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Patent Searching and Data


Title:
TETRAZINES FOR HIGH CLICK CONJUGATION YIELD IN VIVO AND HIGH CLICK RELEASE YIELD
Document Type and Number:
WIPO Patent Application WO/2019/212356
Kind Code:
A8
Abstract:
Disclosed herein are tetrazines substituted with groups that result in a high click conjugation yield in vivo and high click release yields. In one aspect, the invention relates to kits comprising said tetrazines and a dienophile, preferably a trans-cyclooctene. In another aspect, the kits of the invention are for use as a medicament.

Inventors:
ROBILLARD MARC STEFAN (NL)
VERSTEEGEN RONNY MATHIEU (NL)
ROSSIN RAFFAELLA (NL)
HOEBEN FREEK JOHANNES MARIA (NL)
VAN KASTEREN SANDER IZAAK (NL)
VAN DE GRAAFF MICHEL JOHAN (NL)
Application Number:
PCT/NL2019/050271
Publication Date:
November 12, 2020
Filing Date:
May 06, 2019
Export Citation:
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Assignee:
TAGWORKS PHARMACEUTICALS B V (NL)
International Classes:
A61K47/68; A61K51/04; A61P35/00; C07D257/08
Attorney, Agent or Firm:
WITMANS, H.A. (NL)
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