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Title:
TOPICAL ADMINISTRATION OF 2- (DIETHYLAMINO) ETHYL 2- (4-ISOBUTYLPHENYL) PROPIONATE FOR TREATMENT OF DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/244637
Kind Code:
A1
Abstract:
Provided herein is 2-(diethylamino) ethyl 2-(4-isobutylphenyl) propionate or pharmaceutically acceptable salts thereof. Furthermore, for use and methods in the treatment of various pains and inflammation, in particular osteoarthritis with pharmaceutical compositions, treatment kits and devices comprising 2-(diethylamino) ethyl 2-(4-isobutylphenyl) propionate and/or pharmaceutically acceptable salts thereof, as well as dosage forms, dosages, and methods of use thereof through topical administration, for treatment of various pains and inflammation, in particular osteoarthritis, are disclosed.

Inventors:
YU CHONGXI (US)
XU LINA (CN)
Application Number:
PCT/CN2021/098323
Publication Date:
December 09, 2021
Filing Date:
June 04, 2021
Export Citation:
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Assignee:
YU CHONGXI (US)
TECHFIELDS PHARMA CO LTD (CN)
International Classes:
A61K9/12; C07C219/10; A61K9/70; A61K31/216; A61P19/02; A61P29/00; C07C211/63; C07C213/06
Domestic Patent References:
WO2008010025A12008-01-24
Foreign References:
US20140256749A12014-09-11
CN108727206A2018-11-02
CN105143174A2015-12-09
CN103948571A2014-07-30
CN101822841A2010-09-08
US9872846B22018-01-23
Other References:
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HALEN, PARMESHWARI K. ET AL.: "Combining Anticholinergic and Anti-inflammatory Activities into a Single Moiety: A Novel Approach to Reduce Gastrointestinal Toxicity of Ibuprofen and Ketoprofen", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 70, no. 5, 31 December 2007 (2007-12-31), pages 450 - 455, XP055471119, DOI: 10.1111/j.1747-0285.2007.00574.x
WILLIAM G. BENSENJUSTUS J. FIECHTNERJAMES I. MCMILLEN: "Treatment of Osteoarthritis with Celecoxib", MAYO CLIN PROC, vol. 74, November 1999 (1999-11-01), pages 1095 - 1105, XP009536237, DOI: 10.4065/74.11.1095
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T. J. SCHNITZERA. KIVITZH. FRAYSSINETB. DUQUESROIX: "Efficacy and safety of naproxcinod in the treatment of patients with osteoarthritis of the knee: a 13-week prospective, randomized, multicenter study", OSTEOARTHRITIS AND CARTILAGE, vol. 18, no. 5, 2010, pages 629 - 639, XP027026838
AMY E. BIYANDCLIFFORD R. BAYERMICHAEL J. ALDAPEDENNIS L. STEVENS: "The roles of injury and nonsteroidal anti-inflammatory drugs in the development and out comes of severe group A streptococcal soft tissue infections", CURR. OPIN. INFECT DIS., vol. 28, no. 3, June 2015 (2015-06-01), pages 231 - 239
GUILLAUME VOIRIOTQUENTIN PHILIPPOTALEXANDRE ELABBADICAROLE ELBIMMARTIN CHALUMEAUMURIEL FARTOUKH: "Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in Community-Acquired Pneumonia in Adult and Pediatric Patients", J. CLIN. MED., vol. 8, 2019, pages 786 - 795
Attorney, Agent or Firm:
BEIJING WANHUIDA LAW FIRM (CN)
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