Title:
THERAPEUTIC COMPOSITIONS AND METHODS OF USING SEROTONIN MODULATING MICROBIOME-BASED INTERVENTIONS TO TREAT SEROTONIN-RELATED DISEASES OR DISORDERS
Document Type and Number:
WIPO Patent Application WO/2020/264390
Kind Code:
A3
Abstract:
The technology described herein is directed to compositions and methods for modulating serotonin in a subject. Described herein are compositions comprising viable or non-viable serotoninmodulating bacteria, conditioned medium(s) of serotonin-modulating bacteria, cell pellet(s) of serotoninmodulating bacteria, and/or metabolites and/or proteins derived from serotonin-modulating bacteria. Also described herein are methods of treating serotonin-related disease or disorders.
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Inventors:
STRANDWITZ PHILIP (US)
CABONI MARIAELENA (US)
SKOLNICK STEPHEN (US)
CABONI MARIAELENA (US)
SKOLNICK STEPHEN (US)
Application Number:
PCT/US2020/039947
Publication Date:
April 08, 2021
Filing Date:
June 26, 2020
Export Citation:
Assignee:
HOLOBIOME INC (US)
International Classes:
A61K35/741; A23L33/135; A23L33/14; A61K31/505; A61K35/742; A61K35/747; A61K36/06; A61P25/00
Domestic Patent References:
| WO2019070913A1 | 2019-04-11 | |||
| WO2018187272A1 | 2018-10-11 | |||
| WO2020160183A1 | 2020-08-06 |
Foreign References:
| US20160058808A1 | 2016-03-03 |
Other References:
D'AURIA G ET AL.: "Complete Genome Sequence of Acidaminococcus intestini RYC-MR95, a Gram-Negative Bacterium from the Phylum Firmicutes", JOURNAL OF BACTERIOLOGY, vol. 193, no. 24, 15 December 2011 (2011-12-15), pages 7008 - 7009, XP055811554, DOI: 10.1128/JB.06301-11
LOPEZ-MEYER, M ET AL.: "Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminate which are differentially expressed during development and stress", THE PLANT JOURNAL, vol. 11, no. 6, 1997, pages 1167 - 1175, XP002950162, DOI: 10.1046/j.1365-313x.1997.11061167.x
LOPEZ-MEYER, M ET AL.: "Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminate which are differentially expressed during development and stress", THE PLANT JOURNAL, vol. 11, no. 6, 1997, pages 1167 - 1175, XP002950162, DOI: 10.1046/j.1365-313x.1997.11061167.x
Attorney, Agent or Firm:
FITZGERALD, Mark J. et al. (US)
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