Title:
THYMINE NUCLEOBASE-BASED TRIAZOLOPYRIMIDINES AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/204024
Kind Code:
A1
Abstract:
Provided are: novel triazolopyrimidines that can be induced from the nucleobase thymine; a production method for the triazolopyrimidines; and various physiologically active substances, particularly an antitumor agent, obtained by the method. These triazolopyrimidine compounds are represented by formulas (I)-(VIII) (in the formulas, R represents a hydrogen atom, an alkyl group, or an aryl group). This production method produces the triazolopyrimidine compounds.
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Inventors:
NAGAMATSU TOMOHISA (JP)
Application Number:
PCT/JP2020/014810
Publication Date:
October 08, 2020
Filing Date:
March 31, 2020
Export Citation:
Assignee:
TERA STONE CO LTD (JP)
International Classes:
A61P35/00; A61K31/519; C07D487/04
Domestic Patent References:
| WO2006132275A1 | 2006-12-14 |
Foreign References:
| JPS59167592A | 1984-09-21 | |||
| JP2002037787A | 2002-02-06 | |||
| JPS62135475A | 1987-06-18 | |||
| JPH01500996A | 1989-04-06 | |||
| JPS5632479A | 1981-04-01 | |||
| JP2019071525A | 2019-05-09 |
Other References:
NAGAMATSU T. ET AL.: "The First Reliable, General Synthesis of the 5-0xo Derivatives of 5, 6-Dihydro-1, 2,4-triazolo[4,3-c]pyrimidine and the Rates of Isomerization of the [4,3-c] Compounds into Their [1,5-c] Isomers", HETEROCYCLES, vol. 57, no. 4, 2002, pages 631 - 636, XP055368222, DOI: 10.3987/COM-02-9450
DATABASE REGISTRY 19 June 2016 (2016-06-19), "C6 H9 N O3 . Li", XP055747631, retrieved from STN Database accession no. 1934600-89-1
DATABASE REGISTRY 15 April 2012 (2012-04-15), "-C6 H5 Br N4 O SR -Chemical Catalog Supplier: Otava Chemicals LC -STN Files: CHEMCATS", XP055747637, retrieved from STN Database accession no. 1367943-51-8
ANONYMOUS: "pocl3 246trichloropyridine.png", 9 November 2015 (2015-11-09), XP009531228, Retrieved from the Internet [retrieved on 20200612]
D. J. BROWNT. NAGAMATSU ET AL., AUST. J. CHEM., vol. 31, 1978, pages 2505 - 404
D. J. BROWNT. NAGAMATSU ET AL., AUST. J. CHEM., vol. 32, 1979, pages 2713 - 26
T. NAGAMATSU ET AL., HETEROCYCLES, vol. 57, no. 4, 2002, pages 631 - 636
R. N. CASTLE ET AL., J. HETEROCYCL. CHEM., vol. 3, 1966, pages 79
V. UCHYTILOVA ET AL., COLLECTION OF CZECHOSLOVAK CHEM. COMMUNICATIONS, vol. 40, no. 8, 1975, pages 2347
H. C. KOPPEL ET AL., J. ORG. CHEM., vol. 27, 1962, pages 181
T. MOSMANN, J. IMMUNOL. METHODS, vol. 65, 1983, pages 55
M. B. HANSENS. E. NIELSENK. BERG, J. IMMUNOL. METHODS, vol. 119, 1989, pages 203
See also references of EP 3950064A4
DATABASE REGISTRY 19 June 2016 (2016-06-19), "C6 H9 N O3 . Li", XP055747631, retrieved from STN Database accession no. 1934600-89-1
DATABASE REGISTRY 15 April 2012 (2012-04-15), "-C6 H5 Br N4 O SR -Chemical Catalog Supplier: Otava Chemicals LC -STN Files: CHEMCATS", XP055747637, retrieved from STN Database accession no. 1367943-51-8
ANONYMOUS: "pocl3 246trichloropyridine.png", 9 November 2015 (2015-11-09), XP009531228, Retrieved from the Internet
D. J. BROWNT. NAGAMATSU ET AL., AUST. J. CHEM., vol. 31, 1978, pages 2505 - 404
D. J. BROWNT. NAGAMATSU ET AL., AUST. J. CHEM., vol. 32, 1979, pages 2713 - 26
T. NAGAMATSU ET AL., HETEROCYCLES, vol. 57, no. 4, 2002, pages 631 - 636
R. N. CASTLE ET AL., J. HETEROCYCL. CHEM., vol. 3, 1966, pages 79
V. UCHYTILOVA ET AL., COLLECTION OF CZECHOSLOVAK CHEM. COMMUNICATIONS, vol. 40, no. 8, 1975, pages 2347
H. C. KOPPEL ET AL., J. ORG. CHEM., vol. 27, 1962, pages 181
T. MOSMANN, J. IMMUNOL. METHODS, vol. 65, 1983, pages 55
M. B. HANSENS. E. NIELSENK. BERG, J. IMMUNOL. METHODS, vol. 119, 1989, pages 203
See also references of EP 3950064A4
Attorney, Agent or Firm:
MORIMOTO, Toshiaki (JP)
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