Title:
TREATMENT METHODS FOR EYE DISORDERS
Document Type and Number:
WIPO Patent Application WO/2021/050744
Kind Code:
A3
Abstract:
A method of inhibiting neutrophil activation in retinal pigment epithelial (RPE) cells comprising administering an inhibitor of interferon (IFN) λ to a subject in need thereof, as well as a method of restoring lysosomal function of RPE cells comprising administering a polypeptide comprising βA1-crystallin or a nucleic acid encoding the polypeptide to a subject in need thereof, are provided. A method of rejuvenating Vacuolar-type H+-ATPase (V-ATPase) activity in RPE cells by modulating assembly and disassembly of the V-ATPase in a subject in need thereof also is provided. Additionally, a method of treating diabetic retinopathy in a subject comprising administering a polypeptide comprising βA1-crystallin or a nucleic acid encoding the polypeptide to the subject is provided.
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Inventors:
SINHA DEBASISH (US)
BYRNE LEAH (US)
STEPICHEVA NADEZDA ANATOLYEVNA (US)
GHOSH SAYAN (US)
HOSE STACEY (US)
BYRNE LEAH (US)
STEPICHEVA NADEZDA ANATOLYEVNA (US)
GHOSH SAYAN (US)
HOSE STACEY (US)
Application Number:
PCT/US2020/050224
Publication Date:
April 22, 2021
Filing Date:
September 10, 2020
Export Citation:
Assignee:
UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US)
International Classes:
A61K9/00; A61K39/00; A61P27/02
Domestic Patent References:
| WO2013104610A1 | 2013-07-18 | |||
| WO2020078865A1 | 2020-04-23 |
Foreign References:
| US20180320180A1 | 2018-11-08 |
Other References:
GHOSH SAYAN, PADMANABHAN ARCHANA, VAIDYA TANUJA, WATSON ALAN M., BHUTTO IMRAN A., HOSE STACEY, SHANG PENG, STEPICHEVA NADEZDA, YAZ: "Neutrophils homing into the retina trigger pathology in early age-related 1 macular degeneration", COMMUNICATION BIOLOGY, vol. 2, no. 1, December 2019 (2019-12-01), XP055659301
GHOSH, S ET AL.: "Activating the AKT2/NFkB/LCN-2 axis elicits an inflammatory response in age-related macular degeneration: Lipocalin-2 as an indicator of early AMD", JOURNAL OF PATHOLOGY, vol. 241, no. 5, 20 February 2017 (2017-02-20), pages 583 - 588, XP055659276, DOI: 10.1002/path.4870
SWIDER ADAM, SIEGEL RACHAEL, ESKDALE JOYCE, GALLAGHER GRANT: "Regulation of interferon lambda-1 (IFNL1/IFN-lambda-1/ IL -29) expression in human colon epithelial cells", CYTOKINE, vol. 65, no. 1, 1 January 2014 (2014-01-01), CN, pages 17 - 23, XP055911901, DOI: 10.1016/j.cyto.2013.09.020
ZENARO, E ET AL.: "Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin", NATURE MEDICINE, vol. 21, no. 8, August 2015 (2015-08-01), pages 880 - 886, XP055389839, DOI: 10.1038/nm.3913
GHOSH, S ET AL.: "Activating the AKT2/NFkB/LCN-2 axis elicits an inflammatory response in age-related macular degeneration: Lipocalin-2 as an indicator of early AMD", JOURNAL OF PATHOLOGY, vol. 241, no. 5, 20 February 2017 (2017-02-20), pages 583 - 588, XP055659276, DOI: 10.1002/path.4870
SWIDER ADAM, SIEGEL RACHAEL, ESKDALE JOYCE, GALLAGHER GRANT: "Regulation of interferon lambda-1 (IFNL1/IFN-lambda-1/ IL -29) expression in human colon epithelial cells", CYTOKINE, vol. 65, no. 1, 1 January 2014 (2014-01-01), CN, pages 17 - 23, XP055911901, DOI: 10.1016/j.cyto.2013.09.020
ZENARO, E ET AL.: "Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin", NATURE MEDICINE, vol. 21, no. 8, August 2015 (2015-08-01), pages 880 - 886, XP055389839, DOI: 10.1038/nm.3913
Attorney, Agent or Firm:
MEJDRICH, Rachel J. et al. (US)
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