Title:
TRICYCLIC CARBOXAMIDES
Document Type and Number:
WIPO Patent Application WO2000008020
Kind Code:
A3
Abstract:
Compounds of formula (I) or salt thereof or solvate thereof, in which: m is 1 or 2; n is 1 or 2; X is CH or N; Y is selected from hydrogen, halogen, cyano, CF3, alkyl or alkoxy; R<1>, which may be at any position within the saturated ring system, is hydrogen or up to two substituents which may be the same or different and each of which is selected from fluoro and C1-6 alkyl; R<2> is hydrogen or up to four substituents selected from halogen, NO2, CN, N3, CF3O-, CF3S-, CF3CO-, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6-alkylCO-, C3-6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-, (C1-4alkyl)NHSO2-, (C1-4alkyl)2NCO-, oxazolyl, (C1-4alkyl)NHCO-, CONH2; or R<4>CONH- or -NR<4>R<5>, wherein R<4> is hydrogen or C1-4 alkyl; and R<5> is hydrogen, C1-4alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R<2> groups are linked together form a carbocyclic or heterocyclic ring that is saturated or unsaturated and unsubstituted or substituted by -OH or =O are indicated to be useful in the treatment and pophylaxis of epilepsy, migraine, and other disorders.
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Inventors:
COULTON STEVEN (GB)
NOVELLI RICCARDO (GB)
PORTER RODERICK ALAN (GB)
THOMPSON MERVYN (GB)
WARD ROBERT WILLIAM (GB)
NOVELLI RICCARDO (GB)
PORTER RODERICK ALAN (GB)
THOMPSON MERVYN (GB)
WARD ROBERT WILLIAM (GB)
Application Number:
PCT/EP1999/005584
Publication Date:
July 13, 2000
Filing Date:
August 03, 1999
Export Citation:
Assignee:
SMITHKLINE BEECHAM PLC (GB)
COULTON STEVEN (GB)
NOVELLI RICCARDO (GB)
PORTER RODERICK ALAN (GB)
THOMPSON MERVYN (GB)
WARD ROBERT WILLIAM (GB)
COULTON STEVEN (GB)
NOVELLI RICCARDO (GB)
PORTER RODERICK ALAN (GB)
THOMPSON MERVYN (GB)
WARD ROBERT WILLIAM (GB)
International Classes:
A61K31/4375; A61K31/4745; A61K31/55; A61P9/10; A61P25/00; A61P25/02; A61P25/08; A61P25/10; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; C07D455/03; C07D471/04; C07D471/14; C07D487/04; (IPC1-7): C07D471/04; A61K31/437; A61K31/55; C07D455/04; C07D487/04; C07D471/14; A61P25/00
Foreign References:
EP0067565A1 | 1982-12-22 |
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