Title:
TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143489
Kind Code:
A1
Abstract:
A tricyclic compound having the structure represented by general formula (I), a pharmaceutical composition thereof, a preparation method therefor and the use thereof in the prevention and treatment of a variety of diseases caused by toxic aldehydes.
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Inventors:
YIN HUIJUN (CN)
YAN XU (CN)
LIU GUOBIAO (CN)
SHI JIANXIN (CN)
CHEN SHIZHU (CN)
YAN XU (CN)
LIU GUOBIAO (CN)
SHI JIANXIN (CN)
CHEN SHIZHU (CN)
Application Number:
PCT/CN2021/141502
Publication Date:
July 07, 2022
Filing Date:
December 27, 2021
Export Citation:
Assignee:
THE NAT INSTITUTES OF PHARMACEUTICAL R&D CO LTD (CN)
International Classes:
C07D491/056; A61K31/136; A61K31/423; A61K31/47; A61P9/00; A61P11/00; A61P15/00; A61P25/00; A61P27/02; A61P35/00; A61P37/00; C07D471/04; C07D491/048; C07D493/00; C07D498/00
Domestic Patent References:
| WO2017132538A1 | 2017-08-03 | |||
| WO2018039192A1 | 2018-03-01 |
Foreign References:
| CN108135867A | 2018-06-08 | |||
| CN101321742A | 2008-12-10 | |||
| CN105120866A | 2015-12-02 | |||
| CN109640983A | 2019-04-16 |
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FERON ET AL., MUTATION RESEARCH/GENETIC TOXICOLOGY, vol. 259, no. 3-4, 1991, pages 363 - 385
MARNETT ET AL., HEALTH EFFECTS INSTITUTE. NATIONAL ACADEMY, 1988
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NELSON ET AL., CURRENT OPINION IN PHARMACOLOGY, vol. 33, 2017, pages 56 - 63
BARRERA ET AL., ANTIOXIDANTS & REDOX SIGNALING, vol. 22, no. 18, 2015, pages 1681 - 1702
MOGHE ET AL., TOXICOLOGICAL SCIENCES, vol. 143, no. 2, 2015, pages 242 - 255
SINGH ET AL., THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, vol. 18, no. 1, 2014, pages 1 - 14
THOMALLEY ET AL., NUCLEIC ACIDS RESEARCH, vol. 38, no. 16, 2010, pages 5432 - 5442
YAOBROWNLEE, DIABETES, vol. 59, no. 1, 2010, pages 249 - 255
AHMED ET AL., DIABETOLOGIA, vol. 48, no. 8, 2005, pages 1590 - 1603
BRUNO ET AL., JOURNAL OF PROTEOME RESEARCH, vol. 52, no. 4, 2009, pages 2070 - 2078
CHAN ET AL., JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 100, no. 4, 2007, pages 1056 - 1069
DOBLER ET AL., DIABETES, vol. 55, no. 7, 2006, pages 1961 - 1969
SHANGARI ET AL., BIOCHEMICAL PHARMACOLOGY, vol. 71, no. 11, 2006, pages 1610 - 1618
FEBBRAIO ET AL.: "Cellular Lipid Binding Proteins.", 2002, SPRINGER, pages: 193 - 197
CHARLTON ET AL., HEPATOLOGY, vol. 49, no. 4, 2009, pages 1375 - 1384
T. W. GREENEG. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY
O'BRIEN ET AL., CRITICAL REVIEWS IN TOXICOLOGY, vol. 35, no. 7, 2005, pages 609 - 662
FERON ET AL., MUTATION RESEARCH/GENETIC TOXICOLOGY, vol. 259, no. 3-4, 1991, pages 363 - 385
MARNETT ET AL., HEALTH EFFECTS INSTITUTE. NATIONAL ACADEMY, 1988
ESTERBAUER ET AL., FREE RADICAL BIOLOGY AND MEDICINE, vol. 11, no. 1, 1991, pages 81 - 128
VOULGARIDOU ET AL., MUTATION RESEARCH/FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, vol. 711, no. 1-2, 2011, pages 13 - 27
NELSON ET AL., CURRENT OPINION IN PHARMACOLOGY, vol. 33, 2017, pages 56 - 63
BARRERA ET AL., ANTIOXIDANTS & REDOX SIGNALING, vol. 22, no. 18, 2015, pages 1681 - 1702
MOGHE ET AL., TOXICOLOGICAL SCIENCES, vol. 143, no. 2, 2015, pages 242 - 255
SINGH ET AL., THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, vol. 18, no. 1, 2014, pages 1 - 14
THOMALLEY ET AL., NUCLEIC ACIDS RESEARCH, vol. 38, no. 16, 2010, pages 5432 - 5442
YAOBROWNLEE, DIABETES, vol. 59, no. 1, 2010, pages 249 - 255
AHMED ET AL., DIABETOLOGIA, vol. 48, no. 8, 2005, pages 1590 - 1603
BRUNO ET AL., JOURNAL OF PROTEOME RESEARCH, vol. 52, no. 4, 2009, pages 2070 - 2078
CHAN ET AL., JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 100, no. 4, 2007, pages 1056 - 1069
DOBLER ET AL., DIABETES, vol. 55, no. 7, 2006, pages 1961 - 1969
SHANGARI ET AL., BIOCHEMICAL PHARMACOLOGY, vol. 71, no. 11, 2006, pages 1610 - 1618
FEBBRAIO ET AL.: "Cellular Lipid Binding Proteins.", 2002, SPRINGER, pages: 193 - 197
CHARLTON ET AL., HEPATOLOGY, vol. 49, no. 4, 2009, pages 1375 - 1384
T. W. GREENEG. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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