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Title:
THERAPEUTIC AGENT FOR ARTICULAR RHEUMATISM
Document Type and Number:
WIPO Patent Application WO/1998/051315
Kind Code:
A1
Abstract:
An articular rheumatism remedy which is an asialotrisaccharic moranoline derivative represented by general formula [I] or a pharmacologically acceptable salt thereof, wherein -A- represents -(CH�2?)�m?-, -(CH�2?)�n?-NR?e�-CO-O-, -CO-O-, -(CH�2?)�n?-CO-O-, or -(CH�2?)�n?-O- (wherein R?e� represents hydrogen or lower alkyl; m is an integer of 0 to 12; and n is an integer of 2 to 12); R represents formulae (A) or (B) wherein R?a� and R?b� may be the same or different and each represents an (un)saturated aliphatic hydrocarbon group or an (un)saturated acyl; and one of R?1� and R?2� represents either galactopyranosyl in which optionally all or part of the hydrogen atoms of the hydroxyl groups have been replaced with any of formulae (C) and (D) and the other represents fucopyranosyl, provided that R?c� and R?d� may be the same or different and each represents alkyl or hydroxy.

Inventors:
EZURE YOJI (JP)
MARUO SHIGEAKI (JP)
OGAWA HIROTSUGU (JP)
Application Number:
PCT/JP1998/002061
Publication Date:
November 19, 1998
Filing Date:
May 08, 1998
Export Citation:
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Assignee:
NIPPON SHINYAKU CO LTD (JP)
EZURE YOJI (JP)
MARUO SHIGEAKI (JP)
OGAWA HIROTSUGU (JP)
International Classes:
A61K31/70; C07H17/02; (IPC1-7): A61K31/70
Domestic Patent References:
WO1997048712A11997-12-24
WO1997002278A11997-01-23
WO1997000881A11997-01-09
WO1995026970A11995-10-12
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