Title:
TRIAZOLO PYRAZINE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/121825
Kind Code:
A1
Abstract:
A triazolo pyrazine compound, wherein the triazolo pyrazine compound is a compound as represented by formula (I) as follows, or a stereoisomer, a geometrical isomer, a tautomer, a hydrate, a solvate, and a pharmaceutically acceptable salt or a prodrug thereof, wherein W is selected from a substituted or unsubstituted aryl or heteroaryl, X is C or N, and R is H or any substituent group. When the triazolo pyrazine compound provided by the invention is used as a Tyk2 specific inhibitor, a more targeted drug can be provided for autoimmune inflammatory diseases driven by an IL-23/Th17 axis, and the compound can be used for treating rheumatoid arthritis, psoriasis, ankylosing spondylitis, sicca syndrome, lupus erythematosus, inflammatory bowel disease, Behcet's disease, severe COVID-19 pneumonia and other diseases more safely and effectively.
Inventors:
FANG WENKUI (CN)
LI GUANQUN (CN)
CAI YUTING (CN)
PAN XIANG (CN)
ZHU WENHAO (CN)
WANG YANG (CN)
WANG ZENGQUAN (CN)
LI GUANQUN (CN)
CAI YUTING (CN)
PAN XIANG (CN)
ZHU WENHAO (CN)
WANG YANG (CN)
WANG ZENGQUAN (CN)
Application Number:
PCT/CN2021/135633
Publication Date:
June 16, 2022
Filing Date:
December 06, 2021
Export Citation:
Assignee:
TECHNODERMA MEDICINES INC (CN)
International Classes:
C07D487/04; A61P1/02; A61P29/00; C07D519/00
Domestic Patent References:
| WO2020207476A1 | 2020-10-15 | |||
| WO2017144995A1 | 2017-08-31 | |||
| WO2019034973A1 | 2019-02-21 |
Foreign References:
| CN112592345A | 2021-04-02 |
Other References:
GERSTENBERGER BRIAN S., AMBLER CATHERINE, ARNOLD ERIC P., BANKER MARY-ELLEN, BROWN MATTHEW F., CLARK JAMES D., DERMENCI ALPAY, DOW: "Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, no. 22, 25 November 2020 (2020-11-25), US , pages 13561 - 13577, XP055883558, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c00948
Attorney, Agent or Firm:
ZHONG LUN LAW FIRM (CN)
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