Title:
TETRACYCLIC PYRIMIDINONE COMPOUND, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/063145
Kind Code:
A1
Abstract:
Disclosed is a tetracyclic pyrimidinone compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, wherein same has the structure as shown in formula (I), is a completely new Lp-PLA2 inhibitor, and can be used for treating neurodegenerative-related diseases, such as Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), or cardiovascular diseases including atherosclerosis, etc.
Inventors:
XIAO QIONG (CN)
GU ZHENGHUA (CN)
HU YOUHONG (CN)
GU ZHENGHUA (CN)
HU YOUHONG (CN)
Application Number:
PCT/CN2020/112802
Publication Date:
April 08, 2021
Filing Date:
September 01, 2020
Export Citation:
Assignee:
NEUSCO BIOTECH LTD (CN)
International Classes:
A61K31/519; C07D487/04; A61P9/10; A61P25/28; C07D487/14; C07D487/22
Foreign References:
| CN106536525A | 2017-03-22 | |||
| CN106536521A | 2017-03-22 | |||
| CN103827118A | 2014-05-28 | |||
| CN103827116A | 2014-05-28 | |||
| CN105008365A | 2015-10-28 | |||
| CN104968665A | 2015-10-07 | |||
| CN105008368A | 2015-10-28 | |||
| CN105777653A | 2016-07-20 | |||
| CN1479724A | 2004-03-03 |
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WILENSKY ET AL., CURRENT OPINION IN LIPIDOLOGY, vol. 20, 2009, pages 415 - 420
FITZPATRICK ALIRIZARRY MCCUSHMAN MJENNY NSCHI GCKORO C, ATHEROSCLEROSIS, vol. 235, 2014, pages 384 - 391
STAURENGHI GYE LMAGEE MHDANIS RPWURZELMANN JADAMSON PMCLAUGHLIN MM: "Darapladib DMESG", OPHTHALMOLOGY, vol. 122, 2015, pages 990 - 996
BERTILSSON HTESSEM MBFLATBERG AVISET TGRIBBESTAD IANGELSEN AHALGUNSET J, CLIN CANCER RES., vol. 18, 2012, pages 3261 - 3269
HARDY J ET AL., SCIENCE, vol. 297, 2002, pages 353 - 356
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CHIANG KKOO EH, ANNU REV PHARMACOL TOXICOL., vol. 54, 2014, pages 381 - 405
AWASTHI MSINGH SPANDEY VPDWIVEDI UN, J NEUROL SCI., vol. 361, 2016, pages 256 - 271
VAN OIJEN ET AL., ANNALS OF NEUROLOGY, vol. 59, 2006, pages 139
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KASSNER ET AL., CURRENT ALZHEIMER RESEARCH, vol. 5, 2008, pages 358 - 366
DILDAR ET AL., ALZHEIMER DIS ASSOC DISORD, vol. 24, April 2010 (2010-04-01)
SINEM ET AL., CURRENT ALZHEIMER RESEARCH, vol. 7, 2010, pages 463 - 469
COLANGELO ET AL., JOURNAL OF NEUROSCIENCE RESEARCH, vol. 70, 2002, pages 462 - 473
WYSS-CORAY, NATURE MEDICINE, 12 September 2006 (2006-09-12)
BUSCHINI ET AL., PROGRESS IN NEUROBIOLOGY, vol. 95, 2011, pages 14 - 25
TEZEL, PROGRESS IN BRAIN RESEARCH, vol. 173, ISSN: 0079-6123
TEW DGBOYD HFASHMAN STHEOBALD CLEACH CA, BIOCHEMISTRY, vol. 37, 1998, pages 10087 - 10093
JEONG TSKIM MJYU HKIM HSCHOI JKKIM SSLEE WS, BIOORG MED CHEM LETT, vol. 15, 2005, pages 1525 - 1527
JEONG HJPARK YDPARK HYJEONG IYJEONG TSLEE WS, BIOORG MED CHEM LETT, vol. 16, 2006, pages 5576 - 5579
LIN ECHU YAMANTEA CMPHAM LMCAJICA JOKERBERG EBROWN HEFRASER ADU LKOHNO Y, BIOORG MED CHEM LETT, vol. 22, 2012, pages 868 - 871
NAGANO JMHSU KLWHITBY LRNIPHAKIS MJSPEERS AEBROWN SJSPICER TFERNANDEZ-VEGA VFERGUSON JHODDER P, BIOORG MED CHEM LETT, vol. 23, 2013, pages 1553 - 1556
MAGRIOTI VKOKOTOS G, EXPERT OPIN THER PAT., vol. 23, 2013, pages 333 - 344
DENNIS EACAO JHSU YHMAGRIOTI VKOKOTOS G, CHEM REV., vol. 111, 2011, pages 6130 - 6185
STAFFORINI DMELSTAD MRMCINTYRE TMZIMMERMAN GAPRESCOTT SM, J BIOL CHEM., vol. 265, 1990, pages 9682 - 9687
NAKAJIMA KMURAKAMI MYANOSHITA RSAMEJIMA YKARASAWA KSETAKA MNOJIMA SKUDO I, J BIOL CHEM., vol. 272, 1997, pages 19708 - 19713
CASLAKE MJPACKARD CJSUCKLING KEHOLMES SDCHAMBERLAIN PMACPHEE CH, ATHEROSCLEROSIS, vol. 150, 2000, pages 413 - 419
MACPHEE CHMOORES KEBOYD HFDHANAK DIFE RJLEACH CALEAKE DSMILLINER KJPATTERSON RASUCKLING KE, BIOCHEM J., vol. 338, 1999, pages 479 - 487
QUINN MTPARTHASARATHY SSTEINBERG D, PROC NATL ACAD SCI USA., vol. 85, 1988, pages 2805 - 2809
SHI ET AL., ATHEROSCLEROSIS, vol. 191, 2007, pages 54 - 62
WILENSKY ET AL., CURRENT OPINION IN LIPIDOLOGY, vol. 20, 2009, pages 415 - 420
FITZPATRICK ALIRIZARRY MCCUSHMAN MJENNY NSCHI GCKORO C, ATHEROSCLEROSIS, vol. 235, 2014, pages 384 - 391
STAURENGHI GYE LMAGEE MHDANIS RPWURZELMANN JADAMSON PMCLAUGHLIN MM: "Darapladib DMESG", OPHTHALMOLOGY, vol. 122, 2015, pages 990 - 996
BERTILSSON HTESSEM MBFLATBERG AVISET TGRIBBESTAD IANGELSEN AHALGUNSET J, CLIN CANCER RES., vol. 18, 2012, pages 3261 - 3269
HARDY J ET AL., SCIENCE, vol. 297, 2002, pages 353 - 356
ECHEVERRIA VYARKOV AALIEV G, PROG NEUROBIOL, vol. 144, 2016, pages 142 - 157
CHIANG KKOO EH, ANNU REV PHARMACOL TOXICOL., vol. 54, 2014, pages 381 - 405
AWASTHI MSINGH SPANDEY VPDWIVEDI UN, J NEUROL SCI., vol. 361, 2016, pages 256 - 271
VAN OIJEN ET AL., ANNALS OF NEUROLOGY, vol. 59, 2006, pages 139
MAHER-EDWARDS GDE' ATH JBARNETT CLAVROV ALOCKHART A, ALZHEIMER'S & DEMENTIA: TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, vol. 1, 2015, pages 131 - 140
KASSNER ET AL., CURRENT ALZHEIMER RESEARCH, vol. 5, 2008, pages 358 - 366
DILDAR ET AL., ALZHEIMER DIS ASSOC DISORD, vol. 24, April 2010 (2010-04-01)
SINEM ET AL., CURRENT ALZHEIMER RESEARCH, vol. 7, 2010, pages 463 - 469
COLANGELO ET AL., JOURNAL OF NEUROSCIENCE RESEARCH, vol. 70, 2002, pages 462 - 473
WYSS-CORAY, NATURE MEDICINE, 12 September 2006 (2006-09-12)
BUSCHINI ET AL., PROGRESS IN NEUROBIOLOGY, vol. 95, 2011, pages 14 - 25
TEZEL, PROGRESS IN BRAIN RESEARCH, vol. 173, ISSN: 0079-6123
TEW DGBOYD HFASHMAN STHEOBALD CLEACH CA, BIOCHEMISTRY, vol. 37, 1998, pages 10087 - 10093
JEONG TSKIM MJYU HKIM HSCHOI JKKIM SSLEE WS, BIOORG MED CHEM LETT, vol. 15, 2005, pages 1525 - 1527
JEONG HJPARK YDPARK HYJEONG IYJEONG TSLEE WS, BIOORG MED CHEM LETT, vol. 16, 2006, pages 5576 - 5579
LIN ECHU YAMANTEA CMPHAM LMCAJICA JOKERBERG EBROWN HEFRASER ADU LKOHNO Y, BIOORG MED CHEM LETT, vol. 22, 2012, pages 868 - 871
NAGANO JMHSU KLWHITBY LRNIPHAKIS MJSPEERS AEBROWN SJSPICER TFERNANDEZ-VEGA VFERGUSON JHODDER P, BIOORG MED CHEM LETT, vol. 23, 2013, pages 1553 - 1556
MAGRIOTI VKOKOTOS G, EXPERT OPIN THER PAT., vol. 23, 2013, pages 333 - 344
Attorney, Agent or Firm:
BEIJING TANLULAI PATENT AGENT LTD (CN)
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