Title:
THERAPY FOR INTERSTITIAL CYSTITIS BY PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2021/085639
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel medical application using pluripotent stem cells in regenerative medicine. The present invention provides a cell formulation and pharmaceutical composition that are for amelioration and therapy for frequent urination and bladder pain caused by the inflammation of the bladder and that contain SSEA-3 positive pluripotent stem cells isolated from cultured mesenchymal cells or a mesenchymal tissue of a living organism. The cell formulation according to the present invention is considered to be based on a mechanism in which, for example, Muse cells are administered against interstitial cystitis having the abovementioned disorders to be successfully engrafted into affected bladder tissue, whereby the disorders are ameliorated and treated.
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Inventors:
YAMAMOTO TOKUNORI (JP)
SHIMIZU SHINOBU (JP)
FURUTA AKIRA (JP)
DEZAWA MARI (JP)
KURODA YASUMASA (JP)
SHIMIZU SHINOBU (JP)
FURUTA AKIRA (JP)
DEZAWA MARI (JP)
KURODA YASUMASA (JP)
Application Number:
PCT/JP2020/040963
Publication Date:
May 06, 2021
Filing Date:
October 30, 2020
Export Citation:
Assignee:
LIFE SCIENCE INST INC (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
THE JIKEI UNIV (JP)
UNIV TOHOKU (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
THE JIKEI UNIV (JP)
UNIV TOHOKU (JP)
International Classes:
A61K35/545; A61K35/28; A61P13/10; A61P43/00; C12N5/0775
Domestic Patent References:
| WO2014027474A1 | 2014-02-20 | |||
| WO2011007900A1 | 2011-01-20 |
Foreign References:
| JP2016008198A | 2016-01-18 | |||
| JP2015160820A | 2015-09-07 | |||
| JP2012139246A | 2012-07-26 | |||
| JP4183742B1 | 2008-11-19 |
Other References:
FURUTA, A ET AL.: "Bladder wall injection of mesenchymal stem cells ameliorates bladder inflammation, overactivity, and nociception in a chemically induced interstitial cystitis-like rat model", INTERNATIONAL UROGYNECOLOGY JOURNAL, vol. 29, 2018, pages 1615 - 1622, XP036768584, DOI: 10.1007/s00192-018-3592-8
HIROSE YUJIRO, YAMAMOTO TOKUNORI, NAKASHIMA MISAKO, FUNAHASHI YASUHITO, MATSUKAWA YOSHIHISA, YAMAGUCHI MASAYA, KAWABATA SHIGETADA,: "Injection of Dental Pulp Stem Cells Promotes Healing of Damaged Bladder Tissue in a Rat Model of Chemically Induced Cystitis", CELL TRANSPLANTATION, SAGE, US, vol. 25, no. 3, 1 March 2016 (2016-03-01), US , pages 425 - 436, XP055932317, ISSN: 0963-6897, DOI: 10.3727/096368915X689523
DEZAWA MARI: "A novel type of human pluripotent stem cells, Muse cells; that reside in mesenchymal tissues their possibility of application to neural regeneration", PERIPHERAL NERVE, vol. 23, no. 2, 30 November 2011 (2011-11-30), JAPAN , pages 135 - 139, XP009537079, ISSN: 0917-6772
LANDER ELLIOT B., BERMAN MARK H., SEE JACKIE R.: "Personal cell therapy for interstitial cystitis with autologous stromal vascular fraction stem cells", THERAPEUTIC ADVANCES IN UROLOGY, SAGE PUBLICATIONS LTD., GB, vol. 11, 1 January 2019 (2019-01-01), GB , pages 175628721986859, XP055932319, ISSN: 1756-2872, DOI: 10.1177/1756287219868590
XIE JUNCONG, LIU BOLONG, CHEN JIALIANG, XU YUANCHENG, ZHAN HAILUN, YANG FEI, LI WENBIAO, ZHOU XIANGFU: "Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 495, no. 1, 1 January 2018 (2018-01-01), Amsterdam NL , pages 546 - 552, XP055932321, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2017.11.072
KIM, B. S. ET AL.: "Efficacy of combination therapy with pentosan polysulfate sodium and adipose tissue-derived stem cells for the management of interstitial cystitis in a rat model", STEM CELL RESEARCH, vol. 45, no. 101801, 21 April 2020 (2020-04-21), pages 1 - 7, XP086164993, Retrieved from the Internet DOI: 10.1016/j.scr.2020.101801
FURUTA, AKIRA: "The usefulness of human Muse cell transplantation for an interstitial cystitis-like rat model", JOURNAL OF INTERSTITIAL CYSTITIS, vol. 15, no. 1, 27 December 2019 (2019-12-27), JP, pages 13, XP009536693
VAN DER MERVE ET AL., EUROPEAN UROLOGY, vol. 53, 2008, pages 60 - 67
MACDIARMID SA ET AL., REV UROL, vol. 9, no. 1, 2007, pages 9 - 16
"Medical treatment guidelines for interstitial cystitis and bladder pain syndrome", 2019, RICHHILL MEDICAL INC.
OGURA, F. ET AL., STEM CELLS DEV, 20 November 2013 (2013-11-20)
HIROSE YUJIRO, YAMAMOTO TOKUNORI, NAKASHIMA MISAKO, FUNAHASHI YASUHITO, MATSUKAWA YOSHIHISA, YAMAGUCHI MASAYA, KAWABATA SHIGETADA,: "Injection of Dental Pulp Stem Cells Promotes Healing of Damaged Bladder Tissue in a Rat Model of Chemically Induced Cystitis", CELL TRANSPLANTATION, SAGE, US, vol. 25, no. 3, 1 March 2016 (2016-03-01), US , pages 425 - 436, XP055932317, ISSN: 0963-6897, DOI: 10.3727/096368915X689523
DEZAWA MARI: "A novel type of human pluripotent stem cells, Muse cells; that reside in mesenchymal tissues their possibility of application to neural regeneration", PERIPHERAL NERVE, vol. 23, no. 2, 30 November 2011 (2011-11-30), JAPAN , pages 135 - 139, XP009537079, ISSN: 0917-6772
LANDER ELLIOT B., BERMAN MARK H., SEE JACKIE R.: "Personal cell therapy for interstitial cystitis with autologous stromal vascular fraction stem cells", THERAPEUTIC ADVANCES IN UROLOGY, SAGE PUBLICATIONS LTD., GB, vol. 11, 1 January 2019 (2019-01-01), GB , pages 175628721986859, XP055932319, ISSN: 1756-2872, DOI: 10.1177/1756287219868590
XIE JUNCONG, LIU BOLONG, CHEN JIALIANG, XU YUANCHENG, ZHAN HAILUN, YANG FEI, LI WENBIAO, ZHOU XIANGFU: "Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 495, no. 1, 1 January 2018 (2018-01-01), Amsterdam NL , pages 546 - 552, XP055932321, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2017.11.072
KIM, B. S. ET AL.: "Efficacy of combination therapy with pentosan polysulfate sodium and adipose tissue-derived stem cells for the management of interstitial cystitis in a rat model", STEM CELL RESEARCH, vol. 45, no. 101801, 21 April 2020 (2020-04-21), pages 1 - 7, XP086164993, Retrieved from the Internet
FURUTA, AKIRA: "The usefulness of human Muse cell transplantation for an interstitial cystitis-like rat model", JOURNAL OF INTERSTITIAL CYSTITIS, vol. 15, no. 1, 27 December 2019 (2019-12-27), JP, pages 13, XP009536693
VAN DER MERVE ET AL., EUROPEAN UROLOGY, vol. 53, 2008, pages 60 - 67
MACDIARMID SA ET AL., REV UROL, vol. 9, no. 1, 2007, pages 9 - 16
"Medical treatment guidelines for interstitial cystitis and bladder pain syndrome", 2019, RICHHILL MEDICAL INC.
OGURA, F. ET AL., STEM CELLS DEV, 20 November 2013 (2013-11-20)
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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