Title:
TRICYCLIC COMPOUNDS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/161347
Kind Code:
A1
Abstract:
A series of tricyclic compounds and the use thereof. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.
Inventors:
HUANG JINGJIE (CN)
YU TAO (CN)
TAN YE (CN)
WU CHENGDE (CN)
CHEN SHUHUI (CN)
YU TAO (CN)
TAN YE (CN)
WU CHENGDE (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2022/073734
Publication Date:
August 04, 2022
Filing Date:
January 25, 2022
Export Citation:
Assignee:
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D498/04; A61K31/4162; A61K31/553; A61K31/554; A61P35/00; C07D498/14
Domestic Patent References:
| WO2019228341A1 | 2019-12-05 | |||
| WO2020020385A1 | 2020-01-30 | |||
| WO2021088845A1 | 2021-05-14 | |||
| WO2021104146A1 | 2021-06-03 | |||
| WO2021113219A1 | 2021-06-10 |
Foreign References:
| CN107873032A | 2018-04-03 | |||
| CN202110134377A | 2021-01-29 | |||
| CN202210020761A | 2022-01-07 |
Other References:
LU LIANG, SHA SHAO, WANG KAI, ZHANG YUAN-HENG, LIU YAN-DONG, JU GUO-DONG, WANG BAOZHONG, ZHU HAI-LIANG: "Discovery of Chromeno[4,3-c]pyrazol-4(2H)-one Containing Carbonyl or Oxime Derivatives as Potential, Selective Inhibitors PI3Kα", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 64, no. 64, 1 September 2016 (2016-09-01), JP , pages 1576 - 1581, XP055955314, ISSN: 0009-2363, DOI: 10.1248/cpb.c16-00388
LV XIAN-HAI; LI QING-SHAN; REN ZI-LI; CHU MING-JIE; SUN JIAN; ZHANG XIN; XING MAN; ZHU HAI-LIANG; CAO HAI-QUN: "(E)-1,3-diphenyl-1H-pyrazole derivatives containing O-benzyl oxime moiety as potential immunosuppressive agents: Design, synthesis, molecular docking and biological evaluation", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 108, 15 December 2015 (2015-12-15), AMSTERDAM, NL , pages 586 - 593, XP029383528, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2015.12.020
RAJESH KUMAR M., ALAGUMUTHU MANIKANDAN, VIOLET DHAYABARAN V.: "N-substituted hydroxynaphthalene imino-oxindole derivatives as new class of PI3-kinase inhibitor and breast cancer drug: Molecular validation and structure-activity relationship studies", CHEMICAL BIOLOGY & DRUG DESIGN, BLACKWELL MUNKSGAARD, vol. 91, no. 1, 1 January 2018 (2018-01-01), pages 277 - 284, XP055955322, ISSN: 1747-0277, DOI: 10.1111/cbdd.13079
LV XIAN-HAI; LI QING-SHAN; REN ZI-LI; CHU MING-JIE; SUN JIAN; ZHANG XIN; XING MAN; ZHU HAI-LIANG; CAO HAI-QUN: "(E)-1,3-diphenyl-1H-pyrazole derivatives containing O-benzyl oxime moiety as potential immunosuppressive agents: Design, synthesis, molecular docking and biological evaluation", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 108, 15 December 2015 (2015-12-15), AMSTERDAM, NL , pages 586 - 593, XP029383528, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2015.12.020
RAJESH KUMAR M., ALAGUMUTHU MANIKANDAN, VIOLET DHAYABARAN V.: "N-substituted hydroxynaphthalene imino-oxindole derivatives as new class of PI3-kinase inhibitor and breast cancer drug: Molecular validation and structure-activity relationship studies", CHEMICAL BIOLOGY & DRUG DESIGN, BLACKWELL MUNKSGAARD, vol. 91, no. 1, 1 January 2018 (2018-01-01), pages 277 - 284, XP055955322, ISSN: 1747-0277, DOI: 10.1111/cbdd.13079
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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