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Title:
TREATMENT OF INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IRS2 AND TRANSCRIPTION FACTOR E3 (TFE3)
Document Type and Number:
WIPO Patent Application WO/2011/082281
Kind Code:
A3
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Insulin Receptor Substrate 2 (IRS2) polynucleotides, in particular, by targeting natural antisense polynucleotides of Insulin Receptor Substrate 2 (IRS2) polynucleotides and Transcription factor E3 (TFE3). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IRS2.

Inventors:
COLLARD JOSEPH (US)
KHORKOVA SHERMAN OLGA (US)
Application Number:
PCT/US2010/062463
Publication Date:
April 12, 2012
Filing Date:
December 30, 2010
Export Citation:
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Assignee:
OPKO CURNA LLC (US)
COLLARD JOSEPH (US)
KHORKOVA SHERMAN OLGA (US)
International Classes:
C12N15/113; A61K31/7088; A61K48/00; C12N15/63
Domestic Patent References:
WO2006127976A22006-11-30
Foreign References:
US20070264631A12007-11-15
US20070178087A12007-08-02
Other References:
VERMA ET AL.: "Modified oligonucleotides: synthesis and strategy for users.", ANNU REV BIOCHEM., vol. 67, 1998, pages 99 - 134, XP008157631
DATABASE GENBANK NCBI; 6 December 2009 (2009-12-06), XP008157635, Database accession no. NM_003749
WANG ET AL.: "Colorimetric detection of oligonucleotides using a polydiacetylene vesicle sensor.", ANAL BIOANAL CHEM., vol. 382, no. 7, August 2005 (2005-08-01), pages 1708 - 1710, XP008157624
See also references of EP 2519632A4
Attorney, Agent or Firm:
BROWDER, Monte R. (LLC4400 Biscayne Boulevar, Miami FL, US)
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