Title:
TREATMENT OF URINARY TRACT INFECTIONS WITH ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2010/132777
Kind Code:
A3
Abstract:
A method for treating a urinary tract infection in a mammal in need thereof is disclosed, the method comprising administering to the mammal an effective amount of an antibacterial aminoglycoside compound.
Inventors:
BRUSS JON B (US)
MILLER GEORGE H (US)
AGGEN JAMES BRADLEY (US)
ARMSTRONG ELIANA SAXON (US)
MILLER GEORGE H (US)
AGGEN JAMES BRADLEY (US)
ARMSTRONG ELIANA SAXON (US)
Application Number:
PCT/US2010/034909
Publication Date:
January 20, 2011
Filing Date:
May 14, 2010
Export Citation:
Assignee:
ACHAOGEN INC (US)
BRUSS JON B (US)
MILLER GEORGE H (US)
AGGEN JAMES BRADLEY (US)
ARMSTRONG ELIANA SAXON (US)
BRUSS JON B (US)
MILLER GEORGE H (US)
AGGEN JAMES BRADLEY (US)
ARMSTRONG ELIANA SAXON (US)
International Classes:
A61K31/7028; A61P31/04; C07H15/222
Domestic Patent References:
| WO2009067692A1 | 2009-05-28 |
Foreign References:
| US4214074A | 1980-07-22 | |||
| US4195171A | 1980-03-25 | |||
| DE3100739A1 | 1982-08-26 | |||
| US4234572A | 1980-11-18 | |||
| US4248865A | 1981-02-03 |
Other References:
MADSEN P O ET AL: "Treatment of complicated urinary tract infections - Comparative study of sisomicin and gentamicin", UROLOGY, BELLE MEAD, NJ, US LNKD- DOI:10.1016/0090-4295(77)90309-0, vol. 9, no. 6, 1 June 1977 (1977-06-01), pages 635 - 638, XP023283139, ISSN: 0090-4295, [retrieved on 19770601]
HARRISON ET AL: "Treatment of complicated urinary tract infections with amikacin Comparison of low and high dosage", UROLOGY, BELLE MEAD, NJ, US LNKD- DOI:10.1016/0090-4295(77)90006-1, vol. 10, no. 2, 1 August 1977 (1977-08-01), pages 110 - 113, XP023267383, ISSN: 0090-4295, [retrieved on 19770801]
CUNHA ET AL: "Aminoglycosides in urology", UROLOGY, BELLE MEAD, NJ, US, vol. 36, no. 1, 1 July 1990 (1990-07-01), pages 1 - 14, XP026442620, ISSN: 0090-4295, [retrieved on 19900701]
ALHAMBRA A ET AL: "In vitro susceptibility of recent antibiotic-resistant urinary pathogens to ertapenem and 12 other antibiotics", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 200406 GB LNKD- DOI:10.1093/JAC/DKH218, vol. 53, no. 6, June 2004 (2004-06-01), pages 1090 - 1094, XP002592754, ISSN: 0305-7453
MARRIE T J ET AL: "Clinical and laboratory study of tobramycin in the treatment of infections due to gram-negative organisms.", CANADIAN MEDICAL ASSOCIATION JOURNAL 23 JUL 1977 LNKD- PUBMED:406032, vol. 117, no. 2, 23 July 1977 (1977-07-23), pages 138 - 143, XP002592755, ISSN: 0008-4409
MAIGAARD S ET AL: "COMPARISON OF NETILMICIN AND AMIKACIN IN TREATMENT OF COMPLICATED URINARY TRACT INFECTIONS", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 14, no. 4, 1978, pages 544 - 548, XP002592756, ISSN: 0066-4804
KISHI H ET AL: "[Comparative study on intravenous drip infusion of dibekacin once daily and twice daily in treatment of complicated urinary tract infections]", HINYOKIKA KIYO. ACTA UROLOGICA JAPONICA JAN 1984 LNKD- PUBMED:6375317, vol. 30, no. 1, January 1984 (1984-01-01), pages 103 - 120, XP009136538, ISSN: 0018-1994
YAMANE T ET AL: "Antimicrobial susceptibilities of organisms isolated from patients with complicated urinary tract infections in 2004 and 2005", JAPANESE JOURNAL OF CHEMOTHERAPY 200711 JP, vol. 55, no. 6, November 2007 (2007-11-01), pages 473 - 478, XP009136540, ISSN: 1340-7007
ETRA W ET AL: "Sisomicin in urinary tract infection tolerance and wfficacy study", UROLOGY, BELLE MEAD, NJ, US, vol. 7, no. 2, 1 February 1976 (1976-02-01), pages 160 - 164, XP023270046, ISSN: 0090-4295, [retrieved on 19760201], DOI: DOI:10.1016/0090-4295(76)90303-4
THEURETZBACHER ET AL: "Future antibiotics scenarios: is the tide starting to turn?", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 34, no. 1, 1 April 2009 (2009-04-01), pages 15 - 20, XP026127708, ISSN: 0924-8579, [retrieved on 20090401], DOI: DOI:10.1016/J.IJANTIMICAG.2009.02.005
KOTRETSOU S ET AL: "Synthesis and Antimicrobial and Toxicological Studies of Amino Acid and Peptide Derivatives of Kanamycin A and Netilmicin", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 38, no. 23, 1 November 1995 (1995-11-01), pages 4710 - 4719, XP002588138, ISSN: 0022-2623, DOI: DOI:10.1021/JM00023A011
MALLAMS A K ET AL: "SEMI SYNTHETIC AMINO GLYCOSIDE ANTI BACTERIALS 10. SYNTHESIS OF NOVEL 1-N AMINOALKOXYCARBONYL AND 1-N AMINOALKYLCARBOXAMIDO DERIVATIVES OF SISOMICIN GENTAMICIN B GENTAMICIN C-1A AND KANAMYCIN A", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY, LETCHWORTH; GB, no. 8, 1 January 1981 (1981-01-01), pages 2186 - 2208, XP009138913, ISSN: 0300-922X
RANE DINANATH F ET AL: "Synthesis and in vitro microbiological properties of the 1-N-(3-amino-2-hydroxypropionyl) derivatives of sisomicin and 5-episisomicin", CURRENT CHEMOTHERAPY AND INFECTIOUS DISEASE: PROCEEDINGS OF THE 11TH INTERNATIONAL CONGRESS OF CHEMOTHERAPY AND THE 19TH INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, BOSTON, MASSACHUSETTS, 1-5 OCTOBER 1979,, vol. 1, 1 January 1980 (1980-01-01), pages 408 - 410, XP009138901, ISBN: 978-0-914826-22-4
WRIGHT J J ET AL: "Selective N-acylation of gentamicin antibiotics - synthesis of 1-N-acyl derivatives", JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION, TOKYO, JP, vol. 29, no. 7, 1 January 1976 (1976-01-01), pages 714 - 719, XP009138914, ISSN: 0021-8820
LIN G ET AL: "Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 54, no. 5, 1 May 2010 (2010-05-01), pages 2258 - 2261, XP002595534, ISSN: 0066-4804, [retrieved on 20100209], DOI: DOI:10.1128/AAC.01350-09
ENDIMIANI ANDREA ET AL: "ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 53, no. 10, 1 October 2009 (2009-10-01), pages 4504 - 4507, XP002593065, ISSN: 0066-4804, [retrieved on 20090921], DOI: DOI:10.1128/AAC.00556-09
HARRISON ET AL: "Treatment of complicated urinary tract infections with amikacin Comparison of low and high dosage", UROLOGY, BELLE MEAD, NJ, US LNKD- DOI:10.1016/0090-4295(77)90006-1, vol. 10, no. 2, 1 August 1977 (1977-08-01), pages 110 - 113, XP023267383, ISSN: 0090-4295, [retrieved on 19770801]
CUNHA ET AL: "Aminoglycosides in urology", UROLOGY, BELLE MEAD, NJ, US, vol. 36, no. 1, 1 July 1990 (1990-07-01), pages 1 - 14, XP026442620, ISSN: 0090-4295, [retrieved on 19900701]
ALHAMBRA A ET AL: "In vitro susceptibility of recent antibiotic-resistant urinary pathogens to ertapenem and 12 other antibiotics", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 200406 GB LNKD- DOI:10.1093/JAC/DKH218, vol. 53, no. 6, June 2004 (2004-06-01), pages 1090 - 1094, XP002592754, ISSN: 0305-7453
MARRIE T J ET AL: "Clinical and laboratory study of tobramycin in the treatment of infections due to gram-negative organisms.", CANADIAN MEDICAL ASSOCIATION JOURNAL 23 JUL 1977 LNKD- PUBMED:406032, vol. 117, no. 2, 23 July 1977 (1977-07-23), pages 138 - 143, XP002592755, ISSN: 0008-4409
MAIGAARD S ET AL: "COMPARISON OF NETILMICIN AND AMIKACIN IN TREATMENT OF COMPLICATED URINARY TRACT INFECTIONS", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 14, no. 4, 1978, pages 544 - 548, XP002592756, ISSN: 0066-4804
KISHI H ET AL: "[Comparative study on intravenous drip infusion of dibekacin once daily and twice daily in treatment of complicated urinary tract infections]", HINYOKIKA KIYO. ACTA UROLOGICA JAPONICA JAN 1984 LNKD- PUBMED:6375317, vol. 30, no. 1, January 1984 (1984-01-01), pages 103 - 120, XP009136538, ISSN: 0018-1994
YAMANE T ET AL: "Antimicrobial susceptibilities of organisms isolated from patients with complicated urinary tract infections in 2004 and 2005", JAPANESE JOURNAL OF CHEMOTHERAPY 200711 JP, vol. 55, no. 6, November 2007 (2007-11-01), pages 473 - 478, XP009136540, ISSN: 1340-7007
ETRA W ET AL: "Sisomicin in urinary tract infection tolerance and wfficacy study", UROLOGY, BELLE MEAD, NJ, US, vol. 7, no. 2, 1 February 1976 (1976-02-01), pages 160 - 164, XP023270046, ISSN: 0090-4295, [retrieved on 19760201], DOI: DOI:10.1016/0090-4295(76)90303-4
THEURETZBACHER ET AL: "Future antibiotics scenarios: is the tide starting to turn?", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 34, no. 1, 1 April 2009 (2009-04-01), pages 15 - 20, XP026127708, ISSN: 0924-8579, [retrieved on 20090401], DOI: DOI:10.1016/J.IJANTIMICAG.2009.02.005
KOTRETSOU S ET AL: "Synthesis and Antimicrobial and Toxicological Studies of Amino Acid and Peptide Derivatives of Kanamycin A and Netilmicin", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 38, no. 23, 1 November 1995 (1995-11-01), pages 4710 - 4719, XP002588138, ISSN: 0022-2623, DOI: DOI:10.1021/JM00023A011
MALLAMS A K ET AL: "SEMI SYNTHETIC AMINO GLYCOSIDE ANTI BACTERIALS 10. SYNTHESIS OF NOVEL 1-N AMINOALKOXYCARBONYL AND 1-N AMINOALKYLCARBOXAMIDO DERIVATIVES OF SISOMICIN GENTAMICIN B GENTAMICIN C-1A AND KANAMYCIN A", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY, LETCHWORTH; GB, no. 8, 1 January 1981 (1981-01-01), pages 2186 - 2208, XP009138913, ISSN: 0300-922X
RANE DINANATH F ET AL: "Synthesis and in vitro microbiological properties of the 1-N-(3-amino-2-hydroxypropionyl) derivatives of sisomicin and 5-episisomicin", CURRENT CHEMOTHERAPY AND INFECTIOUS DISEASE: PROCEEDINGS OF THE 11TH INTERNATIONAL CONGRESS OF CHEMOTHERAPY AND THE 19TH INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, BOSTON, MASSACHUSETTS, 1-5 OCTOBER 1979,, vol. 1, 1 January 1980 (1980-01-01), pages 408 - 410, XP009138901, ISBN: 978-0-914826-22-4
WRIGHT J J ET AL: "Selective N-acylation of gentamicin antibiotics - synthesis of 1-N-acyl derivatives", JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION, TOKYO, JP, vol. 29, no. 7, 1 January 1976 (1976-01-01), pages 714 - 719, XP009138914, ISSN: 0021-8820
LIN G ET AL: "Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 54, no. 5, 1 May 2010 (2010-05-01), pages 2258 - 2261, XP002595534, ISSN: 0066-4804, [retrieved on 20100209], DOI: DOI:10.1128/AAC.01350-09
ENDIMIANI ANDREA ET AL: "ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 53, no. 10, 1 October 2009 (2009-10-01), pages 4504 - 4507, XP002593065, ISSN: 0066-4804, [retrieved on 20090921], DOI: DOI:10.1128/AAC.00556-09
Attorney, Agent or Firm:
WAGNER, Emily, W. et al. (Suite 5400701 Fifth Avenu, Seattle Washington, US)
Download PDF: