Title:
THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2016/068341
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a compound and a pharmaceutical composition that exhibit superior efficacy against tumors, especially tumors that have acquired gemcitabine resistance. The present invention provides thionucleoside derivatives represented by general formula (1), or salts thereof. (In the formula: R1 represents an optionally protected hydroxyl group, an optionally substituted C1-20 alkoxy group, or the like; R2 represents an optionally substituted C1-20 alkoxy group, an optionally substituted C3-8 cycloalkoxy group, or the like; and R3 represents a hydrogen atom or the like). Further provided are pharmaceutical compositions containing these thionucleoside derivatives or salts thereof.
Inventors:
KUNIYOSHI HIDENOBU (JP)
NAKAGAWA DAISUKE (JP)
MATSUMOTO TAKUYA (JP)
YOSHIMITSU YUJI (JP)
NAKAGAWA DAISUKE (JP)
MATSUMOTO TAKUYA (JP)
YOSHIMITSU YUJI (JP)
Application Number:
PCT/JP2015/080885
Publication Date:
May 06, 2016
Filing Date:
November 02, 2015
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C07H19/10; A61K31/7068; A61P35/00; A61P35/02
Domestic Patent References:
| WO1997038001A1 | 1997-10-16 | |||
| WO2007056596A2 | 2007-05-18 |
Foreign References:
| JP2006528162A | 2006-12-14 | |||
| JP2013540129A | 2013-10-31 | |||
| JP2013537907A | 2013-10-07 |
Other References:
SLUSARCZYK,M. ET AL.: "Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 4, 28 January 2014 (2014-01-28), pages 1531 - 1542, XP055205033, ISSN: 0022-2623, DOI: doi:10.1021/jm401853a
See also references of EP 3214090A4
See also references of EP 3214090A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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