TRIAZANONANE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR ENHANCED FLUORINE-18 LABELING

Title:

TRIAZANONANE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR ENHANCED FLUORINE-18 LABELING

Document Type and Number:

WIPO Patent Application WO/2012/105814

Kind Code:

A3

Abstract:

The present invention relates to a triazanonane derivative indicated by the chemical formula 1 below, or a pharmaceutically acceptable salt thereof, and a method for preparing same, and the triazanonane derivative according to the present invention forms a complex with a metal-fluoride and displays an effect of increasing the labeling efficiency up to 78-90% when labeling F-18, thus enabling use in various radioactive medicine labeling. [Chemical formula 1] (In the chemical formula 1, R1, R2, A. E. X, n and m are as defined in the present description.

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Inventors:

JEONG JAE MIN (KR)
SHETTY DINESH (KR)
LEE DONG SOO (KR)
CHUNG JUNE-KEY (KR)
LEE MYUNG CHUL (KR)

Application Number:

PCT/KR2012/000790

Publication Date:

November 01, 2012

Filing Date:

February 01, 2012

Export Citation:

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Assignee:

SNU R&DB FOUNDATION (KR)
JEONG JAE MIN (KR)
SHETTY DINESH (KR)
LEE DONG SOO (KR)
CHUNG JUNE-KEY (KR)
LEE MYUNG CHUL (KR)

International Classes:

C07D255/02

Domestic Patent References:

WO2009079024A1

2009-06-25

Foreign References:

US20050120494A1	2005-06-09
US20090246130A1	2009-10-01

Other References:

DINESH SHETTY ET AL.: "Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and 18F-labling study", CHEMICAL COMMUNICATIONS, vol. 47, no. 34, 14 September 2011 (2011-09-14), pages 9732 - 9734
SHUANG LIU: "Radiolabeled Cyclic RGD Peptides as Integrin uvp3-Targeted Radiotracers:MaximizingBindingAffmityviaBivalency", BIOCONJUGATE CHEMISTRY, vol. 20, no. 12, 2009, pages 2199 - 2213

Attorney, Agent or Firm:

LEE, Won Hee (Yoksam-dongKangnam-ku, Seoul 135-080, KR)

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