Title:
TRIPEPTIDE PROPYLENE OXIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/244224
Kind Code:
A1
Abstract:
Disclosed are a tripeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor and an application thereof. The structure of the tripeptide ethylene oxide derivative is as represented by formula I. Compared with the prior art, the present invention provides tripeptide epoxy ketone compounds having a novel structure and having the function of inhibiting a proteasome. As 20S proteasome inhibitors, the compounds can block tumor cell proliferation and induce apoptosis in tumor cell, and therefore can be used for the treatment and prevention of a plurality of diseases of human and animals such as malignant tumor. The effect is significantly better.
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Inventors:
ZHU YONGQIANG (CN)
LEI MENG (CN)
ZHANG HAOYANG (CN)
LEI MENG (CN)
ZHANG HAOYANG (CN)
Application Number:
PCT/CN2020/070197
Publication Date:
December 10, 2020
Filing Date:
January 03, 2020
Export Citation:
Assignee:
UNIV NANJING (CN)
International Classes:
A61K38/06; C07K5/087; A61K38/07; A61P35/00; C07K1/06; C07K5/097; C07K5/117
Domestic Patent References:
| WO2008140782A2 | 2008-11-20 |
Foreign References:
| CN110092813A | 2019-08-06 | |||
| CN102875642A | 2013-01-16 |
Other References:
KOROLEVA, O. N. ET AL.: "Bisbenzimidazole Derivatives as Potent Inhibitors of the Trypsin-like Sites of the Immunoproteasome Core Particle", BIOCHIMIE, no. 108, 13 November 2014 (2014-11-13), XP055765683, DOI: 20200326153907X
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP) (CN)
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