmol). The mixture was stirred at room temperature for 2 hours. The mixture was concentrated, and the aqueous residue was washed with ethyl ether twice and then acidified with 1 N HC1 to pH=2-3. The acidic aqueous mixture was extracted with ethyl acetate 3 times. The combined organic layers were dried and concentrated. The residue was purified by preparative HPLC (0.1 % NH ₃ in H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (65 mg, 0.143 mmol, 57.0% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.32 - 7.01 (m, 5H), 6.73 (s, 1H), 6.44 (s, 2H), 3.71 (s, 6H), 3.46 (s, 1H), 3.36 (s, 2H), 3.13 (s, 2H), 2.60 (s, 1H), 2.40 (s, 1H), 1.84 (tt, J = 8.8, 5.7 Hz, 3H), 1.57 (s, 3H), 1.40 (s, 1H), 0.99 - 0.89 (m, 2H), 0.74 (dt, J = 8.5, 3.0 Hz, 2H); LC-MS (ESI) m/z 456.2 (M+H) ⁺ , RT = 1.912 minutes.

Example 166

3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)-N-[4-(lH-tetrazol- 5-yl)butyl]benzamide

[001200] Step 1 : N-(5-amino-5-oxopentyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpr opyl)benzamide

[001201] A solution of 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]pent anoic acid (100 mg, 0.242 mmol, Example 4) in tetrahydrofuran (5 mL) was treated with ((3H- [ 1 ,2,3]triazolo[4,5-¾]pyridin-3-yl)oxy)tri(pyrrolidin- 1 -yl)phosphonium hexafluorophosphate(V) (126 mg, 0.242 mmol) followed by N-ethyl-N-isopropylpropan-2-amine (31.3 mg, 0.242 mmol), and the reaction mixture was stirred for 1 hour. ΝΗ ₄ ΟΗ (0.49 mL, 3.76 mmol) was added, and the mixture was stirred for 18 hours. The mixture was concentrated, and the residue was partitioned between ethyl acetate and 1 Ν HQ. The organic fraction was washed with 1 Ν NaOH and brine, dried (MgS0 ₄ ) and concentrated to the titled compound that was used directly in the next step.

[001202] Step 2: N-(4-cyanobutyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)be nzamide [001203] N-(5-amino-5-oxopentyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpr opyl)benzamide (430 mg, 1.042 mmol, Step 1) in dioxane/pyridine (5 mL/0.5 mL) was cooled to 0 °C and treated with trifluoromethanesulfonic anhydride (0.15 mL, 1.04 mmol). The reaction mixture was warmed to room temperature and stirred for 4 hours. The mixture was partitioned between ethyl acetate and brine. The organic layer was washed with water (2x30 mL), dried (MgS0 ₄ ) and concentrated to give the titled compound (410 mg) that was used directly in the next step.

[001204] Step 3: 3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)-N-[4-(lH-tetrazol- 5- yl) butyl] benzamide

[001205] A solution of N-(4-cyanobutyl)-3,5-dimethoxy-4-methyl-N-(3-phenylpropyl)be nzamide (300 mg, 0.760 mmol) in N,N-dimethylformamide was treated with sodium azide (222 mg, 3.42 mmol) and ammonium chloride (61.0 mg, 1.141 mmol) and then heated to 105 °C for 72 hours. The reaction mixture was cooled to room temperature and poured into water. The aqueous mixture was acidified with HC1, and extracted with ethyl acetate. The organic fraction was washed with brine (3x25 mL), dried (MgS0 ₄ ) and concentrated. Flash chromatography on silica gel (100% ethyl acetate) gave the titled compound (74 mg, 22%). Ή NMR (400 MHz, DMSO-<¾) δ ppm 1.49 - 1.77 (m, 4H), 1.85 (t, / = 7.6 Hz, 2H), 2.01 (s, 3H), 2.52 (t, / = 7.6 Hz, 3H), 2.83 (t, / = 7.1 Hz, 2H), 3.26 - 3.38 (m, 4H), 3.74 (d, / = 0.9 Hz, 6H), 6.49 (s, 2H), 7.11 (t, / = 7.2 Hz, 3H), 7.20 (dd, / = 8.3, 6.5 Hz, 2H); MS (DCI) m/z 438 (M+H) ⁺ .

Example 167

5-[(5-chloro-2-methylpyrimidine-4-carbonyl)(3-phenylpropyl)a rnino]pentanoic acid

[001206] A 4 mL Wheaton scintillation vial was charged with 280 μL· of a 0.6 mM solution of 5- chloro-2-methylpyrimidine-4-carboxylic acid in N,N-dimethylacetamide (30.0 mg, 1.2 equivalents, 0.2 mmol), a 500 μL· solution of l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate in N,N-dimethylacetamide (58.5 mg, 1.1 equivalents, 0.15 mmol, HATU), a 500 μL· solution of methyl 5-[(3-phenylpropyl)amino]pentanoate hydrochloride in N,N-dimethylacetamide (40.0 mg, 0.14 mmol, Example 149-Step 2), neat triethylamine (58.9 μL·, 3 equivalents, 0.42 mmol), and a stir bar. This was capped with a white seal and microwave cap for an Anton Paar microwave reactor. The vial was heated in an Anton Paar Synthos 3000 parallel microwave optimizer for 15 minutes at 120 °C. Upon completion, the reaction mixture was filtered, and the filtrate was concentrated to dryness under reduced pressure. The residue was then dissolved in 1000 μL· of dioxane. To this, 1000 μΕ of a 1 M LiOH aqueous solution in 75% CH ₃ OH was added. The mixture was then heated at 60 °C for 1 hour. The reaction mixture was then filtered once more and concentrated under reduced pressure. The residue was re -dissolved in dimethyl

sulfoxide/methanol and purified using preparative-HPLC to give the titled compound (42.3 mg, 73.6%). *H NMR (400 MHz, DMSO-<¾) δ ppm 8.72 (d, J = 35.5 Hz, 1H), 7.31 - 7.08 (m, 4H), 6.97 (d, J = 7.4 Hz, 1H), 3.52 - 3.41 (m, 2H), 3.09 - 3.05 (m, 1H), 2.66 (t, J = 7.6 Hz, 1H), 2.59 (d, J = 23.0 Hz, 3H), 2.43 (t, J = 7.3 Hz, 1H), 2.26 (t, J = 6.9 Hz, 1H), 2.06 (t, J = 7.2 Hz, 1H), 1.94 (p, J = 7.5, 6.9 Hz, 1H), 1.80 (dt, J = 13.0, 6.2 Hz, 2H), 1.70 - 1.56 (m, 3H), 1.50 (q, J = 8.2, 7.8 Hz, 1H), 1.35 (p, J = 6.8 Hz, 1H); MS (APCI ⁺ ) m/z 390.0 (M+H) ⁺ .

Example 168

5-[(6-fluoro-2-oxo-l ,2,3,4 etrahydroquinoline-4-carbonyl)(3^henylpropyl)amino]pentanoic acid

[001207] A 4 mL Wheaton scintillation vial was charged with 280 μL· of a 0.6 mM solution of 6- fluoro-2-oxo-l ,2,3,4-tetrahydroquinoline-4-carboxylic acid in N,N-dimethylacetamide (35.13 mg, 1.2 equivalents, 0.2 mmol), a 500 μL· solution of l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate in N,N-dimethylacetamide (58.5 mg, 1.1 equivalents, 0.15 mmol, HATU), a 500 μL· solution of methyl 5-[(3-phenylpropyl)amino]pentanoate hydrochloride in N,N-dimethylacetamide (40.0 mg, 0.14 mmol, Example 149-Step 2), neat triethylamine (58.9 μΕ, 3 equivalents, 0.42 mmol), and a stir bar. This was capped with a white seal and microwave cap for an Anton Paar microwave reactor. The vial was heated in an Anton Paar Synthos 3000 parallel microwave optimizer for 15 minutes at 120 °C. Upon completion, the reaction mixture was filtered, and the filtrate was concentrated to dryness under reduced pressure. The residue was then dissolved in 1000 μΕ of dioxane. To this, 1000 μΕ of a 1 M LiOH aqueous solution in 75% CH ₃ OH was added. The mixture was then heated at 60 °C for 1 hour. The reaction mixture was then filtered once more and concentrated under reduced pressure. The residue was re -dissolved in dimethyl

sulfoxide/methanol and purified using preparative-HPLC to give the titled compound (46.3 mg, 77.7%). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.27 - 7.21 (m, 2H), 7.19 - 7.10 (m, 3H), 6.94 (td, J = 8.6, 2.7 Hz, 1H), 6.89 (dd, J = 8.7, 5.2 Hz, 1H), 6.71 (d, J = 9.8 Hz, 1H), 4.25 - 4.17 (m, 1H), 3.43 (dt, J = 14.9, 8.0 Hz, 2H), 3.31 (dt, J = 14.5, 7.4 Hz, 2H), 2.62 - 2.51 (m, 4H), 2.21 (t, J = 6.9 Hz, 2H), 1.91 - 1.76 (m, 2H), 1.61 - 1.48 (m, 4H); MS (APCI ⁺ ) m/z 427.1 (M+H) ⁺ .

Example 169

5-[(2-methyl-l -oxo-1 ,2-dihydroisoquinoline-4-carbonyl)(3-phenylpropyl)amino]pent anoic acid

[001208] A 4 mL Wheaton scintillation vial was charged with 280 μL· of a 0.6 mM solution of 2- methyl-l-oxo-l ,2-dihydroisoquinoline-4-carboxylic acid in N,N-dimethylacetamide (34.1 mg, 1.2 equivalents, 0.2 mmol), a 500 μL· solution of l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate in N,N-dimethylacetamide (58.5 mg, 1.1 equivalents, 0.15 mmol, HATU), a 500 μL· solution of methyl 5-[(3-phenylpropyl)amino]pentanoate hydrochloride in N,N-dimethylacetamide (40.0 mg, 0.14 mmol, Example 149-Step 2), neat triethylamine (58.9 μL·, 3 equivalents, 0.42 mmol), and a stir bar. This was capped with a white seal and microwave cap for an Anton Paar microwave reactor. The vial was heated in an Anton Paar Synthos 3000 parallel microwave optimizer for 15 minutes at 120 °C. Upon completion, the reaction mixture was filtered, and the filtrate was concentrated to dryness under reduced pressure. The residue was then dissolved in 1000 μL· of dioxane. To this, 1000 μΕ of a 1 M LiOH aqueous solution in 75% CH ₃ OH was added. The mixture was then heated at 60 °C for 1 hour. The reaction mixture was then filtered once more and concentrated under reduced pressure. The residue was re -dissolved in dimethyl

sulfoxide/methanol and purified using preparative-HPLC to give the titled compound (24.8 mg, 51.1 %). *H NMR (400 MHz, DMSO-<¾) δ ppm 8.26 (dd, J = 8.1 , 1.4 Hz, 1H), 7.67 (ddd, J = 8.4, 7.2, 1.5 Hz, 1H), 7.51 (ddd, J = 8.2, 7.2, 1.2 Hz, 1H), 7.41 (d, J = 8.1 Hz, 1H), 7.32 (s, 1H), 7.19 - 7.13 (m, 2H), 7.11 - 7.06 (m, 1H), 7.02 (d, J = 7.4 Hz, 2H), 3.33 (dt, J = 18.2, 7.3 Hz, 4H), 2.51 (d, J = 7.5 Hz, 2H), 2.16 (t, J = 7.1 Hz, 2H), 1.85 (p, J = 7.5 Hz, 2H), 1.59 (p, J = 7.1 Hz, 2H), 1.48 (p, J = 7.2 Hz, 2H); MS (APCI ⁺ ) m/z 421.1 (M+H) ⁺ .

Example 170

5-[(7-fluoro-2-oxo-l ,2,3,4-tetrahydroquinoline-4-carbonyl)(3-phenylpropyl)amino] pentanoic acid

[001209] A 4 mL Wheaton scintillation vial was charged with 280 μL· of a 0.6 mM solution of 7- fluoro-2-oxo-l ,2,3,4-tetrahydroquinoline-4-carboxylic acid in N,N-dimethylacetamide (35.1 mg, 1.2 equivalents, 0.2 mmol), a 500 μL· solution of l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate in N,N-dimethylacetamide (58.5 mg, 1.1 equivalents, 0.15 mmol, HATU), a 500 μL· solution of methyl 5-[(3-phenylpropyl)amino]pentanoate hydrochloride in N,N-dimethylacetamide (40.0 mg, 0.14 mmol, Example 149-Step 2), neat triethylamine (58.9 μΕ, 3 equivalents, 0.42 mmol), and a stir bar. This was capped with a white seal and microwave cap for an Anton Paar microwave reactor. The vial was heated in an Anton Paar Synthos 3000 parallel microwave optimizer for 15 minutes at 120 °C. Upon completion, the reaction mixture was filtered, and the filtrate was concentrated to dryness under reduced pressure. The residue was then dissolved in 1000 μΕ of dioxane. To this, 1000 μΕ of a 1 M LiOH aqueous solution in 75% CH ₃ OH was added. The mixture was then heated at 60 °C for 1 hour. The reaction mixture was then filtered once more and concentrated under reduced pressure. The residue was re -dissolved in dimethyl

sulfoxide/methanol and purified using preparative-HPLC to give the titled compound (13.8 mg, 27.2%). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.23 (t, J = 7.5 Hz, 2H), 7.14 (dd, J = 15.6, 7.6 Hz, 3H), 6.94 (t, J = 7.2 Hz, 1H), 6.70 - 6.61 (m, 2H), 4.17 (s, 1H), 3.42 (dt, J = 14.8, 7.3 Hz, 2H), 3.30 (p, J = 7.1 Hz, 2H), 2.56 (dt, J = 12.3, 6.7 Hz, 4H), 2.21 (t, J = 6.7 Hz, 2H), 1.91 - 1.76 (m, 2H), 1.60 - 1.45 (m, 4H); MS (APCI ⁺ ) m/z 427.0 (M+H) ⁺ . Example 171

5-[(2-acetamidopyridine-4-carbonyl)(3-phenylpropyl)amino]pen tanoic acid

[001210] A 4 mL Wheaton scintillation vial was charged with 280 μL· of a 0.6 mM solution of 2- acetamidoisonicotinic acid in N,N-dimethylacetamide (30.3 mg, 1.2 equivalents, 0.2 mmol), a 500 μL· solution of l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5-¾]pyridinium 3-oxid

hexafluorophosphate in N,N-dimethylacetamide (58.5 mg, 1.1 equivalents, 0.15 mmol, HATU), a 500 μL· solution of methyl 5-[(3-phenylpropyl)amino]pentanoate hydrochloride in N,N-dimethylacetamide (40.0 mg, 0.14 mmol, Example 149-Step 2), neat triethylamine (58.9 μΕ, 3 equivalents, 0.42 mmol), and a stir bar. This was capped with a white seal and microwave cap for an Anton Paar microwave reactor. The vial was heated in an Anton Paar Synthos 3000 parallel microwave optimizer for 15 minutes at 120 °C. Upon completion, the reaction mixture was filtered, and the filtrate was concentrated to dryness under reduced pressure. The residue was then dissolved in 1000 μΕ of dioxane. To this, 1000 μΕ of a 1 M LiOH aqueous solution in 75% CH ₃ OH was added. The mixture was then heated at 60 °C for 1 hour. The reaction mixture was then filtered once more and concentrated under reduced pressure. The residue was re-dissolved in dimethyl sulfoxide/methanol and purified using preparative-HPLC to give the titled compound (11.9 mg, 19.1 %). 'H NMR (400 MHz, DMSO-<¾) δ ppm 8.27 (d, J = 5.0 Hz, 1H), 7.88 (d, J = 1.2 Hz, 1H), 7.20 (t, J = 7.5 Hz, 2H), 7.11 (dd, J = 9.0, 6.6 Hz, 3H), 6.92 (dd, J = 5.0, 1.4 Hz, 1H), 3.28 (s, 4H), 2.52 (d, J = 7.5 Hz, 1H), 2.16 (t, J = 7.2 Hz, 2H), 2.10 (s, 3H), 1.92 - 1.79 (m, 2H), 1.55 (p, J = 7.5 Hz, 2H), 1.46 (dd, J = 15.2, 6.9 Hz, 3H); MS (APCI ⁺ ) m/z 398.0 (M+H) ⁺ .

Example 172

5-[(3,6-dimethyl[l ,2]oxazolo[5,4-¾]pyridine-4-carbonyl)(3-phenylpropyl)amino] pentanoic acid

[001211] A 4 mL Wheaton scintillation vial was charged with 280 μL· of a 0.6 mM solution of 3,6- dimethylisoxazolo[5,4-Z?]pyridine-4-carboxylic acid in N,N-dimethylacetamide (32.7 mg, 1.2 equivalents, 0.2 mmol), a 500 μL· solution of l-[bis(dimethylamino)methylene]-lH-l ,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate in N,N-dimethylacetamide (58.5 mg, 1.1 equivalents, 0.15 mmol, HATU), a 500 μL· solution of methyl 5-[(3-phenylpropyl)amino]pentanoate hydrochloride in N,N-dimethylacetamide (40.0 mg, 0.14 mmol, Example 149-Step 2), neat triethylamine (58.9 μL·, 3 equivalents, 0.42 mmol), and a stir bar. This was capped with a white seal and microwave cap for an Anton Paar microwave reactor. The vial was heated in an Anton Paar Synthos 3000 parallel microwave optimizer for 15 minutes at 120 °C. Upon completion, the reaction mixture was filtered, and the filtrate was concentrated to dryness under reduced pressure. The residue was then dissolved in 1000 μL· of dioxane. To this, 1000 μΕ of a 1 M LiOH aqueous solution in 75% CH ₃ OH was added. The mixture was then heated at 60 °C for 1 hour. The reaction mixture was then filtered once more and concentrated under reduced pressure. The residue was re -dissolved in dimethyl sulfoxide/methanol and purified using preparative-HPLC to give the titled compound (9.8 mg, 20.2%). *H NMR (400 MHz, DMSO-<¾) δ ppm 7.36 - 7.23 (m, 2H), 7.22 - 7.16 (m, 1H), 7.14 - 7.05 (m, 2H), 6.87 (d, J = 4.5 Hz, 1H), 3.56 - 3.48 (m, 3H), 3.17 - 3.05 (m, 2H), 2.75 - 2.66 (m, 1H), 2.62 (d, J = 22.0 Hz, 3H), 2.41 - 2.35 (m, 4H), 2.34 - 2.26 (m, 1H), 2.05 - 1.95 (m, 1H), 1.83 - 1.58 (m, 4H), 1.50 - 1.39 (m, 1H), 1.34 - 1.23 (m, 1H); MS (APCI ⁺ ) m/z 410.1 (M+H) ⁺ .

Example 173

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(furan-2-yl)propyl]arni no}pentanoic acid

[001212] Step 1 : methyl 5-{ [3-(furan-2-yl)propyl]amino}pentanoate

[001213] A mixture of 3-(furan-2-yl)propan-l-amine (100 mg, 0.799 mmol), methyl 5- bromopentanoate (156 mg, 0.799 mmol) and potassium carbonate (132 mg, 0.959 mmol) in CH ₃ CN (4 mL) was stirred at reflux for 1 hour. The mixture was cooled down and filtered. The filtrate was concentrated to give the titled compound. LC-MS (ESI) m/z 240.2 (M+H) ⁺ , RT = 1.343 minutes.

[001214] Step 2: methyl 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(furan-2- yl)propyl] amino } pentanoate

[001215] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (157 mg, 0.799 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (334 mg, 0.879 mmol, HATU) in N,N-dimethylformamide (4 mL) was added triethylamine (0.122 mL 0.879 mmol). The resultant mixture was stirred at room temperature for 10 minutes. A solution of Example 173-Step 1 (191 mg, 0.799 mmol) in N,N-dimethylformamide (1.0 mL) was added to the reaction system. The mixture was stirred at room temperature for 40 minutes. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-40%) to give the titled compound (108 mg, 0.259 mmol, 32.4% yield). LC-MS (ESI) m/z 418.2 (M+H) ⁺ , RT = 2.051 minutes.

[001216] Step 3: 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(furan-2-yl)propyl]amin o}pentanoic acid

[001217] To a solution of Example 173-Step 2 (108 mg, 0.259 mmol) in tetrahydrofuran (1 mL) was added 1 N lithium hydroxide (1.552 mL 1.552 mmol). The mixture was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure, and the aqueous residue was washed with ethyl ether twice and then acidified with 1 N HCl to pH=2-3. The mixture was extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine once, dried and concentrated. The residue was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in water/CH ₃ CN) and lyophilized to give the titled compound (79 mg, 0.196 mmol, 76% yield). 'H NMR (400 MHz, DMSO-<¾) δ ppm 12.10 (s, 1H), 7.43 (d, J = 54.6 Hz, 1H), 6.50 (s, 2H), 6.39 - 6.21 (m, 1H), 6.03 (d, J = 99.7 Hz, 1H), 3.75 (s, 6H), 3.38 (s, 2H), 3.15 (s, 2H), 2.66 (s, 1H), 2.43 (s, 1H), 2.25 (s, 1H), 2.08 (s, 1H), 1.98 (s, 3H), 1.84 (d, J = 30.1 Hz, 2H), 1.52 (s, 3H), 1.29 (s, 1H); LC-MS (ESI) m/z 404.2 (M+H) ⁺ , RT = 1.882 minutes.

Example 174

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2-yl)pro pyl]amino}-2-hydroxy-2- methylpentanoic acid

[001218] Step 1 : methyl 2-(acetyloxy)-2-methyl-5-{ [3-(5-methylfuran-2- yl)propyl] amino } pentanoate

[001219] A mixture of 3-(5-methylfuran-2-yl)propan-l-amine (100 mg, 0.718 mmol) and Example 155-Step 1 (226 mg, 0.718 mmol) in CH ₃ CN (3 mL) was stirred at reflux for 50 minutes. The solution was cooled down and concentrated to give the titled compound. LC-MS (ESI) m/z 326.2 (M+H) ⁺ , RT = 1.555 minutes.

[001220] Step 2: methyl 2-(acetyloxy)-5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methyl furan-2- yl)propyl] amino } -2-methylpentanoate

[001221] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (141 mg, 0.718 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (300 mg, 0.790 mmol, HATU) in N,N-dimethylformamide (3 mL) was added triethylamine (0.110 mL 0.790 mmol). The resultant mixture was stirred at room temperature for 10 minutes. A solution of Example 174-Step 1 (234 mg, 0.718 mmol) in N,N-dimethylformamide (1.0 mL) was added to the reaction system. The mixture was stirred at room temperature for 40 minutes. It was diluted with water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine 3 times, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-40%) to give the titled compound (146 mg, 0.217 mmol, 30.3% yield). LC-MS (ESI) m/z 504.2 (M+H) ⁺ , RT = 2.131 minutes.

[001222] Step 3: 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2-yl)pro pyl]amino}-2- hydroxy-2-methylpentanoic acid

[001223] To a solution of Example 174-Step 2 (146 mg, 0.290 mmol) in tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (1.740 mL 1.740 mmol). The mixture was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure, and the aqueous residue was washed with ethyl ether twice and then acidified with 1 N HC1 to pH=2-3. The acidic aqueous mixture was extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine once, dried and concentrated. The residue was purified by preparative HPLC (0.1 % NH ₃ in H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (37 mg, 0.083 mmol, 28.5% yield). Ή NMR (400 MHz, DMSO-<¾) δ ppm 7.18 (s, 1H), 6.48 (s, 2H), 5.96 (d, J = 30.2 Hz, 1H), 5.77 (d, J = 20.7 Hz, 1H), 3.76 (s, 6H), 3.32 (s, 2H), 3.12 (d, J = 25.3 Hz, 2H), 2.58 (s, 1H), 2.36 (s, 1H), 2.14 (d, J = 42.1 Hz, 3H), 1.98 (s, 3H), 1.80 (d, J = 33.2 Hz, 2H), 1.61 (s, 2H), 1.38 (d, J = 16.4 Hz, 2H), 1.12 (d, J = 35.0 Hz, 3H); LC-MS (ESI) nt/z 448.2 (M+H) ⁺ , RT = 1.893 minutes.

Example 175

5-{(2,4-difluoro-3,5-dimethoxybenzoyl)[3-(5-methylfuran-2-yl )propyl]amino}pentanoic acid

[001224] Step 1 : methyl 5-{(2,4-difluoro-3,5-dimethoxybenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } pentanoate

[001225] 2,4-Difluoro-3,5-dimethoxybenzoic acid (51.7 mg, 0.237 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (108 mg, 0.284 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (92 mg, 0.711 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 133-Step 1 (60 mg, 0.237 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (100 mg, 0.221 mmol, 93% yield). LC-MS (ESI) nt/z 454.2 (M+H) ⁺ .

[001226] Step 2: 5-{(2,4-difluoro-3,5-dimethoxybenzoyl)[3-(5-methylfuran-2- yl)propyl] amino jpentanoic acid

[001227] The material of Example 175-Step 1 (100 mg, 0.221 mmol) was dissolved in

tetrahydrofuran (2 mL) and lithium hydroxide (31.7 mg, 1.323 mmol) solution (2 mL) was added. The mixture was stirred for 2 hours at room temperature. The mixture was poured into water, the pH was adjusted to 3, and the mixture was extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1% CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) to give the titled compound (65 mg, 0.148 mmol, 67.1% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 6.80 (ddd, J = 8.9, 5.7, 3.4 Hz, 1H), 5.76 (dd, J = 26.0, 2.9 Hz, 2H), 3.91 (d, J = 14.0 Hz, 3H), 3.81 (d, J = 10.0 Hz, 3H), 3.10 (t, J = 6.9 Hz, 2H), 2.57 (t, J = 7.7 Hz, 1H), 2.38 (t, J = 7.0 Hz, 1H), 2.25 (t, J = 6.9 Hz, 1H), 2.20 (s, 1H), 2.08 (d, J = 13.1 Hz, 2H), 1.85 (p, J = 7.6 Hz, 1H), 1.69 (t, J = 7.7 Hz, 1H), 1.54 (ddd, J = 17.6, 14.2, 7.7 Hz, 2H), 1.42 (q, J = 7.6 Hz, 1H), 1.29 (p, J = 7.4 Hz, 1H); LC-MS (ESI) nt/z 440.2 (M+H) ⁺ .

Example 176

5-{(3,5-diethoxybenzoyl)[3-(5-methylfuran-2-yl)propyl]amino} pentanoic acid

[001228] Step 1 : methyl 5-{(3,5-diethoxybenzoyl)[3-(5-methylfuran-2-yl)propyl]amino} pentanoate [001229] 3,5-Diethoxybenzoic acid (49.8 mg, 0.237 mmol) and l-[bis(dimethylamino)methylene]- lH-l,2,3-triazolo[4,5- ?]pyridinium 3-oxid hexafluorophosphate (108 mg, 0.284 mmol, HATU) was dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N- diisopropylethylamine (92 mg, 0.711 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 133-Step 1 (60 mg, 0.237 mmol) was added, and the solution was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (80 mg, 0.180 mmol, 76% yield). LC-MS (ESI) nt/z 446.2 (M+H) ⁺ .

[001230] Step 2: 5-{(3,5-diethoxybenzoyl)[3-(5-methylfuran-2-yl)propyl]amino} pentanoic acid

[001231] Example 176-Step 1 (96 mg, 0.215 mmol) was dissolved in tetrahydrofuran (2 mL) and lithium hydroxide (31.0 mg, 1.293 mmol) solution (2 mL) was added. The mixture was stirred for 2 hours at room temperature. The mixture was poured into water, the pH was adjusted to 3, and the mixture was extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) to give the titled compound (72 mg, 0.167 mmol, 77% yield). H NMR (400 MHz, DMSO-i¾) δ ppm 11.99 (s, 1H), 6.41 (d, J = 43.8 Hz, 3H), 3.99 (d, J = 7.4 Hz, 3H), 3.36 (s, 2H), 3.14 (s, 2H), 2.57 (s, 1H), 2.35 (s, 1H), 2.30 - 1.99 (m, 4H), 1.78 (d, J = 45.9 Hz, 2H), 1.48 (d, J = 32.6 Hz, 3H), 1.29 (t, J = 6.9 Hz, 5H); LC-MS (ESI) m/z 432.2 (M+H) ⁺ .

Example 177

5-{ [3,5-dimethoxy-4-(trifluoromethyl)benzoyl][3-(5-methylfuran- 2-yl)propyl]amino}pentanoic acid

[001232] Step 1 : methyl 5-{ [3,5-dimethoxy-4-(trifluoromethyl)benzoyl][3-(5-methylfuran- 2- yl)propyl] amino } pentanoate

[001233] 3,5-Dimethoxy-4-(trifluoromethyl)benzoic acid (59.3 mg, 0.237 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (108 mg, 0.284 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (92 mg, 0.711 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 133-Step 1 (60 mg, 0.237 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column

chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (98 mg, 0.202 mmol, 85% yield). [001234] Step 2: 5-{ [3,5-dimethoxy-4-(trifluoromethyl)benzoyl][3-(5-methylfuran- 2- yl)propyl] amino Ipentanoic acid

[001235] Example 177-Step 1 (96 mg, 0.198 mmol) was dissolved in tetrahydrofuran (2 mL) and lithium hydroxide (28.4 mg, 1.186 mmol) solution (2 mL) was added. The mixture was stirred for 2 hours at room temperature. The mixture was poured into water, the pH was adjusted to 3, and the mixture was extracted with ethyl acetate 3 times. The combined organic layers were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) to give the titled compound (75 mg, 0.159 mmol, 80% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 6.68 (d, J = 6.4 Hz, 2H), 5.96 (dd, J = 28.2, 2.9 Hz, 1H), 5.74 (dd, J = 22.2, 2.9 Hz, 1H), 3.82 (d, J = 12.5 Hz, 6H), 3.39 (t, J = 7.7 Hz, 2H), 3.24 - 3.03 (m, 2H), 2.60 (t, J = 7.6 Hz, 1H), 2.40 (t, J = 7.1 Hz, 1H), 2.26 (q, J = 8.1, 7.6 Hz, 1H), 2.20 (s, 1H), 2.08 (s, 3H), 1.88 (dd, J = 10.7, 5.0 Hz, 1H), 1.77 (p, J = 7.4 Hz, 1H), 1.54 (ddd, J = 29.5, 13.9, 7.7 Hz, 4H), 1.31 (q, J = 7.6 Hz, 1H); LC-MS (ESI) m/z 472.2 (M+H) ⁺ .

Example 178

5-{(4-cyclopropyl-3,5-dimethoxybenzoyl)[3-(5-methylfuran-2-y l)propyl]amino}pentanoic acid

[001236] Step 1 : methyl 5-{(4-cyclopropyl-3,5-dimethoxybenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } pentanoate

[001237] 4-Cyclopropyl-3,5-dimethoxybenzoic acid (52.6 mg, 0.237 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (108 mg, 0.284 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (92 mg, 0.711 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 133-Step 1 (60 mg, 0.237 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (96 mg, 0.210 mmol, 89% yield).

[001238] Step 2: 5-{(4-cyclopropyl-3,5-dimethoxybenzoyl)[3-(5-methylfuran-2- yl)propyl] amino jpentanoic acid

[001239] Example 178-Step 1 (100 mg, 0.219 mmol) was dissolved in tetrahydrofuran (2 mL) and lithium hydroxide (31.4 mg, 1.311 mmol) solution (2 mL) was added. The mixture was stirred for 2 hours at room temperature. The mixture was poured into water, the pH was adjusted to 3, and the mixture was extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) to give the titled compound (75 mg, 0.169 mmol, 77% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 6.47 (s, 2H), 5.86 (d, J = 42.1 Hz, 2H), 3.71 (s, 6H), 3.26 - 3.00 (m, 2H), 2.57 (s, 1H), 2.38 (s, 1H), 2.15 (d, J = 28.6 Hz, 5H), 1.84 (tt, J = 8.8, 5.9 Hz, 3H), 1.53 (s, 3H), 1.30 (s, 1H), 0.94 (dt, J = 5.8, 2.9 Hz, 2H), 0.74 (dt, J = 8.8, 3.0 Hz, 2H); LC-MS (ESI) m/z 444.2 (M+H) ⁺ .

Example 179

5- { (3 ,5 -dimethoxy-4-methylbenzoyl) [3-(5 -methylfuran-2-yl)propyl] amino } -2-methylpentanoic acid

[001240] Step 1 : methyl 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } pentanoate

[001241] To a solution of 3,5-dimethoxy-4-methylbenzoic acid (1.110 g, 5.66 mmol) in N,N- dimethylformamide (15 mL) was added l-[bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5- ¾]pyridinium 3-oxid hexafluorophosphate (2.152 g, 5.66 mmol, HATU) and diisopropylethylamine (4.94 mL, 28.3 mmol) at room temperature, and the mixture was stirred at room temperature for 10 minutes. Then Example 133-Step 1 (3.37 g, 5.66 mmol) was added and the resultant mixture was stirred at room temperature for another 2 hours. Water (20 mL) was added to the mixture followed by extraction with ethyl acetate (50 mL) twice. The combined organic fractions were dried over Na ₂ S0 ₄ and concentrated. The residue was purified by chromatography on silica gel eluted with hexanes and ethyl acetate (0-20%) to give the titled compound (2.19 g, 5.08 mmol, 90% yield). LC-MS (ESI) m/z 432.2 (M+H) ⁺ , RT = 2.11 minutes.

[001242] Step 2: methyl 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } -2-methylpentanoate

[001243] To a solution of diisopropylamine (0.875 mL, 6.14 mmol) in tetrahydrofuran (20 mL) was added «-butyllithium (3.84 mL, 6.14 mmol) at 0 °C under a N ₂ atmosphere. The mixture was stirred at 0 °C for 0.5 hour, and then cooled to -78 °C. Then a solution of Example 179-Step 1 (1.06 g, 2.456 mmol) in tetrahydrofuran (5 mL) was added to the mixture drop wise, and the mixture was stirred at - 78 °C for 1 hour. Then methyl iodide (0.461 mL, 7.37 mmol) was added to the mixture with continued stirring at -78 °C to room temperature over 2 hours. Then the reaction was quenched with saturated NH ₄ C1, and the mixture was extracted with ethyl acetate (30 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by chromatography on silica gel eluted with hexanes and ethyl acetate from 0-20% to give the titled compound (400 mg, 0.898 mmol, 36.5% yield) and Example 180-Step 1 (200 mg, 0.435 mmol, 17.72% yield). LC-MS (ESI) m/z 446.2 (M+H) ⁺ , RT = 2.17 minutes.

[001244] Step 3: 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2-yl)pro pyl]amino}-2- methylpentanoic acid

[001245] To a solution of Example 179-Step 2 (60 mg, 0.135 mmol) in tetrahydrofuran (5 mL) was added 1 N LiOH (1.347 mL 1.347 mmol), and the mixture was heated to 50 °C for 4 hours. Then the mixture was cooled to room temperature and concentrated. The residue was diluted with water (10 mL) and washed with ethyl ether (20 mL). The aqueous layer was acidified with 1 N HC1 to pH = 2-3, and extracted with ethyl acetate (30 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by high pressure liquid chromatography with water (0.5% CF ₃ C0 ₂ H) and acetonitrile to give the titled compound (40 mg, 0.093 mmol, 68.8% yield). 'H NMR (400 MHz, DMSO-<¾) δ ppm 12.14 (brs, 1H), 6.51 (d, J = 4.7 Hz, 2H), 5.96 (d, J = 27.5 Hz, 1H), 5.77 (d, J = 23.4 Hz, 1H), 3.76 (d, J = 3.8 Hz, 6H), 3.33 (d, J = 30.7 Hz, 2H), 3.14 (s, 2H), 2.58 (s, 1H), 2.45 - 2.29 (m, 1H), 2.29 - 2.04 (m, 3H), 1.94 - 1.66 (m, 2H), 1.66 - 1.41 (m, 3H), 1.35 (s, 2H), 1.15 - 0.85 (m, 3H); LC-MS (ESI) m/z 432.2 (M+H)+, RT = 2.00 minutes.

Example 180

5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2-yl)pro pyl]amino}-2,2-dimethylpentanoic acid

[001246] Step 1 : methyl 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2- yl)propyl] amino } -2,2-dimethylpentanoate

[001247] The titled compound was prepared as described in Example 179-Step 2. LC-MS (ESI) m/z 460 (M+H) ⁺ , RT = 2.23 minutes

[001248] Step 2: 5-{(3,5-dimethoxy-4-methylbenzoyl)[3-(5-methylfuran-2-yl)pro pyl]amino}-2,2- dimethylpentanoic acid

[001249] To a solution of Example 180-Step 1 (200 mg, 0.435 mmol) in 1,4-dioxane (5 mL) was added 1 N LiOH (4.35 mL 4.35 mmol) in H ₂ 0, and the mixture was heated to 70 °C overnight. Then the mixture was cooled to room temperature and concentrated. The residue was diluted with water and washed with ethyl ether (20 mL). The aqueous layer was acidified with 1 N HC1 to pH = 2-3, and extracted with ethyl acetate (30 mL). The organic layer was dried over Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by high pressure liquid chromatography eluted with acetonitrile and water (0.5% CF ₃ C0 ₂ H) to give the titled compound (143 mg, 0.321 mmol, 73.8% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.15 (brs, 1H), 6.50 (s, 2H), 5.96 (d, J = 28.0 Hz, 1H), 5.77 (d, J = 25.0 Hz, 1H), 3.75 (s, 6H), 3.34-3.35 (m, 2H), 3.22 - 3.04 (m, 2H), 2.56 (s, 1H), 2.34 (d, J = 21.6 Hz, 1H), 2.14 (d, J = 39.7 Hz, 3H), 1.81 (d, J = 36.5 Hz, 2H), 1.47 (s, 3H), 1.23 (d, J = 6.8 Hz, 1H), 1.16 - 0.89 (m, 6H); LC-MS (ESI) m/z 446.2 (M+H)+, RT = 2.08 minutes.

Example 181

3,5-dimethoxy-4-methyl-N-{ [(2R)-5-oxooxolan-2-yl]methyl}-N-(3-phenylpropyl)benzamide

[001250] Step 1 : ethyl (25,4R)-4-{ [teri-butyl(dimethyl)silyl]oxy}pyrrolidine-2-carboxylate

[001251] To a solution of (25,4R)-ethyl 4-hydroxypyrrolidine-2-carboxylate (0.68 g, 4.28 mmol) in CH ₂ C1 ₂ (10 mL) were added teri-butylchlorodimethylsilane (0.847 g, 5.62 mmol) and lH-imidazole (0.696 g, 10.22 mmol). The mixture was stirred overnight at room temperature and the solids were filtered off. The filtrate was concentrated under reduced pressure, and the residue was partitioned between ethyl acetate and water. The organic phase was separated, and the aqueous layer was back extracted with ethyl acetate. The combined organic fractions were washed with brine, dried over magnesium sulfate end concentrated under reduced pressure. The residue was dissolved in hexane (100 mL) and solids were filtered off. The filtrate was concentrated under vacuum to give the titled compound. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 4.42 (tt, J = 5.0, 2.6 Hz, 1H), 4.22 (dq, J = 14.3, 7.1 Hz, 2H), 4.10 (t, J = 8.1 Hz, 1H), 3.28 (dd, J = 11.6, 4.6 Hz, 1H), 2.94 (ddd, J = 11.7, 2.6, 1.3 Hz, 1H), 2.11 (dddd, J = 11.7, 7.9, 2.6, 1.2 Hz, 1H), 2.06 - 1.94 (m, 1H), 1.29 (dd, J = 7.7, 6.7 Hz, 3H), 0.89 - 0.86 (m, 9H), 0.09 - 0.04 (m, 6H).

[001252] Step 2: ethyl (25,4R)-4-{ [teri-butyl(dimethyl)silyl]oxy}-l-(3-phenylpropyl)pyrrolidin e-2- carboxylate

[001253] A mixture of Example 181-Step 1 (1 g, 3.66 mmol), (3-bromopropyl)benzene (0.946 g, 4.75 mmol) and acetonitrile (10 mL) was stirred at 70 °C for 0.5 hour. The mixture was concentrated to dryness. The residue was extracted with ethyl acetate, washed with brine, dried with Na ₂ S0 ₄ , filtered and concentrated to dryness. The residue was purified by flash column chromatography (eluent, ethyl acetate/hexane from 0/100 to 20/ 80) to give the titled compound. ¾ NMR (400 MHz, CDC1 ₃ ) δ ppm 7.29 - 7.25 (m, 2H), 7.21 - 7.13 (m, 3H), 4.44 (p, J = 5.2 Hz, 1H), 4.18 (q, J = 7.1 Hz, 2H), 3.44 (s, 2H), 2.89 - 2.46 (m, 4H), 2.35 (s, 1H), 2.17 (dt, J = 14.0, 7.2 Hz, 1H), 2.02 (ddd, J = 12.8, 7.6, 3.9 Hz, 1H), 1.25 (t, J = 7.1 Hz, 3H), 0.87 (s, 9H), 0.04 (d, J = 4.0 Hz, 6H); LC-MS (ESI) m/z 392.2 (M+H) ⁺ .

[001254] Step 3: ethyl (4R)-4-{ [teri-butyl(dimethyl)silyl]oxy}-5-[(3- phenylpropyl) amino] pentanoate

[001255] To a solution of Example 181-Step 2 (0.3 g, 0.766 mmol), hexamethylphosphoramide (0.666 mL 3.83 mmol), and tetrahydrofuran (5 mL) were added dropwise samarium(II) iodide (38.3 mL 3.83 mmol) and pivalic acid (0.222 mL 1.915 mmol) in tetrahydrofuran(2 mL) at 0 °C. The resulting solution was allowed to warm to room temperature. A stream of air was bubbled through the solution, and an excess of diatomaceous earth in diethyl ether and saturated aqueous NaHC0 ₃ (1 mL) were added. The solution was filtered, and the filtrate was washed with brine. The organic layer was separated, dried and concentrated to give the titled compound. LC-MS (ESI) m/z 394.2 (M+H) ⁺ .

[001256] Step 4: ethyl (4R)-4-{ [teri-butyl(dimethyl)silyl]oxy}-5-[(3,5-dimethoxy-4- methylbenzoyl)(3-phenylpropyl)amino]pentanoate

[001257] A mixture of 3,5-dimethoxy-4-methylbenzoic acid (0.050 g, 0.254 mmol), Example 181- Step 3 (0.1 g, 0.157 mmol, 62.0% yield), 2-(3H-[l,2,3]triazolo[4,5 ]pyridin-3-yl)-l, 1,3,3- tetramethylisouronium hexafluorophosphate(V) (0.097 g, 0.254 mmol), N-ethyl-N-isopropylpropan-2- amine (0.089 mL 0.508 mmol) and N,N-dimethylformamide (1 mL) was stirred at room temperature for 1 hour. The mixture was extracted with ethyl acetate (3x20 mL). The combined organic fractions were washed with brine, dried with Na ₂ S0 ₄ , filtered and concentrated to dryness. The residue was purified by flash column chromatography on silica gel (eluent, ethyl acetate/hexane from 0/100 to 20/80) to give the titled compound. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.24 - 7.13 (m, 3H), 6.96 (dd, J = 14.5, 6.8 Hz, 2H), 6.51 (s, 2H), 4.19 - 4.06 (m, 3H), 3.82 - 3.73 (m, 6H), 3.55 (s, 1H), 3.42 - 3.21 (m, 3H), 2.70 (s, 1H), 2.44 (d, J = 10.6 Hz, 3H), 2.10 (s, 3H), 1.90 (s, 4H), 1.26 (d, J = 7.8 Hz, 3H), 0.93 - 0.82 (m, 9H), 0.10 (tt, J = 7.7, 5.6, 4.6 Hz, 4H), 0.00 -0.11 (m, 2H); LC-MS (ESI) m/z 572.4 (M+H) ⁺ .

[001258] Step 5: 3,5-dimethoxy-4-methyl-N-{ [(2R)-5-oxooxolan-2-yl]methyl}-N-(3- phenylpropyl)benzamide

[001259] A mixture of Example 181-Step 4 (40 mg, 0.070 mmol), tetra-«-butylammonium fluoride (36.6 mg, 0.140 mmol) and tetrahydrofuran (2 mL) was stirred at room temperature overnight. The mixture was extracted with ethyl acetate (3x20 mL). The combined organic layers were washed with brine, dried with Na ₂ S0 ₄ , filtered and concentrated to dryness. The residue was purified by flash column chromatography on silica gel (eluent, ethyl acetate/hexane from 0/100 to 40/60) to give the titled compound. *H NMR (400 MHz, CDC1 ₃ ) δ ppm 7.18 (dq, J = 14.1, 7.3, 6.9 Hz, 3H), 7.00 (s, 2H), 6.47 (s, 2H), 4.91 (s, 1H), 4.13 (d, J = 14.2 Hz, 1H), 3.80 (s, 6H), 3.43 (s, 2H), 3.24 (dd, J = 14.6, 7.4 Hz, 1H), 2.62 - 2.53 (m, 2H), 2.51 - 2.34 (m, 3H), 2.10 (s, 3H), 1.91 (d, J = 21.4 Hz, 3H); LC-MS (ESI) m/z 412.4 (M+H) ⁺ .

Example 182

5 - [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylbutyl)amino] pentanoic acid

[001260] Step 1 : methyl 5-[(3-phenylbutyl)amino]pentanoate

[001261] 3-Phenylbutan-l-amine (200 mg, 1.340 mmol) and potassium carbonate (222 mg, 1.608 mmol) were dissolved in dry CH ₃ CN (6 mL) at room temperature. Methyl 5-bromopentanoate (288 mg, 1.474 mmol) dissolved in dry CH ₃ CN was added slowly to the mixture, and then the mixture was stirred at reflux for 3 hours. Then the mixture was cooled down and filtered. The filtrate was concentrated to give the titled compound (81 mg, 0.308 mmol, 23% yield).

[001262] Step 2: methyl 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylbutyl)amino]penta noate

[001263] 3,5-Dimethoxy-4-methylbenzoic acid (263 mg, 1.340 mmol) and 1- [bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-¾]pyrid inium 3-oxid hexafluorophosphate (611 mg, 1.608 mmol, HATU) were dissolved in a mixture of dry N,N-dimethylformamide (1 mL), tetrahydrofuran (1.000 mL) and N,N-diisopropylethylamine (520 mg, 4.02 mmol). The mixture was stirred for 20 minutes at room temperature. Then Example 182-Step 1 (353 mg, 1.34 mmol) was added, and the mixture was stirred for another 3 hours at room temperature. The mixture was poured into water and extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by flash column chromatography on silica gel (loaded directly with CH ₂ C1 ₂ ) eluted with hexanes and ethyl acetate (0-50%) to give the titled compound (65 mg, 0.147 mmol, 10.99% yield).

[001264] Step 3: 5-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylbutyl)amino]penta noic acid

[001265] Example 182-Step 2 (75 mg, 0.170 mmol) was dissolved in tetrahydrofuran (2 mL) and lithium hydroxide (24.41 mg, 1.019 mmol) solution (2 mL) was added. The mixture was stirred for 12 hours at room temperature. The mixture was poured into water, the pH was adjusted to 5, and the mixture was extracted with ethyl acetate 3 times. The combined organic fractions were washed with brine, dried over Na ₂ S0 ₄ , and concentrated. The residue was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) to give the titled compound (56 mg, 0.131 mmol, 77% yield). H NMR (400 MHz, DMSO-i¾) δ ppm 12.02 (s, 1H), 7.46 - 6.84 (m, 5H), 6.56 - 6.30 (m, 2H), 3.73 (d, J = 8.2 Hz, 7H), 3.22 - 2.84 (m, 3H), 2.23 (s, 1H), 2.12 - 2.02 (m, 1H), 1.98 (s, 3H), 1.78 (d, J = 49.8 Hz, 2H), 1.45 (d, J = 31.3 Hz, 3H), 1.23 (s, 2H), 1.03 (d, J = 6.8 Hz, 2H); LC-MS (ESI) m/z 428.2 (M+H) ⁺ .

Example 183

2- [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethyl (4-fluorobenzene- 1 - sulfonyl)carbamate

[001266] To a solution of N-(2-hydroxyethyl)-3,5-dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide (300 mg, 0.839 mmol, Example 6-Step 4) in diethyl ether (10 mL) was added 4-fluorobenzenesulfonyl isocyanate (169 mg, 0.839 mmol) dropwise. The solution was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate, washed with brine, dried (MgS0 ₄ ) and concentrated. Flash chromatography on silica gel (0-100% i-butyl methyl ether in heptanes) gave the titled compound (190 mg, 40%). 'H NMR (400 MHz, DMSO- ¾) δ ppm 1.87 (p, / = 7.7 Hz, 2H), 1.99 (s, 3H), 2.53 (t, / = 7.7 Hz, 2H), 3.32 - 3.44 (m, 4H), 3.53 (t, / = 6.1 Hz, 2H), 3.75 (s, 6H), 6.54 (s, 2H), 6.95 - 7.27 (m, 6H), 7.27 - 7.40 (m, 2H), 7.77 - 8.00 (m, 2H); MS (DCI) m/z 559 (M+H) ⁺ .

Example 184

2- [(3 , 5 -dimethoxy-4-methylbenzoyl) (3 -phenylpropyl) amino] ethyl (methanesulfonyl)carbamate

[001267] To a solution of N-(2-hydroxyethyl)-3,5-dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide (200 mg, 0.560 mmol, Example 6-Step 4) in i-butyl methyl ether (10 mL) was added freshly prepared methanesulfonyl isocyanate (1.119 mL, 1.119 mmol) (in toluene ) dropwise. The mixture was stirred at room temperature overnight and then concentrated. The residue was partitioned between ethyl acetate and brine. The organic layer was dried (MgS0 ₄ ) and concentrated. Flash chromatography on silica gel (0-100% i-butyl methyl ether/heptanes) gave the titled compound (34 mg, 13%). *H NMR (400 MHz, DMSO-<¾) δ ppm 1.86 (m, 2H), 1.97 (s, 3H), 2.47 (m, 1H), 2.89 (s, 3H), 3.36 (m, 3H), 3.53 (t, / = 6.2 Hz, 2H), 3.61 (m, 1H), 3.75 (s, 6H), 4.41 (s, 1H), 6.54 (m, 2H), 7.05 - 7.21 (m, 5H), 7.21 (s, 1H); MS (DCI) nt/z 479 (M+H) ⁺ .

Example 185

5-{ [3-(5-chlorofuran-2-yl)propyl](3,5-dimethoxy-4-methylbenzoyl )amino}pentanoic acid

[001268] Step 1 : methyl 5-{ [3-(5-chlorofuran-2-yl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino jpentanoate

[001269] To a solution of Example 173-Step 2 (240 mg, 0.575 mmol) in CC1 ₄ (1.5 mL) was added N-chlorosuccinimide (84 mg, 0.632 mmol) in one portion. Then the mixture was stirred at 70 °C for 15 minutes, and then the mixture was heated for an additional 25 minutes. The mixture was diluted with CH ₂ C1 ₂ and washed with water once, dried over anhydrous Na ₂ S0 ₄ , filtered and concentrated to give a residue which was purified by flash column chromatography on silica gel eluted with ethyl acetate in hexanes (0-40%) to give the titled compound (117 mg, 0.236 mmol, 41.0% yield). LC-MS (ESI) nt/z 452.4 (M+H) ⁺ , RT = 2.453 minutes.

[001270] Step 2: 5-{ [3-(5-chlorofuran-2-yl)propyl](3,5-dimethoxy-4- methylbenzoyl)amino jpentanoic acid

[001271] To a solution of Example 185-Step 1 (117 mg, 0.259 mmol) in tetrahydrofuran (2 mL) was added 1 N lithium hydroxide (1.553 mL 1.553 mmol). The mixture was stirred at room temperature for 1 hour. The mixture was concentrated under vacuum, and the aqueous residue was washed with ethyl ether twice and then acidified with 1 N HC1 to pH=2-3. The acid aqueous mixture was extracted with ethyl acetate 3 times. The combined organic layers were dried and concentrated. The residue was purified by preparative HPLC (0.1 % CF ₃ C0 ₂ H in H ₂ 0/CH ₃ CN) and lyophilized to give the titled compound (51 mg, 0.116 mmol, 45.0% yield). *H NMR (400 MHz, DMSO-<¾) δ ppm 12.09 (s, 1H), 6.50 (s, 2H), 6.30 (d, J = 25.2 Hz, 1H), 6.11 (d, J = 76.1 Hz, 1H), 3.75 (s, 6H), 3.37 (s, 2H), 3.17 (s, 2H), 2.63 (s, 1H), 2.41 (s, 1H), 2.25 (s, 1H), 2.09 (s, 1H), 1.98 (s, 3H), 1.87 (s, 1H), 1.77 (s, 1H), 1.64 - 1.40 (m, 3H), 1.28 (s, 1H); LC-MS (ESI) nt/z 438.2 (M+H) ⁺ , RT = 1.964 minutes.

Example 186

3-[(3,5-dimethoxy-4-methylbenzoyl)(3-phenylpropyl)amino]prop yl (methanesulfonyl)carbamate

[001272] To a solution of N-(3-hydroxypropyl)-3,5-dimethoxy-4-methyl-N-(3- phenylpropyl)benzamide (150 mg, 0.404 mmol, Example 145-Step 1) in i-butyl methyl ether (10 mL) was added a solution of methanesulfonyl isocyanate (48.9 mg, 0.404 mmol) dropwise in toluene, and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate, washed with brine, dried (MgS0 ₄ ) and concentrated. Flash chromatography on silica gel (0- 100% i-butyl methyl ether/heptanes) gave the titled compound (60 mg, 28%). ¾ NMR (400 MHz, DMSO-i¾) δ ppm 1.80 (m, 4H), 1.96 (s, 3H), 2.34 (m, 2H), 2.68 (m, 2H), 3.19 (m, 4H), 3.39 - 3.53 (m, 1H), 3.72 (s, 6H), 3.85 - 4.29 (m, 2H), 6.49 (s, 2H), 7.08 (m, 5H), 11.55 (s, 1H); MS (DCI) nt/z 493 (M+H) ⁺ .

Determination of Biological Activity

[001273] Abbreviations: BSA for bovine serum albumin; CRC for concentration-response curve; dFBS for dialyzed fetal bovine serum; DMEM for Dulbecco's modified Eagle's medium; DMSO for dimethyl sulfoxide; FLIPR for fluorescence imaging plate reader; FRET for fluorescence resonance energy transfer; HBSS for Hank's buffered salt solution; HEPES for 4-(2-hydroxy ethyl)- 1- piperazineethanesulfonic acid; HTRF for heterogeneous time resolved fluorescence; LPA for lysophosphatidic acid; PDL for poly-D -lysine; po for per os (by mouth); rpm for revolutions per minute; and TC -treated for tissue culture treated.

LPARl arrestin assay.

[001274] One day prior to the experiment, frozen U20S cells stably expressing the LPARl receptor (Life Technologies, Grand Island, NY, #K1519A) were thawed, centrifuged at 1,000 rpm for 5 minutes to remove DMSO, and resuspended in FreeStyle™ media (Gibco, Grand Island, NY). Forty microliters of cells were plated into PDL-coated 384-well plates (Greiner Bio-One, Monroe, NC) at 10,000 cells/well, and then the plates were incubated overnight in humidified 5% C0 ₂ at 37 °C. Test compounds were dissolved in DMSO, and 12-point, 1:3 dilution CRCs were prepared in duplicate; daughter plates were prepared by aliquoting 0.8 μίΛνεΙΙ of test compound dilutions into 384-well plates. On the day of the assay, the daughter plates were diluted to 6X stocks using HEPES -buffered HBSS, then 10 μL· of 6X test compounds were added to the cells, and the plates were incubated at 37 °C for one hour. After this 1 hour incubation, 10 of a 6X stock of the LPARl agonist, 18: 1 LPA (Avanti Polar Lipids, Alabaster, AL), was prepared in HEPES -buffered HBSS + 0.1% fatty acid-free BSA (Sigma, St. Louis, MO). The 6X LPA was added to all wells for a final concentration of 200 nM, which corresponds to the 18:1 LPA EC ₈₀ in this arrestin assay. The final DMSO concentration in the assay plate was 0.1%, and the final BSA concentration was 0.02%. After addition of LPA to all wells, the assay plates were incubated in humidified 5% C0 ₂ at 37 °C for five hours. During the incubation period, 6X dye from the LiveB L Azer™-FRET B/G with CCF4-AM kit (Life

Technologies, Grand Island, NY) was prepared according to manufacturers' instructions. At the end of the 5 hour compound incubation, 10 μL· of 6X dye was added to each well, and the assay plate was incubated for two hours in the dark at room temperature. Throughout the assay procedure, all volume additions were performed with a Biomek® NX liquid handler (Beckman Coulter, Indianapolis, IN). After the 2 hour dye -load, fluorescence was measured on an EnVision® Multilabel Plate Reader (Perkin Elmer, Waltham, MA) with an excitation filter at 409/20 nm and emission filters at 460/40 nm and 530/30 nm. Data processing was performed as recommended by the LiveBLAzer™-FRET B/G with CCF4-AM kit manual; all test compound CRCs were performed in duplicate with n>3.

Table 1. Arrestin Reporter Assay Data

LPARl FLIPR® Assay

[001275] U20S cells stably expressing LPARl (Life Technologies #K1519A) were plated at 12000 cells/well in growth medium (McCoy's 5 A medium(Life Technologies 16600-082)) with 10% dFBS (Life Technologies 26400-036), 0.1 mM non-essential amino acids, 25 mM HEPES, 1 mM sodium pyruvate, 1% penicillin/streptomycin, 50 μg/mL hygromycin, and 100 μg/mL Geneticin® in black- walled, clear-bottom 384-well plates (Corning #3683) and incubated in humidified 5% C0 ₂ at 37 °C overnight. On the day of the assay, medium was removed and 30 μL· of 5% Calcium 6 FLIPR dye in assay buffer-HBSS (Life Technologies #14025) containing 20 mM HEPES (Life Technologies #15630-080) was added to the cells. Cells were incubated at 37 °C in the dark for 2 hours.

Compounds were 3-fold serial diluted from 10 mM for 11-points using dimethyl sulfoxide. 1 μΕ of compound in DMSO was diluted in 82.3 μL· assay buffer immediately before the assay. Using a FLIPR® TETRA® system, 15 of the (4x) compound solutions were first added to the cells, then 15 μL of LP A (EC ₈ o) diluted in of assay buffer supplemented with 0.1% BSA was added 3 minutes later to activate the receptor. Changes in fluorescence were measured at wavelengths of 515-575 nm over the course of the experimental run. IC ₅₀ values were calculated from curve fits of the ratio data using a four-parameter logistic Hill equation (Assay Explorer 3.3 Client).

Table 2. LPARl FLIPR® Assay Data

Maximum Maximum

Example ICso (μΜ) Inhibition Example ICso (μΜ) Inhibition

(%) (%)

15 0.290 59 108 0.026 94

16 0.985 70 109 0.015 93

17 3.982 61 110 0.016 90

18 0.050 89 111 0.028 95

19 0.071 98 112 0.315 77

20 0.020 99 113 0.032 87

21 0.224 82 114 0.671 76

22 0.054 89 115 0.030 78

23 12.643 53 116 0.020 88

24 0.481 58 117 0.010 93

25 29.261 48 118 0.247 78

26 >30.000 50 119 0.097 92

27 1.061 65 120 0.039 81

28 0.398 72 121 0.503 86

29 0.309 79 122 0.010 95

30 0.042 96 123 0.046 94

31 0.045 87 124 0.059 92

32 0.018 98 125 > 10.000 32

33 0.019 99 126 0.119 74

34 0.024 96 127 > 10.000 7

35 0.032 98 128 0.023 89

36 0.600 83 129 0.020 93

37 0.032 96 130 0.041 83

38 0.014 99 131 0.021 86

39 0.054 96 132 0.010 86

40 29.302 45 133 0.046 78

41 0.022 97 134 0.074 77

42 0.236 90 135 > 10.000 32

43 23.283 55 136 > 10.000 15

44 0.008 96 137 0.092 64

45 0.051 91 138 0.013 89

46 0.128 66 139 0.046 78 Maximum Maximum

Example ICso (μΜ) Inhibition Example ICso (μΜ) Inhibition

(%) (%)

47 0.079 88 140 0.143 89

48 0.052 81 141 0.028 94

49 24.262 58 142 0.076 88

50 0.003 101 143 0.081 83

51 0.238 62 144 0.099 92

52 0.124 87 145 0.437 51

53 0.239 63 146 0.046 89

54 0.015 100 147 0.031 93

55 0.022 100 148 > 10.000 47

56 0.021 95 149 0.838 72

57 0.035 100 150 0.045 73

58 0.032 93 151 0.037 79

59 0.023 100 152 0.085 88

60 0.020 95 153 0.127 83

61 0.020 98 154 0.225 69

62 0.029 97 155 0.027 90

63 0.080 87 156 0.021 99

64 1.226 54 157 0.016 92

65 5.023 49 158 0.511 98

66 0.312 71 159 0.302 85

67 >30.000 46 160 8.020 63

68 0.902 52 161 0.099 99

69 >30.000 38 162 0.076 100

70 0.056 98 163 0.244 57

71 0.012 91 164 0.237 76

72 0.026 99 165 0.045 83

73 0.060 65 166 0.042 96

74 0.079 67 167 0.635 58

75 0.020 72 168 1.102 62

76 0.048 76 169 3.094 71

77 0.020 100 170 0.333 81

78 0.033 100 171 0.933 70 Maximum Maximum

Example ICso (μΜ) Inhibition Example ICso (μΜ) Inhibition

(%) (%)

79 >30.000 13 172 1.463 63

80 >30.000 37 173 0.029 74

81 >30.000 31 174 0.033 73

82 >30.000 39 175 0.048 73

83 >30.000 25 176 0.084 64

84 >30.000 7 177 0.235 57

85 >30.000 14 178 0.045 84

86 0.044 88 179 0.046 97

87 0.081 71 180 0.048 100

88 0.293 91 181 0.486 80

89 0.036 95 182 0.047 91

90 0.037 88 183 > 10.000 30

91 0.025 89 184 0.131 66

92 0.060 90 185 0.013 91

93 0.043 96 186 0.065 83

LPAR2 FLIPR® Assay

[001276] U20S cells stably expressing LPAR2 (Life Technologies #K1442) were plated at 12000 cells/well in growth medium (McCoy' s 5A(Life Technologies 16600-082)) with 10% dFBS (Life Technologies 26400-036), 0.1 mM non-essential amino acids, 25 mM HEPES, 1 mM sodium pyruvate, 1 % penicillin/streptomycin, 50 μg/mL hygromycin, and 100 μg/mL Geneticin® in black- walled, clear-bottom 384-well plates (Corning # 3683) and incubated in humidified 5% C0 ₂ at 37 °C overnight. On the day of the assay, medium was removed and 30 μL· of 5% Calcium 6 FLIPR dye in assay buffer-HBSS (Life Technologies #14025) containing 20 mM HEPES (Life

Technologies#l 5630-080) was added to the cells. Cells were incubated at 37 °C in the dark for 2 hours. Compounds were 3-fold serial diluted from 10 mM for 11-points using dimethyl sulfoxide. 1 μΕ of compound in DMSO was diluted in 82.3 μL· of assay buffer immediately before the assay. Using a FLIPR® TETRA® system, 15 μL· of the (4x) compound solutions were first added to the cells, then 15 of LP A (EC ₈₀ ) diluted in assay buffer supplemented with 0.1% BSA were added 3 minutes later to activate the receptor. Changes in fluorescence were measured at wavelengths of 515- 575 nm over the course of the experimental run. IC ₅₀ values were calculated from curve fits of the ratio data using a four-parameter logistic Hill equation (Assay Explorer 3.3 Client). LPAR3 FLIPR® Assay

[001277] U20S cells stably expressing LPAR3 (Life Technologies #K1849A) were plated at 12000 cells/well in growth medium (McCoy' s 5A(Life Technologies 16600-082)) with 10% dFBS (Life Technologies 26400-036), 0.1 mM non-essential amino acids, 25 mM HEPES, 1 mM sodium pyruvate, 1 % penicillin/streptomycin, 50 μg/mL hygromycin, and 100 μg/mL Geneticin® in black- walled, clear-bottom 384-well plates (Corning # 3683) and incubated in humidified 5% C0 ₂ at 37 °C overnight. On the day of the assay, medium was removed and 30 μL· of 5% Calcium 6 FLIPR dye in assay buffer-HBSS (Life Technologies #14025) containing 20 mM HEPES (Life

Technologies#l 5630-080) was added to the cells. Cells were incubated at 37 °C in the dark for 2 hours. Compounds were 3-fold serial diluted from 10 mM for 11-points using dimethyl sulfoxide. 1 μΕ of compound in DMSO was diluted in 82.3 μL· assay buffer immediately before the assay. Using a FLIPR® TETRA® system, 15 μL· of the (4x) compound solutions were first added to the cells, then 15 μL· of LPA (EC ₈ o) diluted in assay buffer supplemented with 0.1 % BSA were added 3 minutes later to activate the receptor. Changes in fluorescence were measured at wavelengths of 515-575 nm over the course of the experimental run. IC ₅₀ values were calculated from curve fits of the ratio data using a four-parameter logistic Hill equation (Assay Explorer 3.3 Client).

IP-one HTRF® Assay

[001278] U20S cells stably expressing LPARl (Life Technologies #K1519A) were plated at 20000 cells/well in growth medium (McCoy' s 5A(Life Technologies #16600-082)) with 10% dFBS (Life Technologies #26400-036), 0.1 mM non-essential amino acids, 25 mM HEPES, 1 mM sodium pyruvate, 1 % penicillin/streptomycin, 50 μg/mL hygromycin, and 100 μg/mL Geneticin® in tissue culture treated 384-well white plates (Greiner #781080) in humidified 5% C0 ₂ at 37 °C overnight. On the day of the assay, culture medium was replaced with 30 μΕΛνεΙΙ of McCoy's 5 A with 0.1 % BSA. Cells were incubated in humidified 5% C0 ₂ at 37 °C for 3 more hours. Compounds were 3- fold serial diluted from 2 mM for 11-points using dimethyl sulfoxide. 1 μΕ of compound in DMSO was diluted in 50 μΐ, stimulation buffer from an IP-One Tb HTRF kit (Cisbio # 62IPAPEB) immediately before assay. 15 μΕΛνεΙΙ of 1.33x compound in stimulation buffer was added to cells after removal of culture medium. After 20 minutes of incubation at 37 °C, 5 μΕΛνεΙΙ of 8 μΜ LPA diluted in stimulation buffer with 0.1% fatty acid free BSA was added to cells. High control wells used stimulation buffer for substitution. To EC ₁₀₀ wells were added 4x20 μΜ LPA. To the cells were added 5 μΕΛνεΙΙ IPl-d2 conjugate and 5 μLwεll IP1-K antibody after 2 hours of incubation at 37 °C. Cells were incubated at room temperature for 1 hour (protected from light). The plate was then read at 665 nm and 615 nm using an En Vision® Multilabel Plate Reader. IC50 values were calculated from curve fits of the ratio data using a four-parameter logistic Hill equation (Assay Explorer 3.3 Client). Table 3. IP-one HTRF® Assay Data

LPA-induced MCP-1 AlphaLISA® assay

[001279] Two days prior to the experiment, NRK-49F cells were plated at 8,000 cells/well in 100 μL· of growth medium [DMEM (Life Technologies #11995) with 5% dFBS (Life Technologies #30067-334), 100 units/mL penicillin/streptomycin (Life Technologies #15140122)] in 96-well clear flat bottom polystyrene TC -treated microplate (Corning® # 3599) and incubated in humidified 10% C0 ₂ at 37 °C. One day prior to the experiment, the cell medium was removed and serum free medium [100 μίΛνεΙΙ, DMEM (Life Technologies #11995) with 0.1% fatty acid free BSA (Sigma #A6003)] was added with continued incubation in humidified 10% C0 ₂ at 37 °C overnight. On the day of the assay, test compounds were 1 :3 serially diluted in 100% DMSO using a BioTek Precision™ system and then transferred (equivalent volume of DMSO as controls) to a plate in serum free medium

[DMEM with 0.1% fatty acid free BSA] using a Biomek® NX workstation to give a 2x compound solution. The cell culture medium was removed, and cells were pre-treated with 50 μΕΛνεΙΙ of 2x compound in serum free medium [DMEM with 0.1% fatty acid free BSA] at 37 °C for 30 minutes. Following the incubation, 50 μΕΛνεΙΙ of 20 μΜ LPA diluted in serum free medium [DMEM with 0.1% fatty acid free BSA] was added to the cells. Serum free medium [DMEM with 0.1% fatty acid free BSA] was used as substitution for low control wells while 20 μΜ LPA was added to high control wells and test compound wells. 200 μΜ LPA was added to EC ₁₀ o wells. Final DMSO concentration was 1% in every well. Final LPA concentration in test compound wells and high control wells was 10 μΜ. Final LPA concentration in EC ₁₀ o wells was 100 μΜ. The cell plate was incubated for 7 hours in humidified 10% C0 ₂ at 37 °C. After the incubation, cell supernatant was transferred to a new 96 well polypropylene plate (Greiner # 651201) where it was sealed and stored at -80 °C. On the detection day, 5 μL· of thawed cell supernatant was transferred to a new white opaque 384-well microplate (Perkin Elmer # 6007299). An AlphaLISA® mouse/rat CCL2/MCP1, Immunoassay Research kit (PerkinElmer #AL509F) was used. A mixture (20 μίΛνεΙΙ) of AlphaLISA® Anti- Analyte Accept beads (10 μg/mL final) and Biotinylated Antibody Anti-Analyte (freshly prepared, 1 nM final) was added. The mixture in the wells was mixed and then incubated at room temperature for 1 hour. Then SA-Donor beads (25 μΕΛνεΙΙ, 40 μg/mL final) were added giving a final volume of 50 μΕΛνεΙΙ. Τΐιε contents of the wells were mixed and then incubated at room temperature for 0.5 hour (protect from light). The plate was read using the default Envision™ Alpha protocol (PerkinElmer). IC50 values were calculated from curve fits of the ratio data using a four-parameter logistic Hill equation (Assay Explorer 3.3 Client). Table 4. LPA-induced MCP-1 AlphaLISA® assay data

Maximum Maximum

Example ICso (μΜ) Inhibition Example ICso (μΜ) Inhibition

(%) (%)

55 0.111 93 135 > 10.000 25

56 1.239 79 136 > 10.000 47

57 0.039 97 137 > 10.000 28

58 2.389 78 138 1.008 85

59 0.127 93 139 3.151 72

60 1.547 84 141 0.143 84

61 0.147 92 142 0.831 90

62 0.184 94 143 1.351 66

63 5.530 51 144 1.093 96

67 3.715 57 145 3.963 59

69 1.663 62 146 0.807 79

70 0.637 90 147 0.665 86

73 5.155 79 148 > 10.000 40

74 3.877 77 150 2.028 67

75 3.250 65 151 1.634 79

76 >10.000 36 152 6.174 64

77 0.060 92 155 0.763 81

78 0.078 95 157 0.460 77

79 >10.000 36 161 0.079 88

80 >10.000 37 162 0.007 94

81 >10.000 33 165 2.731 70

82 >10.000 2 166 1.063 80

83 >10.000 11 167 > 10.000 25

84 >10.000 31 170 > 10.000 50

85 >10.000 12 171 >2.177 30

86 2.977 74 173 4.535 64

87 5.437 62 174 5.429 65

89 4.697 65 175 3.943 67

90 2.498 76 176 >8.186 53

91 2.093 84 178 1.974 77

92 4.489 72 179 1.983 74

93 0.819 84 180 0.105 93 Maximum Maximum

Example ICso (μΜ) Inhibition Example ICso (μΜ) Inhibition

(%) (%)

94 >10.000 13 182 0.994 85

95 >10.000 18 184 5.562 58

96 >10.000 52 185 0.536 84

97 0.036 94 186 7.046 54

Mouse unilateral ureteral obstruction kidney fibrosis model

[001280] All animal handling and experimental protocols were approved by AbbVie's Institutional Animal Care and Use Committee (IACUC) and were conducted in accordance with the ethical principles for pain-related animal research of the American Pain Society. Male CD-I mice (28-30 g, Charles River) were group housed 10 per cage, housed in a temperature controlled room with a 12/12- hour day/night cycle, with food (2018 Tekland Global 18% protein rodent diet, Harlan®) and water available ad libitum. Mice underwent either complete unilateral ureter obstruction (UUO) or sham surgery to the left kidney. Briefly, animals were anesthetized with isoflurane, and the left ureter was visualized via a flank incision. Using 6-0 silk sutures, the ureter was tied off at two points near the renal pelvis and then completely cut between ligations (ligation step omitted for sham operated animals). The abdominal muscle was sutured and the skin closed using standard wound clips. Test compound or vehicle was delivered twice daily (30 mg/kg, po) via oral gavage, starting on the day before surgery (D-l) and continuing through day 6 after surgery (D6), at which time animals were sacrificed and kidney tissues collected. The renal capsule was removed from the kidney, and the tissue was cut into 2 sagittal sections. One section of the kidney was fixed in 10% neutral buffered formalin for histological assessment of tubulointerstitial collagen deposition using picrosirius red (PSR) staining. A biopsy punch (3 mm diameter) was taken from the remaining kidney segment and transferred to RNA-later for expression analysis (PCR) of the collagen, type I, alpha l(Collal) mRNA. Statistical significance was determined by using a one-way analysis of variance (ANOVA) followed by a Bonferroni post-hoc test and was conducted using GraphPad prism.

[001281] Results:

[001282] As shown in FIG. 1 , there was a significant increase in interstitial collagen deposition (PSR) and Collal expression in vehicle -treated UUO mice (black bars) as compared to sham controls (white bars) on day 6 post surgery. UUO animals treated with Example 7 (striped bars) showed a significant reduction in both tubulointerstitial fibrosis as measured by PSR (-53%) and Collal expression (-46%) compared to the vehicle treated UUO group (black bars).

[001283] It is understood that the foregoing detailed description and accompanying examples are merely illustrative and are not to be taken as limitations upon the scope of the present disclosure, which is defined by the appended claims and their equivalents. Various changes and modifications to the described embodiments will be apparent to those skilled in the art. Such changes and modifications, including without limitation those relating to the chemical structures, substituents, derivatives, intermediates, syntheses, formulations, or methods, or any combination of such changes and modifications of use of the present disclosure, may be made without departing from the spirit and scope thereof.