Title:
THERAPEUTIC OR PROPHYLACTIC AGENT FOR CHRONIC KIDNEY DISEASE CONTAINING PYRAZOLE-AMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/054734
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel pharmaceutical use of a compound A, a pharmaceutically acceptable salt thereof or a monohydrate of the compound A. The present invention relates to a therapeutic or prophylactic agent for chronic kidney disease, which contains a compound A, a pharmaceutically acceptable salt thereof or a monohydrate of the compound A as an active ingredient.
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Inventors:
SAITO TOMOYUKI (JP)
OHTA TAKESHI (JP)
KAKUTANI MAKOTO (JP)
MERA YASUKO (JP)
OHTA TAKESHI (JP)
KAKUTANI MAKOTO (JP)
MERA YASUKO (JP)
Application Number:
PCT/JP2019/035586
Publication Date:
March 19, 2020
Filing Date:
September 10, 2019
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
International Classes:
A61K31/415; A61P13/12
Domestic Patent References:
| WO2014142290A1 | 2014-09-18 | |||
| WO2018021508A1 | 2018-02-01 | |||
| WO2010041748A1 | 2010-04-15 | |||
| WO2014142290A1 | 2014-09-18 | |||
| WO2018021508A1 | 2018-02-01 | |||
| WO2019151274A1 | 2019-08-08 |
Foreign References:
| JPH01242523A | 1989-09-27 |
Other References:
TAMAKI, MASANORI ET AL.: "Chronic kidney disease reduces muscle mitochondria and exercise endurance and its exacerbation by dietary protein through inactivation of pyruvate dehydrogenase", KIDNEY INTERNATIONAL, vol. 85, no. 6, June 2014 (2014-06-01), pages 1330 - 1339, XP055693091
KATO, MASATO ET AL.: "Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545", DICHLOROACETATE, AND RADICICOL, STRUCTURE, vol. 15, no. 8, August 2007 (2007-08-01), pages 992 - 1004, XP022192478, DOI: 10.1016/j.str.2007.07.001
MIYASHITA, KAZUTOSHI ET AL.: "Elucidation of the mechanism of tubulo-interstitial injury in chronic kidney disease by use of newly developed chronic renal ischemia model", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 30, no. 3, 21 May 2015 (2015-05-21), pages iii404, XP009527138, ISSN: 0931-0509
KATSUDAYOSHIAKI ET AL.: "Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rat, a novel obese type 2 diabetic model", ANIMAL SCIENCE JOURNAL, vol. 85, no. 5, 2014, pages 588 - 594
TSUPRYKOVOLEG ET AL.: "The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5/6 nephrectomy", KIDNEY INTERNATIONAL, vol. 89, no. 5, 2016, pages 1049 - 1061
BERGE ET AL., J. PHARM. SCI., vol. 66, 1977
STAHL ET AL.: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
PAULEKUHN ET AL., J. MED. CHEM., vol. 50, 2007, pages 6665 - 6672
"Chronic Kidney Disease", MERCK MANUAL PROFESSIONAL VERSION, October 2018 (2018-10-01), Retrieved from the Internet
KIDNEY INT SUPPL, vol. 2, 2012, pages 363 - 369
AM J KIDNEY DIS, vol. 62, 2013, pages 201 - 213
NEPHOL DIAL TRANSPLANT, vol. 29, 2014, pages 490 - 496
LANCET, vol. 385, 2015, pages 2047 - 2056
See also references of EP 3851103A4
KATO, MASATO ET AL.: "Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545", DICHLOROACETATE, AND RADICICOL, STRUCTURE, vol. 15, no. 8, August 2007 (2007-08-01), pages 992 - 1004, XP022192478, DOI: 10.1016/j.str.2007.07.001
MIYASHITA, KAZUTOSHI ET AL.: "Elucidation of the mechanism of tubulo-interstitial injury in chronic kidney disease by use of newly developed chronic renal ischemia model", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 30, no. 3, 21 May 2015 (2015-05-21), pages iii404, XP009527138, ISSN: 0931-0509
KATSUDAYOSHIAKI ET AL.: "Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rat, a novel obese type 2 diabetic model", ANIMAL SCIENCE JOURNAL, vol. 85, no. 5, 2014, pages 588 - 594
TSUPRYKOVOLEG ET AL.: "The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5/6 nephrectomy", KIDNEY INTERNATIONAL, vol. 89, no. 5, 2016, pages 1049 - 1061
BERGE ET AL., J. PHARM. SCI., vol. 66, 1977
STAHL ET AL.: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
PAULEKUHN ET AL., J. MED. CHEM., vol. 50, 2007, pages 6665 - 6672
"Chronic Kidney Disease", MERCK MANUAL PROFESSIONAL VERSION, October 2018 (2018-10-01), Retrieved from the Internet
KIDNEY INT SUPPL, vol. 2, 2012, pages 363 - 369
AM J KIDNEY DIS, vol. 62, 2013, pages 201 - 213
NEPHOL DIAL TRANSPLANT, vol. 29, 2014, pages 490 - 496
LANCET, vol. 385, 2015, pages 2047 - 2056
See also references of EP 3851103A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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