Title:
TLR8 AGONIST
Document Type and Number:
WIPO Patent Application WO/2020/078455
Kind Code:
A1
Abstract:
The present invention relates to a structurally novel TLR8 (Toll-like receptor 8) agonist and, in particular, to a compound thereof of formula (I), a pharmaceutically acceptable salt and an isomer thereof.
Inventors:
SUN FEI (CN)
CAI ZHE (CN)
DING CHARLES Z (CN)
CHEN SHUHUI (CN)
CAI ZHE (CN)
DING CHARLES Z (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2019/111897
Publication Date:
April 23, 2020
Filing Date:
October 18, 2019
Export Citation:
Assignee:
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D239/95; A61K31/517; A61P31/00; A61P31/14; A61P31/18; A61P31/20; C07D401/12; C07D413/04; C07D413/14; C07D475/04
Domestic Patent References:
| WO2018107200A1 | 2018-06-21 |
Foreign References:
| US9663474B2 | 2017-05-30 | |||
| CN201811221301A | 2018-10-19 | |||
| CN201910161144A | 2019-03-04 |
Other References:
SOLOMON, V.R. ET AL.: "Design, Synthesis of 4-Aminoquinoline-Derived Thiazolidines and Their Antimalarial Activity and Heme Polymerization Inhibition Studies", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 28, no. 3, June 2013 (2013-06-01), pages 619 - 626, XP055702863, ISSN: 1475-6366
STILL, W. C.KAHN, M.MITRA, M., JOURNAL OF ORGANIC CHEMISTRY, vol. 43, 1978, pages 2923 - 2925
See also references of EP 3875451A4
STILL, W. C.KAHN, M.MITRA, M., JOURNAL OF ORGANIC CHEMISTRY, vol. 43, 1978, pages 2923 - 2925
See also references of EP 3875451A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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