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Title:
TREATMENT OF INTERFERON REGULATORY FACTOR 8 (IRF8) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IRF8
Document Type and Number:
WIPO Patent Application WO/2011/082409
Kind Code:
A3
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Interferon Regulatory Factor 8 (IRF8), in particular, by targeting natural antisense polynucleotides of Interferon Regulatory Factor 8 (IRF8). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IRF8.

Inventors:
COLLARD JOSEPH (US)
KHORKOVA SHERMAN OLGA (US)
Application Number:
PCT/US2011/020069
Publication Date:
November 17, 2011
Filing Date:
January 04, 2011
Export Citation:
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Assignee:
OPKO CURNA LLC (US)
COLLARD JOSEPH (US)
KHORKOVA SHERMAN OLGA (US)
International Classes:
C12N15/113; A61K31/7088; A61K48/00
Foreign References:
US20070248590A12007-10-25
US20090155180A12009-06-18
US20090068222A12009-03-12
Other References:
IRINA L. TOURKOVA ET AL.: "Interferon regulatory factor 8 mediates tumor- induced inhibition of antigen processing and presentation by dendritic cells.", CANCER IMMUNOL IMMUNOTHER., vol. 58, no. 4, 2009, pages 567 - 574, XP008157638
DATABASE GENBANK 6 December 2009 (2009-12-06), "Homo sapiens interferon regulatory factor 8 (IRF8), mRNA", XP008157630, Database accession no. NM_002163
HONGSHENG WANG ET AL.: "IRF8 regulates B-cell lineage specification, commitment, and differentiation.", BLOOD, vol. 112, no. 10, 2008, pages 4028 - 4038, XP008157639
See also references of EP 2521784A4
Attorney, Agent or Firm:
BROWDER, Monte, R. (LLC4400 Biscayne Boulevar, Miami FL, US)
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