Title:
THERAPEUTIC AGENT FOR NERVE DISORDERS
Document Type and Number:
WIPO Patent Application WO/2022/114216
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a therapeutic agent that is more efficacious for treating nerve disorders, said therapeutic agent comprising a culture supernatant of mesenchymal stem cells. The present invention provides a therapeutic agent for nerve disorders, said therapeutic agent comprising a culture supernatant of mesenchymal stem cells and/or cells capable of differentiating into mesenchymal stem cells and being to be used together with stimulation of patient's nerves, wherein the stimulation is preferentially provided to one or more sites selected from the group consisting of a site of nerve damage, an area surrounding a site of nerve damage, and a site compensating for the function of a site of nerve damage.
Inventors:
KIHOIN NAGATOSHI (JP)
OKADA KUNIHIKO (JP)
OKADA KUNIHIKO (JP)
Application Number:
PCT/JP2021/043813
Publication Date:
June 02, 2022
Filing Date:
November 30, 2021
Export Citation:
Assignee:
NEUROTECH MEDICAL CO LTD (JP)
International Classes:
A61K35/28; A61K9/19; A61P25/00; A61P43/00
Domestic Patent References:
| WO2017188457A1 | 2017-11-02 | |||
| WO2009002503A1 | 2008-12-31 |
Foreign References:
| JP2019527218A | 2019-09-26 | |||
| JP2016065106A | 2016-04-28 | |||
| JP2008137954A | 2008-06-19 | |||
| JP2013508013A | 2013-03-07 | |||
| JP4061487B2 | 2008-03-19 |
Other References:
LEE JI YONG; KIM HYUN SOO; KIM SUNG HOON; KIM HAN-SOO; CHO BYUNG PIL: "Combination of Human Mesenchymal Stem Cells and Repetitive Transcranial Magnetic Stimulation Enhances Neurological Recovery of 6-Hydroxydopamine Model of Parkinsonian’s Disease", TISSUE ENGINEERING AND REGENERATIVE MEDICINE, SPRINGER SINGAPORE, SINGAPORE, vol. 17, no. 1, 22 January 2020 (2020-01-22), Singapore, pages 67 - 80, XP037003004, ISSN: 1738-2696, DOI: 10.1007/s13770-019-00233-8
YUSUKE SAKIYAMA, HIROSHI TAKASHIMA : "Advances in the treatment of spinocerebellar degeneration ", NEUROLOGICAL THERAPEUTICS = SHINKEI CHIRYO, JP, vol. 36, no. 5, 1 January 2018 (2018-01-01), JP , pages 580 - 583, XP055934302, ISSN: 0916-8443
BUCAN VESNA; VASLAITIS DESIREE; PECK CLAAS-TIDO; STRAUß SARAH; VOGT PETER M.; RADTKE CHRISTINE: "Effect of Exosomes from Rat Adipose-Derived Mesenchymal Stem Cells on Neurite Outgrowth and Sciatic Nerve Regeneration After Crush Injury", MOLECULAR NEUROBIOLOGY, SPRINGER US, NEW YORK, vol. 56, no. 3, 21 June 2018 (2018-06-21), New York, pages 1812 - 1824, XP036714187, ISSN: 0893-7648, DOI: 10.1007/s12035-018-1172-z
MORETTI DAVIDE VITO: "Available and future treatments for atypical parkinsonism. A systematic review", CNS NEUROSCIENCE & THERAPEUTICS, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 25, no. 2, 1 February 2019 (2019-02-01), GB , pages 159 - 174, XP055934093, ISSN: 1755-5930, DOI: 10.1111/cns.13068
CHOI YUN-KYONG, URNUKHSAIKHAN ENERELT, YOON HEE-HOON, SEO YOUNG-KWON, CHO HYUNJIN, JEONG JONG-SEOB, KIM SOO-CHAN, PARK JUNG-KEUG: "Combined effect of pulsed electromagnetic field and sound wave on In vitro and In vivo neural differentiation of human mesenchymal stem cells", BIOTECHNOLOGY PROGRESS, AMERICAN CHEMICAL SOCIETY, vol. 33, no. 1, 1 January 2017 (2017-01-01), pages 201 - 211, XP055934099, ISSN: 8756-7938, DOI: 10.1002/btpr.2389
CHOI YUN-KYONG; CHO HYUNJIN; SEO YOUNG-KWON; YOON HEE-HOON; PARK JUNG-KEUG: "Stimulation of sub-sonic vibration promotes the differentiation of adipose tissue-derived mesenchymal stem cells into neural cells", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 91, no. 9, 1 January 1900 (1900-01-01), GB , pages 329 - 337, XP028936413, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2012.07.022
YUSUKE SAKIYAMA, HIROSHI TAKASHIMA : "Advances in the treatment of spinocerebellar degeneration ", NEUROLOGICAL THERAPEUTICS = SHINKEI CHIRYO, JP, vol. 36, no. 5, 1 January 2018 (2018-01-01), JP , pages 580 - 583, XP055934302, ISSN: 0916-8443
BUCAN VESNA; VASLAITIS DESIREE; PECK CLAAS-TIDO; STRAUß SARAH; VOGT PETER M.; RADTKE CHRISTINE: "Effect of Exosomes from Rat Adipose-Derived Mesenchymal Stem Cells on Neurite Outgrowth and Sciatic Nerve Regeneration After Crush Injury", MOLECULAR NEUROBIOLOGY, SPRINGER US, NEW YORK, vol. 56, no. 3, 21 June 2018 (2018-06-21), New York, pages 1812 - 1824, XP036714187, ISSN: 0893-7648, DOI: 10.1007/s12035-018-1172-z
MORETTI DAVIDE VITO: "Available and future treatments for atypical parkinsonism. A systematic review", CNS NEUROSCIENCE & THERAPEUTICS, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 25, no. 2, 1 February 2019 (2019-02-01), GB , pages 159 - 174, XP055934093, ISSN: 1755-5930, DOI: 10.1111/cns.13068
CHOI YUN-KYONG, URNUKHSAIKHAN ENERELT, YOON HEE-HOON, SEO YOUNG-KWON, CHO HYUNJIN, JEONG JONG-SEOB, KIM SOO-CHAN, PARK JUNG-KEUG: "Combined effect of pulsed electromagnetic field and sound wave on In vitro and In vivo neural differentiation of human mesenchymal stem cells", BIOTECHNOLOGY PROGRESS, AMERICAN CHEMICAL SOCIETY, vol. 33, no. 1, 1 January 2017 (2017-01-01), pages 201 - 211, XP055934099, ISSN: 8756-7938, DOI: 10.1002/btpr.2389
CHOI YUN-KYONG; CHO HYUNJIN; SEO YOUNG-KWON; YOON HEE-HOON; PARK JUNG-KEUG: "Stimulation of sub-sonic vibration promotes the differentiation of adipose tissue-derived mesenchymal stem cells into neural cells", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 91, no. 9, 1 January 1900 (1900-01-01), GB , pages 329 - 337, XP028936413, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2012.07.022
Attorney, Agent or Firm:
NIIYAMA Yuichi et al. (JP)
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